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Type 1 diabetes in adolescent

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https://www.readbyqxmd.com/read/28533125/markers-of-immune-mediated-inflammation-in-the-brains-of-young-adults-and-adolescents-with-type-1-diabetes-and-fatal-diabetic-ketoacidosis-is-there-a-difference
#1
William H Hoffman, Carol M Artlett, Dallas Boodhoo, Mary G F Gilliland, Luis Ortiz, Dries Mulder, David H T Tjan, Alvaro Martin, Alexandru Tatomir, Horea Rus
Due to the limited data on diabetic ketoacidosis and brain edema (DKA/BE) in children/adolescents and the lack of recent data on adults with type 1 diabetes (T1D), we addressed the question of whether neuroinflammation was present in the fatal DKA of adults. We performed immunohistochemistry (IHC) studies on the brains of two young adults with T1D and fatal DKA and compared them with two teenagers with poorly controlled diabetes and fatal DKA. C5b-9, the membrane attack complex (MAC) had significantly greater deposits in the grey and white matter of the teenagers than the young adults (p=0...
May 19, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28514270/recognizing-type-1-diabetes-mellitus-in-children-adolescents
#2
(no author information available yet)
No abstract text is available yet for this article.
June 16, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28509784/pharmacotherapy-options-for-pediatric-diabetes
#3
Maria Loredana Marcovecchio, Francesco Chiarelli
PURPOSE OF REVIEW: Type 1 diabetes (T1D) and type 2 diabetes (T2D) are frequent conditions during childhood and adolescence. The present review offers an update on current available treatment strategies for T1D and T2D approved for use in children and adolescents. RECENT FINDINGS: Insulin remains the main and essential therapeutic strategy in youth with T1D. A second generation of insulin analogues is being evaluated and could help in improving glycemic control...
May 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28505610/predictors-of-loss-to-follow-up-among-children-with-type-2-diabetes
#4
Ashley Shoemaker, Peiyao Cheng, Robin L Gal, Craig Kollman, William V Tamborlane, Georgeanna J Klingensmith, Mark A Clements, Tamara S Hannon, Rubina Heptulla, Joane Less, Jamie Wood
BACKGROUND/AIMS: Youth with type 2 diabetes (T2D) have poor compliance with medical care. This study aimed to determine which demographic and clinical factors differ between youth with T2D who receive care in a pediatric diabetes center versus youth lost to follow-up for >18 months. METHODS: Data were analyzed from 496 subjects in the Pe-diatric Diabetes Consortium registry. Enrollment variables were selected a priori and analyzed with univariable and multivariable logistic regression models...
May 15, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28500868/type-1-diabetes-mellitus-care-and-education-in-china-the-3c-study-of-coverage-cost-and-care-in-beijing-and-shantou
#5
Helen C McGuire, Linong Ji, Katarzyna Kissimova-Skarbek, David Whiting, Florencia Aguirre, Puhong Zhang, Shaoda Lin, Chunxiu Gong, Weigang Zhao, Juming Lu, Xiaohui Guo, Ying Ji, Till Seuring, Tianpei Hong, Lishu Chen, Jianping Weng, Zhiguang Zhou
AIMS: The paucity of data on Type 1 diabetes in China hinders progress in care and policy-making. This study compares Type 1 diabetes care and clinical outcomes in Beijing and Shantou with current clinical guidelines. METHODS: The 3C Study was a cross-sectional study of the clinical practices and outcomes of people with Type 1 diabetes. The study sequentially enrolled 849 participants from hospital records, inpatient wards, and outpatient clinics. Data were collected via face-to-face interviews with patients and health professionals, the Summary of Diabetes Self-Care Activities, medical records, and venous blood samples...
February 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28500504/delay-discounting-and-parental-monitoring-in-adolescents-with-poorly-controlled-type-1-diabetes
#6
Amy Hughes Lansing, Catherine Stanger, Rebecca Crochiere, Ann Carracher, Alan Budney
In a sample of adolescents with poorly controlled type 1 diabetes, this study examined if delay discounting, the extent to which individuals prefer immediate over delayed rewards, was associated with severity of non-adherence and poor glycemic control, and if parental monitoring of diabetes management moderated those associations. Sixty-one adolescents (M age = 15.08 years, SD 1.43) with poorly controlled type 1 diabetes completed a delayed discounting task and an HbA1c blood test. Adherence was assessed via self-monitoring of blood glucose (SMBG) data from adolescents' glucometers...
May 12, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28491304/health-care-to-empower-self-care-in-adolescents-with-type-1-diabetes-mellitus-and-an-immigrant-minority-background
#7
Åse Boman, Margareta Bohlin, Mats Eklöf, Gun Forsander, Christian Munthe, Marianne Törner
BACKGROUND: The pediatric diabetes team aims to support health, quality of life, and normal growth and development among adolescents with type 1 diabetes mellitus. Adolescents with an immigrant background have been found less successful in self-care. Previous research indicated that adolescents who had integrated the disease as a part of their self-image reasoned differently about their self-care to those who had not. OBJECTIVE: The aim of this study was to identify elements in the patient-pediatrician consultations that might influence such integration of the disease among adolescents with type 1 diabetes mellitus...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28489225/models-of-care-for-adolescents-and-young-adults-with-type-1-diabetes-in-transition-shared-medical-appointments-and-telemedicine
#8
Jennifer K Raymond
Transitioning through adolescence and young adulthood is challenging, and even more so for patients living with a chronic disease such as type 1 diabetes. Patients in this age group encounter multiple obstacles to effectively managing their diabetes, experience suboptimal glycemic control, face higher rates of acute complications, and are often lost to medical follow-up. Comprehensive strategies and innovative clinical models are needed to engage this population in diabetes medical care, address barriers to ideal management, and improve outcomes...
May 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28488397/dietary-sodium-intake-relates-to-vascular-health-in-children-with-type-1-diabetes
#9
Jemma Anderson, Jennifer J Couper, Sarah Toome, Christine Mpundu-Kaambwa, Lynne C Giles, Roger Gent, Brian Coppin, Alexia S Peña
BACKGROUND AND OBJECTIVE: Children with type 1 diabetes (T1D) have vascular dysfunction and frequently struggle to adhere to dietary recommendations. Limited data exist for the vascular consequences of poor diet quality in children. We aimed to evaluate the association between dietary components and vascular function in children with T1D. METHODS: Cross-sectional study including 90 children (13.6 [3.5] years, 41 boys) with T1D. They had evaluation of dietary micro and macronutrients (Australian Child and Adolescent Eating Survey), vascular endothelial and smooth muscle function (flow-mediated dilatation and glyceryl trinitrate mediated dilatation [GTN], respectively), clinical and biochemical variables...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28482273/neighborhood-disorder-and-glycemic-control-in-late-adolescents-with-type-1-diabetes
#10
Tara L Queen, Katherine J W Baucom, Ashley C Baker, Daniel Mello, Cynthia A Berg, Deborah J Wiebe
OBJECTIVE: To evaluate the contribution of neighborhood characteristics to treatment adherence and glycemic control in late adolescents with Type 1 diabetes. RESEARCH DESIGN AND METHODS: As part of a larger study, 220 late adolescents with Type 1 diabetes (aged 17.8 ± 0.4 years, 59.6% female, diabetes duration 7.3 ± 3.9 years) were recruited from outpatient pediatric clinics during their senior year of high school. Adolescents completed self-report measures of adherence behaviors and subjective social status, and their HbA1c values were collected during a lab assessment...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28482269/skeletal-growth-and-bone-mineral-acquisition-in-type-1-diabetic-children-abnormalities-of-the-gh-igf-1-axis
#11
REVIEW
Manish Raisingani, Brar Preneet, Brenda Kohn, Shoshana Yakar
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases diagnosed in childhood. Childhood and adolescent years are also the most important period for growth in height and acquisition of skeletal bone mineral density (BMD). The growth hormone (GH)/insulin like growth factor -1 (IGF-1) axis which regulates growth, is affected by T1DM, with studies showing increased GH and decreased IGF-1 levels in children with T1DM. There is conflicting data as to whether adolescents with TIDM are able to achieve their genetically-determined adult height...
April 28, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28480657/urinary-glucose-screening-for-early-detection-of-asymptomatic-type-2-diabetes-in-jeonbuk-province-korean-schoolchildren
#12
Min Sun Kim, Dae Yeol Lee
This study aimed to investigate the prevalence of glucosuria and the characteristics of diabetes in schoolchildren as detected by a school urine glucose screening program implemented from 2010 to 2013 in the Jeonbuk province area of Korea. A total of 110 children without known diabetes were analyzed. They were checked with an oral glucose tolerance test (OGTT) with other laboratory tests and their clinical data were collected. A total of 707,238 schoolchildren from a school population of 1,064,999 were screened for glucosuria...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28476567/dietary-intake-and-risk-of-non-severe-hypoglycemia-in-adolescents-with-type-1-diabetes
#13
Victor W Zhong, Jamie L Crandell, Christina M Shay, Penny Gordon-Larsen, Stephen R Cole, Juhaeri Juhaeri, Anna R Kahkoska, David M Maahs, Michael Seid, Gregory P Forlenza, Elizabeth J Mayer-Davis
AIMS: To determine the association between dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes. METHODS: Type 1 adolescents from a randomized trial wore a blinded continuous glucose monitoring (CGM) system at baseline for one week in free-living conditions. Dietary intake was calculated as the average from two 24-h dietary recalls. Non-severe hypoglycemia was defined as having blood glucose <70mg/dL for ≥10min but not requiring external assistance, categorized as daytime and nocturnal (11PM-7AM)...
April 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28472211/progressive-retinal-vasodilation-in-patients-with-type-1-diabetes-a-longitudinal-study-of-retinal-vascular-geometry
#14
Gerald Liew, Paul Benitez-Aguirre, Maria E Craig, Alicia J Jenkins, Lauren A B Hodgson, Annette Kifley, Paul Mitchell, Tien Y Wong, Kim Donaghue
Purpose: Retinal vessels can be used to noninvasively monitor changes in microvasculature. These changes in retinal vascular geometry (RVG) may predict chronic diabetes complications. We evaluated longitudinal RVG changes in adolescents with type 1 diabetes. Methods: We followed 102 adolescents (baseline: 47.1% male, mean [SD] age 14.4 [1.6] years, diabetes duration 7.2 [3.1] years, HbA1c 8.1% [1.3%] [65 (9.3) mmol/mol]) over three visits, with a mean follow-up of 2...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28459844/a-predictive-model-for-lack-of-partial-clinical-remission-in-new-onset-pediatric-type-1-diabetes
#15
Katherine R Marino, Rachel L Lundberg, Aastha Jasrotia, Louise S Maranda, Michael J Thompson, Bruce A Barton, Laura C Alonso, Benjamin Udoka Nwosu
IMPORTANCE: >50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification of these patients may improve initial glycemic control and reduce long-term complications. AIM: To determine whether routinely obtainable clinical parameters predict non-remission in children and adolescents with new-onset T1D. SUBJECTS AND METHODS: Data on remission were collected for the first 36 months of disease in 204 subjects of ages 2-14 years with new-onset type 1 diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28459617/outpatient-closed-loop-control-with-unannounced-moderate-exercise-in-adolescents-using-zone-model-predictive-control
#16
Lauren M Huyett, Trang T Ly, Gregory P Forlenza, Suzette Reuschel-DiVirgilio, Laurel H Messer, R Paul Wadwa, Ravi Gondhalekar, Francis J Doyle, Jordan E Pinsker, David M Maahs, Bruce A Buckingham, Eyal Dassau
BACKGROUND: The artificial pancreas (AP) has the potential to improve glycemic control in adolescents. This article presents the first evaluation in adolescents of the Zone Model Predictive Control and Health Monitoring System (ZMPC+HMS) AP algorithms, and their first evaluation in a supervised outpatient setting with frequent exercise. MATERIALS AND METHODS: Adolescents with type 1 diabetes underwent 3 days of closed-loop control (CLC) in a hotel setting with the ZMPC+HMS algorithms on the Diabetes Assistant platform...
May 1, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28459159/a-comparison-of-time-delay-in-three-continuous-glucose-monitors-for-adolescents-and-adults
#17
Manasi Sinha, Katherine M McKeon, Savan Parker, Laura G Goergen, Hui Zheng, Firas H El-Khatib, Steven J Russell
BACKGROUND: The physiologic delay in glucose diffusion from the blood to the interstitial fluid and instrumental factors contribute to the delay between changes in plasma glucose (PG) and measurements made by continuous glucose monitors (CGMs). This study compared the duration of this delay for three CGMs. METHODS: A total of 24 healthy adolescent and adult subjects with type 1 diabetes wore three CGM devices simultaneously for 48 hours: Dexcom G4 Platinum, Abbott Navigator, and Medtronic Enlite...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28449285/research-review-childhood-chronic-physical-illness-and-adult-emotional-health-a-systematic-review-and-meta-analysis
#18
REVIEW
Ekin Secinti, Ellen J Thompson, Marcus Richards, Darya Gaysina
BACKGROUND: Childhood chronic physical illness is associated with a greater vulnerability for emotional problems (i.e. depression and anxiety) in childhood. However, little is known about life-long effects of childhood chronic physical illness on mental health. The present study aims to systematically review evidence for associations between eight chronic physical illnesses with childhood onset (arthritis, asthma, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, type 1 diabetes, and epilepsy) and adult emotional problems...
April 27, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28446529/strengths-risk-factors-and-resilient-outcomes-in-adolescents-with-type-1-diabetes-results-from-diabetes-miles-youth-australia
#19
Marisa E Hilliard, Virginia Hagger, Christel Hendrieckx, Barbara J Anderson, Steven Trawley, Michelle M Jack, Frans Pouwer, Timothy Skinner, Jane Speight
OBJECTIVE: Despite the challenges of living with type 1 diabetes, many adolescents achieve "resilient outcomes": high engagement in self-management behaviors such as self-monitoring of blood glucose (SMBG), good quality of life (QOL), and within-target glycemic outcomes (HbA1c). Adaptive diabetes-related behaviors (i.e., "strengths") are associated with resilient outcomes, yet the combination of risks and strengths in relation to resilient outcomes is unclear. The aim of this study was to investigate relations among diabetes strengths and resilient outcomes in the context of psychological and family risk factors...
April 26, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28441163/recognizing-type-1-diabetes-mellitus-in-children-adolescents
#20
Melissa A Glassford
The common chief complaint of abdominal pain, nausea, and vomiting should prompt a broad differential diagnosis list. When a 17-year-old previously healthy male presented to a primary care clinic with these symptoms, it provoked a detailed workup and found a startling diagnosis of type 1 diabetes mellitus (T1DM). This article provides an overview of recognizing T1DM in children and adolescents with a thorough and diagnostic evaluation.
June 16, 2017: Nurse Practitioner
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