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Type 1 diabetes in adolescent

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https://www.readbyqxmd.com/read/28822064/evolution-of-29-anthropometric-nutritional-and-cardiometabolic-parameters-among-morbidly-obese-adolescents-2-years-post-sleeve-gastrectomy
#1
Wahiba Elhag, Walid El Ansari, Sama Abdulrazzaq, Ali Abdullah, Mohamed Elsherif, Israa Elgenaied
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a popular treatment for adolescent morbid obesity. Research on LSG outcomes among adolescents assessed a narrow range of anthropometric, nutritional, or cardiometabolic parameters, leading to an incomplete picture of these changes. We examined a wide variety of anthropometric, nutritional, and cardiometabolic parameters among adolescents before and after LSG. METHODS: We retrospectively reviewed medical charts of all obese adolescents who underwent LSG at Hamad Medical Corporation, Qatar, between January 2011 and June 2015 (N = 102)...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28819992/insulin-delivery-and-nocturnal-glucose-control-in-children-and-adolescents-with-type-1-diabetes
#2
Martin Tauschmann, Roman Hovorka
Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems...
August 18, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28819457/type-1-diabetes-urinary-proteomics-and-protein-network-analysis-support-perturbation-of-lysosomal-function
#3
Harinder Singh, Yanbao Yu, Moo-Jin Suh, Manolito G Torralba, Robert D Stenzel, Andrey Tovchigrechko, Vishal Thovarai, Derek M Harkins, Seesandra V Rajagopala, Whitney Osborne, Fran R Cogen, Paul B Kaplowitz, Karen E Nelson, Ramana Madupu, Rembert Pieper
While insulin replacement therapy restores the health and prevents the onset of diabetic complications (DC) for many decades, some T1D patients have elevated hemoglobin A1c values suggesting poor glycemic control, a risk factor of DC. We surveyed the stool microbiome and urinary proteome of a cohort of 220 adolescents and children, half of which had lived with T1D for an average of 7 years and half of which were healthy siblings. Phylogenetic analysis of the 16S rRNA gene did not reveal significant differences in gut microbial alpha-diversity comparing the two cohorts...
2017: Theranostics
https://www.readbyqxmd.com/read/28818842/what-s-new-in-paediatric-hypertension
#4
REVIEW
Rowena Lalji, Kjell Tullus
Paediatric hypertension predisposes to hypertension and cardiovascular disease in adult life. Despite clear guidelines, there remains a lack of screening. Diagnosis remains challenging given the high rate of false-positive high blood pressure (BP) readings at a single visit; thus, multiple visits are required to confirm the diagnosis. Depending on the normative data sets used, hypertension in overweight and obese children can be underestimated by up to 20%. Specific BP targets are required for subgroups such as adolescents, children with chronic kidney disease (CKD) and type 1 diabetes...
August 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28810470/representations-and-experiences-of-well-being-among-diabetic-adolescents-relational-normative-and-identity-tensions-in-diabetes-self-management
#5
David Fonte, Sébastien Colson, José Côté, Rachel Reynaud, Marie-Claude Lagouanelle-Simeoni, Thémis Apostolidis
We explore representations of well-being in adolescents with Type 1 diabetes in order to better understand their expectations and needs in therapeutic patient education. In total, 28 interviews were performed and then submitted to thematic content analysis and lexicometric analysis. Results show the intervention of psychosocial processes in the relationship that adolescents maintain with well-being and self-management. More specifically, we observed that well-being is impacted by areas of tension between the expectations of adolescents and the therapeutic objectives expressed by health professionals...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28809783/role-of-omentin-vaspin-cardiotrophin-1-tweak-and-nov-ccn3-in-obesity-and-diabetes-development
#6
REVIEW
Xavier Escoté, Saioa Gómez-Zorita, Miguel López-Yoldi, Iñaki Milton-Laskibar, Alfredo Fernández-Quintela, J Alfredo Martínez, María J Moreno-Aliaga, María P Portillo
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28809093/caregiving-for-children-with-type-1-diabetes-and-clinical-outcomes-in-central-india-the-idream-study
#7
Greta Friedemann-Sánchez, Benjamin D Capistrant, James Ron, Lindsey Novak, Caroline Zuijdwijk, Graham D Ogle, Barbara Anderson, Antoinette Moran, Sharad Pendsey
AIMS: Parental care influences outcomes for children's type 1 diabetes (T1D). There is little evidence about the impact of parental caregiving in developing countries, where fixed dose human insulin (conventional) therapy and limited self-monitoring of blood glucose are common. This article investigates whether performance of key T1D management tasks by children or their caregivers impacts hemoglobin A1c (HbA1c). METHODS: We surveyed the caregivers of 179 children with T1D routinely treated in a specialized diabetes clinic in Maharashtra, India to determine who performs key diabetes care tasks: child or parent...
August 15, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28799164/preconception-care-for-diabetic-women-for-improving-maternal-and-infant-health
#8
REVIEW
Joanna Tieu, Philippa Middleton, Caroline A Crowther, Emily Shepherd
BACKGROUND: Infants born to mothers with pre-existing type 1 or type 2 diabetes mellitus are at greater risk of congenital anomalies, perinatal mortality and significant morbidity in the short and long term. Pregnant women with pre-existing diabetes are at greater risk of perinatal morbidity and diabetic complications. The relationship between glycaemic control and health outcomes for both mothers and infants indicates the potential for preconception care for these women to be of benefit...
August 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28795013/management-of-diabetes-mellitus-in-children-and-adolescents-engaging-in-physical-activity
#9
REVIEW
Silpa Nadella, Justin A Indyk, Manmohan K Kamboj
Regular physical activity is an important component in the management of both type 1 and type 2 diabetes mellitus (T1DM and T2DM), as it has the potential to improve glycemic control, delay cardiovascular complications, and increase overall well-being. Unfortunately, many children and adolescents with diabetes do not partake in regular exercise and physical activity for multiple reasons. This review identifies the barriers to participation from the aspect of the patient, caregiver, and the healthcare provider...
July 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28789832/association-of-preterm-birth-and-small-for-gestational-age-with-metabolic-outcomes-in%C3%A2-children-and-adolescents-a-population-based-cohort-study-from-taiwan
#10
Yu-Ting Huang, Hsiang-Yu Lin, Chung-Hsing Wang, Bai-Horng Su, Che-Chen Lin
BACKGROUND: Previous studies have identified preterm birth and/or small for gestational age (SGA) as risk factors for features of the metabolic syndrome, including high blood pressure, insulin sensitivity and atherosclerosis, occurring later in life, with controversial results. We conducted this population-based cohort study to investigate metabolic outcomes in those with former preterm birth and/or SGA status in Taiwan. METHODS: Data were obtained from Taiwan's universal National Health Insurance Research Database...
July 25, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28782313/lipid-profile-in-childhood-and-youth-onset-type-2-diabetes-and-their-association-with-microvascular-complications
#11
A Amutha, R Pradeepa, K S Chella, R M Anjana, R Unnikrishnan, V Mohan
AIM: To assess the lipid profiles in childhood and youth onset type 2 diabetes (T2DM) and study their association with microvascular complications. METHODS: Clinical details of individuals with childhood and youth onset T2DM, age at diagnosis between 10 and 25 yrs (n=1340) were retrieved from electronic medical records. Lipid abnormalities were classified based on the NCEP (ATP III) guidelines and management of dyslipidemia in children and adolescents with diabetes...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28780619/evaluation-of-optic-disc-retinal-nerve-fiber-and-macular-ganglion-cell-layers-in-pediatric-diabetes
#12
Evre Pekel, Selda Ayça Altıncık, Gökhan Pekel
PURPOSE: Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls. METHODS: Sixty-three eyes of 63 pediatric diabetic patients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error...
August 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28776413/the-application-of-one-hour-static-qigong-program-to-decrease-needle-pain-of-korean-adolescents-with-type-1-diabetes-a-randomized-crossover-design
#13
Euiyeon Kim, Ji-Eun Lee, Min Sohn
The aim of this study was to describe application of a static Qigong program to decrease needle pain in Korean adolescents with type 1 diabetes and its pilot test results. The pilot study was a randomized crossover design including 26 adolescents randomized to Qigong or rest group. Participants received a 60-minute Qigong program consisted of warm up, deep breathing, imaginary, and a closing warm up. After 24-hour washout period, treatment assignments were switched. We collected before and after intervention using a self-administered questionnaire, which included the faces pain scale to assess expected and perceived pain during blood sugar testing and insulin injection and the Positive and Negative Affect Schedule...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28771435/frequency-and-risk-factors-of-depression-in-type-1-diabetes-in-a-developing-country
#14
Doaa Khater, Magdy Omar
BACKGROUND: Living with type 1 diabetes, especially in developing countries, can feel overwhelming for parents and children because constant vigilance is required for proper care with an inadequacy of resources. Our aim was to investigate the frequency and risk factors of depressive symptoms in children and adolescents with type 1 diabetes. METHODS: The study was conducted using epidemiologic studies Depression Scale Questionnaire for Children (CES-DC) on 86 patients with type 1 diabetes from the Diabetes Clinic in Alexandria University Children's Hospital, Egypt...
August 3, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28767734/prediction-of-glycaemic-control-in-young-children-and-adolescents-with-type-1-diabetes-mellitus-using-mixed-effects-logistic-regression-modelling
#15
Michiel Joost van Esdonk, Bonnie Tai, Andrew Cotterill, Bruce Charles, Stefanie Hennig
OBJECTIVES: Glycaemic control in children and adolescents with type 1 diabetes mellitus can be challenging, complex and influenced by many factors. This study aimed to identify patient characteristics that were predictive of satisfactory glycaemic control in the paediatric population using a logistic regression mixed-effects (population) modelling approach. METHODS: The data were obtained from 288 patients aged between 1 and 22 years old recorded retrospectively over 3 years (1852 HbA1c observations)...
2017: PloS One
https://www.readbyqxmd.com/read/28765261/burden-of-child-and-adolescent-obesity-on-health-services-in-england
#16
Russell M Viner, Sanjay Kinra, Dasha Nicholls, Tim Cole, Anthony Kessel, Deborah Christie, Billy White, Helen Croker, Ian C K Wong, Sonia Saxena
OBJECTIVE: To assess the numbers of obese children and young people (CYP) eligible for assessment and management at each stage of the childhood obesity pathway in England. DESIGN: Pathway modelling study, operationalising the UK National Institute for Health and Care Excellence guidance on childhood obesity management against national survey data. SETTING: Data on CYP aged 2-18 years from the Health Survey for England 2006 to 2013. MAIN OUTCOME MEASURES: Clinical obesity (body mass index (BMI) >98th centile), extreme obesity (BMI ≥99...
August 1, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28760408/relationship-between-serum-inflammatory-markers-and-vascular-function-in-a-cohort-of-adolescents-with-type-1-diabetes
#17
Etienne Sochett, Damien Noone, Michael Grattan, Cameron Slorach, Rahim Moineddin, Yesmino Elia, Farid H Mahmud, David B Dunger, Neil Dalton, David Cherney, James Scholey, Heather Reich, John Deanfield
OBJECTIVE: The contribution of inflammation to endothelial/vascular dysfunction in early Type I Diabetes (T1D) is not well understood. The objective of this study was to examine the interaction between systemic inflammation and vascular function in adolescent's with and without-T1D. METHODS: 51 subjects from our observational cohort of adolescents with T1D (JDRF-CCTN), and 59 healthy controls (HC) were studied. Serum cytokines-chemokines were quantified using Human 41-Plex Array, and vascular function was measured by Flow Mediated Dilatation (FMD), Pulse Wave Velocity (PWV) and Blood Pressure (BP)...
July 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28750428/experiences-in-sensor-augmented-pump-therapy-in-families-with-two-children-with-type-1-diabetes-a-qualitative-study
#18
Franziska Bomba, Esther Müller-Godeffroy, Simone von Sengbusch
Background Caring for a child with type 1 diabetes is a tremendous challenge for a family. The aim of the study was to explore the experiences of transition to sensor-augmented pump therapy (SAP) in families with 2 affected children and the internal and external conditions which potentially impede or facilitate the adjustment process. Methods 5 families (9 parents, 8 children and adolescents) who used the SAP technology for 6 months were interviewed to describe their experiences. The interviews were analysed using thematic content analysis...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28745096/white-coat-adherence-occurs-in-adolescents-with-type-1-diabetes-receiving-intervention-to-improve-insulin-pump-adherence-behaviors
#19
Kimberly A Driscoll, Yuxia Wang, Suzanne Bennett Johnson, Elizabeth Gill, Nancy Wright, Larry C Deeb
BACKGROUND: To assess the occurrence of white coat adherence, defined as an increase in adherence to treatment regimens prior to a study appointment, in adolescents with type 1 diabetes (T1D) using insulin pumps and participating in a randomized adherence intervention trial. METHODS: Blood glucose monitoring (BGM) readings, carbohydrate inputs, and insulin boluses delivered were downloaded from the insulin pumps of adolescents, aged 10-18 years, at 3 consecutive T1D study visits...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28743729/obesity-is-associated-with-an-altered-hdl-subspecies-profile-among-adolescents-with-metabolic-disease
#20
W Sean Davidson, Anna Heink, Hannah Sexmith, Lawrence M Dolan, Scott M Gordon, James D Otvos, John T Melchior, Deborah A Elder, Jane Khoury, Esmond Geh, Amy S Shah
We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with type 2 diabetes (T2D). Four groups of adolescents were recruited: 1) Lean insulin sensitive (L-IS)- normal body mass index (BMI) and no insulin resistance, 2) lean insulin resistant (L-IR)- normal BMI but insulin resistance (fasting insulin levels ≥ 25 mU/ml and HOMA-IR ≥6), 3) obese insulin sensitive (O-IS)-BMI ≥ 95th percentile and no insulin resistance, and 4) obese insulin resistant (O-IR)-BMI ≥ 95th percentile and insulin resistance...
July 25, 2017: Journal of Lipid Research
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