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Type 1 diabetes in adolescent

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https://www.readbyqxmd.com/read/29242985/increasing-risk-of-psychiatric-morbidity-after-childhood-onset-type-1-diabetes-a-population-based-cohort-study
#1
Daniel Dybdal, Janne S Tolstrup, Stine M Sildorf, Kirsten A Boisen, Jannet Svensson, Anne Mette Skovgaard, Grete K Teilmann
AIMS/HYPOTHESIS: The aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes. METHODS: In a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588)...
December 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/29242622/assessment-of-disturbed-glucose-metabolism-and-surrogate-measures-of-insulin-sensitivity-in-obese-children-and-adolescents
#2
Christian L Roth, Clinton Elfers, Christiane S Hampe
BACKGROUND: With the rising prevalence of obesity and type 2 diabetes (T2D) in obese children, it is becoming imperative to detect disturbed glucose metabolism as early as possible in order to prevent T2D development. SUBJECTS/METHODS: Cross-sectional study of 92 obese children (median age 11.7 years, 51% female) and 7 lean children (median age 11.4 years, 57% female) who underwent an oral glucose tolerance test (OGTT) in a tertiary pediatric care center. Glucose tolerance was assessed and different indices for β-cell function, insulin sensitivity and insulin secretion were calculated...
December 14, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29238730/interaction-of-pubertal-development-and-metabolic-control-in-adolescents-with-type-1-diabetes-mellitus
#3
M Plamper, B Gohlke, J Woelfle, K Konrad, T Rohrer, S Hofer, W Bonfig, K Fink, R W Holl
Background: In T1DM, delayed pubertal development and reduced final height are associated with inadequate metabolic control. Objective: To assess whether T1DM affects pubertal growth spurt and whether metabolic control during puberty is gender-related. Methods: Using a large multicentre database, longitudinal data from 1294 patients were analysed. Inclusion criteria: complete records of height and HbA1c from the age of seven to 16 years. Exclusion criteria: other significant chronic diseases and medications, T1DM duration less than three months, and initial BMI < 3rd or >97th percentile...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29235225/no-change-in-type-2-diabetes-prevalence-in-children-and-adolescents-over-10-years-update-of-a-population-based-survey-in-south-germany
#4
REVIEW
A Neu, L Feldhahn, S Ehehalt, J Ziegler, U Rothe, J Rosenbauer, R W Holl
Objective of this study was to analyze prevalence changes in type 2 diabetes (T2D) among children and adolescents over the last 10 years. We performed a cross-sectional survey in Baden-Württemberg (BW), Germany, by using a written questionnaire and comparing these results with T2D prevalence data from the same area retrieved in 2004/2005. In 2016, 50 patients with T2D under 20 years of age were registered in BW, Germany, which corresponds to a prevalence rate of 2.42 per 100 000 (95% confidence interval [CI]: 1...
December 12, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29228854/the-design-and-development-of-myt1dhero-a-mobile-app-for-adolescents-with-type-1-diabetes-and-their-parents
#5
Bree E Holtz, Katharine M Murray, Denise D Hershey, Joshua Richman, Julie K Dunneback, Arpita Vyas, Michael A Wood
Introduction Type 1 diabetes impacts approximately 1.25 m Americans, many of them young children. As a child grows, there is a transition towards independence and they must learn to manage their diabetes independently. The objective of this study was to design, develop and conduct a prototype test to assess the satisfaction and feasibility of a mobile app for adolescents with type 1 diabetes and their parents to aid in this transition. Methods Ten parent/adolescent groups used MyT1DHero for four weeks. They were given a pre-test/post-test survey regarding family conflict with three tasks of diabetes management and the general tone of family communication...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29227755/glycemic-variability-percentage-a-novel-method-for-assessing-glycemic-variability-from-continuous-glucose-monitor-data
#6
Thomas A Peyser, Andrew K Balo, Bruce A Buckingham, Irl B Hirsch, Arturo Garcia
BACKGROUND: High levels of glycemic variability are still observed in most patients with diabetes with severe insulin deficiency. Glycemic variability may be an important risk factor for acute and chronic complications. Despite its clinical importance, there is no consensus on the optimum method for characterizing glycemic variability. METHOD: We developed a simple new metric, the glycemic variability percentage (GVP), to assess glycemic variability by analyzing the length of the continuous glucose monitoring (CGM) temporal trace normalized to the duration under evaluation...
December 11, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29226514/hospital-admission-in-children-and-adolescents-with-or-without-type-1-diabetes-from-germany-an-analysis-of-statutory-health-insurance-data-on-12-million-subjects
#7
Barbara Bohn, Anke Schwandt, Peter Ihle, Andrea Icks, Joachim Rosenbauer, Beate Karges, Reinhard W Holl
OBJECTIVE: To compare the chance of hospital admissions in children and adolescents with type 1 diabetes (T1D) to that without T1D from Germany. METHODS: Data were provided by the German information system for health care data which contains information on all patients with a statutory health insurance. The years 2009 and 2011 were considered. Children and adolescents (0 to ≤19 years of age; n = 12 030 242) were included. Unadjusted odds ratios (ORs) with 95% confidence interval (95% CI) were used to compare the hospitalization rate for patients with (n = 26 444) or without T1D (12 003 798)...
December 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29225894/adolescents-perceptions-of-participation-in-group-education-using-the-guided-self-determination-young-method-a-qualitative-study
#8
Anna Lena Brorsson, Anna Lindholm Olinder, Gunnel Viklund, Therese Granström, Janeth Leksell
Objective: Guided Self-Determination (GSD) is a person-centered communication and reflection method. Education in groups may have a greater impact than the content of the education, and constructive communication between parents and adolescents has been shown to be of importance. The purpose of this study was to describe adolescents' perceptions of participation in group education with the Guided Self-Determination-Young (GSD-Y) method, together with parents, in connection with the introduction of continuous subcutaneous insulin infusion...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29224132/treatment-of-mild-to-moderate-hypoglycemia-in-patients-with-type-1-diabetes-treated-with-insulin-pump-therapy-are-current-recommendations-effective
#9
Véronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valérie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Rémi Rabasa-Lhoret
AIMS: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1.5 mmol/L in 15 min. We aimed to explore the effect of current recommended treatment of mild-to-moderate hypoglycemia in type 1 diabetes (T1D) participants and factors associated with treatment effectiveness...
December 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29218837/asthma-in-children-and-adolescents-with-type-1-diabetes-in-germany-and-austria-frequency-and-metabolic-control
#10
Thomas Hörtenhuber, Wieland Kiess, Elke Fröhlich-Reiterer, Klemens Raile, Rainer Stachow, Esther Bollow, Birgit Rami-Merhar, Reinhard W Holl
OBJECTIVE: To investigate the prevalence of asthma in young patients with type 1 diabetes mellitus (T1D) from Austria and Germany and its influence on their metabolic control. METHODS: This prospective, multicenter observational cohort study was based on the DPV-registry (German/Austrian DPV initiative) including 51 926 patients with T1D (<20 years). All clinical data were documented prospectively. To identify patients with additional asthma, the entry of the diagnosis asthma as well as asthma medication was used for classification...
December 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29218780/under-treatment-of-hypertension-and-hypercholesterolemia-in-children-and-adolescents-with-type-1-diabetes-long-term-follow-up-on-time-trends-in-the-occurrence-of-cardiovascular-disease-risk-factors-and-medications-use
#11
Fariba Ahmadizar, Patrick Souverein, Anthonius de Boer, Anke H Maitland-van der Zee
AIMS: 1) To evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and occurrence of CVD events in children with type 1 diabetes mellitus (T1DM), and 2) To assess determinants of under-treatment of CVD risk factors. METHODS: A retrospective cohort study was conducted in 3,728 children (<19 years) with T1DM and up to 5 age and gender-matched diabetes-free children (reference cohort) (n=18,513) using data from the Clinical Practice Research Datalink (CPRD)...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29207795/association-between-vascular-endothelial-markers-and-carotid-intima-media-thickness-in-children-and-adolescents-with-type-1-diabetes-mellitus
#12
Noushin Rostampour, Kiavash Fekri, Elham Hashemi-Dehkordi, Mahdieh Obodiat
Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the important risk factor for cardiovascular disease. Endothelial dysfunction and increased Carotid Intima-Media Thickness (CIMT) result in cardiovascular complications. Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1) are two adhesion molecules that are markers of early atherosclerosis and play a significant role in developing atherosclerosis. Aim: To evaluate CIMT and its association with the levels of ICAM-1 and VCAM-1 in children and adolescents with T1DM...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#13
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
December 5, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29205484/subclinical-left-ventricular-systolic-and-diastolic-dysfunction-in-type-1-diabetic-children-and-adolescents-with-good-metabolic-control
#14
Tamer Yoldaş, Utku Arman Örün, Elif Sagsak, Zehra Aycan, Özkan Kaya, Senem Özgür, Selmin Karademir
OBJECTIVE: Cardiac dysfunction is a well-known consequence of diabetes mellitus. This study was designed to assess whether type 1 diabetic children and adolescents with good metabolic control have early echocardiographic signs of subclinical left ventricular dysfunction and whether diabetes duration has any influence, using conventional and nonconventional echocardiographic tools. METHODS: A total of 100 patients with type 1 diabetes mellitus and 80 gender- and age-matched healthy controls were included...
December 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/29204256/reproductive-disturbances-among-saudi-adolescent-girls-and-young-women-with-type-1-diabetes-mellitus
#15
Rim Braham, Asirvatham Alwin Robert, Maha Ali Musallam, Abdulaziz Alanazi, Nawaf Bin Swedan, Mohamed Abdulaziz Al Dawish
AIM: To identify reproductive disturbances among adolescent girls and young women with type 1 diabetes mellitus (T1DM) in Saudi Arabia. METHODS: This cross sectional study was conducted among 102 female with T1DM, (aged 13-29 years) who attended the Diabetes Clinic at Diabetes Treatment Center, Prince Sultan Military Medical City, Saudi Arabia between April 2015 to March 2016. Clinical history, anthropometric characteristics and reproductive disturbance were collected through a questionnaire...
November 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29199409/depressive-symptoms-are-negatively-associated-with-glucose-testing-and-eating-meals-on-time-among-individuals-with-diabetes-in-zambia
#16
Given Hapunda, Amina Abubakar, Frans Pouwer, Fons van de Vijver
BACKGROUND: Depression is an established risk factor for cardiovascular diseases and mortality among individuals living with diabetes, and impaired self-care behaviors may play a mediating role. In Africa, this association is not very well known. In this study, we examined the associations between depressive symptoms and different aspects of diabetes self-care in Zambian individuals with diabetes mellitus. METHODS: A total of 157 individuals with diabetes mellitus participated...
November 17, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29191844/reduction-in-hypoglycemia-with-the-predictive-low-glucose-management-system-a-long-term-randomized-controlled-trial-in-adolescents-with-type-1-diabetes
#17
Mary B Abraham, Jennifer A Nicholas, Grant J Smith, Janice M Fairchild, Bruce R King, Geoffrey R Ambler, Fergus J Cameron, Elizabeth A Davis, Timothy W Jones
OBJECTIVE: Short-term studies with automated systems that suspend basal insulin when hypoglycemia is predicted have shown a reduction in hypoglycemia; however, efficacy and safety have not been established in long-term trials. RESEARCH DESIGN AND METHODS: We conducted a 6-month, multicenter, randomized controlled trial in children and adolescents with type 1 diabetes using the Medtronic MiniMed 640G pump with Suspend before low (predictive low-glucose management [PLGM]) compared with sensor-augmented pump therapy (SAPT) alone...
November 30, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29186562/adaptation-of-an-evidence-based-diabetes-management-intervention-for-delivery-in-community-settings-findings-from-a-pilot-randomized-effectiveness-trial
#18
Deborah A Ellis, April Idalski Carcone, Sylvie Naar-King, Dixy Rajkumar, Gloria Palmisano, Kathleen Moltz
Objective: To adapt an evidence-based intervention targeting diabetes management in adolescents with poorly controlled type 1 diabetes for use in a community setting by community health workers (CHWs) and to conduct pilot testing of the new intervention, REACH for Control (RFC). The study was conducted as a collaboration between university researchers and a federally qualified health center. Methods: In a pilot effectiveness trial, feasibility and acceptability of RFC were evaluated based on participant enrollment, treatment dose, and consumer satisfaction...
November 27, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29184818/transition-of-care-for-patients-with-type-1-diabetes-mellitus-from-pediatric-to-adult-health-care-systems
#19
REVIEW
Elizabeth O Buschur, Bethany Glick, Manmohan K Kamboj
Planning for the transition from pediatric to adult healthcare is broadly understood to be beneficial to the quality of care of patients with chronic illness. Due to the level of self-care that is necessary in the maintenance of most chronic diseases, it is important that pediatric settings can offer support during a time when adolescents are beginning to take more responsibility in all areas of their lives. Lack of supportive resources for adolescents with chronic conditions often results in both decreased access to care and impaired health and function likely leading to increased medical costs later...
October 2017: Translational Pediatrics
https://www.readbyqxmd.com/read/29183909/comparison-of-%C3%AE-cell-function-between-overweight-obese-adults-and-adolescents-across-the-spectrum-of-glycemia
#20
Melinda E Chen, Aaditya G Chandramouli, Robert V Considine, Tamara S Hannon, Kieren J Mather
OBJECTIVE: Type 2 diabetes is a growing health problem among both adults and adolescents. To better understand the differences in the pathogenesis of diabetes between these groups, we examined differences in β-cell function along the spectrum of glucose tolerance. RESEARCH DESIGN AND METHODS: We evaluated 89 adults and 50 adolescents with normal glucose tolerance (NGT), dysglycemia, or type 2 diabetes (T2D). Oral glucose tolerance test results were used for C-peptide and insulin/glucose minimal modeling...
November 28, 2017: Diabetes Care
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