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Type 1 diabetes in adolescent

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https://www.readbyqxmd.com/read/28086765/health-related-quality-of-life-hrqol-and-its-associated-factors-in-children-with-type-1-diabetes-mellitus-t1dm
#1
Marta Murillo, Joan Bel, Jacobo Pérez, Raquel Corripio, Gemma Carreras, Xavier Herrero, Josep-Maria Mengibar, Dolors Rodriguez-Arjona, Ulrike Ravens-Sieberer, Hein Raat, Luis Rajmil
BACKGROUND: The objective of the study was to describe the baseline health-related quality of life (HRQOL) in a cohort of children and adolescents with type 1 diabetes mellitus (T1DM), and analyze its associated clinical and sociodemographic factors, assessing HRQOL through internet. METHODS: This was a descriptive study of 136 patients with T1DM from 5 hospitals in Catalonia, Spain (72 girls, mean age 13.4 years (range 8-19). Inclusion criteria were more than 6 months from diagnosis, more than 8 years old and without cognitive problems...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28080100/metabolic-control-and-academic-achievement-over-time-among-adolescents-with-type-1-diabetes
#2
Joel B Winnick, Cynthia A Berg, Deborah J Wiebe, Barbara A Schaefer, Pui-Wa Lei, Jonathan E Butner
The relation between metabolic control (HbA1c) and achievement (grade point average [GPA]) was examined over a period of 2.5 years (every 6 months) employing a dynamical systems approach that allowed for the examination of whether HbA1c was associated with change in subsequent GPA and vice versa. Metabolic control tends to deteriorate (i.e., with higher HbA1c reflecting poorer metabolic control) during adolescence. It was hypothesized that these higher levels of HbA1c would limit subsequent increases in GPA...
January 12, 2017: School Psychology Quarterly
https://www.readbyqxmd.com/read/28080079/mother-father-and-adolescent-self-control-and-adherence-in-adolescents-with-type-1-diabetes
#3
Amy Hughes Lansing, Rebecca Crochiere, Carrie Cueto, Deborah J Wiebe, Cynthia A Berg
This study explored whether shared self-control across a family system, including adolescent, mother, and father self-control, as well as the interaction of mother and father self-control, was associated with ease of completing adherence tasks and the completion of adherence behaviors related to the Type 1 diabetes (T1D) regimen. One hundred thirty-seven adolescents (M = 13.48 years), mothers, and fathers completed a self-report measure of self-control, while adolescents also self-reported on ease of completing adherence tasks and the frequency with which they completed adherence tasks...
January 12, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28072839/assessment-of-attention-deficits-in-adolescent-offspring-exposed-to-maternal-type-1-diabetes
#4
Birgitte Bytoft, Sine Knorr, Zuzana Vlachova, Rikke B Jensen, Elisabeth R Mathiesen, Henning Beck-Nielsen, Claus H Gravholt, Dorte M Jensen, Tine D Clausen, Erik L Mortensen, Peter Damm
OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring. RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style...
2017: PloS One
https://www.readbyqxmd.com/read/28065736/long-term-outcomes-of-bariatric-surgery-in-adolescents-with-severe-obesity-fabs-5-a-prospective-follow-up-analysis
#5
Thomas H Inge, Todd M Jenkins, Stavra A Xanthakos, John B Dixon, Stephen R Daniels, Meg H Zeller, Michael A Helmrath
BACKGROUND: Little is known about the long-term outcomes of bariatric surgery for severe adolescent obesity, raising questions about the durability of early responses to surgery. We aimed to analyse long-term (>5 years) outcomes of Roux-en-Y gastric bypass in a cohort of young adults who had undergone the operation during adolescence, in the Follow-up of Adolescent Bariatric Surgery at 5 Plus Years (FABS-5+) extension study. METHODS: A cohort of young people aged 13-21 years underwent Roux-en-Y gastric bypass for clinically severe obesity at a paediatric academic medical centre in the USA...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28065734/laparoscopic-roux-en-y-gastric-bypass-in-adolescents-with-severe-obesity-amos-a-prospective-5-year-swedish-nationwide-study
#6
Torsten Olbers, Andrew J Beamish, Eva Gronowitz, Carl-Erik Flodmark, Jovanna Dahlgren, Gustaf Bruze, Kerstin Ekbom, Peter Friberg, Gunnar Göthberg, Kajsa Järvholm, Jan Karlsson, Staffan Mårild, Martin Neovius, Markku Peltonen, Claude Marcus
BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservatively treated adolescents and of adults undergoing Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28065514/review-of-childhood-obesity-from-epidemiology-etiology-and-comorbidities-to-clinical-assessment-and-treatment
#7
REVIEW
Seema Kumar, Aaron S Kelly
Childhood obesity has emerged as an important public health problem in the United States and other countries in the world. Currently 1 in 3 children in the United States is afflicted with overweight or obesity. The increasing prevalence of childhood obesity is associated with emergence of comorbidities previously considered to be "adult" diseases including type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, and dyslipidemia. The most common cause of obesity in children is a positive energy balance due to caloric intake in excess of caloric expenditure combined with a genetic predisposition for weight gain...
January 5, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28065206/iowa-gambling-task-performance-prospectively-predicts-changes-in-glycemic-control-among-adolescents-with-type-1-diabetes
#8
Yana Suchy, Tara L Queen, Bryce Huntbach, Deborah J Wiebe, Sara L Turner, Jonathan Butner, Caitlin S Kelly, Perrin C White, Mary Murray, Michael Swinyard, Cynthia A Berg
OBJECTIVES: Good glycemic control is an important goal of diabetes management. Late adolescents with type 1 diabetes (T1D) are at risk for poor glycemic control as they move into young adulthood. For a subset of these patients, this dysregulation is extreme, placing them at risk for life-threatening health complications and permanent cognitive declines. The present study examined whether deficiency in emotional decision making (as measured by the Iowa Gambling Task; IGT) among teens with T1D may represent a neurocognitive risk factor for subsequent glycemic dysregulation...
January 9, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28063503/does-oral-glutamine-improve-insulin-sensitivity-in-adolescents-with-type-1-diabetes
#9
Lournaris Torres-Santiago, Nelly Mauras, Jobayer Hossain, Arthur L Weltman, Dominique Darmaun
OBJECTIVE: The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. METHODS: Thirteen adolescents with T1D (HbA1C 8.2 ± 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28061319/brief-computer-delivered-intervention-to-increase-parental-monitoring-in-families-of-african-american-adolescents-with-type-1-diabetes-a-randomized-controlled-trial
#10
Deborah A Ellis, April Idalski Carcone, Steven J Ondersma, Sylvie Naar-King, Bassem Dekelbab, Kathleen Moltz
BACKGROUND: African American adolescents with type 1 diabetes (T1D) are at elevated risk for poor diabetes management and metabolic control. Parental supervision and monitoring of adolescent diabetes management have been shown to promote better diabetes management among adolescents, but parents typically decrease their oversight during the transition to independent diabetes care. INTRODUCTION: The purpose of the study was to conduct a randomized clinical trial to test the feasibility and efficacy of a three-session, computer-delivered motivational intervention (The 3Ms) to promote increased parental monitoring among primary caregivers of young African American adolescents with T1D...
January 6, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28052112/lower-frequency-of-hla-drb1-type-1-diabetes-risk-alleles-in-pediatric-patients-with-mody
#11
Inés Urrutia, Rosa Martínez, Tamara López-Euba, Teresa Velayos, Idoia Martínez de LaPiscina, José Ramón Bilbao, Itxaso Rica, Luis Castaño
OBJECTIVE: The aim of this study was to determine the frequency of susceptible HLA-DRB1 alleles for type 1 diabetes in a cohort of pediatric patients with a confirmed genetic diagnosis of MODY. MATERIALS AND METHODS: 160 families with a proband diagnosed with type 1 diabetes and 74 families with a molecular diagnosis of MODY (61 GCK-MODY and 13 HNF1A-MODY) were categorized at high definition for HLA-DRB1 locus. According to the presence or absence of the susceptible HLA-DRB1 alleles for type 1 diabetes, we considered three different HLA-DRB1 genotypes: 0 risk alleles (no DR3 no DR4); 1 risk allele (DR3 or DR4); 2 risk alleles (DR3 and/or DR4)...
2017: PloS One
https://www.readbyqxmd.com/read/28050932/physical-activity-levels-of-adolescents-with-type-1-diabetes
#12
Valderi Abreu de Lima, Luis Paulo Gomes Mascarenhas, Juliana Pereira Decimo, William Cordeiro de Souza, Anna Louise Stellfeld Monteiro, Ian Lahard, Suzana Nesi França, Neiva Leite
: The aim of this study was to evaluate the level of physical activity and cardiorespiratory fitness in teenagers with type 1 diabetes mellitus (T1D) in comparison with healthy scholar participants. Total of 154 teenagers (T1D=45 and CON=109). Height, weight, cardiorespiratory fitness (VO2max), and the level of physical activity by the Bouchard's Physical Activity Record were measured, and glycated hemoglobin (HbA1c) in T1D. The VO2 max was lower in the T1D (38.38 ± 7.54) in comparison with the CON (42...
January 4, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28049242/factors-associated-with-the-presence-and-severity-of-diabetic-ketoacidosis-at-diagnosis-of-type-1-diabetes-in-korean-children-and-adolescents
#13
Hye Jin Lee, Hyeoh Won Yu, Hae Woon Jung, Young Ah Lee, Jae Hyun Kim, Hye Rim Chung, Jaeho Yoo, Eunyoung Kim, Jeesuk Yu, Choong Ho Shin, Sei Won Yang, Seong Yong Lee
The aim of this study was to identify the risk factors for presence and severity of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes mellitus (T1DM) in Korean children and adolescents. A retrospective chart review of children and adolescents newly diagnosed with T1DM was conducted in seven secondary and tertiary centers in Korea. Eligible subjects were < 20 years of age and had records on the presence or absence of DKA at the time of T1DM diagnosis. DKA severity was categorized as mild, moderate, or severe...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28039141/genotyping-of-coeliac-specific-human-leucocyte-antigen-in-children-with-type-1-diabetes-does-this-screening-method-make-sense
#14
Elisabeth Binder, Martina Loinger, Annelies Mühlbacher, Michael Edlinger, Elisabeth Steichen, Dagmar Meraner, Lorin Loacker, Guenter Weigel, Thomas Müller, Elke Fröhlich-Reiterer, Sabine E Hofer
OBJECTIVES: Due to a high linkage disequilibrium of diabetes and coeliac-specific human leucocyte antigen (HLA) genotypes, the prevalence of coeliac disease (CD) in children and adolescents with diabetes mellitus type 1 (T1D) is much higher than in the general population. Recently, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) revised new screening guidelines in which genotyping for coeliac-specific HLA alleles is recommended for high-risk patients as patients with T1D...
December 30, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28031324/overweight-and-obese-but-not-normal-weight-women-with-pcos-are-at-increased-risk-of-type-2-diabetes-mellitus-a-prospective-population-based-cohort-study
#15
M-M E Ollila, S West, S Keinänen-Kiukaanniemi, J Jokelainen, J Auvinen, K Puukka, A Ruokonen, M-R Järvelin, J S Tapanainen, S Franks, T T Piltonen, L C Morin-Papunen
STUDY QUESTION: What are the respective roles of polycystic ovary syndrome (PCOS), long-term weight gain and obesity for the development of prediabetes or Type 2 diabetes mellitus (T2DM) by age 46 years? SUMMARY ANSWER: The risk of T2DM in women with PCOS is mainly due to overweight and obesity, although these two factors have a synergistic effect on the development of T2DM. WHAT IS KNOWN ALREADY: PCOS is associated with an increased risk of prediabetes and T2DM...
December 28, 2016: Human Reproduction
https://www.readbyqxmd.com/read/28028075/an-increased-diagnostic-sensitivity-of-truncated-gad65-autoantibodies-in-type-1-diabetes-may-be-related-to-hla-dq8
#16
Axel Wester, Hanna Skärstrand, Alexander Lind, Anita Ramelius, Annelie Carlsson, Elisabeth Cedervall, Björn Jönsson, Sten A Ivarsson, Helena Elding Larsson, Karin Larsson, Bengt Lindberg, Jan Neiderud, Malin Fex, Carina Törn, Åke Lernmark
N-terminally truncated (96-585) GAD65 (tGAD65) autoantibodies may better delineate type 1 diabetes than full-length GAD65 (fGAD65) autoantibodies. We aimed to compare the diagnostic sensitivity and specificity between fGAD65 and tGAD65 autoantibodies for type 1 diabetes in relation to HLA-DQ. Sera from newly diagnosed type 1 diabetes children and adolescents (n=654) and healthy controls (n=605) were analyzed in radiobinding assays for fGAD65 (fGADA), tGAD65 (tGADA) and commercial (125)I-GAD65 (RSRGADA) autoantibodies...
December 27, 2016: Diabetes
https://www.readbyqxmd.com/read/28008003/executive-function-in-adolescents-with-type-1-diabetes-relationship-to-adherence-glycemic-control-and-psychosocial-outcomes
#17
Katia M Perez, Niral J Patel, Jadienne H Lord, Kimberly L Savin, Alexandra D Monzon, Robin Whittemore, Sarah S Jaser
OBJECTIVE : Impairments in executive function (EF) skills have been observed in youth with type 1 diabetes (T1D), and these skills are critical for following the complex treatment regimen. This study examines parent reports of EF in relation to measures of adherence, glycemic control (A1c), and psychosocial outcomes (depression and quality of life) in adolescents with T1D. METHODS : A total of 120 adolescents (aged 13-17 years, 52.5% female, 87.5% White) with T1D and their parents completed questionnaires...
December 21, 2016: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28004484/adolescent-life-with-diabetes-gender-matters-for-level-of-distress-experiences-from-the-national-tods-study
#18
Gun Forsander, Mette Bøgelund, Josephine Haas, Ulf Samuelsson
OBJECTIVE: To examine the relationship between diabetes distress and gender, and the association with glycemic control, social support, health behaviors, and socio-economic status. METHODS: All adolescents, aged 15 to 18 years, in the national, pediatric diabetes registry SWEDIABKIDS with type 1 diabetes were invited to complete an online questionnaire. A total of 2112 teenagers were identified. RESULTS: 453 complete responses were valid for analyses...
December 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/28004477/revisiting-autoimmune-gastritis-in-children-and-adolescents-with-type-1-diabetes
#19
Alix Besançon, Bénédicte Michaud, Jacques Beltrand, Tania Goncalves, Jean-Philippe Jais, Michel Polak, Lucienne Chatenoud, Jean-Jacques Robert
OBJECTIVE: Assess the frequency of anti-H(+) /K(+) adenosine triphosphatase (ATPase) autoantibodies (AAB) and symptoms of autoimmune gastritis in children and adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Anti-H(+) /K(+) ATPase AAB were measured in 402 children and adolescents (210 boys and 192 girls, 11.1 ± 4.5 years) treated for T1D (screened positive for β-cell AAB), along with search of symptoms of anemia (hemoglobin, serum iron, and ferritin levels) and gastric pain...
December 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27999883/the-pharmacokinetics-and-pharmacodynamics-of-alogliptin-in-children-adolescents-and-adults-with-type-2-diabetes-mellitus
#20
Caroline Dudkowski, Max Tsai, Jie Liu, Zhen Zhao, Eric Schmidt, Jeannie Xie
PURPOSE: The aim of this study is to determine the pharmacokinetics (PK) and pharmacodynamics (PD) of a single 12.5- or 25-mg dose of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in pediatric (children and adolescents) and adult subjects with type 2 diabetes mellitus (T2DM). METHODS: A randomized, open-label, multicenter study was conducted in pediatric and adult subjects. Subjects in two pediatric groups (children and adolescents) were randomized 1:1 to receive a single oral dose of alogliptin 12...
December 20, 2016: European Journal of Clinical Pharmacology
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