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https://www.readbyqxmd.com/read/28194829/diffusion-tensor-imaging-of-the-anterior-cruciate-ligament-graft
#1
Pieter Van Dyck, Martijn Froeling, Eline De Smet, Pim Pullens, Michaël Torfs, Peter Verdonk, Jan Sijbers, Paul M Parizel, Ben Jeurissen
PURPOSE: A great need exists for objective biomarkers to assess graft healing following ACL reconstruction to guide the time of return to sports. The purpose of this study was to evaluate the feasibility and reliability of diffusion tensor imaging (DTI) to delineate the anterior cruciate ligament (ACL) graft and to investigate its diffusion properties using a clinical 3T scanner. MATERIALS AND METHODS: DTI of the knee (b = 0, 400, and 800 s/mm(2) , 10 diffusion directions, repeated 16 times for a total of 336 diffusion-weighted volumes) was performed at 3T in 17 patients between 3 and 7 months (mean, 4 months) following ACL reconstruction...
February 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28176368/pharmacological-inhibition-of-myostatin-protects-against-skeletal-muscle-atrophy-and-weakness-after-anterior-cruciate-ligament-tear
#2
Caroline N W Wurtzel, Jonathan P Gumucio, Jeremy A Grekin, Roger K Khouri, Carol S Davis, Alan J Russell, Asheesh Bedi, Christopher L Mendias
Anterior cruciate ligament (ACL) tears are among the most frequent knee injuries in sports medicine, with tear rates in the US up to 250,000 per year. Many patients who suffer from ACL tears have persistent atrophy and weakness even after considerable rehabilitation. Myostatin is a cytokine that directly induces muscle atrophy, and previous studies rodent models and patients have demonstrated an upregulation of myostatin after ACL tear. Using a preclinical rat model, our objective was to determine if the use of a bioneutralizing antibody against myostatin could prevent muscle atrophy and weakness after ACL tear...
February 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28147215/attenuated-synovial-fluid-ghrelin-levels-are-linked-with-cartilage-damage-meniscus-injury-and-clinical-symptoms-in-patients-with-knee-anterior-cruciate-ligament-deficiency
#3
Yu-Cong Zou, Liang-Hua Chen, Yong-Liang Ye, Guang-Gang Yang, Zheng Mao, Dan-Dan Liu, Jun-Qi Chen, Jing-Jie Chen, Gang Liu
BACKGROUND: The meniscus injury and post-traumatic knee osteoarthritis (PTOA) following anterior cruciate ligament (ACL) lesions often cause great burdens to patients. Ghrelin, a recently identified 28-amino-acid peptide, has been shown to inhibit inflammation and perform as a growth factor for chondrocyte. OBJECTIVE: This study was aimed at investigating ghrelin concentration in synovial fluid and its association with the degree of meniscus injury, articular degeneration, and clinical severity in patients suffering from anterior cruciate ligament (ACL) deficiency...
December 2016: Discovery Medicine
https://www.readbyqxmd.com/read/28146402/a-multicenter-study-of-early-anti-inflammatory-treatment-in-patients-with-acute-anterior-cruciate-ligament-tear
#4
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Laura J Huston, Lee G Gammon, Darren L Johnson, Emily K Reinke, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage. PURPOSE: The purposes of this randomized study using an acute ACL injury model were to (1) evaluate the natural progression of inflammatory and chondrodegenerative biomarkers, (2) evaluate the relationship between subjective reports of pain and inflammatory and chondrodegenerative biomarkers, and (3) determine if postinjury arthrocentesis and corticosteroid injection offer the ability to alter this biochemical cascade...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28130030/biomarker-changes-in-anterior-cruciate-ligament-deficient-knees-compared-with-healthy-controls
#5
Daniel J Kaplan, Vanessa G Cuellar, Laith M Jazrawi, Eric J Strauss
PURPOSE: To establish how synovial fluid biomarker concentrations change in patients after anterior cruciate ligament (ACL) tears, with and without associated cartilage injury, with comparisons made to healthy controls. METHODS: Patients were prospectively enrolled between January 2013 and December 2014. Inclusion criteria included any patient undergoing knee arthroscopy. Patients with a confirmed ACL tear were allocated to either the ACL tear with cartilage injury group or the ACL tear without cartilage injury group based on intraoperative assessment...
January 24, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28090441/principal-component-analysis-t1%C3%AF-voxel-based-relaxometry-of-the-articular-cartilage-a-comparison-of-biochemical-patterns-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#6
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27753626/a-unique-antiphospholipid-assay-recognizing-phospholipid-mixture-compared-with-criteria-antiphospholipid-immunoassays-in-lupus-patients
#7
Y Zuo, R Willis, E Papalardo, M Petri, E N Harris, A Schleh, K DeCeulaer, M Smikle, L M Vilá, J D Reveille, G S Alarcón, E B Gonzalez
BACKGROUND: While essential for the classification of antiphospholipid syndrome (APS), anticardiolipin (aCL) assays lack specificity and anti-β2glycoproteinI (anti-β2GPI) assays lack sensitivity in this regard. Our aim was to perform a comparative analysis of the APhL ELISA assay (IgG/IgM) and criteria antiphospholipid (aPL) immunoassays in identifying APS-related clinical manifestations in a large group of patients with systemic lupus erythematosus (SLE). METHODS: Serum samples from 1178 patients from the Hopkins (n = 543), LUMINA (n = 588) and Jamaican SLE cohorts (n = 47) were examined for IgG/IgM positivity in aCL (in-house), anti-β2GPI (two commercial kits) and APhL (Louisville APL) ELISA assays...
October 16, 2016: Lupus
https://www.readbyqxmd.com/read/27563836/composite-metric-r2-%C3%A2-%C3%A2-r1%C3%AF-1-t2-%C3%A2-%C3%A2-1-t1%C3%AF-as-a-potential-mr-imaging-biomarker-associated-with-changes-in-pain-after-acl-reconstruction-a-six-month-follow-up
#8
Colin Russell, Valentina Pedoia, Sharmila Majumdar
This study looked to investigate a new quantitative metric, R2  - R1ρ (1/T2  - 1/T1ρ ), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T1ρ /T2 protocol to calculate R1ρ (1/T1ρ ) and R2 (1/T2 ) values at baseline and 6 months after reconstructive surgery...
August 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27557479/analysis-of-the-articular-cartilage-t1%C3%AF-and-t2-relaxation-times-changes-after-acl-reconstruction-in-injured-and-contralateral-knees-and-relationships-with-bone-shape
#9
Valentina Pedoia, Favian Su, Amano Keiko, Li Qi, Charles E McCulloch, Richard B Souza, Thomas M Link, C Benjamin, Xiaojuan Li
The objectives of this study were twofold: (1) to evaluate the longitudinal change in cartilage T1ρ and T2 6- and 12-months after ACL reconstruction (ACLR) in both reconstructed and intact contralateral knees with the aim of validating the role of the contralateral knee as an internal control in longitudinal studies; (2) to explore relationships between bone shape at the time of injury and the progression of T1ρ and T2 over 12-months after ACLR. T1ρ and T2 cartilage relaxation times and 3D MRI-based Statistical Shape Modeling (SSM) of tibia and femur were computed for both knees of forty ACL-injured patients and fifteen healthy controls...
August 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27306867/review-of-current-understanding-of-post-traumatic-osteoarthritis-resulting-from-sports-injuries
#10
Andrew Carbone, Scott Rodeo
Certain types of joint injuries, common in athletes, are known to have a high association with the development of osteoarthritis (OA). Post-traumatic osteoarthritis (PTOA) is especially debilitating due to its earlier onset than traditional OA, and its predisposition to affect a younger and more active population. Five common athletic injuries have been demonstrated to be risk factors for the development of OA. These include ACL rupture, meniscus tear, glenohumeral instability, patellar dislocation, and ankle instability...
June 16, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27279368/logistical-challenges-and-design-considerations-for-studies-using-acute-anterior-cruciate-ligament-injury-as-a-potential-model-for-early-posttraumatic-osteoarthritis
#11
Christian Lattermann, Cale A Jacobs, Mary Proffitt Bunnell, Kate Jochimsen, John Abt, Emily K Reinke, Lee Gammon, Janet L Huebner, Virginia B Kraus, Kurt P Spindler
Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resulting in a shift of focus towards the young, ACL injured patients at risk of developing PTOA. Randomized clinical trials examining the very early phase after ACL injury are ideal to study this population; however, these trials face significant challenges regarding recruitment as well as reproducibility of patient-reported outcomes (PROs) and inflammatory and/or chondrodegenerative biomarkers associated with early PTOA...
June 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27159304/the-association-between-serum-biomarkers-of-collagen-turnover-and-subsequent-anterior-cruciate-ligament-rupture
#12
Steven J Svoboda, Brett D Owens, Travis M Harvey, Patrick M Tarwater, William F Brechue, Kenneth L Cameron
BACKGROUND: No study has attempted to associate the levels of preinjury serum biomarkers of collagen turnover with the subsequent risk of anterior cruciate ligament (ACL) injury. HYPOTHESIS: Preinjury serum biomarkers of collagen turnover would be associated with the subsequent risk of ACL injury. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: We conducted a case-control study with 45 ACL-injured cases and 45 controls matched for sex, age, height, and weight...
July 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27061359/american-society-of-biomechanics-clinical-biomechanics-award-2015-mri-assessments-of-cartilage-mechanics-morphology-and-composition-following-reconstruction-of-the-anterior-cruciate-ligament
#13
COMMENT
Jarred Kaiser, Michael F Vignos, Fang Liu, Richard Kijowski, Darryl G Thelen
BACKGROUND: The pathogenesis of osteoarthritis following anterior cruciate ligament (ACL) reconstruction is currently unknown. The study purpose was to leverage recent advances in quantitative and dynamic MRI to test the hypothesis that abnormal joint mechanics within four years of reconstruction is accompanied by evidence of early compositional changes in cartilage. METHODS: Static MR imaging was performed bilaterally on eleven subjects with an ACL reconstruction (1-4years post-surgery) and on twelve healthy subjects to obtain tibial cartilage thickness maps...
2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/26944669/early-cartilage-changes-after-anterior-cruciate-ligament-injury-evaluation-with-imaging-and-serum-biomarkers-a-pilot-study
#14
Riann M Palmieri-Smith, Edward M Wojtys, Hollis G Potter
PURPOSE: To determine if magnetic resonance imaging markers of cartilage matrix and morphology and circulating serum biomarkers of inflammation and matrix degradation differ over time in patients with anterior cruciate ligament (ACL) injury and bone marrow edema lesions (BMELs) when compared with matched control subjects. METHODS: We performed a case-control study, in which 11 ACL-injured subjects scheduled to undergo reconstruction and 11 matched control subjects were scheduled for testing...
July 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/26915609/potential-risk-factors-associated-with-vascular-diseases-in-patients-receiving-treatment-for-hypertension
#15
Hyunjung Kim, Joonhong Park, Hyojin Chae, Gun Dong Lee, Sang Yoon Lee, Jong Min Lee, Yong Seog Oh, Myungshin Kim, Yonggoo Kim
BACKGROUND: Currently, the hypertension (HTN) patients undergo appropriate medical treatment, and traditional risk factors are highly controlled. Therefore, potential risk factors of atherosclerotic vascular diseases (AVD) and venous thromboembolisms (VTE) in HTN should be reconsidered. We investigated thrombophilic genetic mutations and existing biomarkers for AVD or VTE in HTN patients receiving treatment. METHODS: A total of 183 patients were enrolled: AVD with HTN (group A, n=45), VTE with HTN (group B, n=62), and HTN patients without any vascular diseases (group C, n=76)...
May 2016: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/26832966/lectin-binding-of-human-sperm-associates-with-defb126-mutation-and-serves-as-a-potential-biomarker-for-subfertility
#16
Aijie Xin, Li Cheng, Hua Diao, Yancheng Wu, Shumin Zhou, Changgen Shi, Yangyang Sun, Peng Wang, Shiwei Duan, Jufen Zheng, Bin Wu, Yao Yuan, Yihua Gu, Guowu Chen, Xiaoxi Sun, Huijuan Shi, Shengce Tao, Yonglian Zhang
Coating on the sperm surface, glycocalyx, plays a key role in sperm motility, maturation and fertilization. A comprehensive profile of sperm surface glycans will greatly facilitate both basic researches and clinical studies. Because of the capability of recognizing different glycan moieties, lectins are widely used in glycobiology. However, lacking high-throughput technology, limited lectins have been reported for analyzing the glycan of human sperm. In this study, we employed a lectin microarray for profiling the surface glycans of human sperm, on which 54 out of 91 lectins showed positive binding...
February 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26797700/low-versus-high-intensity-plyometric-exercise-during-rehabilitation-after-anterior-cruciate-ligament-reconstruction
#17
RANDOMIZED CONTROLLED TRIAL
Terese L Chmielewski, Steven Z George, Susan M Tillman, Michael W Moser, Trevor A Lentz, Peter A Indelicato, Troy N Trumble, Jonathan J Shuster, Flavia M Cicuttini, Christiaan Leeuwenburgh
BACKGROUND: Plyometric exercise is used during rehabilitation after anterior cruciate ligament (ACL) reconstruction to facilitate the return to sports participation. However, clinical outcomes have not been examined, and high loads on the lower extremity could be detrimental to knee articular cartilage. PURPOSE: To compare the immediate effect of low- and high-intensity plyometric exercise during rehabilitation after ACL reconstruction on knee function, articular cartilage metabolism, and other clinically relevant measures...
March 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26713594/acute-management-of-anterior-cruciate-ligament-injuries-using-novel-canine-models
#18
Chantelle C Bozynski, James P Stannard, Pat Smith, Bryan T Hanypsiak, Keiichi Kuroki, Aaron Stoker, Cristi Cook, James L Cook
The objective of this study was to compare treatment options for acute management of anterior cruciate ligament (ACL) injuries using preclinical models. Twenty-seven adult purpose-bred research hounds underwent knee surgery (sham control, exposed ACL, or partial-tear ACL) and were assessed over the following 8 weeks. Dogs were randomized into three treatment groups: standard of care (i.e., rest and nonsteroidal anti-inflammatory drugs [NSAIDs]), washout, or leukoreduced platelet-rich plasma (PRP) so that a total of nine dogs received each treatment...
October 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/26684662/greater-mechanical-loading-during-walking-is-associated-with-less-collagen-turnover-in-individuals-with-anterior-cruciate-ligament-reconstruction
#19
COMPARATIVE STUDY
Brian Pietrosimone, J Troy Blackburn, Matthew S Harkey, Brittney A Luc, Anthony C Hackney, Darin A Padua, Jeffrey B Driban, Jeffrey T Spang, Joanne M Jordan
BACKGROUND: Individuals who have sustained an anterior cruciate ligament (ACL) injury and undergo ACL reconstruction (ACLR) are at higher risk of developing knee osteoarthritis. It is hypothesized that altered knee loading may influence the underlying joint metabolism and hasten development of posttraumatic knee osteoarthritis. PURPOSE: To explore the associations between serum biomarkers of cartilage metabolism and peak vertical ground-reaction force (vGRF) and vGRF loading rate in the injured and uninjured limbs of individuals with ACLR...
February 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26462893/-estimation-of-venous-thromboembolism-risk-with-thrombotic-biomarkers-in-cancer-patients
#20
Men Jianlong, Zhong Diansheng, Ren Jing
OBJECTIVE: To assess the value of thrombotic biomarkers in estimation of venous thromboembolism (VTE) risk in cancer patients. METHODS: A total of 1473 cancer patients treated in the Tianjin Medical University General Hospital from 2009 to 201 were selected, including 845 males and 628 females in the age of 56 ± 17 years. The activities of von Willebrand factor antigen (vWF:Ag), factor VII (F VII:A), factor VIII (F VIII:A), antithrombin (AT:A), protein C (PC:A) and protein S (PS:A) were assayed using an ACL TOP 700 blood coagulation analyzer...
April 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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