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Knee Osteoarthritis

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https://www.readbyqxmd.com/read/28431145/long-term-effects-of-a-lifestyle-intervention-and-oral-glucosamine-sulphate-in-primary-care-on-incident-knee-oa-in-overweight-women
#1
Bastiaan C de Vos, Marieke L A Landsmeer, Marienke van Middelkoop, Edwin H G Oei, Marjolein Krul, Sita M A Bierma-Zeinstra, Jos Runhaar
Objectives.: The present study was designed to evaluate the effect of a lifestyle intervention aimed to reduce body weight and of oral glucosamine sulphate on the incidence of knee osteoarthritis (OA) after 6-7 years in a population of middle-aged, overweight women, without knee OA at baseline. Methods.: The Prevention of knee Osteoarthritis in Overweight Females study, ISRCTN42823086, was a randomized controlled trial with a 2 × 2 factorial design. Four hundred and seven women aged 50-60 years with a BMI of ⩾27 kg/m 2 and free of knee OA were randomized...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28431129/cooled-radiofrequency-ablation-of-the-genicular-nerves-for-chronic-pain-due-to-knee-osteoarthritis-six-month-outcomes
#2
Zachary L McCormick, Marc Korn, Rajiv Reddy, Austin Marcolina, David Dayanim, Ryan Mattie, Daniel Cushman, Meghan Bhave, Robert J McCarthy, Dost Khan, Geeta Nagpal, David R Walega
Objective. : Determine outcomes of cooled radiofrequency ablation (C-RFA) of the genicular nerves for treatment of chronic knee pain due to osteoarthritis (OA). Design. : Cross-sectional survey. Setting.:  Academic pain medicine center. Subjects.:  Consecutive patients with knee OA and 50% or greater pain relief following genicular nerve blocks who underwent genicular nerve C-RFA. Methods.:  Survey administration six or more months after C-RFA...
April 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28430581/association-between-en1-rs4144782-and-susceptibility-of-knee-osteoarthritis-a-case-control-study
#3
Li Haohuan, Zhang Xiaolong, Cao Yiping, Hu Song, Peng Fei, Zhou Jianlin, Li Jianping
Osteoarthritis (OA) is a complex disease that affects the whole joint, resulting from the combined influence of biomechanical factors and genetic factors. The heritable component for primary OA accounts for about 60% of variation in population liability to the disease. So far, genome-wide association studies (GWAS) and candidate gene studies have established many OA-related loci. However, these findings account for only a rather small fraction of the genetic component. To further reveal the genetic architecture of OA, we conducted this case-control study to explore the association of locus EN1 rs4144782 and knee OA susceptibility in a Chinese population...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429967/knee-arthroscopic-surgery-in-middle-aged-patients-with-meniscal-symptoms-a-3-year-follow-up-of-a-prospective-randomized-study
#4
Håkan Gauffin, Sofi Sonesson, Andreas Meunier, Henrik Magnusson, Joanna Kvist
BACKGROUND: The optimal treatment for middle-aged patients with knee pain and meniscal lesions has been extensively debated. Most previous studies have revealed only short-term beneficial results of knee arthroscopic surgery. The authors have previously shown a positive benefit of knee arthroscopic surgery and an exercise program after 1 year when compared with an exercise program alone. PURPOSE: To evaluate if knee arthroscopic surgery combined with an exercise program provided an additional long-term benefit after 3 years compared with an exercise program alone in middle-aged patients with meniscal symptoms...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28429403/accuracy-of-computed-tomographic-arthrography-for-assessment-of-articular-cartilage-defects-in-the-ovine-stifle
#5
Fanny Hontoir, Peter Clegg, Vincent Simon, Nathalie Kirschvink, Jean-Francois Nisolle, Jean-Michel Vandeweerd
Articular cartilage defects are one of the features of osteoarthritis in animals and humans. Early detection of cartilage defects is a challenge in clinical veterinary practice and also in translational research studies. An accurate, diagnostic imaging method would be desirable for detecting and following up lesions in specific anatomical regions of the articular surface. The current prospective experimental study aimed to describe the accuracy of computed tomographic arthrography (CTA) for detecting cartilage defects in a common animal model used for osteoarthritis research, the ovine stifle (knee, femoropatellar/femorotibial) joint...
April 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28429341/hyalone%C3%A2-in-the-treatment-of-symptomatic-hip-oa-data-from-the-antiage-register-seven-years-of-observation
#6
A Migliore, U Massafra, B Frediani, E Bizzi, E Sinelnikov Yzchaki, G Gigliucci, M Cassol, S Tormenta
OBJECTIVE: Several studies on knee osteoarthritis suggest that the intra-articular administration of hyaluronic acid products may be a relevant option in the management of patients with persistent pain. The aim of this study is to report the data of efficacy of US-guided HyalOne®/Hyalubrix® 60 injections in a large population of patients with hip osteoarthritis, repeated at least 2 times per year for up to seven years. PATIENTS AND METHODS: This is a prospective, post-marketing, cohort study...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28428674/comparison-of-clinical-and-radiological-parameters-at-knee-osteoarthritis
#7
Adnana Talic-Tanovic, Zoran Hadziahmetovic, Ivanka Madjar-Simic, Adnan Papovic
INTRODUCTION: Osteoarthritis (OA) or arthrosis represents an inflammatory disease of joints that develops as a result of interaction of mechanical and biological parameters. With disease development, degenerative changes on joint cartilage can be noticeable that affect and cause pathological changes on other parts of a joint resulting in pain and dysfunction of a joint. A. E. Garrod in 1907 described osteoarthritis as a special clinical entity and separated it from a rheumatoid arthritis...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28428621/osteoarthritis-metabolic-syndrome-and-risk-of-knee-oa
#8
Sarah Onuora
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28428036/giantcell-tumor-of-tendon-sheath-open-surgery-or-arthroscopic-synovectomy-a-systematic-review-of-the-literature
#9
REVIEW
Thibaut Noailles, Kevin Brulefert, Sylvain Briand, Pierre Marie Longis, Kevin Andrieu, Antoine Chalopin, François Gouin
PURPOSE: Giantcell tumor of tendon sheath(GCTTS)formelyknowned as pigmented villonodular synovitis (PVNS) is a benign, locally aggressive, proliferative disorder of the synovium involving a joint, bursa, or tendon sheath. Treatment ofGCTTSinvolves early surgical resection to limit articular destruction and the risk of recurrence. Synovectomy remains the treatment of choice forGCTTSbut without clear consensus to make an open or arthroscopic synovectomy andno certainty on the responsibility of surgery in the evolution towards the degenerative osteoarthritis...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28427806/decreased-synovial-fluid-ghrelin-levels-are-linked-with-disease-severity-in-primary-knee-osteoarthritis-patients-and-are-increased-following-laser-therapy
#10
Yu-Cong Zou, Hong-Yu Deng, Zheng Mao, Chang Zhao, Ju Huang, Gang Liu
BACKGROUND: Ghrelin has been proved to inhibit inflammation and promote cartilage growth. So far, its role in patients with primary osteoarthritis has not been investigated. OBJECTIVE: The current study was performed to explore the serum and synovial ghrelin levels as well as the relationship between ghrelin levels and disease severity in primary knee OA patients. METHODS: 52 primary knee OA patients were recruited in the study. 52 sex and age-matched patients visiting our hospital for regular body check were selected as controls...
April 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28426917/internet-cognitive-behaviour-therapy-for-depression-in-older-adults-with-knee-osteoarthritis-a-randomized-controlled-trial
#11
Kathleen A O'Moore, Jill M Newby, Gavin Andrews, David J Hunter, Kim Bennell, Jessica Smith, Alishia D Williams
Objective To determine the efficacy of an internet-based cognitive behavioural therapy (iCBT) program for depression in older adults with osteoarthritis of the knee and comorbid major depressive disorder (MDD). We conducted a RCT in sixty-nine adults (≥ 50 years) meeting criteria for MDD and osteoarthritis of the knee with 1-week post intervention (week 11) and 3-month follow-up (week 24) end points. Patients were allocated to either a 10-week iCBT program for depression added to treatment as usual (TAU) or to a TAU control group...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28426786/t140-blocks-the-sdf-1-cxcr4-signaling-pathway-and-prevents-cartilage-degeneration-in-an-osteoarthritis-disease-model
#12
Kun Wang, Yanlin Li, Rui Han, Guofeng Cai, Chuan He, Guoliang Wang, Di Jia
Osteoarthritis (OA) is one of the most common diseases affecting older people; however, there remains no effective targeted drug to combat OA. The aims of this study were (1) to explore the effect of T140 in regulating degeneration of articular cartilage in vivo by targeted blocking of the SDF-1/CXCR4 signaling pathway, and (2) to provide experimental evidence for the development of a novel OA-targeted pharmacotherapy. Thirty-six healthy Hartley guinea pigs were randomly divided into three groups: a T140-treated group (n = 12), a phosphate buffer saline control group (n = 12) and an untreated control group (n = 12)...
2017: PloS One
https://www.readbyqxmd.com/read/28425672/evaluating-therapeutic-effect-on-womac-subscales-in-osteoarthritis-rcts-when-model-choice-matters
#13
Giulia Lorenzoni, Danila Azzolina, Nicola Soriani, Dario Gregori
RATIONALE, AIMS, AND OBJECTIVES: The study aimed at developing a method for modelling the Western Ontario and McMaster Universities index (WOMAC), accounting for correlation between its subscales and for heterogeneity of treatment effect (HTE), using data from 2 twin trials on knee osteoarthritis. METHOD: Two randomized, double-blind, placebo-controlled clinical trials (twin trials). Studies aimed at investigating the effectiveness of a pharmacological treatment on clinical outcomes of knee osteoarthritis, measured using WOMAC index...
April 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28425275/associations-between-obesity-and-the-radiographic-phenotype-in-knee-osteoarthritis
#14
Mehmet Derya Demirağ, Seçil Özkan, Şeminur Haznedaroğlu, Evin Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Göker
BACKGROUND/AIM: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. MATERIALS AND METHODS: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28423287/microfracture-versus-autologous-chondrocyte-implantation-for-articular-cartilage-lesions-in-the-knee-a-systematic-review-of-5-year-outcomes
#15
Matthew J Kraeutler, John W Belk, Justin M Purcell, Eric C McCarty
BACKGROUND: Microfracture (MFx) and autologous chondrocyte implantation (ACI) are 2 surgical treatment options used to treat articular cartilage injuries of the knee joint. PURPOSE: To compare the midterm to long-term clinical outcomes of MFx versus ACI for focal chondral defects of the knee. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to locate studies (level of evidence I-III) comparing the minimum average 5-year clinical outcomes of patients undergoing MFx versus ACI...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28421358/vitamin-d-supplementation-for-the-management-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#16
Salman Hussain, Ambrish Singh, Mohd Akhtar, Abul Kalam Najmi
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed(®), Embase(®), and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
April 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28420499/the-associations-between-parity-other-reproductive-factors-and-osteoarthritis-in-women-aged-over-50-years-data-from-the-korean-national-health-and-nutrition-examination-survey-v-2010-2012
#17
Su Mi Kim, Ju-Young Cheon, Yong-Gyu Park, Hae-Rim Kim, Jong Chul Shin, Hyun Sun Ko
OBJECTIVE: To evaluate the relationships between sociodemographic factors, reproductive history, and subsequent risk of osteoarthritis (OA) or pain of the hip, knee, and back in Korean women. MATERIALS AND METHODS: This study included data of 5101 women aged over 50 years, taken from the Korean National Health and Nutritional Examination Survey V from 2010 to 2012. Women were stratified according to parity, as well as delivery mode. Multivariate logistic regression analysis was conducted to evaluate relationships between radiographic OA or symptomatically possible OA (back, knee, or hip), and historical factors...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28420447/ck2-1-a-bone-morphogenetic-protein-receptor-type-ia-mimetic-peptide-repairs-cartilage-in-mice-with-destabilized-medial-meniscus
#18
Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B Kirn Safran, Anja Nohe
BACKGROUND: Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone morphogenetic protein receptor type I (BMPRI) mimetic peptide, CK2.1, that activates BMPRIa signaling in the absence of bone morphogenetic protein (BMP). Our previous research demonstrated that CK2.1 induced chondrogenesis in vitro and in vivo; however, it is unknown if CK2...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28420082/can-early-rehabilitation-prevent-posttraumatic-osteoarthritis-in-the-patellofemoral-joint-after-anterior-cruciate-ligament-rupture-understanding-the-pathological-features
#19
Nai-Jen Chang, Ming-You Shie, Kuan-Wei Lee, Pei-Hsi Chou, Chih-Chan Lin, Chih-Jou Chu
Knee instability resulting from anterior cruciate ligament (ACL) rupture is a high-risk factor for posttraumatic osteoarthritis (PTOA) in the patellofemoral joint (PFJ). However, whether non-weight-bearing and weight-bearing treatments have chondroprotective effects remains unclear. Twenty-four adult New Zealand White male rabbits were employed in this study. All animals received ACL transection in the right knee and sham surgery in the left knee. The rabbits were randomly assigned to the following groups: (I) In the sedentary (SED) group, the rabbits (n = 6) were simply kept in their cage; (II) In the continuous passive motion (CPM) group, the rabbits (n = 6) performed CPM exercise for 7 days, starting from the first postoperative day; (III) In the active treadmill exercise (TRE) group, the rabbits (n = 6) performed TRE for 2 weeks; (IV) In the CPM + TRE group, the rabbits (n = 6) executed CPM exercise, followed by TRE...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28419816/high-rate-of-osteoarthritis-after-osteochondritis-dissecans-fragment-excision-compared-with-surgical-restoration-at-a-mean-16-year-follow-up
#20
Thomas L Sanders, Ayoosh Pareek, Mitchel R Obey, Nicholas R Johnson, James L Carey, Michael J Stuart, Aaron J Krych
BACKGROUND: Osteochondritis dissecans (OCD) is a disorder of subchondral bone that causes adverse effects on the overlying cartilage and commonly affects the knee. The incidence of OCD and its long-term effect on the knee joint are controversial. Hypothesis/Purpose: The purpose of this study was to (1) evaluate the rate of osteoarthritis and knee arthroplasty in a population-based cohort of patients with OCD lesions treated operatively and (2) evaluate factors that may predispose patients to knee osteoarthritis and arthroplasty...
April 1, 2017: American Journal of Sports Medicine
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