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Knee Osteoarthritis

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https://www.readbyqxmd.com/read/29141359/-analysis-of-the-tibial-baseplate-coverage-and-symmetrical-tibial-prosthesis-in-primary-total-knee-arthroplasty
#1
C L Zhao, J P Wang, Z H Sun, M Li, J W Chen
Objective: To investigate the tibial baseplate coverage with symmnetrical tibial prosthesis in primary total knee arthroplasty (TKA). Methods: From August 2014 to February 2015, 39 patients (39 knees) with varus knee osteoarthritis were retrospective reviewed in Department of Orthopaedics, Tianjin Xiqing Hospital. Nine males and 30 females; aged 50 to 78 years (67±6 year). 3D tibia models of the knee were built with Mimics 10.01 software, simulated TKA surgeries were performed. The morphology of the proximal tibia was measured, including the mediolateral (ML), anteroposterior (AP) and medial and lateral tibial plateau AP dimensions...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141358/-effect-of-different-tourniquet-releasing-strategy-on-blood-loss-in-total-knee-arthroplasty
#2
Y Li, M Lu, H Tian, Z J Li, K Zhang
Objective: To explore the influences on peri-operative blood loss and postoperative blood transfusion in primary total knee arthroplasty when using different methods to release the pneumatic tourniquet. Methods: From January 2015 to December 2016, 484 patients with osteoarthritis were enrolled, undergoing primary unilateral total knee arthroplasty in the Orthopedics Department of Peking University Third Hospital. Retrospective data was used, and all the patients had been operated on by three independent working groups...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29140738/do-outcomes-of-osteochondral-allograft-transplantation-differ-based-on-age-and-sex-a-comparative-matched-group-analysis
#3
Rachel M Frank, Eric J Cotter, Simon Lee, Sarah Poland, Brian J Cole
BACKGROUND: The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed. PURPOSE: To determine clinical outcomes for male and female patients aged ≥40 years undergoing OCA compared with a group of patients aged <40 years. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29139576/effects-of-lateral-offset-sole-shoes-on-knee-adduction-moment-in-women-with-medial-compartment-knee-osteoarthritis
#4
Woo Young Jang, Hae Woon Jung, Gi Won Choi, Hyun Min Lee, Hae Soo Park, Soon Hyuck Lee
This study aimed to determine the impact of wearing a lateral-offset sole shoe (LOSS) on knee adduction moment (KAM) in patients with medial knee osteoarthritis (OA). From December 2012 to November 2016, patients with medial knee OA were recruited. Ninety-three knees (50 left, 43 right) of 93 female patients were analyzed. The first peak KAMs were measured with patients 1) walking barefoot, 2) walking in conventional shoes, and 3) walking in LOSSs. The patients had grade 1 (n=19), grade 2 (n=49), grade 3 (n=20), and grade 4 (n=5) knee OA...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29139573/gait-patterns-symptoms-and-function-in-patients-with-isolated-tibiofemoral-osteoarthritis-and-combined-tibiofemoral-and-patellofemoral-osteoarthritis
#5
Harvi F Hart, Kay M Crossley, Michael A Hunt
The purpose of this study was to compare hip and knee biomechanics during walking in individuals with isolated TFOA, combined TFOA and PFOA, and those without knee OA, and to compare patient-reported symptoms and function in individuals with isolated TFOA and those with combined TFOA and PFOA. Participants with and without knee OA were assessed and categorized into (i) no OA, (ii) isolated TFOA, and (iii) combined TFOA and PFOA, based on Kellgren and Lawrence diagnostic criteria. Quantitative motion analyses were conducted during walking, and hip and knee kinematics and external moments were calculated...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29137947/low-dose-vitamin-d-supplementation-and-incident-frailty-in-older-people-an-eight-year-longitudinal-study
#6
Francesco Bolzetta, Brendon Stubbs, Marianna Noale, Alberto Vaona, Jacopo Demurtas, Stefano Celotto, Alberto Cester, Stefania Maggi, Ai Koyanagi, Emanuele Cereda, Nicola Veronese
Hypovitaminosis D is associated with frailty, but if vitamin D supplementation may prevent the onset of frailty is poorly known. Therefore, we aimed to investigate whether vitamin D supplementation is associated with a lower risk of frailty. In this longitudinal study, 4,421 individuals at high risk or having knee osteoarthritis free from frailty at baseline (mean age: 61.3, females=58.0%) were followed for 8 years. Details regarding vitamin D supplementation were captured by asking whether the participant took vitamin D during the previous year, at least once per month...
November 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29137899/joint-gap-in-mid-flexion-is-not-a-predictor-of-postoperative-flexion-angle-after-total-knee-arthroplasty
#7
Yukihide Minoda, Shigeru Nakagawa, Ryo Sugama, Tessyu Ikawa, Takahiro Noguchi, Masashi Hirakawa
BACKGROUND: Postoperative knee flexion angle is one of the most important outcomes of total knee arthroplasty (TKA). Intraoperative ligament balancing may affect the postoperative range of motion of the knee. However, the relationship between intraoperative ligament balancing and postoperative flexion angle was still controversial. The purpose of this study was to determine whether intraoperative joint gap affects postoperative knee flexion angle or not. METHODS: Prospective multicenter study of 246 knees with varus osteoarthritis undergoing a posterior-stabilized, mobile-bearing TKA was performed...
November 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29137696/effects-of-self-knee-massage-with-ginger-oil-in-patients-with-osteoarthritis-an-experimental-study
#8
Betul Tosun, Nursemin Unal, Deniz Yigit, Nuray Can, Ozlem Aslan, Servet Tunay
BACKGROUND AND PURPOSE: The purpose of our study was to assess the effects of self-knee massage with ginger oil on pain and daily living activities in patients with knee osteoarthritis. METHODS: Participants (N = 68) were asked about their sociodemographic characteristics, pain level in the last week using the Visual Analog Scale (VAS), and functionality in activities of daily living with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)...
November 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29137611/diagnostic-validity-and-triage-concordance-of-a-physiotherapist-compared-to-physicians-diagnoses-for-common-knee-disorders
#9
S Décary, M Fallaha, B Pelletier, P Frémont, J Martel-Pelletier, J-P Pelletier, D E Feldman, M-P Sylvestre, P-A Vendittoli, F Desmeules
BACKGROUND: Emergence of more autonomous roles for physiotherapists warrants more evidence regarding their diagnostic capabilities. Therefore, we aimed to evaluate diagnostic and surgical triage concordance between a physiotherapist and expert physicians and to assess the diagnostic validity of the physiotherapist's musculoskeletal examination (ME) without imaging. METHODS: This is a prospective diagnostic study where 179 consecutive participants consulting for any knee complaint were independently diagnosed and triaged by two evaluators: a physiotherapist and one expert physician (orthopaedic surgeons or sport medicine physicians)...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29137610/hemoglobin-stimulates-the-expression-of-adamts-5-and-adamts-9-by-synovial-cells-a-possible-cause-of-articular-cartilage-damage-after-intra-articular-hemorrhage
#10
Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama, Etsuo Chosa
BACKGROUND: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of synovial tissues to produce ADAMTS family members, we examined the influence of Hb by synovial cells in an in vitro experimental system. METHODS: Synovial tissues were obtained from five young patients with meniscal injury under arthroscopic surgery...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29136797/unparalleled-sample-treatment-throughput-for-proteomics-workflows-relying-on-ultrasonic-energy
#11
Susana Jorge, J E Araújo, F M Pimentel-Santos, Jaime C Branco, Hugo M Santos, Carlos Lodeiro, J L Capelo
We report on the new microplate horn ultrasonic device as a powerful tool to speed proteomics workflows with unparalleled throughput. 96 complex proteomes were digested at the same time in 4min. Variables such as ultrasonication time, ultrasonication amplitude, and protein to enzyme ratio were optimized. The "classic" method relying on overnight protein digestion (12h) and the sonoreactor-based method were also employed for comparative purposes. We found the protein digestion efficiency homogeneously distributed in the entire microplate horn surface using the following conditions: 4min sonication time and 25% amplitude...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136765/panax-quinquefolium-saponin-inhibits-endoplasmic-reticulum-stress-induced-apoptosis-and-the-associated-inflammatory-response-in-chondrocytes-and-attenuates-the-progression-of-osteoarthritis-in-rat
#12
Jun-Jun Xie, Jian Chen, Shi-Kun Guo, Yun-Tao Gu, Ying-Zhao Yan, Wei-Jun Guo, Cheng-Lun Yao, Meng-Yun Jin, Cheng-Long Xie, Xiang Wang, Xiang-Yang Wang, Long Chen
Treatments for osteoarthritis (OA) seek to restore chondrocyte function and inhibit cell apoptosis. Panax quinquefolium saponin (PQS) is the major active ingredient of Radix panacis quinquefolii (American ginseng), and has been demonstrated to exert anti-inflammatory and anti-apoptotic effects in various diseases. However, any potential effect of PQS on the pathological process of OA remains unclear. This work aimed to explore the role of PQS in chondrocytes and to clarify its potential mechanisms. We showed that PQS treatment could protect chondrocytes against endoplasmic reticulum (ER) stress and associated apoptosis induced by interleukin (IL)-1β...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29134405/cell-type-specific-gene-expression-patterns-in-the-knee-cartilage-in-an-osteoarthritis-rat-model
#13
Michal Korostynski, Natalia Malek, Marcin Piechota, Katarzyna Starowicz
Osteoarthritis (OA) is a chronic degenerative disease that leads to joint failure, pain, and disability. Gene regulation is implicated as a driver of the imbalance between the expression of catabolic and anabolic factors that eventually leads to the degeneration of osteoarthritic cartilage. In our model, knee-joint OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate (MIA) injections. Whole-genome microarrays were used to analyse the alterations in gene expression during the time-course of OA development (at 2, 14, and 28 days post-injection) in rat knee joints...
November 13, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29134251/meniscal-repair-results-in-inferior-short-term-outcomes-compared-with-meniscal-resection-a-cohort-study-of-6398-patients-with-primary-anterior-cruciate-ligament-reconstruction
#14
Eleonor Svantesson, Riccardo Cristiani, Eric Hamrin Senorski, Magnus Forssblad, Kristian Samuelsson, Anders Stålman
PURPOSE: To compare patient reported outcome measures (PROMs) during the first postoperative year between isolated anterior cruciate ligament (ACL) reconstruction and ACL reconstruction with concomitant meniscal intervention. METHODS: Patients who underwent primary ACL reconstruction at Capio Artro Clinic, Stockholm, Sweden, between 1st Jan 2001 and 31st Dec 2014 without concomitant injuries others than meniscal and/or cartilage lesions were included. Five groups of meniscal treatment simultaneously to ACL reconstruction were established; medial meniscal (MM) resection, MM repair, lateral meniscal (LM) resection, LM repair, and MM + LM resection...
November 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29134132/abnormal-subchondral-bone-remodeling-and-its-association-with-articular-cartilage-degradation-in-knees-of-type-2-diabetes-patients
#15
Yan Chen, Yong-Can Huang, Chun Hoi Yan, Kwong Yuen Chiu, Qingjun Wei, Jingmin Zhao, X Edward Guo, Frankie Leung, William W Lu
Type 2 diabetes (T2D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile, abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis (OA). Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic (n=70) and diabetes (n=51) groups...
2017: Bone Research
https://www.readbyqxmd.com/read/29133333/barriers-and-facilitators-to-orthopaedic-surgeons-uptake-of-decision-aids-for-total-knee-arthroplasty-a-qualitative-study
#16
Samantha Bunzli, Elizabeth Nelson, Anthony Scott, Simon French, Peter Choong, Michelle Dowsey
OBJECTIVES: The demand for total knee arthroplasty (TKA) is increasing. Differentiating who will derive a clinically meaningful improvement from TKA from others is a key challenge for orthopaedic surgeons. Decision aids can help surgeons select appropriate candidates for surgery, but their uptake has been low. The aim of this study was to explore the barriers and facilitators to decision aid uptake among orthopaedic surgeons. DESIGN: A qualitative study involving face-to-face interviews...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133309/correction-dietary-intake-of-fibre-and-risk-of-knee-osteoarthritis-in-two-us-prospective-cohorts
#17
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29133185/squatting-re-education-with-lumbo-pelvic-thigh-muscles-cocontraction-improves-functional-performance-in-patellofemoral-pain-syndrome-a-case-report
#18
Nagarajan Manickaraj
Anterior knee pain with or without joint crepitus during squatting is the common clinical feature in the individuals with patellofemoral pain syndrome (PFPS). Altered lower extremity alignment and lumbo-pelvic-thigh muscles motor control is often associated with PFPS. Although current interventions recommend individual muscle activation and strength training exercises, the reported benefits of cocontraction based exercises in PFPS is limited. It might be due to the long standing hypothesis that the exercise induced cocontraction of thigh muscles may induce a negative effect by increasing the joint contact forces in individuals with knee osteoarthritis...
November 10, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29132902/histopathological-assessment-of-primary-osteoarthritic-knees-in-large-patient-cohort-reveal-the-possibility-of-several-potential-patterns-of-osteoarthritis-initiation
#19
V P Mantripragada, N S Piuzzi, T Zachos, N A Obuchowski, G F Muschler, R J Midura
OBJECTIVE: The two main objectives of the study include (1) Test the hypothesis that the lateral femoral condyle (LFC) in patients with primary OA and varus knees undergoing total knee arthroplasty (TKA) can be used as a model to better characterize varying histological features of human OA, (2) Correlate characteristic OA features using the established histopathological scoring systems (HHGS and OARSI) to understand potential histopathological patterns of OA initiation. DESIGN: Two osteochondral specimens (4×4×8mm) were collected from fifty patient's LFC at the time of TKA (total 100 specimens), who presented preserved lateral knee compartment with joint space width>2mm...
November 10, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29129999/expression-of-genes-and-their-polymorphism-influences-the-risk-of-knee-osteoarthritis
#20
Abhishek Mishra, Rajeshwar Nath Srivastava, Sachin Awasthi, Devendra Parmar, Priya Mishra
Introduction: Genetic factors including the level of expression of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-α or CALM-1 are known to be strong determinants of the osteoarthritis (OA) in Caucasian and Oriental populations. Because of high prevalence of OA in Indian population and availability of limited genetic data, we determined whether similar genetic factors are involved in Indians as well. Methods: A case control study was carried out involving 500 patients of knee OA and equal number of healthy controls...
2017: Journal of Nucleic Acids
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