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Knee Osteoarthritis

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https://www.readbyqxmd.com/read/29792926/prediction-of-midlife-hand-osteoarthritis-in-young-men
#1
Karin Magnusson, Aleksandra Turkiewicz, Simon Timpka, Martin Englund
OBJECTIVES: Improved prediction modeling in osteoarthritis (OA) may encourage risk reduction through calculation of individual and population lifetime risks. There are currently no prediction models for hand OA. Thus, we aimed to i) develop a prediction model for hand OA in men and ii) to contrast its discriminative performance to a prediction model for lung cancer and chronic obstructive pulmonary disease (COPD). METHODS: We included 40 118 men aged 18 years undergoing mandatory conscription in Sweden 1969-70...
May 21, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29792925/change-in-patient-reported-outcomes-in-patients-with-and-without-mechanical-symptoms-undergoing-arthroscopic-meniscal-surgery-a-prospective-cohort-study
#2
Kenneth Pihl, Aleksandra Turkiewicz, Martin Englund, L Stefan Lohmander, Uffe Jørgensen, Nis Nissen, Jeppe Schjerning, Jonas B Thorlund
OBJECTIVE: Patients with degenerative or traumatic meniscal tears are at high risk of developing knee osteoarthritis. We investigated if younger (≤40 years) and older (>40 years) patients with preoperative mechanical symptoms improved more in patient-reported outcomes after meniscal surgery than those without mechanical symptoms. DESIGN: Patients from Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing arthroscopic surgery for a meniscal tear completed online questionnaires before surgery, and at 12 and 52 weeks follow-up...
May 21, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#3
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791699/a-comparative-effectiveness-study-for-non-operative-treatment-methods-for-knee-osteoarthritis
#4
Frank R Kolisek, Charles Jaggard, Anton Khlopas, Assem A Sultan, Nipun Sodhi, Michael A Mont
A number of non-operative treatment options are commonly prescribed for patients presenting with degenerative osteoarthritis of the knee, where surgery is not yet recommended. However, there is a paucity of studies evaluating the comparative effectiveness of these treatment options to best inform both patients and providers. This study examined the comparative effectiveness of a home exercise program versus bracing or a combination of the two (brace-only, exercise-only, and brace and exercise cohorts) on the following: 1) objective functional measures (quadriceps muscle strength, Self-Paced Walk Test [SPWT], and Timed "Up & Go" [TUG] Test); 2) subjective functional measures (Lower Extremity Function Scale [LEFS] and Health Survey [VR-12] outcomes); 3) pain using Visual Analog Scale [VAS-10]; 4) patient metrics (patient treatment preference, perceptions, and compliance); and 5) progression to total knee arthroplasty (TKA) over a 12-week period...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29790635/the-effect-of-12-week-garlic-supplementation-on-symptom-relief-in-overweight-or-obese-women-with-knee-osteoarthritis
#5
Ahmad Salimzadeh, Elham Alipoor, Sahar Dehghani, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
AIMS: Chronic joint pain and stiffness, and functional disability, are the major debilitating features of osteoarthritis (OA). The aim of this study was to assess the effect of 12-week supplementation with a garlic supplement on knee osteoarthritis outcomes in overweight or obese women. METHODS: Seventy-six postmenopausal overweight or obese women (25≤BMI≤40 kg/m2 ) with medically diagnosed knee OA participated in this randomised double-blind, placebo-controlled, parallel-design trial...
May 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29790293/the-relationship-between-self-reported-restless-sleep-and-objectively-measured-physical-activity-in-adults-with-knee-osteoarthritis
#6
Abigail L Gilbert, Jungwha Lee, Jing Song, Pamela A Semanik, Linda S Ehrlich-Jones, C Kent Kwoh, Dorothy D Dunlop, Rowland W Chang
OBJECTIVE: Despite many health benefits of physical activity, inactivity is endemic among adults with knee osteoarthritis (KOA). Because sleep quality may be a target to improve physical activity behavior, we investigated the cross-sectional relationship between restless sleep and physical activity in participants with or at risk for KOA. METHODS: We analyzed accelerometer-measured physical activity and clinical data from Osteoarthritis Initiative (OAI) participants...
May 22, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29789912/meniscal-pathologies-on-mri-correlate-with-increased-bone-tracer-uptake-in-spect-ct
#7
Jan Rechsteiner, Michael T Hirschmann, Milos Dordevic, Anna L Falkowski, Enrique A Testa, Felix Amsler, Anna Hirschmann
OBJECTIVES: To assess the relationship of subchondral bone tracer uptake (BTU) on SPECT/CT and meniscal pathologies on MRI in patients with painful knees. METHODS: Twenty-five patients who had MRI and SPECT/CT within 3 months without knee surgery or grade ≥3 cartilage lesions were prospectively included. Maximum values of each subchondral femorotibial area were quantified and a ratio was calculated in relation to a femoral shaft reference region, which represented the BTU background activity...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789519/a-macaca-fascicularis-knee-osteoarthritis-model-developed-by-modified-hulth-combined-with-joint-scratches
#8
Xin Zhou, Lei Zhang, Xiaoguang Guo, Gang Liu, Guoyou Wang, Shijie Fu
BACKGROUND Osteoarthritis is a common degenerative disease of joints, and animal models have important significance in the investigation of this disease. The aim of this study was to develop a better method for developing osteoarthritis models in primates by comparing the modified Hulth score combined with joint scratches modeling method with others. MATERIAL AND METHODS We randomly divided 15 young male Macaca fascicularis and 3 old male Macaca fascicularis into 6 groups (n=3). Knee osteoarthritis (KOA) models were developed with different methods: modified Hulth combined with joint scratches (Group A), modified Hulth (Group B), Hulth (Group C), spontaneous models (Group D); sham-operated (Group E), and blank control (Group F)...
May 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29789406/ranking-hospitals-do-we-gain-reliability-by-using-composite-rather-than-individual-indicators
#9
Stefanie N Hofstede, Iris E Ceyisakar, Hester F Lingsma, Dionne S Kringos, Perla J Marang-van de Mheen
BACKGROUND: Despite widespread use of quality indicators, it remains unclear to what extent they can reliably distinguish hospitals on true differences in performance. Rankability measures what part of variation in performance reflects 'true' hospital differences in outcomes versus random noise. OBJECTIVE: This study sought to assess whether combining data into composites or including data from multiple years improves the reliability of ranking quality indicators for hospital care...
May 22, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29789008/pharmacological-effects-of-n-2-2-2-2-6-dichlorophenyl-amino-phenyl-acetyl-oxy-ethyl-hyaluronamide-diclofenac-etalhyaluronate-si-613-a-novel-sodium-hyaluronate-derivative-chemically-linked-with-diclofenac
#10
Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda, Kenji Miyamoto
BACKGROUND: Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with diclofenac (DF), diclofenac etalhyaluronate (SI-613), which is a potentially safer and more effective treatment for OA knee pain. In this study, we evaluated the pharmacological effects of SI-613 in experimental arthritis models. METHODS: We compared the analgesic and anti-inflammatory effects of intra-articularly administered SI-613, hyaluronic acid (HA), and of orally administered diclofenac sodium (DF-Na) in rat silver nitrate-induced arthritis model and rabbit antigen-induced arthritis model...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788992/comparing-case-control-study-for-treatment-of-proximal-tibia-fractures-with-a-complete-metaphyseal-component-in-two-centers-with-different-distinct-strategies-fixation-with-ilizarov-frame-or-locking-plates
#11
Haakon Berven, Michael Brix, Kaywan Izadpanah, Eva Johanna Kubosch, Hagen Schmal
BACKGROUND: The purpose of this study was to compare two methods of stabilization for proximal tibia fractures (AO 41) with a complete metaphyseal component, external fixation with the Ilizarov wire frame, and internal fixation with locking plates. METHODS: Patients from two level 1 trauma centers treated between 2009 and 2015 were included in a retrospective comparing cohort study. The first center stabilized the non-pathological, proximal tibia fractures exclusively with external fixation and the second with internal plating...
May 22, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29788950/construct-validity-and-reliability-of-the-finnish-version-of-the-knee-injury-and-osteoarthritis-outcome-score
#12
Juhani Multanen, Mikko Honkanen, Arja Häkkinen, Ilkka Kiviranta
BACKGROUND: The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a commonly used knee assessment and outcome tool in both clinical work and research. However, it has not been formally translated and validated in Finnish. The purpose of this study was to translate and culturally adapt the KOOS questionnaire into Finnish and to determine its validity and reliability among Finnish middle-aged patients with knee injuries. METHODS: KOOS was translated and culturally adapted from English into Finnish...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788949/range-of-motion-after-total-knee-arthroplasty-in-hemophilic-arthropathy
#13
Radovan Kubeš, Peter Salaj, Rastislav Hromádka, Josef Včelák, Aleš Antonín Kuběna, Monika Frydrychová, Štěpán Magerský, Michal Burian, Martin Ošťádal, Jan Vaculik
BACKGROUND: Outcomes of total knee replacement in cases of hemophilic patients are worse than in patients who undergo operations due to osteoarthritis. Previous publications have reported varying rates of complications in hemophilic patients, such as infection and an unsatisfactory range of motion, which have influenced the survival of prostheses. Our retrospective study evaluated the data of hemophilic patients regarding changes in the development of the range of motion. METHODS: The data and clinical outcomes of 72 total knee replacements in 45 patients with hemophilia types A and B were reviewed retrospectively...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788284/military-service-and-decision-quality-in-the-management-of-knee-osteoarthritis
#14
Eric R Henderson, Alexander J Titus, Benjamin J Keeney, Philip P Goodney, Jon D Lurie, Said A Ibrahim
Background: Decision quality measures the degree to which care decisions are knowledge-based and value-aligned. Because military service emphasizes hierarchy, command, and mandates some healthcare decisions, military service may attenuate patient autonomy in healthcare decisions and lower decision quality. VA is the nation's largest provider of orthopedic care. We compared decision quality in a sample of VA and non-VA patients seeking care for knee osteoarthritis. Methods: Our study sample consisted of patients newly referred to our orthopedic clinic for the management of knee osteoarthritis...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29788253/effectiveness-of-a-blended-physical-therapist-intervention-in-people-with-hip-osteoarthritis-knee-osteoarthritis-or-both-a-cluster-randomized-controlled-trial
#15
Corelien J J Kloek, Daniël Bossen, Peter M Spreeuwenberg, Joost Dekker, Dinny H de Bakker, Cindy Veenhof
Background: Integrating physical therapy sessions and an online application (e-Exercise) might support people with hip osteoarthritis (OA), knee OA, or both (hip/knee OA) in taking an active role in the management of their chronic condition and may reduce the number of physical therapy sessions. Objective: The objective of this study was to investigate the short- and long-term effectiveness of e-Exercise compared to usual physical therapy in people with hip/knee OA...
May 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29785450/light-intensity-physical-activity-increases-and-sedentary-behavior-decreases-following-total-knee-arthroplasty-in-patients-with-osteoarthritis
#16
Emmanuel Frimpong, Joanne A McVeigh, Dick van der Jagt, Lipalo Mokete, Yusuf S Kaoje, Mohammed Tikly, Rebecca M Meiring
PURPOSE: To describe objectively measured changes in the volume and pattern of physical activity and sedentary behavior in patients undergoing total knee arthroplasty for osteoarthritis. METHODS: Physical activity and sedentary behavior were measured in patients (13 males, 76 females) with a mean age of 64 years (range 55-80) and end-stage osteoarthritis of the knee, using an accelerometer (ActiGraph GT3X+) for seven consecutive days (24 h/day) prior to, 6 weeks and 6 months after total knee arthroplasty...
May 21, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29785447/posterior-cortical-breakage-leads-to-posterior-tibial-slope-change-in-lateral-hinge-fracture-following-opening-wedge-high-tibial-osteotomy
#17
Sung-Sahn Lee, Kyung-Wook Nha, Dae-Hee Lee
PURPOSE: This study was designed to analyze the relationship between changes in posterior tibial slope and the absence or presence of lateral hinge fracture, diagnosed in the sagittal and axial planes, as well as the coronal plane, by computed tomography (CT) following opening wedge high tibial osteotomy (HTO). METHODS: This study involved 55 patients (55 knees) undergoing opening wedge HTO for primary medial osteoarthritis. Lateral hinge fractures were evaluated on CT scans according to the Takeuchi classification and were also classified as subtypes A, B, and C, depending on anterior, posterior, and both anterior and posterior cortical disruptions, respectively, as determined by the sagittal and axial planes of CT scans which corresponded to the fracture line visible on coronal CT scans...
May 21, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29784003/bi-directional-regulation-of-cartilage-metabolism-by-inhibiting-bet-proteins-analysis-of-the-effect-of-i-bet151-on-human-chondrocytes-and-murine-joints
#18
Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Dongyang Chen, Zhihong Xu, Dongquan Shi, Jianxin Li, Huangxian Ju, Yi Cao, Minghao Zheng, Chao Jun Li, Xiang Gao, Huajian Teng, Qing Jiang
BACKGROUND: Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has been shown to exert an anti-inflammatory effect by repressing the BET protein-mediated expression of inflammatory genes. Our objective is to investigate the effect of I-BET151 on a surgical mouse model of osteoarthritis (OA) and human chondrocytes. METHODS: We first treated a surgical mouse model of OA with I-BET151 once per day and evaluated the knee joints at 6 and 8 weeks after treatment...
May 21, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29783271/mid-term-clinical-outcome-and-reconstruction-of-posterior-tibial-slope-after-uka
#19
Alois Franz, Christoph Kolja Boese, Andrej Matthies, Jörg Leffler, Christian Ries
Unicompartmental knee arthroplasty (UKA) has gained growing popularity over the last decades. The posterior tibial slope (PTS) has been shown to play a significant role for knee biomechanics and is thought to be crucial for clinical function of the UKA. We evaluated the clinical outcome at mid-term follow-up after UKA. Furthermore, the reconstruction of the individual PTS was analyzed. A total of 91 consecutive patients undergoing medial UKA for osteoarthritis were included. Patients were contacted by telephone for a survival analysis at a minimum of 30 months after surgery...
May 21, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29783048/effect-of-auriculotherapy-on-the-plasma-concentration-of-biomarkers-in-individuals-with-knee-osteoarthritis
#20
Rebeca Graça Costa-Cavalcanti, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Cristiane Ribeiro Kütter, Samuel Brandão-Sobrinho-Neto, Laisa Liane Paineiras-Domingos, Marcia Cristina Moura-Fernandes, João Marcelo Castelpoggi da Costa, José Maurício de Morais Carmo, José Firmino Nogueira-Neto, Shyang Chang, Mario Bernardo-Filho
Knee osteoarthritis (KOA) is one of the most frequent non-communicable diseases with pain associated symptoms and affects the musculoskeletal system. Various forms of treatment can be indicated and non-pharmacological treatment is also an available option for the management of KOA individuals. For instance, auriculotherapy (AT) is one possible procedure associated with the Traditional Chinese Medicine for dealing with KOA. It is believed that the concentration of certain biomarkers could be altered in individuals with KOA after AT...
May 18, 2018: Journal of Acupuncture and Meridian Studies
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