Alberto J Espay, Fabrizio Stocchi, Rajesh Pahwa, Alberto Albanese, Aaron Ellenbogen, Joaquim J Ferreira, Nir Giladi, Tanya Gurevich, Sharon Hassin-Baer, Jorge Hernandez-Vara, Stuart H Isaacson, Karl Kieburtz, Peter A LeWitt, Lydia Lopez-Manzanares, C Warren Olanow, Werner Poewe, Harini Sarva, Tami Yardeni, Liat Adar, Laurence Salin, Nelson Lopes, Nissim Sasson, Ryan Case, Olivier Rascol
BACKGROUND: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-release levodopa-carbidopa for the treatment of motor fluctuations in people with Parkinson's disease...
March 15, 2024: Lancet Neurology