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https://www.readbyqxmd.com/read/28073810/cognitive-behavioural-therapy-for-non-motor-symptoms-of-parkinson-s-disease-a-clinical-review
#1
Ivan Koychev, David Okai
Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have a disproportionate impact on quality of life and carer burden. Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive-behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia...
January 10, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28073650/the-utilisation-of-one-district-hospital-emergency-department-by-people-with-parkinson-s-disease
#2
Marion Harris, Margaret Fry
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder in Australia and the economic burden is more than $8.3 billion a year and predicted to escalate. However, little is known of the trends and characteristics of people with Parkinson's disease presenting to emergency departments (ED). METHOD: The study design was a 12 month retrospective medical record audit. The study was conducted in one metropolitan 300 bed district hospital in an outer suburb of Sydney...
January 7, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28008361/fuzzy-logic-based-risk-of-fall-estimation-using-smartwatch-data-as-a-means-to-form-an-assistive-feedback-mechanism-in-everyday-living-activities
#3
Dimitrios E Iakovakis, Fotini A Papadopoulou, Leontios J Hadjileontiadis
This Letter aims to create a fuzzy logic-based assistive prevention tool for falls, based on accessible sensory technology, such as smartwatch, resulting in monitoring of the risk factors of falls caused by orthostatic hypotension (OH); a drop in systolic blood pressure (DSBP) >20 mmHg due to postural changes. Epidemiological studies have shown that OH is a high risk factor for falls and has a strong impact in quality of life (QoL) of the elderly's, especially for some cases such as Parkinsonians. Based on smartwatch data, it is explored here how statistical features of heart rate variability (HRV) can lead to DSBP prediction and estimation of the risk of fall...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28001292/predictors-for-unplanned-hospitalization-of-new-home-care-clients
#4
Jukka K Rönneikkö, Matti Mäkelä, Esa R Jämsen, Heini Huhtala, Harriet Finne-Soveri, Anja Noro, Jaakko N Valvanne
OBJECTIVES: To identify factors predicting unplanned hospitalization of new home care clients using the Resident Assessment Instrument for Home Care (RAI-HC). DESIGN: A register-based study based on RAI-HC assessments and nationwide hospital discharge records. SETTING: Municipal home care services in Finland. PARTICIPANTS: New Finnish home care clients aged 63 and older (N = 15,700). MEASUREMENTS: Information from home care clients' first RAI-HC assessment was connected to information regarding their first hospitalization over 1 year of follow-up...
December 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28000003/long-term-risk-of-falls-in-an-incident-parkinson-s-disease-cohort-the-norwegian-parkwest-study
#5
Ylva Hivand Hiorth, Guido Alves, Jan Petter Larsen, Jörn Schulz, Ole-Bjørn Tysnes, Kenn Freddy Pedersen
The objective of this study is to examine the frequency, development, concomitants, and risk factors of falls in a population-based incident Parkinson's disease (PD) cohort. One hundred eighty-one drug-naïve patients with incident PD and 173 normal controls recruited from the Norwegian ParkWest study were prospectively monitored over 7 years. Information on falls was obtained biannually from patients, and at baseline and after 1, 3, 5, and 7 years of follow-up in control subjects. Generalized estimating equation models for correlated data were applied to investigate concomitant features of falls and risk factors for incident falls during 7 years of follow-up in PD...
December 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27995109/chitosan-myristate-nanogel-as-an-artificial-chaperone-protects-neuroserpin-from-misfolding
#6
Habib Nazem, Afshin Mohsenifar, Sahar Majdi
BACKGROUND: Molecular chaperon-like activity for protein refolding was studied using nanogel chitosan-myristic acid (CMA) and the protein neuroserpin (NS), a member of the serine proteinase inhibitor superfamily (serpin). MATERIALS AND METHODS: Recombinant his-tag fusion NS was expressed in Escherichia coli. For confirmation of refolding of the purified NS, structural analysis was performed by circular dichroism and spectrofluorometric along with its inhibitory activity, which was assayed by single-chain tissue plasminogen activator...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27993586/imposed-faster-and-slower-walking-speeds-influence-gait-stability-differently-in-parkinson-fallers
#7
Michael H Cole, Matthew Sweeney, Zachary J Conway, Tim Blackmore, Peter A Silburn
OBJECTIVE: This cross-sectional study sought to evaluate the effect of imposed faster and slower walking speeds on postural stability in people with Parkinson's disease (PD). DESIGN: Cross-sectional cohort study; SETTING: General community PARTICIPANTS: 84 PD patients (51 with a falls history; 33 without) and 82 age-matched controls were invited to participate via neurology clinics and pre-existing databases. Of those contacted, 99 did not respond (PD=36; controls=63) and 27 were not interested (PD=18; controls=9)...
December 16, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27984031/polestriding-intervention-improves-gait-and-axial-symptoms-in-mild-to-moderate-parkinson-s-disease
#8
Narayanan Krishnamurthi, Holly Shill, Darolyn O'Donnell, Padma Mahant, Johan Samanta, Abraham Lieberman, James Abbas
OBJECTIVE: To evaluate the effects of 12-week polestriding intervention on gait and disease severity in people with mild to moderate Parkinson's disease DESIGN: A-B-A withdrawal study design SETTING: Outpatient movement disorder center and community facility. PARTICIPANTS: Individuals (9 females and 8 males; mean age: 63.7 ± 4.9 years; range 53 - 72 years) with mild to moderate PD according to UK brain bank criteria with Hoehn and Yahr (H&Y) score from 2.5 to 3...
October 27, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27977519/a-cross-sectional-analysis-of-the-characteristics-of-individuals-with-parkinson-disease-who-avoid-activities-and-participation-due-to-fear-of-falling
#9
Merrill R Landers, Morgan Lopker, Molly Newman, Russell Gourlie, Spencer Sorensen, Rithea Vong
BACKGROUND AND PURPOSE: Avoidance behavior can have deleterious consequences on health and quality of life for persons with Parkinson disease (PD); for this reason, it is important to identify potentially mitigable characteristics. We compared the characteristics of individuals with PD who exhibit fear of falling (FOF) avoidance behavior with those who do not. METHODS: Fifty-nine participants with PD were classified as avoiders (n = 27) or nonavoiders (n = 32) by using the Fear of Falling Avoidance Behavior Questionnaire and compared across 5 domains: demographic characteristics; PD-specific symptoms (subtype, Movement Disorder Society-Unified Parkinson's Disease Rating Scale [MDS-UPDRS], Hoehn and Yahr Scale, Parkinson's Disease Questionnaire-39 [PDQ-39]); balance and falls (fall history, Berg Balance Scale [BBS], Activities-Specific Balance Confidence [ABC] Scale, Impact of Events Scale, Consequences of Falling Questionnaire [CoFQ]); physical performance (30 Second Sit-to-Stand Test, Timed Up and Go Test, physical activity monitoring); and psychological factors (Zung Anxiety Scale, Beck Depression Inventory [BDI])...
January 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/27939113/effects-of-auditory-cues-on-gait-initiation-and-turning-in-patients-with-parkinson-s-disease
#10
J Gómez-González, P Martín-Casas, R Cano-de-la-Cuerda
OBJECTIVE: To review the available scientific evidence about the effectiveness of auditory cues during gait initiation and turning in patients with Parkinson's disease. METHODS: We conducted a literature search in the following databases: Brain, PubMed, Medline, CINAHL, Scopus, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Library Plus, CENTRAL, Trip Database, PEDro, DARE, OTseeker, and Google Scholar. We included all studies published between 2007 and 2016 and evaluating the influence of auditory cues on independent gait initiation and turning in patients with Parkinson's disease...
December 8, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27933155/a-quality-improvement-initiative-on-the-management-of-osteoporosis-in-older-people-with-parkinsonism
#11
Inderpal Singh, Rachel Fletcher, Linda Scanlon, Mandy Tyler, Shridhar Aithal
The risk of falls is higher in patients with people with Parkinsonism (PwP) compared to those without Parkinsonism, and leads to adverse outcomes including fragility fractures. Osteoporosis is under-recognised, and the prevalence of fragility fractures in not well studied. The primary aim of this project is for 100% of new patient referrals to, and 80% of follow up patients within the movement disorder (MD) service with osteoporosis to be treated in accordance with evidence based osteoporosis guidance. Routinely captured information regarding demographics and fragility fractures was retrospectively extracted from the clinical workstation, clinic letters, and clinical coding between July and November 2015...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27929574/should-respond-change-falls-prevention-in-parkinson-s-disease
#12
J L Taylor, D Sumakadas
No abstract text is available yet for this article.
June 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27913063/a-novel-approach-to-falls-classification-in-parkinson-s-disease-development-of-the-fall-related-activity-classification-frac
#13
Annie Ross, Alison J Yarnall, Lynn Rochester, Sue Lord
BACKGROUND: Falls are a major problem for people with Parkinson's disease (PD). Despite years of focused research knowledge of falls aetiology is poor. This may be partly due to classification approaches which conventionally report fall frequency. This nosology is blunt, and does not take into account causality or the circumstances in which the fall occurred. For example, it is likely that people who fall from a postural transition are phenotypically different to those who fall during high level activities...
September 3, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27911340/dementia-predictors-in-parkinson-disease-a-validation-study
#14
Julius Bm Anang, Takashi Nomura, Silvia Rios Romenets, Kenji Nakashima, Jean-Francois Gagnon, Ronald B Postuma
In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27893564/instrumented-test-of-sensory-integration-for-balance-a-validation-study
#15
Lynn Freeman, Geetanjali Gera, Fay B Horak, Mary T Blackinton, Mark Besch, Laurie King
BACKGROUND AND PURPOSE: Abnormal postural sway is associated with an increase in risk of falls but is difficult for clinicians to accurately quantify without access to laboratory equipment. Instrumenting clinical outcome measures using body-worn movement monitors is a low-cost alternative. This is the first study to compare the modified Clinical Test of Sensory Integration for Balance (i-mCTSIB) to the laboratory test of the Sensory Organization Test (SOT) with dynamic posturography in a group of participants with Parkinson's disease (PD) and subtle balance limitations...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27889925/deletion-of-the-vesicular-acetylcholine-transporter-from-pedunculopontine-laterodorsal-tegmental-neurons-modifies-gait
#16
Helena Janickova, Kaie Rosborough, Mohammed Al-Onaizi, Ornela Kljakic, Monica S Guzman, Robert Gros, Marco A M Prado, Vania F Prado
Postural instability and gait disturbances, common disabilities in the elderly and frequently present in Parkinson's disease (PD), have been suggested to be related to dysfunctional cholinergic signalling in the brainstem. We investigated how long-term loss of cholinergic signalling from mesopontine nuclei influence motor behaviours. We selectively eliminated the vesicular acetylcholine transporter (VAChT) in pedunculopontine and laterodorsal tegmental nuclei cholinergic neurons to generate mice with selective mesopontine cholinergic deficiency (VAChT(E)(n1-Cre-flox/flox) )...
November 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27887896/comorbid-parkinson-s-disease-falls-and-fractures-in-the-2010-national-emergency-department-sample
#17
Hind A Beydoun, May A Beydoun, Nishant K Mishra, Ola S Rostant, Alan B Zonderman, Shaker M Eid
INTRODUCTION: Parkinson's disease (PD) is a progressive, neurodegenerative disorder of multifactorial etiology affecting ∼1% of older adults. Research focused on linking PD to falls and bone fractures has been limited in Emergency Department (ED) settings, where most injuries are identified. We assessed whether injured U.S. ED admissions with PD diagnoses were more likely to exhibit comorbid fall- or non-fall related bone fractures and whether a PD diagnosis with a concomitant fall or bone fracture is linked to worse prognosis...
November 19, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27883986/a-model-of-free-living-gait-a-factor-analysis-in-parkinson-s-disease
#18
Rosie Morris, Aodhán Hickey, Silvia Del Din, Alan Godfrey, Sue Lord, Lynn Rochester
INTRODUCTION: Gait is a marker of global health, cognition and falls risk. Gait is complex, comprised of multiple characteristics sensitive to survival, age and pathology. Due to covariance amongst characteristics, conceptual gait models have been established to reduce redundancy and aid interpretation. Previous models have been derived from laboratory gait assessments which are costly in equipment and time. Body-worn monitors (BWM) allow for free-living, low-cost and continuous gait measurement and produce similar covariant gait characteristics...
November 16, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27876560/subcutaneous-rotenone-rat-model-of-parkinson-s-disease-dose-exploration-study
#19
Zhen-Nian Zhang, Jing-Si Zhang, Jun Xiang, Zhong-Hai Yu, Wen Zhang, Min Cai, Xiang-Ting Li, Ting Wu, Wen-Wei Li, Ding-Fang Cai
Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this technique objectively. The aim of the present study was to identify the optimum dose of subcutaneous rotenone for establishing a model of PD. We injected male Wistar rats subcutaneously with one of three doses of rotenone (1...
January 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27866086/the-role-of-postural-instability-gait-difficulty-and-fear-of-falling-in-predicting-falls-in-non-demented-older-adults
#20
Gilles Allali, Emmeline I Ayers, Roee Holtzer, Joe Verghese
INTRODUCTION: Postural instability/gait difficulty (PIGD) and fear of falling (FoF) frequently co-exist, but their individual predictive values for falls have not been compared in aging. This study aims to determine both independent and combined effect of PIGD and FoF to falls in older adults without dementia. METHODS: PIGD and other extrapyramidal signs were systematically assessed in 449 community-dwelling participants without Parkinson's disease (76.48±6.61 ys; 56...
March 2017: Archives of Gerontology and Geriatrics
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