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https://www.readbyqxmd.com/read/28330963/decrease-in-a%C3%AE-42-predicts-dopa-resistant-gait-progression-in-early-parkinson-disease
#1
Lynn Rochester, Brook Galna, Sue Lord, Alison J Yarnall, Rosie Morris, Gordon Duncan, Tien K Khoo, Brit Mollenhauer, David J Burn
OBJECTIVE: This prospective observational study investigates the role of CSF biomarkers in predicting progression of dopa-resistant gait impairments in Parkinson disease (PD) in the first 36 months from diagnosis. METHODS: Quantitative gait analysis was carried out longitudinally using an instrumented walkway (GAITRite) in 108 people with PD and 130 age-matched controls. A subgroup of 44 people with PD underwent lumbar puncture from which a battery of CSF biomarkers was measured: β-amyloid 1-42 and 1-40 (Aβ42 and Aβ40), total and phosphorylated tau protein (t-tau/p-tau181), and α-synuclein (αSyn)...
March 22, 2017: Neurology
https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#2
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28326165/neurochemical-and-motor-changes-in-mice-with-combined-mutations-linked-to-parkinson-s-disease
#3
Xiang Bai, Margaret Chia-Ying Wey, Paul Anthony Martinez, Chao Shi, Elizabeth Fernandez, Randy Strong
Considerable evidence suggests that oxidative stress plays a role in the pathogenesis of Parkinson's disease (PD), the most prevalent neurodegenerative movement disorder. Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. To determine whether deficiency in these two genes contributes to the pathogenesis of PD, mice were generated with homozygous null mutations of both Aldh1a1 (the murine homolog of ALDH1) and Gpx1 genes [knockout (KO) mice]...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/28279773/deep-brain-stimulation-of-pedunculopontine-nucleus-for-postural-instability-and-gait-disorder-after-parkinson-s-disease-a-meta-analysis-of-individual-patient-data
#4
Jia-Wei Wang, Yu-Qing Zhang, Xiao-Hua Zhang, Yun-Peng Wang, Ji-Ping Li, Yong-Jie Li
BACKGROUND: Postural instability and gait disorder(PIGD) in Parkinson's disease (PD) have been a great challenge in the clinical practice since PIGD is closely linked to major morbidity and mortality in PD. Pedunculopontine nucleus (PPN) has been considered as a potential promising target for deep brain stimulation (DBS) in the treatment of PIGD. Thus, this meta-analysis of individual patient data (IPD) was performed to assess the effects of PPN DBS on PIGD in PD patients and explore the factors predicting good outcome...
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28275046/self-reported-sleep-disturbance-and-incidence-of-dementia-in-ageing-men
#5
Maria K Luojus, Soili M Lehto, Tommi Tolmunen, Anna-Katharine Brem, Eija Lönnroos, Jussi Kauhanen
BACKGROUND: Sleep disturbance is suggested to contribute to the development of dementia. However, prospective longitudinal data from middle-aged populations are scarce. METHODS: We investigated a population-based sample of 2386 men aged 42-62 years at baseline during 1984-1989. Participants having a history of mental illnesses, psychiatric medication, Parkinson's disease or dementia within 2 years after baseline (n=296) were excluded. Difficulty falling asleep or maintaining sleep, sleep duration and daytime tiredness were enquired...
April 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28268634/detection-of-gait-initiation-failure-in-parkinson-s-disease-patients-using-eeg-signals
#6
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Gait Initiation Failure (GIF) is one of the most disabling gait disturbances seen in advanced Parkinson's disease (PD). Gait Initiation is a complex motor task that requires motor and cognitive processing to enable the correct selection, timing and scaling of movement. Failure to initiate the first step often precipitates falls and leads to significant morbidity. However, the brain mechanisms underlying GIF remain unknown. This study utilized an ambulatory electroencephalography (EEG) technique to investigate the brain dynamic changes underlying GIF and aims to detect the occurrence of GIF in four PD patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268412/towards-holistic-free-living-assessment-in-parkinson-s-disease-unification-of-gait-and-fall-algorithms-with-a-single-accelerometer
#7
Alan Godfrey, Alan Bourke, Silvia Del Din, Rosie Morris, Aodhan Hickey, Jorunn L Helbostad, Lynn Rochester
Technological developments have seen the miniaturization of sensors, small enough to be embedded in wearable devices facilitating unobtrusive and longitudinal monitoring in free-living environments. Concurrently, the advances in algorithms have been ad-hoc and fragmented. To advance the mainstream use of wearable technology and improved functionality of algorithms all methodologies must be unified and robustly tested within controlled and free-living conditions. Here we present and unify a (i) gait segmentation and analysis algorithm and (ii) a fall detection algorithm...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268275/reinforcement-learning-for-stabilizing-an-inverted-pendulum-naturally-leads-to-intermittent-feedback-control-as-in-human-quiet-standing
#8
Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
Intermittent feedback control for stabilizing human upright stance is a promising strategy, alternative to the standard time-continuous stiffness control. Here we show that such an intermittent controller can be established naturally through reinforcement learning. To this end, we used a single inverted pendulum model of the upright posture and a very simple reward function that gives a certain amount of punishments when the inverted pendulum falls or changes its position in the state space. We found that the acquired feedback controller exhibits hallmarks of the intermittent feedback control strategy, namely the action of the feedback controller is switched-off intermittently when the state of the pendulum is located near the stable manifold of the unstable saddle-type upright equilibrium of the inverted pendulum with no active control: this action provides an opportunity to exploit transiently converging dynamics toward the unstable upright position with no help of the active feedback control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267762/impaired-perception-of-surface-tilt-in-progressive-supranuclear-palsy
#9
Marian L Dale, Fay B Horak, W Geoffrey Wright, Bernadette M Schoneburg, John G Nutt, Martina Mancini
INTRODUCTION: Progressive supranuclear palsy (PSP) is characterized by early postural instability and backward falls. The mechanisms underlying backward postural instability in PSP are not understood. The aim of this study was to test the hypothesis that postural instability in PSP is a result of dysfunction in the perception of postural verticality. METHODS: We gathered posturography data on 12 subjects with PSP to compare with 12 subjects with idiopathic Parkinson's Disease (PD) and 12 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28264087/precipitous-deterioration-of-motor-function-cognition-and-behavior
#10
Mireya Fernández-Fournier, David C Perry, Maria Carmela Tartaglia, Mary de May, Adam Boxer, Giovanni Coppola, Chadwick W Christine, Eric J Huang, William W Seeley, Bruce L Miller, Steven J DeArmond, Lea T Grinberg, Michael D Geschwind
A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications...
March 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28263926/dopamine-depletion-impairs-gait-automaticity-by-altering-cortico-striatal-and-cerebellar-processing-in-parkinson-s-disease
#11
Moran Gilat, Peter T Bell, Kaylena A Ehgoetz Martens, Matthew J Georgiades, Julie M Hall, Courtney C Walton, Simon J G Lewis, James M Shine
Impairments in motor automaticity cause patients with Parkinson's disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson's disease. This impedes clinical management and is in great part due to mobility restrictions that accompany the neuroimaging of gait...
March 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28263256/factors-associated-with-ambulatory-activity-in-de-novo-parkinson-disease
#12
Cory Christiansen, Charity Moore, Margaret Schenkman, Benzi Kluger, Wendy Kohrt, Anthony Delitto, Brian Berman, Deborah Hall, Deborah Josbeno, Cynthia Poon, Julie Robichaud, Toby Wellington, Samay Jain, Cynthia Comella, Daniel Corcos, Ed Melanson
BACKGROUND AND PURPOSE: Objective ambulatory activity during daily living has not been characterized for people with Parkinson disease prior to initiation of dopaminergic medication. Our goal was to characterize ambulatory activity based on average daily step count and examine determinants of step count in nonexercising people with de novo Parkinson disease. METHODS: We analyzed baseline data from a randomized controlled trial, which excluded people performing regular endurance exercise...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28258925/parkinsonian-gait-improves-with-bilateral-subthalamic-nucleus-deep-brain-stimulation-during-cognitive-multi-tasking
#13
Gaurav Chenji, Melissa L Wright, Kelvin L Chou, Rachael D Seidler, Parag G Patil
BACKGROUND: Gait impairment in Parkinson's disease reduces mobility and increases fall risk, particularly during cognitive multi-tasking. Studies suggest that bilateral subthalamic deep brain stimulation, a common surgical therapy, degrades motor performance under cognitive dual-task conditions, compared to unilateral stimulation. OBJECTIVE: To measure the impact of bilateral versus unilateral subthalamic deep brain stimulation on walking kinematics with and without cognitive dual-tasking...
February 24, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28258036/use-of-ace-inhibitors-and-falls-in-patients-with-parkinson-s-disease
#14
Alice Laudisio, Maria Rita Lo Monaco, Maria Caterina Silveri, Anna Rita Bentivoglio, Davide L Vetrano, Maria Stella Pisciotta, Vincenzo Brandi, Roberto Bernabei, Giuseppe Zuccalà
Falls represent a major concern in patients with Parkinson's disease (PD); however, currently acknowledged treatments for PD are not effective in reducing the risk of falling. The aim was to assess the association of use of ACE-inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) with falls among patients with PD. We analysed data of 194 elderly with PD attending a geriatric Day Hospital. Self-reported history of falls that occurred over the last year, as well as use of drugs, including ACEIs and angiotensin II receptor blockers (ARBs) were recorded...
February 22, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28253409/enhancing-care-for-hospitalized-patients-with-parkinson-s-disease-development-of-a-formal-educational-program-for-nursing-staff
#15
Mary C DiBartolo
Although not generally a primary admission diagnosis, Parkinson's disease (PD) can be a significant comorbidity during hospitalization. Hospitalized individuals with PD can experience a variety of complications, such as confusion, pneumonia, and urinary infections. More than 20% of patients experience deterioration in symptoms and hospital stays are extended by an average of 4 days. Late, omitted, or inappropriate medications are frequent culprits leading to serious consequences, including falls and aspiration...
March 2, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28251464/serum-uric-acid-levels-and-freezing-of-gait-in-parkinson-s-disease
#16
Ruwei Ou, Bei Cao, Qianqian Wei, Yanbing Hou, Yaqian Xu, Wei Song, Bi Zhao, Huifang Shang
Uric acid (UA) is a natural antioxidant and iron scavenger in the human body, which has been hypothesized to exert an anti-oxidative effect in Parkinson's disease (PD). This study aimed to investigate the relationship between serum UA levels and freezing of gait (FOG) in PD. A total of 321 Chinese PD patients with fasting serum UA evaluated were included in the cross-sectional study. Demographics, clinical features, and therapeutic regimen were collected. The Unified PD Rating Scale (UPDRS) III and Hoehn and Yahr (H and Y) stage were used to evaluate the severity of disease, and the Frontal Assessment Battery (FAB) and Montreal Cognitive Assessment (MoCA) scales were used to assess the cognitive function...
March 1, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28251357/freezing-of-gait-and-fall-detection-in-parkinson-s-disease-using-wearable-sensors-a-systematic-review
#17
REVIEW
Ana Lígia Silva de Lima, Luc J W Evers, Tim Hahn, Lauren Bataille, Jamie L Hamilton, Max A Little, Yasuyuki Okuma, Bastiaan R Bloem, Marjan J Faber
Despite the large number of studies that have investigated the use of wearable sensors to detect gait disturbances such as Freezing of gait (FOG) and falls, there is little consensus regarding appropriate methodologies for how to optimally apply such devices. Here, an overview of the use of wearable systems to assess FOG and falls in Parkinson's disease (PD) and validation performance is presented. A systematic search in the PubMed and Web of Science databases was performed using a group of concept key words...
March 1, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28250027/predictors-of-survival-in-progressive-supranuclear-palsy-and-multiple-system-atrophy-a-systematic-review-and-meta-analysis
#18
Stella Andrea Glasmacher, Peter Nigel Leigh, Romi Anirban Saha
OBJECTIVE: To undertake a systematic review and meta-analysis of studies that investigated prognostic factors and survival in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). METHODS: Publications of at least 10 patients with a likely or confirmed diagnosis of PSP or MSA were eligible for inclusion. Methodological quality was rated using a modified version of the Quality in Prognostic Studies tool. For frequently examined prognostic factors, HRs derived by univariate and multivariate analysis were pooled in separate subgroups; other results were synthesised narratively and HRs could not be reported here...
March 1, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28244545/the-effect-of-balance-training-on-postural-control-in-patients-with-parkinson-s-disease-using-a-virtual-rehabilitation-system
#19
Sergio Albiol-Pérez, José-Antonio Gil-Gómez, María-Teresa Muñoz-Tomás, Hermenegildo Gil-Gómez, Raquel Vial-Escolano, José-Antonio Lozano-Quilis
OBJECTIVES: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor clinical alterations among others. Postural problems have serious consequences for patients, not only limiting their daily life but also increasing some risks, like the risk of fall. Inadequate postural control and postural instability is a major problem in PD patients. A Virtual Motor Rehabilitation System (VMR) has been tested in patients with PD in the intervention period. Our purpose was to analyze the evolution of the spatial postural control during the intervention period, to see if there are any changes caused precisely by this intervention...
February 28, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28241159/timed-light-therapy-for-sleep-and-daytime-sleepiness-associated-with-parkinson-disease-a-randomized-clinical-trial
#20
Aleksandar Videnovic, Elizabeth B Klerman, Wei Wang, Angelica Marconi, Teresa Kuhta, Phyllis C Zee
Importance: Impaired sleep and alertness are some of the most common nonmotor manifestations of Parkinson disease (PD) and currently have only limited treatment options. Light therapy (LT), a widely available treatment modality in sleep medicine, has not been systematically studied in the PD population. Objective: To determine the safety and efficacy of LT on excessive daytime sleepiness (EDS) associated with PD. Design, Settings, and Participants: This randomized, placebo-controlled, clinical intervention study was set in PD centers at Northwestern University and Rush University...
February 20, 2017: JAMA Neurology
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