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https://www.readbyqxmd.com/read/28239501/consensus-on-the-definition-of-advanced-parkinson-s-disease-a-neurologists-based-delphi-study-cepa-study
#1
Maria-Rosario Luquin, Jaime Kulisevsky, Pablo Martinez-Martin, Pablo Mir, Eduardo S Tolosa
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28235814/differentiating-cognitive-impairment-due-to-corticobasal-degeneration-and-alzheimer-disease
#2
Gregory S Day, Tae Sung Lim, Jason Hassenstab, Alison M Goate, Elizabeth A Grant, Catherine M Roe, Nigel J Cairns, John C Morris
OBJECTIVE: To identify clinical features that reliably differentiate individuals with cognitive impairment due to corticobasal degeneration (CBD) and Alzheimer disease (AD). METHODS: Clinical features were compared between individuals with autopsy-proven CBD (n = 17) and AD (n = 16). All individuals presented with prominent cognitive complaints and were evaluated annually with semistructured interviews, detailed neurologic examinations, and neuropsychological testing...
February 24, 2017: Neurology
https://www.readbyqxmd.com/read/28226814/detection-of-gait-initiation-failure-in-parkinson-s-disease-patients-using-eeg-signals
#3
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen, Nghia Nguyen, A M Ardi Handojoseno, Moran Gilat, Hung T Nguyen, Yvonne Tran, Simon J G Lewis, Quynh Tran Ly, Rifai Chai
Gait Initiation Failure (GIF) is one of the most disabling gait disturbances seen in advanced Parkinson's disease (PD). Gait Initiation is a complex motor task that requires motor and cognitive processing to enable the correct selection, timing and scaling of movement. Failure to initiate the first step often precipitates falls and leads to significant morbidity. However, the brain mechanisms underlying GIF remain unknown. This study utilized an ambulatory electroencephalography (EEG) technique to investigate the brain dynamic changes underlying GIF and aims to detect the occurrence of GIF in four PD patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226582/towards-holistic-free-living-assessment-in-parkinson-s-disease-unification-of-gait-and-fall-algorithms-with-a-single-accelerometer
#4
Alan Godfrey, Alan Bourke, Silvia Del Din, Rosie Morris, Aodhan Hickey, Jorunn L Helbostad, Lynn Rochester, Alan Godfrey, Alan Bourke, Silvia Del Din, Rosie Morris, Aodhan Hickey, Jorunn L Helbostad, Lynn Rochester, Silvia Del Din, Rosie Morris, Alan Godfrey, Lynn Rochester, Jorunn L Helbostad, Aodhan Hickey, Alan Bourke
Technological developments have seen the miniaturization of sensors, small enough to be embedded in wearable devices facilitating unobtrusive and longitudinal monitoring in free-living environments. Concurrently, the advances in algorithms have been ad-hoc and fragmented. To advance the mainstream use of wearable technology and improved functionality of algorithms all methodologies must be unified and robustly tested within controlled and free-living conditions. Here we present and unify a (i) gait segmentation and analysis algorithm and (ii) a fall detection algorithm...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226432/reinforcement-learning-for-stabilizing-an-inverted-pendulum-naturally-leads-to-intermittent-feedback-control-as-in-human-quiet-standing
#5
Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura, Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura, Ken Kiyono, Pietro Morasso, Kenjiro Michimoto, Yasushi Kobayashi, Yasuyuki Suzuki, Taishin Nomura
Intermittent feedback control for stabilizing human upright stance is a promising strategy, alternative to the standard time-continuous stiffness control. Here we show that such an intermittent controller can be established naturally through reinforcement learning. To this end, we used a single inverted pendulum model of the upright posture and a very simple reward function that gives a certain amount of punishments when the inverted pendulum falls or changes its position in the state space. We found that the acquired feedback controller exhibits hallmarks of the intermittent feedback control strategy, namely the action of the feedback controller is switched-off intermittently when the state of the pendulum is located near the stable manifold of the unstable saddle-type upright equilibrium of the inverted pendulum with no active control: this action provides an opportunity to exploit transiently converging dynamics toward the unstable upright position with no help of the active feedback control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222651/levodopa-placebo-and-rotigotine-change-biomarker-levels-for-oxidative-stress
#6
Siegfried Muhlack, Manuel Kinkel, Lennard Herrman, Thomas Müller
INTRODUCTION: Homocysteine increase and glutathione derivative cysteinyl-glycine fall are indirect biomarkers for oxidative stress, for instance due to dopamine D1 receptor stimulation. OBJECTIVES: To investigate the influence of the D1 receptor agonists levodopa and rotigotine compared with placebo on homocysteine and cysteinyl-glycine in plasma of patients with Parkinson's disease. METHODS: Patients received 100 mg levodopa, 4 mg rotigotine or placebo...
February 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28222536/predictors-of-recurrent-falls-in-people-with%C3%A2-parkinson-s-disease-and-proposal-for%C3%A2-a%C3%A2-predictive-tool
#7
Lorena R S Almeida, Guilherme T Valenca, Nádja N Negreiros, Elen B Pinto, Jamary Oliveira-Filho
BACKGROUND: Falls are a debilitating problem for people with Parkinson's disease (PD). OBJECTIVES: To compare clinical and functional characteristics of non-fallers, single and recurrent fallers (≥2 falls); to determine predictors of time to second fall; and to develop a predictive tool for identifying people with PD at different categories of falls risk. METHODS: Participants (n = 229) were assessed by disease-specific, self-report and balance measures and followed up for 12 months...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28220396/evaluation-of-the-turning-characteristics-according-to-the-severity-of-parkinson-disease-during-the-timed-up-and-go-test
#8
Minji Son, Changhong Youm, Sangmyung Cheon, Jaewoo Kim, Meounggon Lee, Youkyung Kim, Jinhee Kim, Hyeryun Sung
BACKGROUND: Patients with Parkinson disease (PD) experience problems such as falls and freezing of gait during walking and turning in daily activities. However, few studies have examined the relationship between simultaneous turning tasks and the severity of PD. AIM: To investigate turning characteristics in patients with PD using three-dimensional (3D) analysis during the timed up and go (TUG) test. METHODS: Thirty individuals performed the TUG test under 3D motion analysis: 10 patients with Hoehn and Yahr (H&Y) stages 2...
February 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28211826/axial-rigidity-is-related-to-the-risk-of-falls-in%C3%A2-patients-with-parkinson-s-disease
#9
Roberto Cano-de-la-Cuerda, Lydia Vela-Desojo, Juan Carlos Miangolarra-Page, Yolanda Macías-Maías
BACKGROUND: Rigidity is a cardinal symptom of Parkinson's disease (PD) and is often clinically assessed by passively flexing and extending a patient's limb. Objective measurements had been employed to examine rigidity in PD subjects, including wrist, elbow or knee. OBJECTIVE: This study aimed to investigate the relationship between an objective measurement of trunk rigidity and risk of falls in patients with mild to moderate PD. METHODS: An isokinetic dynamometer Biodex System 3 was employed to assess trunk rigidity in 36 patients with mild to moderate PD at a University Department in a cross-sectional study...
February 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28186875/freezing-of-gait-detection-in-parkinson-s-disease-a-subject-independent-detector-using-anomaly-scores
#10
Thuy T Pham, Steven T Moore, Simon J G Lewis, Diep N Nguyen, Eryk Dutkiewicz, Andrew J Fuglevand, Alistair L McEwan, Philip H W Leong
Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients' self-report diaries and experts' manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this work, we aim to develop an automated FoG detector for subject-independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events...
February 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28185542/analysis-of-amplicon-based-ngs-data-from-neurological-disease-gene-panels-a-new-method-for-allele-drop-out-management
#11
Susanna Zucca, Margherita Villaraggia, Stella Gagliardi, Gaetano Salvatore Grieco, Marialuisa Valente, Cristina Cereda, Paolo Magni
BACKGROUND: Amplicon-based targeted resequencing is a commonly adopted solution for next-generation sequencing applications focused on specific genomic regions. The reliability of such approaches rests on the high specificity and deep coverage, although sequencing artifacts attributable to PCR-like amplification can be encountered. Between these artifacts, allele drop-out, which is the preferential amplification of one allele, causes an artificial increase in homozygosity when heterozygous mutations fall on a primer pairing region...
November 8, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28182156/how-do-demographic-transitions-and-public-health-policies-affect-patients-with-parkinson-s-disease-in-brazil
#12
REVIEW
Tânia M Bovolenta, Andre C Felicio
Brazil is currently experiencing a significant demographic transition characterized by a decrease in fertility rates and an exponential increase in the number of elderly citizens, which presents a special challenge for the health care professionals. More than other portions of the population, the elderly are most commonly affected by chronic diseases such as Parkinson's disease. Policymakers contend that Brazil is reasonably well-prepared regarding elderly health care, with policies that aim to ensure the quality of life and the well-being of this portion of the population...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28167197/influence-of-treadmill-gait-training-with-additional-load-on-motor-function-postural-instability-and-history-of-falls-for-individuals-with-parkinson-s-disease-a-randomized-clinical-trial
#13
Larissa Coutinho de Lucena Trigueiro, Gabriela Lopes Gama, Tatiana Souza Ribeiro, Louise Gabriella Lopes de Macedo Ferreira, Élida Rayanne Viana Pinheiro Galvão, Emília Márcia Gomes de Souza E Silva, Clécio de Oliveira Godeiro Júnior, Ana Raquel Rodrigues Lindquist
BACKGROUND: Evaluate the effects of additional load (5% and 10% of body weight) with treadmill gait training on the motor aspects in Parkinson's disease (PD). METHODS: Randomized controlled single-blind trial with 30 individuals with PD. The volunteers were divided into three groups (treadmill with 0%, 5% or 10% load), where Unified Parkinson's Disease Rating Scale was applied. Treadmill gait training was conducted over 4 consecutive weeks, with three weekly sessions of 30 min each...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28167167/nintendo-wii-fit-for-balance-rehabilitation-in-patients-with-parkinson-s-disease-a-comparative-study
#14
Stefano Negrini, Luciano Bissolotti, Alessandro Ferraris, Fulvia Noro, Mark D Bishop, Jorge Hugo Villafañe
BACKGROUND: Impaired postural stability places individuals with Parkinson's disease (PD) at an increased risk for falls. OBJECTIVE: We evaluated the effectiveness of 10 vs. 15 sessions of Nintendo Wii Fit for balance recovery for outpatients PD. METHODS: Twenty-seven patients, 48.1% female (66 ± 8 years), with PD. Patients with PD were consecutively assigned to one of two groups receiving either 10 or 15 sessions (low dose or high dose group, respectively) with Nintendo Wii Fit in recovering balancing ability...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28158197/rehabilitation-in-progressive-supranuclear-palsy-effectiveness-of-two-multidisciplinary-treatments
#15
Ilaria Clerici, Davide Ferrazzoli, Roberto Maestri, Fabiola Bossio, Ilaria Zivi, Margherita Canesi, Gianni Pezzoli, Giuseppe Frazzitta
BACKGROUND: to date, there are no medical or surgical treatments for progressive supranuclear palsy (PSP). It is possible to speculate that patients with PSP could benefit from rehabilitative treatments designed for Parkinson's disease, including the use of robot-assisted walking training. OBJECTIVE: to evaluate whether the use of the robotic device Lokomat® is superior in PSP patients to the use of treadmill with visual cues and auditory feedbacks (treadmill-plus) in the context of an aerobic, multidisciplinary, intensive, motor-cognitive and goal-based rehabilitation treatment (MIRT) conceived for Parkinsonian patients...
2017: PloS One
https://www.readbyqxmd.com/read/28151878/a-training-approach-to-improve-stepping-automaticity-while-dual-tasking-in-parkinson-s-disease-a-prospective-pilot-study
#16
Taylor Chomiak, Alexander Watts, Nicole Meyer, Fernando V Pereira, Bin Hu
BACKGROUND: Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life. This study aimed to test the feasibility and potential efficacy of a wearable sensor-enabled technological platform designed for an in-home music-contingent stepping-in-place (SIP) training program to improve step automaticity during dual-tasking (DT). METHODS: This was a 4-week prospective intervention pilot study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28126506/-other-causes-of-parkinsonism
#17
Christine Tranchant
Numerous causes may induce parkinsonism, and in case of Parkinsonism, l-dopa resistance, associated neurological signs, early falls, early dysautonomia or early cognitive disorders are the main red flags which should lead to exclude Parkinson's disease. Drug-induced parkinsonism and in young people, Wilson disease, should always be searched. Lower limbs parkinsonism is often due to vascular lesions. Multiple systemic atrophy, supranuclear palsy, Lewy body disease and the rarer corticobasal degeneration, each have specific clinical signs...
January 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28125950/fall-related-healthcare-use-and-costs-in-neurogenic-orthostatic-hypotension-with-parkinson-s-disease
#18
Clement François, Italo Biaggioni, Cyndya Shibao, Augustina Ogbonnaya, Huai-Che Shih, Eileen Farrelly, Adam Ziemann, Amy Duhig
AIMS: To compare patient characteristics, rates, and costs of medically attended falls among patients with Parkinson's disease (PD) and probable PD plus neurogenic orthostatic hypotension (PD + nOH). MATERIALS AND METHODS: MarketScan Commercial and Medicare Supplemental databases (January 1, 2009-December 31, 2013) were used to identify PD and probable PD + nOH patients. The first medical or prescription claim suggesting these diagnoses served as the index date...
February 6, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28117538/fall-related-hospitalization-in-people-with-parkinson-s-disease
#19
S S Paul, L Harvey, C G Canning, S Boufous, S R Lord, J C T Close, C Sherrington
BACKGROUND AND PURPOSE: Falls are common in people with Parkinson's disease (PD) but few data exist on fall-related hospitalizations in this group. This population-based study compared fall-related hospital admissions, injury rates and consequences in people with and without PD, and determined whether PD was an independent predictor of fall-related hospital length of stay. METHODS: This was a retrospective study using probabilistic linkage of hospital data in people aged ≥65 years hospitalized for a fall between 1 July 2005 and 31 December 2013 in New South Wales, Australia...
January 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28096960/estrogen-agonist-genistein-differentially-influences-the-cognitive-and-motor-disorders-in-an-ovariectomized-animal-model-of-parkinsonism
#20
Elaheh Arbabi, Gholamali Hamidi, Sayyed Alireza Talaei, Mahmoud Salami
OBJECTIVES: Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported that soy genistein, an estrogen agonist phytoestrogen, display neuroprotective effects against neuronal death. In this study we evaluated the effect of genistein in animal models of Parkinsonism (P) and Parkinsonism + ovariectomized (OP)...
December 2016: Iranian Journal of Basic Medical Sciences
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