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https://www.readbyqxmd.com/read/28212467/comparison-of-6-mercaptopurine-with-6-thioguanine-for-the-analysis-of-thiopurine-s-methyltransferase-activity-in-human-erythrocyte-by-lc-ms-ms
#1
Shenghui Mei, Xindi Li, Xiaoqing Gong, Xiaoyi Zhang, Xingang Li, Li Yang, Leting Zhu, Heng Zhou, Yonghong Liu, Anna Zhou, Xinghu Zhang, Zhigang Zhao
Thiopurines (TPDs) are first-line drugs in treating neuromyelitis optica spectrum disorders (NMOSD). Thiopurine S-methyltransferase activity (TPMT), a major determinant of TPDs toxicity, was suggested to be evaluated before TPDs treatment by using 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrate. However, the equivalent of the two substrates in TPMT activity evaluation was unknown, and alternative substrate was required in TPMT activity evaluation in patients who were already taking 6-MP or 6-TG...
February 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28211629/editorial-can-we-get-more-clinical-benefit-from-thiopurine-metabolite-testing
#2
EDITORIAL
A G Fraser
No abstract text is available yet for this article.
March 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28211625/editorial-can-we-get-more-clinical-benefit-from-thiopurine-metabolite-testing-authors-reply
#3
EDITORIAL
D R Wong, P M Hooymans
No abstract text is available yet for this article.
March 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28203101/prevalence-of-clinically-actionable-genotypes-and-medication-exposure-of-older-adults-in-the-community
#4
Nilofar Daneshi, Elizabeth Holliday, Stephen Hancock, Jennifer J Schneider, Rodney J Scott, John Attia, Elizabeth A Milward
This study analyzed clinically actionable pharmacogenotypes for clopidogrel, warfarin, statins, thiopurines, and tacrolimus using microarray data for 2121 participants (55-85 years) from the Australian Hunter Community Study (HCS). At least 74% of participants (95% confidence interval [CI]: 72%-76%) had strong level evidence for at least one medium- or high-risk actionable genotype that would trigger a change in standard therapy under current international recommendations. About 14% of these participants (95% CI: 12%-16%) were taking medication potentially affected by the genotype in question...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28193515/infliximab-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#5
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates and of malignancy and HLH in pediatric patients with IBD exposed to infliximab compared with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from 2007 through 30 June 2016...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28175252/n797-therapeutic-drug-monitoring-after-thiopurine-initiation-improves-drug-efficacy
#6
W Dijkstra-Heida, C Smids, M van Luin, G Huisman-de Waal, M de Leest, C Horjus Talabur Horje, J Wisse, P Wahab, M Groenen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175182/p729-increased-requirement-for-steroids-thiopurines-and-intestinal-surgery-in-crohn-s-patients-who-are-smokers-at-ibd-diagnosis-a-nationwide-population-based-study
#7
C Alexakis, S Saxena, V Chhaya, E Cecil, R Pollok
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175170/p649-does-switching-to-low-dose-thiopurine-and-allopurinol-prevent-ibd-patients-with-evidence-of-hypermethylation-on-standard-dose-thiopurines-from-developing-hepatotoxicity-and-drug-side-effects
#8
K Wade, H Johnson, K Slinger, C Hovell, S Weaver, S McLaughlin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175074/p428-optimizing-thiopurines-in-crohn-s-disease-low-dose-and-low-6-tgn-level-are-effective-for-maintenance-of-remission-in-asian-population
#9
R Mao, J Guo, S Ben Horin, M Chen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175071/p400-risk-adjusted-use-of-thiopurines-prevented-surgical-recurrence-in-patients-with-crohn-s-disease-after-intestinal-resection
#10
J Guo, R Mao, X Luo, S Ben Horin, M Chen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175051/p310-development-of-a-new-clinico-biological-score-associated-with-disease-activity-in-patients-with-inflammatory-bowel-disease-treated-with-thiopurine
#11
N Williet, S Nancey, A Boureille, R Altwegg, G Cadiot, M Nachury, D Laharie, J Filippi, M Sparrow, S Nahon, G Bouguen, P Aygalenq, S Viennot, G Bonnaud, M Dupin, N Boukhadra, E Del Tedesco, X Roblin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175008/p217-the-relationship-between-thiopurine-use-during-pregnancy-and-anemia-in-the-offspring-during-the-first-year-of-life
#12
A B-G Shitrit, S Granovsky-Grisaru, E Goldin, B Koslowsky
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174983/p096-combined-detection-variants-of-nudt15-could-highly-predict-thiopurine-induced-leukopenia-in-chinese-patients-with-inflammatory-bowel-disease-a-multi-center-analysis
#13
K Chao, X Zhu, Q Cao, H Yang, J Liang, L Lin, Z Huang, Y Zhang, Y Huang, Y Sun, X Xue, M Huang, P Hu, K Wu, P Lan, X Wang, J Qian, X Gao
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172964/p755-nudt15-polymorphism-is-associated-with-thiopurine-related-leukopenia-independently-of-6-thioguanine-nucleotide-levels-in-korean-paediatric-inflammatory-bowel-disease-patients
#14
B Kang, J Y Choi, K Lee, S-Y Lee, S H Ahn, H J Lee, Y H Choe
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172949/p396-long-term-efficacy-of-thiopurines-as-maintenance-treatment-in-130-patients-with-ulcerative-colitis
#15
C Lefevre, G Fotsing, M Wangermez, P Beau
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172900/p405-toxicity-of-thiopurines-in-patients-with-inflammatory-bowel-disease-inventory-and-predictive-factors
#16
A Labidi, M Serghini, N Ben Mustapha, M Fekih, J Boubaker, A Filali
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172859/p691-uv-exposure-and-skin-type-are-more-important-than-thiopurine-exposure-for-non-melanoma-skin-cancer-risk-in-ibd
#17
Y Wu, S Ghaly, S Kerr, K Krishnaprasad, R Prosser, B Jackson, K Hanigan, D Martins, R Mountifield, D Whiteman, P Bampton, R Gearry, G Radford-Smith, I C Lawrance
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172770/p764-response-to-thiopurines-is-independent-of-atg16l1-genotype
#18
B Verstockt, A T Matthias, K Strongili, I Cleynen, M Parkes
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172761/p479-shifting-the-shunters-in-a-paediatric-inflammatory-bowel-disease-population-thiopurine-dose-splitting-versus-allopurinol-and-thiopurine-co-therapy
#19
S Chadokufa, M Baycheva, T Sawney, N Acton, S Sider, N Shah, B Huggett, R Dziubak, F Kiparrissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172701/p386-a-target-6-thioguanine-nucleotide-%C3%A2-125-is-associated-with-a-higher-rate-and-longer-durability-of-response-in-infliximab-thiopurine-combination-therapy-a-retrospective-study-in-crohn-s-disease-patients
#20
R Luber, V Kariyawasam, L Dawson, S Munari, P Gibson, M Sparrow, M Ward
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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