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Non melanoma skin cancer

Delicia Avilla Barretto, Shyam Kumar Vootla
The present study reports the in vitro biological nature of the pigment produced by Staphylococcus gallinarum KX912244, isolated as the gut microflora bacterium of the insect Bombyx mori . The purified pigment was characterized as Staphyloxanthin based on bio-physical characterization techniques like Fourier transform infrared spectroscopy, high performance liquid chromatography, Proton nuclear magnetic resonance spectroscopy (1 H NMR), Liquid chromatography-Mass spectroscopy and Gas chromatography-Mass spectroscopy...
June 2018: Indian Journal of Microbiology
Toshiaki Saida
No abstract text is available yet for this article.
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Elizabet Saes da Silva, Roberto Tavares, Felipe da Silva Paulitsch, Linjie Zhang
The use of sunscreen is a key component of public health campaigns for skin cancer prevention, but epidemiological studies have raised doubts on its effectiveness in the general population. This systematic review and meta-analysis aimed to assess the association between risk of skin cancer and sunscreen use. We searched PubMed, BIREME and Google Scholar from inception to May 17, 2017, to identify observational studies and controlled trials. We used a random-effects model for conventional and cumulative meta-analyses...
April 5, 2018: European Journal of Dermatology: EJD
Carlos Anselmo Lima, Marcela Sampaio Lima, Angela Maria Da Silva, Marco Antonio Prado Nunes, Marcia Maria Macedo Lima, Marceli Oliveira Santos, Divaldo Lyra, Carlos Kleber Alves
Non-melanoma skin cancers have the highest incidence of all malignancies worldwide. However, cancer registries rarely include data on non-melanoma skin cancers because they tend to be under-reported. To determine incidence rates and changes over time for non-melanoma skin cancers in a mid-sized Brazilian population. We calculated age-standardized rates, adjusted to the world population using the direct method, from 1996-2012 in the Aracaju Cancer Registry and then calculated incidence trends using the Joinpoint Regression Program...
April 5, 2018: European Journal of Dermatology: EJD
Uwe Möginger, Sonja Grunewald, René Hennig, Chu-Wei Kuo, Falko Schirmeister, Harald Voth, Erdmann Rapp, Kay-Hooi Khoo, Peter H Seeberger, Jan C Simon, Daniel Kolarich
The glycome of one of the largest and most exposed human organs, the skin, as well as glycan changes associated with non-melanoma skin cancers have not been studied in detail to date. Skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are among the most frequent types of cancers with rising incidence rates in the aging population. We investigated the healthy human skin N - and O -glycome and its changes associated with BCC and SCC. Matched patient samples were obtained from frozen biopsy and formalin-fixed paraffin-embedded tissue samples for glycomics analyses using two complementary glycomics approaches: porous graphitized carbon nano-liquid chromatography electro spray ionization tandem mass spectrometry and capillary gel electrophoresis with laser induced fluorescence detection...
2018: Frontiers in Oncology
Carolyn J Heckman, Elizabeth Handorf, Melissa V Auerbach
Importance: The US Food and Drug Administration recommends that indoor tanners (ITs) be screened regularly for skin cancer (SC). Objective: To investigate the association between indoor tanning and SC screening. Design, Setting, and Participants: The 2015 National Health Interview Survey was a multistage, clustered, cross-sectional design with 30 352 US adults participating. The response rate for the sample adult data used in this study was 55...
April 4, 2018: JAMA Dermatology
Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes, Keila Karoline Magalhães-Marques, Gabriela Sarti Kinker, Sanseray da Silveira Cruz-Machado, Ana Maria de Lauro Castrucci
The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME) and macro-environments (TMaE) in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h...
April 3, 2018: International Journal of Molecular Sciences
P Rodríguez-Zamorano, L Puebla-Tornero, L M Martín-Santos, M L Román-Villaizán, A Guerra-Tapia
OBJECTIVES: Skin cancer (melanoma and non-melanoma) is the most common cancer in humans, with melanoma being the most aggressive. Due to the fact that ultraviolet (UV) radiation exposure is the only adjustable aetiological factor, UV protection is the essential preventive measure. Based on these grounds, a study was conducted in order to compare three population groups with different levels of knowledge about UV protection, as well as to determine any differences in sun exposure habits, and the level of awareness of the damaging effects of the sun on the skin...
March 28, 2018: Semergen
Lizette Anayo, Anette Magnussen, Alexis Perry, Mark Wood, Alison Curnow
OBJECTIVES: Non-melanoma skin cancers are the most frequently occurring type of cancer worldwide. They can be effectively treated using topical dermatological photodynamic therapy (PDT) employing protoporphyrin IX (PpIX) as the active photosensitising agent as long as the disease remains superficial. Novel iron chelating agents are being investigated to enhance the effectiveness and extend the applications of this treatment modality, as limiting free iron increases the accumulation of PpIX available for light activation and thus cell kill...
March 31, 2018: Lasers in Surgery and Medicine
Katherine A Turner, Jasmine M Manouchehri, Michael Kalafatis
Malignant melanoma is the most commonly diagnosed skin cancer associated with a high rate of metastasis. Low-stage melanoma is easily treated, but metastatic malignant melanoma is an extremely treatment-resistant malignancy with low survival rates. The application of recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) for the treatment of metastatic malignant melanoma holds considerable promise because of its selective proapoptotic activity towards cancer cells and not nontransformed cells...
March 28, 2018: Melanoma Research
Parvathi Haridas, Alexander P Browning, Jacqui A McGovern, D L Sean McElwain, Matthew J Simpson
BACKGROUND: Melanoma can be diagnosed by identifying nests of cells on the skin surface. Understanding the processes that drive nest formation is important as these processes could be potential targets for new cancer drugs. Cell proliferation and cell migration are two potential mechanisms that could conceivably drive melanoma nest formation. However, it is unclear which one of these two putative mechanisms plays a dominant role in driving nest formation. RESULTS: We use a suite of three-dimensional (3D) experiments in human skin tissue and a parallel series of 3D individual-based simulations to explore whether cell migration or cell proliferation plays a dominant role in nest formation...
March 27, 2018: BMC Systems Biology
Yuqi Yang, Weinan Guo, Jingjing Ma, Peng Xu, Weigang Zhang, Sen Guo, Lin Liu, Jinyuan Ma, Qiong Shi, Zhe Jian, Ling Liu, Gang Wang, Tianwen Gao, Zheyi Han, Chunying Li
Melanoma is the most lethal form of skin cancer with increasing incidence over the years. Due to its rapid proliferative and drastic metastatic capacity, the prognosis of melanoma remains dismal, although the targeted therapy and immunotherapy have gained revolutionary progress recently. Therefore, it is of necessity to further clarify the mechanism of melanoma pathogenesis for developing alternative treatment strategy. TRPV1 is a non-selective Ca2+ channel greatly involved in regulating cell apoptosis, proliferation, metabolism and cancer development, but its role in melanoma remains unknown...
March 23, 2018: Journal of Investigative Dermatology
J P Foy, F Kolb, E Routier, A Cavalcanti, J Lumbroso, G Tomasic, C Mateus, S Temam, C Robert, A Moya-Plana
Non-melanoma skin cancer (NMSC), the most common malignancy worldwide, includes Merkel cell carcinoma (MCC) and cutaneous squamous cell carcinoma (CSCC). Although CSCC are often associated with favorable outcomes, one to ten percent of cases develop regional metastatic disease, lowering significantly the survival rate. In contrast, MCC is aggressive with high rate of loco-regional disease (around 50%), resulting in a poor prognosis. This article is protected by copyright. All rights reserved.
March 24, 2018: Clinical Otolaryngology
E Gellén, G B Papp, E A Janka, T Gáll, G Paragh, G Emri, B Nemes, É Remenyik
BACKGROUND: The role of sun exposure in the development of melanoma and non-melanoma skin cancers is known; however, there are limited data on the contribution of pre-transplantation total sun burden (TSB) to the increased skin cancer risk in organ transplant recipients (OTRs). The importance of patient education about sun-safe behaviours is understood, but educations are often unsuccessful in OTRs. METHODS: A questionnaire-based cross-sectional study was performed with kidney transplant patients at a single academic centre to assess the pre- and post-transplant sun-exposure, sun-protection habits and skin cancers...
March 24, 2018: Photodermatology, Photoimmunology & Photomedicine
Erin Ibler, Gary Tran, Kelsey A Orrell, Linda Serrano, Sara Majewski, Kimberly A Sable, Rebecca Thiede, Anne E Laumann, Dennis P West, Beatrice Nardone
BACKGROUND: Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non-melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD. OBJECTIVE: The aim of this study is to determine if an association exists between MM and AD as well as for NMSC and AD. METHODS: A large urban, Midwestern, U...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Tomas Marek, B Matthew Howe, Kimberly K Amrami, Robert J Spinner
BACKGROUND: Perineural spread leading to brachial plexopathy has recently been described in cases of melanoma. The occurrence and mechanism for non-melanoma skin cancer spread to the brachial plexus is poorly understood. MATERIALS AND METHODS: A retrospective chart review of Mayo Clinic database was conducted to identify patients with non-melanoma skin cancer and brachial plexopathy between 2000 and 2017. Inclusion criteria were a history of non-melanoma skin cancer, a clinical diagnosis of brachial plexopathy, imaging features of perineural spread, and a positive biopsy showing tumor in a skin nerve...
March 20, 2018: World Neurosurgery
Elvira Moscarella, Simonetta Piana, Francesca Specchio, Athanassios Kyrgidis, Gianluca Nazzaro, Maite L Eliceche, Francesco Savoia, Leonardo Bugatti, Giorgio Filosa, Iris Zalaudek, Federica Scarfi, Mike Inskip, Cliff Rosendahl, John H Pyne, Graeme Siggs, Arzu K Toğral, Horatio Cabo, Lubomir Drlik, Aimilios Lallas, Caterina Longo, Giuseppe Argenziano
BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma. METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%)...
March 23, 2018: Australasian Journal of Dermatology
Sharon Lerman, Boaz Amichai, Gabriel Weinstein, Varda Shalev, Gabriel Chodick
BACKGROUND: The association between Parkinson's disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth. OBJECTIVE: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). METHODS: This historical cohort study used the data of 1.2 million adult members of a large health organization between 2000 and 2015...
March 22, 2018: Neuroepidemiology
Chau Yee Ng, Hsi Yen, Hui-Yi Hsiao, Shih-Chi Su
Skin is the largest human organ, our protection against various environmental assaults and noxious agents. Accumulation of these stress events may lead to the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Although modern targeted therapies have ameliorated the management of cutaneous malignancies, a safer, more affordable, and more effective strategy for chemoprevention and treatment is clearly needed for the improvement of skin cancer care. Phytochemicals are biologically active compounds derived from plants and herbal products...
March 22, 2018: International Journal of Molecular Sciences
Marta Podgórska, Monika Ołdak, Anna Marthaler, Alina Fingerle, Barbara Walch-Rückheim, Stefan Lohse, Cornelia S L Müller, Thomas Vogt, Mart Ustav, Artur Wnorowski, Magdalena Malejczyk, Sławomir Majewski, Sigrun Smola
Persistent genus β-HPV (human papillomavirus) infection is a major co-factor for non-melanoma skin cancer in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). Malignant EV lesions are particularly associated with HPV type 5 or 8. There is clinical and molecular evidence that HPV8 actively suppresses epithelial immunosurveillance by interfering with the recruitment of Langerhans cells, which may favor viral persistence. Mechanisms how persistent HPV8 infection promotes the carcinogenic process are, however, less well understood...
2018: Frontiers in Microbiology
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