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Non melanoma skin cancer

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https://www.readbyqxmd.com/read/28107579/experience-of-skin-cancer-and-contact-with-health-professionals-is-associated-with-increased-skin-cancer-knowledge-but-not-sun-safety-knowledge-or-behaviour
#1
Charlotte L Thomas, Pablo Fernández Peñas
The mortality and morbidity associated with melanoma is unquestionable, but its global incidence is greatly outnumbered by that of non-melanoma skin cancer (NMSC). The economic burden of NMSC is significant, falling within the US' top five most costly cancers (1) . In Australia, a high level of skin cancer awareness has been reported (2) . Public health campaigns and advice provided by individual health professionals seek to increase knowledge about skin cancer, risk factors and protective sun-safety behaviours...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107544/cutaneous-hpv8-and-mmupv1-e6-proteins-target-the-notch-and-tgf-%C3%AE-tumor-suppressors-to-inhibit-differentiation-and-sustain-keratinocyte-proliferation
#2
Jordan M Meyers, Aayushi Uberoi, Miranda Grace, Paul F Lambert, Karl Munger
Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation. Recent studies have shown that the E6 proteins of the cancer associated beta human papillomavirus (HPV) 5 and HPV8 inhibit NOTCH and TGF-β signaling. However, it is unclear whether disruption of these pathways may contribute to cutaneous HPV pathogenesis and carcinogenesis...
January 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28106907/subsequent-malignancies-among-long-term-survivors-of-hodgkin-lymphoma-and-non-hodgkin-lymphoma-a-pooled-analysis-of-german-cancer-registry-data-1990-2012
#3
Nadia Baras, Stefan Dahm, Jörg Haberland, Martin Janz, Katharina Emrich, Klaus Kraywinkel, Abdulgabar Salama
The increased risk of subsequent primary malignancies (SPM) in survivors of adult-onset Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) remains a challenging clinical problem worldwide. The German cancer registry database, pooled from 14 federal states, was used to calculate the standardized incidence ratio (SIR) and excess absolute risk (EAR) of SPM in 128 587 patients registered with first primary HL/NHL between 1990 and 2012. Conversely, SIRs were also calculated for a subsequent HL/NHL following other first cancers...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28103940/methodological-choices-affect-cancer-incidence-rates-a-cohort-study
#4
Hannah L Brooke, Mats Talbäck, Maria Feychting, Rickard Ljung
BACKGROUND: Incidence rates are fundamental to epidemiology, but their magnitude and interpretation depend on methodological choices. We aimed to examine the extent to which the definition of the study population affects cancer incidence rates. METHODS: All primary cancer diagnoses in Sweden between 1958 and 2010 were identified from the national Cancer Register. Age-standardized and age-specific incidence rates of 29 cancer subtypes between 2000 and 2010 were calculated using four definitions of the study population: persons resident in Sweden 1) based on general population statistics; 2) with no previous subtype-specific cancer diagnosis; 3) with no previous cancer diagnosis except non-melanoma skin cancer; and 4) with no previous cancer diagnosis of any type...
January 19, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28095542/the-two-faces-of-fractionated-photodynamic-therapy-increasing-efficacy-with-light-fractionation-or-adjuvant-use-of-fractional-laser-technology
#5
Margit L W Juhasz, Melissa K Levin, Ellen S Marmur
"Fractionated photodynamic therapy (PDT)" is a new term being used by dermatologists to describe advances in PDT technology including fractionated light or the adjuvant use of fractional lasers. Although dermatologists have used PDT since the early 1990s for the treatment of photodamage and precancerous lesions, newer developments in technology have allowed for the treatment of non-melanoma skin cancers (NMSCs), in ammatory disorders, and even uses in the eld of anti-aging. Recent developments in fractionated light therapy have allowed for PDT with dark intervals and two-fold illumination schemes to increase cellular damage and apoptosis...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28087048/-characteristics-and-risk-factors-for-recurrence-of-cutaneous-squamous-cell-carcinoma-with-conventional-surgery-and-surgery-with-delayed-intraoperative-margin-assessment
#6
Judith Domínguez-Cherit, Georgina Rodríguez-Gutiérrez, Verónica Narváez Rosales, Sonia Toussaint Caire, Verónica Fonte Avalos
BACKGROUND: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population...
January 10, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28071656/acg-clinical-guideline-preventive-care-in-inflammatory-bowel-disease
#7
Francis A Farraye, Gil Y Melmed, Gary R Lichtenstein, Sunanda V Kane
Recent data suggest that inflammatory bowel disease (IBD) patients do not receive preventive services at the same rate as general medical patients. Patients with IBD often consider their gastroenterologist to be the primary provider of care. To improve the care delivered to IBD patients, health maintenance issues need to be co-managed by both the gastroenterologist and primary care team. Gastroenterologists need to explicitly inform the primary care provider of the unique needs of the IBD patient, especially those on immunomodulators and biologics or being considered for such therapy...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28068941/looking-beyond-the-brain-to-improve-the-pathogenic-understanding-of-parkinson-s-disease-implications-of-whole-transcriptome-profiling-of-patients-skin
#8
Anu Planken, Lille Kurvits, Ene Reimann, Liis Kadastik-Eerme, Külli Kingo, Sulev Kõks, Pille Taba
BACKGROUND: Parkinson's Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss of dopaminergic neurons in the midbrain, however non-neuronal symptoms are also common. Although great advances have been made in the pathogenic understanding of Parkinson's Disease in the nervous system, little is known about the molecular alterations occurring in other non-neuronal organ systems. In addition, a higher rate of melanoma and non-melanoma skin cancer has been observed in the Parkinson's Disease population, indicating crosstalk between these diseases...
January 10, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28063902/application-of-aluminum-chloride-phthalocyanine-loaded-solid-lipid-nanoparticles-for-photodynamic-inactivation-of-melanoma-cells
#9
Patrícia L Goto, Marigilson P Siqueira-Moura, Antonio C Tedesco
Cutaneous melanoma is the most aggressive skin cancer and is particularly resistant to current therapeutic approaches. Photodynamic therapy (PDT) is a well-established photoprocess that is employed to treat some cancers, including non-melanoma skin cancer. Aluminum chloride phthalocyanine (ClAlPc) is used as a photosensitizer in PDT; however, its high hydrophobicity hampers its photodynamic activity under physiological conditions. The aim of this study was to produce solid lipid nanoparticles (SLN) containing ClAlPc using the direct emulsification method...
January 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28063168/phytochemicals-for-the-prevention-of-photocarcinogenesis
#10
Mary Katherine Montes de Oca, Ross L Pearlman, Sarah F McClees, Rebecca Strickland, Farrukh Afaq
Ultraviolet (UV) exposure has an array of damaging effects and is the main cause of skin cancer in humans. Non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma, is the most common type of cancer. Incidence of NMSC has increased due to greater UV radiation, increased life expectancy, and other changes in lifestyle; the annual cost of skin cancer treatment in the United States has increased concurrently to around eight billion dollars. Because of these trends, novel approaches to skin cancer prevention have become an important area of research to decrease skin cancer morbidity and defray the costs associated with treatment...
January 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28062833/cancer-incidence-in-cohorts-of-workers-in-the-rubber-manufacturing-industry-first-employed-since-1975-in-the-uk-and-sweden
#11
M Boniol, A Koechlin, T Sorahan, K Jakobsson, P Boyle
OBJECTIVES: Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK. METHODS: Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence ratios (SIRs), based on country-specific and period-specific incidence rates, were analysed for all cancers combined (except non-melanoma skin), bladder, lung, stomach cancer, leukaemia, non-Hodgkin's lymphoma and multiple myeloma...
January 6, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28060736/investigating-the-utility-of-human-melanoma-cell-lines-as-tumour-models
#12
Krista Marie Vincent, Lynne-Marie Postovit
Melanoma researchers utilize cell lines to model many tumour phenomena. It is thus important to understand similarities and differences between cell lines and the tumours that they represent, so that the optimal models can be chosen to answer specific research questions. Herein, we compared the transcriptomes of 42 melanoma cell lines to hundreds of tumours from The Cancer Genome Atlas and thousands of single melanoma cells. Tumour purity was accounted for using the ESTIMATE algorithm, so that differences likely resulting from non-tumour cells could be accounted for...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058215/more-than-skin-deep-potential-nicotinamide-treatment-applications-in-chronic-kidney-transplant-recipients
#13
REVIEW
Andrew G Bostom, Basma Merhi, Joanna Walker, Leslie Robinson-Bostom
Non-melanoma cutaneous carcinomas, or skin cancers, predominantly squamous cell carcinomas (SCCs), are the most common malignancies occurring in kidney transplant recipients (KTRs). Squamous cell carcinoma risk is dramatically elevated in KTRs, occurring at rates of up 45-250 times those reported in general populations. New non-melanoma skin cancers in KTRs with a prior non-melanoma skin cancer also develop at 3-times the rate reported in non-KTRs with the same clinical history. The unique aggressiveness of SCCs in KTRs increases patient morbidity, due to the high rate of new lesions requiring treatment, frequently surgical excision...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28056600/the-use-of-teledermoscopy-in-the-accurate-identification-of-cancerous-skin-lesions-in-the-adult-population-a-systematic-review
#14
Amy F Bruce, Jennifer A Mallow, Laurie A Theeke
Background The use of teledermoscopy in the diagnostic management of pre-cancerous and cancerous skin lesions involves digital dermoscopic images transmitted over telecommunication networks via email or web applications. Teledermoscopy may improve the accuracy in clinical diagnoses of melanoma skin cancer if integrated into electronic medical records and made available to rural communities, potentially leading to decreased morbidity and mortality. Objective and method The purpose of this paper is to present a systematic review of evidence on the use of teledermoscopy to improve the accuracy of skin lesion identification in adult populations...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28056100/chimeric-l2-based-virus-like-particle-vlp-vaccines-targeting-cutaneous-human-papillomaviruses-hpv
#15
Bettina Huber, Christina Schellenbacher, Saeed Shafti-Keramat, Christoph Jindra, Neil Christensen, Reinhard Kirnbauer
Common cutaneous human papillomavirus (HPV) types induce skin warts, whereas species beta HPV are implicated, together with UV-radiation, in the development of non-melanoma skin cancer (NMSC) in immunosuppressed patients. Licensed HPV vaccines contain virus-like particles (VLP) self-assembled from L1 major capsid proteins that provide type-restricted protection against mucosal HPV infections causing cervical and other ano-genital and oro-pharyngeal carcinomas and warts (condylomas), but do not target heterologous HPV...
2017: PloS One
https://www.readbyqxmd.com/read/28055220/incident-diagnoses-of-non-melanoma-skin-cancer-active-component-u-s-armed-forces-2005-2014
#16
Terrence Lee, Stephen B Taubman, Valerie F Williams
From 1 January 2005 through 31 December 2014, a total of 8,819 incident diagnoses of non-melanoma skin cancer (NMSC) (incidence rate 64.6 cases per 100,000 person-years [p-yrs]) were documented in the health records of 6,670 active component service members. During the surveillance period, there was a very slight decrease in the annual crude incidence rates of NMSC; rates of NMSC peaked in 2007 (68.3 cases per 100,000 p-yrs) and were at their lowest in 2013 (60.4 cases per 100,000 p-yrs). Increasing age was associated with increased risk of NMSC...
December 2016: MSMR
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#17
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28049538/risk-of-second-cancer-following-radiotherapy-for-prostate-cancer-a-population-based-analysis
#18
Nina-Sophie Hegemann, Anne Schlesinger-Raab, Ute Ganswindt, Claudia Hörl, Stephanie E Combs, Dieter Hölzel, Jürgen E Gschwend, Christian Stief, Claus Belka, Jutta Engel
BACKGROUND: To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy. METHODS: We compared men with radiotherapy only with those treated with radical prostatectomy only and those with radiotherapy after radical prostatectomy. Cumulative incidences of second cancers were calculated. Cox analyses were performed to identify determinants influencing second cancer incidence. RESULTS: Nineteen thousand five hundred thirty eight patients were analyzed...
January 3, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28045207/public-primary-and-secondary-skin-cancer-prevention-perceptions-and-knowledge-an-international-cross-sectional-survey
#19
S Seite, V Del Marmol, D Moyal, A Friedman
BACKGROUND: The incidence of melanoma and non-melanoma skin cancer is continuing to increase worldwide, with sun exposure serving as the primary external etiologic force in its development. Despite noticeable public health efforts, there continue to be gaps in public awareness and primary and secondary prevention mechanisms. This survey study sought to investigate preventative behaviors regarding sun exposure and skin cancer detection at an international scale. METHODS: A questionnaire was submitted, both online and by telephone, to a representative sample (based on official demographic statistics on gender, age and region) of people aged from 15 to 65 originating from 23 countries...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28045204/increased-non-melanoma-skin-cancer-risk-in-young-patients-with-inflammatory-bowel-disease-on-immunomodulatory-therapy-a-retrospective-single-centre-cohort-study
#20
J Clowry, J Sheridan, R Healy, S Deady, D Keegan, K Byrne, G Cullen, H Mulcahy, H Comber, A C Parnell, G Doherty, A Lally
BACKGROUND: Recent studies report an increased risk of non-melanoma skin cancer (NMSC) in immunosuppressed patients with inflammatory bowel disease (IBD). Concurrently, paediatric IBD incidence is rising, with more patients now exposed to immunomodulators from a younger age. OBJECTIVES: To investigate NMSC incidence and to examine the risk associated with immunomodulators in the development of NMSC in patients with IBD. METHODS: This was a retrospective single centre cohort study...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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