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Non melanoma skin cancer

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https://www.readbyqxmd.com/read/29044793/clustering-of-prevention-behaviours-in-patients-with-high-risk-primary-melanoma
#1
Adèle C Green, Maria Celia B Hughes, Lena A von Schuckmann, Kiarash Khosrotehrani, B Mark Smithers
OBJECTIVE: Because melanoma patients are at high risk of further disease, we aimed to study their melanoma prevention behaviours. METHODS: In a large cohort of patients newly diagnosed with high-risk melanoma in Queensland, Australia, we assessed clustering of preventive behaviours using latent class analysis. We assessed associated factors with prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) estimated by Poisson regression, and also if preventive behaviour was associated with better tumour prognosis at diagnosis...
October 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29043858/melanoma-segmentation-based-on-deep-learning
#2
Xiaoqing Zhang
Malignant melanoma is one of the most deadly forms of skin cancer, which is one of the world's fastest-growing cancers. Early diagnosis and treatment is critical. In this study, a neural network structure is utilized to construct a broad and accurate basis for the diagnosis of skin cancer, thereby reducing screening errors. The technique is able to improve the efficacy for identification of normally indistinguishable lesions (such as pigment spots) versus clinically unknown lesions, and to ultimately improve the diagnostic accuracy...
October 18, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29036257/improvement-of-actinic-keratoses-using-topical-dna-repair-enzymes-a-randomized-placebo-controlled-trial
#3
Marie Stoddard, Jennifer Herrmann, Lauren Moy, Ronald Moy
BACKGROUND: Actinic keratoses (AKs) are proliferations of abnormal keratinocytes, which may progress into non-melanoma skin cancers. Although multiple treatment modalities exist for AKs, their incidence continues to rise, making new methods of both prevention and treatment necessary. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of AKs and non-melanoma skin cancer (NMSC) in specific patient populations. OBJECTIVE: We investigated the efficacy of a topical DNA repair enzyme lotion as a field therapy for AKs...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29034706/chronic-lymphocytic-leukaemia-and-secondary-skin-malignancies
#4
Geraldine Kyle
Chronic lymphocytic leukaemia (CLL) is a non-Hodgkin lymphoma commonly occurring in older adults. Many people with CLL can go for years without requiring treatment. However, they have an increased risk of secondary cancers, specifically melanoma and non-melanoma skin cancers. Furthermore, these secondary cancers are frequently more aggressive in this cohort of patients. Health professionals working in haematology, dermatology and general practice have an opportunity to educate patients about risk factors and measures to aid prevention...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29031034/-potential-of-using-vitamin-d-as-an-adjuvant-treatment-of-malignant-melanoma
#5
B Bolerázska, E Ďurovcová, M Mareková
The incidence of malignant melanoma worldwide continues to grow despite the enormous advances in topical and systemic therapy. This increase is recorded regularly even in countries where, as a result of public health campaigns, dermatological examination and subsequent treatment have become more frequent. However, there have been reports of a stable or even decreasing mortality rate that seem to contradict the objective increase in its incidence. The well-known risk factors for malignant melanoma include sunburns and occasional sunbathing, whereas regular sunbathing is associated with a lower incidence...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29027001/cancer-incidence-in-urban-rural-and-densely-populated-districts-close-to-core-cities-in-bavaria-germany
#6
M Radespiel-Tröger, K Geiss, D Twardella, W Maier, M Meyer
OBJECTIVE: An ecologic study on the level of districts was performed to evaluate the possible association between district type and risk of cancer in Bavaria, Southern Germany. METHODS: Cancer incidence data for the years 2003-2012 were obtained from the population-based cancer registry Bavaria according to sex and cancer site. Data on district type, socio-economic area deprivation, particulate matter exposure, tobacco consumption, and alcohol consumption were obtained from publicly available sources...
October 12, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29024276/large-plaque-type-blue-nevus-with-cellular-nodules-a-rare-unrecognized-melanocytic-tumor
#7
C Baraldi, B Corti, M Lambertini, P A Fanti, A Patrizi, E Dika
A 24-year-old Caucasian woman referred to us due to the modification of a congenital skin lesion in her right scapular area over the past 10 months. Physical examination disclosed multiple blue/whitish nodules arising on a bluish oval plaque, 6 cm in maximum diameter (fig. 1). The patient's personal and family medical history were unremarkable and negative for melanoma and non-melanoma skin cancers. The entire lesion was totally excised. Microscopy revealed a multifocal dermal proliferation of fusiform and dendritic melanocytes arranged in irregular nodules characterized by many individual foci with the histologic appearance of common blue nevus involving the reticular dermis (fig...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#8
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
October 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28988380/tumor-infiltrating-immune-cells-as-potential-biomarkers-predicting-response-to-treatment-and-survival-in-patients-with-metastatic-melanoma-receiving-ipilimumab-therapy
#9
Tímea Balatoni, Anita Mohos, Eszter Papp, Tímea Sebestyén, Gabriella Liszkay, Judit Oláh, Anita Varga, Zsuzsanna Lengyel, Gabriella Emri, István Gaudi, Andrea Ladányi
Monoclonal antibodies targeting immune checkpoints are gaining ground in the treatment of melanoma and other cancers, and considerable effort is made to identify biomarkers predicting the efficacy of these therapies. Our retrospective study was performed on surgical tissue samples (52 lymph nodes and 34 cutaneous/subcutaneous metastases) from 30 patients with metastatic melanoma treated with ipilimumab. Using a panel of 11 antibodies against different immune cell types, intratumoral immune cell densities were determined and evaluated in relation to response to ipilimumab treatment and disease outcome...
October 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28982862/photodynamic-therapy-using-indolines-fused-triazoles-induces-mitochondrial-apoptosis-in-human-non-melanoma-bcc-cells
#10
Wan-Ping Hu, Kung-Kai Kuo, Gopal Chandru Senadi, Long-Sen Chang, Jeh-Jeng Wang
BACKGROUND/AIM: Cancer is one of the most dreadful diseases in humans and among them non-melanoma skin cancer (NMSC) is an increasing problem in the world, that occurs more frequently in people with fair skin. Photodynamic therapy (PDT), a non-invasive treatment is widely used for the prevention and treatment of BCC cells. We previously reported an efficient synthesis of novel indolines-fused-triazoles and studied their photophysical studies. This study delineated the signaling pathways involved in the PDT effect of triazoles on BCC cells under UVA irradiation...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28976029/epigenetics-of-skin-cancer-interventions-by-selected-bioactive-phytochemicals
#11
REVIEW
Dhanamjai Penta, Bagganahalli S Somashekar, Syed Musthapa Meeran
The prevalence and risk of skin cancer have been increasing over past three decades. Two major types of skin cancer observed in humans are melanoma and non-melanoma. Non-melanoma further subdivided into basal cell carcinoma and squamous cell carcinoma. Melanoma arises from melanocyte which locates at the bottom layer of skin epidermis, which primarily protects the skin from being exposed to external factors. Melanoma is less common among all other types of skin cancers but causes higher mortality. Epigenetic regulation associated with the transcriptional activation and inactivation of genes plays a major role in various disease progression including skin cancer...
October 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28973033/integrative-genetic-analysis-suggests-that-skin-color-modifies-the-genetic-architecture-of-melanoma
#12
Imge Hulur, Andrew D Skol, Eric R Gamazon, Nancy J Cox, Kenan Onel
Melanoma is the deadliest form of skin cancer and presents a significant health care burden in many countries. In addition to ultraviolet radiation in sunlight, the main causal factor for melanoma, genetic factors also play an important role in melanoma susceptibility. Although genome-wide association studies have identified many single nucleotide polymorphisms associated with melanoma, little is known about the proportion of disease risk attributable to these loci and their distribution throughout the genome...
2017: PloS One
https://www.readbyqxmd.com/read/28966807/skin-cancer-epidemics-in-the-elderly-as-an-emerging-issue-in-geriatric-oncology
#13
REVIEW
Simone Garcovich, Giuseppe Colloca, Pietro Sollena, Bellieni Andrea, Lodovico Balducci, William C Cho, Roberto Bernabei, Ketty Peris
Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct clinical presentations in the elderly patient and represents a challenging question in terms of clinical management. NMSC includes the basal cell carcinoma and cutaneous squamous cell carcinoma and presents a wide disease spectrum in the elderly population, ranging from low-risk to high-risk tumours, advanced and inoperable disease...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28962521/editor-s-highlight-ppar%C3%AE-%C3%AE-and-ppar%C3%AE-inhibit-melanoma-tumorigenicity-by-modulating-inflammation-and-apoptosis
#14
Michael G Borland, Pei-Li Yao, Ellen M Kehres, Christina Lee, Amanda M Pritzlaff, Elizabeth Ola, Ashley L Wagner, Brooke E Shannon, Prajakta P Albrecht, Bokai Zhu, Boo-Hyon Kang, Gavin P Robertson, Frank J Gonzalez, Jeffrey M Peters
Skin tumorigenesis results from DNA damage, increased inflammation, and evasion of apoptosis. The peroxisome proliferator-activated receptors (PPARs) can modulate these mechanisms in non-melanoma skin cancer. However, limited data exists regarding the role of PPARs in melanoma. This study examined the effect of proliferator-activated receptor-β/δ (PPARβ/δ) and PPARγ on cell proliferation, anchorage-dependent clonogenicity, and ectopic xenografts in the UACC903 human melanoma cell line. Stable overexpression of either PPARβ/δ or PPARγ enhanced ligand-induced expression of a PPARβ/δ/PPARγ target gene in UACC903 cell lines as compared with controls...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28954292/all-cancers-estimated-incidence-mortality-and-prevalence-of-all-cancers-excluding-non-melanoma-skin-cancer-in-2012
#15
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28951753/comparison-of-electronic-brachytherapy-and-mohs-micrographic-surgery-for-the-treatment-of-early-stage-non-melanoma-skin-cancer-a-matched-pair-cohort-study
#16
Rakesh Patel, Robert Strimling, Stephen Doggett, Mark Willoughby, Kenneth Miller, Lawrence Dardick, Erick Mafong
PURPOSE: High-dose-rate electronic brachytherapy (EBT) provides a non-surgical treatment option for non-melanoma skin cancer (NMSC). This matched-pair cohort study compared the outcomes of treatment with EBT to those of Mohs micrographic surgery (MMS) in patients with NMSC. MATERIAL AND METHODS: At four treatment centers, patients treated with EBT were case matched to patients treated with MMS based on retrospectively-collected patient age, lesion size, location and type, and year of treatment...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28944758/non-melanoma-skin-cancers-in-african-american-solid-organ-transplant-recipients-regional-bias-or-a-real-need-for-surveillance
#17
Liliane Borik, Yevgeniy Balagula, Ginette A Hinds, Manisha J Loss
No abstract text is available yet for this article.
September 23, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28942040/epidermal-long-non-coding-rnas-are-regulated-by-ultraviolet-irradiation
#18
Kyu-Han Kim, Hyoung-June Kim, Tae Ryong Lee
Ultraviolet (UV) radiation causes the harmful effects on skin by the photochemical reaction and gene expression regulation. Recent evidences have shown that long non-coding RNAs (lncRNAs) play critical roles in a diverse range of biological functions. However, research on the effects of UV irradiation on lncRNA expression in epidermal cells is limited. The aim of this study was to identify changes in the expression profile of lncRNAs after UVB irradiation. To accomplish this, we performed a microarray analysis of both mRNA and lncRNA expression levels in irradiated skin cells...
December 30, 2017: Gene
https://www.readbyqxmd.com/read/28936477/clinical-characteristics-of-non-melanoma-skin-cancers-recurring-within-5-years-after-mohs-micrographic-surgery-single-institution-retrospective-chart-review
#19
Tina Vajdi, Robert Eilers, Shang I Brian Jiang
BACKGROUND: Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases. OBJECTIVE: We examined specific clinical characteristics associated with NMSC recurrences following MMS. METHODS: We employed a retrospective chart review of the 1467 cases of NMSC that underwent MMS at UC San Diego from January 1, 2008 through December 31, 2009...
January 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28925583/decreasing-incidence-of-cancer-after-liver-transplantation-a-nordic-population-based-study-over-three-decades
#20
A Nordin, F Åberg, E Pukkala, C R Pedersen, H H Storm, A Rasmussen, W Bennet, M Olausson, H Wilczek, B-G Ericzon, S Tretli, P-D Line, T H Karlsen, K M Boberg, H Isoniemi
Cancer remains one of the most serious long-term complications after liver transplantation (LT). Data for all adult LT patients between 1982 and 2013 was extracted from the Nordic Liver Transplant Registry. Through linkage with respective national cancer-registry data, we calculated standardized incidence ratios (SIRs) based on country, sex, calendar time, and age-specific incidence rates. Altogether 461 cancers were observed in 424 individuals out the 4246 LT patients during a mean 6.6-year follow-up. The overall SIR was 2...
September 19, 2017: American Journal of Transplantation
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