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https://www.readbyqxmd.com/read/29442526/cost-efficacy-analysis-of-3-diclofenac-sodium-ingenol-mebutate-and-3-75-imiquimod-in-the-treatment-of-actinic-keratosis
#1
Steven Nisticò, Ester Del Duca, Valeria Torchia, Micaela Gliozzi, Ugo Bottoni, Carolina Muscoli
Actinic keratosis (AK) is a clinical condition characterized by keratinocytic dysplastic lesions of the epidermis, affecting individuals chronically exposed to sunlight. Topical therapies allow the treatment of a whole area of affected skin and currently include diclofenac sodium gel, 5-fluorouracil cream, 5-fluorouracil and acetylsalicylic acid solution, imiquimod cream, and ingenol mebutate gel. Due to the comparable efficacy of 3% diclofenac, ingenol mebutate, and 3.75% imiquimod in treating AK multiple lesions, a pharmacoeconomic evaluation of cost-effectiveness of the three treatments was needed...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29442024/anti-cancer-activity-of-bacillus-amyloliquefaciens-ak-0-through-cyclin-d1-proteasomal-degradation-via-gsk3%C3%AE-dependent-phosphorylation-of-threonine-286
#2
Gwang Hun Park, Hun Min Song, Young Soo Kim, Yongho Jeon, Jin Suk Koo, Hyung Jin Jeong, Jin Boo Jeong
Microorganisms have been regarded as important sources of novel bioactive natural products. In this study, we evaluated the anti-cancer activity and the potential mechanism of Bacillus amyloliquefaciens AK-0 newly isolated from the rhizosphere soil of Korean ginseng. The ethyl acetate fraction from the culture medium of B. amyloliquefaciens AK-0 (EA-AK0) inhibited markedly the proliferation of human colorectal cancer cells such as HCT116, SW480, LoVo and HT-29. EA-AK0 effectively decreased cyclin D1 protein level in human colorectal cancer cells, while cyclin D1 mRNA level was not changed by EA-AK0 treatment...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29422823/anaphylaxis-in-poland-the-epidemiology-and-direct-costs
#3
Karina Jahnz-Rozyk, Filip Raciborski, Andrzej M Śliwczyński, Anna Kłak, Jarosław Pinkas
Introduction: Epidemiological data on anaphylaxis have been underestimated both in Poland and worldwide. Aim: To evaluate the prevalence of anaphylaxis in Poland, including a classification by gender, age and residential region. Material and methods: The data used in the analysis were derived from two sources, the National Health Fund records of healthcare services for 2008-2015 (official statistics) and a questionnaire-based survey conducted in 2015 on a sample of 305 allergists practicing in different regions of Poland...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29417799/a-synthesis-of-the-world-s-guidelines-on-photodynamic-therapy-for-non-melanoma-skin-cancer
#4
Colin A Morton
Photodynamic therapy (PDT), using topically administered photosensitizing agents, is widely approved as a treatment for certain nonmelanoma skin cancers. As a tissue-sparing non-surgical modality, there is great potential for PDT to enhance the choice of therapies available to treat, and potentially prevent, skin cancer. Treatment-specific guidelines have assessed the evidence for various photosensitizing agents and light sources, dosimetry, and evaluate reported adverse effects. Discomfort is frequently experienced during treatment but no analgesia was required in most pivotal lesion-directed studies...
February 7, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29414904/photodynamic-therapy-activated-by-intense-pulsed-light-in-the-treatment-of-nonmelanoma-skin-cancer
#5
Domenico Piccolo, Dimitra Kostaki
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC)...
February 7, 2018: Biomedicines
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#6
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29407554/topical-formulations-of-delta-aminolevulinic-acid-for-the-treatment-of-actinic-keratosis-characterization-and-efficacy-evaluation
#7
Laura Risaliti, Vieri Piazzini, Maria Giuseppina Di Marzo, Luigi Brunetti, Roberto Cecchi, Patrizia Lencioni, Anna Rita Bilia, Maria Camilla Bergonzi
Actinic keratosis (AK) is a pre-cancerous disease, with worldwide increasing incidence, which consists in squamous cutaneous lesion caused by excessive exposure to ultraviolet radiation. An established treatment option is photodynamic therapy (PDT), based on light, oxygen and a photosensitizer. The most widely used is 5-aminolevulinic acid (ALA) which however, being a hydrophilic molecule, has difficultly penetrating the skin to achieve the desired therapeutic effect. To solve this limit, the present study provides for the development of three galenic gel formulations (Natrosol, Sepigel and Carbopol) containing 10% w/w of ALA for the treatment of AK with PDT and their comparison with a lipophilic cream used in the Hospital...
January 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29397554/the-role-of-intralipid-emulsion-in-the-rat-model-of-digoxin-intoxication
#8
Cansu Arslan Turan, Tuba Cimilli Ozturk, Ebru Unal Akoglu, Rohat Ak, Kemal Aygun, Ali Sahiner, Engin Sumer, Adnan Somay, Ozge Ecmel Onur
Although the mechanism of action is not well known, intravenous lipid emulsion (ILE) has been shown to be effective in the treatment of lipophilic drug intoxications. It is thought that, ILE probably separates the lipophilic drugs from target tissue by creating a lipid-rich compartment in the plasma. The second theory is that ILE provides energy to myocardium with high-dose free fatty acids activating the voltage-gated calcium channels in the myocytes. In this study, effects of ILE treatment on digoxin overdose were searched in an animal model in terms of cardiac side effects and survival...
February 3, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29382550/neuroprotective-effect-of-sirt2-specific-inhibitor-ak-7-against-acute-cerebral-ischemia-is-p38-activation-dependent-in-mice
#9
Danhong Wu, Wenmei Lu, Zhenyu Wei, Ming Xu, Xueyuan Liu
Cerebral ischemic is the most common cause of stroke with high morbidity, disability and mortality. Sirtuin-2 (Sirt2), a vitally important NAD+-dependent deacetylase which has been widely researched in central nervous system diseases, has also been identified as a promising treatment target by using its specific inhibitors such as AK-7. In this study, we found that P38 was specifically activated after focal cerebral ischemia injury, and it was also significantly activated after AK-7 administration in a concentration-dependent manner in vitro and in vivo...
January 27, 2018: Neuroscience
https://www.readbyqxmd.com/read/29368865/daylight-photodynamic-therapy-experience-in-the-treatment-of-actinic-keratosis-in-san-gallicano-institute-of-rome-and-a-review-of-literature
#10
Anna Carbone, Isabella Sperduti, Paola DE Simone, Paolo Piemonte, Angela Ferrari, Pierluigi Buccini, Vitaliano Silipo, Alessandra Iorio, Pasquale Frascione, Laura Eibenschutz
BACKGROUND: Actinic keratosis (AK) is a photo-induced skin lesion. It has been considered by several authors as in situ squamous cell carcinoma (SCC), that can evolve to invasive SCC (iSCC). Given the malignant potential and because it's impossible predict which AK will evolve in iSCC, it's necessary to treat each lesion. Multiple therapeutic approaches have been described to treat AKs. In addition to the topical drugs, photodynamic therapy (PDT) has become an established therapeutic modality for grade I and II of AKs of face and scalp...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29356164/tracking-actinic-keratosis-of-face-and-scalp-treated-with-0-015-ingenol-mebutate-to-identify-clinical-and-dermoscopic-predictors-of-treatment-response
#11
R Pampena, E Benati, S Borsari, C Bombonato, M Lombardi, M Raucci, M Mirra, A Lallas, Z Apalla, I Papadimitriou, E Moscarella, A Kyrgidis, G Argenziano, G Pellacani, C Longo
BACKGROUND: Ingenol mebutate (IngMeb) 0.015% gel is an approved field treatment option for non-hyperkeratotic non-hypertrophic actinic keratosis (AKs) of face and scalp. Efficacy of IngMeb has been assessed only on a clinical ground, in the majority of studies. Dermoscopy is a pivotal tool for the diagnosis of AK, while its role in evaluating the response to non-surgical therapies for AK has not been fully defined. OBJECTIVES: Our study aims to determine if some dermoscopic features of AK of the face and scalp areas, may independently predict the response to IngMeb therapy...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29355904/a-multi-centre-open-investigator-initiated-phase-iv-clinical-trial-to-evaluate-the-efficacy-and-safety-of-ingenol-mebutate-gel-0-015-on-the-face-and-scalp-and-0-05-on-the-trunk-and-extremities-in-korean-patients-with-actinic-keratosis-perfect
#12
Y C Kim, J Y Yang, J S Yoon, S J Jo, H H Ahn, K-H Song, D-Y Lee, K-Y Chung, Y-H Won, I-H Kim
BACKGROUND: Ingenol mebutate gel is a novel, field-directed topical treatment for actinic keratosis (AK). Most pivotal studies have targeted Western populations. No clinical study has been conducted to investigate its efficacy and safety in Asian populations. OBJECTIVES: To evaluate the efficacy and safety of ingenol mebutate gel for treating AK of face/scalp and trunk/extremities in a large Asian (Korean) population. METHODS: In this multi-centre, open-label, interventional, parallel group, prospective phase 4 study (PERFECT, NCT02716714), the eligible subjects were allocated into either the face/scalp or the trunk/extremities group, according to their selected treatment area location...
January 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29351725/daylight-mediated-photodynamic-therapy-with-methyl-aminolevulinate-in-actinic-keratosis-treatment
#13
Shantel D J Demay, Kunal Sharma, Sheetal Sapra, Rahul Sapra, Priya Sapra
BACKGROUND: Research has shown daylight-mediated photodynamic therapy (PDT) for the treatment of actinic keratosis (AK) to be effective, tolerable, and convenient, with excellent patient satisfaction and cosmesis. Although success has been demonstrated in areas with similar latitudes to Switzerland and Scandinavia, this treatment has not been studied in a Canadian population. OBJECTIVES: The purpose of this study is to investigate the effectiveness, safety, and patient satisfaction of daylight-mediated methyl 5-aminolevulinate (MAL)-PDT to make recommendations for its use in Canadian practice...
January 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29351353/the-contributions-of-phonological-awareness-alphabet-knowledge-and-letter-writing-to-name-writing-in-children-with-specific-language-impairment-and-typically-developing-children
#14
Stacey L Pavelko, R Jane Lieberman, Jamie Schwartz, Debbie Hahs-Vaughn
Purpose: Name writing is one aspect of emergent writing that has been used to understand emergent literacy development. Name-writing skills and the relationship of name writing to other emergent literacy skills have not been studied extensively in children with specific language impairment (SLI). Children with SLI consistently demonstrate delays in phonological awareness (PA), alphabet knowledge (AK), print awareness, and emergent writing. The purpose of this study was to examine the contributions of PA, AK, and letter writing to name writing in children with SLI and typically developing (TD) children...
January 19, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29339061/dose-dependent-photochemical-photothermal-toxicity-of-indocyanine-green-based-therapy-on-three-different-cancer-cell-lines
#15
Mustafa Kemal Ruhi, Ayşe Ak Can, Murat Gülsoy
The Food and Drug Administration-approved Indocyanine Green can be used as a photosensitizer to kill cancer cells selectively. Although indocyanine green is advantageous as a photosensitizer in terms of strong absorption in the near-infrared region, indocyanine green-based cancer treatment is still not approved as a clinical method. Some reasons for this are aggregation at high concentrations, rapid clearance of the photosensitizer from the body, low singlet oxygen quantum yield, and the uncertainty concerning its action mechanism...
January 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29322431/daylight-photodynamic-therapy-versus-5-fluorouracil-for-the-treatment-of-actinic-keratosis-a-case-series
#16
Gaston Nestor Galimberti
INTRODUCTION: The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. METHODS: Five male subjects (mean age 70 years) with grade I-III AK on the face/scalp were enrolled...
January 10, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29311041/5-fluorouracil-chemowraps-for-the-treatment-of-multiple-actinic-keratoses
#17
Lucie Peuvrel, Mélanie Saint-Jean, Gaëlle Quereux, Anabelle Brocard, Marie Le Moigne, Cécile Frénard, Amir Khammari, Brigitte Dreno
Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29298778/acanthamoeba-keratitis-in-194-patients-risk-factors-for-bad-outcomes-and-severe-inflammatory-complications
#18
Nicole Carnt, Dana Robaei, Darwin C Minassian, John K G Dart
BACKGROUND/AIMS: To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC). METHODS: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10...
January 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296556/rapid-resolution-of-stromal-keratitis-with-the-assistance-of-oral-voriconazole-in-resistant-acanthamoeba-keratitis
#19
Tzu-Yu Hou, Yun-Chen Chen, Chih-Chien Hsu
Acanthamoeba keratitis (AK) is an unusual infectious disease of the cornea which sometimes leads to blindness. We report the experience of adding oral voriconazole in conjunction with topical antiacanthamoebic drops to treat refractory AK. A 20-year-old girl experienced a deep stromal keratitis with large epithelial defect in the left eye, suspected as AK. The initial best-corrected visual acuity (BCVA) of the eye was counting finger. She received topical chlorhexidine 0.02% and voriconazole 1% during the first 14 days but in vain...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282394/treatment-of-multiple-actinic-keratosis-and-field-of-cancerization-with-topical-piroxicam-0-8-and-sunscreen-50-in-organ-transplant-recipients-a-series-of-10-cases
#20
Virginia Garofalo, Alessandra Ventura, Sara Mazzilli, Laura Diluvio, Luca Bianchi, Luca Toti, Giuseppe Tisone, Massimo Milani, Elena Campione
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers...
September 2017: Case Reports in Dermatology
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