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https://www.readbyqxmd.com/read/29665991/differential-proteomic-analysis-of-actinic-keratosis-bowen-s-disease-and-cutaneous-squamous-cell-carcinoma-by-label-free-lc-ms-ms
#1
Ali Azimi, Kimberley L Kaufman, Marina Ali, Jonathan Arthur, Steven Kossard, Pablo Fernandez-Penas
BACKGROUND: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent. OBJECTIVE: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. METHODS: Microdissected formalin-fixed paraffin embedded samples of normal epidermis (n = 4, pooled), AK (n = 10), BD (n = 10) and cSCC (n = 10) were analyzed by mass spectrometry...
April 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29663426/comparison-of-blue-and-white-lamp-light-with-sunlight-for-daylight-mediated-5-ala-photodynamic-therapy-in-vivo
#2
Kayla Marra, Ethan P LaRochelle, M Shane Chapman, P Jack Hoopes, Karina Lukovits, Edward V Maytin, Tayyaba Hasan, Brian W Pogue
Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light, and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery...
April 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29617135/discovery-of-novel-dual-mechanism-of-action-src-signaling-and-tubulin-polymerization-inhibitors-kx2-391-and-kx2-361
#3
Michael P Smolinski, Yahao Bu, James Clements, Irwin H Gelman, Taher Hegab, David L Cutler, Jane W S Fang, Gerald Fetterly, Rudolf Kwan, Allen Barnett, Johnson Y N Lau, David G Hangauer
The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clinical candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clinical trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Compound 2 is a phase 1 clinical trial candidate that is likely to provide a first in class treatment of malignant glioblastoma and induces 30% long term complete tumor remission in animal models...
April 4, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29601904/protoporphyrin-ix-formation-after-application-of-methyl-aminolevulinate-on-the-face-and-scalp-with-and-without-prior-curettage
#4
Ida M Heerfordt, Giedre Bieliauskiene, Hans Christian Wulf
BACKGROUND: Pulse photodynamic therapy (PDT) is carried out as classical PDT except that methyl aminolaevulinate (MAL) is removed after 30 min. Protoporphyrin IX (PpIX) accumulation becomes lower after 3 h in pulse-PDT than in classical PDT, but pulse-PDT still has full treatment effect on actinic keratosis (AK). The present study aimed to investigate when PpIX formation in classical PDT without curettage reaches the PpIX level in pulse-PDT with curettage in the skin of the face and scalp...
March 27, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29593028/5-fluorouracil-enhances-protoporphyrin-ix-accumulation-and-lesion-clearance-during-photodynamic-therapy-of-actinic-keratoses-a-mechanism-based-clinical-trial
#5
Edward V Maytin, Sanjay Anand, Margo Riha, Sara Lohser, Alejandra Tellez, Rim Ishak, Lauren Karpinski, Janine Sot, Bo Hu, Anton Denisyuk, Scott C Davis, Angela Kyei, Allison Vidimos
PURPOSE: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear in terms of proper sequence, timing, and mechanism. This clinical study explored mechanisms of action for neoadjuvantal 5FU and PDT for treatment of AK. EXPERIMENTAL DESIGN: A bilaterally controlled trial (17 patients) was performed...
March 28, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29587662/randomized-clinical-trial-testing-the-efficacy-and-safety-of-0-5-colchicine-cream-versus-photodynamic-therapy-with-methyl-aminolevulinate-in-the-treatment-of-skin-field-cancerization-study-protocol
#6
Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot
BACKGROUND: The primary clinical manifestation of skin field cancerization is the presence of actinic keratoses (AKs). Current treatments for AKs related to skin field cancerization include photodynamic therapy (PDT) and colchicine. The objective of this study is to evaluate the efficacy and safety of 0.5% colchicine cream versus PDT with methyl aminolevulinate (MAL-PDT) in the treatment of skin field cancerization. METHODS: In a randomized controlled and open clinical trial with a blind histopathological and immunohistochemical analysis, 36 patients with up to 10 AKs on their forearms will be included from the outpatient clinic...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29582369/field-cancerization-therapies-for-management-of-actinic-keratosis-a-narrative-review
#7
REVIEW
Nathan Jetter, Neha Chandan, Stephanie Wang, Maria Tsoukas
Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Field-directed therapies thus have the potential to address subclinical damage, reduce AK recurrence rates, and potentially reduce the risk of squamous cell carcinoma (SCC) development...
March 26, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#8
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29580152/epidemiology-risk-factors-and-clinical-outcomes-in-severe-microbial-keratitis-in-south-india
#9
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Matthew J Burton
PURPOSE: Here, we report risk factors associated with outcome in severe bacterial keratitis (BK), fungal keratitis (FK), and Acanthamoeba keratitis (AK) in India. METHODS: Prospective observational cohort study conducted in Aravind Eye Hospital, India. Adults presenting with severe microbial keratitis (MK) were enrolled (size ≥3 mm) and followed to 21 days post-enrolment. Ulcer clinical features were recorded at presentation. Outcomes by final visit were classified as good (completely healed or reduced infiltrate size) or poor (enlarged infiltrate size, perforated, or surgery performed)...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29558357/-the-coexistence-of-systemic-lupus-erythematosus-and-psoriasis-diagnostic-and-therapeutic-problems
#10
Aleksandra Szuster, Justyna Tyburek, Karolina Widłak, Piotr Wilkołek, Karol Wiśniewski, Maria Majdan
The coexistence of systemic lupus erythematosus (SLE) and psoriasis is rarely observed in everyday clinical practice. Apart from providing a correct diagnosis, a major difficulty is to provide a proper treatment. In this case, for example, the use of systemic glucocorticosteroids may have a negative effect on the course of psoriasis, whereas phototherapy, which is widely practiced in psoriasis, may cause SLE exacerbation. The aim of the paper is to present the difficulty along the diagnostic process and in choosing the best type of treatment for patients with a coexistence of SLE and psoriasis and also a review of the subject-related literature...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29530340/efficacy-and-safety-of-topical-sr-t100-gel-in-treating-actinic-keratosis-in-taiwan-a-phase-iii-randomized-double-blind-vehicle-controlled-parallel-trial
#11
Chao-Chun Yang, Tak-Wah Wong, Chih-Hung Lee, Chien-Hui Hong, Chung-Hsing Chang, Feng-Jie Lai, Shang-Hung Lin, Ching-Chi Chi, Tzu-Kai Lin, Hsi Yen, Chin-Han Wu, Hamm-Ming Sheu, Cheng-Che E Lan
BACKGROUND: Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES: To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS: A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two clinically visible AK were enrolled and a punch biopsy was performed on one of the AK to confirm the diagnosis. This study consisted of up to 16-week treatment and 8-week post-treatment periods...
March 2, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29524177/components-of-metabolic-syndrome-in-relation-to-plasma-levels-of-retinol-binding-protein-4-rbp4-in-a-cohort-of-people-aged-65-years-and-older
#12
M Majerczyk, P Kocełak, P Choręza, H Arabzada, A J Owczarek, M Bożentowicz-Wikarek, A Brzozowska, A Szybalska, M Puzianowska-Kuźnicka, T Grodzicki, A Więcek, M Olszanecka-Glinianowicz, J Chudek
PURPOSE: Elevated plasma concentration of retinol binding protein 4 (RBP4) has recently emerged as a potential risk factor as a component of developing metabolic syndrome (MS). Therefore, this study aimed to analyse the relationship between components of MS and concentrations of plasma RBP4 in a population of subjects 65 years and older. METHODS: The study sample consisted of 3038 (1591 male) participants of the PolSenior study, aged 65 years and older. Serum lipid profile, concentrations of RBP4, glucose, insulin, C-reactive protein, IL-6, and activity of aminotransferases were measured...
March 9, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29522942/anxiety-disorders-and-figural-fluency-a-measure-of-executive-function
#13
B Gulpers, A Lugtenburg, M Zuidersma, F R J Verhey, R C Oude Voshaar
BACKGROUND: Anxiety possibly interferes with executive functioning, although most studies rely on anxiety symptoms or lack control for comorbid depression. The objective of the present study is to examine the association between executive functioning and (individual) anxiety disorders with ak,ld without controlling for depression. METHOD: Generalized anxiety disorder (GAD), panic disorder with and without agoraphobia, agoraphobia, social phobia, as well as depressive disorder according to DSM-IV criteria were assessed with the Mini International Neuropsychiatric Interview in 82,360 community-dwelling people participating in the Lifelines cohort...
February 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29511116/prevalence-and-treatment-of-spontaneous-intracranial-artery-dissections-in-patients-with-acute-stroke-due-to-intracranial-large-vessel-occlusion
#14
Marc-Antoine Labeyrie, Vittorio Civelli, Peggy Reiner, Armand Aymard, Jean-Pierre Saint-Maurice, Akli Zetchi, Emmanuel Houdart
OBJECTIVE: To identify the prevalence and therapeutic consequences of spontaneous intracranial artery dissection (IAD) at the acute phase of ischemic stroke. METHODS: We reviewed clinical and imaging data of consecutive patients attending our center for mechanical thrombectomy (MT) between January 2012 and November 2017. IAD was defined according to published criteria and our own angiographic criteria (no clot following MT, and normalization of the vessel caliber after stenting)...
March 6, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29510939/macroscopic-complete-resection-is-not-associated-with-improved-survival-in-patients-with-malignant-pleural-mesothelioma
#15
Hasan Fevzi Batirel, Muzaffer Metintas, Hale Basak Caglar, Guntulu Ak, Perran Fulden Yumuk, Rengin Ahiskali, Emine Bozkurtlar, Nural Bekiroglu, Tunc Lacin, Bedrettin Yildizeli, Mustafa Yuksel
OBJECTIVE: Macroscopic complete resection (MCR) is the recommended surgical strategy in malignant pleural mesothelioma. Our objective was to analyze whether MCR influences survival in malignant pleural mesothelioma. METHODS: Between 2002 and 2016, 154 patients underwent pleurectomy decortication (n = 90), extrapleural pneumonectomy (n = 42), or exploratory/diagnostic procedures (n = 22) in a single institution. Patient data were recorded in a prospective database...
February 9, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29505863/impact-of-topical-fluorouracil-cream-on-costs-of-treating-keratinocyte-carcinoma-nonmelanoma-skin-cancer-and-actinic-keratosis
#16
Jean Yoon, Ciaran S Phibbs, Adam Chow, Martin A Weinstock
BACKGROUND: It is unknown whether treatment costs of Keratinocyte Carcinoma (KC) and Actinic Keratosis (AK) can be lowered by spending more on chemoprevention. OBJECTIVE: We examine the impact of one-course treatment of topical fluorouracil on the face and ears on KC and AK treatment costs over three years. METHODS: The VAKCC trial compared the efficacy of topical fluorouracil cream, 5%, vs vehicle control cream for reducing KC risk. Trial data and administrative data on costs and utilization were analyzed to measure post-randomization encounters and treatment costs for KC and AK care...
March 2, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29495902/pharmacological-prophylaxis-of-postpartum-exacerbation-in-depressive-and-anxiety-symptoms-a-retrospective-study
#17
Faruk Uguz, Elif Subasi, Fadime Dalboy, Mehmet Ak
The aim of this study was to investigate the efficacy of prophylactic treatment with antidepressants for the prevention of postpartum exacerbation in depressive or anxiety symptoms. The study included data on 33 patients who were followed from pregnancy to the postpartum period at the Department of Psychiatry of a university Hospital. Psychiatric diagnoses were determined by means of a structured clinical interview. The severity of depressive and anxiety symptoms were assessed by means of Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A), respectively...
March 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29489051/the-depth-of-follicular-extension-in-actinic-keratosis-correlates-with-the-depth-of-invasion-in-squamous-cell-carcinoma-implication-for-clinical-treatment
#18
M T Fernández-Figueras, X Saenz, P Vargas, C T Thompson, C Carrato, L Puig, C Ferrándiz, A Ariza
BACKGROUND: Actinic keratosis (AK) may show extension down follicules, not only in cases with full-thickness epidermal atypia ("bowenoid" AK), but also in cases with atypia limited to the epidermal basalis. Previous studies have demonstrated that in bowenoid AK, follicular extension is usually superficial, being limited to the upper follicular segment. Little is known about the depth of follicular involvement in cases of iSCC arising from AK and the role of the follicle in iSCC pathogenesis...
February 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29486795/the-first-in-class-alkylating-deacetylase-inhibitor-molecule-tinostamustine-shows-antitumor-effects-and-is-synergistic-with-radiotherapy-in-preclinical-models-of-glioblastoma
#19
Claudio Festuccia, Andrea Mancini, Alessandro Colapietro, Giovanni Luca Gravina, Flora Vitale, Francesco Marampon, Simona Delle Monache, Simona Pompili, Loredana Cristiano, Antonella Vetuschi, Vincenzo Tombolini, Yi Chen, Thomas Mehrling
BACKGROUND: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM). This regimen modestly prolongs overall survival, also if, in light of the still dismal prognosis, further improvements are desperately needed, especially in the patients with O6-methylguanine-DNA-methyltransferase (MGMT) unmethylated tumors, in which the benefit of standard treatment is less. Tinostamustine (EDO-S101) is a first-in-class alkylating deacetylase inhibitor (AK-DACi) molecule that fuses the DNA damaging effect of bendamustine with the fully functional pan-histone deacetylase (HDAC) inhibitor, vorinostat, in a completely new chemical entity...
February 27, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29477269/quality-of-life-behaviour-and-attitudes-towards-actinic-keratosis-in-spain-the-piqa-study
#20
I Longo, C Serra-Guillén
OBJECTIVE: This study was aimed to examine patients' knowledge, behaviours and attitudes regarding actinic keratosis (AK) lesions and the impact of the disease on patients' quality of life (QoL). METHODS: Observational study of patients with AK lesions in Spain. QoL was evaluated with the validated version of Spanish AKQoL questionnaire. Skin self-examination, sun-exposure, habits and attitudes towards AK's treatment were recorded using different questionnaires...
February 21, 2018: Actas Dermo-sifiliográficas
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