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https://www.readbyqxmd.com/read/28711897/studying-risk-factors-for-skin-cancer-development
#1
Оlena О Оshyvalova
INTRODUCTION: In most countries with a population of mainly European origin, non-melanoma skin carcinoma incidence rate has increased over the last decade. Understanding of what is the best way to identify people at high risk for skin cancer development will help to optimize the strategy for prevention and treatment tactics. Aim of the research involves studying risk factors for skin cancer development in patients with cutaneous squamous cell carcinoma and squamous cell carcinoma in situ (cSCC and SCCis correspondingly) and patients with actinic keratosis (AK)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28709990/in-vitro-development-of-an-effective-treatment-for-acanthamoeba-keratitis
#2
A Ortillés, J Belloc, E Rubio, M T Fernández, M Benito, J A Cristóbal, B Calvo, P Goñi
The aim of this study was to develop an in-vitro topical treatment for acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Riboflavin with ultraviolet-A (R+UV-A) as monotherapy or combined with voriconazole and moxifloxacin was also tested. Quantitative assays to assess cyst viability after treatment were performed for the chemicals that showed the highest activity in the qualitative assays...
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28707894/vitamin-d-receptor-regulates-amyloid-beta-1-42-production-with-protein-disulfide-isomerase-a3
#3
Duygu Gezen-Ak, Irem L Atasoy, Esin Candas, Merve Alaylioglu, Selma Yilmazer, Erdinc Dursun
The challenge of understanding the biology of neuronal amyloid processing could provide a basis for understanding the amyloid pathology in Alzheimer's disease (AD). Based on our previous studies we have suggested that AD might be the consequence of a hormonal imbalance in which the critical hormone is vitamin D. The present study primarily focused on the creation of a condition that prevents the genomic or non-genomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Aβ) production in primary cortical neurons were observed...
July 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28703320/5-aminolevulinic-acid-patch-pdt-in-the-treatment-of-actinic-cheilitis
#4
Sonja Radakovic, Adrian Tanew
BACKGROUND: Actinic cheilitis (AC) is a common disease caused by chronic ultraviolet exposure. OBJECTIVE: Alacare is a self-adhesive, skin coloured 5-aminolaevulinic acid (ALA) patch that has been developed for the treatment of mild to moderate actinic keratosis (AK). Considering the good results in the treatment of AK, the standardized delivery of ALA and the simple application Alacare patch PDT appears as an interesting treatment option for AC. METHODS: We retrospectively assessed the efficacy, tolerability and cosmetic outcome of Alacare patch PDT in eleven patients with AC...
July 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28692931/automatic-discrimination-of-actinic-keratoses-from-clinical-photographs
#5
Panagiota Spyridonos, Georgios Gaitanis, Aristidis Likas, Ioannis D Bassukas
BACKGROUND AND OBJECTIVE: Actinic keratoses (AK) are common premalignant skin lesions that can progress to invasive skin squamous cell carcinoma (sSCC). The subtle accumulation of multiple AK in aging individuals increases the risk of sSCC development, and this underscores the need for efficient treatment and patient follow-up. Our objectives were to develop a method based on color texture analysis of standard clinical photographs for the discrimination of AK from healthy skin and subsequently to test the developed approach in the quantification of field-directed treatment interventions...
July 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28689095/first-dual-ak-gsk-3%C3%AE-inhibitors-endowed-with-antioxidant-properties-as-multifunctional-potential-neuroprotective-agents
#6
Simone Brogi, Anna Ramunno, Lida Savi, Giulia Chemi, Gloria Alfano, Alessandra Pecorelli, Erika Pambianchi, Paola Galatello, Giulia Compagnoni, Federico Focher, Giuseppe Biamonti, Giuseppe Valacchi, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Margherita Brindisi
The manuscript deals with the design, synthesis and biological evaluation of novel benzoxazinone-based and indole-based compounds as multifunctional neuroprotective agents. These compounds inhibit human adenosine kinase (hAK) and human glycogen synthase kinase 3 beta (hGSK-3β) enzymes. Computational analysis based on a molecular docking approach underlined the potential structural requirements for simultaneously targeting both proteins' allosteric sites. In silico hints drove the synthesis of appropriately decorated benzoxazinones and indoles (5a-s, and 6a-c) and biochemical analysis revealed their behavior as allosteric inhibitors of hGSK-3β...
June 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28662116/actinic-keratosis-modelling-in-mice-a-translational-study
#7
Arnaud Pillon, Bruno Gomes, Isabelle Vandenberghe, Valérie Cartron, Patrick Cèbe, Jean-Christophe Blanchet, Vincent Sibaud, Nicolas Guilbaud, Laurent Audoly, Laurence Lamant, Anna Kruczynski
BACKGROUND: Actinic keratoses (AK) are pre-malignant cutaneous lesions caused by prolonged exposure to ultraviolet radiation. As AKs lesions are generally accepted to be the initial lesions in a disease continuum that progresses to squamous cell carcinoma (SCC), AK lesions have to be treated. They are also the second most common reason for visits to the dermatologist. Several treatments are available but their efficacy still needs to be improved. The UV-B-induced KA lesion mouse model is used in preclinical studies to assess the efficacy of novel molecules, even though it is often more representative of advanced AK or SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28661262/memantine-improves-semantic-memory-in-patients-with-amnestic-mild-cognitive-impairment-a-single-photon-emission-computed-tomography-study
#8
Demet Ilhan Algin, Suna Dagli Atalay, Serhat Ozkan, Demet Ozbabalik Adapinar, Ilknur Ak Sivrioz
Objective This study was performed to assess the efficacy of memantine in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty healthy controls and 45 patients diagnosed with aMCI based on the Petersen criteria were classified into 3 groups. Group 1 comprised patients who received a single memantine dose following examination (n = 25), Group 2 comprised patients who did not receive memantine treatment following examination (n = 20), and Group 3 comprised healthy age-matched volunteers (n = 30)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28658998/patient-reported-outcomes-in-topical-field-treatment-of-actinic-keratosis-in-swedish-and-danish-patients
#9
Hanna Norrlid, Jenny M Norlin, Heidi Holmstrup, Irena Malmberg, Karin Sartorius, Henrik Thormann, Gregor B E Jemec, Gunnel Ragnarson Tennvall
Topical treatments in dermatology can be long, complex and lead to nonadherence and nonpersistence to prescribed treatment. Clinical efficacy observed in randomized clinical trials (RCT) may therefore be reduced in real-world clinical practice. The objective of this study was to analyze patient-reported treatment adherence, treatment satisfaction and health-related quality of life (HRQoL) with topical treatments of actinic keratosis (AK) in routine clinical practice in Denmark and Sweden. Adult patients prescribed field-directed topical AK treatments with diclofenac gel, imiquimod or ingenol mebutate per routine clinical practice were eligible for the observational RAPID-ACT study...
June 29, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28656282/aqp3-small-interfering-rna-and-pld2-small-interfering-rna-inhibit-the-proliferation-and-promote-the-apoptosis-of-squamous-cell-carcinoma
#10
Xiaoyong Wang, Chengjun Tao, Chengda Yuan, Jinping Ren, Ming Yang, Hangyu Ying
Aquaporin 3 (AQP3) and phospholipase D2 (PLD2) are abnormally expressed and/or localized in squamous cell carcinoma (SCC). AQP3 transports glycerol to PLD2 for the synthesis of lipid second messenger, which can mediate the effect of the AQP3/PLD2 signaling module in the regulation of keratinocyte proliferation and differentiation. However, the role of the AQP3/PLD2 signaling module in the pathogenesis of SCC remains to be fully elucidated. In the present study, the expression levels of AQP3 and PLD2 in tissue samples were examined using immunohistochemistry, it was found that the expression levels of AQP3 and PLD2 in tissue samples of actinic keratosis (AK), Bowen's disease (BD) and SCC were significantly increased...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28656012/pathobiology-and-immunobiology-of-acanthamoeba-keratitis-insights-from-animal-models%C3%A2
#11
REVIEW
Sudha Neelam, Jerry Y Niederkorn
Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease...
June 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28638810/common-malignant-cutaneous-conditions-among-albinos-in-kenya
#12
Seyed Emad Emadi, Andrew Juma Suleh, Farhang Babamahmoodi, Fatemeh Ahangarkani, Vanessa Betty Chelimo, Beatrice Mutai, Seyyed Reza Raeeskarami, Alireza Ghanadan, Seyed Naser Emadi
Background: Albinos in Africa are at constant risk of developing skin cancer due to the damage caused by ultra-violet exposure. This study identifies the common skin conditions among albinos in Kenya as a country located along the equator. Methods: In this descriptive study on albino patients who were admitted to Mbagathi District Hospital in Nairobi, Kenya the census method was used for sampling and a total of 151 albinos were registered. All necessary data including age, gender, type, site and the number of skin lesions were recorded...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28628679/safety-and-efficacy-of-escalating-doses-of-ingenol-mebutate-for-field-treatment-of-actinic-keratosis-on-the-full-face-full-balding-scalp-or-chest
#13
C William Hanke, Brian Berman, Neil Swanson, David M Pariser, Jonathan S Weiss, Michael Bukhalo, Torsten Skov, John Villumsen, Daniel Siegel
<p>Background: Actinic keratosis (AK) can affect large skin areas. Ingenol mebutate (IngMeb) gel (0.015% and 0.05%) is approved for topical treatment of AK in a single contiguous area of ~25 cm2.</p> <p>Objective: The study sought to determine the maximum tolerated dose (MTD), efficacy, and tolerability of IngMeb applied to AK on a contiguous area less than equal to 250 cm2.</p> <p>Methods: Part 1 determined the MTD of IngMeb at 7 concentrations for 2 or 3 days. Part 2 assessed efficacy and tolerability at the MTD and one dose lower for 2 or 3 days vs vehicle...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28628678/assessment-of-efficacy-and-irritation-of-ingenol-mebutate-gel-0-015-used-with-or-without-dimethicone-lotion-for-treatment-of-actinic-keratosis-on-the-face
#14
Shelbi C Jim On, Peter W Hashim, John K Nia, Mark G Lebwohl
<p>Background: Ingenol mebutate gel 0.015% provides high clearance rates for actinic keratosis (AK) on the face and scalp but causes transient local skin responses (LSRs).</p> <p>Objective: This study sought to determine whether the application of 1% dimethicone would decrease ingenol mebutate-associated LSRs and/or affect efficacy during the treatment of multiple AKs on the face.</p> <p>Methods: Ingenol mebutate gel 0.015% was applied for 3 days to two 25 cm2 areas, each containing 3 to 8 AKs on the face of each subject, followed by application of 1% dimethicone lotion in an investigator-blinded manner to one randomly selected AK-containing area until LSRs were no longer present...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28615297/disruption-of-aneuploidy-and-senescence-induced-by-aurora-inhibition-promotes-intrinsic-apoptosis-in-double-hit-or-double-expressor-diffuse-large-b-cell-lymphomas
#15
Daruka Mahadevan, Shariful Islam, Wenqing Qi, Carla Morales, Laurence Cooke, Catherine Spier, Eric Weterings
Double Hit (DH) or Double Expressor (DE) diffuse large B-cell lymphoma (DLBCL) are aggressive Non-Hodgkin's Lymphomas (NHLs) with translocations and/or over-expressions of MYC and BCL-2, that are difficult to treat. Aurora kinase (AK) inhibition with alisertib in DH/DE-DLBCL induces cell death in ~30%, while ~70% are aneuploid and senescent cells (AASCs), a mitotic escape mechanism contributing to drug resistance. These AASCs elaborated a high metabolic rate by increased AKT/mTOR and ERK/MAPK activity via BTK signaling through the chronic active B-cell receptor (BCR) pathway...
June 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28614044/validation-of-odour-concentration-from-mbt-piles-using-static-chamber-and-wind-tunnel-with-the-different-wind-speed-values
#16
Mirosław Szyłak-Szydłowski
The basic principle of odour sampling from surface sources is based primarily on the amount of air obtained from a specific area of the ground, which acts as a source of malodourous compounds. Wind tunnels and flux chambers are often the only available, direct method of evaluating the odour fluxes from small area sources. There are currently no widely accepted chamber-based methods, thus there is still a need for standardization of them to ensure accuracy and comparability. Previous research has established that there is a significant difference between the odour concentration values obtained using the Lindvall chamber and those obtained by a dynamic flow chamber...
June 14, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28580871/pharmacoeconomic-evaluations-in-the-treatment-of-actinic-keratoses
#17
Keith Tolley, Giuseppe Argenziano, Pier Giacomo Calzavara-Pinton, Thomas Larsson, Lasse Ryttig
Actinic keratoses (AKs) develop as a consequence of chronic ultraviolet (UV) exposure and exist on a continuum with squamous cell carcinoma (SCC). As one of the most common conditions treated by dermatologists, AK places a significant burden on patients and the healthcare system. A range of treatments are used, including topical treatments that target the visible and subclinical lesions. The goal of such therapies is to achieve complete clearance of AKs and eliminate the risk of progression to SCC. Robust meta-analyses of trial data can provide valuable information for the optimal management of AK and cost-effectiveness evaluations of topical treatments, such as ingenol mebutate gel and diclofenac...
June 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28578540/application-of-chemometric-techniques-in-studies-of-toxicity-of-selected-commercially-available-products-for-infants-and-children
#18
Natalia Szczepańska, Błażej Kudłak, Miroslava Nedyalkova, Vasil Simeonov, Jacek Namieśnik
The goal of the present study is to assess the impact of the experimental conditions for extraction procedures (time of extraction, thermal treatment and type of extraction media) as applied to several baby and infant products checked for their possible ecotoxicological response when tested by various ecotoxicity tests (Microtox(®), Ostracodtoxkit F™ and Xenoscreen YES/YAS™). The systems under consideration are multidimensional by nature and, therefore, the appropriate assessment approach was intelligent data analysis (chemometrics)...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28562434/treatment-of-actinic-keratoses-a-randomized-split-site-approach-comparison-of-sequential-5-fluorouracil-and-5-aminolevulinic-acid-photodynamic-therapy-to-5-aminolevulinic-acid-photodynamic-monotherapy
#19
Susan Pei, Edidiong C N Kaminska, Maria M Tsoukas
BACKGROUND: Actinic keratoses (AKs) are skin lesions resulting from sun exposure and carry a risk of developing into squamous cell carcinoma. Current therapies for AK eradication include topical 5-fluorouracil (5-FU) and photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA). However, sequential therapy with 5-FU-ALA-PDT may offer improved outcome compared to ALA-PDT alone. OBJECTIVE: The purpose of this study is to compare the long-term efficacy of AK clearance by sequential therapy with 5-FU-ALA-PDT versus ALA-PDT alone...
May 25, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28557433/ligand-mediated-and-enzyme-directed-precise-targeting-and-retention-for-the-enhanced-treatment-of-glioblastoma
#20
Shaobo Ruan, Wei Xiao, Chuan Hu, Huajin Zhang, Jingdong Rao, Sihan Wang, Xiao Wang, Qin He, Huile Gao
Glioblastoma (GBM), one of the most lethal cancers, remains as a hard task to handle. The major hurdle of nanostructured therapeutic agents comes from the limited retention at the GBM site and poor selectivity. In this study, we reported dual-functional gold nanoparticles (AuNPs) to figure out the biological barrier and improve their accumulation in GBM. The nanoparticles, AuNP-A&C-R, were composed of two functional particles: one was Ala-Ala-Asn-Cys-Asp (AK) and R8-RGD-comodified AuNPs (AuNP-AK-R) and the other was 2-cyano-6-amino-benzothiazole and R8-RGD-comodified AuNPs (AuNP-CABT-R)...
June 21, 2017: ACS Applied Materials & Interfaces
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