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https://www.readbyqxmd.com/read/28222225/daylight-photodynamic-therapy-vs-conventional-photodynamic-therapy-as-skin-cancer-preventive-treatment-in-patients-with-face-and-scalp-cancerization-an-intra-individual-comparison-study
#1
Elena Sotiriou, Demetrios Ioannides, Fotini Vrani, Elizabeth Lazaridou, Efstratios Vakirlis, Aimilios Lallas, Zoe Apalla
BACKGROUND: Individuals with medical history of non-melanoma skin cancers (NMSCs) usually develop multiple and/or recurrent malignant lesions around the site of the primary neoplasm. The latter represents the clinical expression of the "field cancerization" theory; supporting the presence of multiple malignant clones of dysplastic keratinocytes over the entire epithelium that potentially can progress into clinical lesions. Taking into consideration that the burden of NMSCs on public health and health-care cost is high, adequate control of recurrences and management of field change is challenging...
February 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28177777/high-concentration-calcitriol-induces-endoplasmic-reticulum-stress-related-gene-profile-in-breast-cancer-cells
#2
Ali Burak Ozkaya, Handan Ak, Hikmet Hakan Aydin
Calcitriol, the active form of vitamin D, is known for its anti-cancer properties including induction of apoptosis, inhibition of angiogenesis and metastasis. Understanding the mechanism of action for calcitriol will help development of novel treatment strategies. Since vitamin D exerts its cellular actions via binding to its receptor and by altering expressions of a set of genes, we aimed to evaluate the effect of calcitriol on transcriptomic profile of breast cancer cells. We previously demonstrated that calcitriol alters ER stress markers, therefore in this study we have focused on ER-stress related genes to reveal calcitriols action on these genes in particular...
June 29, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28167201/efficacy-of-iontophoresis-assisted-ablative-fractional-laser-photodynamic-therapy-with-short-incubation-time-for-the-treatment-of-actinic-keratosis-12-month-follow-up-results-of-a-prospective-randomised-comparative-trial
#3
Seung-Hwan Choi, Tae-Hoon Kim, Ki-Hoon Song
BACKGROUND: Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed photodynamic therapy (AFL-PDT). The aim of this study were to compare the efficacy, recurrence rate, cosmetic outcome and safety of iontophoresis-assisted AFL-PDT with 2hours of incubation vs. those of conventional AFL-PDT with 2- and 3-hour incubation in patients with facial and scalp AK...
February 3, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28124962/-investigation-of-the-in-vitro-effects-of-melissa-officinalis-l-mentha-x-piperita-l-and-ocimum-basilicum-l-lamiaceae-essential-oils-on-the-cysts-and-trophozoites-of-acanthamoeba-castellani
#4
Ceren Ergüden, Soykan Özkoç, Bintuğ Öztürk, Songül Bayram Delibaş
Acanthamoeba species are free living amoeba found widely all over the world. They are responsible for Acanthamoeba keratitis (AK), an infection which is especially seen in contact lens users and after minor corneal traumas, that may lead blindness. At present, antifungals and antiseptics are used for the treatment of AK cases, however, some problems such as long treatment periods and the occurrence of side effects, resistance of cyst forms against drugs, emphasize the need for new drugs. There are some published studies that pointed out the effectiveness of plant extracts and essential oils on Acanthamoeba spp...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28118830/the-economic-burden-of-hiv-aids-on-individuals-and-households-in-nepal-a-quantitative-study
#5
Ak Narayan Poudel, David Newlands, Padam Simkhada
BACKGROUND: There have been only limited studies assessing the economic burden of HIV/AIDS in terms of direct costs, and there has been no published study related to productivity costs in Nepal. Therefore, this study explores in detail the economic burden of HIV/AIDS, including direct costs and productivity costs. This paper focuses on the direct costs of seeking treatment, productivity costs, and related factors affecting direct costs, and productivity costs. METHODS: This study was a cross-sectional, quantitative study...
January 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28116535/investigation-of-photobiomodulation-potentiality-by-635-and-809%C3%A2-nm-lasers-on-human-osteoblasts
#6
Gamze Bölükbaşı Ateş, Ayşe Ak Can, Murat Gülsoy
Photobiomodulation (PBM) describes light-induced photochemical reactions achieved by the application of red or near infrared lasers/LED light with low energy densities. This noninvasive and painless method has been used in some clinical areas but controversial outcomes demand a skeptical look for its promising and potential effects. In this detailed in vitro study, the osteoblast cells were irradiated with 635 and 809 nm diode lasers at energy densities of 0.5, 1, and 2 J/cm(2). Cell viability, proliferation, bone formation, and osteoblast differentiation were evaluated by methylthiazole tetrazolium (MTT) assay, Alamar Blue assay, acridine orange/propidium iodide staining, alkaline phosphatase (ALP) activity, Alizarin red staining, and reverse-transcription polymerase chain reaction (RT-PCR) to test the expression of collagen type I, ALPL, and osteocalcin...
January 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28114674/influence-of-information-framing-on-patient-decisions-to-treat-actinic-keratosis
#7
Katherine Berry, Melissa Butt, Joslyn S Kirby
Importance: Actinic keratosis (AK) is a skin growth induced by UV light exposure that requires long-term management because a small proportion of the disease can progress to squamous cell carcinoma. The influence of how clinicians frame or present information to patients may affect decision making about AK. Objective: To evaluate the differences in patients' decisions on whether to receive treatment for AK related to information presentation or choice framing. Design, Setting, and Participants: A prospective survey study was performed from June 1 to July 31, 2016, in participants who were able to read English...
January 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28101017/efficacy-of-a-film-forming-medical-device-containing-piroxicam-and-sun-filters-in-the-treatment-of-multiple-actinic-keratosis-lesions-in-a-subject-with-a-history-of-kaposi-sarcoma
#8
Elisabetta Scotti, Salvatore Deledda, Massimo Milani
Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Data regarding the involvement of other viruses, i.e. human herpes viruses (HHV), in the pathogenesis of AK are so far controversial...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#9
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095373/comparison-of-lesion-by-lesion-and-field-photodynamic-therapy-in-the-prevention-of-actinic-keratoses-a-randomized-split-face-single-blind-pilot-study
#10
Inge Seubring, Joannes M M Groenewoud, Marie-Jeanne P Gerritsen
BACKGROUND: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. OBJECTIVE: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT)...
January 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#11
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28079686/number-of-bacteria-and-time-of-coincubation-with-bacteria-required-for-the-development-of-acanthamoeba-keratitis
#12
Hayate Nakagawa, Takaaki Hattori, Naohito Koike, Tomoko Ehara, Akitomo Narimatsu, Shigeto Kumakura, Tetsuya Matsumoto, Hiroshi Goto
PURPOSE: We hypothesized that bacteria may be a factor contributing to the development of Acanthamoeba keratitis (AK). We investigated interactions between Acanthamoeba and Pseudomonas aeruginosa for the development of keratitis in rabbit corneas. METHODS: Acanthamoeba castellanii (ATCC50492) and P. aeruginosa (PAO-1) were used. Two densities of P. aeruginosa (high, 1 × 10/mL; low, 3 × 10/mL) and 2 durations of coincubation (long, 6 h; short, 2 h) of Acanthamoeba with 1 × 10/mL of P...
March 2017: Cornea
https://www.readbyqxmd.com/read/28078678/a-seamless-phase-i-ii-dose-finding-trial-assessing-ingenol-disoxate-leo-43204-for-field-treatment-of-actinic-keratosis-on-the-scalp
#13
J Weiss, M Ulrich, M Bukhalo, M L Østerdal, B Bang, C W Hanke
BACKGROUND: Actinic keratosis (AK) is a common sun-related skin condition, which can progress to squamous cell carcinoma and occur in cancerised fields. OBJECTIVES: This Phase I/II trial investigated the safety and efficacy of ingenol disoxate as topical field therapy for patients with AK on the balding scalp. METHODS: Part 1 was a Phase I, open-label, dose-escalation trial investigating up to 6 doses of ingenol disoxate to determine the maximum tolerated dose (MTD)...
January 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28074457/the-acute-effects-of-thymoquinone-on-acute-peripheral-nerve-injury-an-experimental-study
#14
İsmail Gülşen, Hakan Ak, Mikail Kara, Abdulsemat Gökalp, Veysel Akyol, Ömer Faruk Koçak, Murat Çetin Rağbetli
BACKGROUND: The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury. METHODS: A rat model of crush injury of the sciatic nerve was used. Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group). Seven days after injury, sciatic nerve specimens were obtained from the site of the injury and analyzed histologically and stereologically. Axon diameter, myelin thickness, and axon density were measured...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28053616/sirtuin-2-inhibition-affects-hippocampal-functions-and-sodium-butyrate-ameliorates-the-reduction-in-novel-object-memory-cell-proliferation-and-neuroblast-differentiation
#15
Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Dae Won Kim, Jung Hoon Choi, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwang
We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships with sodium butyrate, a histone deacetylase inhibitor, on the hippocampal functions. To investigate the effects of AK-7 on hippocampal functions, 10-week-old C57BL/6 mice were daily injected intraperitoneally with 20 mg/kg AK-7 alone or in combination with subcutaneous administration of 300 mg/kg sodium butyrate, a histone deacetylase inhibitor, for 21 days...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28012181/randomized-controlled-trial-comparing-35-trichloroacetic-acid-peel-and-5-aminolevulinic-acid-photodynamic-therapy-for-the-treatment-of-multiple-actinic-keratosis
#16
G Holzer, A Pinkowicz, S Radakovic, J B Schmidt, A Tanew
BACKGROUND: Photodynamic therapy (PDT) and chemical peels with trichloroacetic acid (TCA) can be applied to larger skin areas and thus are suitable treatment options for patients with multiple actinic keratosis (AK). Despite its long use TCA has, however, only been investigated rarely in this indication. OBJECTIVES: This randomized, observer-blinded, intrapatient comparison study sought to investigate the efficacy and safety of 35% TCA versus 20% aminolevulinic acid PDT (ALA PDT) in patients with extensive field cancerisation and multiple AK in the face or on the scalp...
December 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/28008278/acne-keloidalis-nuchae-prevalence-impact-and-management-challenges
#17
REVIEW
Adebola Ogunbiyi
Acne keloidalis nuchae (AKN) also known as folliculitis keloidalis nuchae (FKN) is a chronic form of scarring folliculitis seen mostly in men of African descent. The term AKN is commonly used even though the condition is not a keloid, and the affected individuals do not have a tendency to develop keloids in other areas of the body. It is seen in post pubertal men and is rare after the age of 55 years. A few cases have been reported in females. which has been classified as a primary cicatricial alopecia since the exact cause of acne keloidalis (AK) remains unknown...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28007674/the-current-role-of-in-vivo-reflectance-confocal-microscopy-within-the-continuum-of-actinic-keratosis-and-squamous-cell-carcinoma-a-systematic-review
#18
Kim P Nguyen, Malou Peppelman, Lisa Hoogedoorn, Piet E J Van Erp, Marie-Jeanne P Gerritsen
BACKGROUND: Clinical differentiation between actinic keratosis (AK), squamous cell carcinoma (SCC) in situ, and invasive SCC and its variants may be difficult. Reflectance confocal microscopy (RCM) is a non-invasive technique for in vivo skin imaging. OBJECTIVES: To explicate the diagnostic and monitoring use of RCM within the spectrum of AK and SCC, and evaluate the accuracy of RCM for these diagnoses relative to histopathology. MATERIALS & METHODS: A systematic literature search was performed in PubMed, EMBASE, the Cochrane Library, and Web of Science databases...
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28002105/variables-in-cryosurgery-technique-associated-with-clearance-of-actinic-keratosis
#19
Brian Berman, Arsalan Qazi Shabbir, Tanya MacNeil, Kim Mark Knudsen
BACKGROUND: Cryosurgery is the most commonly used method to treat actinic keratosis (AK). Cryosurgical methods are not standardized. OBJECTIVE: To examine differences in the spray techniques used for liquid nitrogen cryosurgery when treating AKs of the head, and the effect of these variations in technique on rates of complete clearance of AKs. MATERIALS AND METHODS: Patients were those from the FIELD-1 study, who received cryosurgery as per the investigators' usual practice to all AKs...
December 19, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27995485/efficacy-and-safety-of-5-fluorouracil-0-5-salicylic-acid-10-in-the-field-directed-treatment-of-actinic-keratosis-a-phase-iii-randomized-double-blind-vehicle-controlled-trial
#20
Eggert Stockfleth, Ralph von Kiedrowski, Rolf Dominicus, John Ryan, Adam Ellery, Meritxell Falqués, Nathalie Ivanoff, Rosario Rodriguez Azeredo
INTRODUCTION: Due to the high prevalence of actinic keratosis (AK) and potential for lesions to become cancerous, clinical guidelines recommend that all are treated. The objective of this study was to evaluate the efficacy and safety of 5-fluorouracil (5-FU) 0.5%/salicylic acid 10% as field-directed treatment of AK lesions. METHODS: This multicenter, double-blind, vehicle-controlled study (NCT02289768) randomized adults, with a 25 cm(2) area of skin on their face, bald scalp, or forehead covering 4-10 clinically confirmed AK lesions (grade I/II), 2:1 to treatment or vehicle applied topically once daily for 12 weeks...
December 19, 2016: Dermatology and Therapy
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