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JOURNAL ARTICLE
Bo Liu, Hao Xia, Chaoqiang Jiang, Cuncang Jiang, Muhammad Riaz, Li Yang, Yunfeng Chen, Xianpeng Fan, Zhiyi Zhang, Xiaoli Duan, Maoqian Wu, Xiange Xia
Straw return utilizes waste resources to reduce the use of chemical fertilizers worldwide. However, information is still lacking on the relative impact of straw return on soil fertility, the nutrient composition of different soil aggregates, and soil microbial communities. Therefore, this study aimed to understand the effects of different management practices on the crop yield, soil fertility, and soil community composition in a 14-year wheat-rice rotation system. The treatments included a control (without fertilizer and straw addition), chemical fertilization (NPK), straw return without fertilizer (S), and straw addition with chemical fertilizer (NPKS)...
March 29, 2024: Plants (Basel, Switzerland)
#22
JOURNAL ARTICLE
Vinzent Kevin Ortner, Kim Kilov, Alejandro Castillo Mondragón, Gabriella Fredman, Silje Haukali Omland, Ionela Manole, Charlotte Amalie Pind Laugesen, Signe Havsager, Berit Johansen, Tore Duvold, Ari Páll Isberg, Anders Daniel Andersen, John R Zibert, Merete Hædersdal
Hybrid trials are a new trend in dermatological research that leverage mobile health technologies to decentralize a subset of clinical trial elements and thereby reduce the number of in-clinic visits. In a Phase I/IIa randomized controlled hybrid trial, the safety and efficacy of an anti-proliferative and anti-inflammatory drug inhibiting cytosolic phospholipase A2 (AVX001) was tested using 1%, 3% or vehicle gel in 60 patients with actinic keratosis (AK) and assessed in-clinic as well as remotely. Over the course of 12 weeks, patients were assessed in-clinic at baseline, end of treatment (EOT) and end of study (EOS), as well as 9 times remotely on a weekly to biweekly basis...
April 2024: Experimental Dermatology
#23
JOURNAL ARTICLE
Chenyu Yang, Xiaomin Li, Yun Deng, Weiqiang Qiu, Lanming Chen, Li Li, Ashily Liang Wang, Yuhui Feng, Yingshan Jin, Ningping Tao, Feng Li, Yinzhe Jin
To evaluate the effect of high voltage pulsed electric field (PEF) treatment (10-20 kV/cm, 5-15 min) on the structural characteristics and sensitization of crude extracts of arginine kinase from Fenneropenaeus chinensis. By simulated in vitro gastric juice digestion (SGF), intestinal juice digestion (SIF) and enzyme-linked immunosorbent assay (ELISA), AK sensitization was reduced by 42.5% when treated for 10 min at an electric field intensity of 15 kV/cm. After PEF treatment, the α-helix content decreased, and the α-helix content gradually changed to β-sheet and β-turn...
April 9, 2024: Food Chemistry
#24
JOURNAL ARTICLE
Ivan Cherrez-Ojeda, Jean Bousquet, Ana Giménez-Arnau, Kiran Godse, Dorota Krasowska, Joanna Bartosińska, Paulina Szczepanik-Kułak, Bartłomiej Wawrzycki, Pavel Kolkhir, Anastasiia Allenova, Andrey Allenov, Sergey Tkachenko, Natasa Teovska Mitrevska, Dragan Mijakoski, Sasho Stoleski, Marta Kolacinska-Flont, Izabela Kuprys-Lipinska, Joanna Molinska, Alicja Kasperska-Zając, Magdalena Zajac, Mateusz Zamlynski, Florin Mihaltan, Ruxandra Ulmeanu, Anna Zalewska-Janowska, Katarzyna Tomaszewska, Mona Al-Ahmad, Maryam Ali Al-Nesf, Tayseer Ibrahim, Sami Aqel, David Pesqué, Mónica Rodríguez-González, Guillermo Hideo Wakida-Kuzunoki, German D Ramon, Gonzalo N Ramon, Sophia Neisinger, Hanna Bonnekoh, Maia Rukhadze, Maryam Khoshkhui, Daria Fomina, Désirée Larenas-Linnemann, Mitja Košnik, Rabia Oztas Kara, Chrystopherson Gengyny Caballero López, Qiang Liu, Carlos Ivancevich Juan, Luis Felipe Ensina, Nelson Rosario, Violeta Kvedariene, Moshe Ben-Shoshan, Roberta Fachini Jardim Criado, Andrea Bauer, Annia Cherrez, Herberto Chong-Neto, Maria Isabel Rojo-Gutierrez, Michael Rudenko, José Ignacio Larco Sousa, Aleksandra Lesiak, Edgar Matos, Nelson Muñoz, Ivan Tinoco, Jaime Moreno, Carolina Crespo Shijin, Romina Hinostroza Logroño, Juan C Sagñay, Marco Faytong-Haro, Karla Robles-Velasco, Torsten Zuberbier, Marcus Maurer
BACKGROUND: Patient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations and guide treatment decisions. PROMs are crucial for monitoring atopic dermatitis (AD) and chronic urticaria (CU) in clinical practice, but there are unmet needs and knowledge gaps regarding their use in clinical practice. OBJECTIVE: We investigated the global real-world use of AD and CU PROMs in allergology and dermatology clinics as well as their associated local and regional networks...
April 9, 2024: Journal of Allergy and Clinical Immunology in Practice
#25
JOURNAL ARTICLE
Leila Masoori, Amal Khudair Khalaf, Fatemeh Ezatkhah, Rafael Balaña-Fouce, Hossein Mahmoudvand
Reportedly, synthetic drugs such as metronidazole, furazolidone, tinidazole, and quinacrine are used for the treatment of giardiasis but are associated with adverse effects. In this study, we aimed to investigate the in vitro and in vivo effects of eucalyptol (ECT, 1,8 cineole) alone and in combination with metronidazole (MNZ) on Giardia lamblia. The effects of ECT on cell viability, plasma membrane permeability, and gene expression levels of adenylate cyclase (AK) and extracellular signal kinases 1 and 2 (ERK1 and ERK2) in trophozoites of G...
April 9, 2024: Acta Tropica
#26
JOURNAL ARTICLE
Xiaoguo Zhou, Yutong Hu, Huijun Li, Jiandong Sheng, Junhui Cheng, Tingting Zhao, Yuanmei Zhang
INTRODUCTION: Understanding the response of cross-domain co-occurrence networks of soil microorganisms to phosphorus stability and the resulting impacts is critical in ecosystems, but the underlying mechanism is unclear in artificial grassland ecosystems. METHODS: In this study, the effects of four phosphorus concentrations, P0 (0 kg P ha-1 ), P1 (15.3 kg P ha-1 ), P2 (30.6 kg P ha-1 ), and P3 (45.9 kg P ha-1 ), on the cross-domain co-occurrence network of bacteria and fungi were investigated in an artificial Leymus chinensis grassland in an arid region...
2024: Frontiers in Microbiology
#27
JOURNAL ARTICLE
Alice L Milligan, Jeremy J Hoffman, Yan Ning Neo, Su-Yin Koay
BACKGROUND: Laboratory confirmation is crucial for diagnosis and management of herpes simplex virus (HSV) keratitis. However, the sensitivity of polymerase chain reaction (PCR) in keratitis is low (25%) compared with that of mucocutaneous disease (75%). We developed an educational intervention aimed at improving the diagnostic yield of PCR. METHODS: The medical records of keratitis cases seen at the emergency department of a London tertiary ophthalmic referral hospital over two distinct periods, before and after an educational program on swab technique, were reviewed retrospectively...
2024: Digital Journal of Ophthalmology: DJO
#28
REVIEW
Bilal Hussain, Sanchit Duhan, Ahmed Mahmood, Luay Al-Alawi, Mian Muhammad Salman Aslam, Christel Cuevas, Thomas Alexander, Mohammad M Ansari, Fahad Waqar
INTRODUCTION: Pacemaker (PPM) implantation is indicated for conduction abnormalities which can develop post-transcatheter aortic valve replacement (TAVR). However, whether post-TAVR PPM risk is associated with the geographical location of the hospital and socioeconomic status of the patient is not well established. Our goal was to explore geographical and socioeconomic disparities in post-TAVR PPM implantation. METHODS: A retrospective cohort analysis was conducted using the National Inpatient Sample 2016-2020 with respective ICD-10 codes for TAVR and PPM implantation...
April 5, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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JOURNAL ARTICLE
Dorian G Luijkx, Asli Ak, Ge Guo, Clemens A van Blitterswijk, Stefan Giselbrecht, Erik J Vrij
Monochorionic twinning of human embryos increases the risk of complications during pregnancy. The rarity of such twinning events, combined with ethical constraints in human embryo research, makes investigating the mechanisms behind twinning practically infeasible. As a result, there is a significant knowledge gap regarding the origins and early phenotypic presentation of monochorionic twin embryos. In this study, a microthermoformed-based microwell screening platform is used to identify conditions that efficiently induce monochorionic twins in human stem cell-based blastocyst models, termed "twin blastoids"...
April 9, 2024: Advanced Materials
#30
REVIEW
Marcin Piechocki, Tadeusz Przewłocki, Piotr Pieniążek, Mariusz Trystuła, Jakub Podolec, Anna Kabłak-Ziembicka
Aging is a key risk factor for atherosclerosis progression that is associated with increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity, quality of life, and it is associated with reduced life expectancy. As most multicenter randomized trials exclude elderly and very elderly patients, particularly those with severe comorbidities, physical or cognitive dysfunctions, frailty, or residence in a nursing home, there is insufficient data on the management of older patients presenting with atherosclerotic lesions outside coronary territory...
March 5, 2024: Journal of Clinical Medicine
#31
REVIEW
Marcin Piechocki, Tadeusz Przewłocki, Piotr Pieniążek, Mariusz Trystuła, Jakub Podolec, Anna Kabłak-Ziembicka
Atherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for atherosclerosis progression that is associated with the increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity and quality of life, and it is associated with reduced life expectancy...
March 3, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Osman Başpınar, Mehmet Kervancıoğlu, Metin Kılınç, Derya Aydın Şahin, Münevver Tuğba Temel
OBJECTIVE: We aimed to evaluate the safety and efficacy of radiation dose reduction with a new-generation biplane angiocardiography system in patients undergoing transcatheter isolated patent ductus arteriosus (PDA) closure. MATERIALS AND METHODS: Fifty pediatric patients who underwent transcatheter PDA closure were randomly divided into two groups as normal radiation dose and low dose. Patients who required additional procedures other than PDA closure were excluded...
April 15, 2024: Heliyon
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JOURNAL ARTICLE
Sol Beccari, Esraa Mohamed, Viva Voong, Stephanie Hilz, Marisa Lafontaine, Anny Shai, Yunita Lim, Jerry Martinez, Benjamin Switzman, Ryon L Yu, Janine M Lupo, Eddie F Chang, Shawn L Hervey-Jumper, Mitchel S Berger, Joseph F Costello, Joanna J Phillips
Biomarker-driven therapeutic clinical trials require implementation of standardized, evidence-based practices for sample collection. In diffuse glioma, phosphatidylinositol 3 (PI3)-kinase/AKT/mTOR (PI3/AKT/mTOR) signaling is an attractive therapeutic target for which window of opportunity clinical trials could facilitate identification of promising new agents. Yet, the relevant preanalytic variables and optimal tumor sampling methods necessary to measure pathway activity are unknown. To address this, we used a murine model for IDH-wildtype glioblastoma (GBM) and human tumor tissue, including IDH-wildtype GBM and IDH-mutant diffuse glioma...
April 6, 2024: Modern Pathology
#34
JOURNAL ARTICLE
Hatice Ferhan Kömürcü, Eren Gözke, Irmak Salt, Işil Kalyoncu Aslan, Pelin Doğan Ak
Hemorrhagic complications may be seen following reperfusion therapy with rtPA and/or thrombectomy after acute ischemic stroke (AIS). Neutrophils, lymphocytes, and platelets have important roles in the inflammatory and immune responses that develop in these patients. We investigated time‑dependent changes in blood cells, NIHSS and mRS values according to type of reperfusion therapy in AIS patients who developed cerebral hemorrhage. In AIS patients who underwent rtPA and/or thrombectomy and developed cerebral hemorrhage within the first 24 hours after treatment, leukocyte, neutrophil, lymphocyte, platelet counts and their ratios were recorded on admission, 1st, 3rd, and 7th days...
March 28, 2024: Acta Neurobiologiae Experimentalis
#35
REVIEW
Zhiya Yang, Dongmei Li, Dongmei Shi
Skin tumors commonly seen in dermatology are involved in all layers of the skin and appendages. While biopsy of affected skin remains an essential method to confirm diagnosis and to predicate tumor prognosis, it has its limitations. Recently, photodynamic diagnosis (PDD) has demonstrated high sensitivity in detecting affected skin and mucosal tissues, providing valuable guidance for precision surgery to resect skin and mucosal tumors. In this review, we summarized the literatures concerning the applications of PDD in diagnostic process and treatment of skin and mucosal conditions such as actinic keratoses (AK), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen's disease (BD) and extramammary Paget's disease (EMPD)...
April 6, 2024: Current Treatment Options in Oncology
#36
JOURNAL ARTICLE
John Fang, Christian Fang, Andy Moyal, Enrico Ascher, Anil Hingorani, Natalie Marks
BACKGROUND: Polidocanol endovenous microfoam (PEM) has been used to treat lower extremity venous reflux for almost a decade with specific advantage in below knee (BK) truncal veins where thermal ablation poses a risk for injury to adjacent nerves. Current literature in the BK segment often examines short-term outcomes with modest sample sizes. We aim to identify factors associated with recanalization and reintervention in this subset of patients. METHODS: We performed a retrospective study of a prospectively maintained database of patients from a single institution who underwent PEM ablation for BK great saphenous vein (GSV) and small saphenous vein (SSV) reflux...
April 3, 2024: Journal of Vascular Surgery. Venous and Lymphatic Disorders
#37
JOURNAL ARTICLE
Venkataramana Kandi, Praveen R Shahapur, Tarun Kumar Suvvari, Vallab Ganesh Bharadwaj, Chitra Rajalakshmi P, Roopa Shahapur, Eswar Podaralla, Vikram Godishala
Introduction An enormous increase in antimicrobial resistance (AMR) among bacteria isolated from human clinical specimens contributed to treatment failures. Increased surveillance through next-generation sequencing (NGS) or whole genome sequencing (WGS) could facilitate the study of the epidemiology of drug-resistant bacterial strains, resistance genes, and other virulence determinants they are potentially carrying. Methods This study included 30 Escherichia coli ( E . coli ) isolates obtained from patients suffering from urinary tract infections (UTIs) attending Prathima Institute of Medical Sciences, Karimnagar, India...
March 2024: Curēus
#38
JOURNAL ARTICLE
Tuba Kayan Tapan, Filiz Çelebi, Kourosh Yaghouti, Filiz Ağaçayak, Serkan İlgün, Gürsel Soybir, Gül Alço, Naziye Ak, Çetin Ordu, Enver Özkurt, Çağlar Ünal, Sevgi Kurt, Alper Öztürk, Zeynep İyigün, Tomris Duymaz, Vahit Özmen
OBJECTIVE: Differences in individual muscle/fat volumes may change the effectiveness of chemotherapy. In this study, the relationship between trunkal muscle and fat volume and body mass index (BMI) obtained before receiving neoadjuvant chemotherapy (NCT) in patients with breast cancer and complete pathological response (pCR) was investigated. MATERIALS AND METHODS: The volumes of psoas, abdominal and paraspinal muscles, and trunkal subcutaneous and visceral fat were calculated using CoreSlicer AI 2...
April 2024: European Journal of Breast Health
#39
JOURNAL ARTICLE
Mathimaran Amala, Hemavathy Nagarajan, Mathimaran Ahila, Mutharasappan Nachiappan, Malaisamy Veerapandiyan, Umashankar Vetrivel, Jeyaraman Jeyakanthan
Aspartate kinase (AK), an enzyme from the Wolbachia endosymbiont of Brugia malayi (WBm), plays a pivotal role in the bacterial cell wall and amino acid biosynthesis, rendering it an attractive candidate for therapeutic intervention. Allosteric inhibition of aspartate kinase is a prevalent mode of regulation across microorganisms and plants, often modulated by end products such as lysine, threonine, methionine, or meso-diaminopimelate. The intricate and diverse nature of microbial allosteric regulation underscores the need for rigorous investigation...
April 1, 2024: International Journal of Biological Macromolecules
#40
JOURNAL ARTICLE
Akli Islem Chebli, Zeyneb Chelighem, Emad Shalabi, Younes Zebbiche, Nada Boubidi, Bahi Baraa, Nechoia Boumalha, Djihad Bouhlassa, Sara Abdennour
INTRODUCTION: Medication non-adherence is a global concern, particularly in the context of renal transplantation, where it leads to graft failures, increased hospitalizations, diminished quality of life for patients, and higher healthcare costs. The aim of this study was to assess the level of therapeutic adherence among Algerian kidney transplant recipients and identify potential influencing factors. METHODS: A descriptive, cross-sectional bicenter study was conducted among kidney transplant patients receiving outpatient care at two specialized medical centers in Algeria: the Urology Department of the Hospital Establishment for Urology, Nephrology, and Renal Transplantation in Constantine, and the Nephrology and Renal Transplantation Department of the University Hospital Center (CHU) in Blida, spanning from January to December 2022...
April 4, 2024: Néphrologie & Thérapeutique
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