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https://www.readbyqxmd.com/read/29346088/intense-olfactory-stimulation-blocks-seizures-in-an-experimental-model-of-epilepsy
#1
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK)...
January 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29339061/dose-dependent-photochemical-photothermal-toxicity-of-indocyanine-green-based-therapy-on-three-different-cancer-cell-lines
#2
Mustafa Kemal Ruhi, Ayşe Ak Can, Murat Gülsoy
The Food and Drug Administration-approved Indocyanine Green can be used as a photosensitizer to kill cancer cells selectively. Although indocyanine green is advantageous as a photosensitizer in terms of strong absorption in the near-infrared region, indocyanine green-based cancer treatment is still not approved as a clinical method. Some reasons for this are aggregation at high concentrations, rapid clearance of the photosensitizer from the body, low singlet oxygen quantum yield, and the uncertainty concerning its action mechanism...
January 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29334042/orbital-myositis-an-underrecognized-clinical-syndrome-with-a-need-of-management-guidelines
#3
Leyla Baysal Kirac, Arman Cakar, Yagmur Turkoglu, Hazal-Ceren Ak, Doga Coskun, Sibel Ustun-Ozek, Serap Uçler-Yaman, Betul Baykan
No abstract text is available yet for this article.
January 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29331035/noninvasive-optical-spectroscopy-for-identification-of-non-melanoma-skin-cancer-pilot-study
#4
David J Carpenter, Mirabelle B Sajisevi, Nikita Chapurin, Clifford Scott Brown, Tracy Cheng, Gregory M Palmer, Daniel S Stevenson, Caroline L Rao, Russell P Hall, Charles R Woodard
OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. For each skin lesion, provider pre-biopsy probability of malignancy was compared to histolopathologic diagnosis...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29329159/overexpression-of-the-long-noncoding-rna-homeboxa-transcript-at-the-distal-tip-predicts-poor-prognosis-in-a-kras-independent-manner-in-periampullary-region-tumors
#5
Ozkan Balcin, Secil Ak Aksoy, Berrin Tunca, Ekrem Kaya, Unal Egeli, Gulcin Tezcan, Nesrin Ugras, Gulsah Cecener, Ozgen Isik, Halit Ziya Dundar, Omer Yerci
OBJECTIVES: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29325742/mutation-of-the-conserved-g66-residue-in-gs-region-decreased-structural-stability-and-activity-of-arginine-kinase
#6
Qing-Yun Wu, Yuan-Yuan Zhu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Xiao-Yun Wang, Kai-Lin Xu
Arginine kinase (AK) catalyzes the reversible phosphorylation of arginine by ATP, yielding the phosphoarginine. Amino acid residues in the guanidine specificity (GS) region play important roles in the guanidine-recognition. However, little is known about roles of amino acid residue G66 in the GS region in proteins folding, activity and structural stability. In this study, a series of G66 mutations were constructed to investigate its roles in AK's structural stability and activity. Our studies revealed that mutations in this conserved site could cause pronounced loss of activity, conformational changes and structural stability...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29322431/daylight-photodynamic-therapy-versus-5-fluorouracil-for-the-treatment-of-actinic-keratosis-a-case-series
#7
Gaston Nestor Galimberti
INTRODUCTION: The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. METHODS: Five male subjects (mean age 70 years) with grade I-III AK on the face/scalp were enrolled...
January 10, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29314581/independent-and-mentored-video-review-of-osces
#8
Somnath Mookherjee, Jennie Strujik, Matthew Cunningham, Elizabeth Kaplan, Bas Ak Çoruh
BACKGROUND: Video review of OSCE (objective structured clinical examination) performance allows students to analyse their performance, identify actions and behaviours for correction or reinforcement, and develop a plan for improvement of clinical skills. Student perceptions of the utility of independent and mentored video review are unknown. METHODS: We created a pilot programme of post-OSCE structured video review. Students were randomised to mentored (M) or independent (I) review...
January 5, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29314400/caregivers-lived-experience-in-trying-to-read-slight-movements-in-a-child-with-severe-brain-injury-a-phenomenological-study
#9
Naoko Kameda, Machiko Suzuki
AIMS & OBJECTIVES: We explored caregivers' lived experience of reading slight movements of a child with severe brain injury. BACKGROUND: Despite increased need, the development of individual care for children with severe brain injuries has been prevented by their severe physical state and the poor reproducibility of their movements. In addition to a lack of evidence on the motor characteristics of patients with severe brain injury with multiple disabilities, their own development contributes to increasing variability in their states...
January 4, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29311041/5-fluorouracil-chemowraps-for-the-treatment-of-multiple-actinic-keratoses
#10
Lucie Peuvrel, Mélanie Saint-Jean, Gaëlle Quereux, Anabelle Brocard, Marie Le Moigne, Cécile Frénard, Amir Khammari, Brigitte Dreno
Few satisfactory treatment options are available for widespread areas affected by multiple actinic keratoses (AKs). Our primary objective was to assess the response rate to weekly 5-fluorouracil (5-FU) chemowraps on widespread AK lesions, and secondarily to assess tolerability, the percentage of patients with recurrence and time to recurrence, the response rate for patients with associated Bowen's disease (BD), and the percentage of squamous cell carcinomas (SCCs) identified after treatment. We conducted an open study which included all the patients who had been treated with weekly 5-FU chemowraps in our department over the course of five years for areas of widespread AKs...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29311040/prevalence-and-risk-factors-of-actinic-keratosis-in-patients-attending-italian-dermatology-clinics
#11
Maria Concetta Fargnoli, Gianfranco Altomare, Elisa Benati, Francesco Borgia, Paolo Broganelli, Anna Carbone, Sergio Chimenti, Sergio Donato, Giampiero Girolomoni, Giuseppe Micali, Erica Moggio, Aurora Parodi, Stefano Piaserico, Giuseppe Pistone, Concetta Potenza, Mario Puviani, Margherita Raucci, Sabina Vaccari, Stefano Veglio, Andrea Zanca, Ketty Peris
Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29305230/genome-wide-scan-for-seed-composition-provides-insights-into-soybean-quality-improvement-and-the-impacts-of-domestication-and-breeding
#12
Jiaoping Zhang, Xianzhi Wang, Yaming Lu, Siddhi J Bhusal, Qijian Song, Perry B Cregan, Yang Yen, Michael Brown, Guo-Liang Jiang
The complex genetic architecture of quality traits has hindered efforts to modify seed nutrients in soybean (Glycine max). Genome-wide association studies were conducted for the seed composition including protein, oil, fatty acids and amino acids using 313 diverse soybean germplasm accessions genotyped with a high-density SNP array. A total of 87 chromosomal regions were identified to be associated with seed composition, explaining 8-89% of genetic variances. The candidate genes GmSAT1, AK-HSDH, SACPD-C and FAD3A of known function, and putative MtN21 nodulin, FATB and steroid-5-α-reductase involved in N2 fixation, amino acid biosynthesis and fatty acid metabolism were found at the major-effect loci...
January 2, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29303889/factors-influencing-the-diagnostic-accuracy-of-laser-scanning-in-vivo-confocal-microscopy-for-acanthamoeba-keratitis
#13
Ahmad Kheirkhah, Vannarut Satitpitakul, Zeba A Syed, Rodrigo Müller, Sunali Goyal, Elmer Y Tu, Reza Dana
PURPOSE: To determine the factors that influence the sensitivity and specificity of laser-scanning in vivo confocal microscopy (IVCM) for diagnosing Acanthamoeba keratitis (AK). METHODS: This retrospective, controlled study included 28 eyes of 27 patients with AK and 34 eyes of 34 patients with bacterial keratitis (as the control group). All patients had undergone corneal imaging with a laser-scanning IVCM (Heidelberg Retina Tomograph 3 with the Rostock Cornea Module)...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29298778/acanthamoeba-keratitis-in-194-patients-risk-factors-for-bad-outcomes-and-severe-inflammatory-complications
#14
Nicole Carnt, Dana Robaei, Darwin C Minassian, John K G Dart
BACKGROUND/AIMS: To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC). METHODS: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10...
January 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29298652/astragalin-attenuates-uvb-radiation-induced-actinic-keratosis-formation
#15
Jian Zhang, Na Li, Kun Zhang, Ping Pan, Hui Zhang, Ning Li, Qiong Tian, Li Zhang, Wenli Liu, Tianyuan Gao, Xin Mu, Dengchao Feng, Wei Guo, Xiaona Ma
Actinic keratosis (AK), is the most common precancerous skin lesion induced by the excessive ultraviolet B (UVB) and is a significant threat to the public health. UVB exposure causes oxidative DNA damage and is considered to be a significant contributor to AK and subsequent development of skin cancer. Besides, activation of p38 MAPK also plays a significant role in the development of AK. In our clinical findings revealed that p38 MAPK, phospho-MSK1, and γ-H2AX were significantly highly expressed in human AK tissue than the normal healthy skin tissue...
December 29, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29296556/rapid-resolution-of-stromal-keratitis-with-the-assistance-of-oral-voriconazole-in-resistant-acanthamoeba-keratitis
#16
Tzu-Yu Hou, Yun-Chen Chen, Chih-Chien Hsu
Acanthamoeba keratitis (AK) is an unusual infectious disease of the cornea which sometimes leads to blindness. We report the experience of adding oral voriconazole in conjunction with topical antiacanthamoebic drops to treat refractory AK. A 20-year-old girl experienced a deep stromal keratitis with large epithelial defect in the left eye, suspected as AK. The initial best-corrected visual acuity (BCVA) of the eye was counting finger. She received topical chlorhexidine 0.02% and voriconazole 1% during the first 14 days but in vain...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29290186/evaluation-of-nitrate-reductase-assay-for-early-detection-of-multi-and-extensively-drug-resistance-tuberculosis-in-our-setup
#17
Aamer Ikram Ikram, Muhammad Luqman Satti, Farida Khurram Lalani, Gohar Zaman, Adeel Hussain Gardezi, Parvez Ahmed
OBJECTIVE: To evaluate the performance of nitrate reductase assay on smear positive pulmonary specimens for detection of multi and extensively drug resistant tuberculosis simultaneously. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi from June to December 2016. METHODOLOGY: Smear positive pulmonary samples were processed both by nitrate reductase method on Lowenstein Jenson medium and also inoculated on gold standard Bactec MGIT 960 TB system...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29285197/correlation-of-telomere-length-to-malignancy-potential-in-non-melanoma-skin-cancers
#18
Hanae Yamada-Hishida, Yoshimasa Nobeyama, Hidemi Nakagawa
Telomeres are associated with cell fate and aging through their role in the cellular response to stress and growth stimulation resulting from previous cell divisions and DNA damage. Telomere shortening has been observed in most human cancers, and is known to be a feature of malignancy. The aim of this study is to clarify whether telomere length is related to the malignant potential of non-melanoma skin cancers. Telomere length was analyzed using tissue quantitative fluorescence in situ hybridization in 36 non-melanoma skin cancers including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen's disease (BD) and actinic keratosis (AK), and also in 26 samples of normal-appearing epidermal tissue surrounding or located close to each tumor...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29284593/antigen-analysis-of-pre-eclamptic-plasma-antibodies-using-escherichia-coli-proteome-chips
#19
Te-Yao Hsu, Jyun-Mu Lin, Mai-Huong Thi Nguyen, Feng-Hsiang Chung, Ching-Chang Tsai, Hsin-Hsin Cheng, Yun-Ju Lai, Hsuan-Ning Hung, Chien-Sheng Chen
Pre-eclampsia is one of the main causes of perinatal mortality and morbidity. Many biomarkers for diagnosing pre-eclampsia have been found but most have low accuracy. Therefore, a potential marker that can detect pre-eclampsia with high accuracy is required. Infection has been reported as a cause of pre-eclampsia. In recent years, protein microarray chips have been recognized as a strong and robust tool for profiling antibodies for infection diagnoses. The purpose of the present study was to profile antibodies in the human plasma of healthy and pre-eclamptic pregnancies to identify suitable biomarkers...
December 28, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29283376/differential-selective-pressures-experienced-by-the-aurora-kinase-gene-family
#20
Joni M Seeling, Alexis A Farmer, Adam Mansfield, Hyuk Cho, Madhusudan Choudhary
Aurora kinases (AKs) are serine/threonine kinases that are essential for cell division. Humans have three AK genes: AKA, AKB, and AKC. AKA is required for centrosome assembly, centrosome separation, and bipolar spindle assembly, and its mutation leads to abnormal spindle morphology. AKB is required for the spindle checkpoint and proper cytokinesis, and mutations cause chromosome misalignment and cytokinesis failure. AKC is expressed in germ cells, and has a role in meiosis analogous to that of AKB in mitosis...
December 28, 2017: International Journal of Molecular Sciences
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