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https://www.readbyqxmd.com/read/28320407/association-between-sensitivity-of-viral-thymidine-kinase-associated-acyclovir-resistant-herpes-simplex-virus-type-1-and-virulence
#1
Natsumi Omura, Hikaru Fujii, Tomoki Yoshikawa, Souichi Yamada, Shizuko Harada, Takuya Inagaki, Miho Shibamura, Haruko Takeyama, Masayuki Saijo
BACKGROUND: Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) genes. The vTK-associated ACVr HSV-1 shows reduced virulence, but the association between the level of resistance and the virulence of the vTK-associated ACVr HSV-1 is still unclear. METHODS: The virulence in mice of 5 vTK-associated ACVr HSV-1 clones with a variety of ACV sensitivities, when inoculated through intracerebral and corneal routes, was evaluated in comparison with ACV-sensitive (ACVs) parent HSV-1 TAS...
March 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28316142/evolutionary-ecology-of-beta-lactam-gene-clusters-in-animals
#2
Wouter Suring, Karen Meusemann, Alexander Blanke, Janine Mariën, Tim Schol, Valeria Agamennone, Anna Faddeeva-Vakhrusheva, Matty P Berg, Bram Brouwer, Nico M van Straalen, Dick Roelofs
Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida. However, it has remained unclear whether this gene is part of a larger beta-lactam biosynthesis pathway and how widespread the occurrence of penicillin biosynthesis is among animals. Here, we analyzed the distribution of beta-lactam biosynthesis genes throughout the animal kingdom and identified a beta-lactam gene cluster in the genome of F...
March 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28284712/subchronic-toxicity-and-anti-hsv-1-activity-in-experimental-animal-of-dolabelladienetriol-from-the-seaweed-dictyota-pfaffii
#3
Valéria Garrido, Caroline Barros, Vanessa A Melchiades, Rainomar Raimundo Fonseca, Sergio Pinheiro, Patrícia Ocampo, Valéria L Teixeira, Diana N Cavalcanti, Viveca Giongo, Norman A Ratcliffe, Gerlinde Teixeira, Izabel Christina N P Paixão
This study examined in rats the subchronic toxicity and anti- HSV-1activity after oral administration of dolabelladienetriol (D1), a diterpene isolated from the seaweed Dictyota pfaffii. In subchronic toxicity (SCT) tests, female rats received D1 by gavage 15 mg/kg/day (n = 5) for 50 days, and general behavior, death, hematological, biochemical and histological changes in the liver, kidney, stomach, and duodenum were determined. For the anti-HSV-1 activity, female mice were infected and treated orally with a dose of 20 mg/kg (n = 5) twice a day with D1 and any lesions in the skin were then recorded for 18 days...
March 8, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28253893/effect-of-suppressive-acyclovir-administered-to-hsv-2-positive-mothers-from-week-28-to-36%C3%A2-weeks-of-pregnancy-on-adverse-obstetric-outcomes-a-double-blind-randomised-placebo-controlled-trial
#4
Sarah Nakubulwa, Dan K Kaye, Freddie Bwanga, Nazarius Mbona Tumwesigye, Edith Nakku-Joloba, Florence Mirembe
BACKGROUND: Acyclovir (ACV) given to HSV-2 positive women after 36 weeks reduces adverse outcomes but its benefit at lower gestation was undocumented. We determined the effect of oral acyclovir administered from 28 to 36 weeks on premature rupture of membranes (PROM) primarily and preterm delivery risk. METHODS: This was a randomized, double-blind placebo-controlled trial among 200 HSV-2 positive pregnant women at 28 weeks of gestation at Mulago Hospital, Uganda...
March 3, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28245257/cross-linked-%C3%AE-cyclodextrin-and-carboxymethyl-cellulose-hydrogels-for-controlled-drug-delivery-of-acyclovir
#5
Nadia Shamshad Malik, Mahmood Ahmad, Muhammad Usman Minhas
To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N' N'-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network...
2017: PloS One
https://www.readbyqxmd.com/read/28235707/enhancement-of-the-antiviral-activity-against-caprine-herpesvirus-type-1-of-acyclovir-in-association-with-mizoribine
#6
Michele Camero, Domenico Buonavoglia, Maria Stella Lucente, Michele Losurdo, Giuseppe Crescenzo, Paolo Trerotoli, Elisabetta Casalino, Vito Martella, Gabriella Elia, Maria Tempesta
Caprine herpesvirus 1 (CpHV-1) infection in goats is responsible for genital lesions resembling the lesions induced by herpesvirus 2 in humans (HHV-2). The immunosuppressive drug Mizoribine (MIZ) is able to increase the antiviral activity of Acyclovir (ACV) against herpesvirus infections, raising interesting perspectives on new combined therapeutic strategies. In this study the anti-CpHV-1 activity in vitro of ACV alone or in combination with MIZ was evaluated. ACV (100μg/ml) displayed an antiviral effect on CpHV-1 replication...
February 16, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28207520/characterization-of-ocular-biometrics-and-aqueous-humor-dynamics-in-primary-angle-closure-suspects
#7
Li Guo, Yuan Deng, Li Fang, Chaoqi Liu, Tao Guo
Detailed characterizations of ocular biometrics and parameters of aqueous humor dynamics are lacking in primary angle closure suspect (PACS) patients. This study aims to characterize these parameters and compare them with age-matched healthy volunteers.Elderly healthy volunteers (60.6 ± 7.2 years of age, mean ± SD, n = 28) and PACS patients (64.1 ± 11.6 years, n = 30) completed the study. Parameters investigated were axial length (AXL), anterior chamber depth (ACD), anterior chamber volume (ACV), central cornea thickness (CCT), intraocular pressure (IOP), aqueous flow (Fa), outflow facility (C), episcleral venous pressure (EVP), and uveoscleral outflow (Fu)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28180985/crossover-study-of-assist-control-ventilation-and-neurally-adjusted-ventilatory-assist
#8
Sandeep Shetty, Katie Hunt, Janet Peacock, Kamal Ali, Anne Greenough
Some studies of infants with acute respiratory distress have demonstrated that neurally adjusted ventilator assist (NAVA) had better short-term results compared to non-triggered or other triggered models. We determined if very prematurely born infants with evolving or established bronchopulmonary dysplasia (BPD) had a lower oxygenation index (OI) on NAVA compared to assist control ventilation (ACV). Infants were studied for 1 h each on each mode. At the end of each hour, blood gas analysis was performed and the OI calculated...
February 8, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28168046/measurement-of-and-factors-associated-with-the-anterior-chamber-volume-in-healthy-chinese-adults
#9
Yuan Zong, Qian Xu, Chunhui Jiang, Haohao Zhu, Jian Yu, Xinghuai Sun
Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults. Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined. Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159815/validation-of-the-prognostic-utility-of-the-electrocardiogram-for-acute-drug-overdose
#10
Alex F Manini, Ajith P Nair, Rajesh Vedanthan, David Vlahov, Robert S Hoffman
BACKGROUND: While it is certain that some emergency department patients with acute drug overdose suffer adverse cardiovascular events (ACVE), predicting ACVE is difficult. The prognostic utility of the ECG for heterogeneous drug overdose patients remains to be proven. This study was undertaken to validate previously derived features of the initial ECG associated with ACVE in this population. METHODS AND RESULTS: We performed a prospective validation cohort study to evaluate adult emergency department patients with acute drug overdose at 2 urban university hospitals over 5 years in whom an emergency department admission ECG was performed...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28124592/acyclovir-solid-lipid-nanoparticles-for-skin-drug-delivery-fabrication-characterization-and-in-vitro-study
#11
Maria John Newton, Kaur Bhupinder
OBJECTIVE: The fractionated coconut oil based solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated in two batches by using Glyceryl mono stearate (GMS) and Lipoid S75 (Fat free soybean phospholipids with 70% phosphatidylcholine- Lipoid GmbH, Germany). The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. METHODS: The GMS with Fractionated coconut oil and Lipoid S 75 with Fractionated coconut oil were used in various concentrations in formulation design to assess the impact on the fabrication and evaluation of SLNs...
January 17, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28092836/antiviral-drug-acyclovir-exhibits-antitumor-activity-via-targeting-%C3%AE-trcp1-molecular-docking-and-dynamics-simulation-study
#12
Shagufta Shafique, Sajid Rashid
The critical role of βTrCP1 in cancer development makes it a discerning target for the development of small drug like molecules. Currently, no inhibitor exists that is able to target its substrate binding site. Through molecular docking and dynamics simulation assays, we explored the comparative binding pattern of βTrCP1-WD40 domain with ACV and its phospho-derivatives (ACVMP, ACVDP and ACVTP). Consequently, through principal component analysis, βTrCP1-ACVTP was found to be more stable complex by obscuring a reduced conformational space than other systems...
December 31, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28068365/tonographic-effect-of-ocular-response-analyzer-in-comparison-to-goldmann-applanation-tonometry
#13
Martin Zimmermann, Susanne Pitz, Irene Schmidtmann, Norbert Pfeiffer, Joanna Wasielica-Poslednik
AIMS: The tonographic effect is a phenomenon of intraocular pressure (IOP) reduction following repeated tonometry. This study examines whether the tonographic effect occurs following IOP measurement performed with Ocular Response Analyzer (ORA). METHODS: Both eyes of 31 glaucoma patients and 35 healthy controls underwent nine IOP-measurements performed with GAT and ORA. The number of GAT and ORA measurements performed on each eye differed depending on the randomly allocated investigation scheme...
2017: PloS One
https://www.readbyqxmd.com/read/28042660/determination-of-minimum-biofilm-eradication-concentrations-of-orbifloxacin-for-canine-bacterial-uropathogens-over-different-treatment-periods
#14
Takae Shimizu, Kazuki Harada
Biofilm formation can cause refractory urinary tract infections (UTIs) in dogs; however, minimum biofilm eradication concentrations (MBECs) of veterinary drugs against canine uropathogens remain to be investigated. In this study, we determined the MBECs of orbifloxacin (OBFX), trimethoprim-sulfamethoxazole (TMS), and amoxicillin/clavulanate (ACV) over different time periods for treatment of canine uropathogenic Escherichia coli (n = 10). We also determined the MBECs of OBFX for other bacterial uropathogens, including Staphylococcus pseudintermedius (n = 5), Pseudomonas aeruginosa (n = 5), Klebsiella pneumoniae (n=5), and Proteus mirabilis (n=5)...
January 2, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28039754/herpes-zoster-in-autologous-hematopoietic-cell-transplant-recipients-in-the-era-of-acyclovir-or-valacyclovir-prophylaxis-and-novel-treatment-and-maintenance-therapies
#15
Farah Sahoo, Joshua A Hill, Hu Xie, Wendy Leisenring, Jessica Yi, Sonia Goyal, Louise E Kimball, Ingi Lee, Sachiko Seo, Chris Davis, Stephen A Pergam, Mary E Flowers, Kai-Li Liaw, Leona Holmberg, Michael Boeckh
The epidemiology of herpes zoster (HZ) in contemporary autologous hematopoietic cell transplant (HCT) recipients, and the impact of acyclovir (ACV)/valacyclovir (VACV) prophylaxis, is not well described. In this observational study from 2002 to 2010, we retrospectively identified 1000 varicella zoster virus (VZV)-seropositive autologous HCT recipients with up to 5 years of follow-up. The incidence of HZ and use of ACV/VACV prophylaxis were determined through review of medical records and mailed questionnaires...
March 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28027917/profile-of-anti-herpetic-action-of-asp2151-amenamevir-as-a-helicase-primase-inhibitor
#16
Misako Yajima, Hiroshi Yamada, Masaya Takemoto, Tohru Daikoku, Yoshihiro Yoshida, Tan Long, Tomoko Okuda, Kimiyasu Shiraki
The antiherpetic drugs acyclovir (ACV, valaciclovir) and penciclovir (famciclovir) are phosphorylated by viral thymidine kinase and terminate DNA synthesis. ASP2151 (amenamevir) and foscavir (PFA) directly inhibit viral helicase-primase and DNA polymerase, respectively, and inhibit replication of herpes simplex virus (HSV) and varicella-zoster virus. ACV, ASP2151, and PFA all inhibit HSV with a different mechanism of action and as a consequence, the kinetics of viral DNA accumulation and progeny virus production differ...
December 24, 2016: Antiviral Research
https://www.readbyqxmd.com/read/28024582/evaluation-of-poly-lactic-co-glycolic-acid-and-poly-dl-lactide-co-%C3%AE%C2%B5-caprolactone-electrospun-fibers-for-the-treatment-of-hsv-2-infection
#17
Stella E Aniagyei, Lee B Sims, Danial A Malik, Kevin M Tyo, Keegan C Curry, Woihwan Kim, Daniel A Hodge, Jinghua Duan, Jill M Steinbach-Rankins
More diverse multipurpose prevention technologies are urgently needed to provide localized, topical pre-exposure prophylaxis against sexually transmitted infections (STIs). In this work, we established the foundation for a multipurpose platform, in the form of polymeric electrospun fibers (EFs), to physicochemically treat herpes simplex virus 2 (HSV-2) infection. To initiate this study, we fabricated different formulations of poly(lactic-co-glycolic acid) (PLGA) and poly(dl-lactide-co-ε-caprolactone) (PLCL) EFs that encapsulate Acyclovir (ACV), to treat HSV-2 infection in vitro...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27938955/limbus-insertion-distance-of-superior-rectus-in-primary-angle-closure-glaucoma-an-anterior-segment-oct-study
#18
Wenbin Huang, Xinbo Gao, Xinyu Zhang, Xiulan Zhang
OBJECTIVE: To compare the distance from the corneoscleral limbus to the insertion site of the superior rectus of primary angle-closure glaucoma (PACG) patients with normal controls and to identify potential characteristics associated with limbus-insertion distance. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 92 subjects (eyes) were enrolled in the study: 35 were nonglaucoma controls and 57 were PACG patients. METHODS: The limbus-insertion distance of the superior rectus was measured by anterior segment optical coherence tomography (AS-OCT) and intraoperative surgical caliper...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27896415/predicting-risk-factors-for-varicella-zoster-virus-infection-and-postherpetic-neuralgia-after-hematopoietic-cell-transplantation-using-ordered-logistic-regression-analysis
#19
Yuko Kanbayashi, Yosuke Matsumoto, Junya Kuroda, Tsutomu Kobayashi, Shigeo Horiike, Toyoshi Hosokawa, Masafumi Taniwaki
To identify risk factors for varicella zoster virus (VZV) infection and postherpetic neuralgia (PHN) after hematopoietic cell transplantation (HCT), we conducted a retrospective chart review of 163 consecutive patients who underwent HCT between November 2004 and July 2014. Overall, the male/female (M/F) ratio was 80/83, median age at HCT was 54 (range 15-69) years, and autologous/allogeneic HCT (auto/allo-HCT) ratio was 71/92. Forty-four patients [M/F, 25/19; median age, 57 (range: 16-68) years; auto/allo-HCT, 26/18] developed VZV infection after HCT...
February 2017: Annals of Hematology
https://www.readbyqxmd.com/read/27872755/changes-in-anterior-segment-morphology-of-iris-bombe-before-and-after-laser-peripheral-iridotomy-in-patients-with-uveitic-secondary-glaucoma
#20
Wakako Ikegawa, Takashi Suzuki, Koji Namiguchi, Shiro Mizoue, Atsushi Shiraishi, Yuichi Ohashi
Purpose. To quantify changes in anterior segment (AS) parameters after laser peripheral iridotomy (LPI) using AS-optical coherence tomography (OCT) of iris bombe. Method. AS images of eight eyes were captured before and after iris bombe and more than 2 weeks after LPI (post-LPI) using AS-OCT. We compared the following AS parameters: anterior chamber depth (ACD), anterior chamber volume (ACV), iris curvature (IC), iris thickness at 500 μm from the scleral spur (IT-1) in the middle between the iris root and pupillary margin (IT-2) and 500 μm from the pupillary margin (IT-3) to the anterior chamber angle (ACA) (angle opening distance [AOD750]), and trabecular iris space area...
2016: Journal of Ophthalmology
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