Sebastian T Lugg, Kerrie A Alridge, Phillip A Howells, Dhruv Parekh, Aaron Scott, Rahul Y Mahida, Daniel Park, Olga Tucker, Fang Gao, Gavin D Perkins, David R Thickett, Rachel C A Dancer
Acute respiratory distress syndrome (ARDS) has a significant impact on post-operative morbidity and mortality following oesophagectomy. Smoking is a risk factor for the development of ARDS, although the mechanism is unclear. We examined the effect of smoking on alveolar and systemic inflammation, in addition to alveolar-capillary permeability, leading to ARDS in patients undergoing oesophagectomy. We compared clinical, biomarker and PiCCO system data between current smokers (n=14) and ex-smokers (n=36) enrolled into a translational substudy of the BALTI-P (Beta Agonist Lung Injury Trial Prevention) trial...
February 2019: ERJ Open Research