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Extravascular long water

Yi Li, Wanhong Yin, Yao Qin, Xueying Zeng, Tongjuan Zou, Xiaoting Wang, Yangong Chao, Lina Zhang, Yan Kang, Chinese Critical Ultrasound Study Group Ccusg
Objective: To preliminarily describe the epidemiologic and hemodynamic characteristics of critically ill patients with restrictive filling diastolic dysfunction based on echocardiography. Setting: A retrospective study. Methods: Epidemiologic characteristics of patients with restrictive filling diastolic dysfunction in ICU were described; clinical and hemodynamic data were preliminarily summarized and compared between patients with and without restrictive filling diastolic dysfunction; most of the data were based on echocardiography...
2018: BioMed Research International
Hatef Mehrabian, Kimberly L Desmond, Sofia Chavez, Colleen Bailey, Radoslaw Rola, Arjun Sahgal, Gregory J Czarnota, Hany Soliman, Anne L Martel, Greg J Stanisz
PURPOSE: This study was designed to evaluate whether changes in metastatic brain tumors after stereotactic radiosurgery (SRS) can be seen with quantitative MRI early after treatment. METHODS AND MATERIALS: Using contrast-enhanced MRI, a 3-water-compartment tissue model consisting of intracellular (I), extracellular-extravascular (E), and vascular (V) compartments was used to assess the intra-extracellular water exchange rate constant (kIE ), efflux rate constant (kep ), and water compartment volume fractions (M0,I , M0,E , M0,V )...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
J Ambrozic, K Prokselj, M Lucovnik
INTRODUCTION: The ability to judge intravascular volume is fundamental in the management of patients with severe preeclampsia. Insufficient intravascular volume can result in decreased oxygen delivery to tissues and exacerbates organ dysfunction. On the other hand, fluid excesses can lead to fluid extravasation and pulmonary edema. Outside of pregnancy, transthoracic echocardiography and lung ultrasonography have become important diagnostic and monitoring tools in critically ill patients...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Michael Fritzenwanger, Bjoern Kabisch, Hans-Reiner Figulla, Christian Jung
BACKGROUND: Heart failure is known to be a major public health problem. Fluid redistribution contributes to acute heart failure; therefore, knowledge of hemodynamic parameters could be important for optimizing outcomes. The pulse contour cardiac output monitor PiCCO uses the single thermal indicator technique and pulse contour analysis to calculate hemodynamic parameters of preload, afterload, cardiac output, systemic vascular resistance and extravascular lung water. OBJECTIVES: We primarily aimed to describe values and parameters seen in acute heart failure patients admitted to the intensive care unit (ICU) and secondly to investigate associations between hemodynamic measurements and survival data...
December 2016: Wiener Klinische Wochenschrift
Wei Zhang, Hui Juan Chen, Zhen J Wang, Wei Huang, Long Jiang Zhang
PURPOSE: To investigate whether dynamic contrast -enhanced MRI (DCE-MRI) can distinguish the type of liver nodules in a rat model with N-nitrosodiethylamine- induced cirrhosis. METHODS: Liver nodules in cirrhosis were induced in 60 male Wistar rats via 0.01 % N-nitrosodiethylamine in the drinking water for 35-100 days. The nodules were divided into three groups: regenerative nodule (RN), dysplastic nodule (DN), and hepatocellular carcinoma (HCC). DCE-MRI was performed, and parameters including transfer constant (K(trans)), rate constant (Kep), extravascular extracellular space volume fraction (Ve), and initial area under the contrast concentration versus time curve (iAUC) were measured and compared...
May 2017: European Radiology
Hao Wang, Na Cui, Longxiang Su, Yun Long, Xiaoting Wang, Xiang Zhou, Wenzhao Chai, Dawei Liu
PURPOSES: To explore whether extravascular lung water (EVLW) provides a valuable prognostic tool guiding fluid therapy in septic shock patients after initial resuscitation. MATERIALS AND METHODS: We performed a retrospective study of septic shock patients who achieved adequate initial fluid resuscitation with extended hemodynamic monitoring, analyzing the prognostic value of EVLW and whether fluid therapy for 24 (T24) or 24-48 hours (T24-48) after initial resuscitation with a recommended value of EVLW yielded a 28-day mortality advantage...
June 2016: Journal of Critical Care
B Aydin, M Ozban, M Serinken, B Kaptanoglu, N C Demirkan, C Aydin
INTRODUCTION: Acute mesenteric ischemia (AMI) is an abdominal-vascular emergency which is rare and has high mortality rates (60-80 %) due to late diagnosis (1-3). Although it is known that extravascular reasons like intestinal intussusception, volvulus, strangulated hernias and obstructions can cause intestinal gangrene, these are rarely the cause of AMI (1). MATERIALS AND METHODS: In this study, we used male Wistar-Albino rats weighing 250-300 grams obtained from Pamukkale University Experimental Research Laboratory...
2015: Bratislavské Lekárske Listy
Stephen F Rodrigues, D Neil Granger
The barrier properties of endothelial cells are critical for the maintenance of water and protein balance between the intravascular and extravascular compartments. An impairment of endothelial barrier function has been implicated in the genesis and/or progression of a variety of pathological conditions, including pulmonary edema, ischemic stroke, neurodegenerative disorders, angioedema, sepsis and cancer. The altered barrier function in these conditions is often linked to the release of soluble mediators from resident cells (e...
2015: Tissue Barriers
Quan Hu, Ming-Hua Du, Sen Hu, Jia-ke Chai, Hong-Min Luo, Xiao-Han Hu, Lin Zhang, Zhi-Long Lin, Li Ma, Huan Wang, Zhi-Yong Sheng
Excessive inflammation and high vasopermeability can lead to blood volume loss and tissue edema, which can affect the resuscitation and prognosis for serious burn patients. In this experiment, we investigated the effect of PNU-282987, an α7 nicotine cholinergic receptor agonist on the hemodynamic parameters and survival rate by inhibiting vasopermeability and tissue edema during the fluid resuscitation for lethal burn shock. Forty Beagle dogs with intubation of the carotid artery and jugular vein 24 hours before the injury were subjected to 50% TBSA full-thickness burns, and were randomly divided into following four groups: no resuscitation group (group NR), venous fluid resuscitation group (group R), PNU-282987 treatment group (group P), and fluid resuscitation group plus PNU-282987 group (group RP), with 10 dogs in each group...
July 2014: Journal of Burn Care & Research: Official Publication of the American Burn Association
Karine Prado, Christophe Maurel
The water status of plant leaves is dependent on both stomatal regulation and water supply from the vasculature to inner tissues. The present review addresses the multiple physiological and mechanistic facets of the latter process. Inner leaf tissues contribute to at least a third of the whole resistance to water flow within the plant. Physiological studies indicated that leaf hydraulic conductance (K leaf) is highly dependent on the anatomy, development and age of the leaf and can vary rapidly in response to physiological or environmental factors such as leaf hydration, light, temperature, or nutrient supply...
2013: Frontiers in Plant Science
Hong-Min Luo, Ming-Hua Du, Zhi-Long Lin, Quan Hu, Lin Zhang, Li Ma, Huan Wang, Yu Wen, Yi Lv, Hong-Yuan Lin, Yu-Li Pi, Sen Hu, Zhi-Yong Sheng
Objective. Lipid peroxidation plays a critical role in burn-induced plasma leakage, and ulinastatin has been reported to reduce lipid peroxidation in various models. This study aims to examine whether ulinastatin reduces fluid requirements through inhibition of lipid peroxidation in a swine burn model. Methods. Forty miniature swine were subjected to 40% TBSA burns and were randomly allocated to the following four groups: immediate lactated Ringer's resuscitation (ILR), immediate LR containing ulinastatin (ILR/ULI), delayed LR resuscitation (DLR), and delayed LR containing ulinastatin (DLR/ULI)...
2013: Oxidative Medicine and Cellular Longevity
Ming Fang, Miao Chen, Chong-wei Zheng, Yi-Yu Deng, Bei Hu, Xue Liu, Wei-ping Huang, Yi Long, Wen-xin Jiang, Hong-ke Zeng
OBJECTIVE: To investigate the values of extravascular lung water and preload parameters of weaning from mechanical ventilation on patients with septic shock. METHODS: A prospective study was conducted. A total of 52 septic shock patients with mechanical ventilation were enrolled from January 2010 to July 2012. All patients were treated and monitored by pulse induced continuous cardiac output (PiCCO) till they reached weaning criteria, and then spontaneous breathing trial (SBT), weaning, and extubation were performed in turn...
January 2013: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Nicolas Adrien Pannetier, Clément Stéphan Debacker, Franck Mauconduit, Thomas Christen, Emmanuel Luc Barbier
The quantification of bolus-tracking MRI techniques remains challenging. The acquisition usually relies on one contrast and the analysis on a simplified model of the various phenomena that arise within a voxel, leading to inaccurate perfusion estimates. To evaluate how simplifications in the interstitial model impact perfusion estimates, we propose a numerical tool to simulate the MR signal provided by a dynamic contrast enhanced (DCE) MRI experiment. Our model encompasses the intrinsic R1 and R2 relaxations, the magnetic field perturbations induced by susceptibility interfaces (vessels and cells), the diffusion of the water protons, the blood flow, the permeability of the vessel wall to the the contrast agent (CA) and the constrained diffusion of the CA within the voxel...
2013: PloS One
People visiting or living in tropical or subtropical regions are exposed to various factors, which can lead to edema. Tourists staying for only a short time in the tropics are exposed to different risks, with other disease patterns, than people living in the tropics or immigrants from tropical regions. The differential diagnosis of edema and swelling is extensive and it can sometimes be difficult to distinguish classical edema with fluid retention in the extravascular interstitial space, from lymphedema or swelling due to other aetiologies...
November 1, 2004: Therapeutische Umschau. Revue Thérapeutique
Hanzhang Lu, Peter C M van Zijl
Vascular-Space-Occupancy (VASO) fMRI is a non-invasive technique to detect brain activation based on changes in Cerebral Blood Volume (CBV), as opposed to conventional BOLD fMRI, which is based on changes in blood oxygenation. This technique takes advantage of the T1 difference between blood and surrounding tissue, and uses an inversion recovery pulse sequence to null blood signal while maintaining part of the tissue signal. The VASO signal intensity can thus be considered proportional to 1-CBV. When neural activation causes CBV to increase, the VASO signal will show a decrease, allowing the detection of activated regions in the brain...
August 15, 2012: NeuroImage
Boon K Tan, David Smith, Patrik Spanel, Simon J Davies
Pulmonary oedema is a medical condition characterized by abnormal accumulation of fluid in the extravascular space in the alveoli. Effective oxygenation is impaired and this leads to significant short- and long-term morbidity and mortality. The detection and monitoring of pulmonary oedema by measuring lung water volume is therefore crucial in the initiation and guidance of therapeutic intervention. The current gold standard bedside measurement of extravascular lung water volume (EVLW) is the dilution method using various indicators, but despite the good correlation of the results with those obtained using the post-mortem gravimetric method, the invasiveness of the dilution technique limits its general application in the wider clinical setting...
March 2010: Journal of Breath Research
Fitz-Roy E Curry, Roger H Adamson
Multiple processes modulate net blood-to-tissue exchange in a microvascular unit in normal and pathophysiological conditions. These include mechanisms that control the number and type of microvessels perfused, the balance of adhesion and contractile forces that determine the conductance of the spaces between endothelial cells to water and solutes, the pressure and chemical potential gradients determining the driving forces through these conductive pathways, and the organization of barriers to macromolecules in the endothelial glycocalyx...
July 15, 2010: Cardiovascular Research
Mahmoud M Othman, Ahmed Z Ismael, Golinar E Hammouda
BACKGROUND: Early graft function is crucial for successful kidney transplantation. Maintaining adequate hydration is complicated by rapid movement of water to the extravascular space. We designed this study to test the effect of maximal hydration during graft ischemia time on early renal function. METHODS: Forty adult patients with chronic renal failure underwent renal transplantation from related living donors. Study subjects were randomly assigned 1 of 2 regimens for intraoperative hydration...
May 1, 2010: Anesthesia and Analgesia
Y R Kim, E Tejima, S Huang, D N Atochin, G Dai, E H Lo, P L Huang, A Bogdanov, B R Rosen
Mechanisms that underlie early ischemic damages to the blood-brain-barrier (BBB) are not well understood. This study presents a novel magnetic resonance imaging (MRI) technique using a widely available pulse sequence and a long-circulating intravascular contrast agent to quantify water movements across the BBB at early stages of stroke progression. We characterized the integrity of the BBB by measuring the flip angle dependence of the water exchange-affected MRI signal intensity, to generate an efficient quantitative index of vascular permeability (WEI, or water exchange index)...
October 2008: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Lisa Beckmann, Dirk van Riesen, Steffen Leonhardt
Bioimpedance Spectroscopy (BIS) is a non-invasive technique for the determination of human body composition such as water or fat content. Next to absolute body water determination, it enables also the detection of body water shifts. Therefore, it seems to be a good candidate to detect cardiac lung edema at an early stage and to monitor its medical treatment. However, stable long term BIS measurements are very difficult to make. The measurement conditions and hardware specifications of BIS devices must be well chosen in order to get correct and reproducible results...
2007: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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