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https://www.readbyqxmd.com/read/28333878/one-year-results-of-half-versus-standard-dose-photodynamic-therapy-combined-with-ranibizumab-for-polypoidal-choroidal-vasculopathy
#1
Ian Y Wong, Xuan Shi, Rita Gangwani, Lawrence P Iu, Nicholas Fung, Qing Li, Alex L K Ng, Xiaoxin Li
PURPOSE: To explore the efficacy of half-dose verteporfin photodynamic therapy (hd-PDT) and standard-dose photodynamic therapy (sd-PDT), when combined with ranibizumab in the treatment of polypoidal choroidal vasculopathy. METHODS: Subjects were allocated to either the hd-PDT arm or the sd-PDT arm. All subjects received an injection of ranibizumab and PDT treatment (dosage according to allocation) at baseline. Subjects were followed up monthly for 12 months, and re-treatment were given at each visit if criteria were met...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28333854/presumed-retinal-pigment-epithelium-tumor-originating-from-unilateral-retinal-pigment-epithelium-dysgenesis
#2
Orly Gal-Or, Paul T Finger, Yale L Fisher, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe a patient with a presumed retinal pigment epithelium (RPE) tumor originating from unilateral RPE dysgenesis. METHODS: Case report. RESULTS: A 30-year-old woman with an unremarkable medical and ocular history was referred for an evaluation of progressive central metamorphopsia in her left eye. Visual acuity was 20/20 in her right eye and 20/25 in her left eye. Funduscopic examination of the left eye revealed an elevated mass within an area of unilateral RPE dysgenesis showing hyperpigmentation and hypopigmentation with scalloped margins...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333853/multimodal-imaging-in-vortex-vein-varices
#3
Chiara Veronese, Giovanni Staurenghi, Marco Pellegrini, Chiara Maiolo, Laura Primavera, Mariachiara Morara, Grayson W Armstrong, Antonio P Ciardella
PURPOSE: The aim of this study is to describe the clinical presentation of vortex vein varices with multimodal imaging. METHODS: The authors carried out a retrospective case series of eight patients (7 female, 1 male) with an average age of 60.2 years (min 8, max 84, median 68.5) presenting with vortex vein varices. All patients were evaluated at the Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy and at Luigi Sacco Hospital, University of Milan, Milan, Italy...
March 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28333783/dome-shaped-macula-in-myopic-eyes-twelve-month-follow-up
#4
Daniel Lorenzo, Luis Arias, Netan Choudhry, Eduard Millan, Ignacio Flores, Marcos J Rubio, Estefanía Cobos, Pere García-Bru, Alejandro Filloy, Josep M Caminal
PURPOSE: To study the long-term clinical course of dome-shaped macula in myopic eyes and to evaluate treatment efficacy for subretinal fluid (SRF) as a related complication. METHODS: A retrospective, single-center consecutive case series study was conducted. The authors analyzed myopic eyes with dome-shaped macula in patients who presented for evaluation of decreased vision. Dome-shaped macula was defined as a convexity of the retina-choroidal macular complex seen on spectral domain optical coherence tomography images...
April 2017: Retina
https://www.readbyqxmd.com/read/28328661/microangiography-to-monitor-treatment-outcomes-following-severe-frostbite-injury-to-the-hands
#5
Thomas Masters, Steven Omodt, Jon Gayken, Christopher Logue, Bjorn Westgard, Stephen Hendriksen, Joseph Walter, Rachel Nygaard
Frostbite injury causes direct damage to tissues following exposure to temperatures below their freezing point causing tissue death potentially leading to serious amputations. After rewarming, a variety of treatment options have been employed to avoid amputation. This case report details the use of indocyanine green fluorescence microangiography to monitor the clinical progression of perfusion following hyperbaric oxygen therapy (HBOT) for severe frostbite injury. We present a case report of a man with deep frostbite of the bilateral hands treated with thrombolytics and HBOT...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28328630/fluorescein-isothiocyanate-a-novel-application-for-lymphatic-surgery
#6
Lisa Spiguel, Christiana Shaw, Adam Katz, Lifei Guo, Hung-Chi Chen, Bernard T Lee, Dhruv Singhal
The Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) procedure entails performing a lymphovenous bypass (LVB) at the time of axillary lymph node dissection to reduce lymphedema risk. The two most common fluorophores utilized in LVB are blue dye and indocyanine green. We developed a novel application of fluorescein isothiocyanate for intraoperative lymphatic mapping. Our goal is to demonstrate the safety and efficacy of fluorescein isothiocyanate for this application. We reviewed a prospectively collected database on breast cancer patients who underwent LYMPHA from March to September 2015...
March 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28326662/prediction-of-recurrence-following-hepatectomy-in-patients-with-hepatitis-c-virus-infection-related-hepatocellular-carcinoma-who-achieved-a-sustained-virological-response
#7
Sho Okimoto, Tsuyoshi Kobayashi, Shintaro Kuroda, Kohei Ishiyama, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Seiichi Shimizu, Hiroshi Iwako, Michinori Hamaoka, Naruhiko Honmyo, Megumi Yamaguchi, Hideki Ohdan
AIM: The risk of hepatitis C virus infection-related hepatocellular carcinoma (HCC) is lower, with a better prognosis, in patients who achieve a sustained virological response (SVR) than in those who do not. We aimed to identify risk factors of post-hepatectomy HCC recurrence in patients who achieved a SVR. METHODS: This retrospective study included 349 HCC patients who underwent an initial radical hepatectomy at our institution between January 2005 and December 2014...
March 21, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28323573/real-time-direct-evidence-of-the-superficial-lymphatic-drainage-effect-of-intermittent-pneumatic-compression-treatment-for-lower-limb-lymphedema
#8
Shinya Kitayama, Jiro Maegawa, Shinobu Matsubara, Shinji Kobayashi, Taro Mikami, Koichi Hirotomi, Shintaro Kagimoto
BACKGROUND: Intermittent pneumatic compression (IPC) is a widely used lymph drainage therapy that can be performed at home. However, the effectiveness of IPC for lymph drainage remains unclear. The aim of this study is to investigate the real-time change in the lymph flow velocity during IPC and consider which mode and pressure are best for treating lower limb lymphedema. METHODS AND RESULTS: Eight lower left limbs of 8 healthy volunteers and 17 lower limbs of 15 secondary lymphedema patients were investigated...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28321351/bilateral-birdshot-retinochoroiditis-and-retinal-astrocytoma
#9
Sunil Mamtora, Yun Wong, Dugald Bell, Teresa Sandinha
Background. This case highlights the importance of recognising multiple pathologies within the eye which may not necessarily be linked. Both birdshot retinochoroiditis and astrocytoma are rare conditions. The case underlines the need for early identification and treatment of birdshot retinochoroiditis with steroids and disease modifying drugs. Astrocytoma in the absence of tuberous sclerosis is also uncommon. Case Presentation. A 36-year-old male presented with 3-month history of bilateral progressive flashing lights and floaters...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28316935/anaphylactic-shock-after-intravenous-administration-of-indocyanine-green-during-robotic-partial-nephrectomy
#10
William Chu, Avinash Chennamsetty, Robert Toroussian, Clayton Lau
Indocyanine Green (ICG) is frequently used during urologic robotic procedures and is generally considered to be safe. However, there are reported cases of severe complications from ICG when used for non-urologic purposes. We present the first case to our knowledge of anaphylactic shock in response to intravenous ICG during a robotic partial nephrectomy.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28315801/use-of-indocyanine-green-fluorescence-endoscopy-to-treat-concurrent-perimedullary-and-dural-arteriovenous-fistulas-in-the-cervical-spine
#11
Akira Ito, Toshiki Endo, Tomoo Inoue, Hidenori Endo, Kenichi Sato, Teiji Tominaga
BACKGROUND: Intraoperative microscopic fluorescence angiography using indocyanine green (ICG) provides visual information on real-time blood flow. However, this method cannot be applied for lesions that are not visible under microscopic imaging because excitation light does not reach the targeted vascular structures. Endoscope-integrated ICG video-angiography has recently been advocated to compensate for this limitation. This is the first reported case of a spinal arteriovenous malformation in which endoscope-integrated ICG video-angiography was successfully used...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28314832/features-of-the-choriocapillaris-in-myopic-maculopathy-identified-by-optical-coherence-tomography-angiography
#12
Kaori Sayanagi, Yasushi Ikuno, Sato Uematsu, Kohji Nishida
AIM: To describe the choriocapillaris features imaged by optical coherence tomography angiography (OCTA) in eyes with myopic maculopathy. METHODS: In this retrospective, non-invasive, observational case series, 26 eyes with myopic maculopathy and 12 age-matched healthy eyes underwent fluorescein angiography, indocyanine green angiography (ICGA) (highly myopic eyes only), OCT and OCTA, and the choriocapillaris features seen on OCTA and ICGA were compared. RESULTS: In all five (19%) eyes with patchy atrophy of the 26 highly myopic eyes, OCTA showed complete loss of the choriocapillaris and large choroidal vessels in the atrophic area...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314525/intraoperative-electromagnetic-navigational-bronchoscopic-localization-of-small-deep-or-subsolid-pulmonary-nodules
#13
Abbas Abbas, Sagar Kadakia, Vishnu Ambur, Kimberly Muro, Larry Kaiser
BACKGROUND: Localizing small or deep pulmonary nodules or subsolid ground-glass opacities often is difficult during video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS). This can result in larger resections or conversion to thoracotomy. The goal of this study is to evaluate the role of electromagnetic navigational bronchoscopic localization (ENBL) as a safe and accurate intraoperative method to localize small, deep, or subsolid nodules. METHODS: This is a single-institution, single-surgeon retrospective study of all patients (51) who underwent combined ENBL and resection of 54 nodules between May 2013 and August 2015...
February 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#14
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28299496/contribution-of-dual-fluorescein-and-indocyanine-green-angiography-to-the-appraisal-of-posterior-involvement-in-birdshot-retinochoroiditis-and-vogt-koyanagi-harada-disease
#15
Ozlem Balci, Bruno Jeannin, Carl P Herbort
PURPOSE: To assess the levels of retinal and choroidal involvement in initial-onset birdshot retinochoroiditis (BRC) and Vogt-Koyanagi-Harada (VKH) disease, two stromal choroiditis entities. METHODS: This retrospective study included patients diagnosed with BRC and VKH, seen during initial-onset disease at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiographic signs were quantified, using an established dual fluorescein angiography (FA) and indocyanine green angiography (ICGA) scoring system for uveitis, and the FA/ICGA score ratios were compared between diseases...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28299004/contribution-of-dual-fluorescein-and-indocyanine-green-angiography-to-the-appraisal-of-presumed-tuberculous-chorioretinitis-in-a-non-endemic-area
#16
Raphael Massy, Carl P Herbort
PURPOSE: To assess the respective involvement of retina versus choroid in presumed ocular tuberculosis (POT) in a non-endemic area using dual fluorescein (FA) and indocyanine green angiography (ICGA). METHODS: We retrospectively analyzed cases diagnosed with POT at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiography signs were quantified using an established dual FA and ICGA scoring system for uveitis. RESULTS: Out of 1739 uveitis patients visited from 1995 to 2014, 53 (3%) were diagnosed with POT; of whom 28 patients (54 eyes) had sufficient data available to be included in this study...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28292878/pneumonia-treatment-by-photodynamic-therapy-with-extracorporeal-illumination-an-experimental-model
#17
Mariana C Geralde, Ilaiáli S Leite, Natalia M Inada, Ana Carolina G Salina, Alexandra I Medeiros, Wolfgang M Kuebler, Cristina Kurachi, Vanderlei S Bagnato
Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is emerging as a promising approach, as effects are based on oxidative stress, preventing microorganism resistance. In two previous studies, the in vitro inactivation of Streptococcus pneumoniae using indocyanine green (ICG) and infrared light source was a success killing 5 log10 colony-forming units (CFU/mL) with only 10 μmol/L ICG. In this work, a proof-of-principle protocol was designed to treat lung infections by PDT using extracorporeal illumination with a 780 nm laser device and also ICG as photosensitizer...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28292569/indocyanine-green-applications-in-plastic-surgery-a-review-of-the-literature
#18
Pierre Burnier, Jérémy Niddam, Romain Bosc, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Use of indocyanine green (ICG) near-infrared fluorescence as a dye to assess tissue vascularization is now well standardized. The aim of this literature review was to review and resume the most recent recommendations for ICG use in its plastic surgery applications. METHODS: A systematic literature review was performed using Medline, EMBASE, and PubMed databases to obtain the latest recommendations for ICG in plastic surgery. Inclusion criteria were all articles written in English language that evaluated pre-, intra-, or postoperative ICG applications in surgical procedures usually performed by plastic surgeons...
February 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28290667/injectable-polypeptide-thermogel-as-a-tissue-engineering-system-for-hepatogenic-differentiation-of-tonsil-derived-mesenchymal-stem-cells
#19
Ja Hye Hong, Hyun Jung Lee, Byeongmoon Jeong
A poly(ethylene glycol)-b-poly(l-alanine) (PEG-l-PA) hydrogel incorporating tonsil-derived mesenchymal stem cells (TMSCs), tauroursodeoxycholic acid (TUDCA), hepatocyte growth factor (HGF), and fibroblast growth factor 4 (FGF4) was prepared through thermal gelation of an aqueous polymer solution for an injectable tissue engineering application. The thermal gelation accompanied conformational changes of both PA and PEG blocks. The gel modulus at 37 °C was controlled to be 1000 Pa by using a 14.0 wt % aqueous polymer solution...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28288589/choroidal-infarction-in-a-glaucoma-patient-with-flammer-syndrome-a-case-report-with-a-long-term-follow-up
#20
Barbara Terelak-Borys, Iwona Grabska-Liberek, Anita Piekarniak-Wozniak, Katarzyna Konieczka
BACKGROUND: We present a long term follow-up of a young female patient with choroidal infarction, primary open angle glaucoma and Flammer syndrome. The patient had no classical risk factors for vascular occlusions, except for the presence of Flammer syndrome. The essential feature of this syndrome is primary vascular dysregulation, sometimes including vasospasm. The vessels of affected people respond more intensely to a number of stimuli, such as coldness or emotional stress. Any organ can be involved, including parts of the eye...
March 14, 2017: BMC Ophthalmology
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