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https://www.readbyqxmd.com/read/28433837/internal-maxillary-bypass-for-complex-pediatric-aneurysms
#1
Long Wang, Shuaibin Lu, Hai Qian, Xiang'en Shi
BACKGROUND: Complex pediatric aneurysms (PAs) are an unusual clinicopathologic entity, and data remain limited regarding the use of a bypass procedure to treat this formidable disorder. METHODS: Internal maxillary artery (IMA) to middle cerebral artery (MCA) bypass with radial artery graft (RAG) was utilized to isolate PAs. Bypass patency and aneurysm stability were evaluated using intraoperative Doppler ultrasound, indocyanine green videoangiography and postoperative angiography...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28433445/parapapillary-choroidal-microvasculature-dropout-in-glaucoma-a-comparison-between-optical-coherence-tomography-angiography-and-indocyanine-green-angiography
#2
Eun Ji Lee, Kyoung Min Lee, Seung Hyen Lee, Tae-Woo Kim
PURPOSE: To investigate whether the parapapillary choroidal microvasculature dropout (MvD) determined by optical coherence tomography angiography (OCTA) in glaucomatous eyes indicates a true perfusion defect and whether the MvD accurately represents the area of nonperfusion. DESIGN: Observational case series. PARTICIPANTS: Thirty primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by OCTA and 13 POAG patients without this dropout...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28429764/fabrication-characterization-and-biological-evaluation-of-anti-her2-indocyanine-green-doxorubicin-encapsulated-peg-b-plga-copolymeric-nanoparticles-for-targeted-photochemotherapy-of-breast-cancer-cells
#3
Yu-Hsiang Lee, Da-Sheng Chang
In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. The HIDPPNPs were fabricated using a solvent evaporation technique followed by carbodiimide-mediated antibody conjugation on the nanoparticle surface...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428893/characteristics-and-racial-variations-of-polypoidal-choroidal-vasculopathy-in-tertiary-centers-in-the-united-states-and-united-kingdom
#4
Tarek Alasil, Nelida Munoz, Pearse A Keane, Adnan Tufail, Patrick A Coady, Eduardo Novais, Talisa E de Carlo, Caroline R Baumal, Nadia K Waheed, Jay S Duker, Ron A Adelman
PURPOSE: To evaluate the characteristics and racial variations amongst patients with polypoidal choroidal vasculopathy (PCV) in the United States and the United Kingdom. METHODS: Fundus photos and indocyanine green angiography images were evaluated in a multicenter retrospective study to establish the diagnosis of PCV. Visual acuity (VA) was recorded in ETDRS letter count. RESULTS: Eighty eyes of 71 PCV patients (average age of 69.4 ± 10...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28427063/optical-coherence-tomography-angiography-in-diabetic-maculopathy
#5
Gabriel Coscas, Marco Lupidi, Florence Coscas
Fluorescein angiography (FA) and indocyanine green angiography have provided information about the normal retinal and choroidal anatomy, nearly comparable to histological findings. These tests have been fundamental in the evaluation of all retinal and choroidal vascular diseases and have allowed clinicians to define and diagnose several pathological conditions. FA became the "gold standard" in retinal imaging due to the capacity to visualize the retinal capillary bed and its changes, both in the macular area and in the periphery...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28420899/three-dimensional-imaging-of-lymphatic-system-in-lymphedema-legs-using-interstitial-computed-tomography-lymphography
#6
Kiyoshi Yamada, Akira Shinaoka, Yoshihiro Kimata
As a new trial, we used interstitial computed tomography-lymphography (CT-LG) in 10 patients with lower extremity lymphedema (n=20 limbs) at stage 0, 1, 2, or 3 under the International Society of Lymphology (ISL) classification. In all cases, CT-LG, lymphoscintigraphy, and indocyanine green fluorescence-lymphography (ICG-LG) were performed. In the examination of the ascending level of depicted lymphatic vessels, we measured the diameters of lymphatic vessels detected with CT-LG and conducted an image analysis of dermal backflow of lymph (DB)...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28417618/indocyanine-green-videoangiography-application-in-distal-m4-middle-cerebral-artery-aneurysm-surgery
#7
Oriela Rustemi, Renato Scienza, Alessandro Della Puppa
No abstract text is available yet for this article.
June 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28417617/indocyanine-green-videoangiography-the-thin-border-between-a-useful-tool-and-an-illusion-of-safety
#8
Giacomo Pavesi, Andrea Prontera, Alberto Feletti
No abstract text is available yet for this article.
June 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28416757/theranostic-imaging-of-liver-cancer-using-targeted-optical-mri-dual-modal-probes
#9
Qingshan Chen, Wenting Shang, Chaoting Zeng, Kun Wang, Xiaoyuan Liang, Chongwei Chi, Xiao Liang, Jian Yang, Chihua Fang, Jie Tian
The accurate preoperative detection and intraoperative navigation afforded by imaging techniques have had significant impact on the success of liver cancer surgeries. However, it is difficult to achieve satisfactory performance in both diagnosis and surgical treatment processes using any single modality imaging method. Here, we report the synthesis and characteristics of a novel dual-modality magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) probe and verify its feasibility in nude mouse models with liver cancer...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415938/indocyanine-green-detects-sentinel-lymph-nodes-in-early-breast-cancer
#10
Jun Liu, Linping Huang, Ning Wang, Ping Chen
Objective To explore the clinical value of indocyanine green (ICG) for the fluorescence-guided detection of sentinel lymph nodes (SLNs) during sentinel lymph node biopsy (SLNB) in patients with early breast cancer. Methods This retrospective study included female patients with breast cancer. Patients were administered methylene blue and ICG using standard techniques. All SLNs that were collected during surgery were submitted for pathological examination. SLNs were defined as those that were either fluorescent, blue, fluorescent and blue or palpably suspicious...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28414190/engineered-polymeric-microspheres-obtained-by-multi-step-method-as-potential-systems-for-transarterial-embolization-and-intraoperative-imaging-of-hcc-preliminary-evaluation
#11
Elena Piera Porcu, Andrea Salis, Giovanna Rassu, Marcello Maestri, Jacopo Galafassi, Giovanna Bruni, Paolo Giunchedi, Elisabetta Gavini
The aim of this study was the development of novel fluorescent microspheres as embolic agent for transarterial embolization (TAE) of advanced stages of hepatocellular carcinoma (HCC). TAE is a minimally invasive procedure that induces tumour regression blocking the blood flow by injection of microparticles. The microspheres currently used in clinical application cannot be visualized in vivo. Surgeon could exploit the intraoperative detection of embolic agents during resection of the malignant mass. Biocompatible indocyanine green (ICG)-loaded microspheres (CAB-CS-ICG) were prepared using a multi-step method...
April 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28411347/pure-3d-laparoscopic-living-donor-right-hemihepatectomy-in-a-donor-with-separate-right-posterior-and-right-anterior-hepatic-ducts-and-portal-veins
#12
Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Kyung Chul Yoon, Sung-Woo Ahn, Dongkyu Oh, Hyeyoung Kim, Nam-Joon Yi, Kwang-Woong Lee
BACKGROUND: Despite increases in the performance of pure laparoscopic living donor hepatectomy, variations in the bile duct or portal vein have been regarded as relative contraindications to this technique [1-3]. This report describes a donor with separate right posterior and right anterior hepatic ducts and portal veins who underwent pure laparoscopic living donor right hemihepatectomy, integrated with 3D laparoscopy and indocyanine green (ICG) near-infrared fluorescence cholangiography [1, 4, 5]...
April 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28410225/sentinel-lymph-node-mapping-in-endometrial-cancer-a-systematic-review-and-meta-analysis
#13
REVIEW
Hefeng Lin, Zheyuan Ding, Vishnu Goutham Kota, Xiaoming Zhang, Jianwei Zhou
Endometrial cancer is the most frequent tumor in the female reproductive system, while the sentinel lymph node (SLN) mapping for diagnostic efficacy of endometrial cancer is still controversial. This meta-analysis was conducted to evaluate the diagnostic value of SLN in the assessment of lymph nodal involvement in endometrial cancer. Forty-four studies including 2,236 cases were identified. The pooled overall detection rate was 83% (95% CI: 80-86%). The pooled sensitivity was 91% (95% CI: 87-95%). The bilateral pelvic node detection rate was 56% (95% CI: 48-64%)...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409155/preservation-of-myocardial-perfusion-and-function-by-keeping-hypertrophied-heart-empty-and-beating-for-valve-surgery-an-in-vivo-mr-study-of-pig-hearts
#14
Jian Wang, Bo Xiang, Jixian Deng, Hung-Yu Lin, Darren H Freed, Rakesh C Arora, Ganghong Tian
Objectives. Normothermic hyperkalemic cardioplegia arrest (NHCA) may not effectively preserve hypertrophied myocardium during open-heart surgery. Normothermic normokalemic beating perfusion (NNBP), keeping hearts empty-beating, was utilized as an alternative to evaluate its cardioprotective role. Materials and Methods. Twelve hypertrophied pig hearts at 58.6 ± 7.2 days after ascending aorta banding underwent NNBP and NHCA, respectively. Near infrared myocardial perfusion imaging with indocyanine green (ICG) was conducted to assess myocardial perfusion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28408827/photothermal-modulated-drug-delivery-and-magnetic-relaxation-based-on-collagen-poly-%C3%AE-glutamic-acid-hydrogel
#15
Sun-Hee Cho, Ahreum Kim, Woojung Shin, Min Beom Heo, Hyun Jong Noh, Kwan Soo Hong, Jee-Hyun Cho, Yong Taik Lim
Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging and drug delivery because encapsulated diagnostic or therapeutic components in the hydrogel can be used to image or change the microenvironment of the injection site by controlling various stimuli such as enzymes, temperature, pH, and photonic energy. In this study, we developed a novel injectable and photoresponsive composite hydrogel composed of anticancer drugs, imaging contrast agents, bio-derived collagen, and multifaceted anionic polypeptide, poly (γ-glutamic acid) (γ-PGA)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28405261/blocking-of-the-lymphatic-vessel-in-lymphedema
#16
Hisako Hara, Makoto Mihara
Objective: In this case report, we present a case wherein we observed a blocking of lymphatic vessels in indocyanine green lymphography and found a shrunken lymphatic vessel intraoperatively. Methods: We performed indocyanine green lymphography and lymphaticovenous anastomosis on a 77-year-old woman. She had previously undergone right mastectomy and axillary lymph node dissection accompanied by radiotherapy and chemotherapy for right breast cancer. She noticed swelling in the right upper limb 22 years after the surgery and consulted our hospital...
2017: Eplasty
https://www.readbyqxmd.com/read/28405131/indocyanine-green-001-icg-001-attenuates-wnt-%C3%AE-catenin-induces-myocardial-injury-following-sepsis
#17
Nasser Ghaly Yousif, Najah R Hadi, Alaa Manea Hassan
OBJECTIVE: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ β-catenin cell signaling. MATERIALS AND METHODS: Adult (4-6 months) male Albino-Webster mice, their weights ranged from 25 to 30 g, were pretreated with ICG-001 i.p., following cecal ligation and puncture (CLP). Left ventricle (LV) function was assessed using a microcatheter system. Monocyte chemoattractant protein-1 (MCP-1) and cytokines mediators in plasma and myocardium were analyzed by enzyme-linked immunosorbent assay...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28404211/intraoperative-real-time-assessment-of-blood-flow-using-indocyanine-green-angiography-after-anastomoses-in-free-flap-reconstructions
#18
T Eguchi, K Kawaguchi, A Basugi, I Kanai, Y Hamada
No abstract text is available yet for this article.
April 9, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28403743/nonclinical-profile-of-blz-100-a-tumor-targeting-fluorescent-imaging-agent
#19
Julia Parrish-Novak, Kelly Byrnes-Blake, Narine Lalayeva, Stefanie Burleson, Janean Fidel, Rhonda Gilmore, Pamela Gayheart-Walsten, Gregory A Bricker, William J Crumb, K S Tarlo, Stacey Hansen, Valorie Wiss, Errol Malta, William S Dernell, James M Olson, Dennis M Miller
BLZ-100 is a single intravenous use, fluorescent imaging agent that labels tumor tissue to enable more complete and precise surgical resection. It is composed of a chlorotoxin peptide covalently bound to the near-infrared fluorophore indocyanine green. BLZ-100 is in clinical development for intraoperative visualization of human tumors. The nonclinical safety and pharmacokinetic (PK) profile of BLZ-100 was evaluated in mice, rats, canines, and nonhuman primates (NHP). Single bolus intravenous administration of BLZ-100 was well tolerated, and no adverse changes were observed in cardiovascular safety pharmacology, PK, and toxicology studies in rats and NHP...
March 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28403037/characteristics-of-submacular-hemorrhages-in-age-related-macular-degeneration
#20
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim
PURPOSE: The aims of this research are to report the incidence and characteristics of submacular hemorrhage secondary to neovascular age-related macular degeneration (AMD) and to compare the detailed morphologic features of hemorrhages between typical neovascular AMD and polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective observational study included 791 eyes of 791 patients who had newly diagnosed neovascular AMD at a single institution. The incidence and extent of submacular hemorrhage of one disc area or greater were estimated and compared between typical neovascular AMD and PCV...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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