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Indocyanine green

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https://www.readbyqxmd.com/read/29775982/the-supraclavicular-artery-perforator-flap-a-comparative-study-of-imaging-techniques-used-in-preoperative-mapping
#1
Hemin Oathman Sheriff, Kawa Abdullah Mahmood, Nzar Hamawandi, Aram Jamal Mirza, Jawad Hawas, Esther Granell Moreno, Juan Antonio Clavero, Christopher Hankins, Jaume Masia
BACKGROUND:  The supraclavicular artery flap is an excellent flap for head and neck reconstruction. The aim of this study is to assess imaging techniques to define the precise vascular boundaries of this flap. METHODS:  Six imaging techniques were used for supraclavicular artery mapping in 65 cases; handheld Doppler, triplex ultrasound, computed tomography angiography, magnetic resonance angiography, digital subtraction angiography, and indocyanine green angiography...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#2
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29770250/the-usefulness-of-indocyanine-green-during-surgery-for-hypervascular-posterior-fossa-tumors
#3
Takahiro Shinya, Hideki Nagamine, Ken-Ichi Sugawara, Shogo Ishiuchi
Background: Cerebral hemangioblastomas are benign tumors with abundant blood flow that occur mainly in the posterior fossa. Tumor removal en bloc is important in surgical treatment because of the risk of bleeding; however, it is actually rather difficult in practice. Therefore, we propose a surgical strategy for visualizing hypervascular tumors of the posterior fossa utilizing indocyanine green (ICG). Case Description: Case 1 involved a 48-year-old male with a history of von Hippel-Lindau (VHL) disease...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29768269/long-term-results-of-combination-treatment-with-single-dose-ranibizumab-plus-photodynamic-therapy-for-retinal-angiomatous-proliferation
#4
Panagiotis Malamos, Ioannis Tservakis, Menelaos Kanakis, Chrysoula Koutsiouki, Evita Kiskira, Georgios Mylonas, John Lakoumentas, Ilias Georgalas
PURPOSE: To present functional and anatomic outcomes of combination therapy with ranibizumab and photodynamic therapy (PDT) in a series of retinal angiomatous proliferation (RAP) cases. METHODS: A total of 17 eyes of 17 patients with RAP were included. Thirteen eyes were treatment naïve and 4 were already on ranibizumab monotherapy. Combined treatment with single-dose ranibizumab and PDT was performed on all treatment-naïve cases. Follow-up was performed every month for 6-38 months, using optical coherence tomography and indocyanine green angiography when necessary...
May 16, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29767944/theranostic-niosomes-for-efficient-sirna-microrna-delivery-and-activatable-near-infrared-fluorescent-tracking-of-stem-cells
#5
Chuanxu Yang, Shan Gao, Ping Song, Frederik Dagnaes-Hansen, Maria Jakobsen, Jørgen Kjems
RNA interference (RNAi) mediated gene regulation in stem cells offers great potential in regenerative medicine. In this study, we developed a theranostic platform for efficient delivery of small RNAs (siRNA/miRNA) to human mesenchymal stem cells (hMSCs) to promote differentiation, and meanwhile, to specifically label the transfected cells for in vivo tracking purpose. We encapsulated indocyanine green (ICG) in a nonionic surfactant vesicle, termed "niosome", that is mainly composed of a nonionic surfactant sorbitan monooleate (Span 80) and a cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767326/fluorescence-supported-lymphography-and-extended-pelvic-lymph-node-dissection-in-robot-assisted-radical-prostatectomy-a-prospective-randomized-trial
#6
Nina Natascha Harke, Michael Godes, Christian Wagner, Mustapha Addali, Bernhard Fangmeyer, Katarina Urbanova, Boris Hadaschik, Jorn H Witt
PURPOSE: To demonstrate the benefits of fluorescence-supported extended pelvic lymph node dissection (ePLND) compared to regular ePLND in robot-assisted radical prostatectomy. METHODS: 120 patients with intermediate- or high-risk prostate cancer were prospectively randomized (1:1): in the intervention group, indocyanine green (ICG) was injected transrectally into the prostate before docking of the robot. In both groups, ePLND was performed including additional dissection of fluorescent lymph nodes (LN) in the ICG group...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29767320/post-hepatectomy-liver-failure-after-major-hepatic-surgery-not-only-size-matters
#7
Ulrika Asenbaum, Klaus Kaczirek, Ahmed Ba-Ssalamah, Helmut Ringl, Christoph Schwarz, Fredrik Waneck, Fabian Fitschek, Christian Loewe, Richard Nolz
OBJECTIVES: To compare the value of functional future liver remnant (functFLR) to established clinical and imaging variables in prediction of post-hepatectomy liver failure (PHLF) after major liver resection. METHODS: This retrospective, cross-sectional study included 62 patients, who underwent gadoxetic acid enhanced MRI and MDCT within 10 weeks prior to resection of ≥ 4 liver segments. Future liver remnant (FLR) was measured in MDCT using semi-automatic software...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29762775/combination-superficial-temporal-artery-middle-cerebral-artery-bypass-and-m2-m2-reanastomosis-with-trapping-of-a-stented-distal-middle-cerebral-artery-aneurysm-3-dimensional-operative-video
#8
Jan-Karl Burkhardt, Sonia Yousef, Halima Tabani, Arnau Benet, Roberto Rodriguez Rubio, Michael T Lawton
Distal middle cerebral artery (MCA) aneurysms often have non-saccular morphology and cannot be clipped, requiring revascularization and trapping instead. Combination bypasses are needed when 2 arteries exit the aneurysm, and extracranial-intracranial and intracranial-intracranial bypasses can be used. This video demonstrates a combination bypass used to treat a previously stented distal MCA aneurysm with both a superficial temporal artery (STA)-to-MCA bypass and an M2-to-M2 reanastomosis. This 56-yr-old man presented with distal left-sided MCA aneurysm 2 years earlier and attempted stent-assisted coiling was aborted after the aneurysm was perforated with stenting alone...
May 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29760983/performance-of-optoacoustic-and-fluorescence-imaging-in-detecting-deep-seated-fluorescent-agents
#9
Zhenyue Chen, Xosé Luís Deán-Ben, Sven Gottschalk, Daniel Razansky
Fluorescent contrast agents are widely employed in biomedical research. While many studies have reported deep tissue imaging of fluorescent moieties using either fluorescence-based or absorption-based (optoacoustic) imaging systems, no systematic comparison has been performed regarding the actual performance of these imaging modalities in detecting deep-seated fluorescent agents. Herein, an integrated imager combining epi-fluorescence and volumetric optoacoustic imaging capabilities has been employed in order to evaluate image degradation with depth for several commonly-used near-infrared dyes in both modes...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29758975/design-of-liver-functional-reserve-monitor-based-on-three-wavelength-from-ir-to-nir
#10
Fuli Ye, Huimiao Zhan, Guilian Shi
BACKGROUND: The preoperative evaluation of liver functional reserve is very important to determine the excision of liver lobe for the patients with liver cancer. There already exist many effective evaluation methods, but these ones have many disadvantages such as large trauma, complicated process and so on. OBJECTIVE: Therefore, it is essential to develop a fast, accurate and simple detection method of liver functional reserve for the practical application in the clinical engineering field...
May 4, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29755818/retinal-angiomatous-proliferation-multimodal-imaging-characteristics-and-follow-up-with-eye-tracked-spectral-domain-optical-coherence-tomography-of-precursor-lesions
#11
Zafer Öztaş, Jale Menteş
Objectives: To present the multimodal imaging characteristics of precursor retinal angiomatous proliferation (RAP) lesions and follow-up results with eye-tracked spectral-domain optical coherence tomography (SD-OCT). Materials and Methods: Six eyes of 6 patients aged 77.5±5.9 years diagnosed with precursor RAP lesion were included in this prospective observational case series. Best corrected visual acuity (BCVA) measurement and complete ophthalmologic examination were performed for all subjects, as well as fundus photography (FP), fundus autofluorescence (FAF), SD-OCT, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography angiography (OCTA), and their long-term follow-up results are presented...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29754978/risk-stratification-using-a-novel-liver-functional-reserve-score-of-combination-prothrombin-time-international-normalized-ratio-to-albumin-ratio-and-albumin-in-patients-with-hepatocellular-carcinoma
#12
Koichiro Haruki, Hiroaki Shiba, Nobuhiro Saito, Takashi Horiuchi, Yoshihiro Shirai, Yuki Fujiwara, Kenei Furukawa, Taro Sakamoto, Katsuhiko Yanaga
BACKGROUND: Liver function in patients with hepatocellular carcinoma is generally graded according to the Child-Pugh system; however, some variables in the Child-Pugh grade are subjective. We developed a novel, objective score called the prothrombin time-international normalized ratio to albumin ratio. The aim of this study was to evaluate the prognostic value of this new score in patients with hepatocellular carcinoma after hepatic resection. METHODS: The study comprised 199 patients who underwent elective hepatic resection for hepatocellular carcinoma between January 2003 and December 2014...
May 10, 2018: Surgery
https://www.readbyqxmd.com/read/29753852/color-fundus-photography-optical-coherence-tomography-and-fluorescein-angiography-in-diagnosing-polypoidal-choroidal-vasculopathy
#13
Voraporn Chaikitmongkol, Preeyanuch Khunsongkiet, Direk Patikulsila, Mansing Ratanasukon, Nawat Watanachai, Chaisiri Jumroendararasame, Catherine B Mayerle, Ian C Han, Connie J Chen, Pawara Winaikosol, Chutikarn Dejkriengkraikul, Janejit Choovuthayakorn, Paradee Kunavisarut, Neil M Bressler
PURPOSE: To determine sensitivity and specificity of polypoidal choroidal vasculopathy (PCV) diagnosis using color fundus photography (CFP), optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) without indocyanine-green angiography (ICGA). DESIGN: Validity analysis. METHODS: Treatment-naïve eyes with serous/serosanguinous maculopathy undergoing CFP, OCT, FFA and ICGA imaging before treatment at a university-hospital in Thailand (January 2013 to June 2015) were identified...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29751360/intact-intraoperative-fluorescence-angiography-ifa-to-prevent-anastomotic-leak-in-rectal-cancer-surgery-a-randomised-controlled-trial
#14
G Armstrong, J Croft, N Corrigan, J M Brown, V Goh, P Quirke, C Hulme, D Tolan, A Kirby, R Cahill, R O'Connell, D Miskovic, M Coleman, D G Jayne
PURPOSE: Anastomotic leak (AL) is a major complication of rectal cancer surgery. Despite advances in surgical practice, rates of AL have remained static at around 10-15%. The aetiology of AL is multifactorial, but one of the most crucial risk factors, which is mostly under the control of the surgeon, is blood supply to the anastomosis. The MRC/NIHR IntAct study will determine whether assessment of anastomotic perfusion using a fluorescent dye (Indocyanine Green) and near-infrared laparoscopy can minimise the rate of anastomotic leak as compared to conventional white light laparoscopy...
May 11, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29747951/surgery-for-intralobar-pulmonary-sequestration-using-indocyanine-green-fluorescence-navigation-a-case-report
#15
Keiji Yamanashi, Norihito Okumura, Chiaki Nakazono, Tomoaki Matsuoka
A 38-year-old man with bilateral Pryce III intralobar sequestration was admitted. At first, left lower lobectomy and division of the aberrant artery were performed because of continuous hemoptysis after admission. Two months later, we planned a video-assisted thoracoscopic wedge resection of the right sequestration and a division of the 2 aberrant arteries. We chose indocyanine green fluorescence navigation because of the small volume of the right sequestration, with a goal to reduce respiratory functional loss as much as possible...
April 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29747235/pure-laparoscopic-hepatectomy-with-augmented-reality-assisted-indocyanine-green-fluorescence-versus-open-hepatectomy-for-hepatocellular-carcinoma-with-liver-cirrhosis-a-propensity-analysis-at-a-single-center
#16
Tan To Cheung, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Simon Hing Yin Tsang, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
INTRODUCTION: Laparoscopic hepatectomy is considered an acceptable treatment of choice in selected patients with primary hepatocellular carcinoma (HCC). Whether indocyanine green (ICG) immunofluorescence, a new technology, may improve surgery outcomes has yet to be tested. The aim of the present study was to investigate and compare the effect of ICG fluorescence imaging on the outcomes of pure laparoscopic hepatectomy and open hepatectomy for primary HCC with background cirrhosis. METHODS: From January 2015 to June 2016, 20 patients with HCC and liver cirrhosis underwent laparoscopic hepatectomy with ICG immunofluorescence...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29744752/indocyanine-green-mediated-photobiomodulation-on-human-osteoblast-cells
#17
Gamze Bölükbaşı Ateş, Ayşe Ak, Bora Garipcan, Murat Gülsoy
Photobiomodulation (PBM) and photodynamic therapy (PDT) share similar mechanisms but have opposite aims. Increased levels of reactive oxygen species (ROS) in the target tissue in response to light combined photosensitizer (PS) application may lead to cell proliferation or oxidative damage depending on the ROS amount. The purpose of the present study is to investigate the effect of indocyanine green (ICG)-mediated PBM on osteoblast cells by measuring cell viability, proliferation, alkaline phosphatase (ALP) activity, mineralization, and gene expressions of three phenotypic osteoblast markers...
May 9, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29744670/real-time-navigation-system-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-using-projection-mapping-with-indocyanine-green-fluorescence
#18
Masahiro Takada, Megumi Takeuchi, Eiji Suzuki, Fumiaki Sato, Yoshiaki Matsumoto, Masae Torii, Nobuko Kawaguchi-Sakita, Hiroto Nishino, Satoru Seo, Etsuro Hatano, Masakazu Toi
BACKGROUND: Inability to visualize indocyanine green fluorescence images in the surgical field limits the application of current near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node (SLN) biopsy in breast cancer patients. The aim of this study was to evaluate the usefulness of the Medical Imaging Projection System (MIPS), which uses active projection mapping, for SLN biopsy. METHODS: A total of 56 patients (59 procedures) underwent SLN biopsy using the MIPS between March 2016 and November 2017...
May 9, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29744048/icg-easily-detects-not-only-the-segmental-plane-but-also-the-course-and-blood-distribution-of-the-bronchial-artery-case-report
#19
Hidetaka Uramoto, Nozomu Motono
Introduction: Sublobar resection has become an acceptable alternative to lobectomy in patients with early-stage lung cancer. Most notable among these approaches is indocyanine green fluorescence (ICG) imaging. Case presentation: Operative finding showed clear green staining of the left upper lobe, S6, superior pulmonary vein, and inferior PV under fluorescence navigation. Soon, the bronchial artery of right lower bronchus showed clear green staining. Next, the whole right lower bronchus is deeply colored green...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29743794/role-of-indocyanine-green-in-predicting-post-transarterial-chemoembolization-liver-failure-in-hepatocellular-carcinoma
#20
Shalimar, Sushil Jain, Shivanand R Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B Paul, Subrat K Acharya
Background/aim: Post-Transarterial Chemoembolization (TACE) Liver Failure (LF) is common in patients with Hepatocellular Carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of Indocyanine Green (ICG) in prediction of post-TACE LF. Methods: Consecutive HCC patients with Child A/B class, categorized as Barcelona Clinic Liver Cancer (BCLC) staging A/B, were included between August 2012 and July 2014. All underwent ICG dynamics: Plasma Disappearance Rate (PDR) was recorded on the day of TACE...
March 2018: Journal of Clinical and Experimental Hepatology
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