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Indocyanine green

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https://www.readbyqxmd.com/read/27918980/a-case-of-incarcerated-femoral-hernia-with-intestinal-blood-flow-assessment-by-brightfield-full-color-near-infrared-fluorescence-camera-report-of-a-case
#1
Shunjin Ryu, Masashi Yoshida, Hironori Ohdaira, Nobuhiro Tsutsui, Norihiko Suzuki, Eisaku Ito, Keigo Nakajima, Satoru Yanagisawa, Masaki Kitajima, Yutaka Suzuki
INTRODUCTION: Indocyanine green (ICG) fluorescence has been reported for examining intestinal blood flow (IBF), but not in the case of bowel released from entrapment in a femoral hernia. We report the case of a patient with incarcerated obturator femoral hernia in whom the bowel was preserved after evaluation of IBF with ICG fluorescence using a brightfield full-color near-infrared fluorescence camera. PRESENTATION OF CASE: A woman in her 60s was diagnosed with incarcerated femoral hernia and underwent surgery...
November 22, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27918799/noninvasive-in-vivo-multispectral-optoacoustic-imaging-of-apoptosis-in-triple-negative-breast-cancer-using-indocyanine-green-conjugated-phosphatidylserine-monoclonal-antibody
#2
Ravi Kumar Kannadorai, Sunil Kumar Udumala, Yu Wing Kwong Sidney
No abstract text is available yet for this article.
December 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27918633/robust-colloidal-nanoparticles-of-pyrrolopyrrole-cyanines-j-aggregates-with-bright-near-infrared-fluorescence-in-aqueous-media-from-spectral-tailoring-to-bioimaging-application
#3
Cangjie Yang, Xiaochen Wang, Mingfeng Wang, Keming Xu, Chenjie Xu
We report a new class of colloidal nanoparticles called JAGG containing near-infrared fluorescent J-aggregates of pyrrolopyrrole cyanines (PPcys) stabilized by amphiphilic block copolymers in aqueous media. The formation of such JAGG can be tuned by the chemical structure of PPcys, the concentration of the chromophores inside the polymeric nanoparticles and ultrasonic treatment. These JAGG nanoparticles exhibit a narrow emission band at 773 nm, a fluorescence quantum yield comparable to that of indocyanine green, and significantly enhanced photostability that is ideal for long-term bioimaging...
December 5, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27916035/-microsurgical-management-and-outcomes-of-intramedullary-spinal-arteriovenous-malformations-a-report-of-14-cases
#4
L Zhang, W Q Jia, J Yang
Objective: To investigate the clinical features, microsurgical management and outcomes of intramedullary spinal arteriovenous malformations (AVM). Methods: A series of 14 patients (10 male, 4 female; mean age (39.1±17.2) years ranged from 16 to 72 years) with intramedullary spinal AVM who underwent microsurgical treatment from November 2008 to April 2015 in Department of Neurosurgery at Beijing Tiantan Hospital were retrospectively reviewed. The location of the AVM included cervical (n=6), thoracic (n=3), cervicothoracic (n=2), and conus medullaris (n=3)...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27913886/influence-of-vessel-stenosis-on-indocyanine-green-fluorescence-intensity-assessed-by-near-infrared-fluorescence-angiography
#5
Masaki Yamamoto, Hideaki Nishimori, Takashi Fukutomi, Takemi Handa, Kazuki Kihara, Miwa Tashiro, Takayuki Sato, Kazumasa Orihashi
PURPOSE: Although useful for visualizing blood flow during revascularization surgery, the permeability of near-infrared fluorescence (NIR) angiography using indocyanine green (ICG) does not allow for vessel stenosis visualization. We hypothesized that changes in ICG fluorescence intensity reflect vessel stenosis, and evaluated the influence of stenosis on blood flow by ex vivo experimentation. METHODS: The vessel stenosis model comprised a silicon tube, a graft occluder, and artificial blood...
December 2, 2016: Surgery Today
https://www.readbyqxmd.com/read/27913447/comparison-of-oct-angiography-and-indocyanine-green-angiographic-findings-with-subtypes-of-polypoidal-choroidal-vasculopathy
#6
Koji Tanaka, Ryusaburo Mori, Akiyuki Kawamura, Hiroyuki Nakashizuka, Yu Wakatsuki, Mitsuko Yuzawa
PURPOSE: To compare the findings of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV) that was divided into two types: polypoidal choroidal neovascularisation (CNV) and typical PCV (type 2 PCV). METHODS: We studied a retrospective case series of 32 patients with treatment-naïve PCV (24 men, eight women; mean age 65.4 years). PCV was categorised into polypoidal CNV (type 1 PCV) and type 2 PCV based on ICGA findings...
December 2, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27912913/intravitreal-therapies-for-non-neovascular-age-related-macular-degeneration-with-intraretinal-or-subretinal-fluid
#7
M Cuesta-Lasso, A Vieira-Barros, R Dolz-Marco, M J Roig-Revert, J Badal, L Amselem, M Díaz-Llopis, R Gallego-Pinazo
OBJECTIVE: To evaluate the efficacy of intravitreal therapies in cases of atrophic age-related macular degeneration (AMD) with subretinal or intraretinal fluid. METHODS: A retrospective review was made of the clinical charts of patients diagnosed with atrophic AMD with subretinal or intraretinal fluid. Fundus photographs and spectral-domain optical coherence tomography images were examined, and an analysis was made on the presence of fluid and its density. Neovascularisation was ruled out by fluorescein and/or indocyanine green angiography...
November 29, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27909239/affinity-of-indocyanine-green-in-the-detection-of-colorectal-peritoneal-carcinomatosis-the-role-of-enhanced-permeability-and-retention-effect
#8
Alexandre Filippello, Jack Porcheron, Jean Philippe Klein, Michèle Cottier, Gabriele Barabino
Indocyanine green (ICG) is increasingly being used in digestive oncology. In colorectal cancer, ICG can be used to detect lymph node metastasis and hepatic metastasis on the surface of the liver. In peritoneal carcinomatosis, it was previously suspected that the diffusion of ICG in the tumor mass was due to the enhanced permeability and retention effect; however, this phenomenon has not been clearly demonstrated. Using bevacizumab, an antibody directed against vascular endothelial growth factor that consequently inhibits neoangiogenesis, we sought to confirm the mode of ICG diffusion...
November 30, 2016: Surgical Innovation
https://www.readbyqxmd.com/read/27908566/update-of-choroidal-imaging-techniques-past-present-and-future
#9
J Ruiz-Medrano, I Flores-Moreno, R Gutierrez-Bonet, J Chhablani, J M Ruiz-Moreno
The choroid is the middle layer of the eye, a very vascular and pigmented tissue, with its role in several ophthalmological pathologies already having been clearly established. But it was not until the last few years that we have been able to reliably and precisely measure and quantify its shape and thickness. Ultrasound technology and indocyanine green angiography were the first techniques used for the study of the choroid, and they still maintain their use and clinical indications for the diagnosis and management of several pathologies...
November 28, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27905950/use-of-indocyanine-green-and-the-hypereye-system-for-detecting-sentinel-lymph-nodes-in-breast-cancer-within-a-population-of-european-patients-a-pilot-study
#10
Oldřich Coufal, Vuk Fait
BACKGROUND: Certain studies suggest that using indocyanine green (ICG) could be comparable with using radioisotopes (RI) in detecting sentinel lymph nodes (SLNs) in breast cancer. A number of these studies were performed in Asia. The objective of our pilot study was to evaluate within a European population of breast cancer patients the detection rate of SLNs using ICG and the HyperEye system and the concordance in SLNs detected using this method and the standard method involving RI and a gamma probe...
December 1, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27901637/angiographic-evaluation-of-inflammation-in-atopic-keratoconjunctivitis
#11
Bernhard Steger, Vito Romano, Stephen B Kaye
PURPOSE: Grading of disease activity in patients with atopic keratoconjunctivitis (AKC) is limited by intra- and inter-observer variability. The aim of this study was to identify angiographic parameters to help evaluate inflammation and disease activity. METHODS: In 12 patients (4 with active, 2 with inactive AKC, and 6 controls), disease activity were assessed using a validated biomicroscopic grading scale. Imaging of upper tarsal conjunctiva was undertaken using color photography, fluorescein (FA) and indocyanine green angiography (ICGA)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27899040/clinical-role-of-fluorescence-imaging-in-colorectal-surgery-a-review
#12
Ido Mizrahi, Steven D Wexner
Introduction Anastomotic leak (AL) after colorectal surgery is a devastating complication; decreased blood perfusion is an important risk factor. Surgeons rely on subjective measures to assess bowel perfusion. Fluorescence imaging (FI) with indocyanine green (ICG) provides a real-time objective assessment of intestinal perfusion. Areas Covered A Pubmed search using the terms 'fluorescence imaging', 'indocyanine green', 'colon and rectal surgery' was undertaken. Sixteen articles between 2010 to present were identified...
December 5, 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27897297/facile-one-pot-synthesis-of-fe3o4-chitosan-nanospheres-for-mri-and-fluorescence-imaging-guided-chemo-photothermal-combinational-cancer-therapy
#13
Zhifang Gao, Xijian Liu, Yeying Wang, Guoying Deng, Feng Zhou, Qian Wang, Lijuan Zhang, Jie Lu
Multifunctional nanoplatforms that integrate imaging and chemo-photothermal therapy for highly efficient cancer diagnostics and therapeutics have gained great interest in recent years. Herein, we designed and synthesized biodegradable and biocompatible magnetic chitosan nanospheres (Fe3O4@CS) by a facile one-pot synthesis method. Doxorubicin (DOX, an anticancer drug) and indocyanine green (ICG) can be co-loaded into the Fe3O4@CS nanospheres (Fe3O4@CS-ICG/DOX nanocomposites) by virtue of the mesoporous structure and electrostatic interactions of CS...
November 29, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27895581/evaluation-of-near-infrared-dyes-as-markers-of-p-glycoprotein-activity-in-tumors
#14
Inessa Semenenko, Emma Portnoy, Mohammed Aboukaoud, Serge Guzy, Miriam Shmuel, Gal Itzhak, Sara Eyal
Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and with poor patient prognosis. This study evaluated the feasibility of non-invasive, non-radioactive near infrared (NIR) imaging methodology for detection of MDR1 functional activity in tumors. Methods: Initial accumulation assays were conducted in MDR1-overexpressing MDCK cells (MDCK-MDR1) and control MDCK cells (MDCK-CT) using the NIR dyes indocyanine green (ICG), IR-783, IR-775, rhodamine 800, XenoLight DiR, and Genhance 750, at 0...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27895355/prediction-of-asialoglycoprotein-receptors-by-correlated-liver-function-parameters-before-hepatectomy
#15
Wen Jing, Jiang Li, Li Qin Tao, Jia Zhe, Li Bao Liang, Zhang Ke
Flow cytometric analysis of asialoglycoprotein receptor (ASGPR) levels on the surface of hepatocytes, which were obtained from the liver specimens of patients that received hepatectomy, were used as predictors of liver dysfunction after major hepatectomy for primary hepatocellular carcinoma (HCC) in Chinese patients, based on our previous study which confirmed the value of ASGPR levels on the surface of hepatocytes in evaluating the liver reserve function. The current study was planned to establish a conversion formula for the value of ASGPR with correlated liver function parameters...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894812/enhanced-legumain-recognition-and-nir-controlled-released-of-cisplatin-indocyanine-nanosphere-against-gastric-carcinoma
#16
Tianyi Shi, Lianshuai Gu, Yu Sun, Senlin Wang, Chaoqun You, Xiangyang Zhang, Jin Zhu, Baiwang Sun
Cisplatin-therapy has faced limitations in the gastric cancer therapy. To settle the bottleneck, enhanced specificity and controlled-release property are choosen. We synthesize cisplatin and indocyanine green (ICG) loaded PLGA-(DSPE-PEG2000) nanoparticles, which is abbreviated as CINPs. And we conjugate the Gly-Cys-Gly-Ala-Ala-Asn-Leu (GCGAANL) heptapeptide upon the surface of CINPs, the product is abbreviated as ACINPs. ACINPs with nearly 110nm exhibit good monodispersity and size stability. The EE (efficiency of encapsulation) and LE (loading of encapsulation) of cisplatin loaded into ACINPs are optimized as 29...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27894166/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-for-uterine-cervical-cancer-using-99m-technetium-tin-colloid-indocyanine-green-and-blue-dye
#17
Tomohito Tanaka, Yoshito Terai, Keisuke Ashihara, Satoshi Tsunetoh, Hiroyuki Akagi, Takashi Yamada, Masahide Ohmichi
OBJECTIVE: Our objective was to determine the feasibility and detection rates and clarify the most effective combination of injected tracer types for sentinel lymph node (SLN) mapping in uterine cervical cancer in patients who have undergone laparoscopic surgery or neoadjuvant chemotherapy (NAC). METHODS: A total of 119 patients with cervical cancer underwent SLN biopsy at radical hysterectomy using three types of tracers. The various factors related to side-specific detection rate, sensitivity, and false negative (FN) rate were analyzed...
November 1, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27894153/painless-indocyanine-green-lymphography
#18
Giuseppe Visconti, Roberta Albanese, Marzia Salgarello
No abstract text is available yet for this article.
November 28, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27892715/incorporation-of-chemotherapeutic-agent-and-photosensitizer-in-a-low-temperature-sensitive-liposome-for-effective-chemo-hyperthermic-anticancer-activity
#19
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Tung Thanh Pham, Jee-Heon Jeong, Yu Seok Youn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
OBJECTIVES: In this study, we combined chemo- and hyperthermia therapy in a low temperature-sensitive liposome (LTSL) for potential cancer treatment. METHODS: Docetaxel (DOC) and indocyanine green (ICG) as a therapeutic agent and photosensitizer, respectively, were incorporated in a low temperature-sensitive liposome (LTSL/DI). Nanoparticles were evaluated for the physicochemical characterizations, in vitro uptake and cytotoxicity, and furthermore in vivo anticancer activity...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892689/biofilm-inhibitors-targeting-the-outer-membrane-protein-a-of-pasteurella-multocida-in-swine
#20
Anchanee Kubera, Arinthip Thamchaipenet, Menachem Shoham
Pasteurella multocida (Pm) is the causative agent of atrophic rhinitis in swine. This study aimed to discover biofilm inhibitors against swine Pm to counteract antibiotic resistance and decrease virulence. The virulence factor outer membrane protein A (OmpA) was targeted. A library of drugs approved by the Food and Drug Administration (FDA) was used to perform virtual screening against PmOmpA. The top-scoring compounds had no effect on the growth of Pm serotype A or D. Mycophenolate mofetil showed the highest efficacy in inhibiting biofilm formation by Pm serotype A, with an IC50 of 7...
November 28, 2016: Biofouling
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