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Indocyanine green

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https://www.readbyqxmd.com/read/29166345/prepectoral-immediate-direct-to-implant-breast-reconstruction-with-anterior-alloderm-coverage
#1
Glyn Jones, Aran Yoo, Victor King, Brian Jao, Huaping Wang, Charalambos Rammos, Eric Elwood
BACKGROUND: Staged subpectoral expander-implant breast reconstruction is widely performed. Disruption of the pectoralis major origin and the frequent occurrence of animation deformity and functional discomfort associated with subpectoral reconstruction remain ongoing concerns. Prepectoral single-stage direct-to-implant reconstruction resolves many of these issues. In this study, the authors explored the rationale for prepectoral single-stage implant-based breast reconstruction with anterior AlloDerm coverage as an alternative to the staged approach...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29163827/fluorescence-contrast-enhanced-proliferative-lesion-imaging-by-enema-administration-of-indocyanine-green-in-a-rat-model-of-colon-carcinogenesis
#2
Nobuhiko Onda, Reiko Mizutani-Morita, Susumu Yamashita, Rei Nagahara, Shinya Matsumoto, Toshinori Yoshida, Makoto Shibutani
The fluorescent contrast agent indocyanine green (ICG) is approved by the Food and Drug Administration for clinical applications. We previously reported that cultured human colon tumor cells preferentially take up ICG by endocytic activity in association with disruption of their tight junctions. The present study explored ICG availability in fluorescence imaging of the colon to identify proliferative lesions during colonoscopy. The cellular uptake of ICG in cultured rat colon tumor cells was examined using live-cell imaging...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29161627/nanoscaled-red-blood-cells-facilitate-breast-cancer-treatment-by-combining-photothermal-photodynamic-therapy-and-chemotherapy
#3
Guoyun Wan, Bowei Chen, Ling Li, Dan Wang, Shurui Shi, Tao Zhang, Yue Wang, Lianyun Zhang, Yinsong Wang
Red blood cells (RBCs)-based vesicles have been widely used for drug delivery due to their unique advantages. Intact RBCs contain a large amount of oxyhemoglobin (oxyHb), which can assist with photodynamic therapy (PDT). Indocyanine green (ICG), a photosensitizer both for photothermal therapy (PTT) and PDT, shows potent anticancer efficacy when combined with chemotherapeutic drug doxorubicin (DOX). In this study, we prepared nanoscaled RBCs (RAs) containing oxyHb and gas-generating agent ammonium bicarbonate (ABC) for co-loading and controlled release of ICG and DOX, thus hoping to achieve synergistic effects of PTT/PDT and chemotherapy against breast cancer...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29160121/near-infrared-light-responsive-nanoparticles-for-improved-anticancer-efficacy-through-synergistic-chemo-photothermal-therapy
#4
Yanli Li, Bing Xin Xiao, Jie Dong, Yun Liu, Shan Gao, Jie Pang, Zengxian Sun
Combined treatment is more effective than single treatment against most forms of cancer. The synergistic chemo-thermotherapy mediated by nanoparticles has superior advantages of lesser adverse effects as a promising cancer therapy modality. In this study, we report a theranostic carrier system co-encapsulating Doxorubicin (DOX) and Indocyanine green (ICG) into the D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS). Full physicochemical characterization studies of the DOX/ICG-loaded TPGS nanoparticles (TNPs) are performed...
November 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29153028/annals-express-development-of-a-simple-indocyanine-green-measurement-method-using-an-automated-biochemical-analyzer
#5
Yuka Sato, Masanori Seimiya, Toshihiko Yoshida, Yuji Sawabe, Eisaku Hokazono, Susumu Osawa, Kazuyuki Matsushita
Background The indocyanine green (ICG) retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated ICG method that does not require blood sampling before intravenous ICG injections and is applicable to an automated biochemical analyzer. Methods The sera of 471 patients collected before and after intravenous ICG injections and submitted to the clinical laboratory of our hospital were used as samples...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29148891/hyperventilation-and-breath-holding-test-with-indocyanine-green-kinetics-predicts-cerebral-hyperperfusion-after-carotid-artery-stenting
#6
Ichiro Nakagawa, Shohei Yokoyama, Daisuke Wajima, Fumihiko Nishimura, Shuichi Yamada, Hiroshi Yokota, Yasushi Motoyama, Young Su Park, Takeshi Wada, Kimihiko Kichikawa, Hiroyuki Nakase
Cerebral hyperperfusion syndrome (CHS) is a serious complication following carotid artery stenting (CAS), but definitive early prediction of CHS has not been established. Here, we evaluated whether indocyanine green kinetics and near-infrared spectroscopy (ICG-NIRS) with hyperventilation (HV) and the breath-holding (BH) test can predict hyperperfusion phenomenon after CAS. The blood flow index (BFI) ratio during HV and BH was prospectively monitored using ICG-NIRS in 66 patients scheduled to undergo CAS. Preoperative cerebrovascular reactivity (CVR) and the postoperative asymmetry index (AI) were also assessed with single-photon emission computed tomography before and after CAS and the correlation with the BFI HV/rest ratio, BFI BH/rest ratio was evaluated...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29146731/organic-anion-transporting-polypeptide-1b3-as-a-dual-reporter-gene-for-fluorescence-and-magnetic-resonance-imaging
#7
Menq-Rong Wu, Hon-Man Liu, Chen-Wen Lu, Way-Hone Shen, I-Jou Lin, Li-Wen Liao, Yi-You Huang, Ming-Jium Shieh, Jong-Kai Hsiao
Reporter proteins have broad applications in visualizing molecular events at the cellular, tissue and whole-body levels. Transmembrane transporters recognizing specific molecular domains are of particular interest because they enable the migration of signal-source molecules from the extracellular space to the cytoplasm for subsequent application in multimodality imaging. Organic anion-transporting polypeptides (OATPs) have demonstrated their MRI reporter efficacy. We further expanded their use as a dual-modality reporter in MRI and noninvasive in vivo imaging system (IVIS)...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29146267/indocyanine-green-tissue-angiography-affects-anastomotic-leakage-after-esophagectomy-a-retrospective-case-control-study
#8
Ioannis Karampinis, Ulrich Ronellenfitsch, Christina Mertens, Andreas Gerken, Svetlana Hetjens, Stefan Post, Peter Kienle, Kai Nowak
PURPOSE: Optimal perfusion of the gastric conduit during esophagectomy is elementary for the anastomotic healing since poor perfusion has been associated with increased morbidity due to anastomotic leaks. Until recently surgical experience was the main tool to assess the perfusion of the anastomosis. We hypothesized that anastomoses located in the zone of optimal ICG perfusion of the gastric conduit ("optizone") have a reduced anastomotic leakage rate after esophagectomy. METHODS: Indocyanine green (ICG) fluorescence tissue angiography was used to evaluate the anastomotic perfusion in 35 patients undergoing esophagectomy with gastric conduit reconstruction...
November 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29145576/different-filling-patterns-of-the-choriocapillaris-in-fluorescein-and-indocyanine-green-angiography-in-primate-eyes-under-elevated-intraocular-pressure
#9
Naoto Hanyuda, Hideo Akiyama, Yukitoshi Shimoda, Ryo Mukai, Morihiko Sano, Yoichiro Shinohara, Shoji Kishi
Purpose: To investigate the hemodynamics of the choriocapillaris in primate eyes under elevated intraocular pressure. Methods: Indocyanine green angiography (ICGA) and fluorescein angiography (FA) were performed in two monkeys after elevation of the intraocular pressure (IOP) to 35 and 60 mm Hg. Results: ICGA and FA showed no perfusion delays in the choriocapillaris at 35 mm Hg. The slow dye filling at 60 mm Hg made it possible to observe the early phase angiography sequence...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29145331/severe-hemodynamic-instability-after-indocyanine-green-injection-during-off-pump-coronary-artery-bypass-grafting-a-case-report
#10
Qing Zhai, Yun Wang, Ayong Tian
RATIONALE: The increasingly intraoperative use of indocyanine green (ICG) means that it is necessary to be aware of both its advantages and potential adverse effects. PATIENT CONCERNS: A 76-year-old woman developed symptoms of sudden severe hemodynamic instability while undergoing coronary artery bypass grafting with ICG injection to detect the patency of the graft. The main clinical manifestations were a sudden drop in blood pressure and increased heart rate. DIAGNOSES: Severe side effects or allergic reaction of ICG...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144626/super-selective-robot-assisted-partial-nephrectomy-using-near-infrared-flurorescence-versus-early-unclamping-of-the-renal-artery-results-of-a-prospective-matched-pair-analysis
#11
Cecilia Lanchon, Valentin Arnoux, Gaëlle Fiard, Jean-Luc Descotes, Jean-Jacques Rambeaud, Jean-Benjamin Lefrancq, Delphine Poncet, Nicolas Terrier, Camille Overs, Quentin Franquet, Jean-Alexandre Long
INTRODUCTION: Super-selective clamping of tumor-specific segmental arteries was developed to eliminate ischemia of the remnant kidney while limiting hemorrhage during partial nephrectomy. The objective is to evaluate the benefice of super-selective clamping on renal functional outcome, compared to early-unclamping of the renal artery. MATERIALS AND METHODS: From March 2015 to July 2016, data from 30 patients undergoing super-selective robot-assisted PN (RAPN) for a solitary tumor by a single surgeon were prospectively collected...
November 19, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29143240/dynamic-infrared-thermography-dirt-for-assessment-of-skin-blood-perfusion-in-cranioplasty-a-proof-of-concept-for-qualitative-comparison-with-the-standard-indocyanine-green-video-angiography-icga
#12
P Rathmann, C Chalopin, D Halama, P Giri, J Meixensberger, D Lindner
PURPOSE: Complications in wound healing after neurosurgical operations occur often due to scarred dehiscence with skin blood perfusion disturbance. The standard imaging method for intraoperative skin perfusion assessment is the invasive indocyanine green video angiography (ICGA). The noninvasive dynamic infrared thermography (DIRT) is a promising alternative modality that was evaluated by comparison with ICGA. METHODS: The study was carried out in two parts: (1) investigation of technical conditions for intraoperative use of DIRT for its comparison with ICGA, and (2) visual and quantitative comparison of both modalities in a proof of concept on nine patients...
November 15, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29143136/investigation-of-arginine-a-specific-cysteine-proteinase-gene-expression-profiling-in-clinical-porphyromonas-gingivalis-isolates-against-photokilling-action-of-the-photo-activated-disinfection
#13
Maryam Pourhajibagher, Roghayeh Ghorbanzadeh, Abbas Bahador
Porphyromonas gingivalis is a significant root canal pathogen capable of causing endodontic infections, which during their treatment may receive sub-lethal doses of photo-activated disinfection (sPAD). As sPAD can influence microbial virulence, this study was designed to evaluate the effect of sPAD on gene expression level of arginine A-specific cysteine proteinase (rgpA), as one of the underlying virulence factors involved in the development of endodontic infection via P. gingivalis strains. To find out the sPAD against 16 clinical isolates of PAD-resistant P...
November 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29142851/the-use-of-icg-enhanced-fluorescence-for-the-evaluation-of-parathyroid-gland-preservation
#14
REVIEW
Pornpeera Jitpratoom, Angkoon Anuwong
Indocyanine green (ICG) enhanced fluorescence imaging is recent innovation as the "real-time intraoperative imaging" technique. Many clinical studies have been reported in the literature which use different devices and techniques that employ various doses and usages of ICG as a non-specific contrast agent. Several groups have performed studies in endocrine surgery, especially with regards to parathyroid-related outcomes after thyroid and parathyroid surgery. However, there is no consensus on the technical details that should be applied...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142843/intraoperative-real-time-localization-of-parathyroid-gland-with-near-infrared-fluorescence-imaging
#15
REVIEW
Sung Won Kim, Hyoung Shin Lee, Kang Dae Lee
Surgeons have cited difficulties in identifying the parathyroid glands (PG) during thyroidectomy. To overcome the limitation of naked eye, many studies on near-infrared fluorescence imaging of PGs have been introduced and suggested that fluorescence imaging is useful for both localizing PGs and evaluating their function. This imaging technique has been reported in two ways: (I) imaging using a fluorescent material called indocyanine green (ICG); and (II) autofluorescence using intrinsic fluorophores. These innovative and novel techniques are expected to have a significant impact on performing thyroid or parathyroid surgery...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29138701/valsalva-related-subretinal-hemorrhage-as-a-presenting-symptom-of-polypoidal-choroidal-vasculopathy
#16
Yousif Subhi, Torben L Sørensen
Purpose: To describe a case of Valsalva-related subretinal hemorrhage as a presenting symptom of polypoidal choroidal vasculopathy (PCV). The patient refrained from treatment against our best advice, and thus this is also a rare case of the natural course of an untreated PCV. Methods: Case report. Results: A 66-year-old female with a respiratory infection coughed intensely until exhaustion, after which she developed visual symptoms on the right eye...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29135799/peripapillary-pachychoroid-syndrome
#17
Nopasak Phasukkijwatana, K Bailey Freund, Rosa Dolz-Marco, Mayss Al-Sheikh, Pearse A Keane, Catherine A Egan, Sandeep Randhawa, Jay M Stewart, Qingyun Liu, Alex P Hunyor, Allan Kreiger, Aaron Nagiel, Robert Lalane, Mansour Rahimi, Won Ki Lee, Lee Merrill Jampol, David Sarraf
PURPOSE: To describe the features of peripapillary pachychoroid syndrome (PPS), a novel pachychoroid disease spectrum (PDS) entity. METHODS: Medical records of 31 eyes (16 patients) with choroidal thickening associated with intraretinal and/or subretinal fluid in the nasal macula extending from the disk were reviewed (patients with PPS). Choroidal thickness was compared with 2 age-matched cohorts: typical PDS (17 eyes with central serous chorioretinopathy or pachychoroid neovasculopathy) and 19 normal eyes...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29134343/factors-influencing-cerebral-aneurysm-obliteration-and-reliability-of-indocyanine-green-video-angiography
#18
Masayuki Gekka, Naoki Nakayama, Haruto Uchino, Kiyohiro Houkin
BACKGROUND: Indocyanine green video-angiography (ICG-V) is commonly used for intraoperative confirmation of aneurysm obliteration following clipping. However, direct puncture of the aneurysm wall occasionally results in blood leakage in patients for whom ICG-V has indicated complete closure. Therefore, the present study aimed to determine the reliability of ICG-V for confirming complete aneurysm closure, and to elucidate the factors underlying aneurysm obliteration and the occurrence of false-negative ICG-V findings...
November 13, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29134135/polypoidal-choroidal-vasculopathy-on-swept-source-optical-coherence-tomography-angiography-with-variable-interscan-time-analysis
#19
Carl B Rebhun, Eric M Moult, Eduardo A Novais, Carlos Moreira-Neto, Stefan B Ploner, Ricardo N Louzada, ByungKun Lee, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed, Daniela Ferrara
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA)...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29131021/a-novel-color-fluorescence-navigation-system-for-intraoperative-transcutaneous-lymphatic-mapping-and-resection-of-sentinel-lymph-nodes-in-breast-cancer-comparison-with-the-combination-of-gamma-probe-scanning-and-visible-dye-methods
#20
Norihiro Hokimoto, Takeki Sugimoto, Tsutomu Namikawa, Taku Funakoshi, Toyokazu Oki, Maho Ogawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Kazuhiro Hanazaki
BACKGROUND: This study evaluated the clinical efficacy of a novel imaging system (HyperEye Medical System [HEMS]; Mizuho Corp., Tokyo, Japan) that uses the near-infrared (NIR) fluorescence of indocyanine green to analyze sentinel lymph node (SLN) biopsies for the staging of breast cancer. METHODS: This study enrolled 91 patients with histologically confirmed breast cancer that was clinically node negative with a tumor size <3 cm. We compared SLN identification rates between HEMS and conventional methods (gamma probe scanning using a colloidal radioisotope [RI] and a blue dye method) by analyzing the relationships of lymphatic to axillary lesions and SLNs...
November 10, 2017: Oncology
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