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Indocyanine green

Rosa Dolz-Marco, David Sarraf, Vincent Giovinazzo, K Bailey Freund
PURPOSE: To describe multimodal imaging findings of an evolving case of acute posterior multifocal placoid pigment epitheliopathy occurring in a young healthy male. METHODS: Case report of a patient with acute posterior multifocal placoid pigment epitheliopathy including comprehensive systemic and ocular examinations. Ultra-widefield autofluorescence, fluorescein angiography, indocyanine green angiography, and serial optical coherence tomography angiography were performed...
October 18, 2016: Retinal Cases & Brief Reports
Christopher W Mangieri, Jason C McCartt, Matthew A Strode, John E Lowry, Prasad M Balakrishna
BACKGROUND: As hepatic surgery has become safer and more commonly performed, the extent of hepatic resections has increased. When there is not enough expected hepatic reserve to facilitate primary resection of hepatic tumors, a clinical adjunct to facilitating primary resection is portal vein embolization (PVE). PVE allows the hepatic remnant to increase to an appropriate size prior to resection via hepatocyte regeneration; however, PVE is not always successful in facilitating adequate regeneration...
October 17, 2016: Surgical Endoscopy
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
September 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hyewon Chung, Suk Ho Byeon, K Bailey Freund
PURPOSE: To review the literature regarding focal choroidal excavation and show its association with pachychoroid features through case examples. METHODS: The clinical manifestations of focal choroidal excavation are illustrated with various imaging modalities inclusive of fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, spectral domain optical coherence tomography (OCT), enhanced depth imaging OCT, and swept-source OCT...
October 4, 2016: Retina
Saranya C Balasubramaniam, Marco Pellegrini, Giovanni Staurenghi, Jose S Pulido
PURPOSE: To describe the features of choroidal tumors on infrared (IR) imaging and to determine the diagnostic sensitivity and specificity of intratumoral choroidal vascular loops on IR imaging for circumscribed choroidal hemangioma (CCH). METHODS: Infrared and indocyanine green images of CCH, choroidal metastases, and choroidal melanomas were reviewed. The main outcome measure was the presence of intratumoral choroidal vascular loops and tufts on IR images. The secondary outcome measure was the presence of peritumoral vascular expansion on indocyanine green images...
October 4, 2016: Retina
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
October 13, 2016: Gynecologic Oncology
Marine Hitier, Jean-Luc Cracowski, Cynthia Hamou, Christian Righini, Georges Bettega
OBJECTIVE: We evaluated the feasibility and the tolerance of repeated fluorescent indocyanine green angiography in free flap monitoring, and determined the intraoperative predictive values of flap vitality. BACKGROUND: The free flap failure rate has been significantly reduced, but free flap loss still occurs and remains a costly disaster. Repeated clinical examinations are commonly used for flap monitoring, but they can be unreliable because of their subjectivity...
September 10, 2016: Journal of Cranio-maxillo-facial Surgery
Alessandro Della Puppa, Oriela Rustemi, Renato Scienza
BACKGROUND: Indocyanine green video-angiography (ICG-VA) after clipping can be misleading in evaluating aneurysm exclusion when the dye is injected before clipping. This is due to ICG entrapment by the clip blades in the aneurysm dome. METHODS: We examined the intraoperative findings of 7 patients presenting ICG entrapment. In all cases, the clipped aneurysms were opened intraoperatively at the end of the procedure to confirm aneurysm exclusion. RESULTS: In 4 cases ICG entrapment was caused by dye injection before clipping for the surgical strategy, in 3 cases because the clip was repositioned based on ICG-VA findings...
October 12, 2016: World Neurosurgery
Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Abbas Bahador
BACKGROUND: Photo-activated disinfection (PAD) is a novel treatment approach, in which bacteria in the root canal system may be exposed to sub-lethal doses of PAD. Such exposure can affect bacterial survival and virulence features, such as biofilm formation ability. The aim of this study was to evaluate the effects of sub-lethal doses of PAD (sPAD) using indocyanine green (ICG) on load and biofilm formation ability of Porphyromonas gingivalis as an anaerobic bacterium associated with endodontic infection...
October 12, 2016: Photodiagnosis and Photodynamic Therapy
Sung-Pil Joo, Seung-Hoon Jung, Sung-Hyun Kim, Tae-Sun Kim
BACKGROUND: Preservation of the superficial Sylvian veins (SSV) is essential to prevent neurological deficits during Sylvian dissection. We describe an appropriate surgical approach for unruptured middle cerebral artery (MCA) aneurysms to preserve these veins by using indocyanine green videoangiography (ICG-VA). METHODS: Between August 2014 and August 2015, we performed microsurgical clipping for 37 unruptured MCA aneurysms in 36 patients. We classified all the cases into 3 types according to the location between the Sylvian fissure and the SSV...
October 11, 2016: World Neurosurgery
John Y-K Lee, Jayesh P Thawani, John Pierce, Ryan Zeh, Maria Martinez-Lage, Michelle Chanin, Ollin Venegas, Sarah Nims, Kim Learned, Jane Keating, Sunil Singhal
BACKGROUND: Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE: To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and clinical investigations, in order to localize tumors and to potentially identify residual disease. METHODS: Fifteen patients were identified and administered a Food and Drug Administration-approved, NIR contrast agent (Second Window indocyanine green [ICG], 5 mg/kg) before surgical resection...
October 11, 2016: Neurosurgery
Yasuhiro Shibata, Sota Kurihara, Seiji Arai, Haruo Kato, Tomomi Suzuki, Yoshiyuki Miyazawa, Hidekazu Koike, Kazuto Ito, Tetsuya Nakamura, Kazuhiro Suzuki
OBJECTIVES: Microsurgical subinguinal varicocelectomy is one of the best treatment modalities for varicoceles related to male infertility and scrotal pain. However, the difficulty in identifying testicular arteries, which should be spared, is a limitation of this technique. To visualize and identify the testicular arteries in spermatic cord during the operation, we examined the efficacy of intraoperative indocyanine green angiography (ICGA), which is regularly used in microsurgical neurosurgery...
October 13, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Chaoting Zeng, Wenting Shang, Xiaoyuan Liang, Xiao Liang, Qingshan Chen, Chongwei Chi, Yang Du, Chihua Fang, Jie Tian
To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near-infrared ray (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision...
October 12, 2016: ACS Applied Materials & Interfaces
Sunkuk Kwon, Eva M Sevick-Muraca
A local anesthetic, lidocaine, is known to affect cutaneous blood flow when injected into the skin. However, it is unknown if dermal lymphatic function can also be affected. Therefore, we characterized lymphatic function in response to administration of lidocaine with and without epinephrine. Non-invasive near-infrared fluorescence imaging (NIRFI) with intradermal injection of indocyanine green (ICG) was used to characterize the lymphatic "pumping" function in mice after subcutaneous injection of 2 % lidocaine with and without 1:100,000 epinephrine or saline...
October 11, 2016: Journal of Anesthesia
Yumiko Kageyama, Takashi Kokudo, Katsumi Amikura, Yoshihiro Miyazaki, Amane Takahashi, Hirohiko Sakamoto
AIM: To clarify the clinical factors associated with liver regeneration after major hepatectomy and the hypertrophic rate after portal vein embolization (PVE). METHODS: A total of 63 patients who underwent major hepatectomy and 13 patients who underwent PVE in a tertiary care hospital between January 2012 and August 2015 were included in the analysis. We calculated the remnant liver volume following hepatectomy using contrast-enhanced computed tomography (CT) performed before and approximately 3-6 mo after hepatectomy...
October 8, 2016: World Journal of Hepatology
Joham Choque-Velasquez, Roberto Colasanti, Behnam Rezai Jahromi, Juha Hernesniemi
OBJECTIVE: The preservation of normal peri/intralesional bridging veins is extremely important in every microneurosurgical operation. Purpose of our study is to describe the "squeeze maneuver" assisted by indocyanine green videoangiography (ICGV), a simple technique to "resuscitate" partially occluded bridging veins during microneurosurgical operations. METHODS: When a bridging vein is inadvertently stretched up to its collapse during microneurosurgical procedures, a precise identification of the partially occluded zone is carried out under high magnification (10-15x), as well as with the aid of the ICGV...
October 8, 2016: World Neurosurgery
Aniruddha Agarwal, Sarakshi Mahajan, Moncef Khairallah, Padmamalini Mahendradas, Amod Gupta, Vishali Gupta
Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be quite similar. With advancing technology, a number of novel imaging modalities are available today that enable in vivo near-histologic assessment of the chorioretinal tissue, greatly aiding the clinician in establishing a diagnosis and monitoring the therapeutic response of tubercular lesions...
October 11, 2016: Ocular Immunology and Inflammation
Fabio Martinelli, Antonino Ditto, Giorgio Bogani, Mauro Signorelli, Valentina Chiappa, Domenica Lorusso, Edward Haeusler, Francesco Raspagliesi
STUDY OBJECTIVE: To report on detection-rate (DR) of sentinel-nodes (SLNs) in endometrial-cancer (EC) patients after hysteroscopic injection of indocyanine-green (ICG) and Laparoscopic near-infrared (L-NIR) fluorescence mapping. DESIGN: Prospectively collected data. DESIGN: classification: Canadian Task Force II-2 SETTING: Gynecologic oncology referral center. PATIENTS: Consecutive patients with apparent early-stage endometrioid EC scheduled for surgical treatment: total-laparoscopic-hysterectomy, bilateral salpingo-oophorectomy, SLNs mapping...
October 7, 2016: Journal of Minimally Invasive Gynecology
Vladimir A Kuzmin, Tatiana D Nekipelova, Tatyana A Podrugina, Galina V Golovina, Alexey A Kostyukov, Viktor V Temnov, Irina A Doroshenko, Eugene V Radchenko, Vladimir A Palyulin, Nikolay S Zefirov
The spectral characteristics, binding constants with bovine (BSA) and human serum albumin (HSA) and lifetimes of fluorescence in PBS and EtOH solutions and in the presence of BSA in PBS were measured for novel indotricarbocyanine dyes bearing remote phosphonate groups. These parameters are close to those for indocyanine green (ICG) indicating that the Coulomb interaction does not play a significant role in complex formation, and the binding is determined by the interaction of the dye polymethine chain with albumin...
October 3, 2016: Photochemical & Photobiological Sciences
Farzaneh Ghorbani, Neda Attaran-Kakhki, Ameneh Sazgarnia
BACKGROUND: Photodynamic therapy (PDT) and photothermal therapy (PTT) are two known optical remedies of cancer. PTT can be combined with other therapies. One of the limitations of optical therapies is the penetration of light into biological tissues, which reduces its effectiveness due to usage of photosensitizers and PTT agents, which are absorbed in the NIR region that provides the maximum penetration. For instance, Indocyanine green (ICG) serves as a photosensitizer and Gold nanostructures as agents for PTT...
October 5, 2016: Photodiagnosis and Photodynamic Therapy
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