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https://www.readbyqxmd.com/read/29333661/nanocage-therapeutics-prevailing-phagocytosis-and-immunogenic-cell-death-awakens-immunity-against-cancer
#1
Eun Jung Lee, Gi-Hoon Nam, Na Kyeong Lee, Minwoo Kih, Eunee Koh, Yoon Kyoung Kim, Yeonsun Hong, Soyoun Kim, Seung-Yoon Park, Cherlhyun Jeong, Yoosoo Yang, In-San Kim
A growing appreciation of the relationship between the immune system and the tumorigenesis has led to the development of strategies aimed at "re-editing" the immune system to kill tumors. Here, a novel tactic is reported for overcoming the activation-energy threshold of the immunosuppressive tumor microenvironment and mediating the delivery and presentation of tumor neoantigens to the host's immune system. This nature-derived nanocage not only efficiently presents ligands that enhance cancer cell phagocytosis, but also delivers drugs that induce immunogenic cancer cell death...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29328440/methanol-extract-of-guettarda-speciosa-linn-inhibits-the-production-of-inflammatory-mediators-through-the-inactivation-of-syk-and-jnk-in-macrophages
#2
Hien Thi Thu Le, Young-Chang Cho, Sayeon Cho
Guettarda speciosa Linn. (G. speciosa, Rubiaceae) has been used as a traditional medicinal plant in Asia for the treatment of various inflammatory conditions, including cough, fever and maternal postpartum infection. However, the mechanisms underlying the anti‑inflammatory action of G. speciosa extracts have remained elusive. In the present study, the anti‑inflammatory effects of the methanol extract of G. speciosa (MGS) were investigated in murine macrophages by measuring the production of inflammatory mediators and the underlying mechanisms of action by performing immunoblotting analysis of proteins that are potentially involved...
January 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29327282/ziziphus-spina-christi-leaf-extract-pretreatment-inhibits-liver-and-spleen-injury-in-a-mouse-model-of-sepsis-via-anti-oxidant-and-anti-inflammatory-effects
#3
Mohamed A Dkhil, Saleh Al-Quraishy, Ahmed E Abdel Moneim
Sepsis is a systemic response to infection that can result in acute hepatic and splenic damage. Ziziphus spina-christi (L.) is a wild tree used as a medicinal plant by ancient Egyptians. However, little is known about the mechanism underlying its effects on sepsis. The current study investigated the protective effects of a Z. spina-christi leaf extract (ZSCLE) on liver and spleen damage in a male C57BL/6 mouse model of sepsis, induced by cecal ligation and puncture (CLP). Prior to CLP, ZSCLE was administered daily for five consecutive days via oral gavage at doses of 100, 200, or 300 mg/kg...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29321644/cox-2-induces-oncogenic-micro-rna-mir655-in-human-breast-cancer
#4
Mousumi Majumder, Leanna Dunn, Ling Liu, Asma Hasan, Krista Vincent, Muriel Brackstone, David Hess, Peeyush K Lala
We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression positively correlated with COX-2 in genetically disparate breast cancer cell lines and increased in all cell lines when grown as spheroids, implicating its link with stem-like cells (SLCs). Ectopic miR655 over-expression in MCF7 and SKBR3 cells resulted in increased proliferation, migration, invasion, spheroid formation and Epithelial to Masenchymal transition (EMT)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320407/biodistribution-and-clearance-of-stable-superparamagnetic-maghemite-iron-oxide-nanoparticles-in-mice-following-intraperitoneal-administration
#5
Binh T T Pham, Emily K Colvin, Nguyen T H Pham, Byung J Kim, Emily S Fuller, Elizabeth A Moon, Raphael Barbey, Samuel Yuen, Barry H Rickman, Nicole S Bryce, Stephanie Bickley, Marcel Tanudji, Stephen K Jones, Viive M Howell, Brian S Hawkett
Nanomedicine is an emerging field with great potential in disease theranostics. We generated sterically stabilized superparamagnetic iron oxide nanoparticles (s-SPIONs) with average core diameters of 10 and 25 nm and determined the in vivo biodistribution and clearance profiles. Healthy nude mice underwent an intraperitoneal injection of these s-SPIONs at a dose of 90 mg Fe/kg body weight. Tissue iron biodistribution was monitored by atomic absorption spectroscopy and Prussian blue staining. Histopathological examination was performed to assess tissue toxicity...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29317734/combined-sep-and-anti-pd-l1-antibody-produces-a-synergistic-antitumor-effect-in-b16-f10-melanoma-bearing-mice
#6
Zhengping Hu, Liang Ye, Yingying Xing, Jinhang Hu, Tao Xi
The increased PD-L1 induces poorer prognosis in melanoma. The treatment with PD-1/PD-L1 antibodies have a low response rate. The combination immunotherapies are the encouraging drug development strategy to receive maximal therapeutic benefit. In this study, we investigated the enhanced antitumor and immunomodulatory activity of combined SEP and αPD-L1 in B16-F10 melanoma-bearing mice. The results shown that combined SEP and αPD-L1 presented significant synergistic antitumor effects, increased the frequency of CD8+ and CD4+ T cells in spleen and tumor, cytotoxic activity of CTL in spleen, and IL-2 and IFN-γ levels in splenocytes and tumor...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317289/baroreflex-stimulation-attenuates-central-but-not-peripheral-inflammation-in-conscious-endotoxemic-rats
#7
Fernanda Brognara, Jaci A Castania, Daniel P M Dias, Alexandre H Lopes, Rubens Fazan, Alexandre Kanashiro, Luis Ulloa, Helio C Salgado
We previously reported that activation of the baroreflex, a critical physiological mechanism controlling cardiovascular homeostasis, through electrical stimulation of the aortic depressor nerve attenuates joint inflammation in experimental arthritis. However, it is unknown whether baroreflex activation can control systemic inflammation. Here, we investigate whether baroreflex activation controls systemic inflammation in conscious endotoxemic rats. Animals underwent sham or electrical aortic depressor nerve stimulation initiated 10 min prior to a lipopolysaccharide (LPS) challenge, while inflammatory cytokine levels were measured in the blood, spleen, heart and hypothalamus 90 min after LPS treatment...
January 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29317237/antitumor-immunostimulatory-activity-of-polysaccharides-from-panax-japonicus-c-a-mey-roles-of-their-effects-on-cd4-t-cells-and-tumor-associated-macrophages
#8
Guangwen Shu, Shanqing Jiang, Jun Mu, Huifan Yu, Huan Duan, Xukun Deng
In this study, chemical properties of polysaccharides from rhizomes of Panax japonicus C. A. Mey (PSPJ) were investigated and the antitumor immunostimulatory activity of PSPJ was assessed in mice bearing H22 hepatoma cells. Chemical properties of PSPJ were determined by GC, FT-IR, 1H NMR and 13C NMR analysis. Furthermore, we showed that PSPJ repressed H22 tumor growth in vivo with undetectable toxic effects on tumor-bearing mice. PSPJ upregulated host thymus/spleen indexes and ConA/LPS-induced splenocyte proliferation...
January 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29315138/peptide-receptor-radionuclide-therapy-with-177lu-dota-octreotate-dosimetry-nephrotoxicity-and-the-effect-of-hematological-toxicity-on-survival
#9
Anastassia Löser, Sarah M Schwarzenböck, Martin Heuschkel, Holger S Willenberg, Bernd J Krause, Jens Kurth
OBJECTIVES: Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-DOTATATE is regarded as a safe treatment option with promising results for patients with neuroendocrine neoplasia (NEN). We aimed to study the absorbed organ and tumor doses, the renal and hematological toxicity as well as their mutual interaction. Another aim was the identification of adverse effects as possible predictors which may affect survival. METHODS: A total of 30 (14 female and 16 male) patients with inoperable/metastatic NEN were treated with 7...
January 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29314858/panitumumab-modified-with-metal-chelating-polymers-mcp-complexed-to-111in-and-177lu-an-egfr-targeted-theranostic-for-pancreatic-cancer
#10
Sadaf Aghevlian, Yijie Lu, Mitchell A Winnik, David W Hedley, Raymond M Reilly
A metal-chelating polymer (MCP) with a polyglutamide (PGlu) backbone presenting on average 13 DOTA (tetraazacyclododecane-1,4,7,10-tetraacetic acid) chelators for complexing 111In or 177Lu and 10 polyethylene glycol (PEG) chains to minimize liver and spleen uptake was conjugated to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), panitumumab. Since panitumumab-MCP may be dual-labeled with 111In and 177Lu for SPECT, or radioimmunotherapy (RIT) exploiting the Auger electrons or β-particle emissions, respectively, we propose that panitumumab-MCP could be a useful theranostic agent EGFR-positive PnCa...
January 9, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29311431/evaluation-of-ph-sensitive-fusogenic-polymer-modified-liposomes-co-loaded-with-antigen-and-%C3%AE-galactosylceramide-as-an-anti-tumor-vaccine
#11
Seiji Okazaki, Tadashi Iwasaki, Eiji Yuba, Shinobu Watarai
pH-Sensitive fusogenic polymer-modified (pH-sensitive) liposomes co-loaded with tumor model antigen, ovalbumin (OVA), and adjuvant, α-galactosylceramide (α-GalCer) were fabricated and administered subcutaneously into mice. The ability of pH-sensitive liposomes containing OVA and α-GalCer to stimulate cellular and humoral immune responses in vivo was compared with OVA-encapsulating pH-sensitive liposomes as well as with OVA alone. After immunization, significant OVA-specific antibodies were detected in the serum...
December 28, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29307624/classic-hodgkin-lymphoma-with-osseous-involvement-mimicking-langerhans-cell-histiocytosis-in-a-child
#12
Kazuhiko Kuwahara, Ko Kudo, Akiko Yashima-Abo, Kosuke Katayama, Keiko Kojima, Kiyoshi Tone, Etsuro Ito, Atsuko Nakazawa, Hideto Iwafuchi, Akira Kurose
Hodgkin lymphoma (HL) commonly presents the superficial lymphadenopathy. In addition, HL cells can arise in various organs including the liver and spleen as an extranodal lymphoma. HL in bone is unusual at the initial diagnosis, although some cases show late stage localization of lymphoma cells to bone. We report the rare case of a young patient with cranial bone classic HL, presumably originating from the skull without any involvement of lymph nodes. As the main clinical manifestation was only tumor mass in the skull without osteoscopic pain, the tentative diagnosis of Langerhans cell histiocytosis was histologically confirmed by an excisional biopsy...
January 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29301578/notch1-signaling-in-melanoma-cells-promoted-tumor-induced-immunosuppression-via-upregulation-of-tgf-%C3%AE-1
#13
Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo, Shijun Kang
BACKGROUND: The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling upon immune suppression induced by melanoma cells. METHODS: Melanoma cell line B16 cells were transfected by lentivirus containing mouse Notch1 gene or Notch1 shRNA to generate B16 cell line that highly or lowly expressed Notch1. Notch1 in anti-tumor immune response was comprehensively appraised in murine B16 melanoma tumor model in immunocompetent and immunodeficient mice...
January 4, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29301108/mesenchymal-stromal-cells-inhibit-inflammatory-lymphangiogenesis-in-the-cornea-by-suppressing-macrophage-in-a-tsg-6-dependent-manner
#14
Hyun Beom Song, Se Yeon Park, Jung Hwa Ko, Jong Woo Park, Chang Ho Yoon, Dong Hyun Kim, Jeong Hun Kim, Mee Kum Kim, Ryang Hwa Lee, Darwin J Prockop, Joo Youn Oh
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials in a variety of diseases because of anti-inflammatory properties. Herein, we investigated the effects of MSCs on corneal angiogenesis using a model of suture-induced inflammatory corneal neovascularization. Data demonstrated that an intravenous administration of MSCs suppressed corneal inflammation and neovascularization, inhibiting both hemangiogenesis and lymphangiogenesis...
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29299117/a-new-bioluminescent-reporter-system-to-study-the-biodistribution-of-systematically-injected-tumor-derived-bioluminescent-extracellular-vesicles-in-mice
#15
Prakash Gangadaran, Xiu Juan Li, Ho Won Lee, Ji Min Oh, Senthilkumar Kalimuthu, Ramya Lakshmi Rajendran, Seung Hyun Son, Se Hwan Baek, Thoudam Debraj Singh, Liya Zhu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed and applied to monitoring of EVs derived from thyroid cancer (CAL-62 cells) and breast cancer (MDA-MB-231) in nude mice after intravenous administration and was compared with a dye-based labeling method for EV derived from CAL-62 cells. The EVs were successfully labeled with Rluc and visualized by BLI in mice...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299089/hamartoma-of-the-spleen-splenoma-with-calcifications-in-a-child-with-beta-thalassemia-a-case-report
#16
Dario Giambelluca, Dario Picone, Giuseppe Lo Re, Salvatore Pappalardo, Placido Romeo
Splenic hamartoma (or splenoma) is a rare, benign, vascular tumor, often incidentally found at imaging, surgery or autopsy. Albeit usually asymptomatic and rare in children, when it occurs in the pediatric population it is more commonly symptomatic. We report a case of a 15-year-old girl with iron-deficiency anemia and beta-thalassemia, who had a large (10 × 8 × 7 cm) splenic lesion with calcifications, incidentally found during follow-up for splenomegaly and histologically characterized as hamartoma with calcified areas...
May 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29296731/human-and-murine-splenic-neutrophils-are-potent-phagocytes-of-igg-opsonized-red-blood-cells
#17
Sanne M Meinderts, Per-Arne Oldenborg, Boukje M Beuger, Thomas R L Klei, Johanna Johansson, Taco W Kuijpers, Takashi Matozaki, Elise J Huisman, Masja de Haas, Timo K van den Berg, Robin van Bruggen
Red blood cell (RBC) clearance is known to occur primarily in the spleen, and is presumed to be executed by red pulp macrophages. Erythrophagocytosis in the spleen takes place as part of the homeostatic turnover of RBCs to remove old RBCs. It can be strongly promoted by immunoglobulin G (IgG) opsonization of RBCs, a condition that can occur as a consequence of autoantibody or alloantibody formation. The purpose of our study was to investigate which phagocytes are involved in IgG-mediated RBC clearance in the human spleen...
June 13, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290958/stromal-annexin-a2-expression-is-predictive-of-decreased-survival-in-pancreatic-cancer
#18
Adrian G Murphy, Kelly Foley, Agnieszka A Rucki, Tao Xia, Elizabeth M Jaffee, Chiung-Yu Huang, Lei Zheng
Pancreatic ductal adenocarcinoma (PDA) is renowned for high rates of metastasis and poor survival. Its notoriously dense fibrotic stroma contributes to chemoresistance. Stromal signaling in PDA is recognized for its multiple roles in regulating tumor invasion and metastasis. However, no stromal biomarker which can predict survival in PDA exists. Annexin A2 (AnxA2) was formerly identified as a metastasis-associated protein in PDA and tumoral overexpression is associated with poor survival. In this study, we examined AnxA2 expression in the tumor microenvironment in a preclinical model of PDA which suggests its role in tumor colonization...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290653/pharmacokinetics-and-pharmacodynamics-of-shengjiang-decoction-in-rats-with-acute-pancreatitis-for-protecting-against-multiple-organ-injury
#19
Lv Zhu, Jun-Yi Li, Yu-Mei Zhang, Hong-Xin Kang, Huan Chen, Hang Su, Juan Li, Wen-Fu Tang
AIM: To explore the pharmacokinetics and pharmacodynamics of Shengjiang decoction (SJD) in rats with acute pancreatitis (AP) for protecting against multiple organ injury. METHODS: An AP model was established by retrograde perfusion of 3.5% sodium taurocholate into the biliopancreatic duct, and a control group (CG) received 0.9% sodium chloride instead. Twelve male Sprague-Dawley rats were randomly divided into a CG treated with SJD (CG + SJD) and a model group treated with SJD (MG + SJD), both of which were orally administered with SJD (5 g/kg) 2 h after surgery...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29289711/lipopolysaccharide-induces-tumor-necrosis-factor-receptor-1-independent-relocation-of-lymphocytes-from-the-red-pulp-of-the-mouse-spleen
#20
Ivana M Lalić, Rudolf Bichele, Anja Repar, Sanja Z Despotović, Saša Petričević, Martti Laan, Pärt Peterson, Jürgen Westermann, Živana Milićević, Ivana Mirkov, Novica M Milićević
It is well known that bacterial lipopolysaccharide (LPS) induces migration of several cellular populations within the spleen. However, there are no data about the impact of LPS on B and T lymphocytes present in the red pulp. Therefore, we used an experimental model in which we tested the effects of intravenously injected LPS on the molecular, cellular and structural changes of the spleen, with special reference to the red pulp lymphocytes. We discovered that LPS induced a massive relocation of B and T lymphocytes from the splenic red pulp, which was independent of the tumor necrosis factor receptor-1 signaling axis...
December 28, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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