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Methane levels in stool

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https://www.readbyqxmd.com/read/27458176/irritable-bowel-syndrome-particularly-the-constipation-predominant-form-involves-an-increase-in-methanobrevibacter-smithii-which-is-associated-with-higher-methane-production
#1
Ujjala Ghoshal, Ratnakar Shukla, Deepakshi Srivastava, Uday C Ghoshal
Background/Aims: Because Methanobrevibacter smithii produces methane, delaying gut transit, we evaluated M. smithii loads in irritable bowel syndrome (IBS) patients and healthy controls (HC). Methods: Quantitative real-time polymerase chain reaction for M. smithii was performed on the feces of 47 IBS patients (Rome III) and 30 HC. On the lactulose hydrogen breath test (LHBT, done for 25 IBS patients), a fasting methane result ≥10 ppm using 10 g of lactulose defined methane-producers...
July 27, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27080737/psyllium-fiber-reduces-abdominal-pain-in-children-with-irritable-bowel-syndrome-in-a-randomized-double-blind-trial
#2
Robert J Shulman, Emily B Hollister, Kevin Cain, Danita I Czyzewski, Mariella M Self, Erica M Weidler, Sridevi Devaraj, Ruth Ann Luna, James Versalovic, Margaret Heitkemper
BACKGROUND & AIMS: We sought to determine the efficacy of psyllium fiber treatment on abdominal pain and stool patterns in children with irritable bowel syndrome (IBS). We evaluated effects on breath hydrogen and methane production, gut permeability, and microbiome composition. We also investigated whether psychological characteristics of children or parents affected the response to treatment. METHODS: We performed a randomized, double-blind trial of 103 children (mean age, 13 ± 3 y) with IBS seen at primary or tertiary care settings...
April 11, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26833719/metabolic-effects-of-eradicating-breath-methane-using-antibiotics-in-prediabetic-subjects-with-obesity
#3
Ruchi Mathur, Kathleen S Chua, Mindy Mamelak, Walter Morales, Gillian M Barlow, Rita Thomas, Darko Stefanovski, Stacy Weitsman, Zachary Marsh, Richard N Bergman, Mark Pimentel
OBJECTIVE: Methanogens colonizing the human gut produce methane and influence host metabolism. This study examined metabolic parameters in methane-producing subjects before and after antibiotic treatment. METHODS: Eleven prediabetic methane-positive subjects (9F, 2M) with obesity (BMI 35.17 ± 7.71 kg/m(2) ) aged 47 ± 9 years were recruited. Subjects underwent breath testing, symptom questionnaire, oral glucose tolerance test (OGTT), lipid profile, and stool Methanobrevibacter smithii levels, gastric transit, and energy utilization analyses...
March 2016: Obesity
https://www.readbyqxmd.com/read/26278025/breath-hydrogen-and-methane-are-associated-with-intestinal-symptoms-in-patients-with-chronic-pancreatitis
#4
Dae Bum Kim, Chang-Nyol Paik, Hea Jung Sung, Woo Chul Chung, Kang-Moon Lee, Jin-Mo Yang, Myung-Gyu Choi
BACKGROUNDS: The bacterial overgrowth might be associated with chronic pancreatitis. This study was to evaluate the prevalence and characteristics of small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis. METHODS: 36 patients with chronic pancreatitis and 49 healthy controls undergoing the hydrogen (H2)-methane (CH4) lactulose breath test (LBT) were reviewed. The LBT positivity (+) indicating the presence of SIBO, gas types, bowel symptom questionnaire, laboratory and radiologic results were surveyed...
September 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/25635640/the-networks-of-human-gut-microbe-metabolite-associations-are-different-between-health-and-irritable-bowel-syndrome
#5
Vijay Shankar, Daniel Homer, Laura Rigsbee, Harry J Khamis, Sonia Michail, Michael Raymer, Nicholas V Reo, Oleg Paliy
The goal of this study was to determine if fecal metabolite and microbiota profiles can serve as biomarkers of human intestinal diseases, and to uncover possible gut microbe-metabolite associations. We employed proton nuclear magnetic resonance to measure fecal metabolites of healthy children and those diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D). Metabolite levels were associated with fecal microbial abundances. Using several ordination techniques, healthy and irritable bowel syndrome (IBS) samples could be distinguished based on the metabolite profiles of fecal samples, and such partitioning was congruent with the microbiota-based sample separation...
August 2015: ISME Journal
https://www.readbyqxmd.com/read/25617726/gut-microbial-and-short-chain-fatty-acid-profiles-in-adults-with-chronic-constipation-before-and-after-treatment-with-lubiprostone
#6
Dae-Wook Kang, John K DiBaise, Zehra Esra Ilhan, Michael D Crowell, Jai Ram Rideout, J Gregory Caporaso, Bruce E Rittmann, Rosa Krajmalnik-Brown
Identifying specific gut microorganisms associated with chronic constipation may be useful for diagnostic and therapeutic purposes. The objective of this study was to evaluate whether or not the gut microbial community of constipated subjects had specific microbial signatures and to assess the effects of lubiprostone treatment on the gut microbial community. Stool diaries, breath H2 and CH4 levels, and stool samples were collected from ten healthy subjects and nine patients meeting the Rome III criteria for chronic functional constipation...
June 2015: Anaerobe
https://www.readbyqxmd.com/read/24247567/the-prevalence-of-small-intestinal-bacterial-overgrowth-and-methane-production-in-patients-with-myelomeningocele-and-constipation
#7
V Ojetti, G Bruno, V Paolucci, S Triarico, F D'aversa, E Ausili, A Gasbarrini, C Rendeli
STUDY DESIGN: Prospective study. OBJECTIVES: The objective of this study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO), methane (CH4) production and orocecal transit time (OCTT) in children affected by myelomeningocele. SETTING: This study was conducted at the Catholic University in Rome, Italy. METHODS: Eighteen (6M/12F; 16.4±7.6 years) children affected by myelomeningocele were enrolled...
January 2014: Spinal Cord
https://www.readbyqxmd.com/read/15963794/development-of-methods-for-the-detection-and-quantification-of-7alpha-dehydroxylating-clostridia-desulfovibrio-vulgaris-methanobrevibacter-smithii-and-lactobacillus-plantarum-in-human-feces
#8
Jason M Ridlon, Sean E McGarr, Phillip B Hylemon
BACKGROUND: Mounting evidence suggests a relationship between bacterial metabolism of certain dietary and endogenous factors and the development of colorectal cancer. Deoxycholic acid (DCA) is a well studied co-carcinogen and bio-transformation product of 7alpha-dehydroxylating Clostridia. H2S is a cytotoxic metabolite produced primarily by sulfate-reducing bacteria (SRB). The production of methane indicates low levels of active SRB. Lactic acid bacteria (LAB) have received attention recently due to their putative anti-tumor properties...
July 1, 2005: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/14560998/colonic-hydrogen-elimination-and-methane-production-in-infants-with-and-without-infantile-colic-syndrome
#9
Amir Belson, Avinash K Shetty, Peter D Yorgin, Yoram Bujanover, Yochanan Peled, Mor H Dar, Shimon Reif
Our objective was to investigate the relationship between demographic factors, nutrition, stool gas production, and the existence of infantile colic (IC) syndrome. Hydrogen and methane production from stool specimens of infants with and without infantile colic was quantified at two separate time points, the age at presentation of colic (<12 weeks) and at >6 months of age. The relationship between demographic variables and IC was also studied. A total of 59 infants with ages ranging from 2 to 12 weeks were enrolled in the study...
September 2003: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/10522609/low-trehalase-activity-is-associated-with-abdominal-symptoms-caused-by-edible-mushrooms
#10
H Arola, T Koivula, A L Karvonen, H Jokela, T Ahola, M Isokoski
BACKGROUND: The purpose of the study was to evaluate whether maldigestion of trehalose causes abdominal symptoms and which available diagnostic method best distinguishes intolerant from tolerant subjects. METHODS: A 25-g oral trehalose load test was performed in 64 subjects. The 19 experiencing clear symptoms constituted the trehalose-intolerant subjects. Changes from base-line levels of blood glucose, breath hydrogen, and methane and symptoms were recorded after the test...
September 1999: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/2823871/the-effect-of-age-sex-and-level-of-intake-of-dietary-fibre-from-wheat-on-large-bowel-function-in-thirty-healthy-subjects
#11
A M Stephen, H S Wiggins, H N Englyst, T J Cole, B J Wayman, J H Cummings
1. To evaluate the effect of age, sex and level of intake on the colonic response to wheat fibre, thirty healthy volunteers aged 17-62 years (nineteen men, eleven women) recruited from a local industry, were divided into four groups and given a controlled diet for two 3-week periods. The diet contained white bread during one period or one of four different amounts of bran-enriched wholemeal bread during the other (30, 60, 110, 170 g/d). 2. Wide variation was observed between subjects in stool weight on the basal diet and in response to wheat fibre...
September 1986: British Journal of Nutrition
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