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Septal defect

Xiaoke Shang, Rong Lu, Nianguo Dong
This is the first attempt to use a temporary occluder to close a giant perimembranous ventricular septal defect (32 mm), which obtains clinical evidence of good haemodynamics in patients with severe pulmonary hypertension. This may provide an alternative assessment to guide cardiac surgeons in determining a definitive treatment.
June 20, 2018: Cardiology in the Young
Amélie Pinard, Nathalie Eudes, Julia Mitchell, Fanny Bajolle, Maude Grelet, Joséphine Okoronkwo, Damien Bonnet, Gwenaelle Collod-Béroud, Stéphane Zaffran
Ventricular septal defect (VSD) including outlet VSD of double outlet right ventricle (DORV) and perimembranous VSD are among the most common congenital heart diseases found at birth. HOXB1 encodes a homeodomain transcription factor essential for normal cardiac outflow tract development. The aim of the present study was to investigate the possible genetic effect of sequence variations in HOXB1 on VSD. The coding regions and splice junctions of the HOXB1 gene were sequenced in 57 unrelated VSD patients. As a result, a homozygous c...
June 19, 2018: Molecular Biology Reports
Maha Jahangir, Marrium Nawaz, Fareha Jabbar, Fahad Khan, Nimra Hasnain
Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, intravenous drug abuse (IVDA) is a potential cause for IE. IE remains a diagnostic and therapeutic challenge. Our case report demonstrates the atypical presentation of IE in an ASD patient. The diagnosis was made on the basis of modified Duke criteria, and blood cultures were found out to be positive for methicillin-resistant Staphylococcus aureus (MRSA)...
April 15, 2018: Curēus
Michael Weidenbach, Bardo Wannenmacher, Christian Paech, Robert Wagner
Congenital diveticula and aneurysm of the heart are rare and most often located at the apex of the left ventricle. They pose a significant risk for cardiac failure and arrhythmias. In contrast, nonapical diverticula of the right ventricle (RV) have a much more benign course. We present a child with Trisomy 21, atrioventricular septal defect, and large nonapical diverticulum of the RV that was neither addressed during surgery nor needed any medical treatment during 1-year follow-up.
May 2018: Annals of Pediatric Cardiology
Akshay Chauhan, Saket Agarwal, Utsav Gupta, Nayem Raja, Muhammad Abid Geelani, Vijay Trehan
A case of the right pulmonary artery-to- left atrial fistula with atrial septal defect (ASD) is presented. The fistula was detected after the patient developed desaturation following surgical closure of the ASD. It was managed with a transcatheter (trans-RPA route) closure of the fistula using a 12-mm Amplatzer ventricular septal defect closure device.
May 2018: Annals of Pediatric Cardiology
Yasser Ahmad Bhat, Himanshu Pratap, Kulbhushan Singh Dagar, Neeraj Awasthy
The clinical detail, echocardiographic features, angiographic evaluation, and surgical repair of double-outlet left atrium (LA) in a 2-year-old boy are discussed. In a solitus position and normally connected systemic and pulmonary venous drainage setting, the only outlet of the right atrium was a secundum atrial septal defect. The LA thus received the entire venous return and then drained into both ventricles through a common atrioventricular valve.
May 2018: Annals of Pediatric Cardiology
Avnish Tripathi, Yinding Wang, Jeanette M Jerrell
Background: We investigated the treated prevalence of bicuspid aortic valve in a pediatric population with congenital heart disease and its incident complications. Materials and Methods: A 15-year retrospective data set was analyzed. Selection criteria included age ≤17 years, enrollees in the South Carolina State Medicaid program and diagnosed as having bicuspid aortic valve on one or more service visits. Results: The 15-year-treated prevalence of predominantly isolated bicuspid aortic valve was 2% (20/1000) of pediatric congenital heart disease cases, with a non-African American: African-American ratio of 3...
May 2018: Annals of Pediatric Cardiology
Shivanand Gangahanumaiah, Bronwyn C Scarr, Mark R Buckland, David V Pilcher, Miranda A Paraskeva, David C McGiffin
A 27-year-old female with Eisenmenger's syndrome underwent closure of a patent ductus arteriosus, closure of a perimembranous ventricular septal defect and mid muscular defect and bilateral lung transplantation. Her immediate postoperative course was complicated by severe right ventricular outflow tract (RVOT) obstruction resulting in hemodynamic collapse, a condition described as suicide right ventricle. The patient was placed on central Veno-Arterial Extra-Corporeal Membrane Oxygenation as a bridge to the relief of RVOT obstruction which included a right ventricular outflow muscle resection and a right ventricle outflow tract patch...
June 19, 2018: Journal of Cardiac Surgery
Aziz Inan Celik, Firat Ikikardes, Muhammed Bugra Karaaslan
Partial ventricular septal defect (VSD) (Pacman heart) is extremely rare heart defect which may be a complication of myocardial infarction or congenital deformity. In this image, a 65-year-old male patient admitted with headache and blood pressure dysregulation. Incidentally, transthoracic two-dimensional echocardiography revealed partial VSD which was ensuingly confirmed in thoracic computed tomography. This is the fourth case in light of current literature. Partial VSDs are clinically silent, which can be diagnosed with echocardiography, computed tomography, or cardiac magnetic resonance imaging modalities...
June 19, 2018: Echocardiography
B Sunil Abhishek, Anupam Bhambhani
Ischaemic stroke is among the leading causes of disability and death. Despite extensive vascular, cardiac and serological evaluations, the cause remains unknown in 20%-40% of patients. These are classified as cryptogenic stroke. Paradoxical embolism is one of the many causes of cryptogenic stroke. The term paradoxical embolism is used to describe an embolus of venous origin entering the systemic circulation through a patent foramen ovale (PFO), atrial septal defect (ASD), ventricular septal defect or extracardiac communication such as pulmonary arteriovenous malformation...
September 2017: National Medical Journal of India
Alberto Cresti, Massimiliano Cantinotti, Stefania Stefanelli, Marco Solari, Incoronata D'Aiello, Susanna Falorni, Silvia Favilli, Ugo Limbruno
BACKGROUND: The epidemiological data on the incidence of congenital heart defects derive from retrospective registries based on birth discharge codes with methodological limits and different selection criteria. Our aim was to determine the actual incidence of congenital heart defects in the first year of life in a population of residents in a province of Tuscany, Italy. METHODS: This prospective study was conducted in 31 185 newborn residents in the province, enrolling a consecutive population throughout the first year of life and followed up at least for one year...
June 2018: Giornale Italiano di Cardiologia
Ibrahim Aliyu, Zainab Fumilayo Ibrahim
Cor-triatriatum is uncommon and cor-triatriatum dexter is rarer, and patients may remain asymptomatic in isolated cases especially if the partitioning is mild and nonobstructing. There may be other cardiac defects associated with it which are mostly right-sided cardiac defects such as atrial septal defect, Ebstein anomaly, and pulmonary stenosis. However, left-sided heart anomaly such as aortic regurgitation has been associated with it, but its association with transposition of the great vessels has not been documented before now...
April 2018: Journal of Cardiovascular Echography
Sami Nimer Ghazal
Severe chronic mitral regurgitation (MR) is known to cause left ventricular volume overload and subsequently left ventricular dilatation. Here, we present a case of a 68-year-old man with severe chronic MR which happened to coexist with atrial septal defect of secundum type leading to the right ventricular dilatation.
April 2018: Journal of Cardiovascular Echography
Heng Liu, Yin Hu, Bin Zhuang, Jing Yin, Xiao-Hui Chen, Juan Wang, Meng-Meng Li, Jing Xu, Xing-Yun Wang, Zhang-Bin Yu, Shu-Ping Han
Objectives: To explore and validate the differential expression of circRNAs in the myocardium of congenital ventricular septal defect (VSD) and to explore a new avenue of research regarding the pathological mechanisms of VSD. Methods: We detected circRNAs expression profiles in heart tissues taken from six aborted fetuses with VSD and normal group using circRNA microarray. Some differentially expressed circRNAs were studied by bioinformatics analysis. Finally, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm these results...
2018: International Journal of Medical Sciences
Paolo Ciancarella, Fabio Fazzari, Valentina Montano, Marco Guglielmo, Gianluca Pontone
A 21 year old male with no relevant medical history presented to our Institution for further assessments of a right paracardiac mass founded on a chest X-ray. Chest computed tomography revealed a wide median defect of the diaphragm at the level of xiphoid process of the sternum, with the herniation of omental fat tissue in the mediastinum. Cardiac magnetic resonance confirmed the presence of a huge hernia originating from the foramen of Morgagni (sterno-costal hiatus), displacing the heart leftwards and posteriorly and compressing the right ventricle (RV), giving to it a tubular shape...
April 2018: Journal of the Saudi Heart Association
Roxanne D Zwijnenburg, Vivan J M Baggen, Laurie W Geenen, Kelly R Voigt, Jolien W Roos-Hesselink, Annemien E van den Bosch
BACKGROUND: The development or persistence of pulmonary arterial hypertension (PAH) after atrial septal defect (ASD) closure at adult age is associated with a poor prognosis. The objective of this review was to investigate the prevalence of PAH before and after ASD closure and to identify factors that are associated with PAH. METHODS: EMBASE and MEDLINE databases were searched for publications until March 2017. All studies reporting the prevalence of PAH or data on pulmonary artery pressures both before and after surgical or percutaneous ASD closure in an adult population (≥16 years of age) were included...
July 2018: American Heart Journal
Peter B Manning
No abstract text is available yet for this article.
June 13, 2018: Annals of Thoracic Surgery
Martina Nassif, Frank van der Kley, Mohammad Abdelghani, Deborah N Kalkman, Rianne H A C M de Bruin-Bon, Berto J Bouma, Martin J Schalij, David R Koolbergen, Jan G P Tijssen, Barbara J M Mulder, Robbert J de Winter
Aims: Functional tricuspid regurgitation (TR) associated with atrial septal defects (ASDs) is frequently present due to right-sided volume-overload. Tricuspid valve (TV) repair is often considered in candidates for surgical ASD closure, and percutaneous TV repair is currently under clinical investigation. In this study, we develop a prediction model to identify patients with residual moderate/severe TR after percutaneous ASD closure. Methods and results: In this observational study, 172 adult patients (26% male, age 49 ± 17 years) with successful percutaneous ASD closure had pre- and post-procedural echocardiography...
June 13, 2018: European Heart Journal Cardiovascular Imaging
Ting Chen, Li Qiu, Lin Zhong, Qingfen Tao, Hanmin Liu, Lina Chen
There is a lack of data describing the role of flexible bronchoscopy (FB) in evaluating pulmonary diseases in children with congenital cardiovascular abnormalities in China. Determining whether those children suffer from respiratory complications may be useful for future preoperative planning and family counseling. The present study aimed to investigate the features and FB-associated findings with respect to pulmonary diseases in children with congenital cardiovascular abnormalities. The role of FB in guiding the treatment and safety of procedures was also evaluated...
June 2018: Experimental and Therapeutic Medicine
Preeti Jain, Basanti Malakar, Mehak Zahoor Khan, Savita Lochab, Archana Singh, Vinay K Nandicoori
Identifying and characterizing the individual contributors to bacterial cellular elongation and division will improve our understanding of their impact on cell growth and division. Here, we delineated the role of ftsQ, a terminal gene of the highly conserved division cell wall (dcw) operon, in growth, survival, and cell length maintenance in the human pathogen Mycobacterium tuberculosis (Mtb). We found that FtsQ overexpression significantly increases the cell length and number of multiseptate cells. FtsQ depletion in Mtb resulted in cells that were shorter than WT cells during the initial growth stages (4 days after FtsQ depletion), but were longer than WT cells at later stages (10 days after FtsQ depletion), and compromised the survival in vitro and in differentiated THP1 macrophages...
June 14, 2018: Journal of Biological Chemistry
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