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https://www.readbyqxmd.com/read/29666453/epidemiology-and-survival-outcomes-of-mucinous-adenocarcinomas-a-seer-population-based-study
#1
Guang-Dong Xie, Yi-Rong Liu, Yi-Zhou Jiang, Zhi-Ming Shao
To investigate the epidemiology, demographics and survival of mucinous adenocarcinomas (MACs), we identified 80,758 MAC patients in the Surveillance, Epidemiology and End Results (SEER) database. The reported incidence of MACs ebbed and flowed over time; however, a significant increase in reported annual age-adjusted incidences of MACs in the appendix, lung and bronchus was observed from 1981 to 2014. The demographics and outcomes of MACs differed by anatomic sites. MACs of the stomach had the largest percentage of poorly differentiated or undifferentiated tumors (41...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664358/tailored-management-of-stage-iiia-non-small-cell-lung-cancer-in-the-era-of-the-8th-edition-of-the-tnm-classification-for-lung-cancer
#2
Michael R Mueller
Stage IIIA is a very heterogeneous group encompassing locally advanced disease with T3 and T4 tumors without any nodal involvement and very small T1a primary tumors with unilateral mediastinal lymphatic disease. Tailored management defines interdisciplinary management requiring board decisions, which can sometimes be difficult particularly in stage IIIa non-small-cell lung cancer (NSCLC). Lobectomy still is standard of care even for stage I NSCLC, which increasingly is implemented using minimally invasive surgical technique...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29607193/two-cases-of-combined-thoracoscopy-and-open-chest-surgery-for-locally-advanced-lung-carcinoma
#3
Hitoshi Dejima, Hiroaki Kuroda, Katsutoshi Seto, Shozo Sakata, Takaaki Arimura, Tetsuya Mizuno, Noriaki Sakakura, Yukinori Sakao
Thoracoscopic surgery is becoming more widely used in thoracic surgery and has an increasingly important role to play. However, its use for locally advanced carcinoma (clinical stage T3-4) remains controversial. We adapted our procedure by combining thoracoscopy and open chest surgery (combination surgery) with the aim of reducing invasiveness while ensuring that the operation is safe and curative. Here we describe our experience. Case 1 was a man in his 60s who underwent induction chemoradiotherapy (cisplatin plus vinorelbine plus 40 Gy radiotherapy) followed by radical surgery for a left apical lung carcinoma with chest wall invasion...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29582686/the-effects-of-radiotherapy-on-the-survival-of-patients-with-unresectable-non-small-cell-lung-cancer
#4
Paolo Tini, Valerio Nardone, Pierpaolo Pastina, Luigi Pirtoli, Pierpaolo Correale, Antonio Giordano
Lung cancer represents the leading cause of cancer mortality across the worlds. At present, less than 30% of the patients can undergo curative surgery, while the majority of them (65%) are diagnosed with metastatic disease and directed to systemic treatments whose effects on the outcome of these patients depends by their performance status, disease-stage, histology, targetable-driving-mutation, and susceptibility to immunotherapy. In this context there is a subset of patients (25%) with locally advanced stage disease whose outcome might be greatly improved by using combined strategies of treatment including chemotherapy, radiotherapy and surgery...
March 27, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29572177/metastatic-spine-tumor-epidemiology-comparison-of-trends-in-surgery-across-two-decades-and-three-continents
#5
Ernest Wright, Federico Ricciardi, Mark Arts, Jacob M Buchowski, Chun Kee Chung, Maarten Coppes, Alan Crockard, Bart Depreitere, Michael Fehlings, Norio Kawahara, Chong Suh Lee, Yee Leung, Antonio Martin-Benlloch, Eric Massicotte, Christian Mazel, Cumhur Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Christian Ulbricht, Jorrit-Jan Verlaan, Mike Wang, David Choi
BACKGROUND: Indications for surgery for symptomatic spinal metastases have been better defined in recent years, and suitable outcome measures established, against a changing back-drop of patient characteristics, tumor behavior and oncological treatments. However variations still exist in the local management of patients with spinal metastases. The objective was to review global trends and habits in the surgical treatment of symptomatic spinal metastases, and how this has changed over the last 25 years...
March 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29568842/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-gastrointestinal-cancers-fad-or-standard-of-care
#6
Melissa Ching Ching Teo, Grace Hwei Ching Tan
Peritoneal metastases (PM) are the common endpoint for patients with advanced gastrointestinal cancers. PM from these cancers are often managed in a similar fashion to other sites of systemic metastases, but the following must be taken into consideration. (a) PM do not respond to systemic chemotherapy in the same fashion as liver and lung metastases. (b) PM cause local problems, resulting in disruption of chemotherapy. (c) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) actually work for PM...
March 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29559292/implications-of-pathologic-complete-response-beyond-mediastinal-nodal-clearance-with-high-dose-neoadjuvant-chemoradiation-therapy-in-locally-advanced-non-small-cell-lung-cancer
#7
Melissa A L Vyfhuis, Whitney M Burrows, Neha Bhooshan, Mohan Suntharalingam, James M Donahue, Josephine Feliciano, Shahed Badiyan, Elizabeth M Nichols, Martin J Edelman, Shamus R Carr, Joseph Friedberg, Gavin Henry, Shelby Stewart, Ashutosh Sachdeva, Edward M Pickering, Charles B Simone, Steven J Feigenberg, Pranshu Mohindra
PURPOSE: To determine, in a retrospective analysis of a large cohort of stage III non-small cell lung cancer patients treated with curative intent at our institution, whether having a pathologic complete response (pCR) influenced overall survival (OS) or freedom from recurrence (FFR) in patients who underwent definitive (≥60 Gy) neoadjuvant doses of chemoradiation (CRT). METHODS AND MATERIALS: At our institution, 355 patients with locally advanced non-small cell lung cancer were treated with curative intent with definitive CRT (January 2000-December 2013), of whom 111 underwent mediastinal reassessment for possible surgical resection...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29531807/nf-%C3%AE%C2%BAb-inhibition-by-dimethylaminoparthenolide-radiosensitizes-non-small-cell-lung-carcinoma-by-blocking-dna-double-strand-break-repair
#8
Peter V Deraska, Colin O'Leary, Hunter D Reavis, Shelby Labe, Tru-Khang Dinh, Jean-Bernard Lazaro, Christopher Sweeney, Alan D D'Andrea, David Kozono
Despite optimal chemotherapy, radiotherapy (RT), and/or surgery, non-small-cell lung carcinoma (NSCLC) remains the leading cause of cancer-related death in the US and worldwide. Thoracic RT, a mainstay in the treatment of locally advanced NSCLC, is often restricted in efficacy by a therapeutic index limited by sensitivity of tissues surrounding the malignancy. Therefore, radiosensitizers that can improve the therapeutic index are a vital unmet need. Inhibition of the NF-κB pathway is a proposed mechanism of radiosensitization...
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29502515/radiation-induced-chondrosarcoma-of-the-scapula-after-radiotherapy-for-lung-cancer-a-case-report-and-review-of-the-literature
#9
Abdelfettah Zidane, Adil Arsalane, Mohammed Lahkim, Issam Lalya, Abderrahim Ktaibi, Ismail Essadi
BACKGROUND: Radiotherapy associated with chemotherapy is a well-established treatment modality for locally advanced non-small cell lung cancers. Radiation-induced second malignancies, particularly radiation-induced sarcomas, are rare. Some authors reported a recent increase in the incidence of this rare complication, especially because of the improved prognosis and survival of patients after radiotherapy. Pathogenic mechanisms of radiation-induced sarcomas are poorly understood. However, diagnosis criteria are well established...
March 5, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29445602/uniportal-video-assisted-thoracoscopic-surgery-vats-sleeve-resections-for-non-small-cell-lung-cancer-patients-an-observational-prospective-study-and-technique-analysis
#10
Aris Koryllos, Erich Stoelben
Bronchus sleeve resection for operative treatment of non-small cell lung cancer (NSCLC) is a gold standard in modern thoracic surgery in cases of centrally located tumors or hilär lymph node metastases. Advanced instruments and growing surgical experience allowed surgeons to reduce the required incisions (from 3-port to uniportal) and to resect larger and more centrally located malignancies minimal invasively. It is a logical and expected advance in thoracic surgery that video-assisted thoracoscopic surgery (VATS) would be ultimately used also for complex bronchial resections...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29435285/significance-of-lung-biopsy-for-the-definitive-diagnosis-of-lung-nodules-in-breast-cancer-patients
#11
Kazuo Matsuura, Toshiyuki Itamoto, Midori Noma, Masahiro Ohara, Etsushi Akimoto, Mihoko Doi, Takashi Nishisaka, Koji Arihiro, Takayuki Kadoya, Morihito Okada
The aim of the present study was to evaluate the significance of lung biopsy for the modification of the treatment strategy in breast cancer patients who develop lung nodules during follow-up after breast surgery. Of 53 consecutive patients who underwent lung biopsies in two institutions (Hiroshima University Hospital and Hiroshima Prefectural Hospital, Hiroshima, Japan) between 1997 and 2014, 45 underwent lung surgery and 8 underwent percutaneous or transbronchial tumor biopsy for lung nodules developing after curative surgery for breast cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29425685/out-of-the-darkness-and-into-the-light-new-strategies-for-improving-treatments-for-locally-advanced-non-small-cell-lung-cancer
#12
Yun Zhang, Qin Lin, Ting Xu, Weiye Deng, Jinming Yu, Zhongxing Liao, Jinbo Yue
The standard treatment for locally advanced non-small cell lung cancer (LA NSCLC) includes surgery, radiotherapy, chemotherapy, or some combination of these modalities. Many clinical trials have been conducted in attempts to intensify treatment for LA NSCLC, but with little improvement. A therapeutic plateau had been reached, with no major progress in extending survival for patients with this disease. However, several recent trials of newer targeted therapies and immunotherapies may shed new light on potential therapeutic breakthroughs...
February 6, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29410947/before-or-after-evolving-neoadjuvant-approaches-to-locally-advanced-non-small-cell-lung-cancer
#13
REVIEW
Jennifer Lewis, Erin A Gillaspie, Evan C Osmundson, Leora Horn
The treatment of patients with stage IIIA ( N 2) non-small cell lung cancer (NSCLC) is one of the most challenging and controversial areas of thoracic oncology. This heterogeneous group is characterized by varying tumor size and location, the potential for involvement of surrounding structures, and ipsilateral mediastinal lymph node spread. Neoadjuvant chemotherapy, administered prior to definitive local therapy, has been found to improve survival in patients with stage IIIA ( N 2) NSCLC. Concurrent chemoradiation has also been evaluated in phase III studies in efforts to improve control of locoregional disease...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29409038/second-primary-cancer-in-survivors-of-locally-advanced-non-small-cell-lung-cancer-treated-with-concurrent-chemoradiation-followed-by-surgery
#14
Go Makimoto, Toshio Kubo, Isao Oze, Kadoaki Ohashi, Katsuyuki Hotta, Masahiro Tabata, Junichi Soh, Shinichi Toyooka, Kuniaki Katsui, Nagio Takigawa, Mitsune Tanimoto, Katsuyuki Kiura
The standard treatment for patients with locally advanced non-small-cell lung cancer (LA-NSCLC) is chemoradiotherapy (CRT), but surgical resection following induction CRT can extend overall survival in a select population. However, patients who survive longer are at risk of developing a second primary cancer (SPC). This is the first report to determine the incidence of SPC in survivors with LA-NSCLC after trimodal therapy. Between October 1997 and October 2013, 112 Stage III NSCLC patients underwent trimodal therapy in our hospital...
February 2, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29392577/post-obstructive-pneumonia-in-patients-with-cancer-a-review
#15
REVIEW
Kenneth V I Rolston, Lior Nesher
Published literature on post-obstructive pneumonia is difficult to find and consists mainly of case reports or small case series. This entity is encountered most often in patients with advanced lung malignancy but is also occasionally seen in patients with community-acquired pneumonia (CAP). There are substantial differences in the manifestations, treatment, and outcomes of post-obstructive pneumonia in these two settings. When obstruction is present in patients with CAP, it is almost always secondary to an underlying pulmonary malignancy...
February 1, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29389929/disease-recurrence-following-surgery-for-colorectal-cancer-five-year-follow-up
#16
Ashok Gunawardene, Brendan Desmond, Ali Shekouh, Peter Larsen, Elizabeth Dennett
AIM: To describe the patterns of recurrence in a contemporaneous cohort of patients undergoing surgery with curative intent for colorectal adenocarcinoma at a New Zealand hospital with five-year follow-up. METHODS: Patients with colorectal cancer undergoing potentially curative surgery between January 2010 and December 2012 were followed up for a median of 61 months with three-monthly CEA (carcinoembryonic antigen), a colonoscopy after one year and yearly computed tomography scans of the chest, abdomen and pelvis for the first three years...
February 2, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29387253/primary-pulmonary-lymphoepithelioma-like-carcinoma-in-singapore
#17
Chee Kiang Tay, Yang Chong Chua, Angela Takano, Madeline Yen Min Chee, Wan-Teck Lim, Cindy Lim, Mariko Siyue Koh
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of nonsmall cell lung cancer (NSCLC) predominantly reported in East Asia. We aimed to evaluate clinical characteristics, diagnosis, treatment, and prognosis of PPLELC in Singapore. METHODS: Retrospective review of all patients diagnosed with PPLELC at our center between 2000 and 2014. RESULTS: All 28 patients were Chinese, 67.9% were female, and the median age was 58 years (range37-76 years)...
January 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29357969/-surgical-procedures-and-perioperative-management-for-non-small-cell-lung-cancer-complicated-with-left-atrial-tumor-thrombus
#18
Tong Bao, Fei Xiao, Deruo Liu, Yongqing Guo, Chaoyang Liang
BACKGROUND: Non-small cell lung cancer with left atrial tumor thrombus accounts for a small proportion of local advanced lung cancer. Whether surgery could bring benefits, as well as surgical options are still controversial, and have always been hot spots in surgical research. We report a single center experience of surgical treatment to non-small cell lung cancer with left atrial tumor thrombus, aim to figure out more reasonable treatment strategy. METHODS: From August 2006 to July 2017, a total of 11 cases of non-small cell lung cancer with left atrial tumor thrombus underwent surgery in Thoracic Surgery Department of China-Japan Friendship Hospital...
January 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29313973/mouse-model-of-postsurgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#19
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of postsurgical high-risk features, that is, positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative preclinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29290266/long-term-outcomes-of-surgical-resection-for-stage-iv-non-small-cell-lung-cancer-a-national-analysis
#20
Chi-Fu Jeffrey Yang, Lin Gu, Shivani A Shah, Babatunde A Yerokun, Thomas A D'Amico, Matthew G Hartwig, Mark F Berry
OBJECTIVE: Treatment guidelines recommend surgical resection in select cases of stage IV non-small-cell lung cancer (NSCLC) but are based on limited evidence. This study evaluated outcomes associated with surgery in stage IV disease. METHODS: Factors associated with survival of stage IV NSCLC patients treated with surgery in the National Cancer Date Base (2004-2013) were evaluated using multivariable Cox proportional hazards analyses. Outcomes of the subset of patients with cT1-2, N0-1, M1 and cT3, N0, M1 disease treated with surgery or chemoradiation were evaluated using Kaplan-Meier analyses...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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