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https://www.readbyqxmd.com/read/28723810/let-s-get-real-about-health-care-reform
#1
Michael Karpf
In light of the ongoing debate about health care policy in the United States, including efforts to repeal and replace the Affordable Care Act, it will be critically important for the academic community to engage in the dialogue. Developing a viable approach to health care reform requires an understanding of the interaction and interdependence between choice, cost, and coverage in a competitive and functional market-based system. Some institutions have implemented models that indicate the feasibility of providing high-quality, efficient patient care while working within fixed budgets...
July 18, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28723615/nanoformulations-of-curcumin-an-emerging-paradigm-for-improved-remedial-application
#2
REVIEW
Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon, Dong Kee Jeong
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723417/long-term-morphine-delivery-via-slow-release-morphine-pellets-or-osmotic-pumps-plasma-concentration-analgesia-and-naloxone-precipitated-withdrawal
#3
Virginia D McLane, Ivy Bergquist, James Cormier, Deborah J Barlow, Karen L Houseknecht, Edward J Bilsky, Ling Cao
AIMS: Slow-release morphine sulfate pellets and osmotic pumps are common routes of chronic morphine delivery in mouse models, but direct comparisons of these drug delivery systems are lacking. In this study, we assessed the efficacy of slow-release pellets versus osmotic pumps in delivering morphine to adult mice. MAIN METHODS: Male C57BL/6NCr mice (8weeksold) were implanted subcutaneously with slow-release pellets (25mg morphine sulfate) or osmotic pumps (64mg/mL, 1...
July 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/28723407/nano-lipid-drug-conjugate-an-integrated-review
#4
REVIEW
Piya Adhikari, Paulami Pal, Anup Kr Das, Subhabrata Ray, Arpita Bhattacharjee, Bhaskar Mazumder
Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug, have the therapeutic actives chemically bound to a lipid moiety like fatty acids or phospholipids. Fabricated in nano-size, lipid-drug conjugate forms another breed of lipid nanoparticles. LDCs are prepared in order to increase the drug loading and hence prevent leakage of a highly polar drug from a lipophilic matrix. In turn, it assists to achieve active targeting of therapeutics with reduced side effect by altering the pharmacokinetic profile of the drug...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28722562/centers-of-excellence-in-healthcare-institutions-what-they-are-and-how-to-assemble-them
#5
James K Elrod, John L Fortenberry
BACKGROUND: Centers of excellence-specialized programs within healthcare institutions which supply exceptionally high concentrations of expertise and related resources centered on particular medical areas and delivered in a comprehensive, interdisciplinary fashion-afford many advantages for healthcare providers and the populations they serve. To achieve full value from centers of excellence, proper assembly is an absolute necessity, but guidance is somewhat limited. This effectively forces healthcare providers to pursue establishment largely via trial-and-error, diminishing opportunities for success...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28722560/peering-beyond-the-walls-of-healthcare-institutions-a-catalyst-for-innovation
#6
James K Elrod, John L Fortenberry
BACKGROUND: Healthcare providers operate in a unique industry characterized by pursuit of perhaps the most noble of missions: the delivery of vital health and medical services to those in need. Distinguishing features abound, differentiating the healthcare industry from others, with such facets having the potential to compel those serving in health and medical establishments to focus exclusively on their selected industry. But directing attention solely within can result in missed opportunities, especially regarding innovation...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28722556/spanning-maternal-newborn-and-child-health-mnch-and-health-systems-research-boundaries-conducive-and-limiting-health-systems-factors-to-improving-mnch-outcomes-in-west-africa
#7
Irene Akua Agyepong, Aku Kwamie, Edith Frimpong, Selina Defor, Abdallah Ibrahim, Genevieve C Aryeetey, Virgil Lokossou, Issiaka Sombie
BACKGROUND: Despite improvements over time, West Africa lags behind global as well as sub-Saharan averages in its maternal, newborn and child health (MNCH) outcomes. This is despite the availability of an increasing body of knowledge on interventions that improve such outcomes. Beyond our knowledge of what interventions work, insights are needed on others factors that facilitate or inhibit MNCH outcome improvement. This study aimed to explore health system factors conducive or limiting to MNCH policy and programme implementation and outcomes in West Africa, and how and why they work in context...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28722550/the-hub-and-spoke-organization-design-an-avenue-for-serving-patients-well
#8
James K Elrod, John L Fortenberry
BACKGROUND: The healthcare industry is characterized by intensive, never-ending change occurring on a multitude of fronts. Success in such tumultuous environments requires healthcare providers to be proficient in myriad areas, including the manner in which they organize and deliver services. Less efficient designs drain precious resources and hamper efforts to deliver the best care possible to patients, making it imperative that optimal pathways are identified and pursued. One particular avenue that offers great potential for serving patients efficiently and effectively is known as the hub-and-spoke organization design...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28722549/adaptive-reuse-in-the-healthcare-industry-repurposing-abandoned-buildings-to-serve-medical-missions
#9
James K Elrod, John L Fortenberry
BACKGROUND: Adaptive reuse-the practice of identifying, acquiring, renovating, and placing back into service a building or similar structure for a purpose different than that for which it was originally designed-offers great potential for addressing the spatial expansion needs of healthcare establishments in a unique and mutually beneficial manner. This repurposing approach, however, has received very little attention in the health sciences literature, diminishing the opportunities of those serving in hospitals, medical clinics, and related care providing institutions to acquire an understanding of the practice...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28722543/comparison-of-ovalbumin-and-ovalbumin-epitope-peptide-for-transdermal-delivery-and-vaccination-mediated-by-the-photothermal-effect-of-gold-nanorods
#10
Aung Thu Haine, Yuji Miyamoto, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Takuro Niidome
Transdermal protein delivery is a powerful and attractive method for protein therapy and dermal vaccination compared with other administrations. However, this delivery method is restricted by the low permeability of the stratum corneum, a hydrophobic barrier that restricts the entry of hydrophilic molecules such as proteins. In this study, we developed an improved gel patch system carrying ovalbumin and ovalbumin epitope peptide, and then compared their permeability into the skin. First, the gel patch was placed on mouse skin to allow contact with the polymer coated gold nanorods and then irradiated by a continuous-wave laser...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#11
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28722310/capitalizing-on-scientific-advances-to-improve-access-to-and-quality-of-children-s-mental-health-care
#12
Ann F Garland, Florencia Lebensohn-Chialvo, Kristopher G Hall, Erika R N Cameron
The majority of mental health problems begin in childhood or adolescence. The potential benefits of early identification and treatment of such problems are well established, and models of effective mental health interventions for children have proliferated in recent decades. However, barriers in access to care and challenges in assuring delivery of high-quality care significantly limit the public health impact of services for children and families. Specifically, the majority of children who need mental health care do not receive it, and when children are in care, many do not receive interventions that are most likely to have the greatest positive impact...
July 19, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28722258/in-vitro-evaluation-of-chitosan-coated-liposome-containing-both-coenzyme-q10-and-alpha-lipoic-acid-cytotoxicity-antioxidant-activity-and-antimicrobial-activity
#13
Guodong Zhao, Caibiao Hu, Ying Xue
BACKGROUND: Chitosan-coated liposome containing both coenzyme Q10 and alpha-lipoic acid (CCAL) was a novel multifunctional nano delivery system exhibited long-term stability at room temperature and high encapsulation efficiency. Which containing two kinds of antioxidants (coenzyme Q10 and alpha-lipoic acid) and two antibacterial agents (chitosan and alpha-lipoic acid). However, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of CCAL, has not been systematically evaluated...
July 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28722250/residential-age-care-and-domiciliary-oral-health-services-reach-oht-the-development-of-a-metropolitan-oral-health-programme-in-sydney-australia
#14
F A Clive Wright, Garry Law, Steven K-Y Chu, John S Cullen, David G Le Couteur
OBJECTIVE: To describe an oral health care programme for older people in Residential Aged Care Facilities (RACFs) to improve access to care and support facilities. INTRODUCTION: Different models of residential care have been proposed, but few have been comprehensive (providing on-site health promotion and service delivery) or sustainable. METHODS: A partnership model of oral health care, with dental services plus oral health education, was integrated into the community outreach services of a metropolitan hospital department of aged care...
July 19, 2017: Gerodontology
https://www.readbyqxmd.com/read/28722238/the-preparation-of-microfluidic-architecture-with-monolithic-materials-using-a-dual-porous-silica-structure
#15
Christopher Birch, Mohammad Mehdi Nasr Esfahani, Kirsty J Shaw, Cordula Kemp, Stephen James Haswell, Charlotte Dyer
A microfluidic device (MD) has been developed which features a porous silica (PS) monolithic disk synthesized from tetramethyl orthosilicate (TMOS), incorporated into the device post-fabrication and sealed in place with a second PS monolithic layer, synthesized from potassium silicate. This dual porous silica (DPS) structure provides a pathway for sample introduction to the microfluidic device and offers an ideal platform for solid phase extraction (SPE) methodologies which can be rapidly and efficiently integrated into a chip-based format...
July 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28722140/erythrocyte-membrane-enveloped-perfluorocarbon-as-nanoscale-artificial-red-blood-cells-to-relieve-tumor-hypoxia-and-enhance-cancer-radiotherapy
#16
Min Gao, Chao Liang, Xuejiao Song, Qian Chen, Qiutong Jin, Chao Wang, Zhuang Liu
Hypoxia, a common feature within many types of solid tumors, is known to be closely associated with limited efficacy for cancer therapies, including radiotherapy (RT) in which oxygen is essential to promote radiation-induced cell damage. Here, an artificial nanoscale red-blood-cell system is designed by encapsulating perfluorocarbon (PFC), a commonly used artificial blood substitute, within biocompatible poly(d,l-lactide-co-glycolide) (PLGA), obtaining PFC@PLGA nanoparticles, which are further coated with a red-blood-cell membrane (RBCM)...
July 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28722121/the-importance-of-species-identity-and-interactions-on-multifunctionality-depends-on-how-ecosystem-functions-are-valued
#17
Eleanor M Slade, Laura Kirwan, Thomas Bell, Christopher Philipson, Owen T Lewis, Tomas Roslin
Studies investigating how biodiversity affects ecosystem functioning increasingly focus on multiple functions measured simultaneously ('multifunctionality'). However, few such studies assess the role of species interactions, particularly under alternative environmental scenarios, despite interactions being key to ecosystem functioning. Here we address five questions of central importance to ecosystem multifunctionality using a terrestrial animal system: 1) Does the contribution of individual species differ for different ecosystem functions?; 2) Do inter-species interactions affect the delivery of single functions and multiple functions?; 3) Does the community composition which maximises individual functions also maximise multifunctionality?; 4) Is the functional role of individual species, and the effect of interspecific interactions, modified by changing environmental conditions?; and 5) How do these roles and interactions change under varying scenarios where ecosystem services are weighted to reflect different societal preferences? We manipulated species' relative abundance in dung beetle communities and measured 16 functions contributing to dung decomposition, plant productivity, nutrient recycling, reduction of greenhouse gases, and microbial activity...
July 19, 2017: Ecology
https://www.readbyqxmd.com/read/28722090/-evaluation-of-a-new-closure-technique-of-large-defects-after-endoscopic-full-thickness-resection
#18
Xiao Liu, Lizhou Dou, Yong Liu, Shun He, Yueming Zhang, Xinying Yu, Yan Ke, Xudong Liu, Ruigang Wang, Guiqi Wang
OBJECTIVE: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy. METHODS: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28721904/treatment-planning-system-calculation-errors-are-present-in-most-imaging-and-radiation-oncology-core-houston-phantom-failures
#19
James R Kerns, Francesco Stingo, David S Followill, Rebecca M Howell, Adam Melancon, Stephen F Kry
PURPOSE: The anthropomorphic phantom program at the Houston branch of the Imaging and Radiation Oncology Core (IROC-Houston) is an end-to-end test that can be used to determine whether an institution can accurately model, calculate, and deliver an intensity modulated radiation therapy dose distribution. Currently, institutions that do not meet IROC-Houston's criteria have no specific information with which to identify and correct problems. In the present study, an independent recalculation system was developed to identify treatment planning system (TPS) calculation errors...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721831/transient-production-of-recombinant-pharmaceutical-proteins-in-plants-evolution-and-perspectives
#20
Lilya Kopertekh, Joachim Schiemann
During the last two decades the production of pharmaceutical proteins in plants evolved from proof of concept to established technology adopted by several biotechnological companies. This progress is particularly based on intensive research starting stable genetic transformation and moving to transient expression. Due to its advantages in yield and speed of protein production transient expression platforms became leading plant-based manufacturing technology. Current transient expression methods rely on Agrobacterium-mediated delivery of expression vectors into plant cells...
July 18, 2017: Current Medicinal Chemistry
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