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Diffusion of innovation

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https://www.readbyqxmd.com/read/27925028/errata-factors-associated-with-the-diffusion-rate-of-innovations-a-pilot-study-from-the-perspective-of-the-brazilian-unified-national-health-system
#1
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[This corrects the article doi: 10.1590/0102-311X00067516].
December 1, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27907196/the-potential-for-conservation-tillage-adoption-in-the-san-joaquin-valley-california-a-qualitative-study-of-farmer-perspectives-and-opportunities-for-extension
#2
Anne V Bossange, Kandace M Knudson, Anil Shrestha, Ronald Harben, Jeffrey P Mitchell
Conservation tillage (CT) systems have a number of potential benefits including lower crop production costs and the ability to reduce soil erosion that have made them common in several regions of the world. Although CT systems have been researched and successfully implemented on some farms in California's San Joaquin Valley (SJV), overall adoption is low and the reasons for the region's comparatively low rates of adoption are not known. In 2011, we conducted written surveys and interviews with SJV farmers to identify characteristics of farmers who adopt or do not adopt CT, to determine reasons for non-adoption of CT, and to learn how successful CT adoption takes place in the SJV...
2016: PloS One
https://www.readbyqxmd.com/read/27895967/medical-representatives-intention-to-use-information-technology-in-pharmaceutical-marketing
#3
Eun-Seon Kwak, Hyejung Chang
OBJECTIVES: Electronic detailing (e-detailing), the use of electronic devices to facilitate sales presentations to physicians, has been adopted and expanded in the pharmaceutical industry. To maximize the potential outcome of e-detailing, it is important to understand medical representatives (MRs)' behavior and attitude to e-detailing. This study investigates how information technology devices such as laptop computers and tablet PCs are utilized in pharmaceutical marketing, and it analyzes the factors influencing MRs' intention to use devices...
October 2016: Healthcare Informatics Research
https://www.readbyqxmd.com/read/27895516/a-prospective-observational-study-comparing-the-pk-pd-relationships-of-generic-meropenem-mercide-%C3%A2-to-the-innovator-brand-in-critically-ill-patients
#4
Mervyn Mer, Jacques Rene Snyman, Constance Elizabeth Jansen van Rensburg, Jacob John van Tonder, Ilze Laurens
INTRODUCTION: Clinicians' skepticism, fueled by evidence of inferiority of some multisource generic antimicrobial products, results in the underutilization of more cost-effective generics, especially in critically ill patients. The aim of this observational study was to demonstrate equivalence between the generic or comparator brand of meropenem (Mercide(®)) and the leading innovator brand (Meronem(®)) by means of an ex vivo technique whereby antimicrobial activity is used to estimate plasma concentration of the active moiety...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27884973/the-emerging-role-of-immune-checkpoint-inhibition-in-malignant-lymphoma
#5
Ida Hude, Stephanie Sasse, Andreas Engert, Paul J Bröckelmann
To evade elimination by the host immune system, tumor cells commonly exploit physiological immune checkpoint pathways, restraining efficient anti-tumor immune cell function. Growing understanding of the complex dialog between tumor cells and their microenvironment contributed to the development of immune checkpoint inhibitors. This innovative strategy has demonstrated paradigm-shifting clinical activity in various malignancies. Antibodies targeting programmed death 1 and cytotoxic T-lymphocyte-associated protein-4 are also being investigated in lymphoid malignancies with varying levels of activity and a favorable toxicity profile...
November 24, 2016: Haematologica
https://www.readbyqxmd.com/read/27884730/a-qualitative-application-of-diffusion-of-innovations-to-adolescents-perceptions-of-long-acting-reversible-contraception-s-attributes
#6
Molly K Murphy, Pamela J Burke, Sadia Haider
BACKGROUND: Long-acting reversible contraceptive (LARC) methods are the most effective forms of reversible contraception but adolescents often opt for other, less effective methods. This study explored how adolescents viewed LARC as an innovation to be adopted or rejected, and how their assessment of innovation attributes impacted their decisions about LARC. MATERIALS AND METHODS: Sexually active adolescents between 15-22 years old (n=22) participated in semi-structured qualitative interviews...
November 21, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27880984/diffuse-large-b-cell-lymphoma-with-primary-treatment-failure-ultra-high-risk-features-and-benchmarking-for-experimental-therapies
#7
Luciano J Costa, Kami Maddocks, Narendranath Epperla, Nishitha M Reddy, Reem Karmali, Elvira Umyarova, Veronika Bachanova, Christiana Costa, Martha Glenn, Julio Chavez, Oscar Calzada, Frederick Lansigan, Hossain Nasheed, Stefan Barta, Zheng Zhou, Michael Jaglal, Saurabh Chhabra, Francisco Hernandez-Ilizaliturri, Ana C Xavier, Amitkumar Mehta, Deniz Peker, Andreas Forero-Torres, Zeina Al-Mansour, Andrew M Evens, Jonathon B Cohen, Christopher R Flowers, Timothy S Fenske, Mehdi Hamadani
While a subset of patients with DLBCL relapsing after upfront chemoimmunotherapy can be cured with salvage therapy and autologous hematopoietic cell transplantation (auto-HCT), the outcome of patients with primary treatment failure (PTF) is less clear. For this study we analyzed 331 patients from 15 US institutions with DLBCL and PTF, defined as primary progression while on upfront chemoimmunotherapy (PP), residual disease at the end of upfront therapy (RD) or relapse < 6 months from end of therapy (early relapse; ER)...
November 23, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27866793/tracking-the-dissemination-of-a-culturally-targeted-brochure-to-promote-awareness-of-hereditary-breast-and-ovarian-cancer-among-black-women
#8
Courtney Lynam Scherr, Linda Bomboka, Alison Nelson, Tuya Pal, Susan Thomas Vadaparampil
OBJECTIVE: Black women have a higher rate of BRCA1 and BRCA2 (BRCA) mutations, compared with other populations, that increases their risk for hereditary breast and ovarian cancer (HBOC). However, Black women are less likely to know about HBOC and genetic testing. Based on a request from a community advisory panel of breast cancer survivors, community leaders and healthcare providers in the Black community, our team developed a culturally targeted educational brochure to promote awareness of HBOC among Black women...
October 31, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27857013/-structural-model-of-evidence-based-practice-implementation-among-clinical-nurses
#9
Hyunyoung Park, Keum Seong Jang
PURPOSE: This study was conducted to develop and test a structural model of evidence-based practice (EBP) implementation among clinical nurses. The model was based on Melnyk and Fineout-Overholt's Advancing Research and Clinical Practice through Close Collaboration model and Rogers' Diffusion of Innovations theory. METHODS: Participants were 410 nurses recruited from ten different tertiary hospitals in Korea. A structured self-report questionnaire was used to assess EBP knowledge/skills, EBP beliefs, EBP attitudes, organizational culture & readiness for EBP, dimensions of a learning organization and organizational innovativeness...
October 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/27832116/real-time-social-data-collection-in-rural-bangladesh-via-a-microtasks-for-micropayments-platform-on-android-smartphones
#10
Andrew Reid Bell, Patrick S Ward, Mary E Killilea, Md Ehsanul Haque Tamal
The advent of cheap smartphones in rural areas across the globe presents an opportunity to change the mode with which researchers engage hard-to-reach populations. In particular, smartphones allow researchers to connect with respondents more frequently than standard household surveys, opening a new window into important short-term variability in key measures of household and community wellbeing. In this paper, we present early results from a pilot study in rural Bangladesh using a 'microtasks for micropayments' model to collect a range of community and household living standards data using Android smartphones...
2016: PloS One
https://www.readbyqxmd.com/read/27828021/design-fabrication-and-testing-of-a-shack-hartmann-sensor-with-an-automatic-registration-feature
#11
Wenchen Zhou, Thomas W Raasch, Allen Y Yi
In this research, design, construction, and testing of an innovative Shack-Hartmann sensor are described. As the most critical component, a polymer microlens array is injection molded and mounted on a board-level CMOS camera such that the focal plane of the microlens array is on the camera's image plane. To allow for automatic registration of the spots of the measured area, a diffusing surface was created at the center of the lens array in the same diamond machining process in an uninterrupted operation. This unique diffusing surface does not generate an image spot...
October 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27825383/dengue-research-networks-building-evidence-for-policy-and-planning-in-brazil
#12
Bruna de Paula Fonseca E Fonseca, Fabio Zicker
BACKGROUND: The analysis of scientific networks has been applied in health research to map and measure relationships between researchers and institutions, describing collaboration structures, individual roles, and research outputs, and helping the identification of knowledge gaps and cooperation opportunities. Driven by dengue continued expansion in Brazil, we explore the contribution, dynamics and consolidation of dengue scientific networks that could ultimately inform the prioritisation of research, financial investments and health policy...
November 8, 2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27816263/non-sink-dissolution-behavior-and-solubility-limit-of-commercial-tacrolimus-amorphous-formulations
#13
Niraj S Trasi, Hitesh S Purohit, Hong Wen, Dajun D Sun, Lynne S Taylor
An increasing number of drugs with low aqueous solubility are being formulated and marketed as amorphous solid dispersions because the amorphous form can generate a higher solubility compared to the crystalline solid. The amorphous solubility of a drug can be determined experimentally using various techniques. Most studies in this area investigate the drug in its pure form and do not evaluate any effects from other formulation ingredients. In this study, we use 6 marketed amorphous oral drug products, capsules containing 5 mg of tacrolimus, and various excipients, consisting of 1 innovator product and 5 generics...
November 2, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27816034/determinants-associated-with-e-cigarette-adoption-and-use-intention-among-college-students
#14
Hsiao-Yun Lee, Hsien-Chang Lin, Dong-Chul Seo, David K Lohrmann
OBJECTIVE: This study investigated characteristics of potential and current e-cigarette users based on four different levels of use acceptability along with the determinants that promote e-cigarette use acceptability among college students. METHODS: College students (N=1198) aged 18-25years at a Midwestern university were surveyed in September-October 2015. Participants were categorized into four groups based on e-cigarette use acceptability adapted from the Diffusion of Innovation Theory (i...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27812475/advances-in-perovskite-solar-cells
#15
Chuantian Zuo, Henk J Bolink, Hongwei Han, Jinsong Huang, David Cahen, Liming Ding
Organolead halide perovskite materials possess a combination of remarkable optoelectronic properties, such as steep optical absorption edge and high absorption coefficients, long charge carrier diffusion lengths and lifetimes. Taken together with the ability for low temperature preparation, also from solution, perovskite-based devices, especially photovoltaic (PV) cells have been studied intensively, with remarkable progress in performance, over the past few years. The combination of high efficiency, low cost and additional (non-PV) applications provides great potential for commercialization...
July 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27798636/consume-modify-share-cms-the-interplay-between-individual-decisions-and-structural-network-properties-in-the-diffusion-of-information
#16
Hila Koren, Ido Kaminer, Daphne Ruth Raban
Widely used information diffusion models such as Independent Cascade Model, Susceptible Infected Recovered (SIR) and others fail to acknowledge that information is constantly subject to modification. Some aspects of information diffusion are best explained by network structural characteristics while in some cases strong influence comes from individual decisions. We introduce reinvention, the ability to modify information, as an individual level decision that affects the diffusion process as a whole. Based on a combination of constructs from the Diffusion of Innovations and the Critical Mass Theories, the present study advances the CMS (consume, modify, share) model which accounts for the interplay between network structure and human behavior and interactions...
2016: PloS One
https://www.readbyqxmd.com/read/27777335/complexities-of-introducing-group-medical-visits-with-nurse-practitioners-in-british-columbia
#17
Laura Housden, Sabrina T Wong, Annette J Browne, Martin Dawes
In Canada, increasing numbers of people with chronic conditions have prompted calls for innovative approaches to delivering primary care. These approaches may include group medical visits (GMVs) and the introduction of nurse practitioners (NPs). We examined why NPs in the province of British Columbia were not using GMVs. This case study is part of a larger research project that examined the impact of GMVs with NPs for patients with chronic conditions. We completed open-ended interviews with seven NPs working in primary care...
October 24, 2016: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/27770869/a-new-bi-layered-scaffold-for-osteochondral-tissue-regeneration-in-vitro-and-in-vivo-preclinical-investigations
#18
M Sartori, S Pagani, A Ferrari, V Costa, V Carina, E Figallo, M C Maltarello, L Martini, M Fini, G Giavaresi
Current treatments for acute or degenerative chondral and osteochondral lesions are in need of improvement, as these types of injuries lead to disability and worsen the quality of life in a high percentage of patients. The aim of this study was to develop a new bi-layered scaffold for osteochondral tissue regeneration through a "biomimetic" and "bioinspired" approach. For chondral regeneration, the scaffold was realized with an organic compound (type I collagen), while for the regeneration of the subchondral layer, bioactive magnesium-doped hydroxyapatite (Mg/HA) crystals were co-precipitated with the organic component of the scaffold...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27769214/innovate-a-prospective-cohort-study-combining-serum-and-urinary-biomarkers-with-novel-diffusion-weighted-magnetic-resonance-imaging-for-the-prediction-and-characterization-of-prostate-cancer
#19
Edward Johnston, Hayley Pye, Elisenda Bonet-Carne, Eleftheria Panagiotaki, Dominic Patel, Myria Galazi, Susan Heavey, Lina Carmona, Alexander Freeman, Giorgia Trevisan, Clare Allen, Alexander Kirkham, Keith Burling, Nicola Stevens, David Hawkes, Mark Emberton, Caroline Moore, Hashim U Ahmed, David Atkinson, Manuel Rodriguez-Justo, Tony Ng, Daniel Alexander, Hayley Whitaker, Shonit Punwani
BACKGROUND: Whilst multi-parametric magnetic resonance imaging (mp-MRI) has been a significant advance in the diagnosis of prostate cancer, scanning all patients with elevated prostate specific antigen (PSA) levels is considered too costly for widespread National Health Service (NHS) use, as the predictive value of PSA levels for significant disease is poor. Despite the fact that novel blood and urine tests are available which may predict aggressive disease better than PSA, they are not routinely employed due to a lack of clinical validity studies...
October 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27759793/factors-associated-with-the-diffusion-rate-of-innovations-a-pilot-study-from-the-perspective-of-the-brazilian-unified-national-health-system
#20
Roberto Eduardo Schneiders, Ricardo de March Ronsoni, Flávia Mori Sarti, Marcelo Eidi Nita, Ediane de Assis Bastos, Ivan Ricardo Zimmermann, Fernando Fagundes Ferreira
Budget Impact Analyses require a set of essential information on health technology innovation, including expected rates of adoption. There is an absence of studies investigating trends, magnitude of budgetary effects and determinants of diffusion rates for health technology innovations worldwide during the last decades. The present study proposes a pilot assessment on main determinants influencing diffusion rates of pharmaceutical innovations within the Brazilian Unified National Health System (SUS). Data from the Brazilian Health Informatics Department (DATASUS) was gathered to establish the main determinants of diffusion rates of health technology innovations in Brazil, specifically referring to pharmaceutical innovations incorporated in the Brazilian Program for Specialized Pharmaceutical Services (CEAF) at SUS...
October 10, 2016: Cadernos de Saúde Pública
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