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Diffusion of innovation

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https://www.readbyqxmd.com/read/28927451/implementing-non-invasive-prenatal-testing-for-aneuploidy-in-a-national-healthcare-system-global-challenges-and-national-solutions
#1
Rachèl V van Schendel, Carla G van El, Eva Pajkrt, Lidewij Henneman, Martina C Cornel
BACKGROUND: Since the introduction of non-invasive prenatal testing (NIPT) in 2011, mainly by commercial companies, a growing demand for NIPT from the public and healthcare professionals has been putting pressure on the healthcare systems of various countries. This study identifies the challenges of establishing a responsible implementation of NIPT for aneuploidy in prenatal healthcare, by looking at the Netherlands. METHODS: A mixed methods approach involving 13 stakeholder interviews, document analysis and (participatory) observations of the Dutch NIPT Consortium meetings were used...
September 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28926278/planar-optical-nano-antennas-resolve-cholesterol-dependent-nanoscale-heterogeneities-in-the-plasma-membrane-of-living-cells
#2
Raju Regmi, Pamina Martina Winkler, Valentin Flauraud, Kyra Borgman, Carlo Manzo, Juergen Brugger, Herve Rigneault, Jerome Wenger, Maria F Garcia-Parajo
Optical nano-antennas can efficiently confine light into nanoscopic hotspots enabling single-molecule detection sensitivity at biological relevant conditions. This innovative approach to breach the diffraction limit offers a versatile platform to investigate the dynamics of individual biomolecules in living cell membranes and their partitioning into cholesterol-dependent lipid nanodomains. Here, we present optical nano-antenna arrays with accessible surface hotspots to study the characteristic diffusion dynamics of phosphoethanolamine (PE) and sphingomyelin (SM) in the plasma membrane of living cells at the nanoscale...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28925959/preventing-surgical-site-infections-using-a-natural-biodegradable-antibacterial-coating-on-surgical-sutures
#3
Jochen Reinbold, Ann-Kristin Uhde, Ingrid Müller, Tobias Weindl, Jürgen Geis-Gerstorfer, Christian Schlensak, Hans-Peter Wendel, Stefanie Krajewski
Surgical site infections (SSIs) are one of the most common nosocomial infections, which can result in serious complications after surgical interventions. Foreign materials such as implants or surgical sutures are optimal surfaces for the adherence of bacteria and subsequent colonization and biofilm formation. Due to a significant increase in antibiotic-resistant bacterial strains, naturally occurring agents exhibiting antibacterial properties have great potential in prophylactic therapies. The aim of this study was to develop a coating for surgical sutures consisting of the antibacterial substance totarol, a naturally occurring diterpenoid isolated from Podocarpustotara in combination with poly(lactide-co-glycolide acid) (PLGA) as a biodegradable drug delivery system...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28916114/-scleritis-and-episcleritis
#4
REVIEW
E Héron, T Bourcier
Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28900526/lung-us-features-of-severe-interstitial-pneumonia-case-report-and-review-of-the-literature
#5
Tiziano Perrone, Federica Quaglia
BACKGROUND: Chlamydia pneumonia is reported to account for a relatively large number of cases of CAP. In elderly patients in particular, the clinical presentation can be a severe form of diffuse interstitial pneumonia. The chest X-ray presentation is aspecific. Lung US can show a typical pattern of diffuse interstitial lung syndrome; in some cases, like the present one, the association of multiple B lines with a coarse and thickened pleural line points to a more likely diagnosis of interstitial pneumonia...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28898420/characterization-of-hyperbranched-core-multishell-nanocarriers-as-an-innovative-drug-delivery-system-for-the-application-at-the-oral-mucosa
#6
J Jager, K Obst, S B Lohan, J Viktorov, S Staufenbiel, H Renz, M Unbehauen, R Haag, S Hedtrich, C Teutloff, M C Meinke, K Danker, H Dommisch
BACKGROUND AND OBJECTIVES: In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approach. However, their efficacy is limited. Dilution effects due to saliva hinder the adherence and the penetration of drug formulations. Therefore, the bioavailability of oral topical drugs is insufficient, and patients may suffer from disease over years, if not life-long...
September 12, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28893242/how-is-success-achieved-by-individuals-innovating-for-patient-safety-and-quality-in-the-nhs
#7
Laura Sheard, Cath Jackson, Rebecca Lawton
BACKGROUND: Innovation in healthcare is said to be notoriously difficult to achieve and sustain yet simultaneously the health service is under intense pressure to innovate given the ever increasing demands placed upon it. Whilst many studies have looked at diffusion of innovation from an organisational perspective, few have sought to understand how individuals working in healthcare innovate successfully. We took a positive deviance approach to understand how innovations are achieved by individuals working in the NHS...
September 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28885536/moving-upstream-in-u-s-hospital-care-toward-investments-in-population-health
#8
James W Begun, Sandra Potthoff
The root causes for most health outcomes are often collectively referred to as the social determinants of health. Hospitals and health systems now must decide how much to "move upstream," or invest in programs that directly affect the social determinants of health. Moving upstream in healthcare delivery requires an acceptance of responsibility for the health of populations. We examine responses of 950 nonfederal, general hospitals in the United States to the 2015 American Hospital Association Population Health Survey to identify characteristics that distinguish those hospitals that are most aligned with population health and most engaged in addressing social determinants of health...
September 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28883511/cytotoxic-response-against-epstein-barr-virus-coexists-with-diffuse-large-b-cell-lymphoma-tolerogenic-microenvironment-clinical-features-and-survival-impact
#9
Melina Cohen, Aldana G Vistarop, Fuad Huaman, Marina Narbaitz, Fernanda Metrebian, Elena De Matteo, María V Preciado, Paola A Chabay
Epstein-Barr Virus (EBV) is present in neoplastic cells of 15% of Asian and Latin-American diffuse large B-cell lymphoma (DLBCL) patients. Even though a tolerogenic microenvironment was recently described in DLBCL, little is known concerning immunomodulatory features induced by EBV. As suggested in Hodgkin lymphoma, EBV-specific cytotoxic T-cells are increased but showing immune exhaustion features. Hence, host immunity suppression may play a critical role in tumor progression. This study aimed to investigate, whether an association between tumor microenvironment features and EBV presence is taking place, and its clinical correlate...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883176/implementing-a-data-management-platform-for-longitudinal-health-research
#10
Jan-Patrick Weiß, Ursula Hübner, Jens Rauch, Jens Hüsers, Frank Teuteberg, Moritz Esdar, Jan-David Liebe
Health IT adoption research is rooted in Rogers' Diffusion of Innovation theory, which is based on longitudinal analyses. However, many studies in this field use cross-sectional designs. The aim of this study therefore was to design and implement a system to (i) consolidate survey data sets originating from different years (ii) integrate additional secondary data and (iii) query and statistically analyse these longitudinal data. Our system design comprises a 5-tier-architecture that embraces tiers for data capture, data representation, logics, presentation and integration...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28866708/quantitative-visualization-of-dynamic-tracer-transportation-in-the-extracellular-space-of-deep-brain-regions-using-tracer-based-magnetic-resonance-imaging
#11
Jin Hou, Wei Wang, Xianyue Quan, Wen Liang, Zhiming Li, Deji Chen, Hongbin Han
BACKGROUND This study assessed an innovative tracer-based magnetic resonance imaging (MRI) system to visualize the dynamic transportation of tracers in regions of deep brain extracellular space (ECS) and to measure transportation ability and ECS structure. MATERIAL AND METHODS Gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) was the chosen tracer and was injected into the caudate nucleus and thalamus. Real-time dynamic transportation of Gd-DTPA in ECS was observed and the results were verified by laser scanning confocal microscopy...
September 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28860716/preliminary-study-of-nanonized-lamotrigine-containing-products-for-nasal-powder-formulation
#12
Péter Gieszinger, Ildikó Csóka, Edina Pallagi, Gábor Katona, Orsolya Jójárt-Laczkovich, Piroska Szabó-Révész, Rita Ambrus
The nasal delivery of drugs offers a great alternative route to avoid adverse events and to increase patient compliance due to its advantageous properties. Besides nasal application, topical, systemic and central effects are also available. Nasal powders (NPs) have better adhesion due to the additive polymers that may be, eg, gelling or good wettability agents; thus, their bioavailability is better compared to the liquid formulations. Using nanoparticles, innovative and more efficient products can be achieved, which may lead to the improvement of different therapies...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28859565/neuroplasticity-and-the-brain-connectome-what-can-jean-talairach-s-reflections-bring-to-modern-psychosurgery
#13
Pierre Bourdillon, Caroline Apra, Marc Lévêque, Fabien Vinckier
Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into practice. Currently, these concepts are being confirmed by modern techniques such as neuroimaging and computational neurosciences, and could pave the way for therapeutic innovation in psychiatry...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28858025/chief-pas-and-diffusion-of-pa-innovation
#14
Benjamin Olmedo
No abstract text is available yet for this article.
September 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28847092/development-of-a-novel-biochar-psf-mixed-matrix-membrane-and-study-of-key-parameters-in-treatment-of-copper-and-lead-contaminated-water
#15
Jinsong He, Yihua Song, J Paul Chen
Mixed matrix membrane (MMM) has attracted increasing attentions in various applications, such as water treatment. In this study, an innovative biochar/polysulfone (PSF) mixed matrix hollow fiber membrane was fabricated by incorporating micro-sized biochar particles in the PSF matrix. It was demonstrated that the membrane was more hydrophilic than the pure PSF membrane. Higher water flux was obtained. The adsorption of copper and lead on the MMM increased as the pH was increased with the maximum adsorption capacity observed at pH > 4...
November 2017: Chemosphere
https://www.readbyqxmd.com/read/28843639/characteristics-of-the-most-recently-awarded-magnetic-resonance-imaging-patents-in-the-united-states
#16
REVIEW
Sushma Gaddam, Gregory Lemberskiy, Andrew B Rosenkrantz
PURPOSE: To characterize recent magnetic resonance imaging (MRI) technical development and innovation based on data regarding MRI-related patents awarded in 2016. METHODS: The US Patent and Trademark Office website was searched for patents awarded in 2016 and an abstract containing "magnetic resonance." Patent characteristics were summarized. An MRI physicist classified patents' themes. RESULTS: A total of 423 MRI-related patents were awarded in 2016...
July 29, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28841648/network-analysis-of-surgical-innovation-measuring-value-and-the-virality-of-diffusion-in-robotic-surgery
#17
George Garas, Isabella Cingolani, Pietro Panzarasa, Ara Darzi, Thanos Athanasiou
BACKGROUND: Existing surgical innovation frameworks suffer from a unifying limitation, their qualitative nature. A rigorous approach to measuring surgical innovation is needed that extends beyond detecting simply publication, citation, and patent counts and instead uncovers an implementation-based value from the structure of the entire adoption cascades produced over time by diffusion processes. Based on the principles of evidence-based medicine and existing surgical regulatory frameworks, the surgical innovation funnel is described...
2017: PloS One
https://www.readbyqxmd.com/read/28836996/random-or-predictable-adoption-patterns-of-chronic-care-management-practices-in-physician-organizations
#18
Isomi M Miake-Lye, Emmeline Chuang, Hector P Rodriguez, Gerald F Kominski, Elizabeth M Yano, Stephen M Shortell
BACKGROUND: Theories, models, and frameworks used by implementation science, including Diffusion of Innovations, tend to focus on the adoption of one innovation, when often organizations may be facing multiple simultaneous adoption decisions. For instance, despite evidence that care management practices (CMPs) are helpful in managing chronic illness, there is still uneven adoption by physician organizations. This exploratory paper leverages this natural variation in uptake to describe inter-organizational patterns in adoption of CMPs and to better understand how adoption choices may be related to one another...
August 24, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28835273/meausures-of-organizational-characteristics-associated-with-adoption-and-or-implementation-of-innovations-a-systematic-review
#19
Jennifer D Allen, Samuel D Towne, Annette E Maxwell, Lisa DiMartino, Bryan Leyva, Deborah J Bowen, Laura Linnan, Bryan J Weiner
BACKGROUND: This paper identifies and describes measures of constructs relevant to the adoption or implementation of innovations (i.e., new policies, programs or practices) at the organizational-level. This work is intended to advance the field of dissemination and implementation research by aiding scientists in the identification of existing measures and highlighting methodological issues that require additional attention. METHODS: We searched for published studies (1973-2013) in 11 bibliographic databases for quantitative, empirical studies that presented outcome data related to adoption and/or implementation of an innovation...
August 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28832927/innovation-in-a-learning-health-care-system-veteran-directed-home-and-community-based-services
#20
Melissa M Garrido, Richard M Allman, Steven D Pizer, James L Rudolph, Kali S Thomas, Nina R Sperber, Courtney H Van Houtven, Austin B Frakt
A path-breaking example of the interplay between geriatrics and learning healthcare systems is the Veterans Health Administration's (VHA's) planned roll-out of a program for providing participant-directed home- and community-based services to veterans with cognitive and functional limitations. We describe the design of a large-scale, stepped-wedge, cluster-randomized trial of the Veteran-Directed Home- and Community-Based Services (VD-HCBS) program. From March 2017 through December 2019, up to 77 Veterans Affairs Medical Centers will be randomized to times to begin offering VD-HCBS to veterans at risk of nursing home placement...
August 21, 2017: Journal of the American Geriatrics Society
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