keyword
https://read.qxmd.com/read/38537129/the-association-between-mean-arterial-pressure-and-acute-kidney-injury-reversal-among-decompensated-cirrhosis-patients
#1
JOURNAL ARTICLE
Giuseppe Cullaro, Andrew S Allegretti, Cynthia Fenton, Jin Ge, Kavish R Patidar, Jessica Rubin, Arjun Sharma, Jennifer C Lai
BACKGROUND: This study informs how mean arterial pressure (MAP) impacts AKI recovery among all patients hospitalized with cirrhosis, regardless of etiology. METHODS: We identified incident AKI episodes among subjects in our cohort of decompensated cirrhosis patients. AKI was defined as a ≥50% increase in creatinine (sCr) from an outpatient baseline (≥7 days prior) that required hospitalization. Linear mixed-effects models were completed to determine the impact between AKI recovery, MAP, and time...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537069/controversies-in-terlipressin-and-transplantation-in-the-united-states-how-do-we-meld-the-two
#3
JOURNAL ARTICLE
Eric M Przybyszewski, Robert M Wilechansky, Paige McLean Diaz, Andrew S Allegretti, Lisa B VanWagner, Giuseppe Cullaro, Josh Levitsky, Pere Ginès, Salvatore Piano, Sumeet K Asrani, Kavish R Patidar
Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a severe complication of cirrhosis that carries a poor prognosis. The recent Food and Drug Administration approval of terlipressin has substantial implications for managing HRS-AKI and liver allocation in the United States (US). Terlipressin has been available in Europe for over a decade, and several countries have adapted policy changes such as Model for End-Stage Liver Disease (MELD) score "lock" for HRS-AKI. In this article, we outline the European experience with terlipressin use and explore the question of whether terlipressin treatment for HRS-AKI should qualify for MELD score "lock" in the US in those who respond to therapy...
March 28, 2024: Liver Transplantation
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#4
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#5
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#6
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38536468/traumatic-rhabdomyolysis-rare-but-morbid-potentially-lethal-and-inconsistently-monitored
#7
JOURNAL ARTICLE
Thomas Giles, Kate King, Simone Meakes, Natasha Weaver, Zsolt J Balogh
PURPOSE: Although traumatic rhabdomyolysis (TR) is shown to be associated with acute kidney injury (AKI), there are no large prospective epidemiological studies, interventional trials, official guidelines outlining the appropriate investigation, monitoring, and treatment on this poorly understood condition. We aimed to establish the contemporary epidemiology and describe current practices for TR to power future higher quality studies. We hypothesised that investigation and monitoring occur in an ad hoc fashion...
March 27, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38535488/outpatient-mean-arterial-pressure-a-potentially-modifiable-risk-for-acute-kidney-injury-and-death-among-cirrhosis-patients
#8
JOURNAL ARTICLE
Giuseppe Cullaro, Sy Han Chiou, Cynthia Fenton, Jin Ge, Charles E McCulloch, Jessica Rubin, Amy M Shui, Frederick Yao, Jennifer C Lai
BACKGROUND: Mean arterial blood pressure (MAP), which decreases as portal hypertension progresses, may be a modifiable risk factor among cirrhosis patients. METHODS: We included adults enrolled in the FrAILT study. We completed latent class trajectory analyses (LCTA) to define MAP trajectories. We completed time-dependent Cox-regression analyses to test the association between outpatient MAP and 3 cirrhosis-related outcomes: 1) Stage 2 acute kidney injury (AKI), defined as a ≥200% increase in serum creatinine from baseline; 2) a 5-point increase in the MELDNa score, defined as the incidence of increase from initial MELDNa; 3) waitlist mortality (WLM), defined as death on the WL...
March 27, 2024: Liver Transplantation
https://read.qxmd.com/read/38534731/dual-immunoglobulin-domain-containing-cell-adhesion-molecule-increases-early-in-renal-tubular-cell-injury-and-plays-anti-inflammatory-role
#9
JOURNAL ARTICLE
Jin Han, Ju-Min Yook, Se-Hyun Oh, Yu Kyung Chung, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Seungwoo Han, Jeong-Hoon Lim
Dual immunoglobulin domain-containing cell adhesion molecule (DICAM) is a type I transmembrane protein that presents in various cells including renal tubular cells. This study evaluated the expression and protective role of DICAM in renal tubular cell injury. HK-2 cells were incubated and treated with lipopolysaccharide (LPS, 30 μg/mL) or hydrogen peroxide (H2 O2 , 100 μM) for 24 h. To investigate the effect of the gene silencing of DICAM, small interfering RNA of DICAM was used. Additionally, to explain its role in cellular response to injury, DICAM was overexpressed using an adenoviral vector...
February 26, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534369/potential-utility-of-urinary-follistatin-as-a-non-invasive-indicator-of-acute-tubular-damage-in-patients-with-acute-kidney-injury
#10
JOURNAL ARTICLE
Izumi Nagayama, Kaori Takayanagi, Daisuke Nagata, Hajime Hasegawa, Akito Maeshima
Activin A is known to impede tubular repair following renal ischemia, whereas exogenous follistatin, an activin A antagonist, has been shown to ameliorate kidney damage in rats. Despite these findings, the precise role of endogenous follistatin in the kidney has yet to be elucidated. In this study, we investigated the localization of follistatin in the normal human kidney and its potential utility as a marker for acute kidney injury (AKI). In a total of 118 AKI patients and 16 healthy adults, follistatin levels in serum and urine were quantified using ELISA, and correlations with clinical parameters were analyzed...
March 16, 2024: Cells
https://read.qxmd.com/read/38533999/vancomycin-auc-0-24-estimation-using-first-order-pharmacokinetic-methods-in-pediatric-patients
#11
JOURNAL ARTICLE
Hope H Brandon, David S Burgess, Katie L Wallace, Elizabeth B Autry, Katie B Olney
INTRODUCTION: The optimal dosing and monitoring of vancomycin in pediatrics is still unknown but has evolved to emphasize area under the curve over 24 h (AUC0-24 ) over minimum concentration (Cmin ) monitoring. Real-world data supporting the feasibility of two-concentration kinetics with first-order equations for the estimation of vancomycin AUC0-24 in pediatric patients are lacking. OBJECTIVES: To describe the interplay of vancomycin dose, AUC0-24 , and Cmin using first-order equations within four pediatric age groups...
March 27, 2024: Pharmacotherapy
https://read.qxmd.com/read/38533944/risk-score-for-prediction-of-dialysis-after-transcatheter-aortic-valve-replacement
#12
JOURNAL ARTICLE
Vincenzo Pasceri, Francesco Pelliccia, Roxana Mehran, George Dangas, Italo Porto, Francesco Radico, Fausto Biancari, Fabrizio D'Ascenzo, Francesco Saia, Giampaolo Luzi, Francesco Bedogni, Ignacio J Amat Santos, Vincenzo De Marzo, Arnaldo Dimagli, Timo Mäkikallio, Eugenio Stabile, Sara Blasco-Turrión, Luca Testa, Marco Barbanti, Corrado Tamburino, Franco Fabiocchi, Ahmed Chilmeran, Federico Conrotto, Giuliano Costa, Giulio Stefanini, Carmen Spaccarotella, Andrea Macchione, Michele La Torre, Francesco Bendandi, Tatu Juvonen, Wojciech Wańha, Wojtek Wojakowski, Umberto Benedetto, Ciro Indolfi, David Hildick-Smith, Marco Zimarino
BACKGROUND: Dialysis is a rare but serious complication after transcatheter aortic valve replacement. We analyzed the large multicenter TRITAVI (transfusion requirements in transcatheter aortic valve implantation) registry in order to develop and validate a clinical score assessing this risk. METHODS AND RESULTS: A total of 10 071 consecutive patients were enrolled in 19 European centers. Patients were randomly assigned (2:1) to a derivation and validation cohort...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533295/hemodynamic-determinants-of-cardiac-surgery-associated-acute-kidney-injury
#13
JOURNAL ARTICLE
Sevag Demirjian, Faisal Bakaeen, W H Wilson Tang, Chase Donaldson, Jon Taliercio, Anne Huml, Crystal A Gadegbeku, A Marc Gillinov, Steven Insler
OBJECTIVES: Examine the: 1) relative role of hemodynamic determinants of acute kidney injury (AKI) obtained in the immediate postcardiac surgery setting compared with established risk factors, 2) their predictive value, and 3) extent mediation via central venous pressure (CVP) and mean arterial pressure (MAP). DESIGN: Retrospective observational study. The main outcome of the study was moderate to severe AKI, per kidney disease: improving global outcomes, within 14 days of surgery...
April 2024: Critical care explorations
https://read.qxmd.com/read/38533293/a-new-dosing-frontier-retrospective-assessment-of-effluent-flow-rates-and-residual-renal-function-among-critically-ill-patients-receiving-continuous-renal-replacement-therapy
#14
JOURNAL ARTICLE
Damini Lakshmipathy, Xiaoyi Ye, Joseph L Kuti, David P Nicolau, Tomefa E Asempa
OBJECTIVES: In 2020, cefiderocol became the first Food and Drug Administration-approved medication with continuous renal replacement therapy (CRRT) dosing recommendations based on effluent flow rates ( Q E ). We aimed to evaluate the magnitude and frequency of factors that may influence these recommendations, that is, Q E intrapatient variability and residual renal function. DESIGN: Retrospective observational cohort study. SETTING: ICUs within Hartford Hospital (890-bed, acute-care hospital) in Connecticut from 2017 to 2023...
April 2024: Critical care explorations
https://read.qxmd.com/read/38532810/letter-to-the-editor-comment-on-association-between-premorbid-renin-angiotensin-aldosteron-system-blockade-and-the-risk-of-acute-kidney-injury-in-critically-ill-patients
#15
JOURNAL ARTICLE
https://read.qxmd.com/read/38531708/in-hospital-outcomes-and-trends-of-patients-with-autoimmune-diseases-undergoing-percutaneous-coronary-intervention-a-nationwide-analysis
#16
JOURNAL ARTICLE
Akanimo Antia, Kessiena Aomreore, Ndausung Udongwo, Sharika Menon, Uzoma Ibebuogu
BACKGROUND: The risk of coronary artery disease is exaggerated in patients with autoimmune diseases (AID). A higher risk of complications has been reported during and after percutaneous coronary intervention (PCI) in these patients. We aimed to analyze the in-hospital outcomes and trends of patients with AID, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) undergoing PCI. METHOD: We identified all PCI procedures using the National In-patient Sample database from 2016 to 2020...
March 9, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38531618/high-sensitive-troponint-interleukin-8-and-interleukin-6-link-with-post-surgery-risk-in-infant-heart-surgery
#17
JOURNAL ARTICLE
Elin M Thorlacius, Juho Keski-Nisula, Maria Vistnes, Tiina Ojala, Mattias Molin, Mats Synnergren, Birgitta S Romlin, Sven-Erik Ricksten, Håkan Wåhlander, Albert Gyllencreutz Castellheim
BACKGROUND: This study focuses on biomarkers in infants after open heart surgery, and examines the association of high-sensitive troponin T (hs-cTnT), interleukin-6 (IL-6), and interleukin-8 (IL-8) with postoperative acute kidney injury (AKI), ventilatory support time and need of vasoactive drugs. METHODS: Secondary exploratory study from a double-blinded clinical randomized trial (Mile-1) on 70 infants undergoing open heart surgery with cardiopulmonary bypass (CPB)...
March 26, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38531564/investigation-of-renal-perfusion-and-pathological-changes-in-patients-with-acute-kidney-disease-and-tubulointerstitial-nephritis-using-intravoxel-incoherent-motion-and-arterial-spin-labelling-mri-a-prospective-observational-study-protocol
#18
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531329/treatment-and-long-term-safety-outcomes-of-peptide-receptor-radionuclide-therapy-for-metastatic-neuroendocrine-tumours-an-asian-experience
#19
JOURNAL ARTICLE
Wei Ying Tham, Hian Liang Huang, David Wai Meng Tai, John C Allen, Jacqueline S G Hwang, Lih Ming Loh, Brian K P Goh, Simon Y K Ong, Peng Chin Kek, Damien M Y Tan, David C E Ng, Kelvin S H Loke
Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population...
March 26, 2024: Neuroendocrinology
https://read.qxmd.com/read/38530649/iatrogenic-hyperchloremia-an-overview-in-hospitalized-patients-for-pharmacists
#20
JOURNAL ARTICLE
Amoreena Most, Sarah Nordbeck, Nicholas Farina
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: The purpose of this therapeutic update is to provide pharmacists with a general overview of the pathophysiology of hyperchloremia and describe strategies to help prevent development of this electrolyte abnormality in hospitalized patients...
March 26, 2024: American Journal of Health-system Pharmacy: AJHP
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