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https://www.readbyqxmd.com/read/28922764/a-pentatricopeptide-repeat-protein-restores-nap-cytoplasmic-male-sterility-in-brassica-napus
#1
Zhi Liu, Faming Dong, Xiang Wang, Tao Wang, Rui Su, Dengfeng Hong, Guangsheng Yang
Two forms of male-sterile cytoplasm, designated nap and pol, are found in the oilseed rape species, Brassica napus. The nap cytoplasm is observed in most B. napus varieties, and it confers male sterility on a limited number of cultivars that lack the corresponding restorer gene, Rfn. In the present study, using linkage analysis in combination with 5652 BC1 progeny derived from a cross between a nap cytoplasmic male sterility (CMS) line 181A and a restorer line H5, we delimited the Rfn gene to a 10.5 kb region on chromosome A09, which contained three putative ORFs...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28900922/tissue-specificity-the-role-of-organellar-membrane-nanojunctions-in-smooth-muscle-ca-2-signaling
#2
Nicola Fameli, A Mark Evans, Cornelis van Breemen
In this chapter we examine the importance of cytoplasmic nanojunctions-nanometer scale appositions between organellar membranes including the molecular transporters therein-to the cell signaling machinery, with specific reference to Ca(2+) transport and signaling in vascular smooth muscle and endothelial cells. More specifically, we will consider the extent to which quantitative modeling may aid in the development of our understanding of these processes. Testament to the requirement for such approaches lies in the fact that recent studies have provided evermore convincing evidence in support of the view that cytoplasmic nanospaces may be as significant to the process of Ca(2+) signaling as the Ca(2+) transporters, release channels, and Ca(2+)-storing organelles themselves...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28891316/associations-of-the-abca1-and-lpl-gene-polymorphisms-with-lipid-levels-in-a-hyperlipidemic-population
#3
Fang Tao, Justin Weinstock, Scott A Venners, Jun Cheng, Yi-Hsiang Hsu, Yanfeng Zou, Faming Pan, Shanqun Jiang, Xiangdong Zha, Xiping Xu
We conducted a cross-sectional study to investigate the effects of the adenosine triphosphate-binding cassette transporter 1 (ABCA1) I883M and lipoprotein lipase (LPL) HindIII polymorphisms on lipid levels in patients with hyperlipidemia. A total of 533 patients were enrolled. Serum lipid parameters were determined by an automatic biochemistry analyzer. Genotyping of the ABCA1 I883M and LPL HindIII was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Multiple linear regression analysis was used to estimate the associations between serum lipid levels and the genetic polymorphisms...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28889235/genotoxic-potential-of-diesel-exhaust-particles-from-the-combustion-of-first-and-second-generation-biodiesel-fuels-the-fuelhealth-project
#4
Magdalena Kowalska, Aneta Wegierek-Ciuk, Kamil Brzoska, Maria Wojewodzka, Sylwia Meczynska-Wielgosz, Joanna Gromadzka-Ostrowska, Remigiusz Mruk, Johan Øvrevik, Marcin Kruszewski, Anna Lankoff
Epidemiological data indicate that exposure to diesel exhaust particles (DEPs) from traffic emissions is associated with higher risk of morbidity and mortality related to cardiovascular and pulmonary diseases, accelerated progression of atherosclerotic plaques, and possible lung cancer. While the impact of DEPs from combustion of fossil diesel fuel on human health has been extensively studied, current knowledge of DEPs from combustion of biofuels provides limited and inconsistent information about its mutagenicity and genotoxicity, as well as possible adverse health risks...
September 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28876392/antifungal-and-antioxidant-activity-of-fatty-acid-methyl-esters-from-vegetable-oils
#5
Maria E A Pinto, Sthéfane G Araújo, Marcela I Morais, Nívea P Sá, Caroline M Lima, Carlos A Rosa, Ezequias P Siqueira, Susana Johann, Luciana A R S Lima
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28841785/biodiesel-synthesis-using-chicken-manure-biochar-and-waste-cooking-oil
#6
Jong-Min Jung, Sang-Ryong Lee, Jechan Lee, Taewoo Lee, Daniel C W Tsang, Eilhann E Kwon
This study laid an emphasis on the possible employment of biochar generated from pyrolysis of chicken manure to establish a green platform for producing biodiesel. To this end, the pseudo-catalytic transesterification reaction using chicken manure biochar and waste cooking oil was investigated. Compared with a commercial porous material (SiO2), chicken manure biochar generated from 350°C showed better performance, resulting in 95.6% of the FAME yield at 350°C. The Ca species in chicken manure biochar imparted strong catalytic capability by providing the basicity for transesterification...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28835979/-instantaneous-wave-free-ratio-ifr%C3%A2-in-patients-with-coronary-artery-disease
#7
REVIEW
S Baumann, A C Schaefer, A Hohneck, K Mueller, T Becher, M Behnes, M Renker, M Borggrefe, I Akin, D Lossnitzer
Coronary angiography is considered as the gold standard in the morphological representation of coronary artery stenosis. Coronary angiography is often performed without preprocedural non-invasive proof of ischemia and the assessment of the severity of a coronary lesion by morphology is very subjective. Thus, invasive fractional flow reserve (FFR) measurement represents the current standard for estimation of the hemodynamic relevance of coronary artery stenosis and facilitates decision making for percutaneous coronary intervention (PCI) and stenting...
August 23, 2017: Herz
https://www.readbyqxmd.com/read/28803399/blood-purine-measurements-as-a-rapid-real-time-indicator-of-reversible-brain-ischaemia
#8
Faming Tian, Fakhra Bibi, Nicholas Dale, Christopher H E Imray
To preserve the disequilibrium between ATP and ADP necessary to drive cellular metabolism, enzymatic pathways rapidly convert ADP to adenosine and the downstream purines inosine and hypoxanthine. During ischaemia, these same pathways result in the production of purines. We performed a prospective observational study to test whether purine levels in arterial blood might correlate with brain ischaemia. We made real-time perioperative measurements, via microelectrode biosensors, of the purine levels in untreated arterial blood from 18 patients undergoing regional anaesthetic carotid endarterectomy...
August 12, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28796069/assessment-of-therapeutic-response-in-crohn-s-disease-using-quantitative-dynamic-contrast-enhanced-mri-dce-mri-parameters-a-preliminary-study
#9
Jianguo Zhu, Faming Zhang, Jinfa Zhou, Haige Li
The aim of the study was to investigate dynamic contrast enhanced MRI (DCE-MRI) as a potential marker to assess the therapeutic responses of fecal microbiota transplantation (FMT) in patients with Crohn's disease (CD) and to determine the parameter or combination of parameters most strongly associated with changes in clinical indicators after treatment.In 22 CD patients, DCE-MRI was performed with a 3.0T scanner. Parameters of DCE-MRI (vascular transfer constant [K] and blood volume [BV]) in the terminal ileum were compared between before and day 90 after FMT treatment...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28771748/extraction-of-unsaturated-fatty-acid-rich-oil-from-common-carp-cyprinus-carpio-roe-and-production-of-defatted-roe-hydrolysates-with-functional-antioxidant-and-antibacterial-properties
#10
Sakhi Ghelichi, Bahareh Shabanpour, Parastoo Pourashouri, Mona Hajfathalian, Charlotte Jacobsen
BACKGROUND: Common carp roe is a rich protein and oil source, which is usually discarded with no specific use. The aims of this study were to extract oil from the discarded roe and examine functional, antioxidant, and antibacterial properties of defatted roe hydrolysates (CDRHs) at various degrees of hydrolysis (DH). RESULTS: Gas chromatography (GC) of fatty acid methyl esters (FAMEs) revealed that common carp roe oil contained high level of unsaturated fatty acids...
August 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28764565/fluocinolone-acetonide-for-the-treatment-of-diabetic-macular-edema
#11
Daniele Veritti, Valentina Sarao, Laura Diplotti, Francesco Samassa, Paolo Lanzetta
Fluocinolone acetonide intravitreal implant is a non-erodible implant approved for the treatment of diabetic macular edema (DME) insufficiently responsive to available therapies. Areas covered: The injectable intravitreal implant releases fluocinolone acetonide at an average rate of 0.2 µg/day for at least 36 months. The two pooled pivotal FAME trials showed that, in patients with DME previously treated with laser photocoagulation, fluocinolone acetonide intravitreal implant was more beneficial than sham injection when looking at the proportion of patients with an improvement from baseline in visual acuity of more than 15 letters at 24 months and at 36 months...
October 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28738595/compound-specific-%C3%AE-13-c-and-%C3%AE-2-h-analysis-of-olive-oil-fatty-acids
#12
Mauro Paolini, Luana Bontempo, Federica Camin
Fatty acids are the most abundant biomolecules in olive oil. In this study, we describe the analytical method developed to measure the δ(13)C, and for the first time, the δ(2)H values of fatty acid methyl esters (FAMEs) extracted from olive oil triglycerides, after base-catalysed transesterification with methanol. The extracted FAMEs are analysed using Gas Chromatography Combustion/Pyrolysis Isotope Ratio Mass Spectrometry (GC-C/Py-IRMS). The method made it possible to obtain baseline separation between the peaks of the main FAMEs (C16, C18, C18:1, C18:2)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737758/real-world-experience-with-0-2%C3%A2-%C3%AE-g-day-fluocinolone-acetonide-intravitreal-implant-iluvien-in-the-united-kingdom
#13
C Bailey, U Chakravarthy, A Lotery, G Menon, J Talks
AimsTo compare safety outcomes and visual function data acquired in the real-world setting with FAME study results in eyes treated with 0.2 μg/day fluocinolone acetonide (FAc).MethodsFourteen UK clinical sites contributed to pseudoanonymised data collected using the same electronic medical record system. Data pertaining to eyes treated with FAc implant for diabetic macular oedema (DMO) was extracted. Intraocular pressure (IOP)-related adverse events were defined as use of IOP-lowering medication, any rise in IOP>30 mm Hg, or glaucoma surgery...
July 24, 2017: Eye
https://www.readbyqxmd.com/read/28721615/phycoremediation-potential-of-marine-microalga-tetraselmis-indica-on-secondary-treated-domestic-sewage-for-nutrient-removal-and-biodiesel-production
#14
Amit, Rajesh Chandra, Uttam Kumar Ghosh, Jagdeep Kumar Nayak
Marine microalga Tetraselmis indica (T. indica) was cultivated in secondary treated domestic sewage (STDS) in batch mode. Optimization studies showed that after 14 days of cultivation period, highest biomass yield reached was 0.88 ± 0.04 g/L at the optimum temperature of 27 ± 1 °C and light intensity of 135 μmol m(-2) s(-1). T. indica removed about 60.93% phosphate, 78.46% nitrate, 72.94% chemical oxygen demand (COD), 73.17% biological oxygen demand (BOD), 98.90% total dissolved solids (TDS) and heavy metals (83...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28716697/copy-number-variations-of-the-il-22-gene-are-associated-with-ankylosing-spondylitis-a-case-control-study-in-chinese-han-population
#15
Xu Zhang, Xiaona Li, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Rui Li, Xiao Yang, Qing Xia, Yubo Ma, Jiajia Yang, Jingjing Tong, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Faming Pan
IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopy™ methods in a cohort of 649 AS patients and 628 controls. Association of IL-22 CNVs and AS susceptibility was analyzed, and AS risk was estimated by Odds Ratio (ORs) and 95% confidence intervals (CIs), and the Benjamini-Hochberg method was applied to regulate the false discovery rate (FDR)...
July 14, 2017: Human Immunology
https://www.readbyqxmd.com/read/28692339/motivations-for-selling-ecstasy-among-young-adults-in-the-electronic-dance-music-club-culture-in-brazil
#16
Lysa S Remy, Mance E Buttram, Steven P Kurtz, Hilary L Surratt, Flavio Pechansky
This article describes data on the motivations for selling ecstasy among young adults in the electronic dance music (EDM) club culture in Brazil. Individual interviews were conducted with 20 individuals recruited for their involvement in the EDM club scene. Eligible participants were aged 18-39 and reported ecstasy and/or LSD use one or more times in the past 90 days. Exclusion criteria included current treatment for drug/alcohol problems and cognitive impairment or clinically evident psychiatric disorder...
July 10, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28688796/fatty-acid-based-lipidomics-and-membrane-remodeling-induced-by-apoe3-and-apoe4-in-human-neuroblastoma-cells
#17
Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu
Apolipoprotein E (apoE) is a major lipid carrier of the lipoprotein transport system that plays critical roles in various pathologies. Human apoE has three common isoforms, the apoE4 being associated with Alzheimer's disease. This is the first study in the literature investigating the effects of apoE (apoE3 and apoE4 isoforms) on membrane fatty acid profile in neuroblastoma SK-N-SH cells. Fatty acid analyses were carried out by gas chromatography of the corresponding methyl esters (FAME). We observed the occurrence of membrane fatty acid remodeling in the presence of each of the two apoE isoforms...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28687189/regulatory-effect-of-fe-edta-on-mixotrophic-cultivation-of-chlorella-sp-towards-biomass-growth-and-metabolite-production
#18
Rajesh Kona, Manupati Hemalatha, K Venu Srivastav, S Venkata Mohan
The study examined the effect of varying concentrations of iron in the form of ethylene diamine tetra-acetic acid ferric sodium salt (Fe-EDTA) for cultivation of Chlorella sp. under mixotrophic condition to evaluate biomass growth and metabolites production. The experimental data depicted enhanced biomass production along with lipids, carbohydrates and proteins at an optimal iron concentration (8mg/L). Relatively higher biomass production (5.4g/L; 96h) with simultaneous total chlorophyll (5mg/mL (Chl a/b: 3...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28684845/multiple-fresh-fecal-microbiota-transplants-induces-and-maintains-clinical-remission-in-crohn-s-disease-complicated-with-inflammatory-mass
#19
Zhi He, Pan Li, Jianguo Zhu, Bota Cui, Lijuan Xu, Jie Xiang, Ting Zhang, Chuyan Long, Guangming Huang, Guozhong Ji, Yongzhan Nie, Kaichun Wu, Daiming Fan, Faming Zhang
The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn's disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680410/do-the-powerful-discount-the-future-less-the-effects-of-power-on-temporal-discounting
#20
Jinyun Duan, Sherry J Wu, Luying Sun
Individuals have the tendency to discount rewards in the future, known as temporal discounting, and we find that sense of power (the felt capacity to influence the thinking and behavior of others) reduces such tendency. In Studies 1 and 2, we used both an experiment and a survey with organizational employees to demonstrate that power reduced temporal discounting. In Study 3, we replicated study 1 while exploring a unique cultural trait of Danbo, or indifference to fame and wealth, across two ethnic groups (Han and Tibetan groups) in China...
2017: Frontiers in Psychology
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