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https://www.readbyqxmd.com/read/28716697/copy-number-variations-of-the-il-22-gene-are-associated-with-ankylosing-spondylitis-a-case-control-study-in-chinese-han-population
#1
Xu Zhang, Xiaona Li, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Rui Li, Xiao Yang, Qing Xia, Yubo Ma, Jiajia Yang, Jingjing Tong, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Faming Pan
IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopy(TM) methods in a cohort of 649 AS patients and 628 controls. Association of IL-22 CNVs and AS susceptibility was analyzed, and AS risk was estimated by Odds Ratio (ORs) and 95% confidence intervals (CIs), and the Benjamini-Hochberg method was applied to regulate the false discovery rate (FDR)...
July 14, 2017: Human Immunology
https://www.readbyqxmd.com/read/28692339/motivations-for-selling-ecstasy-among-young-adults-in-the-electronic-dance-music-club-culture-in-brazil
#2
Lysa S Remy, Mance E Buttram, Steven P Kurtz, Hilary L Surratt, Flavio Pechansky
This article describes data on the motivations for selling ecstasy among young adults in the electronic dance music (EDM) club culture in Brazil. Individual interviews were conducted with 20 individuals recruited for their involvement in the EDM club scene. Eligible participants were aged 18-39 and reported ecstasy and/or LSD use one or more times in the past 90 days. Exclusion criteria included current treatment for drug/alcohol problems and cognitive impairment or clinically evident psychiatric disorder...
July 10, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28688796/fatty-acid-based-lipidomics-and-membrane-remodeling-induced-by-apoe3-and-apoe4-in-human-neuroblastoma-cells
#3
Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu
Apolipoprotein E (apoE) is a major lipid carrier of the lipoprotein transport system that plays critical roles in various pathologies. Human apoE has three common isoforms, the apoE4 being associated with Alzheimer's disease. This is the first study in the literature investigating the effects of apoE (apoE3 and apoE4 isoforms) on membrane fatty acid profile in neuroblastoma SK-N-SH cells. Fatty acid analyses were carried out by gas chromatography of the corresponding methyl esters (FAME). We observed the occurrence of membrane fatty acid remodeling in the presence of each of the two apoE isoforms...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28687189/regulatory-effect-of-fe-edta-on-mixotrophic-cultivation-of-chlorella-sp-towards-biomass-growth-and-metabolite-production
#4
Rajesh Kona, Manupati Hemalatha, K Venu Srivastav, S Venkata Mohan
The study examined the effect of varying concentrations of iron in the form of ethylene diamine tetra-acetic acid ferric sodium salt (Fe-EDTA) for cultivation of Chlorella sp. under mixotrophic condition to evaluate biomass growth and metabolites production. The experimental data depicted enhanced biomass production along with lipids, carbohydrates and proteins at an optimal iron concentration (8mg/L). Relatively higher biomass production (5.4g/L; 96h) with simultaneous total chlorophyll (5mg/mL (Chl a/b: 3...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28684845/multiple-fresh-fecal-microbiota-transplants-induces-and-maintains-clinical-remission-in-crohn-s-disease-complicated-with-inflammatory-mass
#5
Zhi He, Pan Li, Jianguo Zhu, Bota Cui, Lijuan Xu, Jie Xiang, Ting Zhang, Chuyan Long, Guangming Huang, Guozhong Ji, Yongzhan Nie, Kaichun Wu, Daiming Fan, Faming Zhang
The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn's disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680410/do-the-powerful-discount-the-future-less-the-effects-of-power-on-temporal-discounting
#6
Jinyun Duan, Sherry J Wu, Luying Sun
Individuals have the tendency to discount rewards in the future, known as temporal discounting, and we find that sense of power (the felt capacity to influence the thinking and behavior of others) reduces such tendency. In Studies 1 and 2, we used both an experiment and a survey with organizational employees to demonstrate that power reduced temporal discounting. In Study 3, we replicated study 1 while exploring a unique cultural trait of Danbo, or indifference to fame and wealth, across two ethnic groups (Han and Tibetan groups) in China...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28673659/joseph-jumenti%C3%A3-1879-1928-a-forgotten-neurologist
#7
REVIEW
O Walusinski
Joseph Jumentié (1879-1928), through his clinical skill and expertise in anatomical pathology, enhanced the prestige of the master neurologists he studied under- Jules Dejerine, Augusta Dejerine-Klumpke and Joseph Babiński -and their fame overshadowed the crucial support that Jumentié provided them. Following a remarkable doctoral thesis in 1911, which defined the semiology of tumors in the cerebellopontine angle, Jumentié conducted research into various areas of neurology and authored numerous publications...
June 30, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28667165/association-between-the-autophagy-related-gene-ulk1-and-ankylosing-spondylitis-susceptibility-in-the-chinese-han-population-a-case-control-study
#8
Xu Zhang, Renfang Han, Mengmeng Wang, Xiaona Li, Xiao Yang, Qing Xia, Rui Liu, Yaping Yuan, Xingxing Hu, Mengya Chen, Guangming Jiang, Yubo Ma, Jiajia Yang, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Faming Pan
PURPOSE: Ankylosing spondylitis (AS), inflammatory bowel disease and Crohn's disease (CD) often coexist in the same patient and these diseases have remarkably strong overlaps in genetic association. The association between Unc51like kinase 1 (ULK1) gene polymorphisms and CD has been reported, and the aim of the current study was to investigate whether ULK1 polymorphisms are also associated with susceptibility to AS in the Chinese Han population. METHODS: Five tagging single nucleotide polymorphisms in the ULK1 gene (rs9652059, rs11616018, rs12303764, rs4964879 and rs7300908) were genotyped by the improved multiplex ligase detection reaction method in a cohort of patients with AS (n=649) and controls (n=628)...
June 30, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28655159/two-distinct-metacommunities-characterize-the-gut-microbiota-in-crohn-s-disease-patients
#9
Qing He, Yuan Gao, Zhuye Jie, Xinlei Yu, Janne Marie Laursen, Liang Xiao, Ying Li, Lingling Li, Faming Zhang, Qiang Feng, Xiaoping Li, Jinghong Yu, Chuan Liu, Ping Lan, Ting Yan, Xin Liu, Xun Xu, Huanming Yang, Jian Wang, Lise Madsen, Susanne Brix, Jianping Wang, Karsten Kristiansen, Huijue Jia
Background: The inflammatory intestinal disorder Crohn's disease (CD) has become a health challenge worldwide. The gut microbiota closely interacts with the host immune system, but its functional impact in CD is unclear. Except for studies on a small number of CD patients, analyses of the gut microbiota in CD have used 16S rDNA amplicon sequencing. Here we employed metagenomic shotgun sequencing to provide a detailed characterization of the compositional and functional features of the CD microbiota, comprising also unannotated bacteria, and investigated its modulation by exclusive enteral nutrition (EEN)...
June 26, 2017: GigaScience
https://www.readbyqxmd.com/read/28649113/american-av-edgar-dale-and-the-information-age-classroom
#10
Charles R Acland
This article demonstrates how the influential scholar Edgar Dale, alongside a generation of educational technologists, helped build an essential place for AV materials and pedagogical methods in the American classroom. It also shows that, for decades, the Payne Fund philanthropy supported multimedia research agendas that shaped ideas about teaching and technology, far beyond involvement in their famed studies on motion pictures and children in the 1930s. With his writings and research programs, Dale advanced concepts of media experience and systematicity, which came to be understood as common sense to the information society...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28639807/the-impact-of-time-and-repeated-exposure-on-famous-person-knowledge-in-amnestic-mild-cognitive-impairment-and-alzheimer-s-disease
#11
Sophie Benoit, Isabelle Rouleau, Roxane Langlois, Valérie Dostie, Marie-Jeanne Kergoat, Sven Joubert
OBJECTIVE: Famous people knowledge has been shown to be impaired early in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However, the question of whether recently acquired knowledge is more impaired than remotely acquired knowledge remains a matter of debate. The aim of this study was to investigate the patterns of semantic memory impairment in aMCI and AD by investigating 2 factors that may influence the retrieval of such knowledge, namely remoteness and frequency of repetition of information over time...
June 22, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28628981/biodiesel-synthesis-from-calophyllum-inophyllum-oil-with-different-supercritical-fluids
#12
Neha Lamba, Kaveri Gupta, Jayant M Modak, Giridhar Madras
Biodiesel or fatty acid methyl esters (FAMEs) is primarily synthesized using edible vegetable oils and methanol with a catalyst. However, in the present study, FAMEs were synthesized from a non-edible oil (Calophyllum inophyllum also called as sura honne, Punnagam, Alexandrian Laurel) in different supercritical fluids: methanol (MeOH), methyl tert-butyl ether (MTBE), methyl acetate (MeOAc) and dimethyl carbonate (DMC) non-catalytically. Reactions were performed from 523K to 673K at 30MPa with a molar ratio of 40:1 with times varying from 3min to 3h...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28624246/uv-c-irradiation-accelerates-neutral-lipid-synthesis-in-the-marine-oleaginous-diatom-fistulifera-solaris
#13
Atsushi Arakaki, Takuya Matsumoto, Takuma Tateishi, Mitsufumi Matsumoto, Daisuke Nojima, Yoshino Tomoko, Tsuyoshi Tanaka
This study investigated the induction of oil synthesis in the oleaginous diatom, Fistulifera solaris, following irradiation with small doses of UV-C. A rapid induction of oil accumulation was confirmed within 6h following UV-C radiation of the diatom cells, with increases in cell oil body volumes after 24h of approximately 4- to 6-fold from the initial volume. Reactive oxygen species (ROS), which can be generated by a UV-C-mediated reaction, were detected in irradiated cells and the correlation between ROS generation and oil accumulation was confirmed...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28615918/lung-cancer-pathological-image-analysis-using-a-hidden-potts-model
#14
Qianyun Li, Faliu Yi, Tao Wang, Guanghua Xiao, Faming Liang
Nowadays, many biological data are acquired via images. In this article, we study the pathological images scanned from 205 patients with lung cancer with the goal to find out the relationship between the survival time and the spatial distribution of different types of cells, including lymphocyte, stroma, and tumor cells. Toward this goal, we model the spatial distribution of different types of cells using a modified Potts model for which the parameters represent interactions between different types of cells and estimate the parameters of the Potts model using the double Metropolis-Hastings algorithm...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28604970/-study-of-the-molecular-basis-for-an-individual-with-bel-variant-due-to-deletion-of-b-glycosyltransferase-gene
#15
Yanling Ying, Xiaozhen Hong, Shu Chen, Xianguo Xu, Kairong Ma, Xiaofei Lan, Ji He, Faming Zhu
OBJECTIVE: To explore the molecular basis of an individual with Bel variant of the ABO blood group. METHODS: The ABO antigen and serum antibody of the individual were detected by serological method. All coding regions and flanking introns of the ABO gene were amplified with PCR and sequenced bidirectionally. The haplotypes of the individual were analyzed by cloning and sequencing. A three dimensional model of the mutant protein was constructed and analyzed. RESULTS: The individual has expressed a very weak B antigen on its red blood cells by absorption and elution testing, which was identified as a Bel variant phenotype...
June 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28588567/biofilm-vs-planktonic-lifestyle-consequences-for-pesticide-2-4-d-metabolism-by-cupriavidus-necator-jmp134
#16
Thomas Z Lerch, Claire Chenu, Marie F Dignac, Enrique Barriuso, André Mariotti
The development of bacterial biofilms in natural environments may alter important functions, such as pollutant bioremediation by modifying both the degraders' physiology and/or interactions within the matrix. The present study focuses on the influence of biofilm formation on the metabolism of a pesticide, 2,4-dichlorophenoxyacetic acid (2,4-D), by Cupriavidus necator JMP134. Pure cultures were established in a liquid medium with 2,4-D as a sole carbon source with or without sand grains for 10 days. Bacterial numbers and 2,4-D concentrations in solution were followed by spectrophotometry, the respiration rate by gas chromatography and the surface colonization by electron microscopy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28580860/the-effects-of-social-concern-goals-on-the-value-of-learning-and-on-the-intentions-of-medical-students-to-change-their-majors
#17
Soowon Park, Seunghee Cho, Jun-Young Lee
BACKGROUND: In the process of developing a professional medical expertise, goals can become a psychological impetus and act as a source of retaining an individual's persistency. Therefore, the goals of medical students should be considered when designing a curriculum for health professions. PURPOSE: The purpose of this study was to examine relative effects of goal categories on the value of learning and intention to change one's major. METHOD: Data were obtained from the Korea Education Longitudinal Study, which included 1938 representative Korean college freshmen majoring in medicine, engineering, natural science and humanities...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28571547/potential-of-macroalgae-ulva-lactuca-as-a-source-feedstock-for-biodiesel-production
#18
Hanaa H Abd El Baky, Gamal S El Baroty
BACKGROUND: The aim of this study was to investigate the possibility of growing of algae Ulva lactuca L under different salinity levels coupled with varied KNO3 concentrations (source of N) as a potential source of oil for biodiesel production. METHODS: U. lactuta was cultured in 10.0% NaCl coupled with either 2.5 g/L (S1+ 1N) or 1.0 g/L KNO3 (S1+ 2N) and in 30.0% NaCl coupled with 2.5 g/L (S2+ 1N) or 1.0 g/L KNO3 (S2+ 2N) nutrient medium. Among all algae cultures, biomass (dry weight) and lipid accumulation (total lipid content, TL) were significantly different (P>0...
June 1, 2017: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/28569156/how-chinese-clinicians-face-ethical-and-social-challenges-in-fecal-microbiota-transplantation-a-questionnaire-study
#19
Yonghui Ma, Jinqiu Yang, Bota Cui, Hongzhi Xu, Chuanxing Xiao, Faming Zhang
BACKGROUND: Fecal microbiota transplantation (FMT) is reportedly the most effective therapy for relapsing Clostridium Difficile infection (CDI) and a potential therapeutic option for many diseases. It also poses important ethical concerns. This study is an attempt to assess clinicians' perception and attitudes towards ethical and social challenges raised by fecal microbiota transplantation. METHODS: A questionnaire was developed which consisted of 20 items: four items covered general aspects, nine were about ethical aspects such as informed consent and privacy issues, four concerned social and regulatory issues, and three were about an FMT bank...
May 31, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28541721/a-joint-bayesian-model-for-integrating-microarray-and-rna-sequencing-transcriptomic-data
#20
Tianzhou Ma, Faming Liang, Steffi Oesterreich, George C Tseng
As the sequencing cost continued to drop in the past decade, RNA sequencing (RNA-seq) has replaced microarray to become the standard high-throughput experimental tool to analyze transcriptomic profile. As more and more datasets are generated and accumulated in the public domain, meta-analysis to combine multiple transcriptomic studies to increase statistical power has received increasing popularity. In this article, we propose a Bayesian hierarchical model to jointly integrate microarray and RNA-seq studies...
July 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
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