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https://www.readbyqxmd.com/read/28528605/fixed-combination-calcipotriene-plus-betamethasone-dipropionate-aerosol-foam-is-well-tolerated-in-patients-with-psoriasis-vulgaris-pooled-data-from-three-randomized-controlled-studies
#1
Alan Menter, Linda Stein Gold, John Koo, John Villumsen, Monika Rosén, Mark Lebwohl
The authors performed a pooled analysis of three randomized, 4-week, phase II/III studies in adult patients with mild to severe psoriasis and assessed the safety/tolerability of aerosol foam fixed-combination calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD) versus different comparators. Overall, 1104 patients were randomized to Cal/BD aerosol foam (n=564), Cal aerosol foam (n=101), BD aerosol foam (n=101), aerosol foam vehicle (n=152), Cal/BD ointment (n=135), or ointment vehicle (n=51)...
2017: Skinmed
https://www.readbyqxmd.com/read/28527272/-does-corticosteroid-treatment-during-the-pre-and-postnatal-periods-affect-the-neurodevelopmental-outcome-of-premature-newborns
#2
Marita Lardón, José Uberos, Eduardo Narbona
INTRODUCTION: Glucocorticoids, widely used in the perinatal period, may be associated with adverse neurodevelopmental effects. OBJECTIVES: To analyze neurodevelopmental outcomes in a cohort of very low birth weight newborns treated with antenatal and/or postnatal corticosteroids. MATERIALS AND METHODS: This was a prospective cohort study in which we included all very low birth weight babies admitted to the neonatal intensive care unit of a tertiary hospital between 2008 and 2013...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28523300/prenatal-glucocorticoid-administration-persistently-increased-the-immunohistochemical-expression-of-type-1-metabotropic-glutamate-receptor-and-purkinje-cell-dendritic-growth-in-the-cerebellar-cortex-of-the-rat
#3
Rodrigo Pascual, Odra Santander, Isabel Cuevas, Martina Valencia
Several studies have indicated that abnormal prenatal changes in the circulating glucocorticoids (GCs), induced by either maternal stress or exogenous GC administration, significantly alter the development of Purkinje cells (PCs). Among the suggested mechanisms that could mediate this GC-dependent PC susceptibility are changes in the expression of type-1 metabotropic glutamate receptors (mGluR1). In the current study, we analyzed whether a single course of prenatally administered betamethasone phosphate (BET) in pregnant rats increased the immunohistochemical expression of mGluR1 in PCs and decreased PC dendritic growth...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521549/efficacy-of-topical-latanoprost-versus-minoxidil-and-betamethasone-valerate-on-the-treatment-of-alopecia-areata
#4
Amal Ahmad El-Ashmawy, Iman Hamed El-Maadawy, Gamal Mohamed El-Maghraby
BACKGROUND: Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA. OBJECTIVE: To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasone valerate on hair growth in patients with AA. PATIENTS AND METHODS: 100 patients with AA classified into 5 groups of 20 treated with: I, latanoprost 0.1% lotion; II, minoxidil 5% lotion; III, betamethasone valerate 0...
May 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28516068/a-comparison-of-betamethasone-valerate-0-1-cream-twice-daily-plus-oral-simvastatin-versus-betamethasone-valerate-0-1-cream-alone-in-the-treatment-of-vitiligo-patients
#5
Fariba Iraji, Seyed Hossin Banihashemi, Gita Faghihi, Zabihollah Shahmoradi, Nabet Tajmirriahi, Safoura Bokaie Jazi
BACKGROUND: Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. This study was conducted to compare the efficacy of topical betamethasone valerate 0.1% cream (as a standard method of treatment for vitiligo) versus a combination of betamethasone valerate plus oral simvastatin in the treatment of vitiligo...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28503212/associations-between-maternal-risk-factors-of-adverse-pregnancy-and-birth-outcomes-and-the-offspring-epigenetic-clock-of-gestational-age-at-birth
#6
Polina Girchenko, Jari Lahti, Darina Czamara, Anna K Knight, Meaghan J Jones, Anna Suarez, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Michael S Kobor, Alicia K Smith, Elisabeth B Binder, Katri Räikkönen
BACKGROUND: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28501545/betamethasone-causes-intergenerational-reproductive-impairment-in-male-rats
#7
Cibele Dos Santos Borges, Taina Louise Pacheco, Katiussia Pinho da Silva, Fábio Henrique Fernandes, Mary Gregory, André Sampaio Pupo, Daisy Maria F Salvadori, Daniel G Cyr, Wilma De G Kempinas
Prenatal betamethasone (BM) exposure in rats negatively impacts sperm quality and male fertility. Studies have shown that BM can cause multi-generational effects on the pituitary-adrenal-axis of rats. The objective of this study was to assess the reproductive development and fertility of male rats (F2) whose fathers (F1) were exposed to BM (0.1mg/kg) on gestational days 12, 13, 18 and 19. In F2 rats, there was a significant reduction in body weights of the BM-treated group at PND 1 as well as delayed onset of puberty, and decreases in FSH levels, Leydig cell volume, sperm number and motility, seminal vesicle contractility and ejaculated volume...
May 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28489468/best-dilution-of-the-best-corticosteroid-for-intralesional-injection-in-the-treatment-of-localized-alopecia-areata-in-adults
#8
Pelin Ustuner, Ali Balevi, Mustafa Özdemir
Purpose To evaluate and compare the clinical efficacy, dermoscopic results and safety of triamcinolone acetonide (TA) and betamethasone dipropionate (BD) injections at different concentrations in localized scalp and beard alopecia. Methods Intralesional injection of BD or TA in three different dilutions; 1/4, 1/8, 1/12 (BD1, BD2, BD3, TA1, TA2, TA3) and Saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients every four weeks in a maximum of 6 sessions until a hair regrowth score of 4 was achieved...
May 10, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28480792/a-rare-presentation-of-meralgia-paraesthetica-in-limb-girdle-muscular-dystrophy
#9
Ozgur Zeliha Karaahmet, Eda Gurcay, Duygu Ozturk, Sukran Guzel, Aytul Cakci
A 44-year-old female with paraesthesia and pain on the left anterolateral thigh who had been diagnosed with limb-girdle muscular dystrophy by electromyography and muscle biopsy is presented. Neurological examination revealed atrophy of the proximal muscles of both shoulders, plus pseudo hypertrophy of both calves. Electromyography exhibited a myopathic pattern. Musculoskeletal ultrasound imaging demonstrated a fusiform nerve swelling below the inguinal ligament suggesting lateral femoral cutaneous nerve compression, consistent with meralgia paraesthetica...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28476075/drugs-for-discoid-lupus-erythematosus
#10
REVIEW
Sue Jessop, David A Whitelaw, Matthew J Grainge, Prativa Jayasekera
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. We wanted to update the review to assess whether any new information was available to treat DLE, as we were still unsure of the effectiveness of available drugs and how to select the most appropriate treatment for an individual with DLE...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28466022/ultrasonography-guided-lumbar-periradicular-injections-for-unilateral-radicular-pain
#11
Qing Wan, Shaoling Wu, Xiao Li, Caina Lin, Songjian Ke, Cuicui Liu, Wenjun Xin, Chao Ma
Objective. The aim of this study was to compare the accuracy and efficacy of sonographically guided lumbar periradicular injections through in-plane or out-of-plane approach techniques for patients with unilateral lower lumbar radicular pain. The feasibility and accuracy of these techniques were studied by means of computed tomography (CT). Methods. A total of 46 patients with chronic unilateral lumbar radicular pain were recruited and randomly assigned to either the in-plane or out-of-plane injection group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28463844/early-delivery-of-sacrococcygeal-teratoma-with-intraspinal-extension
#12
Erin E Perrone, Marcus D Jarboe, Cormac O Maher, Deborah R Berman, Maria Ladino-Torres, Jeannie Kreutzman, Marjorie C Treadwell, George B Mychaliska
Sacrococcygeal teratoma (SCT) with intraspinal extension is rare. There is a risk of paraplegia associated with prolonged spinal cord compression. We present the case of an infant with a prenatal diagnosis of an SCT with a large intraspinal component that was causing compression of the lower spinal cord. Ultrasound at 33 weeks showed bilateral lower extremity and foot movement without hydrops or cardiac failure. Multidisciplinary decision was made to administer betamethasone and proceed with Cesarean delivery at 34 weeks...
May 3, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28463518/acid-sensitive-sheddable-pegylated-mannose-modified-nanoparticles-increase-the-delivery-of-betamethasone-to-chronic-inflammation-sites-in-a-mouse-model
#13
Hannah L O'Mary, Abdulaziz M Aldayel, Solange A Valdes, Youssef W Naguib, Xu Li, Karun Salvady, Zhengrong Cui
Inflammation is implicated in a host of chronic illnesses. Within these inflamed tissues, the pH of the microenvironment is decreased and immune cells, particularly macrophages, infiltrate the area. Additionally, the vascular integrity of these sites is altered with increased fenestrations between endothelial cells. These distinctive properties may be exploited to enhance targeted delivery of anti-inflammatory therapies. Using a mouse model of chronic inflammation, we previously showed that acid-sensitive sheddable PEGylation increases the distribution and retention of nanoparticles in chronic inflammation sites...
May 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28459659/topical-application-of-josamycin-inhibits-development-of-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#14
Katsuhiko Matsui, Kanta Tachioka, Kei Onodera, Reiko Ikeda
BACKGROUND: Patients with atopic dermatitis (AD) have superficial skin colonization by Staphylococcus aureus and an increased number of T helper type 2 (Th2) cells in their peripheral blood. Our previous study showed that josamycin, a macrolide antibiotic, had excellent bactericidal activity against S. aureus strains isolated from AD patients and simultaneously inhibited Th1 and Th2 cell development mediated by Langerhans cells. The purpose of the present study was to evaluate the effect of topical application of josamycin on AD-like skin lesions in NC/Nga mice...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28452226/the-cost-effectiveness-of-blue-light-therapy-in-the-treatment-of-mild-to-moderate-psoriasis
#15
Amir Ansaripour, Hok Bing Thio, Rob Maessen, William Ken Redekop
AIM: To investigate the cost-effectiveness of blue-light therapy versus a two-compound formulation (TCF) (Dovobet(®) gel [calcipotriol and betamethasone]) in mild-to-moderate psoriasis. METHODS: A Markov model was applied to describe the course of disease among Dutch patients with a Psoriasis Area and Severity Index (PASI) score ≤ 10 over a 52-week time horizon. Patients received either 12-week blue-light therapy or two 4-week treatments with TCF. Patients, experiencing no PASI reduction after either therapy, were assumed to receive 12-week ultraviolet B phototherapy...
April 28, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28438780/penetration-route-of-the-selective-glucocorticoid-receptor-agonist-sa22465-and-betamethasone-into-rabbit-meibomian-gland-based-on-pharmacokinetics-and-autoradiography
#16
Nagayoshi Asano, Kenji Ueda, Kouichi Kawazu
Meibomian glands are tiny sebaceous glands embedded within specific types of dense connective tissues. This study investigated drug penetration into meibomian glands following a single topical administration in rabbits. We measured time-course concentrations of the selective glucocorticoid receptor agonist (SEGRA) SA22465 and betamethasone in lid margins, palpebral conjunctival epithelium, and meibomian glands following a single instillation using a newly established collection method. We also visualized the distribution of (14)C-SA22465 in eyelid tissue sections using micro-autoradiography...
April 24, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28432756/high-rate-of-systemic-corticosteroid-prescription-among-outpatient-visits-for-psoriasis-a-population-based-epidemiological-study-using-the-korean-national-health-insurance-database
#17
Sang Jun Eun, Sihyeok Jang, Jin Yong Lee, Young Kyung Do, Seong Jin Jo
The use of systemic corticosteroids (SC) for the treatment of psoriasis is not recommended according to textbooks and guidelines. In clinical practise, however, many physicians frequently prescribe SC for patients with psoriasis. To determine the magnitude of SC prescription for outpatients with psoriasis in Korea and identify factors associated with the use of SC, we used the 2010-2014 nationwide claims data of the Health Insurance Review and Assessment Service of Korea. In frequency analysis for the full scale of prescribed SC, oral methylprednisolone was the most frequently prescribed SC, followed by dexamethasone and betamethasone injections...
April 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28420330/anti-mog-antibody-positive-adem-following-infectious-mononucleosis-due-to-a-primary-ebv-infection-a-case-report
#18
Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima
BACKGROUND: Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. We present a patient who developed anti-MOG antibody-positive ADEM following infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection. CASE PRESENTATION: A 36-year-old healthy man developed paresthesia of bilateral lower extremities and urinary retention 8 days after the onset of IM due to primary EBV infection...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28419600/reformulations-of-well-known-active-ingredients-in-the-topical-treatment-of-psoriasis-vulgaris-can-improve-clinical-outcomes-for-patients
#19
REVIEW
L Iversen, E Dauden, S Segaert, K Freeman, S Magina, D Rigopoulos, D Thaci
BACKGROUND: Although the majority of patients with psoriasis vulgaris are treated exclusively with topical therapies, research to develop more effective topical therapies that are associated with higher patient satisfaction has lagged behind the development of systemic agents. OBJECTIVE: The aim of this literature review was to determine whether there is documented evidence that applying an innovative approach to improving the formulation of active ingredients commonly used in the topical treatment of psoriasis can have a positive effect on clinical outcomes and patient-reported outcomes (PROs)...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28419555/antenatal-betamethasone-for-women-at-risk-for-late-preterm-delivery-reduces-the-rate-of-neonatal-respiratory-complications
#20
Hannah R Canty, Stephanie Dukhovny, Jamie B Warren
No abstract text is available yet for this article.
April 18, 2017: Acta Paediatrica
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