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https://www.readbyqxmd.com/read/28104732/iatrogenic-cushing-s-syndrome-due-to-topical-ocular-glucocorticoid-treatment
#1
Daisuke Fukuhara, Toshihiko Takiura, Hiroshi Keino, Annabelle A Okada, Kunimasa Yan
Iatrogenic Cushing's syndrome (CS) is a severe adverse effect of systemic glucocorticoid (GC) therapy in children, but is extremely rare in the setting of topical ocular GC therapy. In this article, we report the case of a 9-year-old girl suffering from idiopathic uveitis who developed CS due to topical ocular GC treatment. She was referred to the ophthalmology department with a complaint of painful eyes, at which time she was diagnosed with bilateral iridocyclitis and started on a treatment of betamethasone sodium phosphate eye drops...
January 19, 2017: Pediatrics
https://www.readbyqxmd.com/read/28101697/predictors-of-the-usefulness-of-corticosteroids-for-cancer-related-fatigue-in-end-of-life-patients
#2
Yuko Kanbayashi, Toyoshi Hosokawa
BACKGROUND AND OBJECTIVES: Although some studies have examined the use of corticosteroids, their effectiveness in treating cancer-related fatigue (CRF) has yet to be established. Therefore, this retrospective study attempted to identify factors that would predict the usefulness of corticosteroids in treating CRF. METHODS: We examined 87 hospitalized end-of-life cancer patients who were given betamethasone for relief of CRF at our hospital between January 2008 and January 2014...
January 18, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28097506/bioequivalence-methodologies-for-topical-drug-products-in-vitro-and-ex-vivo-studies-with-a-corticosteroid-and-an-anti-fungal-drug
#3
Leila Bastos Leal, Sarah F Cordery, M Begoña Delgado-Charro, Annette L Bunge, Richard H Guy
OBJECTIVE: To examine whether in vitro and ex vivo measurements of topical drug product performance correlate with in vivo outcomes, such that more efficient experimental approaches can be reliably and reproducibly used to establish (in)equivalence between formulations for skin application. MATERIALS AND METHODS: In vitro drug release through artificial membranes, and drug penetration into porcine skin ex vivo, were compared with published human in vivo studies...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28092126/stability-of-a-novel-corticosteroid-nasal-irrigation-solution-betamethasone-17-valerate-added-to-extemporaneously-prepared-nasal-irrigation-solutions
#4
Kheng Yong Ong, Wei Ching Lim, Shing Ming Ooi, Zhi Hui Loh, Ming Chai Kong, Lai Wah Chan, Paul Wan Sia Heng
BACKGROUND: There are no commercially available nasal irrigation solutions containing corticosteroids. Instead, such preparations are extemporaneously prepared by adding existing corticosteroid formulations to nasal irrigation solutions. The stability of the corticosteroid betamethasone 17-valerate (B17V), in nasal irrigation solutions of different compositions and pH and stored under different temperatures, was studied to determine the optimal choice of solution and storage conditions...
January 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28089110/recurrence-after-management-of-meatal-balanitis-xerotica-obliterans
#5
Warren Snodgrass, Juan Soto Blanquel, Nicol Corbin Bush
INTRODUCTION: We review outcomes after management of meatal balanitis xerotica obliterans (BXO). The primary outcome was recurrent meatal BXO. METHODS: A database comprising mostly hypospadias patients was queried for meatal BXO. The disease was confirmed histologically in all cases. Management included topical steroids and/or immunosuppressants, and/or surgical excision of BXO with two-stage oral mucosa graft circumferential replacement urethroplasty. RESULTS: A total of 12 patients had meatal BXO (8 boys and 4 adults)...
November 23, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28069324/differences-in-therapeutic-effects-of-topically-applied-corticosteroid-and-tacrolimus-on-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#6
Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Kyi Chan Ko, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
BACKGROUND: Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. OBJECTIVE: This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms...
December 24, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28054735/initial-study-of-%C3%AE-1-3-galactosyltransferase-gene-knockout-cd46-pig-full-thickness-corneal-xenografts-in-rhesus-monkeys
#7
Xiaojuan Dong, Hidetaka Hara, Ying Wang, Li Wang, Yingnan Zhang, David K C Cooper, Yifan Dai, Zhiqiang Pan
BACKGROUND: To investigate graft survival after full-thickness corneal xenotransplantation from α1,3-galactosyltransferase gene-knockout (GTKO) pigs expressing a human complement regulatory protein (GTKO/CD46 pigs) in rhesus monkeys. METHODS: Rhesus monkeys (n=10) were transplanted with full-thickness corneas from wild-type (WT; n=4) and GTKO/CD46 (n=4) pigs or from monkeys (n=2). All recipient monkeys received post-transplant subconjunctival injections of betamethasone...
January 5, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28052712/the-effects-of-perinatal-steroid-therapy-on-growth-factor-levels-during-different-stages-of-the-developing-brain
#8
Burçin İşcan, Funda Tuzun, Serap Cilaker Micili, Kazim Tugyan, Nuray Duman, Hasan Ozkan, Abdullah Kumral
OBJECTIVE: Excess glucocorticoid exposure on the fetal brain during critical stages of development has considerable effects on the development of the central nervous system. This study thus aimed to evaluate the differential effects of glucocorticoid exposure on critical growth factor levels during different stages of brain maturation. METHODS: For this purpose, forty-two rat pups were divided into six groups based on the timing of betamethasone administration. Rats in the treatment groups were exposed to intraperitoneal betamethasone injections beginning at different time points (postnatal days 1, 2, and 3)...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28035909/comparison-of-the-efficacy-of-lidocaine-and-betamethasone-dipropionate-in-carpal-tunnel-syndrome-injection
#9
Bahar Dernek, Tugba Aydin, Pinar Kursuz Koseoglu, Fatma Nur Kesiktas, Tugba Yesilyurt, Demirhan Diracoglu, Cihan Aksoy
BACKGROUND: Carpal tunnel syndrome (CTS) is a commonly seen peripheral nerve mononeuropathy. Corticosteroid injection within the carpal tunnel is among the conservative treatment options. The exact mechanism of action of steroids is not fully clear; decreased inflammation surrounding nerves or tendons is thought to be the main effect. Lidocaine has been shown to have anti-inflammatory effects on certain cells (monocytes, macrophages, neutrophils etc.). The aim of this study is to evaulate the efficacy of lidocaine treatment as a alternative to corticosteroid treatment in carpal tunnel syndrome...
December 23, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28035387/therapeutic-mechanisms-of-ibuprofen-prednisone-and-betamethasone-in-osteoarthritis
#10
Fenglong Sun, Yaohua Zhang, Qiang Li
The present study aimed to investigate the therapeutic mechanisms of nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids in osteoarthritis (OA). The CHON‑002 human chondrocyte cell line was used in the study. The levels of the cytokines, interleukin (IL)‑1β, IL‑6, IL‑8 and IL‑10, released by cells treated with tumor necrosis factor‑α (TNF‑α) were determined by ELISA. Levels of collagen I, aggrecan, matrix metalloproteinase (MMP)‑1, MMP‑13, signal transducer and activator of transcription (STAT) 3, nuclear factor‑κB (NF‑κB) subunit p65 and inhibitory subunit of NF‑κB (IκB) following treatment with IL‑1β, IL‑6, IL‑8 or IL‑10 were assessed by western blot...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28017774/identification-of-esterase-involved-in-the-metabolism-of-two-corticosteroid-soft-drugs
#11
Ahmed Samir, Nicholas Bodor, Teruko Imai
The soft drug approach is successful in obtaining high local therapeutic efficacy without systemic adverse effects, because soft drugs are designed to be bioconverted to inactive form by hydrolytic enzymes in systemic circulation. However, there is little information about the exact nature of these metabolic enzymes. In this study, the human enzymes for biotransformation of soft drugs were investigated. Loteprednol etabonate (LE) and etiprednol dicloacetate (ED) were designed from Δ(1)-cortienic acid (Δ(1)-CA), the inactive metabolite of prednisolone, by introducing two labile ester bonds to restore the corticosteroidal activity...
December 22, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28017421/steroid-sparing-effect-of-0-1-tacrolimus-eye-drop-for-treatment-of-shield-ulcer-and-corneal-epitheliopathy-in-refractory-allergic-ocular-diseases
#12
Dai Miyazaki, Atsuki Fukushima, Yuichi Ohashi, Nobuyuki Ebihara, Eiichi Uchio, Shigeki Okamoto, Jun Shoji, Etsuko Takamura, Yayoi Nakagawa, Kenichi Namba, Hiroshi Fujishima
PURPOSE: To evaluate the effects of 0.1% topical tacrolimus alone or in combination with steroids for the treatment of shield ulcers and corneal epitheliopathy in patients with refractory allergic ocular diseases. DESIGN: Open cohort study. PARTICIPANTS: Patients with refractory allergic conjunctivitis epitheliopathy, shield ulcers, or corneal plaques (N = 791). METHODS: The 791 patients were treated with topical tacrolimus alone or in combination with topical or oral steroids...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28012189/vitamin-d3-derivatives-alone-or-in-combination-with-glucocorticoids-suppress-streptococcal-pyrogenic-enterotoxin-a-stimulated-proliferation-of-peripheral-blood-mononuclear-cells-in-patients-with-psoriasis
#13
Kae Usui, Yukari Okubo, Toshihiko Hirano, Ryoji Tsuboi
Bacterial colonization on skin or tonsil may influence the clinical response of patients with psoriasis to immunosuppressive drugs. However, few studies have investigated the effects of bacterial superantigens on therapy in these patients. Recently, combination therapy with topical glucocorticoids (GC) and vitamin D3 (VD3) appears to be more effective than GC or VD3 monotherapy for psoriasis. We evaluated the suppressive effects of betamethasone butyrate propionate (BBP), three VD3 derivatives (calcipotriol, maxacalcitol and tacalcitol), cyclosporin and BBP plus VD3, on concanavalin A (ConA)- or streptococcal pyrogenic enterotoxin A (SPEA)-stimulated proliferation of peripheral blood mononuclear cells (PBMC) obtained from 35 psoriasis patients...
December 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/28007901/a-rat-model-of-ataxia-telangiectasia-evidence-for-a-neurodegenerative-phenotype
#14
Hazel Quek, John Luff, KaGeen Cheung, Sergei Kozlov, Magtouf Gatei, C Soon Lee, Mark C Bellingham, Peter G Noakes, Yi Chieh Lim, Nigel L Barnett, Steven Dingwall, Ernst Wolvetang, Tomoji Mashimo, Tara L Roberts, Martin F Lavin
Ataxia-telangiectasia (A-T), an autosomal recessive disease caused by mutations in the ATM gene is characterised by cerebellar atrophy and progressive neurodegeneration which has been poorly recapitulated in Atm mutant mice. Consequently, pathways leading to neurodegeneration in A-T are poorly understood. We describe here the generation of an Atm knockout rat model that does not display cerebellar atrophy but instead paralysis and spinal cord atrophy, reminiscent of that seen in older patients and milder forms of the disorder...
December 22, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27995521/efficacy-and-safety-of-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-compared-with-betamethasone-17-valerate-medicated-plaster-for-the-treatment-of-psoriasis
#15
Catherine Queille-Roussel, Monika Rosen, Fabrice Clonier, Kasper Nørremark, Jean-Philippe Lacour
BACKGROUND: Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam is an alcohol-free treatment for psoriasis. Betamethasone 17-valerate 2.25 mg (BV)-medicated plasters are recommended for treating psoriasis plaques localized in difficult-to-treat (DTT; elbow, knee, anterior face of the tibia) areas. OBJECTIVE: The aim of this study was to compare the efficacy of Cal/BD foam with BV-medicated plaster in patients with plaque psoriasis...
December 19, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27994320/comparative-assessment-of-efficacy-of-two-different-pretreatment-single-oral-doses-of-betamethasone-on-inter-appointment-and-postoperative-discomfort-an-in-vivo-clinical-evaluation
#16
Hitesh Gyanani, Naveen Chhabra, Ghanshyam R Parmar
AIM: Study aimed to evaluate the efficacy of two different pretreatment single oral doses of betamethasone on the incidence of inter-appointment flare up and postoperative discomfort. MATERIALS AND METHODS: Fifty-four patients aged 18-59 years requiring endodontic treatment were selected and randomly assigned to three groups; single pretreatment oral dose of placebo or betamethasone in two different oral doses of 0.5 mg and 1 mg, respectively. Endodontic therapy was completed in two visits using triple antibiotic paste as intracanal medicament...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27982547/back-to-the-future-a-new-topical-approach-for-mild-to-moderate-psoriasis
#17
Giampiero Girolomoni, Piergiacomo Calzavara Pinton, Antonio Cristaudo, Americo Cicchetti
Psoriasis is a chronic-relapsing skin disorder which requires long-term treatments. Therapeutic options for psoriasis include topical treatments, phototherapy and systemic therapy. However, those treatments, and particularly the topical drug therapies, may present some limitations, including poor efficacy/tolerability ratio and lack of adherence. Recently, the supersaturated aerosol foam formulation of the fixed combination calcipotriene plus betamethasone dipropionate (Cal/BD) has gained major attention because it overcomes some of the limitations associated with other topical treatments...
December 16, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27971587/efficacy-of-the-fixed-combination-of-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-vs-traditional-topical-treatment-in-psoriasis-a-bayesian-network-meta-analysis
#18
H Young, G Moncrieff, G Greenall, A H Møller
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970515/the-cost-effectiveness-of-blue-light-therapy-vs-fixed-combination-of-calcipotriol-and-betamethasone-dipropionate-gel-in-the-treatment-of-mild-to-moderate-psoriasis
#19
A Ansaripour, H B Thio, R Maessen, W K Redekop
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27967262/dfd-01-a-novel-topical-formulation-of-betamethasone-dipropionate-for-the-treatment-of-extensive-psoriasis
#20
Paul Yamauchi
Betamethasone dipropionate has been used for the topical treatment of psoriasis in multiple formulations. DFD-01 (Sernivo™, Promius Pharma LLC) is a new midpotent lotion formulation of betamethasone dipropionate 0.05% that has recently been approved for the treatment of mild to moderate psoriasis for up to 4 weeks. Areas covered: This review will critically appraise available clinical information on DFD-01. Phase 3 efficacy and safety results will be reviewed on head-to-head comparison of DFD-01 with a superpotent augmented betamethasone dipropionate 0...
February 2017: Expert Review of Clinical Immunology
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