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https://www.readbyqxmd.com/read/29906695/influence-of-ph-on-the-uptake-and-toxicity-of-%C3%AE-blockers-in-embryos-of-zebrafish-danio-rerio
#1
Lisa Bittner, Elisabet Teixido, Bettina Seiwert, Beate I Escher, Nils Klüver
ß-Blockers are weak bases with acidity constants related to their secondary amine group. At environmental pH they are protonated with the tendency to shift to their neutral species at more alkaline pH. Here we studied the influence of pH from 5.5 to 8.6 on the toxicity of the four ß-blockers atenolol, metoprolol, labetalol and propranolol in zebrafish embryos, relating toxicity not only in a conventional way to external aqueous concentrations but also to measured internal concentrations. Besides lethality, we evaluated changes in swimming activity and heartbeat, using the Locomotor Response (LMR) method and the Vertebrate Automated Screening Technology (VAST) for high throughput imaging...
May 28, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29906652/small-angle-double-quantum-spectroscopy-saqs-nmr
#2
Peyman Sakhaii, Bojan Bohorc, Wolfgang Bermel
A new experiment for recording double quantum spectra is introduced. The 2D DQ NMR experiment yields phase sensitive spectra with double quantum frequencies in F1 . The appearance of remote peaks is vastly suppressed by using a small flip angle double quantum excitation and reconversion. Pulse sequences and phase sensitive processing are discussed. The complexity of the SQ antiphase magnetization given in larger proton spin networks could be reduced by using the option of band selective decoupling during the preparation period...
May 24, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29906563/development-of-phospholipid-nanoparticles-encapsulating-3-o-cetyl-ascorbic-acid-and-tocopherol-acetate-ta-cassome-for-improving-their-skin-accumulation
#3
Tomoka Fushimi, Tomonobu Uchino, Yasunori Miyazaki, Ichiro Hatta, Miyuki Asano, Hiyori Fujino, Rie Suzuki, Shun Fujimori, Daichi Kamiya, Yoshiyuki Kagawa
Phospholipid nanoparticles (PNs) encapsulating vitamin C and E derivatives, 3-O-cetyl ascorbic acid (CA) and tocopherol acetate (TA), respectively, were examined using the film rehydration and extrusion method. PN formulations (TA-Cassome) were prepared by mixing CA, soya phosphatidylcholine (Soya PC), sodium cholate, and TA at a molar ratio of 20/80/5/6. Glycerol (GL) or diglycerol (DG) were also added to improve the skin accumulation of CA and TA. Three TA-Cassome formulations were evaluated using a dynamic light scattering (DLS), NMR, TEM, skin accumulation test for CA and TA, and small-angle X-ray diffraction (SAXD) analysis...
June 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29906284/multi-parametric-quantitative-mri-reveals-three-different-white-matter-subtypes
#4
Jack R Foucher, Olivier Mainberger, Julien Lamy, Mathieu D Santin, Alexandre Vignaud, Mathilde M Roser, Paulo L de Sousa
INTRODUCTION: Magnetic resonance imaging (MRI) shows slight spatial variations in brain white matter (WM). We used quantitative multi-parametric MRI to evaluate in what respect these inhomogeneities could correspond to WM subtypes with specific characteristics and spatial distribution. MATERIALS AND METHODS: Twenty-six controls (12 women, 38 ±9 Y) took part in a 60-min session on a 3T scanner measuring 7 parameters: R1 and R2, diffusion tensor imaging which allowed to measure Axial and Radial Diffusivity (AD, RD), magnetization transfer imaging which enabled to compute the Macromolecular Proton Fraction (MPF), and a susceptibility-weighted sequence which permitted to quantify R2* and magnetic susceptibility (χm)...
2018: PloS One
https://www.readbyqxmd.com/read/29906166/search-for-heavy-neutral-leptons-in-events-with-three-charged-leptons-in-proton-proton-collisions-at-sqrt-s-13-tev
#5
A M Sirunyan, A Tumasyan, W Adam, F Ambrogi, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, A Escalante Del Valle, M Flechl, M Friedl, R Frühwirth, V M Ghete, J Grossmann, J Hrubec, M Jeitler, A König, N Krammer, I Krätschmer, D Liko, T Madlener, I Mikulec, E Pree, N Rad, H Rohringer, J Schieck, R Schöfbeck, M Spanring, D Spitzbart, A Taurok, W Waltenberger, J Wittmann, C-E Wulz, M Zarucki, V Chekhovsky, V Mossolov, J Suarez Gonzalez, E A De Wolf, D Di Croce, X Janssen, J Lauwers, M Pieters, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, S Abu Zeid, F Blekman, J D'Hondt, I De Bruyn, J De Clercq, K Deroover, G Flouris, D Lontkovskyi, S Lowette, I Marchesini, S Moortgat, L Moreels, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, D Beghin, B Bilin, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, B Dorney, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, A K Kalsi, T Lenzi, J Luetic, T Maerschalk, T Seva, E Starling, C Vander Velde, P Vanlaer, D Vannerom, R Yonamine, F Zenoni, T Cornelis, D Dobur, A Fagot, M Gul, I Khvastunov, D Poyraz, C Roskas, D Trocino, M Tytgat, W Verbeke, M Vit, N Zaganidis, H Bakhshiansohi, O Bondu, S Brochet, G Bruno, C Caputo, A Caudron, P David, S De Visscher, C Delaere, M Delcourt, B Francois, A Giammanco, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, K Piotrzkowski, L Quertenmont, A Saggio, M Vidal Marono, S Wertz, J Zobec, W L Aldá Júnior, F L Alves, G A Alves, L Brito, G Correia Silva, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, E Coelho, E M Da Costa, G G Da Silveira, D De Jesus Damiao, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, M Melo De Almeida, C Mora Herrera, L Mundim, H Nogima, L J Sanchez Rosas, A Santoro, A Sznajder, M Thiel, E J Tonelli Manganote, F Torres Da Silva De Araujo, A Vilela Pereira, S Ahuja, C A Bernardes, T R Fernandez Perez Tomei, E M Gregores, P G 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Raidal, C Veelken, P Eerola, H Kirschenmann, J Pekkanen, M Voutilainen, J Havukainen, J K Heikkilä, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Laurila, S Lehti, T Lindén, P Luukka, T Mäenpää, H Siikonen, E Tuominen, J Tuominiemi, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, J L Faure, F Ferri, S Ganjour, S Ghosh, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, C Leloup, E Locci, M Machet, J Malcles, G Negro, J Rander, A Rosowsky, M Ö Sahin, M Titov, A Abdulsalam, C Amendola, I Antropov, S Baffioni, F Beaudette, P Busson, L Cadamuro, C Charlot, R Granier de Cassagnac, M Jo, I Kucher, S Lisniak, A Lobanov, J Martin Blanco, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, R Salerno, J B Sauvan, Y Sirois, A G Stahl Leiton, Y Yilmaz, A Zabi, A Zghiche, J-L Agram, J Andrea, D Bloch, J-M Brom, M Buttignol, E C Chabert, C Collard, E Conte, X Coubez, F Drouhin, J-C Fontaine, D Gelé, U Goerlach, M Jansová, P Juillot, A-C Le Bihan, N Tonon, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, N Chanon, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fay, L Finco, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, H Lattaud, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, V Sordini, M Vander Donckt, S Viret, S Zhang, T Toriashvili, Z Tsamalaidze, C Autermann, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, C Schomakers, J Schulz, M Teroerde, B Wittmer, V Zhukov, A Albert, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, A Güth, T Hebbeker, C Heidemann, K Hoepfner, S Knutzen, M Merschmeyer, A Meyer, P Millet, S Mukherjee, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, D Teyssier, S Thüer, G Flügge, B Kargoll, T Kress, A Künsken, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, K Beernaert, O Behnke, U Behrens, A Bermúdez Martínez, A A Bin Anuar, K Borras, V Botta, A Campbell, P Connor, C Contreras-Campana, F Costanza, A De Wit, C Diez Pardos, G Eckerlin, D Eckstein, T Eichhorn, E Eren, E Gallo, J Garay Garcia, A Geiser, J M Grados Luyando, A Grohsjean, P Gunnellini, M Guthoff, A Harb, J Hauk, M Hempel, H Jung, M Kasemann, J Keaveney, C Kleinwort, I Korol, D Krücker, W Lange, A Lelek, T Lenz, K Lipka, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, M Meyer, M Missiroli, G Mittag, J Mnich, A Mussgiller, D Pitzl, A Raspereza, M Savitskyi, P Saxena, R Shevchenko, N Stefaniuk, H Tholen, G P Van Onsem, R Walsh, Y Wen, K Wichmann, C Wissing, O Zenaiev, R Aggleton, S Bein, V Blobel, M Centis Vignali, T Dreyer, E Garutti, D Gonzalez, J Haller, A Hinzmann, M Hoffmann, A Karavdina, G Kasieczka, R Klanner, R Kogler, N Kovalchuk, S Kurz, D Marconi, J Multhaup, M Niedziela, D Nowatschin, T Peiffer, A Perieanu, A Reimers, C Scharf, P Schleper, A Schmidt, S Schumann, J Schwandt, J Sonneveld, H Stadie, G Steinbrück, F M Stober, M Stöver, D Troendle, E Usai, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, M Baselga, S Baur, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, N Faltermann, B Freund, R Friese, M Giffels, M A Harrendorf, F Hartmann, S M Heindl, U Husemann, F Kassel, S Kudella, H Mildner, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, A Kyriakis, D Loukas, I Topsis-Giotis, G Karathanasis, S Kesisoglou, A Panagiotou, N Saoulidou, E Tziaferi, K Kousouris, I Papakrivopoulos, I Evangelou, C Foudas, P Gianneios, P Katsoulis, P Kokkas, S Mallios, N Manthos, I Papadopoulos, E Paradas, J Strologas, F A Triantis, D Tsitsonis, M Csanad, N Filipovic, G Pasztor, O Surányi, G I Veres, G Bencze, C Hajdu, D Horvath, Á Hunyadi, F Sikler, V Veszpremi, G Vesztergombi, T Á Vámi, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, M Bartók, P Raics, Z L Trocsanyi, B Ujvari, S Choudhury, J R Komaragiri, S Bahinipati, P Mal, K Mandal, A Nayak, D K Sahoo, N Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, R Chawla, N Dhingra, R Gupta, A Kaur, M Kaur, S Kaur, R Kumar, P Kumari, A Mehta, S Sharma, J B Singh, G Walia, Ashok Kumar, Aashaq Shah, A Bhardwaj, S Chauhan, B C Choudhary, R B Garg, S Keshri, A Kumar, S Malhotra, M Naimuddin, K Ranjan, R Sharma, R Bhardwaj, R Bhattacharya, S Bhattacharya, U Bhawandeep, D Bhowmik, S Dey, S Dutt, S Dutta, S Ghosh, N Majumdar, A Modak, K Mondal, S Mukhopadhyay, S Nandan, A Purohit, P K Rout, A Roy, S Roy Chowdhury, S Sarkar, M Sharan, B Singh, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, A K Mohanty, P K Netrakanti, L M Pant, P Shukla, A Topkar, T Aziz, S Dugad, B Mahakud, S Mitra, G B Mohanty, N Sur, B Sutar, S Banerjee, S Bhattacharya, S Chatterjee, P Das, M Guchait, Sa Jain, S Kumar, M Maity, G Majumder, K Mazumdar, T Sarkar, N Wickramage, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, A Di Florio, F Errico, L Fiore, G Iaselli, S Lezki, G Maggi, M Maggi, B Marangelli, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Zito, G Abbiendi, C Battilana, D Bonacorsi, L Borgonovi, S Braibant-Giacomelli, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, F Iemmi, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, A M Rossi, T Rovelli, G P Siroli, N Tosi, S Albergo, S Costa, A Di Mattia, F Giordano, R Potenza, A Tricomi, C Tuve, G Barbagli, K Chatterjee, V Ciulli, C Civinini, R D'Alessandro, E Focardi, G Latino, P Lenzi, M Meschini, S Paoletti, L Russo, G Sguazzoni, D Strom, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Primavera, V Calvelli, F Ferro, F Ravera, E Robutti, S Tosi, A Benaglia, A Beschi, L Brianza, F Brivio, V Ciriolo, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, R A Manzoni, D Menasce, L Moroni, M Paganoni, K Pauwels, D Pedrini, S Pigazzini, S Ragazzi, T Tabarelli de Fatis, S Buontempo, N Cavallo, S Di Guida, F Fabozzi, F Fienga, A O M Iorio, W A Khan, L Lista, S Meola, P Paolucci, C Sciacca, F Thyssen, P Azzi, N Bacchetta, L Benato, D Bisello, A Boletti, R Carlin, P Checchia, M Dall'Osso, P De Castro Manzano, T Dorigo, U Dosselli, F Gasparini, U Gasparini, A Gozzelino, S Lacaprara, P Lujan, M Margoni, A T Meneguzzo, N Pozzobon, P Ronchese, R Rossin, F Simonetto, A Tiko, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, M Ressegotti, C Riccardi, P Salvini, I Vai, P Vitulo, L Alunni Solestizi, M Biasini, G M Bilei, C Cecchi, D Ciangottini, L Fanò, P Lariccia, R Leonardi, E Manoni, G Mantovani, V Mariani, M Menichelli, A Rossi, A Santocchia, D Spiga, K Androsov, P Azzurri, G Bagliesi, L Bianchini, T Boccali, L Borrello, R Castaldi, M A Ciocci, R Dell'Orso, G Fedi, L Giannini, A Giassi, M T Grippo, F Ligabue, T Lomtadze, E Manca, G Mandorli, A Messineo, F Palla, A Rizzi, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, N Daci, D Del Re, E Di Marco, M Diemoz, S Gelli, E Longo, F Margaroli, B Marzocchi, P Meridiani, G Organtini, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, R Castello, F Cenna, M Costa, R Covarelli, A Degano, N Demaria, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, A Staiano, P Traczyk, S Belforte, M Casarsa, F Cossutti, G Della Ricca, A Zanetti, D H Kim, G N Kim, M S Kim, J Lee, S Lee, S W Lee, C S Moon, Y D Oh, S Sekmen, D C Son, Y C Yang, H Kim, D H Moon, G Oh, J A Brochero Cifuentes, J Goh, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, Y Kim, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, J Almond, J Kim, J S Kim, H Lee, K Lee, K Nam, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, H Kim, J H Kim, J S H Lee, I C Park, Y Choi, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, R Reyes-Almanza, G Ramirez-Sanchez, M C Duran-Osuna, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, R I Rabadan-Trejo, R Lopez-Fernandez, J Mejia Guisao, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, J Eysermans, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, P H Butler, A Ahmad, M Ahmad, Q Hassan, H R Hoorani, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, M Szleper, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, A Pyskir, M Walczak, P Bargassa, C Beirão Da Cruz E Silva, A Di Francesco, P Faccioli, B Galinhas, M Gallinaro, J Hollar, N Leonardo, L Lloret Iglesias, M V Nemallapudi, J Seixas, G Strong, O Toldaiev, D Vadruccio, J Varela, S Afanasiev, P Bunin, M Gavrilenko, I Golutvin, I Gorbunov, A Kamenev, V Karjavin, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, S Shmatov, S Shulha, N Skatchkov, V Smirnov, N Voytishin, A Zarubin, Y Ivanov, V Kim, E Kuznetsova, P Levchenko, V Murzin, V Oreshkin, I Smirnov, D Sosnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V 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J Puerta Pelayo, I Redondo, L Romero, M S Soares, A Triossi, A Álvarez Fernández, C Albajar, J F de Trocóniz, J Cuevas, C Erice, J Fernandez Menendez, S Folgueras, I Gonzalez Caballero, J R González Fernández, E Palencia Cortezon, S Sanchez Cruz, P Vischia, J M Vizan Garcia, I J Cabrillo, A Calderon, B Chazin Quero, J Duarte Campderros, M Fernandez, P J Fernández Manteca, J Garcia-Ferrero, A García Alonso, G Gomez, A Lopez Virto, J Marco, C Martinez Rivero, P Martinez Ruiz Del Arbol, F Matorras, J Piedra Gomez, C Prieels, T Rodrigo, A Ruiz-Jimeno, L Scodellaro, N Trevisani, I Vila, R Vilar Cortabitarte, D Abbaneo, B Akgun, E Auffray, P Baillon, A H Ball, D Barney, J Bendavid, M Bianco, A Bocci, C Botta, T Camporesi, M Cepeda, G Cerminara, E Chapon, Y Chen, D d'Enterria, A Dabrowski, V Daponte, A David, M De Gruttola, A De Roeck, N Deelen, M Dobson, T du Pree, M Dünser, N Dupont, A Elliott-Peisert, P Everaerts, F Fallavollita, G Franzoni, J Fulcher, W Funk, D Gigi, A Gilbert, K Gill, F Glege, D Gulhan, J Hegeman, V Innocente, A Jafari, P Janot, O Karacheban, J Kieseler, V Knünz, A Kornmayer, M J Kortelainen, M Krammer, C Lange, P Lecoq, C Lourenço, M T Lucchini, L Malgeri, M Mannelli, A Martelli, F Meijers, J A Merlin, S Mersi, E Meschi, P Milenovic, F Moortgat, M Mulders, H Neugebauer, J Ngadiuba, S Orfanelli, L Orsini, F Pantaleo, L Pape, E Perez, M Peruzzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, F M Pitters, D Rabady, A Racz, T Reis, G Rolandi, M Rovere, H Sakulin, C Schäfer, C Schwick, M Seidel, M Selvaggi, A Sharma, P Silva, P Sphicas, A Stakia, J Steggemann, M Stoye, M Tosi, D Treille, A Tsirou, V Veckalns, M Verweij, W D Zeuner, W Bertl, L Caminada, K Deiters, W Erdmann, R Horisberger, Q Ingram, H C Kaestli, D Kotlinski, U Langenegger, T Rohe, S A Wiederkehr, M Backhaus, L Bäni, P Berger, B Casal, G Dissertori, M Dittmar, M Donegà, C Dorfer, C Grab, C Heidegger, D Hits, J Hoss, T Klijnsma, W Lustermann, M Marionneau, M T Meinhard, D Meister, F Micheli, P Musella, F Nessi-Tedaldi, F Pandolfi, J Pata, F Pauss, G Perrin, L Perrozzi, M Quittnat, M Reichmann, D A Sanz Becerra, M Schönenberger, L Shchutska, V R Tavolaro, K Theofilatos, M L Vesterbacka Olsson, R Wallny, D H Zhu, T K Aarrestad, C Amsler, D Brzhechko, M F Canelli, A De Cosa, R Del Burgo, S Donato, C Galloni, T Hreus, B Kilminster, I Neutelings, D Pinna, G Rauco, P Robmann, D Salerno, K Schweiger, C Seitz, Y Takahashi, A Zucchetta, V Candelise, Y H Chang, K Y Cheng, T H Doan, Sh Jain, R Khurana, C M Kuo, W Lin, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y Chao, K F Chen, P H Chen, F Fiori, W-S Hou, Y Hsiung, Y F Liu, R-S Lu, E Paganis, A Psallidas, A Steen, J F Tsai, B Asavapibhop, K Kovitanggoon, G Singh, N Srimanobhas, M N Bakirci, A Bat, F Boran, S Damarseckin, Z S Demiroglu, C Dozen, E Eskut, S Girgis, G Gokbulut, Y Guler, I Hos, E E Kangal, O Kara, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, S Ozturk, A Polatoz, D Sunar Cerci, U G Tok, S Turkcapar, I S Zorbakir, C Zorbilmez, G Karapinar, K Ocalan, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, S Tekten, E A Yetkin, M N Agaras, S Atay, A Cakir, K Cankocak, Y Komurcu, B Grynyov, L Levchuk, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, O Davignon, H Flacher, J Goldstein, G P Heath, H F Heath, L Kreczko, D M Newbold, S Paramesvaran, T Sakuma, S Seif El Nasr-Storey, D Smith, V J Smith, K W Bell, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Linacre, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, W J Womersley, G Auzinger, R Bainbridge, P Bloch, J Borg, S Breeze, O Buchmuller, A Bundock, S Casasso, D Colling, L Corpe, P Dauncey, G Davies, M Della Negra, R Di Maria, Y Haddad, G Hall, G Iles, T James, M Komm, R Lane, C Laner, L Lyons, A-M Magnan, S Malik, L Mastrolorenzo, T Matsushita, J Nash, A Nikitenko, V Palladino, M Pesaresi, A Richards, A Rose, E Scott, C Seez, A Shtipliyski, T Strebler, S Summers, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, N Wardle, D Winterbottom, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, A Morton, I D Reid, L Teodorescu, S Zahid, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, C Smith, R Bartek, A Dominguez, A Buccilli, S I Cooper, C Henderson, P Rumerio, C West, D Arcaro, A Avetisyan, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, D Cutts, M Hadley, J Hakala, U Heintz, J M Hogan, K H M Kwok, E Laird, G Landsberg, J Lee, Z Mao, M Narain, J Pazzini, S Piperov, S Sagir, R Syarif, D Yu, R Band, C Brainerd, R Breedon, D Burns, M Calderon De La Barca Sanchez, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, S Shalhout, M Shi, J Smith, D Stolp, D Taylor, K Tos, M Tripathi, Z Wang, F Zhang, M Bachtis, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, S Regnard, D Saltzberg, C Schnaible, V Valuev, E Bouvier, K Burt, R Clare, J Ellison, J W Gary, S M A Ghiasi Shirazi, G Hanson, G Karapostoli, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, W Si, L Wang, H Wei, S Wimpenny, B R Yates, J G Branson, S Cittolin, M Derdzinski, R Gerosa, D Gilbert, B Hashemi, A Holzner, D Klein, G Kole, V Krutelyov, J Letts, M Masciovecchio, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, M Citron, A Dishaw, V Dutta, M Franco Sevilla, L Gouskos, R Heller, J Incandela, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, J Yoo, D Anderson, A Bornheim, J Bunn, J M Lawhorn, H B Newman, T Q Nguyen, C Pena, M Spiropulu, J R Vlimant, R Wilkinson, S Xie, Z Zhang, R Y Zhu, M B Andrews, T Ferguson, T Mudholkar, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, S Leontsinis, E Macdonald, T Mulholland, K Stenson, K A Ulmer, S R Wagner, J Alexander, J Chaves, Y Cheng, J Chu, A Datta, S Dittmer, K Mcdermott, N Mirman, J R Patterson, D Quach, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, S Abdullin, M Albrow, M Alyari, G Apollinari, A Apresyan, A Apyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, A Canepa, G B Cerati, H W K Cheung, F Chlebana, M Cremonesi, J Duarte, V D Elvira, J Freeman, Z Gecse, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, J Hanlon, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, D Lincoln, R Lipton, M Liu, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, A Savoy-Navarro, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, W Wu, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, R D Field, I K Furic, S V Gleyzer, B M Joshi, J Konigsberg, A Korytov, K Kotov, P Ma, K Matchev, H Mei, G Mitselmakher, K Shi, D Sperka, N Terentyev, L Thomas, J Wang, S Wang, J Yelton, Y R Joshi, S Linn, P Markowitz, J L Rodriguez, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, A Santra, V Sharma, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, I D Sandoval Gonzalez, M B Tonjes, N Varelas, H Wang, Z Wu, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Rogan, C Royon, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, F Rebassoo, D Wright, A Baden, O Baron, A Belloni, S C Eno, Y Feng, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, D Abercrombie, B Allen, V Azzolini, R Barbieri, A Baty, G Bauer, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, P Harris, D Hsu, M Hu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y-J Lee, A Levin, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Sumorok, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, S Zhaozhong, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, S Kalafut, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, J Turkewitz, M A Wadud, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, F Golf, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, J Dolen, A Godshalk, C Harrington, I Iashvili, D Nguyen, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, C Freer, A Hortiangtham, A Massironi, D M Morse, T Orimoto, R Teixeira De Lima, T Wamorkar, B Wang, A Wisecarver, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, M H Schmitt, K Sung, M Trovato, M Velasco, R Bucci, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, W Li, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, P Siddireddy, G Smith, S Taroni, M Wayne, A Wightman, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, T Y Ling, W Luo, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, S Higginbotham, A Kalogeropoulos, D Lange, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, S Das, L Gutay, M Jones, A W Jung, A Khatiwada, D H Miller, N Neumeister, C C Peng, H Qiu, J F Schulte, J Sun, F Wang, R Xiao, W Xie, T Cheng, N Parashar, Z Chen, K M Ecklund, S Freed, F J M Geurts, M Guilbaud, M Kilpatrick, W Li, B Michlin, B P Padley, J Roberts, J Rorie, W Shi, Z Tu, J Zabel, A Zhang, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, R Ciesielski, K Goulianos, C Mesropian, A Agapitos, J P Chou, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Castaneda Hernandez, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Safonov, A Tatarinov, N Akchurin, J Damgov, F De Guio, P R Dudero, J Faulkner, E Gurpinar, S Kunori, K Lamichhane, S W Lee, T Mengke, S Muthumuni, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, N Poudyal, J Sturdy, P Thapa, S Zaleski, M Brodski, J Buchanan, C Caillol, D Carlsmith, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, V Rekovic, T Ruggles, A Savin, N Smith, W H Smith, N Woods
A search for a heavy neutral lepton N of Majorana nature decaying into a W boson and a charged lepton is performed using the CMS detector at the LHC. The targeted signature consists of three prompt charged leptons in any flavor combination of electrons and muons. The data were collected in proton-proton collisions at a center-of-mass energy of 13 TeV, with an integrated luminosity of 35.9  fb^{-1}. The search is performed in the N mass range between 1 GeV and 1.2 TeV. The data are found to be consistent with the expected standard model background...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29906163/probing-long-range-neutrino-mediated-forces-with-atomic-and-nuclear-spectroscopy
#6
Yevgeny V Stadnik
The exchange of a pair of low-mass neutrinos between electrons, protons, and neutrons produces a "long-range" 1/r^{5} potential, which can be sought for in phenomena originating on the atomic and subatomic length scales. We calculate the effects of neutrino-pair exchange on transition and binding energies in atoms and nuclei. In the case of atomic s-wave states, there is a large enhancement of the induced energy shifts due to the lack of a centrifugal barrier and the highly singular nature of the neutrino-mediated potential...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29906144/hydrogen-diffusion-and-trapping-in-%C3%AE-iron-the-role-of-quantum-and-anharmonic-fluctuations
#7
Bingqing Cheng, Anthony T Paxton, Michele Ceriotti
We investigate the thermodynamics and kinetics of a hydrogen interstitial in magnetic α-iron, taking account of the quantum fluctuations of the proton as well as the anharmonicities of lattice vibrations and hydrogen hopping. We show that the diffusivity of hydrogen in the lattice of bcc iron deviates strongly from an Arrhenius behavior at and below room temperature. We compare a quantum transition state theory to explicit ring polymer molecular dynamics in the calculation of diffusivity. We then address the trapping of hydrogen by a vacancy as a prototype lattice defect...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29906102/unraveling-the-detailed-mechanism-of-excited-state-proton-transfer
#8
Panwang Zhou, Keli Han
As one of the most fundamental processes, excited-state proton transfer (ESPT) plays a major role in both chemical and biological systems. In the past several decades, experimental and theoretical studies on ESPT systems have attracted considerable attention because of their tremendous potential in fluorescent probes, biological imaging, white-light-emitting materials, and organic optoelectronic materials. ESPT is related to fluorescence properties and usually occurs on an ultrafast time scale at or below 100 fs...
June 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29905983/understanding-the-rate-limiting-step-of-glycogenolysis-using-qm-mm-calculations-on-the-human-glycogen-phosphorylase
#9
Natercia Bras, Pedro Fernandes, Maria João Ramos
Liver's glycogen phosphorylase (GP) is a key enzyme to human health, as its increased activity is associated with type 2 diabetes. The GP catalytic mechanism has been explored by quantum mechanics/molecular mechanics methods. Herein, we propose a mechanism that proceeds via three steps: i) it begins with a H transfer from the phosphate group of the pyridoxal 5'-phosphate (HPO42--PLP) cofactor to the phosphate substrate; ii) then, the glycosidic linkage is cleaved through protonation of the glycosidic oxygen atom by an hydroxyl of the inorganic phosphate group; and iii) an oxygen atom of the phosphate performs a nucleophilic attack on the anomeric carbon of glucose, concomitantly with the return of a proton from phosphate to PO43--PLP, which finally leads to the formation of the glucose-1-phosphate product and recovers the initial state of the PLP cofactor...
June 15, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29905959/design-considerations-for-a-pulse-line-ion-accelerator-plia-based-pet-isotope-generator
#10
David C Westerly, Reza A Behbahani, Brian Kavanagh, Arthur Liu, Moyed Miften, Natalie J Serkova, Quentin Diot
PURPOSE: Positron emission tomography (PET) imaging remains limited by the cost associated with on-site production of short half-life, positron emitting isotopes. In this work, we examine the use of a pulse line ion accelerator (PLIA) to accelerate protons for single-dose PET isotope production. METHODS: Time-domain electromagnetic field and particle-in-cell (PIC) simulations were performed for a 1.5 m PLIA structure modeled in CST Microwave Studio and Particle Studio software...
June 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29905948/migration-of-water-in-litopenaeus-vannamei-muscle-following-freezing-and-thawing
#11
Qi Deng, Yaling Wang, Lijun Sun, Jianrong Li, Zhijia Fang, Ravi Gooneratne
Water and protein are major constituents of shrimp, any changes in protein and the state of water influence the quality of shrimp. Therefore, a study to examine the law of moisture migration and protein denaturation under different freezing and thawing conditions is important. The proton density images of thawed frozen-shrimp revealed that the water loss during quick-freezing was much greater than that during slow freezing or microfreezing. At room temperature (25 °C), the water loss from brine-thawing was more than still-water thawing and still-water thawing was more than thawing spontaneously...
June 15, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29905942/quality-of-life-in-patients-with-proton-treated-pediatric-medulloblastoma-results-of-a-prospective-assessment-with-5-year-follow-up
#12
Sophia C Kamran, Saveli I Goldberg, Karen A Kuhlthau, Miranda P Lawell, Elizabeth A Weyman, Sara L Gallotto, Clayton B Hess, Mary S Huang, Alison M Friedmann, Annah N Abrams, Shannon M MacDonald, Margaret B Pulsifer, Nancy J Tarbell, David H Ebb, Torunn I Yock
BACKGROUND: To the authors' knowledge, health-related quality of life (HRQOL) outcomes are not well described in patients with medulloblastoma. The use of proton radiotherapy (RT) may translate into an improved HRQOL. In the current study, the authors report long-term HRQOL in patients with proton-treated pediatric medulloblastoma. METHODS: The current study was a prospective cohort HRQOL study of patients with medulloblastoma who were treated with proton RT and enrolled between August 5, 2002, and October 8, 2015...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905070/%C3%AE-chlorobenzylation-of-nitroarenes-via-vicarious-nucleophilic-substitution-with-benzylidene-dichloride-umpolung-of-the-friedel-crafts-reaction
#13
Jakub Brześkiewicz, Rafał Loska, Mieczyslaw Makosza
Readily available α,α-dichlorotoluenes enter a vicarious nucleophilic substitution (VNS) reaction with electron-deficient arenes to give α-chlorobenzylated nitrobenzenes, as well as six- and five-membered heterocycles. Oxidation of the initially formed α-chlorobenzylic carbanions instead of protonation results in formation of bis(aryl) ketones, providing a means of overall nucleophilic C-H-benzoylation of electron-deficient aromatic rings. Alternatively, benzoylated nitroarenes can be obtained via the reaction of isolated α-chlorodiarylmethanes with sodium azide...
June 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29904993/early-cell-death-induced-by-clostridium-difficile-tcdb-uptake-and-rac1-glucosylation-kinetics-are-decisive-for-cell-fate
#14
Lara-Antonia Beer, Helma Tatge, Nicole Reich, Michel Tenspolde, Alexandra Olling, Sebastian Goy, Klemens Rottner, Alexi Kirilov Alekov, Ralf Gerhard
Toxin A and Toxin B (TcdA/TcdB) are large glucosyltransferases produced by Clostridium difficile. TcdB but not TcdA induces reactive oxygen species (ROS)-mediated early cell death when applied at high concentrations. We found that non-glucosylated Rac1 is essential for induction of early cell death since inhibition of Rac1 impedes this effect. Early cell death only occurs when TcdB is rapidly endocytosed. This was shown by generation of chimeras using the trunk of TcdB from a hypervirulent strain. TcdB from hypervirulent strain has been described to translocate from endosomes at higher pH values and thus, meaning faster than reference type TcdB...
June 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29904766/protonation-state-and-fine-structure-of-the-active-site-determine-the-reactivity-of-dehydratase-hydration-and-isomerization-of-%C3%AE-myrcene-catalyzed-by-linalool-dehydratase-isomerase-from-castellaniella-defragrans
#15
Baoping Ling, Xiya Wang, Hao Su, Rutao Liu, Yongjun Liu
Linalool dehydratase/isomerase (LinD) from Castellaniella defragrans is a bifunctional enzyme that catalyzes the hydration of β-myrcene to (S)-linalool and the isomerization of (S)-linalool to geraniol. In this paper, on the basis of recently obtained crystal structures, the catalytic mechanism of LinD has been explored by a combined quantum mechanics and molecular mechanics (QM/MM) approach. Two computational models have been constructed. Model I (LinD-linalool) was derived from the crystal structure of the selenomethionine derivative of LinD (Semet-LinD) in complex with the natural substrate geraniol, whereas model II (LinD-β-myrcene) was constructed from the crystal structure of LinD in complex with β-myrcene...
June 15, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29904244/treatment-of-helicobacter-pylori-infection-in-atrophic-gastritis
#16
REVIEW
Edith Lahner, Marilia Carabotti, Bruno Annibale
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis (AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29903883/retinal-isomerization-in-bacteriorhodopsin-captured-by-a-femtosecond-x-ray-laser
#17
Przemyslaw Nogly, Tobias Weinert, Daniel James, Sergio Carbajo, Dmitry Ozerov, Antonia Furrer, Dardan Gashi, Veniamin Borin, Petr Skopintsev, Kathrin Jaeger, Karol Nass, Petra Båth, Robert Bosman, Jason Koglin, Matthew Seaberg, Thomas Lane, Demet Kekilli, Steffen Brünle, Tomoyuki Tanaka, Wenting Wu, Christopher Milne, Thomas White, Anton Barty, Uwe Weierstall, Valerie Panneels, Eriko Nango, So Iwata, Mark Hunter, Igor Schapiro, Gebhard Schertler, Richard Neutze, Jörg Standfuss
Ultrafast isomerization of retinal is the primary step in photoresponsive biological functions including vision in humans and ion-transport across bacterial membranes. We studied the sub-picosecond structural dynamics of retinal isomerization in the light-driven proton pump bacteriorhodopsin using an x-ray laser. A series of structural snapshots with near-atomic spatial and temporal resolution in the femtosecond regime show how the excited all- trans retinal samples conformational states within the protein binding pocket prior to passing through a twisted geometry and emerging in the 13 -cis conformation...
June 14, 2018: Science
https://www.readbyqxmd.com/read/29902770/spectroscopic-methods-for-the-study-of-energetic-characteristics-of-the-normal-and-photoproduct-forms-of-3-hydroxyflavones
#18
Dzmitryi V Ushakou, Vladimir I Tomin
We report spectroscopic properties of 3-hydroxyflavone (3-HF) and 4'-N,N-dimethylamino-3-hydroxyflavone (DMA3HF) in acetonitrile and ethyl acetate at different temperatures in the range from 10 °C to about 67 °C. These compounds are characterized by excited-state intramolecular proton transfer (ESIPT) which leads to occurrence of two forms of these molecules. For this reason their fluorescence spectra have two bands which correspond to emission of normal and photoproduct (tautomer) forms. The correlation between ratio of integrated intensity of these two bands and inverse absolute temperature (the Arrhenius plot) have been applied to estimate energetic properties, such as difference between energy levels of excited states as well ground states for normal and tautomer forms for each molecule...
June 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29902633/proton-elisa-electrochemical-immunoassay-on-a-dual-gated-isfet-array
#19
Duane S Juang, Ching-Hui Lin, Yi-Ren Huo, Chia-Yu Tang, Chun-Ren Cheng, Hua-Shu Wu, Shih-Fen Huang, Alexander Kalnitsky, Chun-Cheng Lin
Here we report an electrochemical immunoassay platform called Proton-ELISA (H-ELISA) for the detection of bioanalytes. H-ELISA uniquely utilizes protons as an immunoassay detection medium, generated by the enzyme glucose oxidase (GOx) coupled with Fenton's reagent in a proton amplification reaction cascade that results in a highly amplified signal. A proton-sensitive dual-gated ion-sensitive field effect transistor (DG-ISFET) sensor was also developed for sensitive and accurate detection of the proton signal in H-ELISA...
June 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29902507/ph-responsive-hyaluronated-liposomes-for-docetaxel-delivery
#20
Jae Min Lee, Hongsuk Park, Kyung Taek Oh, Eun Seong Lee
In this study, we report pH-responsive liposomes consisting of hydrogenated soy phosphatidylcholine (HSPC) as a lipid, hyaluronic acid (HA) grafted with functional 3-diethylaminopropyl (DEAP) groups (hereafter denoted as HA-g-DEAP) as a pH-responsive polymer, and docetaxel (DTX) as an antitumor drug. DTX-loaded HSPC liposomes were prepared via a conventional liposome manufacturing procedure and then were decorated with HA-g-DEAP (HA-g-DEAP0.15 , HA-g-DEAP0.25 , and HA-g-DEAP0.40 , according to the molar conjugate ratio of DEAP to HA) in an aqueous solution (pH 7...
June 11, 2018: International Journal of Pharmaceutics
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