keyword
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#1
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536908/tisb-protein-is-the-single-molecular-determinant-underlying-multiple-downstream-effects-of-ofloxacin-in-escherichia-coli
#2
JOURNAL ARTICLE
Julien Cayron, Thierry Oms, Tatjana Schlechtweg, Safia Zedek, Laurence Van Melderen
Bactericidal antibiotics can cause metabolic perturbations that contribute to antibiotic-induced lethality. The molecular mechanism underlying these downstream effects remains unknown. Here, we show that ofloxacin, a fluoroquinolone that poisons DNA gyrase, induces a cascade of metabolic changes that are dependent on an active SOS response. We identified the SOS-regulated TisB protein as the unique molecular determinant responsible for cytoplasmic condensation, proton motive force dissipation, loss of pH homeostasis, and H2 O2 accumulation in Escherichia coli cells treated with high doses of ofloxacin...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536838/comparative-evaluation-of-different-modalities-for-measuring-in-vivo-carnosine-levels
#3
JOURNAL ARTICLE
Alok R Amraotkar, David Hoetker, Mohammad J Negahdar, Chin K Ng, Pawel Lorkiewicz, Ugochukwu S Owolabi, Shahid P Baba, Aruni Bhatnagar, Timothy E O'Toole
Carnosine is an endogenous di-peptide (β-alanine -L- histidine) involved in maintaining tissue homeostasis. It is most abundant in skeletal muscle where its concentration has been determined in biopsy samples using tandem mass spectrometry (MS-MS). Carnosine levels can also be assessed in intact leg muscles by proton magnetic resonance spectroscopy (1H-MRS) or in blood and urine samples using mass spectrometry. Nevertheless, it remains uncertain how carnosine levels from these distinct compartments are correlated with each other when measured in the same individual...
2024: PloS One
https://read.qxmd.com/read/38536767/a-halogen-bonding-2-rotaxane-shuttle-for-chloride-selective-optical-sensing
#4
JOURNAL ARTICLE
Hui Min Tay, Andrew Docker, Andrew Taylor, Paul D Beer
The first example of a [2]rotaxane shuttle capable of selective optical sensing of chloride anions over other halides is reported. The rotaxane was synthesised via a chloride ion template-directed cyclisation of an isophthalamide macrocycle around a multi-station axle containing peripheral naphthalene diimide (NDI) stations and a halogen bonding (XB) bis(iodotriazole) based station. Proton NMR studies indicate the macrocycle resides preferentially at the NDI stations in the free rotaxane, where it is stabilised by aromatic donor-acceptor charge transfer interactions between the axle NDI and macrocycle hydroquinone moieties...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38536754/multi-axis-fields-boost-sabre-hyperpolarization
#5
JOURNAL ARTICLE
Jacob R Lindale, Loren L Smith, Mathew W Mammen, Shannon L Eriksson, Lucas M Everhart, Warren S Warren
The inherently low signal-to-noise ratio of NMR and MRI is now being addressed by hyperpolarization methods. For example, iridium-based catalysts that reversibly bind both parahydrogen and ligands in solution can hyperpolarize protons (SABRE) or heteronuclei (X-SABRE) on a wide variety of ligands, using a complex interplay of spin dynamics and chemical exchange processes, with common signal enhancements between 103 and 104 . This does not approach obvious theoretical limits, and further enhancement would be valuable in many applications (such as imaging mM concentration species in vivo)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536704/networks-of-hydrogen-bond-networks-in-water-clusters
#6
JOURNAL ARTICLE
Andrey M Tokmachev
Water clusters play a prominent role in atmospheric and solution chemistry. Numerous arrangements of protons, H-bond configurations or networks, shape the cluster properties. Studies of small water clusters by cryogenic scanning tunneling microscopy and high-resolution rovibrational spectroscopy have established proton rearrangement mechanisms forming pathways between H-bond networks. The mechanisms, concerted tunneling in particular, describe the local processes connecting pairs of configurations. Here, proton rearrangement networks mapping these transformations are defined and explored to provide a global view of the H-bond configurations in clusters...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536479/applying-machine-learning-in-the-investigation-of-the-link-between-the-high-velocity-streams-of-charged-solar-particles-and-precipitation-induced-floods
#7
JOURNAL ARTICLE
Slavica Malinović-Milićević, Yaroslav Vyklyuk, Milan M Radovanović, Milan Milenković, Ana Milanović Pešić, Boško Milovanović, Teodora Popović, Petro Sydor, Marko D Petrović
This study explores a possible link between solar activity and floods caused by precipitation. For this purpose, discrete blocks of data for 89 separate flood events in Europe in the period 2009-2018 were used. Solar activity parameters with a time lag of 0-11 days were used as input data of the model, while precipitation data in the 12 days preceding the flood were used as output data. The level of randomness of the input and output time series was determined by correlation analysis, while the potential causal relationship was established by applying machine learning classification predictive modeling...
March 27, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38536017/effects-of-empagliflozin-on-liver-fat-in-metabolic-dysfunction-associated-steatotic-liver-disease-patients-without-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#8
JOURNAL ARTICLE
Ka Shing Cheung, Ho Yu Ng, Rex Wan Hin Hui, Lok Ka Lam, Lung Yi Mak, Yuen Chi Ho, Jing Tong Tan, Esther W Chan, Wai Kay Seto, Man Fung Yuen, Wai K Leung
BACKGROUND AND AIMS: We investigated whether empagliflozin reduces hepatic steatosis in metabolic-dysfunction associated steatotic liver disease (MASLD) patients without diabetes mellitus (DM). APPROACH AND RESULTS: This was an investigator-initiated, double-blind, randomized, placebo-controlled trial recruiting adult subjects from the community. Eligible subjects without DM (fasting plasma glucose <7 mmol/L and HbA1c <6.5%) who had magnetic resonance imaging-proton density fat fraction [MRI-PDFF] ≥5% were randomly allocated to receive empagliflozin 10 mg daily or placebo (1:1 ratio) for 52 weeks (end of treatment, EOT)...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535991/photocatalytic-conversion-of-co-2-to-co-by-ru-ii-and-os-ii-octahedral-complexes-a-dft-tddft-study
#9
JOURNAL ARTICLE
Athanassios C Tsipis, Antonia A Sarantou
The reaction mechanisms of the photocatalytic reduction of CO2 to CO catalyzed by [(en)M(CO)3 Cl] complexes (M = Ru, Os, en = ethylenediamine) in the presence of triethanolamine (TEOA), R3 N (R = -CH2 CH2 OH), in DCM and DMF solvents, were studied by means of DFT/TDDFT electronic structure calculations. The geometric and free energy reaction profiles for two possible reaction pathways were calculated. Both reaction pathways studied, start with the 17e- , catalytically active intermediate, [(en)M(CO)3 ]˙+ generated from the first triplet excited state, T1 upon reductive quenching by TEOA which acts as a sacrificial electron donor...
March 27, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38535674/synthesized-pani-ceo-2-nanocomposite-films-for-enhanced-anti-corrosion-performance
#10
JOURNAL ARTICLE
Ahmad M Alsaad, Mohannad Al-Hmoud, Taha M Rababah, Mohammad W Marashdeh, Mamduh J Aljaafreh, Sharif Abu Alrub, Ayed Binzowaimil, Ahmad Telfah
This study introduces a novel nanocomposite coating composed of PANI/CeO2 nanocomposite films, aimed at addressing corrosion protection needs. Analysis through FTIR spectra and XRD patterns confirms the successful formation of the nanocomposite films. Notably, the PANI/CeO2 nanocomposite films exhibit a hydrophilic nature. The bandgap energy of the PANI composite film is measured to be 3.74 eV, while the introduction of CeO2 NPs into the PANI matrix reduces the bandgap energy to 3.67 eV. Furthermore, the electrical conductivity of the PANI composite film is observed to be 0...
March 15, 2024: Nanomaterials
https://read.qxmd.com/read/38535280/effect-of-nio-addition-on-the-sintering-and-electrochemical-properties-of-bace-0-55-zr-0-35-y-0-1-o-3-%C3%AE-proton-conducting-ceramic-electrolyte
#11
JOURNAL ARTICLE
Chengxin Peng, Bingxiang Zhao, Xie Meng, Xiaofeng Ye, Ting Luo, Xianshuang Xin, Zhaoyin Wen
Proton ceramic fuel cells offer numerous advantages compared with conventional fuel cells. However, the practical implementation of these cells is hindered by the poor sintering activity of the electrolyte. Despite extensive research efforts to improve the sintering activity of BCZY, the systematic exploration of the utilization of NiO as a sintering additive remains insufficient. In this study, we developed a novel BaCe0.55 Zr0.35 Y0.1 O3-δ (BCZY) electrolyte and systematically investigated the impact of adding different amounts of NiO on the sintering activity and electrochemical performance of BCZY...
February 27, 2024: Membranes
https://read.qxmd.com/read/38535273/anti-inflammatory-antipyretic-and-analgesic-potential-of-chitin-and-chitosan-derived-from-cockroaches-periplaneta-americana-and-termites
#12
JOURNAL ARTICLE
Khushbakht Asad, Sumaira Shams, Eliana Ibáñez-Arancibia, Patricio R De Los Ríos-Escalante, Farhad Badshah, Farooq Ahmad, Muhammad Salman Khan, Asar Khan
The chitin and chitosan biopolymers are extremely valuable because of their numerous industrial and pharmacological uses. Chitin and chitosan were extracted from the exoskeleton of Periplaneta americana (cockroaches) and termites using various acid and alkali techniques. The extraction process involves an initial demineralization step, during which integument dry powder was subjected to 500 mL (2.07 mol/L) of concentrated HCl at 100 degrees Celsius for 30 min, followed by meticulous rinsing with distilled water to restore the pH to its baseline...
March 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535256/water-soluble-quaternary-and-protonable-basic-chitotriazolans-synthesis-by-click-chemistry-conversion-of-chitosan-azides-and-investigation-of-antibacterial-activity
#13
JOURNAL ARTICLE
Sankar Rathinam, Romano Magdadaro, Martha Á Hjálmarsdóttir, Már Másson
The azide transfer reaction and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) can be used to convert the amino groups in chitosan to triazole 1,2,3-moieties. The resulting polymer has been named chitotriazolan. This synthesis was performed with six different quaternary ammonium alkynes and three amine alkynes to obtain a series of nine water-soluble chitotriazolan derivatives. The structure and complete conversion of the azide were confirmed by FT-IR and proton NMR spectroscopy. The derivatives were investigated for antibacterial activity against S...
March 5, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535052/automatic-active-lesion-tracking-in-multiple-sclerosis-using-unsupervised-machine-learning
#14
JOURNAL ARTICLE
Jason Uwaeze, Ponnada A Narayana, Arash Kamali, Vladimir Braverman, Michael A Jacobs, Alireza Akhbardeh
BACKGROUND: Identifying active lesions in magnetic resonance imaging (MRI) is crucial for the diagnosis and treatment planning of multiple sclerosis (MS). Active lesions on MRI are identified following the administration of Gadolinium-based contrast agents (GBCAs). However, recent studies have reported that repeated administration of GBCA results in the accumulation of Gd in tissues. In addition, GBCA administration increases health care costs. Thus, reducing or eliminating GBCA administration for active lesion detection is important for improved patient safety and reduced healthcare costs...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38534336/progressive-irreversible-proprioceptive-piezo2-channelopathy-induced-lost-forced-peripheral-oscillatory-synchronization-to-the-hippocampal-oscillator-may-explain-the-onset-of-amyotrophic-lateral-sclerosis-pathomechanism
#15
JOURNAL ARTICLE
Balázs Sonkodi
Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative disease that gradually leads to the progressive loss of motor neurons. A recent non-contact dying-back injury mechanism theory for ALS proposed that the primary damage is an acquired irreversible intrafusal proprioceptive terminal Piezo2 channelopathy with underlying genetic and environmental risk factors. Underpinning this is the theory that excessively prolonged proprioceptive mechanotransduction under allostasis may induce dysfunctionality in mitochondria, leading to Piezo2 channelopathy...
March 12, 2024: Cells
https://read.qxmd.com/read/38534147/size-dependent-deformation-and-competition-h-bond-site-induced-individual-fluorescence-response-of-a-single-crystal-three-dimensional-covalent-organic-framework
#16
JOURNAL ARTICLE
Yan Wang, Xu-Qin Ran, Cheng Yang, Hai-Long Qian, Xiu-Ping Yan
Understanding the individual fluorescence response mechanism of covalent organic frameworks (COFs) at a single-crystal level is of great significance for the rational design of COF-based microsensors but unreachable because all previous COF-based sensors are performed with average fluorescence response behavior of various sized polycrystalline COFs. Herein, we design to explore the fluorescence response of a monodisperse single-crystal COF and further reveal the individual heterogeneity of the response mechanism...
March 27, 2024: Analytical Chemistry
https://read.qxmd.com/read/38533873/-not-available
#17
JOURNAL ARTICLE
Maja Vestmø Maraldo, Birgitte Vrou Offersen
In early breast cancer, adjuvant moderately hypofractionated regimens are recommended for both whole breast, partial breast and locoregional irradiation which abbreviates the overall treatment time, as argued in this review. Gating is recommended as well as the use of a simultaneous integrated boost when indicated. A tangential field set-up is standard, however, for challenging cases volumetric modulated arc therapy techniques, or referral for proton therapy, may be considered. In the metastatic setting, stereotactic radiotherapy is a promising treatment option for oligometastatic disease...
March 18, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533705/hsqc-spectra-simulation-and-matching-for-molecular-identification
#18
JOURNAL ARTICLE
Martin Priessner, Richard J Lewis, Magnus J Johansson, Jonathan M Goodman, Jon Paul Janet, Anna Tomberg
In the pursuit of improved compound identification and database search tasks, this study explores heteronuclear single quantum coherence (HSQC) spectra simulation and matching methodologies. HSQC spectra serve as unique molecular fingerprints, enabling a valuable balance of data collection time and information richness. We conducted a comprehensive evaluation of the following four HSQC simulation techniques: ACD/Labs (ACD), MestReNova (MNova), Gaussian NMR calculations (DFT), and a graph-based neural network (ML)...
March 27, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38532609/proton-pump-inhibitors-enhance-macropinocytosis-mediated-extracellular-vesicle-endocytosis-by-inducing-membrane-v-atpase-assembly
#19
JOURNAL ARTICLE
Xinliang Lu, Zhengbo Song, Jiayue Hao, Xianghui Kong, Weiyi Yuan, Yingying Shen, Chengyan Zhang, Jie Yang, Pengfei Yu, Yun Qian, Gensheng Zhang, Huajun Feng, Jianli Wang, Zhenzhai Cai, Zhijian Cai
Besides participating in diverse pathological and physiological processes, extracellular vesicles (EVs) are also excellent drug-delivery vehicles. However, clinical drugs modulating EV levels are still lacking. Here, we show that proton pump inhibitors (PPIs) reduce EVs by enhancing macropinocytosis-mediated EV uptake. PPIs accelerate intestinal cell endocytosis of autocrine immunosuppressive EVs through macropinocytosis, thereby aggravating inflammatory bowel disease. PPI-induced macropinocytosis facilitates the clearance of immunosuppressive EVs from tumour cells, improving antitumor immunity...
April 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38532537/concentration-dependent-asymmetric-synergy-in-sds-ddao-mixed-surfactant-micelles
#20
JOURNAL ARTICLE
Luis M G Torquato, Gunjan Tyagi, William N Sharratt, Zain Ahmad, Najet Mahmoudi, Jérémie Gummel, Eric S J Robles, João T Cabral
We investigate the structure and interactions of a model anionic/amphoteric mixed surfactant micellar system, namely, sodium dodecyl sulfate (SDS) and N , N -dimethyldodecylamine N -oxide (DDAO), employing SANS, FTIR, DLS, and pH measurements, in the range 0.1-100 mM total surfactant concentration and 0-100% DDAO. Increasing surfactant concentration is found to elongate the prolate ellipsoid micelles ( R Polar ∼ 25-40 Å), accompanied by up to a 6-fold increase in micellar charge. The surfactant synergy, in terms of micellar charge and size, diffusion coefficient, solution pH, and headgroup interactions, was found to vary with concentration...
March 26, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
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