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https://www.readbyqxmd.com/read/28823009/proton-pump-inhibitors-as-risk-factor-for-metabolic-syndrome-and-hepatic-steatosis-in-coeliac-disease-patients-on-gluten-free-diet
#1
Nicola Imperatore, Raffaella Tortora, Testa Anna, Nicolò Gerbino, Nicola Caporaso, Antonio Rispo
BACKGROUND: Recent research has shown that patients with coeliac disease (CD) are at risk of developing metabolic syndrome (MS) and hepatic steatosis (HS) after commencing a gluten-free diet (GFD). This study aimed to evaluate the predictive factors for MS and HS in CD after 1 year of GFD. METHODS: All consecutive newly diagnosed CD patients were enrolled. We prospectively collected data about BMI; waist circumference; blood pressure; cholesterol; triglycerides, glucose and insulin blood levels; insulin resistance (through the homeostatic model assessment HOMA-IR) and treatment with proton pump inhibitors (PPI)...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28822844/a-ph-sensitive-methenamine-mandelate-loaded-nanoparticle-induces-dna-damage-and-apoptosis-of-cancer-cells
#2
Linhua Zhang, Wenbo Hao, Lv Xu, Yongfeng Gao, Xusheng Wang, Dunwan Zhu, Zhuo Chen, Xudong Zhang, Hongbo Chen, Lin Mei
Methenamine mandelate is a urinary antibacterial agent, which can be converted to formaldehyde in urine that has a relatively low pH of average 5.5-6.8. Here, we prepare a pH-sensitive PLGA-based nanoparticle containing both methenamine mandelate and NaHCO3. Methenamine mandelate/NaHCO3-coloaded nanoparticle could enter cells via endosome/lysosome pathway. The pH in lysosomes and endo-lysosomes is approximately 5.0. In the acidic environment, NaHCO3 reacts with proton and produce CO2 bubbles, which burst nanoparticles and lead to the rapidly release of methenamine mandelate...
August 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28822272/b24n24-fullerene-as-a-carrier-for-5-fluorouracil-anti-cancer-drug-delivery-dft-studies
#3
Mehrnoosh Khodam Hazrati, Zahra Javanshir, Zargham Bagheri
It has been previously indicated that BN nanostructures may be nontoxic and biocompatible. Here the potential application of a B24N24 is explored as a drug delivery system for anti-cancer 5-fluorouracil based on the density functional theory. This drug prefers to attach via its oxygen atoms to the B atoms of the cluster with adsorption energy about -11.90kcalmol(-1) based on the dispersion corrected B3LYP level of theory. To make the cluster more appropriate for drug delivery, we replaced a B atom by Si or Al atom to improve the interaction strength...
August 9, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28821929/magnetic-resonance-cinematography-of-the-fingers-a-3-0-tesla-feasibility-study-with-comparison-of-incremental-and-continuous-dynamic-protocols
#4
Thomas Bayer, Werner Adler, Rolf Janka, Michael Uder, Frank Roemer
OBJECTIVE: To study the feasibility of magnetic resonance cinematography of the fingers (MRCF) with comparison of image quality of different protocols for depicting the finger anatomy during motion. MATERIALS AND METHODS: MRCF was performed during a full flexion and extension movement in 14 healthy volunteers using a finger-gating device. Three real-time sequences (frame rates 17-59 images/min) and one proton density (PD) sequence (3 images/min) were acquired during incremental and continuous motion...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28821859/reduction-of-the-off-pathway-iron-sulphur-cluster-n1a-of-escherichia-coli-respiratory-complex-i-restrains-nad-dissociation
#5
Emmanuel Gnandt, Johannes Schimpf, Caroline Harter, Jo Hoeser, Thorsten Friedrich
Respiratory complex I couples the electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. The reaction starts with NADH oxidation by a flavin cofactor followed by transferring the electrons through a chain of seven iron-sulphur clusters to quinone. An eighth cluster called N1a is located proximally to flavin, but on the opposite side of the chain of clusters. N1a is strictly conserved although not involved in the direct electron transfer to quinone. Here, we show that the NADH:ferricyanide oxidoreductase activity of E...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821850/comparative-metabonomics-of-wenxin-keli-and-verapamil-reveals-differential-roles-of-gluconeogenesis-and-fatty-acid-%C3%AE-oxidation-in-myocardial-injury-protection
#6
Miaomiao Jiang, Qiuying Wang, Jingrui Chen, Yanan Wang, Guanwei Fan, Yan Zhu
Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, the application of which has led to understanding pathophysiologic mechanisms of cardiometabolic diseases, defining predictive biomarkers for those diseases, and also assessing the efficacious effects of incident drugs. In this study, proton nuclear magnetic resonance (NMR)-based metabonomics was employed to identify the metabolic changes in rat plasma caused by myocardial ischemia-reperfusion injury (MIRI), and to compare the metabolic regulatory differences between traditional Chinese medicine Wenxin Keli (WXKL) and Western medicine verapamil...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821751/structure-sensitive-photocatalytic-reduction-of-nitroarenes-over-tio-2
#7
Swapna Challagulla, Kartick Tarafder, Ramakrishnan Ganesan, Sounak Roy
It is a subject of exploration whether the phase pure anatase or rutile TiO2 or the band alignment due to the heterojunctions in the two polymorphs of TiO2 plays the determining role in efficacy of a photocatalytic reaction. In this work, the phase pure anatase and rutile TiO2 have been explored for photocatalytic nitroarenes reduction to understand the role of surface structures and band alignment towards the reduction mechanism. The conduction band of synthesized anatase TiO2 has been found to be more populated with electrons of higher energy than that of synthesized rutile...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821300/t1-refblochi-high-resolution-3d-post-contrast-t1-myocardial-mapping-based-on-a-single-3d-late-gadolinium-enhancement-volume-bloch-equations-and-a-reference-t1
#8
Chenxi Hu, Albert J Sinusas, Steffen Huber, Stephanie Thorn, Mitchel R Stacy, Hamid Mojibian, Dana C Peters
BACKGROUND: High resolution 3D T1 mapping is important for assessment of diffuse myocardial fibrosis in left atrium or other thin-walled structures. In this work, we investigated a fast single-TI 3D high resolution T1 mapping method that directly transforms a 3D late gadolinium enhancement (LGE) volume to a 3D T1 map. METHODS: The proposed method, T1-refBlochi, is based on Bloch equation modeling of the LGE signal, a single-point calibration, and assumptions that proton density and T2* are relatively uniform in the heart...
August 18, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28821215/implementation-of-global-strategies-to-prevent-hospital-onset-clostridium-difficile-infection-targeting-proton-pump-inhibitors-and-probiotics
#9
Paul O Lewis, Timothy S Lundberg, Jennifer L Tharp, Clay W Runnels
BACKGROUND: Proton pump inhibitors (PPIs) have been identified as a significant risk factor for the development of Clostridium difficile infection (CDI). Probiotics given concurrently with antibiotics have been shown to have a moderate impact on preventing CDI. OBJECTIVE: To evaluate the effectiveness of hospital-wide interventions designed to reduce PPI use and increase probiotics and whether these interventions were associated with a change in the incidence of hospital onset (HO)-CDI...
August 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28821156/physicochemical-interactions-of-cycloamylose-with-phenolic-compounds
#10
Shin-Joung Rho, Saehun Mun, Jung Sun Hong, Young-Lim Kim, Ha V Do, Young-Wan Kim, Sang-Ik Han, Yong-Ro Kim
The complex formation capability of cycloamylose (CA), having a degree of polymerization of 23-45, with phenolic compounds (PCs) was investigated using various physicochemical techniques. The fluorescence intensity of PCs increased and then reached a plateau at 10-20mM cyclodextrin, while it continued to increase at up to 60mM CA. Thermodynamic data of CA complexes with PCs revealed that the binding process was primarily enthalpy-driven and spontaneous. CA favored to form the most stable complex with chlorogenic acid (CHA) among all PCs...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821111/a-facile-sodium-alginate-based-approach-to-improve-the-mechanical-properties-of-recycled-fibers
#11
Yuan-Yuan Bai, Yan-Hao Lei, Xiao-Jun Shen, Jing Luo, Chun-Li Yao, Run-Cang Sun
The application of recycled fibers is steadily increasing in various paper products recently. It is necessary to improve the mechanical properties of paper products made from these fibers. An eco-friendly polymeric additive, sodium alginate (SA), was prepared from waste seaweeds and developed as functional additives. The properties of SA were characterized by proton nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermal gravity analysis, gel permeation chromatography, and compared with the commercial SA...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821085/dissolution-mechanism-of-cellulose-in-quaternary-ammonium-hydroxide-revisiting-through-molecular-interactions
#12
Chao Zhong, Fang Cheng, Yingkui Zhu, Zhen Gao, Honghua Jia, Ping Wei
Quaternary ammonium hydroxide (QAH) solution has been used to dissolve cellulose and made great progress in recent years. While, its cellulose dissolution mechanism is still in unclear. Here, series of QAH with varied cationic alkyl chains were chosen for the investigation. The solubility of cellulose in QAH was measured, which allowed us to study the effect of cationic structure on cellulose dissolution. Also, the Kamlet-Taft parameters as well as 1D and 2D NMR analyses of QAH-cellulose/cellobiose system were measured...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820933/surface-chemistry-of-la0-99sr0-01nbo4-d-and-its-implication-for-proton-conduction
#13
Cheng Li, Stevin S Pramana, Na Ni, John A Kilner, Stephen J Skinner
Acceptor doped LaNbO4 is a promising electrolyte material for proton conducting fuel cell (PCFC) applications. As charge transfer processes govern device performance, the outermost surface of acceptor doped LaNbO4 will play an important role in determining the overall cell performance. However, the surface composition is poorly characterized, and the understanding of its impact on the proton exchange process is rudimentary. In this work, the surface chemistry of 1 at% Sr doped LaNbO4 (La0.99Sr0.01NbO4-d, denoted as LSNO) proton conductor is characterized using LEIS and SIMS...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820594/on-the-restrained-proton-indicator-in-combined-quantum-mechanics-molecular-mechanics-dynamics-simulations-of-proton-transfer-through-a-carbon-nanotube
#14
Adam W Duster, Hai Lin
Recently, a collective variable "proton indicator" was purposed for tracking an excess proton solvated in bulk water in molecular dynamics simulations. In this work, we demonstrate the feasibility of utilizing the position of this proton indicator as a reaction coordinate to model an excess proton migrating through a hydrophobic carbon nanotube in combined quantum-mechanics/molecular-mechanics simulations. Our results indicate that applying a harmonic restraint to the proton indicator in the bulk solvent near the nanotube pore entrance leads to the recruitment of water molecules into the pore...
August 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28820585/chemo-enzymatic-assembly-of-isotopically-labeled-folates
#15
Antonio Angelastro, William Michael Dawson, Louis Y P Luk, E Joel Loveridge, Rudolf K Allemann
Pterin-containing natural products have diverse functions in life but an efficient and easy scheme for their in vitro synthesis is not available. Here, we report a chemo-enzymatic 14-step, one-pot synthesis that can be used to generate 13C- and 15N-labeled dihydrofolates (H2F) from glucose, guanine and p-aminobenzoyl-L-glutamic acid. This synthesis stands out from previous approaches to produce H2F in that the average yield of each step is >91% and it requires only one single purification step. The use of a one-pot reaction allowed us to overcome potential problems with individual steps during the synthesis...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820529/reactions-between-microhydrated-superoxide-anions-and-formic-acid
#16
Mauritz Johan Ryding, Israel Fernández, Einar Uggerud
Reactions between water clusters containing the superoxide anion, O2˙(-)(H2O)n (n = 0-4), and formic acid, HCO2H, were studied experimentally in vacuo and modelled using quantum chemical methods. Encounters between microhydrated superoxide and formic acid were found to result in a number of different reactions, including (a) proton transfer, (b) ligand exchange, (c) H2-elimination (affording microhydrated CO4˙(-)), and (d) dihydrogen transfer (affording H2O2 and microhydrated CO2˙(-)). The effect of reactant-ion hydration on reaction rates was investigated and the involved reaction mechanisms were elucidated...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28820311/clinical-radiobiology-of-proton-therapy-modeling-of-rbe
#17
B Jones
PURPOSE: To better estimate relative biological effectiveness (RBE) in therapeutic proton beams by using a modeled approach, in order to improve their clinical safety and effectiveness. INTRODUCTION: Concerns exist about the 1.1 RBE used in proton therapy, since it may lead to unintentional over- and under-dosage in patients and so lead to unexpected clinical outcomes. Late reacting normal tissues (with low α/β values), might be overdosed if RBE >1.1; very radiosensitive tumors (with high α/β), might be under-dosed if RBE <1...
August 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28820221/real-time-monitoring-of-plasmon-induced-proton-transfer-of-hypoxanthine-in-serum
#18
Binbin Zhou, Shaofei Li, Xianghu Tang, Pan Li, Xiaomin Cao, Borong Yu, Liangbao Yang, Jinhuai Liu
Intramolecular proton transfer of hypoxanthine, induced by application of a laser on the surface of a bare noble nanomaterial, was monitored in real time using surface-enhanced Raman spectroscopy (SERS). This monitoring demonstrated the dependence of the reaction on the identity of the nanomaterial and on the laser power density. The results pave the way for monitoring the proton transfer reaction in various relevant fields. In addition, we observed the presence of the proton transfer phenomenon of hypoxanthine in serum, providing a way to avoid the effect of proton transfer and hence achieve more reliable spectra of sera for clinical diagnosis...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28820214/mediated-water-electrolysis-in-biphasic-systems
#19
Micheál D Scanlon, Pekka Peljo, Lucie Rivier, Heron Vrubel, Hubert H Girault
The concept of efficient electrolysis by linking photoelectrochemical biphasic H2 evolution and water oxidation processes in the cathodic and anodic compartments of an H-cell, respectively, is introduced. Overpotentials at the cathode and anode are minimised by incorporating light-driven elements into both biphasic reactions. The concepts viability is demonstrated by electrochemical H2 production from water splitting utilising a polarised water-organic interface in the cathodic compartment of a prototype H-cell...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28820199/tuning-the-copper-ii-coordination-properties-of-cyclam-by-subtle-chemical-modifications
#20
Nathalie Camus, Nathalie Le Bris, Selbi Nuryyeva, Matthieu Chessé, David Esteban-Gómez, Carlos Platas-Iglesias, Raphaël Tripier, Mourad Elhabiri
The acid-base and copper(ii) coordination properties of three previously described cyclam derivatives are reported. Potentiometry, mass spectrometry, UV-vis absorption spectroscopy, electrochemistry and theoretical calculations were combined to investigate the protonation and binding properties of Bn-cyclam-EtOH (L1), oxo-cyclam-EtOH (L2) and oxo-Bn-cyclam-EtOH (L3). These three cyclams are C-functionalized by a hydroxyethyl pendant arm and display either one N-benzyl group and/or an amide replacing one macrocyclic secondary amine...
August 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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