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https://www.readbyqxmd.com/read/28645010/a-rare-case-of-male-pseudohermaphroditism-persistent-mullerian-duct-syndrome-with-transverse-testicular-ectopia-case-report-and-review-of-literature
#1
Aashish Rajesh, Mohammed Farooq
INTRODUCTION: Persistent Mullerian duct syndrome (PMDS) is a rare type of male pseudohermaphroditism. Transverse testicular ectopia (TTE) is characterized by one testis moving to the opposite side and both testes traversing the same inguinal canal. CASE PRESENTATION: An 11-month-old boy presented with bilateral cryptorchidism. The left testis was not palpable; the right testis was canalicular with a right inguinal hernia. Ultrasound showed both testes located in the right inguinal canal...
June 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28641034/imaging-of-proximal-lacrimal-system-with-time-domain-anterior-segment-optical-coherence-tomography-in-asian-indian-population
#2
Swati Singh, Arnav Ghosh, Suryasnata Rath
This article reports proximal lacrimal system parameters using Anterior Segment Optical Coherence Tomography (ASOCT-Visante) in an apparently normal Asian Indian population with assessment of any correlation between tear meniscus height and punctal diameter. This was a prospectively designed observational study that included healthy adults, who volunteered for optical coherence tomography imaging (OCT) of their proximal lacrimal system. Time domain ASOCT (Visante) images of the punctum and proximal canaliculus were captured using the high resolution corneal scan protocol...
June 22, 2017: Orbit
https://www.readbyqxmd.com/read/28641033/evaluation-of-planned-bicanalicular-nasolacrimal-tube-retention-in-treating-punctal-stenosis-or-occlusion-secondary-to-trachoma
#3
Rania A Ahmed, Ahmed M Kamal, Mohamed A Zayed
This article evaluates retaining bicanalicular silicone nasolacrimal tube in patients susceptible to restenosis after punctoplasty. Sixty-nine eyes (38 patients) suffering from epiphora due to stenosis or occlusion of both punctae were included in this prospective study. All had 3 snip punctoplasty and bicanalicular silicone nasolacrimal duct insertion. Cases associated with proximal canalicular stenosis or obstructions were excluded. Tolerance to tube presence until the time of loss or removal was evaluated using a score (0 to 2)...
June 22, 2017: Orbit
https://www.readbyqxmd.com/read/28634191/cd36-knockout-mice-are-protected-against-lithogenic-diet-induced-gallstones
#4
Yan Xie, Vincenza Cifarelli, Terri Pietka, Elizabeth P Newberry, Susan M Kennedy, Amin Khalifeh-Soltani, Robin Clugston, Kamran Atabai, Nada A Abumrad, Nicholas O Davidson
The scavenger receptor and multiligand transporter CD36 functions to promote cellular free fatty acid uptake and regulates aspects of both hepatic and intestinal cholesterol metabolism. However, the role of CD36 in regulating canalicular and biliary cholesterol transport and secretion is unknown. Here we show that germline Cd36 knockout mice are protected against lithogenic diet (LD) induced gallstones compared to congenic (C57BL6/J) controls. Cd36 knockout mice crossed into congenic L-Fabp knockout mice (DKO mice) demonstrated protection against LD induced gallstones, reversing the susceptibility phenotype observed in L-Fabp knockout mice...
June 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28612126/immaturity-of-bile-canalicular-ductule-networks-in-the-future-liver-remnant-while-associating-liver-partition-and-portal-vein-occlusion-for-staged-hepatectomy-alpps
#5
Kenichi Matsuo, Yukihiko Hiroshima, Kazuto Yamazaki, Kohei Kasahara, Yutaro Kikuchi, Daisuke Kawaguchi, Takashi Murakami, Yasuo Ishida, Kuniya Tanaka
BACKGROUND: We studied histologic changes of bile canalicular-ductule networks in the future liver remnant (FLR) while associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS), since little is known about regeneration of these networks during the relatively short interval between procedures in ALPPS. METHODS: Bile canalicular-ductule networks were examined in specimens from eight patients treated with ALPPS and six patients undergoing hepatectomy following portal vein embolization (PVE)...
June 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28611441/label-free-imaging-of-bone-multiscale-porosity-and-interfaces-using-third-harmonic-generation-microscopy
#6
Rachel Genthial, Emmanuel Beaurepaire, Marie-Claire Schanne-Klein, Françoise Peyrin, Delphine Farlay, Cécile Olivier, Yohann Bala, Georges Boivin, Jean-Claude Vial, Delphine Débarre, Aurélien Gourrier
Interfaces provide the structural basis of essential bone functions. In the hierarchical structure of bone tissue, heterogeneities such as porosity or boundaries are found at scales ranging from nanometers to millimeters, all of which contributing to macroscopic properties. To date, however, the complexity or limitations of currently used imaging methods restrict our understanding of this functional integration. Here we address this issue using label-free third-harmonic generation (THG) microscopy. We find that the porous lacuno-canalicular network (LCN), revealing the geometry of osteocytes in the bone matrix, can be directly visualized in 3D with submicron precision over millimetric fields of view compatible with histology...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590786/liver-fibrosis-associated-with-crigler-najjar-syndrome-in-a-compound-heterozygote
#7
Cynthia R Fata, Lynette A Gillis, M Cristina Pacheco
Crigler-Najjar syndrome is a hereditary unconjugated hyperbilirubinemia. Two forms of the disease are recognized. Type I is more severe and results in kernicterus if left untreated, and Type II is less severe and responds to phenobarbital. While Crigler-Najjar syndrome is thought by many to have normal liver histology, few reports of the liver pathology exist. Herein, we present a 19-year-old patient with Crigler-Najjar who underwent liver transplantation. The liver showed marked canalicular cholestasis with portal and variable, delicate, bridging fibrosis...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28582376/spontaneous-canalicular-plug-erosion-after-punctal-plug-placement
#8
Charudutt Kalamkar, Amrita Mukherjee, Anoop Chandak
No abstract text is available yet for this article.
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28576205/incision-sparing-management-of-canaliculitis-an-efficacious-alternative-to-surgical-management
#9
David Zhiwei Law, E-Shawn Goh
OBJECTIVE: The aim of this study was to describe the outcomes of conservative (punctal dilation, manual expression, microcurettage, and canalicular irrigation with antibiotics) and surgical (punctoplasty) modalities for the management of canaliculitis in an Asian population. METHODS: The medical records of 11 consecutive patients (12 eyes) presenting with canaliculitis to one surgeon from August 2010 to January 2014 were reviewed. The clinical presentation, findings, management, microbiology, and treatment outcomes were studied...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28552422/8-methoxypsoralen-disrupts-mdr3-mediated-phospholipids-efflux-and-bile-acid-homeostasis-and-its-relevance-to-hepatotoxicity
#10
Guolin Zhao, Dengqiu Xu, Ziqiao Yuan, Zhenzhou Jiang, Wang Zhou, Zhijian Li, Mengyue Yin, Zhixing Zhou, Luyong Zhang, Tao Wang
Since its discovery in 1987, multidrug resistance 3 P-glycoprotein (MDR3) had recognized to play a crucial role in the translocation of phospholipids from the inner to outer leaflets of bile canalicular membranes. An increasing number of reports suggest that drug-mediated functional disruption of MDR3 is responsible for drug-induced cholestasis. 8-Methoxypsoralen (8-MOP) is used clinically to treat psoriasis, vitiligo and other skin disorders. However, psoralens safety for long-term use is a concern. In the current study, we evaluate 8-MOP's potential hepatotoxicity and effects on bile formation...
May 24, 2017: Toxicology
https://www.readbyqxmd.com/read/28540494/dacryoendoscopy-guided-transcanalicular-intralesional-interferon-alpha-2b-for-canalicular-squamous-papillomas
#11
Mohammad Javed Ali, Swati Singh, Anasua Ganguly, Milind N Naik
Canalicular papillomatosis is a rare disorder characterized by a mass lesion arising from the epithelium as a stalk from one of the canalicular walls. Traditionally, they have been treated with an open canaliculotomy and excision biopsy with or without additional cryotherapy. A patient with upper canalicular squamous papillomas treated with dacryoendoscopy-guided transcanalicular intralesional and topical interferon alpha 2b is presented, and the ineffectiveness of interferons in this case is discussed.
May 24, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28532833/estimation-of-fetal-lung-development-using-quantitative-analysis-of-ultrasonographic-images-in-normal-canine-pregnancy
#12
T Banzato, G Zovi, C Milani
We investigated the quantitative analysis of sonographic images to predict fetal lung maturity of the canine foetus in normal pregnancy. Twelve bitches were recruited in the present study. Serial ultrasonographic exams were performed at three pre-determined time periods corresponding to the pseudoglandular (40-48 days of pregnancy), canalicular (49-56 days of pregnancy) and saccular phase (57-63 days of pregnancy) of lung development. Mean grey level (MGL) and the standard deviation of the histogram (SDH) of fetal lung and liver sonographic images were measured with dedicated software...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28524363/donor-transmitted-mutation-of-the-abcb11-gene-and-ensuing-intra-hepatic-cholestasis-of-pregnancy-in-a-liver-transplant-recipient
#13
Tiong Yeng Lim, Iona Coltart, Pierre Foskett, Richard Thompson, Sandra Strautnieks, Leonie Penna, Catherine Williamson, Rosa Miquel, Michael A Heneghan
In liver transplant (LT) recipients, the cause of graft dysfunction in pregnancy is often difficult to ascertain. Moreover, a liver biopsy in late pregnancy is often avoided as a consequence of patient and physician factors. Management of graft dysfunction can be difficult in this setting. We report a 30-year-old female LT recipient who developed acutely deranged liver biochemistry during the third trimester of her first pregnancy. At 29 weeks gestation, her liver function test (LFT) became abnormal; AST peaked at 978 IU/L (normal range 10-50), GGT 25 IU/L (normal range 1-55), bilirubin 1...
May 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28523374/capturing-microscopic-features-of-bone-remodeling-into-a-macroscopic-model-based-on-biological-rationales-of-bone-adaptation
#14
Young Kwan Kim, Yoshitaka Kameo, Sakae Tanaka, Taiji Adachi
To understand Wolff's law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account...
May 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28516728/increased-heterogeneity-of-airway-calibre-in-adult-rats-after-hypoxia-induced-intrauterine-growth-restriction
#15
Kimberley C W Wang, Jude S Morton, Sandra T Davidge, Alexander N Larcombe, Alan L James, Graham M Donovan, Peter B Noble
BACKGROUND AND OBJECTIVE: Intrauterine growth restriction (IUGR) is associated with asthma development. We hypothesized that IUGR disrupts airway development leading to postnatal structural abnormalities of the airway that predispose to disease. This study therefore examined structural changes to the airway and lung in a rat model of maternal hypoxia-induced IUGR. METHODS: Pregnant rats were housed under hypoxic conditions (11.5% O2 ) from gestational days (GDs) 13 to 20 (pseudoglandular-canalicular stages, i...
May 17, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28513491/results-of-a-new-mirror-tuck-technique-for-fixation-of-lacrimal-bypass-tube-in-conjunctivodacryocystorhinostomy
#16
Ruchi Goel, Divya Kishore, Smriti Nagpal, Sushil Kumar, Neha Rathie
CONTEXT: Conjunctivodacryocystorhinostomy (CDCR) is the procedure of choice for proximal canalicular blocks. However, the complications of tube migration and extrusion limit its widespread practice. AIM: The aim of this study is to evaluate the efficacy and complications of the new "mirror tuck technique" for fixation of lacrimal bypass glass tube without holes in proximal canalicular blocks in laser CDCR. MATERIALS AND METHODS: A prospective interventional study was conducted in forty consecutive eyes of adult patients, undergoing 980 nm diode laser CDCR for proximal canalicular blocks...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28492981/evidence-that-osteocytes-in-autogenous-bone-fragments-can-repair-disrupted-canalicular-networks-and-connect-with-osteocytes-in-de-novo-formed-bone-on-the-fragment-surface
#17
Furqan A Shah, Anders Palmquist
Autogenous bone fragments generated during surgery (e.g. implant site preparation) accelerate bone formation by the release of a large variety of growth factors from the extracellular matrix and the cells contained within. Osteocytes, whether viable or apoptotic, within such fragments are able to recruit osteoclasts to a site of bone remodelling. Here, using correlative scanning electron microscopy, we provide compelling evidence that at one week healing in the Sprague Dawley rat tibia, following surgery (and/or the placement of a bone-anchored implant), autogenous bone fragments support bone formation on their surface...
May 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28481222/hepatic-metal-ion-transporter-zip8-regulates-manganese-homeostasis-and-manganese-dependent-enzyme-activity
#18
Wen Lin, David R Vann, Paschalis-Thomas Doulias, Tao Wang, Gavin Landesberg, Xueli Li, Emanuela Ricciotti, Rosario Scalia, Miao He, Nicholas J Hand, Daniel J Rader
Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with the regulation of whole-blood manganese (Mn) and multiple physiological traits. SLC39A8 encodes ZIP8, a divalent metal ion transporter best known for zinc transport. Here, we hypothesized that ZIP8 regulates Mn homeostasis and Mn-dependent enzymes to influence metabolism. We generated Slc39a8-inducible global-knockout (ZIP8-iKO) and liver-specific-knockout (ZIP8-LSKO) mice and observed markedly decreased Mn levels in multiple organs and whole blood of both mouse models...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28478831/hepatitis-c-virus-may-have-an-entero-hepatic-cycle-which-could-be-blocked-with-ezetimibe
#19
Hugo Monrroy, Marcelo López-Lastra, Alejandro Soza
Hepatitis C virus can lead to chronic infection, cirrhosis and hepatocellular carcinoma. With more than 170 million people infected worldwide, eradication remains a challenge even with the revolutionary current direct antiviral agents (DAAs). The risk of resistance, the safety profile in some populations, the genotype specificity and the high price of current DAAs explain why there is still interest in developing host targeting agents (HTA) that may help overcome some of these difficulties. Specifically, targeting the entry of HCV to the cell seems like a promising strategy...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28470757/osteocytes-acidify-their-microenvironment-in-response-to-pthrp-in-vitro-and-in-lactating-mice-in-vivo
#20
Katharina Jähn, Shilpa Kelkar, Hong Zhao, Yixia Xie, LeAnn M Tiede-Lewis, Vladimir Dusevich, Sarah L Dallas, Lynda F Bonewald
Osteocytes appear to mobilize calcium within minutes in response to PTH injections and we have previously shown that osteocytes remove their perilacunar matrix during lactation through activation of the PTH type 1 receptor. Mechanisms utilized by osteocytes to mobilize calcium are unknown but we hypothesized that the molecular components may be similar to those used by osteoclasts. Here we show, using IDG-SW3 cells that ATP6V0D2, an essential component of vacuolar ATPase in osteoclasts, and other genes associated with osteoclastic bone resorption increase with osteoblast to osteocyte differentiation...
May 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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