keyword
MENU ▼
Read by QxMD icon Read
search

canalicular

keyword
https://www.readbyqxmd.com/read/28821575/ldl-switches-the-lrp6-internalization-route-from-flotillin-dependent-to-clathrin-dependent-in-hepatic-cells
#1
Hideki Yamamoto, Daisuke Umeda, Shinji Matsumoto, Akira Kikuchi
Low-density lipoprotein (LDL) receptor-related protein 6 (LRP6) was originally identified as a coreceptor of the Wnt signaling pathway and has been shown to be involved in LDL transport. In polarized hepatocytes, many apical proteins are sorted to the basolateral membrane and then internalized and transported to the apical bile canalicular membrane-a process known as transcytosis. Herein, we show that LRP6 is transcytosed to the apical membrane of polarized hepatic HepG2 cells via a flotillin-dependent manner in the absence of LDL...
August 18, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28820185/can-lester-jones-tubes-be-tolerated-for-decades
#2
R L Scawn, D H Verity, G E Rose
PurposeLester Jones described canalicular bypass tubes 50 years ago. We present a cohort of patients with Jones' tubes first placed between 1969 and 1989, and who were reviewed within the last 15 years.Patients and methodsRetrospective case-note review for living patients identified as having had Jones' tube placement prior to 1990. The duration of Jones' tube usage was noted and the number of replacements recorded.ResultsTwenty-nine patients (33 eyes) had maintenance of their Jones' tube(s) within the last 15 years, and had first tube placement before 1990...
August 18, 2017: Eye
https://www.readbyqxmd.com/read/28816979/a-new-method-for-locating-the-proximal-lacerated-bicanalicular-ends-in-chinese-preschoolers-and-long-term-outcomes-after-surgical-repair
#3
Ai Zhuang, Xiaoliang Jin, Yinwei Li, Xianqun Fan, Wodong Shi
This report is to explore the long-term outcomes of surgical repair of bicanalicular lacerations in Chinese preschool patients. In this report, 12 patients with bicanalicular lacerations were studied between September 2010 and September 2015. The distance from the punctum to the distal canalicular lacerated end was recorded before surgery to classify different types of trauma. All patients underwent surgical repair of the lacerated canaliculi by 1 surgeon within 48 hours after the trauma occurred. After treatment, the lesions were divided into 3 types according to the distance from the punctum to the distal lacerated canalicular end as follows: lateral, medial, and the central...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28812407/scaling-the-punctum-and-canaliculus-in-patients-undergoing-punctoplasty-surgery-a-prospective-cohort-study
#4
Nisha Nesaratnam, Krisztina Emeriewen, Julie Smith, Beena David, James Wawrzynski, Anant Sharma, George M Saleh
Optical Coherence Tomography (OCT) is a safe and non-invasive method of high-resolution cross-sectional imaging of tissue microstructures using infrared radiation. This study investigates how the appearance of the punctum and proximal canaliculus differs pre- and post-operatively in patients undergoing punctoplasty surgery. Patients with symptomatic punctal stenosis warranting punctoplasty surgery were prospectively invited to enrol from a single centre. Spectral OCT images of the lower punctae were captured with a Topcon 3D OCT 2000 machine pre- and post-operatively (at their follow-up appointment)...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28805978/obeticholic-acid-a-selective-farnesoid-x-receptor-agonist-regulates-bile-acid-homeostasis-in-sandwich-cultured-human-hepatocytes
#5
Yuanyuan Zhang, Jonathan P Jackson, Robert L St Claire, Kimberly Freeman, Kenneth R Brouwer, Jeffrey E Edwards
Farnesoid X receptor (FXR) is a master regulator of bile acid homeostasis through transcriptional regulation of genes involved in bile acid synthesis and cellular membrane transport. Impairment of bile acid efflux due to cholangiopathies results in chronic cholestasis leading to abnormal elevation of intrahepatic and systemic bile acid levels. Obeticholic acid (OCA) is a potent and selective FXR agonist that is 100-fold more potent than the endogenous ligand chenodeoxycholic acid (CDCA). The effects of OCA on genes involved in bile acid homeostasis were investigated using sandwich-cultured human hepatocytes...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28766277/a-review-on-use-of-botulinum-toxin-for-intractable-lacrimal-drainage-disorders
#6
REVIEW
Swati Singh, Mohammad Javed Ali, Friedrich Paulsen
PURPOSE: To review the published literature on botulinum toxin (BTX) for epiphora secondary to refractory lacrimal drainage disorders. METHODS: The authors performed a Pub Med search of all articles published in English on BTX injection into lacrimal gland for epiphora secondary to lacrimal drainage disorders. Relevant cross-references were obtained from the resultant studies. Data reviewed included demographics, indications, dose of BTX, number of injections, transconjunctival or transcutaneous route, outcomes and complications...
August 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28766180/the-expression-of-water-channel-proteins-during-human-salivary-gland-development-a-topographic-study-of-aquaporins-1-3-and-5
#7
Fernanda de Paula, Tathyane Harumi Nakajima Teshima, Ricardo Hsieh, Milena Monteiro Souza, Claudia Malheiros Coutinho-Camillo, Marcello Menta Simonsen Nico, Silvia Vanessa Lourenco
Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages of human salivary gland morphogenesis and discuss the possible role of AQP for glandular maturation. Human salivary glands derived from foetuses aged between 14 and 25 weeks were submitted to immunohistochemistry...
August 1, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28766110/synchronous-polymorphous-adenocarcinoma-and-canalicular-adenoma-on-the-upper-lip-an-unusual-presentation-and-immunohistochemical-analysis
#8
Rose Mara Ortega, Andréia Bufalino, Luciana Yamamoto Almeida, Claudia Maria Navarro, Daphine Caxias Travassos, Túlio Morandin Ferrisse, Roman Carlos, Jorge Esquiche León
Multiple salivary gland tumors (MSGTs) are most common in the major than minor salivary glands. The most MSGTs are synchronous, either benign or malignant. A 61-year-old woman was referred presenting nine submucosal nodules, firm to fluctuant, being five nodules on the right side and four nodules on the left side of the upper lip. An incisional biopsy was performed. Hematoxylin and eosin staining was performed in 5-µm sections for histopathologic analysis. Immunohistochemical reactions were carried out in 3-µm sections in accordance with manufacturer's instructions...
August 1, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28762142/intracortical-stiffness-of-mid-diaphysis-femur-bovine-bone-lacunar-canalicular-based-homogenization-numerical-solutions-and-microhardness-measurements
#9
Ilige S Hage, Ramsey F Hamade
Microscale lacunar-canalicular (L-C) porosity is a major contributor to intracortical bone stiffness variability. In this work, such variability is investigated experimentally using micro hardness indentation tests and numerically using a homogenization scheme. Cross sectional rings of cortical bones are cut from the middle tubular part of bovine femur long bone at mid-diaphysis. A series of light microscopy images are taken along a line emanating from the cross-section center starting from the ring's interior (endosteum) ring surface toward the ring's exterior (periosteum) ring surface...
September 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28752112/lacunar-canalicular-network-in-femoral-cortical-bone-is-reduced-in-aged-women-and-is-predominantly-due-to-a-loss-of-canalicular-porosity
#10
A M Ashique, L S Hart, C D L Thomas, J G Clement, P Pivonka, Y Carter, D D Mousseau, D M L Cooper
The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed to serve as the mechanosensors that coordinate the processes of bone modeling and remodeling. Imbalances in remodeling, for example, are linked to bone disease, including fragility associated with aging. We have reported that there is a reduction in scale for one component of the LCN, osteocyte lacunar volume, across the human lifespan in females. In the present study, we explore the hypothesis that canalicular porosity also declines with age...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28730080/old-canalicular-laceration-repair-a-retrospective-study-of-the-curative-effects-and-prognostic-factors
#11
Fang Bai, Hai Tao, Yan Zhang, Peng Wang, Cui Han, Yi-Fei Huang, Ye Tao
AIM: To investigate the epidemiology and surgical outcomes of old canalicular laceration and analyze the variables impacting on the prognosis of reparation. METHODS: A retrospective review of all old canalicular laceration repairs from Jan. 1, 2008 to Dec. 30, 2015 was performed. Analyzed data included demographics, mechanisms of injury, the time from injury to repair, causes for delayed repair, old associated injuries, the types of surgery, and the effects of repair using canaliculus anastomosis combined with bicanalicular stent intubation...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723734/transcanalicular-diode-laser-assisted-revision-surgery-for-failed-dacryocystorhinostomy-with-or-without-distal-or-common-canalicular-obstruction
#12
Je Moon Yoon, Seung Wan Nam, Kyung In Woo, Yoon-Duck Kim
PURPOSE: To report the outcomes of transcanalicular diode laser-assisted revision surgery for failed dacryocystorhinostomy with/without distal or common canalicular obstruction. METHODS: The medical records and recorded videos of consecutive transcanalicular diode laser-assisted revision surgeries performed for failed dacryocystorhinostomy between May 2011 and May 2015 were reviewed. Cases of unavailability of video and cases lost to follow up after surgery were excluded from the study...
July 18, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28713897/expression-of-irak%C3%A2-3-is-associated-with-colitis%C3%A2-associated-tumorigenesis-in-mice
#13
Dingting Xu, Hanyun Zhang, Xiaoying Wang, Yan Chen
Interleukin‑1 receptor‑associated kinase‑3 (IRAK‑3) is a negative regulator in Toll‑like receptor (TLR) pathways. The present study investigated the importance of IRAK‑3 in a mouse model of chemically‑induced colitis‑associated tumorigenesis. The colitis‑associated tumorigenesis was induced in ICR mice by the administration of 1,2‑dimethyl hydrazine (DMH) and dextran sodium sulfate (DSS), termed the DMH + DSS group. In the DSS group, mice were administered with DSS; in the DMH group, mice were injected with DMH; in the control group, mice were injected with physiological saline...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28709949/pulmonary-hypoplasia
#14
REVIEW
C Michael Cotten
To survive the transition to extrauterine life, newborn infants must have lungs that provide an adequate surface area and volume to allow for gas exchange. The dynamic activities of fetal breathing movements and accumulation of lung luminal fluid are key to fetal lung development throughout the various phases of lung development and growth, first by branching morphogenesis, and later by septation. Because effective gas exchange is essential to survival, pulmonary hypoplasia is among the leading findings on autopsies of children dying in the newborn period...
July 11, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28705661/canaliculorhinostomy-indications-and-surgical-results
#15
Jung Hye Lee, Stephanie Ming Young, Yoon-Duck Kim, Kyung In Woo, Jung-Hoon Yum
PURPOSE: To report the surgical results of canaliculorhinostomy for patients with distal canalicular obstruction and lacking a structurally functional lacrimal sac who would otherwise require a conjunctivodacryocystorhinostomy(CDCR) with Jones tube placement. DESIGN: Retrospective observational case series. METHODS: • Setting: Single tertiary institution. • Period: November 1994 to June 2011. • Patient Population: 16 patients with canalicular obstruction at or beyond 8 mm from the punctum, with an absent or unidentifiable lacrimal sac...
July 10, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28702480/dataset-on-transcriptional-profiles-and-the-developmental-characteristics-of-pdgfr%C3%AE-expressing-lung-fibroblasts
#16
Mehari Endale, Shawn Ahlfeld, Erik Bao, Xiaoting Chen, Jenna Green, Zach Bess, Matthew Weirauch, Yan Xu, Anne Karina Perl
The following data are derived from key stages of acinar lung development and define the developmental role of lung interstitial fibroblasts expressing platelet-derived growth factor alpha (PDGFRα). This dataset is related to the research article entitled "Temporal, spatial, and phenotypical changes of PDGFRα expressing fibroblasts during late lung development" (Endale et al., 2017) [1]. At E16.5 (canalicular), E18.5 (saccular), P7 (early alveolar) and P28 (late alveolar), PDGFRα(GFP) mice, in conjunction with immunohistochemical markers, were utilized to define the spatiotemporal relationship of PDGFRα(+) fibroblasts to endothelial, stromal and epithelial cells in both the proximal and distal acinar lung...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28696161/comparison-of-normal-facial-nerve-enhancement-at-3t-mri-using-gadobutrol-and-gadopentetate-dimeglumine
#17
Rupa Radhakrishnan, Shamima Ahmed, Joshua Cole Tilden, Humberto Morales
Background and purpose The facial nerve is unique among cranial nerves in demonstrating normal enhancement of particular segments. The effect of varying T1 relaxivities of gadolinium-based contrast agents on facial nerve enhancement is unclear. In this study, we assess differences in normal facial nerve enhancement with two different gadolinium-based contrast agents, gadobutrol and gadopentetate dimeglumine. In addition, we evaluate differences in facial nerve enhancement with spin-echo (SE) T1 versus 3D inversion recovery prepared fast spoiled gradient-echo (FSPGR) post-contrast sequences...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28683481/-recanalization-of-lacrimal-duct-stenosis-by-laserdacryoplasty-using-a-diode-laser-comparison-of-success-rates-using-an-erbium%C3%A2-%C3%A2-yag-laser
#18
Ludwig Stock, Ralf Ungerechts, Karl-Heinz Emmerich
Background In a retrospective study, the success rates of laserdacryoplasty using a diode laser were defined and compared to success rates using an erbium : YAG laser. Using a diode laser at a wave length of 980 nm, thermal destruction of tissue leads to recanalization. Using an erbium : YAG laser at a wave length of 2940 nm, recanalization of punctual stenosis is achieved by formation of a cavitation bubble in a closed system. Materials and Methods 94 patients (64 women, 30 men, mean age 60.8 years) with 107 absolute lacrimal duct stenoses who were treated by laserdacryoplasty using a diode laser were included in a retrospective study...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28666969/vitamin-d-regulates-osteocyte-survival-and-perilacunar-remodeling-in-human-and-murine-bone
#19
Tim Rolvien, Matthias Krause, Anke Jeschke, Timur Yorgan, Klaus Püschel, Thorsten Schinke, Björn Busse, Marie B Demay, Michael Amling
Osteocytes are the most abundant bone cells and are highly regulated by external stimuli. Vitamin D and osteocytes cooperatively regulate bone remodeling as well as phosphate and calcium homeostasis. However, it is unclear if vitamin D regulates osteocyte number, connectivity or size in the setting of altered bone formation or impaired mineralization. Sixty iliac crest biopsies of patients with varying vitamin D levels were examined to analyze osteocyte number, osteocyte connectivity and osteocyte viability using high-resolution imaging...
June 27, 2017: Bone
https://www.readbyqxmd.com/read/28666032/pulmonary-vascular-changes-in-extremely-preterm-sheep-after-intra-amniotic-exposure-to-ureaplasma-parvum-and-lipopolysaccharide
#20
Monique G M Willems, Matthew W Kemp, Laura A Fast, Nick M M Wagemaker, Leon E W Janssen, John P Newnham, Matt S Payne, Owen B Spiller, Suhas G Kallapur, Alan H Jobe, Tammo Delhaas, Boris W Kramer, Tim G A M Wolfs
BACKGROUND: Chorioamnionitis can induce pulmonary inflammation and promote bronchopulmonary dysplasia development, distinguished by alveolar simplification and impaired vascular growth. Chorioamnionitis is more common during the extremely preterm canalicular lung stage (crucial for vascular development); and increases the risk for subsequent sepsis. We hypothesized that single/combined exposure to chronic and/or acute inflammation induces pulmonary inflammatory responses and vascular changes...
2017: PloS One
keyword
keyword
28494
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"