keyword
MENU ▼
Read by QxMD icon Read
search

canalicular

keyword
https://www.readbyqxmd.com/read/29053675/transcanalicular-diode-laser-assisted-dacryocystorhinostomy-for-the-treatment-of-primary-acquired-nasolacrimal-duct-obstruction
#1
Joel M Mor, Yongwei Guo, Konrad R Koch, Ludwig M Heindl
Today's gold standard in the treatment of infrasaccal primary acquired nasolacrimal duct obstruction (PANDO) is external dacryocystorhinostomy (DCR), a relatively invasive procedure that can be performed after failure of recanalizing treatments. However, with progress in the field of diode laser technology, new approaches have emerged. Laser-assisted transcanalicular DCR with subsequent bicanalicular silicon intubation is a new option showing great promise as a viable minimally invasive procedure. Under permanent endoscopic visual control from the nasal cavity, a diode laser fiber is inserted into the lacrimal sac and laser energy is applied to create a bony ostium between the lacrimal sac and the nasal cavity...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#2
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28990978/bicanalicular-canaliculops-and-its-dacryoendoscopic-findings
#3
Alice Venyir Ramyil, Shweta Gupta, Mohammad Javed Ali, Milind N Naik
Canaliculops is a noninflammatory ectasia of the canaliculus and so far only 7 histopathologically confirmed cases have been reported worldwide. The authors present a middle aged female with right-sided bicanalicular cystic swellings associated with punctal agenesis. Ultrasound biomicroscopy showed a cystic dilatation of the canaliculus and dacryoendoscopy showed a cavity lined by whitish canalicular mucosa, thrown into numerous irregular folds with a blind medial end. Histopathological examination confirmed the diagnosis of canaliculops...
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28974876/laparoscopy-in-the-evaluation-of-impalpable-testes-and-its-short-term-outcomes-a-7-years-experience
#4
Rajarshi Kumar, Kartik Chandra Mandal, Pankaj Halder, Md Hadiuzzaman, Madhumita Mukhopadhyay, Biswanath Mukhopadhyay
AIMS: The aim of this study is to report and analyze results of laparoscopy in impalpable testes performed between 2009 and 2016 and its short-term outcomes. MATERIALS AND METHODS: Demographic data, laterality, laparoscopic findings, operative time, procedure, hospital stay, complications, and follow-up data of 76 patients with 79 impalpable testes from 2009 to 2016 were retrospectively collected and analyzed. Successful outcome was defined as maintenance of intrascrotal position with no atrophy at a follow-up of at least 6 months...
October 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28973556/clofibrate-decreases-bile-acids-in-livers-of-male-mice-by-increasing-biliary-bile-acid-excretion-in-a-ppar%C3%AE-dependent-manner
#5
Youcai Zhang, Andrew J Lickteig, Iván L Csanaky, Curtis D Klaassen
Fibrates and their receptor, namely peroxisome proliferator-activated receptor α (PPARα), have been reported to regulate bile acid (BA) synthesis and transport. However, the effect of fibrate treatment and PPARα activation on BA homeostasis remains controversial. In the present study, both wild-type (WT) and PPARα-null male mice were treated with clofibrate (CLOF) for 4 days to evaluate the effects of short-term PPARα activation on bile acid (BA) homeostasis. While a decrease in total BAs was observed in livers of CLOF-treated WT mice, it was not observed in PPARα-null mice...
September 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28971977/human-lung-branching-morphogenesis-is-orchestrated-by-the-spatio-temporal-distribution-of-acta2-sox2-and-sox9
#6
Soula Danopoulos, Irving Alonso, Matthew Thornton, Brendan Grubbs, Saverio Bellusci, David Warburton, Denise Al Alam
Lung morphogenesis relies on a number of important processes including proximal-distal patterning, cell proliferation, migration and differentiation, as well as epithelial-mesenchymal interactions. In mouse lung development, SOX2+ cells are localized in the proximal epithelium whereas SOX9+ cells are present in the distal epithelium. We show that in human lung, expression of these transcription factors differs, in that during the pseudoglandular stage distal epithelial progenitors at the tips co-express SOX2 and SOX9...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28971976/recent-advances-in-our-understanding-of-the-mechanisms-of-late-lung-development-and-bronchopulmonary-dysplasia
#7
David Emanuel Surate Solaligue, José Alberto Rodríguez-Castillo, Katrin Ahlbrecht, Rory E Morty
The objective of lung development is to generate an organ of gas exchange that provides both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly generates a steep gas-diffusion concentration gradient. As such, the lung is perfectly structured to undertake the function of gas exchange: a large number of small alveoli provide extensive surface area within the limited volume of the lung, and a delicate alveolo-capillary barrier brings circulating blood into close proximity to the inspired air...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28945205/post-transplant-recurrent-bile-salt-export-pump-disease-a-form-of-antibody-mediated-graft-dysfunction-and-utilization-of-c4d
#8
Kalyani R Patel, Sanjiv Harpavat, Milton Finegold, Karen Eldin, John Hicks, Mihail Firan, Verena Keitel, Ralf Kubitz, Hao Wu
Recurrent bile salt export pump (rBSEP) disease has been reported in progressive familial intrahepatic cholestasis type 2 (PFIC2) patients following liver transplantation (LT) and is often refractory to standard anti-cellular rejection immunosuppressants. The mechanism of rBSEP disease is proposed to be a form of type II hypersensitivity reaction with de novo anti-BSEP antibodies blocking the function of allograft BSEP. Utilization of C4d has not been evaluated in rBSEP. We describe a girl with 3 episodes of rBSEP with severe pruritus at 8...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937434/th17-response-of-borderline-lepromatous-leprosy-inhibits-rash-manifestation-of-dapsone-hypersensitivity-syndrome-case-report
#9
Tamara de Nardo Vanzela, Fred Bernardes Filho, Carlos Gustavo Wambier, Francesca Maia Faria, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. OBJECTIVE: Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. METHODS: The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28929774/canalicular-cholestasis-induced-by-anabolic-steroids
#10
María Del Pilar Silva Ruiz, Álvaro Giráldez Gallego, María Serrano Jiménez
Inappropriate use of anabolic steroids is increasing, usually by younger males in an illicit manner. This is a well-documented case of cholestatic hepatitis attributed to use of anabolic steroids for esthetic and/or athletic purposes.
October 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28913995/intraoperatively-observed-lacrimal-obstructive-features-and-surgical-outcomes-in-external-dacryocystorhinostomy
#11
Min Joung Lee, Sang In Khwarg, In Hyuk Kim, Jeong Hoon Choi, Youn Joo Choi, Namju Kim, Ho Kyung Choung
PURPOSE: To analyze the features of lacrimal drainage system obstruction confirmed during external dacryocystorhinostomy surgeries and report the surgical outcomes. METHODS: We reviewed the medical records of a total of 769 cases who underwent external dacryocystorhinostomy for primary lacrimal drainage obstruction between 2005 and 2014. Data about detailed location and extent of obstruction were collected intraoperatively. The sites of obstruction were classified into nasolacrimal duct obstruction (NLDO), common canalicular obstruction (CCO), and canalicular obstruction...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28890252/canalicular-adenoma-a-systematic-review
#12
Alberto J Peraza, John Wright, Ruth Gómez
OBJECTIVE: Canalicular adenoma (CA) is an uncommon but unique benign tumor of salivary gland origin. It is the third most common benign tumor of minor salivary glands, representing less than 1% of all salivary neoplasms. A systematic review is presented of reported cases of CA, to determine trends in presentation, diagnostic features, treatment, and patient outcome. METHODS: Searches of specific databases, as reported, were carried out to identify papers reporting CA...
October 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28888833/iron-depletion-induces-hepatic-secretion-of-biliary-lipids-and-glutathione-in-rats
#13
Alena Prasnicka, Jolana Cermanova, Milos Hroch, Eva Dolezelova, Lucie Rozkydalova, Tomas Smutny, Alejandro Carazo, Jaroslav Chladek, Martin Lenicek, Petr Nachtigal, Libor Vitek, Petr Pavek, Stanislav Micuda
Iron depletion (ID) has been shown to induce the liver expression of Cyp7a1, the rate-limiting enzyme initiating conversion of cholesterol to bile acids (BA), although the effect on bile acids metabolism and bile production is unknown. Therefore, we investigated changes in bile secretion and BA synthesis during diet-induced iron depletion (ID) in rats. ID increased bile flow along with augmented biliary excretion of bile acids, glutathione, cholesterol and phospholipids. Accordingly, we found transcriptional upregulation of the Cyp7a1, Cyp8b1, and Cyp27a1 BA synthetic enzymes, as well as induction of the Abcg5/8 cholesterol transporters in ID rat livers...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28888391/osteocytes-and-the-bone-lacunar-canalicular-system-insights-into-bone-biology-and-skeletal-function-using-bone-tissue-microstructure
#14
REVIEW
Russell P Main
No abstract text is available yet for this article.
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28887638/a-new-strategy-to-sustained-release-of-ocular-drugs-by-one-step-drug-loaded-microcapsule-manufacturing-in-hydrogel-punctal-plugs
#15
Jiajun Xie, Changjun Wang, Qingyao Ning, Qi Gao, Changyou Gao, Zhongru Gou, Juan Ye
PURPOSE: To design an injectable hyaluronate (HA)-based hydrogel system that contains drug-loaded microcapsules as resorbable plugs to deliver ocular drugs. METHODS: In-situ drug-loaded, core-shell-structured chitosan (CS)@HA microcapsules were fabricated via HA hydrosol collecting in electrospun bead-rich CS fibers under continuous stirring. An injectable and cytocompatible hydrogel system with different degrees of chemical crosslinking maintained viscoelastic and sustained drug release for a long-term period of time at body temperature in vitro...
November 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28860909/anatomical-and-functional-outcomes-of-canalicular-laceration-repair-with-self-retaining-mini-monoka-stent
#16
Md Shahid Alam, Neha Shrirao Mehta, Bipasha Mukherjee
AIM: To evaluate the anatomical and functional outcomes of canalicular laceration repair with self retaining monocanalicular intubation system (Mini-MONOKA). MATERIALS AND METHODS: The data of 29 patients undergoing canalicular laceration repair from 2010 to 2014 were retrospectively analyzed. Operative details and complications were noted. The stent was removed earliest at 3 months. Anatomical and functional success was defined by a patent syringing and the absence of epiphora respectively...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28860195/hypothyroidism-induced-by-loss-of-the-manganese-efflux-transporter-slc30a10-may-be-explained-by-reduced-thyroxine-production
#17
Chunyi Liu, Steven Hutchens, Thomas Jursa, William Shawlot, Elena V Polishchuk, Roman S Polishchuk, Beth K Dray, Andrea C Gore, Michael Aschner, Donald R Smith, Somshuvra Mukhopadhyay
SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-of-function mutations in genes encoding either transporter induce hereditary manganese toxicity. Patients have elevated manganese in the blood and brain and develop neurotoxicity. Liver manganese is increased in patients lacking SLC30A10 but not SLC39A14. These organ-specific changes in manganese were recently recapitulated in knockout mice. Surprisingly, Slc30a10 knockouts also had elevated thyroid manganese and developed hypothyroidism...
October 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28844640/early-versus-late-canalicular-laceration-repair-outcomes
#18
Yen-Chang Chu, Shu-Ya Wu, Yueh-Ju Tsai, Yi-Lin Liao, Hsueh-Yen Chu
PURPOSE: To determine whether delayed repair of traumatic canalicular laceration affects the final outcome. DESIGN: Retrospective case series. METHODS: The medical records of 334 patients who underwent primary traumatic canalicular laceration repair were retrospectively reviewed. Patients were divided into 2 groups according to the surgical timing within 48 hours (early) or after 48 hours (delayed). The anatomic results were compared between these 2 groups...
October 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28839429/partial-external-biliary-diversion-in-bile-salt-export-pump-deficiency-association-between-outcome-and-mutation
#19
Philipp Ellinger, Jan Stindt, Carola Dröge, Katharina Sattler, Claudia Stross, Stefanie Kluge, Diran Herebian, Sander H J Smits, Martin Burdelski, Sebastian Schulz-Jürgensen, Antje Ballauff, Jan Schulte Am Esch, Ertan Mayatepek, Dieter Häussinger, Ralf Kubitz, Lutz Schmitt
AIM: To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency. METHODS: Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28838453/cholestasis-after-pediatric-liver-transplantation-recurrence-of-a-progressive-familial-intrahepatic-cholestasis-phenotype-as-a-rare-differential-diagnosis-a-case-report
#20
B Prusinskas, S Kathemann, D Pilic, B Hegen, P Küster, V Keitel, D Häussinger, R Büscher, H A Baba, P F Hoyer, E Lainka
INTRODUCTION: Nonobstructive cholestasis after pediatric liver transplantation is a common diagnostic and therapeutic dilemma. We describe a girl with neonatal cholestasis because of progressive familial intrahepatic cholestasis 2 (PFIC-2) and presence of a homozygous splice site mutation in the ABCB11 gene. Liver transplantation was performed because of end-stage liver disease at the age of 6. Cholestasis with normal gamma-glutamyl transferase (GGT) developed 8 years after liver transplantation...
September 2017: Transplantation Proceedings
keyword
keyword
28494
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"