Carlos A Vergani-Junior, Raíssa De P Moro, Silas Pinto, Evandro A De-Souza, Henrique Camara, Deisi L Braga, Guilherme Tonon-da-Silva, Thiago L Knittel, Gabriel P Ruiz, Raissa G Ludwig, Katlin B Massirer, William B Mair, Marcelo A Mori
Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We show that upregulation of ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants)...
April 9, 2024: Nature Communications