keyword
Keywords chemotherapy induced periphera...

chemotherapy induced peripheral neuropathy

https://read.qxmd.com/read/38530364/satellite-glial-gpr37l1-and-its-ligand-maresin-1-regulate-potassium-channel-signaling-and-pain-homeostasis
#1
JOURNAL ARTICLE
Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji
G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs), selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane expression in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38515579/risk-factors-of-paclitaxel-induced-peripheral-neuropathy-in-patients-with-breast-cancer-a-prospective-cohort-study
#2
JOURNAL ARTICLE
Sun Lixian, Yu Xiaoqian, Guo Luyan, Zhou Lizhi, Du Rui, Yao Hongyue, Zhao Caijie, Yuan Fenghui
OBJECTIVE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse reaction in taxane-based chemotherapy. This study aimed to analyze the risk factors of peripheral neuropathy in patients with breast cancer receiving paclitaxel chemotherapy to provide a reference for the early prevention of CIPN. METHODS: We included 350 patients with breast cancer who received chemotherapy for the first time at the Tangshan People's Hospital between August 2022 and June 2023 and were followed for at least 3 months after the end of chemotherapy...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515446/corrigendum-exercise-for-reducing-chemotherapy-induced-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
Yingjie Huang, Tian Tan, Lu Liu, Zijian Yan, Yuexia Deng, Guangyao Li, Min Li, Jia Xiong
[This corrects the article DOI: 10.3389/fneur.2023.1252259.].
2024: Frontiers in Neurology
https://read.qxmd.com/read/38511878/rate-and-characteristics-of-inflammatory-neuropathies-associated-with-brentuximab-vedotin-therapy
#4
JOURNAL ARTICLE
Arthur Matthys, Benjamin Bardel, Fabien Le Bras, Alain Créange, Tarik Nordine, Romain Gounot, Saskia Ingen-Housz-Oro, Muriel Carvalho, Jean-Pascal Lefaucheur, Corinne Haioun, Violaine Planté-Bordeneuve, Thierry Gendre
BACKGROUND AND PURPOSE: Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV-induced neuropathy (BV-CN) is a mild distal sensory axonal polyneuropathy. Severe BV-induced inflammatory neuropathies (BV-IN) have been described. BV-IN contribute to lymphoma-associated morbidity but might be immunotherapy-responsive. Our primary objective was to evaluate the rate of BV-IN. Our secondary objectives were to determine risk factors and warning signs...
March 21, 2024: European Journal of Neurology
https://read.qxmd.com/read/38506220/asymmetric-carbene-alkyne-metathesis-mediated-cascade-synthesis-of-benzoxazine-polychiral-polyheterocycles-and-discovery-of-a-novel-pain-blocker
#5
JOURNAL ARTICLE
Shuhao Liu, Haoyi Yang, Jirong Shu, Linna Wu, Yukai Li, Zhijing Zhang, Weijie Guo, Shuxian Cai, Fuyi Li, Wenjiang Liu, Shikun Jia, Song Cai, Taoda Shi, Wenhao Hu
This study introduces a novel approach for synthesizing Benzoxazine-Centered Polychiral Polyheterocycles (BPCPHCs) via an innovative asymmetric carbene-alkyne metathesis-triggered cascade. Overcoming challenges associated with intricate stereochemistry and multiple chiral centers, the catalytic asymmetric Carbene Alkyne Metathesis-mediated Cascade (CAMC) is employed using dirhodium catalyst/Brønsted acid co-catalysis, ensuring precise stereo control as validated by X-ray crystallography. Systematic substrate scope evaluation establishes exceptional diastereo- and enantioselectivities, creating a unique library of BPCPHCs...
March 20, 2024: Angewandte Chemie
https://read.qxmd.com/read/38504152/paclitaxel-induced-acute-myocardial-infarction-a-case-report-and-literature-review
#6
JOURNAL ARTICLE
Gi Eun Kim, Ayman R Ibrahim, Duha Shalatouni, Nadin H Abouzeid, Fahmi Othman
BACKGROUND: Paclitaxel is a chemotherapeutic agent commonly used for ovarian, lung, breast carcinoma, and Kaposi's sarcoma. Its common side effects include hypersensitivity reaction, bone marrow suppression, and peripheral neuropathy. However, a rare and life-threatening side effect is paclitaxel-induced myocardial infarction. CASE PRESENTATION: A 71-year-old man with type 2 diabetes mellitus, hypertension, heavy smoking history, previous coronary artery disease with percutaneous coronary intervention (PCI) in left anterior descending artery (LAD), and non-small lung cancer presented with non-ST elevation myocardial infarction during infusion of paclitaxel infusion...
March 19, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38502556/conservative-non-pharmacological-treatments-for-chemotherapy-induced-peripheral-neuropathies-in-women-treated-for-breast-cancer-a-systematic-review
#7
JOURNAL ARTICLE
Gianpaolo Ronconi, Dario M Gatto, Sefora Codazza, Mariantonietta Ariani, Eloisa Martire, Luca Cerretti, Valentina Carella, Daniele Coraci, Giorgio Ferriero, Paola E Ferrara
INTRODUCTION: Over the last few decades, the use of neo/adjuvant therapies has significantly increased the number of breast cancer survivors who experience chemotherapy-induced peripheral neuropathy (CIPN). To date, few, low-efficacy, pharmacological remedies exist to manage this side effect. For this reason, alternative treatments are increasingly being investigated as possible strategies to prevent or promote faster recovery from CIPN. In this review we aimed to provide an overview of the literature evidence regarding all the non-pharmacological and rehabilitative interventions for patients affected by CIPN secondary to breast cancer care...
March 19, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38496640/cannabinoid-cb-2-receptors-in-primary-sensory-neurons-are-implicated-in-cb-2-agonist-mediated-suppression-of-paclitaxel-induced-neuropathic-nociception-and-sexually-dimorphic-sparing-of-morphine-tolerance
#8
Kelsey G Guenther, Xiaoyan Lin, Zhili Xu, Alexandros Makriyannis, Julian Romero, Cecilia J Hillard, Ken Mackie, Andrea G Hohmann
Cannabinoid CB 2 agonists show therapeutic efficacy without the unwanted side effects commonly associated with direct activation of CB 1 receptors. The G protein-biased CB 2 receptor agonist LY2828360 attenuates the maintenance of chemotherapy-induced neuropathic nociception in male mice and blocks the development of morphine tolerance in this model. However, the specific cell types involved in this phenomenon have never been investigated and whether this therapeutic profile is observed in female mice remains poorly understood...
March 10, 2024: bioRxiv
https://read.qxmd.com/read/38481688/characterization-of-a-nonselective-opioid-receptor-functional-antagonist-implications-for-development-as-a-novel-opioid-dependence-medication
#9
JOURNAL ARTICLE
Siavash Shahbazi Nia, Yuma T Ortiz, Julio D Zuarth Gonzalez, Leila Shamir, Kofi Frimpong-Manson, Mohammad Anwar Hossain, Sadisna Shahi, Rayna Bandy, Anoushka Bhat, Dhavalkumar Patel, Hanin Diab, Jonathan Thompson, Lance R McMahon, Jenny L Wilkerson, Nadezhda A German
Opioids represent the most extensive category of abused substances in the United States, and the number of fatalities caused by these drugs exceeds those associated with all other drug overdoses combined. The administration of naltrexone, a potent pan-opioid receptor antagonist, to an individual dependent on opioids can trigger opioid withdrawal and induce severe side effects. There is a pressing demand for opioid antagonists free of opioid withdrawal effects. In our laboratory, we have identified a compound with affinity to mu, delta, and kappa opioid receptors in the range of 150-250 nM...
March 8, 2024: ACS Pharmacology & Translational Science
https://read.qxmd.com/read/38481526/feasibility-and-tolerability-of-eribulin-based-chemotherapy-versus-other-chemotherapy-regimens-for-patients-with-metastatic-triple-negative-breast-cancer-a-single-centre-retrospective-study
#10
JOURNAL ARTICLE
Weiwei Huang, Chenxi Wang, Lili Wang, Yangkun Shen, Qi Chen, Zhijian Huang, Jian Liu, Xiaoyan Lin, Fan Wu, Xinhua Chen, Nani Li, Yi Hong, Mulan Chen, Jieyu Li, Chuanzhong Huang
Background: Patients with Triple-negative breast cancer (TNBC) face a poor prognosis and limited therapeutic options. Current data on eribulin usage to treat TNBC is scarce. Therefore, we sought to compare the feasibility and tolerability of eribulin-based regimens with other chemotherapy regimens in patients with TNBC. Method: This retrospective study was conducted at Fujian Medical University Cancer Hospital and included 159 patients with TNBC enrolled between October 2011 and January 2023. Patients underwent treatment with eribulin-based and other chemotherapy regimens...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38479571/sonic-hedgehog-restrains-the-ubiquitin-dependent-degradation-of-sp1-to-inhibit-neuronal-glial-senescence-associated-phenotypes-in-chemotherapy-induced-peripheral-neuropathy-via-the-trim25-cxcl13-axis
#11
JOURNAL ARTICLE
Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. However, the current treatment options for CIPN are limited. Paclitaxel (PTX) is a widely used chemotherapeutic drug that induces senescence in cancer cells. While previous studies have demonstrated that Sonic hedgehog (Shh) can counteract cellular dysfunction during aging, its role in CIPN remains unknown. OBJECTIVES: Herein, the aim of this study was to investigate whether Shh activation could inhibits neuronal/glial senescence and alleviates CIPN...
March 11, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38469410/neuropredict-study-of-the-predictive-value-of-abcb1-genetic-polymorphisms-and-associated-clinical-factors-in-chronic-chemotherapy-induced-peripheral-neuropathy-cipn
#12
JOURNAL ARTICLE
Alicia Vargas-Aliaga, María De la Haba, María José Contreras, Cristina Morales Estevez, Ignacio Porras, María Teresa Cano, Gema Pulido, María Auxiliadora Gómez, Pablo Flores-Paco, De La Haba-Rodriguez Juan, Enrique Aranda
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common entity (30%-40%) and can significantly limit the quality of life of patients, especially those that persist for more than 6 months after treatment (chronic neuropathy). Studies have shown a possible association between the presence of genetic polymorphisms in ABCB1 and the development of acute CIPN, although this relationship with chronic CIPN remains unexplored. This is an analytical observational case-control study defined by the presence (cases) or absence (controls) of CIPN at 6 months after the end of the neurotoxic drug...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38464172/the-primary-cilium-and-its-hedgehog-signaling-in-nociceptors-contribute-to-inflammatory-and-neuropathic-pain
#13
Kerry Tucker, Lindsey Fitzsimons, Larissa Staurengo-Ferrari, Oliver Bogen, Dioneia Araldi, Ivan Bonet, Ethan Jordan, Jon Levine
The primary cilium, a 1-3 μm long hair-like structure protruding from the surface of almost all cells in the vertebrate body, is critical for neuronal development and also functions in the adult. As the migratory neural crest settles into dorsal root ganglia (DRG) sensory neurons elaborate a single primary cilium at their soma that is maintained into adult stages. While it is not known if primary cilia are expressed in nociceptors, or their potential function in the mature DRG neuron, recent studies have shown a role for Hedgehog, whose signaling demonstrates a dependence on primary cilia, in nociceptor sensitization...
February 26, 2024: Research Square
https://read.qxmd.com/read/38464007/knockdown-sirna-targeting-gpr55-reveals-significant-differences-between-the-anti-inflammatory-actions-of-kls-13019-and-cannabidiol
#14
Douglas E Brenneman, William A Kinney, Mark E McDonnell, Michael J Ippolito, Sara Jane Ward
KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, NLRP3 and IL-1b) of dorsal root ganglion (DRG) cultures were shown to be reversed by KLS-13019 treatment. The mechanism of action for KLS-13019-mediated reversal of paclitaxel-induced neuroinflammation now has been explored using GPR55 siRNA. Pretreatment of DRG cultures with GPR55 siRNA produced a 21% decrease of immunoreactive (IR) area for GPR55 in cell bodies and a 59% decrease in neuritic IR area, as determined by high content imaging...
February 28, 2024: Research Square
https://read.qxmd.com/read/38461728/acute-long-term-or-non-vincristine-induced-peripheral-neuropathy-among-non-hodgkin-lymphoma-survivors-symptoms-daily-activities-functional-status-and-quality-of-life
#15
JOURNAL ARTICLE
Yu-Chen Su, Yeur-Hur Lai, Sung-Tsang Hsieh, Chieh-Lin Jerry Teng, Yun-Hsiang Lee
PURPOSE: This study aimed to explore the incidence and severity of vincristine-induced peripheral neuropathy (VIPN) in non-Hodgkin lymphoma (NHL) survivors (primary aim) and its impact on daily life by comparing common cancer symptoms, functional status, and quality of life (QoL) among survivors with acute, long-term, and non-VIPN (secondary aim). METHODS: This cross-sectional study examined 144 NHL survivors. Standardized questionnaires were used to assess common cancer symptoms, functional status, and QoL with the European Organization for the Research and Treatment of Cancer - Quality of Life Questionnaire (EORTC-QLQ-C30)...
February 28, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38453739/a-prospective-comparison-study-utilizing-patient-reported-outcomes-of-taxane-related-peripheral-neuropathy-between-nab-paclitaxel-and-standard-paclitaxel-in-patients-with-breast-cancer
#16
JOURNAL ARTICLE
Kumiko Kida, Akimitsu Yamada, Kazuhiro Shimada, Kazutaka Narui, Sadatoshi Sugae, Daisuke Shimizu, Takako Doi, Mari Oba, Itaru Endo, Takashi Ishikawa
UNLABELLED: BACKGROUND: Characteristics of taxane-induced peripheral neuropathy (PN) could be different between paclitaxel and nab-paclitaxel. The purpose of this prospective observational multicenter cohort study was to compare tri-weekly nab-paclitaxel to weekly standard paclitaxel regarding the severity, onset and recovery of sensory and motor PN in patients with breast cancer. METHODS: Patients with histologically confirmed breast cancer who were scheduled to receive standard weekly paclitaxel (80 mg/m2 ) or tri-weekly nab-paclitaxel (260 mg/m2 ) at institutions in our multicenter group were eligible for this study...
March 8, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38447953/nav1-8-in-small-dorsal-root-ganglion-neurons-contributes-to-vincristine-induced-mechanical-allodynia
#17
JOURNAL ARTICLE
Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj
Vincristine-induced peripheral neuropathy (VIPN) is a common side effect of vincristine treatment, which is accompanied by pain and can be dose-limiting. The molecular mechanisms that underlie vincristine-induced pain are not well understood. We have established an animal model to investigate pathophysiological mechanisms of vincristine induced pain. Our previous studies have shown that the tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel NaV1.6 in medium-diameter dorsal root ganglion (DRG) neurons contributes to the maintenance of vincristine-induced allodynia...
March 6, 2024: Brain
https://read.qxmd.com/read/38445956/phytic-acid-maintains-peripheral-neuron-integrity-and-enhances-survivability-against-platinum-induced-degeneration-via-reducing-reactive-oxygen-species-and-enhancing-mitochondrial-membrane-potential
#18
JOURNAL ARTICLE
Arjun Prasad Tiwari, Bayne Albin, Khayzaran Qubbaj, Prashant Adhikari, In Hong Yang
Phytic acid (PA) has been reported to possess anti-inflammatory and antioxidant properties that are critical for neuroprotection in neuronal disorders. This raises the question of whether PA can effectively protect sensory neurons against chemotherapy-induced peripheral neuropathy (CIPN). Peripheral neuropathy is a dose-limiting side effect of chemotherapy treatment often characterized by severe and abnormal pain in hands and feet resulting from peripheral nerve degeneration. Currently, there are no effective treatments available that can prevent or cure peripheral neuropathies other than symptomatic management...
March 6, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38437959/ursolic-acid-alleviates-paclitaxel-induced-peripheral-neuropathy-through-ppar%C3%AE-activation
#19
JOURNAL ARTICLE
Yulian Yang, Zhongzheng He, Shuangchan Wu
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) reduces the overall quality of life and leads to interruption of chemotherapy. Ursolic acid, a triterpenoid naturally which presents in fruit peels and in many herbs and spices, can function as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and has been widely used as an herbal medicine with a wide spectrum of pharmacological activities, including anti-cancer, anti-inflammatory and neuroprotective effect...
March 2, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38428887/efficacy-of-the-traditional-chinese-medicine-buyang-huanwu-decoction-at-preventing-taxane-induced-peripheral-neuropathy-in-breast-cancer-patients-a-prospective-randomized-controlled-study
#20
JOURNAL ARTICLE
Fan Luo, Donggui Wan, Jun Liu, Dongmei Chen, Mengqi Yuan, Chenyang Zhang, Qing Liu
BACKGROUND: Buyang Huanwu Decoction (BYHWD) is a traditional Chinese prescription, originally derived from Yi Lin Gai Cuo during the Qing Dynasty. This study aimed to evaluate the efficacy and safety of BYHWD in the prevention of taxane-induced peripheral neuropathy (TIPN) in patients with breast cancer. METHODS: This single-center, statistician-blinded, parallel-group, simple randomized, no-treatment controlled study was conducted at the China-Japan Friendship Hospital in Beijing...
March 1, 2024: Medicine (Baltimore)
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