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Ahmed Alfares, Taghrid Aloraini, Lamia Al Subaie, Abdulelah Alissa, Ahmed Al Qudsi, Ahmed Alahmad, Fuad Al Mutairi, Abdulrahman Alswaid, Ali Alothaim, Wafaa Eyaid, Mohammed Albalwi, Saeed Alturki, Majid Alfadhel
PurposeWhole-exome sequencing (WES) and whole-genome sequencing (WGS) are used to diagnose genetic and inherited disorders. However, few studies comparing the detection rates of WES and WGS in clinical settings have been performed.MethodsVariant call format files were generated and raw data analysis was performed in cases in which the final molecular results showed discrepancies. We classified the possible explanations for the discrepancies into three categories: the time interval between the two tests, the technical limitations of WES, and the impact of the sequencing system type...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Juliana F Roos, Mariam Qudsi, Arwa Samara, Madina M Rahim, Samar A Al-Bayedh, Hafez Ahmed
Diabetes mellitus has been associated with increased risk for the development of many types of cancer. Metformin, an oral medication and first-line treatment for type 2 diabetes mellitus, has been suggested to reduce cancer risk and mortality in various types of cancer. This study focuses on assessing metformin association with lung cancer as reported in the literature. Recent studies and reviews investigating metformin effects on lung cancer incidence and patient survival are critically and systematically discussed...
February 23, 2018: European Journal of Cancer Prevention
Prashant V Rajan, Rameez A Qudsi, George S M Dyer, Elena Losina
BACKGROUND: There is no consensus on the optimal fixation method for patients who require a surgical procedure for distal radial fractures. We used cost-effectiveness analyses to determine which of 3 modalities offers the best value: closed reduction and percutaneous pinning, open reduction and internal fixation, or external fixation. METHODS: We developed a Markov model that projected short-term and long-term health benefits and costs in patients undergoing a surgical procedure for a distal radial fracture...
February 7, 2018: Journal of Bone and Joint Surgery. American Volume
Miguel Angel Sánchez-Carrasco, Juan Francisco Abellán, Salima Qudsi-Sinclair, Guadalupe Ruiz-Merino, Francisco Javier Carrillo-Juliá, David Bo-Rueda
BACKGROUND: Tear of the anterior cruciate ligament (ACL) is a common ligamentous injury of the knee. Reconstruction of this ligament is often required to restore functional stability of the knee. Outcome of ACL reconstruction is significantly affected by how the graft is fixed to the bone. This study is to determine if there is a different clinical outcome after cortical versus cortical-cancellous suspension femoral fixation in hamstring based anterior cruciate ligament (ACL) reconstruction...
September 2017: Indian Journal of Orthopaedics
Elizabeth B Gausden, Rameez Qudsi, Myles D Boone, Brian OʼGara, Joseph J Ruzbarsky, Dean G Lorich
AIM: To systematically review and quantify the efficacy of tranexamic acid (TXA) use in reducing the risk of receiving a blood transfusion in patients undergoing orthopaedic trauma surgery, in reducing blood loss, and risk of thromboembolic events. METHODS: A systematic literature search was performed using MEDLINE, Embase,, and conference proceeding abstracts from 2014 to 2016. A minimum of 2 reviewers screened each study and graded quality. The primary outcome measure was the risk of receiving a blood transfusion in the TXA group versus control...
October 2017: Journal of Orthopaedic Trauma
Rameez A Qudsi, Heather J Roberts, Abhiram R Bhashyam, Elena Losina, Donald S Bae, Francel Alexis, George S Dyer
OBJECTIVE: The burden of musculoskeletal disease remains high in low-income countries, with a high rate of pediatric disease. Efforts continue for orthopedic education, but there is little guidance on local needs and desires. Our aim was to determine the specific content and modalities that would be most useful for pediatric orthopedic educational programs abroad, and we demonstrate a practical method of identifying country-specific educational deficits through a self-reported needs survey in Haiti...
January 2018: Journal of Surgical Education
Prashant V Rajan, Rameez A Qudsi, Lindsey L Wolf, Elena Losina
No abstract text is available yet for this article.
July 5, 2017: Journal of Bone and Joint Surgery. American Volume
Abhiram R Bhashyam, Catherine Logan, Heather J Roberts, Rameez A Qudsi, Jacky Fils, George S M Dyer
BACKGROUND: Little is known about how to introduce complex technologies like arthroscopy into low-income countries. Thus, we compared low- versus high-resource intensive methods of teaching basic arthroscopic skills in a randomized controlled trial in Haiti. METHODS: Forty-eight Haitian orthopaedic surgeons and residents attending an orthopaedic conference in Haiti were block randomized to receive instruction through a composite video (Control) or a composite video plus hands-on teaching with an expert visiting surgeon (Intervention)...
March 2017: Archives of Bone and Joint Surgery
Saad Khan, Christopher M Shea, Hibah Khalid Qudsi
Health information exchanges (HIEs) offer potential data sources for public health agencies to improve chronic disease surveillance; however, public health has not yet capitalized on these data. This study identified barriers that public health departments participating in the Health Information Network of South Texas face regarding HIE and community-level surveillance of chronic diseases. This study focused on 2 health departments participating in the Health Information Network of South Texas. We administered a survey to inventory the technology infrastructure of health departments and conducted semistructured interviews of the local, state, and national officials...
May 2017: Journal of Public Health Management and Practice: JPHMP
Salima Qudsi-Sinclair, Enrique Borrás-Rubio, Juan F Abellan-Guillén, María Luz Padilla Del Rey, Guadalupe Ruiz-Merino
BACKGROUND: Knee osteoarthritis is a disease that affects a third of the population over 65 years of age, and it is increasingly becoming a motive for consultation and a source of pain and disability. The gold standard surgical treatment is a total knee arthroplasty; however, 15% to 30% of patients who have undergone surgery continue to experience pain and functional limitation. METHODS: A double-blind, randomized clinical study compared neurolysis using traditional radiofrequency (RF) to local anesthetic and corticosteroid block of the superolateral, superomedial, and inferomedial branches of the knee genicular nerves in patients who had total knee arthroplasty but still experience pain...
June 2017: Pain Practice: the Official Journal of World Institute of Pain
Brian J Yun, M G Myriam Hunink, Anand M Prabhakar, Marilyn Heng, Shan W Liu, Rameez Qudsi, Ali S Raja
OBJECTIVE: Hip fractures cause significant morbidity and mortality. Determining the optimal diagnostic strategy for the subset of patients with potential occult hip fracture remains challenging. We determined the most cost-effective strategy for the diagnosis of occult hip fractures from the choices of performing only computed tomography (CT), performing only magnetic resonance imaging (MRI), performing CT and if negative performing MRI (MRI-selective strategy) or discharging the patient without advanced imaging...
October 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Suzan Alharbi, Mona Elsafadi, Mohammed Mobarak, Ali Alrwili, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Fatma Al-Qudsi, Saleh Karim, May Al-Nabaheen, Abdullah Aldahmash, Amer Mahmood
The fine structures of mouse embryonic stem cells (mESCs) grown as colonies and differentiated in three-dimensional (3D) culture as embryoid bodies (EBs) were analyzed by transmission electron microscopy. Undifferentiated mESCs expressed markers that proved their pluripotency. Differentiated EBs expressed different differentiation marker proteins from the three germ layers. The ultrastructure of mESCs revealed the presence of microvilli on the cell surfaces, large and deep infolded nuclei, low cytoplasm-to-nuclear ratios, frequent lipid droplets, nonprominent Golgi apparatus, and smooth endoplasmic reticulum...
April 2014: Cellular Reprogramming
Ahmed H Mitwalli, Jamal S Al Wakeel, Sameer Hurraib, Abu Aisha, Abdulkaraem Al Suwaida, Awatif Alam, Durdana Hammad, Fathia Sulimani, Nawaz A Memon, Akram Askar, Ali Al Tuwaijri, Abdo Qudsi
To evaluate the outcome of low doses of cyclophosphamide (Cyclo) therapy in lupus nephritis (LN) patients, we studied 117 biopsy-proven, de novo LN WHO class IV patients double-blinded and randomized in December 1997 to receive Cyclo in different doses; Group I (n=73) received Cyclo 10 mg/kg monthly for six months then every two months for 12 months. Group II (n=44) received Cyclo 5 mg/kg monthly for six months then every two months for 36 months. The patients were followed-up till January 2007. Six months post-induction values for creatinine clearance were significantly higher in Group I (67...
September 2011: Saudi Journal of Kidney Diseases and Transplantation
Jamal Al-wakeel, Mohammad Al-Ghonaim, Abdulkareem Al-Suwaida, Akram Askar, Saira Usama, Niaz Feraz, Iqbal Hamid Shah, Nawaz Memon, Abdo Qudsi, Fathia Sulaimani
Peritoneal dialysis (PD) is a well-established modality for treatment of patients with end-stage renal disease, giving excellent patient and technique survival rates. In Saudi Arabia, data collected by the Saudi Center for Organ Transplantation showed that in 2008, patients on PD accounted for a mere 4.8% of total patients on renal replacement therapy, including hemodialysis and renal transplantation. This study was conducted to identify the characteristics of membrane permeability in the Saudi population and to assess the role of various factors affecting solute transport across the peritoneal membrane...
January 2011: Saudi Journal of Kidney Diseases and Transplantation
Carl R Walkley, Rameez Qudsi, Vijay G Sankaran, Jennifer A Perry, Monica Gostissa, Sanford I Roth, Stephen J Rodda, Erin Snay, Patricia Dunning, Frederic H Fahey, Frederick W Alt, Andrew P McMahon, Stuart H Orkin
Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis; however, the relative contribution of these mutations to the initiation of osteosarcoma is unclear. We describe here the generation and characterization of a genetically engineered mouse model in which all animals develop short latency malignant osteosarcoma. The genetically engineered mouse model is based on osteoblast-restricted deletion of p53 and pRb...
June 15, 2008: Genes & Development
Jamal S Al Wakeel, Ahmed H Mitwalli, Nauman Tarif, Durdana Hammad, Hassan Abu-Aisha, Nawaz Memon, Awatif Alam, Fathia Suliman, Akram Askar, Abdo Qudsi
To evaluate the complications of CAPD and their contributing factors in order to improve the patients' survival and reduce morbidity and mortality, we studied records of 65 CAPD patients treated at our hospital from October 1996 to January 2002. There were 32 (49%) males and the mean age of the patients was 48 +/- 16 years. All the patients were on the twin bag CAPD system. The mean duration of follow-up on CAPD was 29 +/- 20 months. There were 75 episodes of complications occurring in the patients with a rate of 0...
January 2005: Saudi Journal of Kidney Diseases and Transplantation
Nauman Tarif, Ahmed Hasan Mitwalli, Jamal Saleh Al-Wakeel, Pravin Chandra Patel, Saleh Ali Al-Smayer, Hani Kamal Najm, Abdoo Qudsi, Hassan Abu-Aisha
Aortic dissection may be associated with renal disease. The presentation, especially in the later stages of the process, includes proteinuria, hematuria and impairment of renal function. Thus the clinical picture may be confused with glomerulonephritis or hypertension. We present a case of ischemic nephropathy resulting from involvement of the right kidney by an aortic dissection. The pateint presented with the nephrotic syndrome some two and a half months after the probable time when the aortic disection had occurred...
April 2002: Saudi Journal of Kidney Diseases and Transplantation
Jamal S Al Wakeel, Ahmed H Mitwalli, Nauman Tarif, Awatif A Alam, Durdana Hammad, Hassan Abu-Aisha, Nawaz Memon, Fathia Sulimani, Akram Askar, Abdo Qudsi
Glomerulonephritis (GN) is a major cause of chronic renal failure (CRF). To evaluate the trends and outcome with modern improved treatment strategies, we retrospectively reviewed the clinical records of 120 patients with biopsy proven primary GN at our center from January 1990 to June 2001. All the biopsy specimens were subjected to light, electron and immunofluorescent microscopy. The recorded clinical parameters included the presenting symptoms, blood pressure readings, complete blood count, urinalysis, 24-hr urinary protein excretion, creatinine clearance besides rendered therapy and the outcome...
October 2004: Saudi Journal of Kidney Diseases and Transplantation
Christian Weinand, Rajiv Gupta, Albert Y Huang, Eli Weinberg, Ijad Madisch, Rameez A Qudsi, Craig M Neville, Irina Pomerantseva, Joseph P Vacanti
Availability of grafts and morbidity at the donor site limit autologous transplantation in patients requiring bone reconstruction. A tissue-engineering approach can overcome these limitations by producing bone-like tissue of custom shape and size from isolated cells. Several hydrogels facilitate osteogenesis on porous scaffolds; however, the relative suitability of various hydrogels has not been rigorously assessed. Fibrin glue, alginate, and collagen I hydrogels were mixed with swine bone marrow-derived differentiated mesenchymal stem cells (MSCs), applied to 3-dimensionally printed porous beta-tricalcium phosphate (beta-TCP) scaffolds and implanted subcutaneously in nude mice...
April 2007: Tissue Engineering
S S Al-qudsi
Relying on demographic and labor surveys which the Palestinian Central Bureau of Statistics collected in 1995, this article investigates the profile of West Bank and Gaza refugees. Refugees are better educated and have higher fertility than non-refugee Palestinians, but the difference is small. However, they have a significantly lower participation rate, a higher unemployment rate and a higher incidence of arrests and work stoppage than the corresponding rates among non-refugee Palestinians. A smaller proportion of Palestinians commute to work into the Israeli labor market and refugees earn lower wages than nonrefugees...
2000: International Migration
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