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Vanderbilt Eye Institute

Jana A Bregman, David J Herren, Christopher B Estopinal, Isaac M Chocron, Paula A Harlow, Cassandra Warden, Milam A Brantley, David C Samuels
Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank...
February 1, 2017: Investigative Ophthalmology & Visual Science
Kate Russell, Sara E Oliver, Lillianne Lewis, Wanda D Barfield, Janet Cragan, Dana Meaney-Delman, J Erin Staples, Marc Fischer, Georgina Peacock, Titilope Oduyebo, Emily E Petersen, Sherif Zaki, Cynthia A Moore, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results...
August 26, 2016: MMWR. Morbidity and Mortality Weekly Report
Paula Schanilec, Ronald Biernacki
BACKGROUND AND PURPOSE: Aniridia is linked to a mutation of the PAX6 gene, which results in panocular anomalies. A set of common secondary pathologies associated with aniridia is recognized. Much of the literature on aniridia focuses on genetic factors of the disorder and associated abnormalities, both ocular and nonocular. The field of research on the prevalence of pathology secondary to ocular abnormalities associated with aniridia is limited, with many of the studies based on low patient numbers...
2014: American Orthoptic Journal
Christopher B Estopinal, Isaac M Chocron, Megan B Parks, Emily A Wade, Rachel M Roberson, L Goodwin Burgess, Milam A Brantley, David C Samuels
PURPOSE: To determine if specific mitochondrial haplogroups associate with nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). METHODS: Deidentified medical records for Caucasian patients with diabetic retinopathy (DR; 153 NPDR and 138 PDR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An independent cohort of Caucasian patients with DR (44 NPDR and 57 PDR) from the Vanderbilt Eye Institute (VEI) was used for validation...
September 2014: Investigative Ophthalmology & Visual Science
John Kuchtey, Jessica Kunkel, L Goodwin Burgess, Megan B Parks, Milam A Brantley, Rachel W Kuchtey
PURPOSE: To test the hypothesis that primary open-angle glaucoma (POAG) patients have a systemic elevation of transforming growth factor β1 (TGFβ1). METHODS: Plasma was prepared from blood samples drawn from patients of the Vanderbilt Eye Institute during clinic visits. Concentrations of total TGFβ1 and thrombospondin-1 (TSP1) in plasma were determined by ELISA. Statistical significance of differences between POAG and control samples was evaluated by Mann-Whitney test...
August 2014: Investigative Ophthalmology & Visual Science
Scott D Schoenberger, Anita Agarwal
PURPOSE: To describe a series of patients with geographic atrophy independent of choroidal neovascularization (CNV) in pseudoxanthoma elasticum and to report progression over time. DESIGN: Retrospective observational case series. METHODS: Records of all Vanderbilt Eye Institute patients with pseudoxanthoma elasticum and at least 1 set of color fundus photographs were reviewed (41 eyes of 21 patients). Fluorescein angiography, fundus autofluorescence, and optical coherence tomography images were reviewed, when available...
October 2013: American Journal of Ophthalmology
Milam A Brantley, Melissa P Osborn, Barton J Sanders, Kasra A Rezaei, Pengcheng Lu, Chun Li, Ginger L Milne, Jiyang Cai, Paul Sternberg
PURPOSE: To determine if short-term Age-Related Eye Disease Study (AREDS) antioxidant and zinc supplementation affects biomarkers of oxidative stress, possibly serving as a predictor of their efficacy. DESIGN: Prospective interventional case series. METHODS: Nineteen subjects, 12 with intermediate or advanced age-related macular degeneration (AMD) (AREDS categories 3 or 4) and 7 non-AMD controls, were admitted to the Vanderbilt General Clinical Research Center and placed on a controlled diet for 7 days...
June 2012: American Journal of Ophthalmology
Lori Ann F Kehler, K Bradley Kehler, Lawrence M Merin, James C Tsai
PURPOSE: To correlate visual acuity measured with the Optec 800 to the gold-standard Early Treatment Diabetic Retinopathy Study (ETDRS) chart. DESIGN: Prospective, cross-sectional study. METHODS: Forty patients of the Vanderbilt Eye Institute agreed to undergo visual acuity testing. Five patients were excluded because of enucleation or functional blindness of one or both eyes. Two patients were excluded because of poor cooperation during testing...
March 2007: American Journal of Ophthalmology
Tak Yee Tania Tai, Monte D Mills, Allen D Beck, Karen M Joos, Gui-Shuang Ying, Chengcheng Liu, Jody R Piltz-Seymour
PURPOSE: To determine and compare the central corneal thickness (CCT) and corneal diameter among groups of patients with childhood glaucomas and assess the relationship between CCT and corneal diameter in these patients. DESIGN: A multicenter observational case series using prospective and retrospective data. METHODS: Patients from the Scheie Eye Institute, Children's Hospital of Philadelphia, and Emory and Vanderbilt Medical Centers with childhood glaucomas were eligible to participate...
December 2006: Journal of Glaucoma
Anita Agarwal, Purnima Patel, Tony Adkins, J Donald M Gass
OBJECTIVE: To study the prevalence, type, and features of pattern dystrophy in patients with pseudoxanthoma elasticum (PXE). METHODS: A search of the photographic records at the Vanderbilt Eye Institute using the keywords "angioid streaks and pseudoxanthoma elasticum" yielded 28 names. Of the 23 subjects meeting the patient selection criteria, 22 were confirmed to have a positive diagnosis for PXE after reviewing the medical history information. The diagnosis was confirmed by the constellation of fundus findings in all 22 subjects, by a clinical examination of the skin in 9, and by a skin biopsy specimen in 1...
July 2005: Archives of Ophthalmology
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