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https://www.readbyqxmd.com/read/29751627/anti-inflammatory-triterpenoids-from-the-caulophyllum-robustum-maximin-lps-stimulated-raw264-7-cells
#1
Bin-Hua Qin, Xin-Qiao Liu, Qiao-Yu Yuan, Jing Wang, Hai-Yan Han
Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives ( 1 ⁻ 3 ), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29749290/neither-medicine-nor-health-care-staff-members-are-violent-by-nature-obstetric-violence-from-an-interactionist-perspective
#2
Ximena Briceño Morales, Laura Victoria Enciso Chaves, Carlos Enrique Yepes Delgado
This study sought to understand the meaning that women place on the health care practices carried out during labor. We used techniques from Grounded Theory such as coding, categorization, and constant comparison. A total of 18 interviews were conducted with 16 women who had given birth at least once in Colombia. Based on our results, we argue that obstetric violence is an expression of violence during the provision of health care, which occurs in a social environment favoring the development of power relationships between patients and health care staff...
May 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29733066/de-las-primeras-iniciativas-de-medicina-laboral-en-m%C3%A3-xico-el-hospital-de-mineros-de-real-del-monte
#3
José Luis Gómez, Carlos Agustín Rodríguez-Paz
A pesar de la legislación de Otto von Bismarck (1815-1898) sobre derechos de seguridad social formulada en 1883 en Alemania donde se señala que es deber del Estado promover el bienestar de todos los miembros de la sociedad, particularmente de los más débiles y necesitados utilizando los medios con los que dispone, y las propuestas de leyes contra accidentes expedidas el 30 de abril de 1904 en el Estado de México, en el México del porfiriato no se consideró brindar atención médica formal a los trabajadores, salvo algunas empresas ferrocarrileras, no se construyeron hospitales para atender a pacientes con enfermedades laborales...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29709112/a-five-year-study-of-the-efficacy-of-purified-cd34-cell-therapy-for-angiitis-induced-no-option-critical-limb-ischemia
#4
Yuan Fang, Zheng Wei, Bin Chen, Tianyue Pan, Shiyang Gu, Peng Liu, Daqiao Guo, Xin Xu, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi, Yifan Liu, Zhihui Dong, Weiguo Fu
Angiitis-induced critical limb ischemia (AICLI) patients constitute a remarkable proportion of no-option critical limb ischemia (CLI) patients. Stem cell therapy has become an innovative and promising option for no-option CLI patients. As one of these promising stem cell therapies, purified CD34+ cell transplantation (PuCeT) has shown favorable short-term results. However, the long-term efficacy of PuCeT has yet to be reported. This study evaluates the long-term efficacy of PuCeT in AICLI patients. Twenty-seven AICLI patients were enrolled from May 2009 to December 2011...
April 30, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29699013/-investigation-and-analysis-on-shift-work-female-workers-and-the-impact-on-reproductive-health
#5
C Y Yu, W L Yu, M Xu, Z L Xing
Objective: To investigate the distribution of shift work of female workers in different industries and the relationship between shift work and reproductive health, then provide reference for the female workers' labor protection. Methods: From June to September 2016, cluster sampling questionnaire survey was performed among female workers from 11 industries including electronics, medicine and health, pharmacy. To investigate the general information, shift - work information, reproductive health and childbearing history of these female workers...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29693546/self-management-of-gestational-diabetes-among-chinese-migrants-a-qualitative-study
#6
Yat Yin Eric Wah, Margaret McGill, Jencia Wong, Glynis P Ross, Anna-Jane Harding, Ines Krass
BACKGROUND: Gestational diabetes mellitus is one of the most common complications of pregnancy. Women with Gestational diabetes are at increased risk of serious health outcomes, such as pre-eclampsia, obstructed labor, and the development of Type 2 diabetes later in life. Chinese migrants, the third largest cultural group in Australia, are more likely to develop Gestational diabetes than Australian-born women. However, to date, Gestational diabetes self-management has not been investigated in this population...
April 21, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29690730/-a-clinical-retrospective-study-on-160-cases-of-multiple-umbilical-cord-around-the-neck
#7
Y Q Zhang, W Zhao, K T Chu, Y Zhao, L P Chen, Y Yu, X J Han
Objective: To compare the neonatal and maternal outcomes between the patients with umbilical cord around the neck (≥3 loops) and with (1 or 2 loops). Methods: A retrospective analysis was conducted on the clinical data of 160 cases with multiple umbilical cord around the neck (≥3 loops) in the Department of Obstetrics, Women's Hospital School of Medicine Zhejiang University between January 2014 and April 2017.For each case, two control women who gave birth at the same day with vertex position and singletons were selected...
April 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29689578/peripartum-morbidity-after-cesarean-delivery-for-arrest-of-dilation-at-4-to-5-cm-compared-with-6-to-10-cm
#8
Joshua D Dahlke, Jeffrey D Sperling, Phinnara Has, Todd R Lovgren, Brendan D Connealy, Dwight J Rouse
OBJECTIVE:  Given that recent consensus guidelines established to decrease cesarean delivery (CD) rates use 6 cm to define the onset of the active phase of labor, our objective was to evaluate maternal and neonatal outcomes after CD for the indication of arrest of dilation at 4 to 5 cm compared with ≥ 6 cm. STUDY DESIGN:  We performed a secondary analysis using data from the Maternal Fetal-Medicine Units Network Cesarean Registry. We included nulliparous women with term, singleton, vertex gestations who underwent primary CD for arrest of dilation...
April 24, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29662902/isolation-of-extracellular-vesicles-general-methodologies-and-latest-trends
#9
REVIEW
Maria Yu Konoshenko, Evgeniy A Lekchnov, Alexander V Vlassov, Pavel P Laktionov
Background: Extracellular vesicles (EVs) play an essential role in the communication between cells and transport of diagnostically significant molecules. A wide diversity of approaches utilizing different biochemical properties of EVs and a lack of accepted protocols make data interpretation very challenging. Scope of Review: This review consolidates the data on the classical and state-of-the-art methods for isolation of EVs, including exosomes, highlighting the advantages and disadvantages of each method...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29620051/manipulation-free-cultures-of-human-ipsc-derived-cardiomyocytes-offer-a-novel-screening-method-for-cardiotoxicity
#10
Sheeja Rajasingh, Dona Greta Isai, Saheli Samanta, Zhi-Gang Zhou, Buddhadeb Dawn, William H Kinsey, Andras Czirok, Johnson Rajasingh
Induced pluripotent stem cell (iPSC)-based cardiac regenerative medicine requires the efficient generation, structural soundness and proper functioning of mature cardiomyocytes, derived from the patient's somatic cells. The most important functional property of cardiomyocytes is the ability to contract. Currently available methods routinely used to test and quantify cardiomyocyte function involve techniques that are labor-intensive, invasive, require sophisticated instruments or can adversely affect cell vitality...
April 5, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29610531/small-molecules-promote-crispr-cpf1-mediated-genome-editing-in-human-pluripotent-stem-cells
#11
Xiaojie Ma, Xi Chen, Yan Jin, Wenyan Ge, Weiyun Wang, Linghao Kong, Junfang Ji, Xing Guo, Jun Huang, Xin-Hua Feng, Junfen Fu, Saiyong Zhu
Human pluripotent stem cells (hPSCs) have potential applications in biological studies and regenerative medicine. However, precise genome editing in hPSCs remains time-consuming and labor-intensive. Here we demonstrate that the recently identified CRISPR-Cpf1 can be used to efficiently generate knockout and knockin hPSC lines. The unique properties of CRISPR-Cpf1, including shorter crRNA length and low off-target activity, are very attractive for many applications. In particular, we develop an unbiased drug-selection-based platform feasible for high-throughput screening in hPSCs and this screening system enables us to identify small molecules VE-822 and AZD-7762 that can promote CRISPR-Cpf1-mediated precise genome editing...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29607899/quality-characterization-of-japanese-medicinal-paeoniae-radix-by-metallomic-analysis
#12
Kayoko Shimada-Takaura, Yuto Nakamura, Masaya Kawase, Katsuko Komatsu, Kyoko Takahashi
Paeoniae Radix is one of the crude drugs frequently used in traditional Japanese medicine (Kampo medicine). It takes abundant labor and time to cultivate Paeonia lactiflora for medicinal use; high production cost is one of the main reasons why the domestic production of Paeoniae Radix is decreasing in Japan. To promote the production of Paeoniae Radix, we focused on Paeonia cultivars that produce commercially valuable flowers and investigated their possibility for medicinal use. We prepared 28 batches of peony roots derived from P...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29602844/impact-of-gestational-weight-gain-and-prepregnancy-body-mass-index-on-the-prevalence-of-large-for-gestational-age-infants-in-two-cohorts-of-women-with-type-1-insulin-dependent-diabetes-a-cross-sectional-population-study
#13
Ketrell L McWhorter, Katherine Bowers, Lawrence M Dolan, Ranjan Deka, Chandra L Jackson, Jane C Khoury
OBJECTIVES: Despite improvements in treatment modalities, large-for-gestational age (LGA) prevalence has remained between 30% and 40% among infants of mothers with type 1 insulin-dependent diabetes mellitus (TIDM). Our objective was to estimate LGA prevalence and examine the association between gestational weight gain (GWG) and prepregnancy body mass index (BMI) with LGA among mothers with TIDM. DESIGN: Cross-sectional study. SETTING: Regional data in Cincinnati, Ohio, from the Diabetes in Pregnancy Program Project (PPG), a prospective cohort for the period 1978-1993; national data from Consortium on Safe Labor (CSL), a multicentre cross-sectional study for the period 2002-2008...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29569926/intracellular-delivery-of-nanomaterials-via-an-inertial-microfluidic-cell-hydroporator
#14
Yanxiang Deng, Megan Kizer, Miran Rada, Jessica Sage, Xing Wang, Dong-Joo Cheon, Aram J Chung
The introduction of nanomaterials into cells is an indispensable process for studies ranging from basic biology to clinical applications. To deliver foreign nanomaterials into living cells, traditionally endocytosis, viral and lipid nanocarriers or electroporation are mainly employed; however, they critically suffer from toxicity, inconsistent delivery, and low throughput and are time-consuming and labor-intensive processes. Here, we present a novel inertial microfluidic cell hydroporator capable of delivering a wide range of nanomaterials to various cell types in a single-step without the aid of carriers or external apparatus...
March 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29554354/application-of-lean-principles-to-neurosurgical-procedures-the-case-of-lumbar-spinal-fusion-surgery-a-literature-review-and-pilot-series
#15
Jesse J Liu, Jeffrey S Raskin, Fran Hardaway, Katherine Holste, Sarah Brown, Ahmed M Raslan
BACKGROUND: Delivery of higher value healthcare is an ultimate government and public goal. Improving efficiency by standardization of surgical steps can improve patient outcomes, reduce costs, and lead to higher value healthcare. Lean principles and methodology have improved timeliness in perioperative medicine; however, process mapping of surgery itself has not been performed. OBJECTIVE: To apply Plan/Do/Study/Act (PDSA) cycles methodology to lumbar posterior instrumented fusion (PIF) using lean principles to create a standard work flow, identify waste, remove intraoperative variability, and examine feasibility among pilot cases...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29548042/maternal-fetal-medicine-workforce-survey-are-we-ready-for-regionalized-levels-of-maternal-care
#16
Katharine D Wenstrom, Mary E D'Alton, Daniel F O'Keefe
OBJECTIVE:  To conduct a survey of the members of the Society for Maternal-Fetal Medicine (SMFM) to determine the practice patterns of maternal-fetal medicine (MFM) subspecialists in the United States and to estimate the likelihood that our work force is sufficient to support the proposed MFM staffing requirements for level III and IV maternity centers. STUDY DESIGN:  All regular SMFM members in the United States were invited to answer a 26 question survey by email...
March 16, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29534380/-the-expert-consensus-of-new-standard-and-management-of-labor%C3%AF-2014%C3%AF-%C3%AF-interpretation-and-statement
#17
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29529229/present-developments-in-reaching-an-international-consensus-for-a-model-based-approach-to-particle-beam-therapy
#18
Anussara Prayongrat, Kikuo Umegaki, Arjen van der Schaaf, Albert C Koong, Steven H Lin, Thomas Whitaker, Todd McNutt, Naruhiro Matsufuji, Edward Graves, Masahiko Mizuta, Kazuhiko Ogawa, Hiroyuki Date, Kensuke Moriwaki, Yoichi M Ito, Keiji Kobashi, Yasuhiro Dekura, Shinichi Shimizu, Hiroki Shirato
Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), is necessary. Due to the cost and labor involved in randomized controlled trials, the model-based approach (MBA) is used as an alternative means of establishing scientific evidence in medicine, and it can be improved continuously...
March 1, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29478833/shifting-perspectives-planning-for-the-future-of-the-pharmacy-profession-taking-current-labor-market-trends-into-consideration
#19
Janine Marie Traulsen, Louise C Druedahl
The future of the pharmacy profession and concerns about professional identity have been popular and recurring themes in professional journals and at international pharmacy conferences for more than 30 years. The aim of this paper is to contribute to realistic and viable visions for the future of the pharmacy profession via insights through labor market and work organization theories. These insights provide an understanding of contemporary work patterns and what they mean for the future role of community pharmacists...
February 17, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29464309/nanotechnology-in-plants
#20
Ismail Ocsoy, Didar Tasdemir, Sumeyye Mazicioglu, Weihong Tan
The integration of nanotechnology in medicine has had a tremendous impact in the past few decades. The discovery of synthesis of nanomaterials (NMs) and their functions as versatile tools promoted various applications in nano-biotechnology and nanomedicine. Although the physical and chemical methods are still considered as commonly used methods, they introduce several drawbacks such as the use of toxic chemicals (solvent, reducing, and capping agents) and poor control of size, size distribution, and morphology, respectively...
February 21, 2018: Advances in Biochemical Engineering/biotechnology
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