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Igor Alexander Harsch, Anne Schiffer, Peter C Konturek
OBJECTIVE: To investigate a potential cause of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). CLINICAL PRESENTATION AND INTERVENTION: A 70-year-old female patient had nausea and collapsed. Although euvolemic, pathological laboratory findings showed hyponatremia and hypoosmolality, and cerebral magnetic resonance imaging showed hypertrophic pachymeningitis. Secondary hypertrophic pachymeningitis was excluded. Other nonneurological reasons for SIADH were also excluded...
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Jozef Kalužay, Veronika Pokorná, Svetlana Bodíková, Natália Vahančíková, Peter Ponťuch
INTRODUCTION: One of the risks of diuretic therapy for pulmonary edema is the development of hyponatremia and hypokalemia with pro-arrhythmic potential. The aim of our study was to analyze the incidence of hyponatremia and hypokalemia after the first day of treatment in a real clinical practice. METHODS: We performed a retrospective analysis of data obtained from medical records. We included all patients with pulmonary edema admitted to the coronary care unit, only patients which died within the first day of treatment were excluded...
April 2016: Vnitr̆ní Lékar̆ství
Cristiana Rollino, Rosanna Balbiano, Pietro Caramello, Dario Roccatello
Vaptans, vasopressin V2 receptor antagonists, are new drugs indicated in the treatment of Inappropriate ADH Secretion Syndrome (SIADH). We report a case of SIADH in a patient affected by AIDS. During a hospitalization for an ongoing CMV meningitis she developed a severe hyponatremia (114 mEq/L), which was initially treated with restriction of free water. When the diagnosis of SIADH was done (plasma Osmolarity 240 mOsm/kg, urinary sodium >30 mEq/24 h, normal volemia, lack of hypocorticosurrenalism and hypothyroidism), tolvaptan was given at the dose of 15 mg/day...
November 2013: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Christoph Kellinghaus, Sascha Berning, Florian Stögbauer
PURPOSE: Oxcarbazepine (OXC) is an effective anticonvulsant used for treatment of partial and secondarily generalized seizures. However, there is almost no data regarding its effectiveness and tolerability when used for treatment of status epilepticus (SE). METHODS: We retrospectively identified all patients who received OXC for treatment of SE in our hospital between July 2008 and December 2010 in our hospital and analyzed all available data. RESULTS: We identified 13 patients (median age 79 years) who were treated with OXC for refractory SE after failure of first- and second-line therapy in our institution...
February 2014: Seizure: the Journal of the British Epilepsy Association
Gianluca Floris, Francesca Di Stefano, Rosanna Melis, Maria Valeria Cherchi, Francesco Marrosu
No abstract text is available yet for this article.
November 5, 2013: Neurology
(no author information available yet)
The analysis is given of the technique, tolerance, clinical efficacy, safety, results of transurethral resection in physiological salt solution (TRPSS) performed in 788 patients from August, 2005 to November, 2010 for different diseases of the lower urinary tract and prostatic gland. TRPSS made it possible to operate patients whom transurethral resection was contraindicated, for example, those with a pacemaker, to reduce a complications rate, for instance, the obturator nerve reflex. Irrigation with isotonic salt solution prevents dilution hyponatriemia and TUR-syndrome thus increasing safe time of the resection for maximal removal of the tissue...
March 2012: Urologii︠a︡
C Martin, T Steinke, M Bucher, C Raspé
An Addisonian crisis marks an acute adrenocortical failure which can be caused by decompensation of a chronic insufficiency due to stress, an infarct or bleeding of the adrenal cortex and also abrupt termination of a long-term glucocorticoid medication. This article reports the case of a 25-year-old patient with Crohn's disease who suffered an Addisonian crisis with hypotension, hyponatriemia and hypoglycemia during an emergency laparotomy after he had terminated prednisolone medication on his own authority...
June 2012: Der Anaesthesist
M Rudnay, P Hrabčáková, I Lazúrová
Hyponatremia is the most common electrolyte imbalance in outpatients and hospital inpatients and the syndrom of inappropriate secretion of antidiuretic hormone (SIADH) is one of the common causes of euvolemic hyponatremia. Recent studies showed significantly higher mortality and morbidity of hyponatriemic patients compared to normonatriemic controls. Moreover the morbidity and mortality of hyponatremic patients significantly increases in nontreated in comparison to those with the therapy. Clinical consequences of hyponatremia in SIADH could be devided according to stage of the disorder...
January 2012: Vnitr̆ní Lékar̆ství
H J Heppner, B Sehlhoff, D Niklaus, L Pientka, U Thiem
BACKGROUND: Aspiration pneumonia is associated with a high morbidity and mortality in elderly patients. In order to provide risk-adapted medical care, it is necessary to establish valid prognostic tools for these patients. OBJECTIVE: The value of two well-established scores to assess prognosis in community-acquired pneumonia (CAP), i.e., CURB-65 and the Pneumonia Severity Index (PSI), was evaluated in elderly patients hospitalized for aspiration pneumonia. MATERIAL AND METHODS: A total of 209 patients hospitalized with aspiration pneumonia between 2001 and 2005 in a single center were evaluated using PSI and CURB-65...
August 2011: Zeitschrift Für Gerontologie und Geriatrie
Maurizio Cavallini, Maria Gabriella Saracco, Marco Aguggia
Postoperative delirium is one of the most spectacular, frightening and misdiagnosed postoperative complications of surgery. We describe the case of a caucasian 77-year-old male patient, who developed a severe postoperative delirium after combined transurethral resection of the prostate and cystolithotripsy. This systemic and unpredictable complication of endoscopic surgery is caused by excessive absorption of electrolyte-free irrigation fluids, leading to brain edema and metabolic encephalopathy. The clinical spectrum ranges from asymptomatic hyponatraemia, to electrocardiographic (ECG) changes, nausea, vomiting, convulsions, coma, pulmonary edema, cardiovascular compromise and death...
June 2011: Acta Neurologica Belgica
Béatrice Rouzaire-Dubois, Gilles Ouanounou, Jean Marc Dubois
The cell volume, which controls numerous cellular functions, is theoretically linearly related with the inverse osmolarity. However, deviations from this law have often been observed. In order to clarify the origin of these deviations we electronically measured the mean cell volume of rat glioma cells under three different experimental conditions, namely: at different osmolarities and constant NaCl concentration; at different NaCl concentrations and constant osmolarity and at different osmolarities caused by changes in NaCl concentration...
June 2011: General Physiology and Biophysics
Alexander P Reske, Dierk Schreiter, Udo X Kaisers, Ulrich Stölzel
UNLABELLED: A forty-five year old male tourist suffers a febrile illness, delirium and severe abdominal pain on the fifth day of his holiday trip to the Canary Islands (Spain). After hospitalization he presents a surgical abdomen which requires emergency laparotomy however without detectable pathology. Progressing critical illness and septic shock leads to multiple organ failure, but focus identification is not possible. Well after return to Germany diagnostic uncertainty persists due to recurrent fever and possible travel-associated infections...
April 2010: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
U Stölzel, C Brosche, C Koszka, T Stauch, A Teubner, M O Doss
Acute porphyrias are caused by enzyme defects along the heme synthesis pathway. Patients usually present with abdominal pain, impaired intestinal motility, neurological and psychiatric symptoms, hypertension, tachycardia, hyponatriemia and reddish urine. This article gives an overview over drugs that are recommended in patients with acute hepatic porphyrias and represents a compilation of four so far existing lists.
2009: Cellular and Molecular Biology
R Osinga, F Hess-Sigrist, D Wegener, M Wiens, Ch Hess
We report the case of a 84 year old patient who developed a syndrome of inappropriate antidiuretic hormone secretion (SIADH) with severe hyponatremia in the context of a localized herpes zoster L1/2. This is a rare but known complication of localized varizella zoster infection. Under water restriction and salt administration the hyponatremia was corrected slowly. One month after hospital discharge the patient showed a normal sodium value without diet.
April 29, 2009: Praxis
A Höblinger, K Tiemann, G Nickenig, T Sauerbruch, F Lammert
This report presents the first case of complete resolution of ascites after transcoronary ablation of septal hypertrophy (TASH) in a cirrhotic patient with concomitant hypertrophic cardiomyopathy (HOCM). A 52-years-old woman with decompensated alcoholic liver cirrhosis was referred to our department for placement of a transjugular intrahepatic portosystemic stent shunt (TIPS) to treat her refractory ascites. The initial treatment with furosemide and spironolactone had to be discontinued because of severe hyponatriemia and an increase of creatinine levels...
October 2008: Zeitschrift Für Gastroenterologie
Julia Roggendorf, Lothar Burghaus, Wei-Chi Liu, Simon Weisenbach, Carsten Eggers, Gereon R Fink, Ruediger Hilker
We report on a woman with delayed-onset of belly dancer's syndrome 5 months after central pontine and extrapontine myelinolysis (CPM/EPM) and severe hyponatriemia. This case demonstrates that basal ganglia lesions in EPM can be the underlying pathoanatomic substrate for the rarely observed belly dancer's syndrome. The sequential appearance of extrapyramidal symptoms might reflect an ongoing but ineffective or deficient remyelination process. The presence of CPM/EPM should be considered in patients with involuntary dyskinesias of the abdominal wall...
April 30, 2007: Movement Disorders: Official Journal of the Movement Disorder Society
G H Heine, U Sester, H Köhler
Volume retention in heart failure, nephrotic syndrome, and liver cirrhosis reflects pathological changes in homeostatic mechanisms that regulate the extracellular volume (sympathetic activity, renin-angiotensin-aldosterone system [RAAS], natriuretic peptides) and plasma osmolality (antidiuretic hormone [ADH]). In heart failure and liver cirrhosis, these changes are induced by a reduction of the effective circulating volume, which is the part of the extracellular fluid that is within the arterial system and effectively perfusing the tissues...
November 2006: Der Internist
Josef Finsterer
Diagnosing mitochondrial disorder remains a challenge. In a 75-year-old women, with short stature, muscle cramps, ptosis, fasciculations and progressive, proximal limb weakness and wasting, hyponatriemia, abnormal lactate-stress-test, and slightly abnormal electromyography, muscle biopsy suggested granulomatous myositis. Corticosteroids and azathioprin were ineffective. After a second work-up amyotrophic-lateral-sclerosis was diagnosed. Riluzole was started, without effect. She developed respiratory insufficiency, requiring mechanical ventilation...
August 2006: International Journal of Neuroscience
A Liotta, M C Maggio, R Iachininoto, P F Bellipanni, G Calì, V Arena, F Arena
PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition...
March 2004: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
A Liotta, M C Maggio, R Iachininoto, P F Bellipanni, G Calì, V Arena, E Arena
PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition...
September 2003: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
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