keyword
https://read.qxmd.com/read/38066183/how-to-slay-your-zombies
#21
A R Siders, Nicola Ulibarri, Amanda E Cravens, Rebecca L Nelson
No abstract text is available yet for this article.
December 8, 2023: Nature
https://read.qxmd.com/read/37994760/unraveling-the-role-of-prickly-pear-extract-as-a-potent-nutraceutical-agent-against-metabolic-syndromes
#22
REVIEW
K Dhuli, G Bonetti, C Micheletti, A Macchia, A Iaconelli, B Aquilanti, G Matera, M R Ceccarini, T Beccari, M Bertelli
BACKGROUND: Prickly pear (Opuntia) extracts have garnered con-siderable attention in recent years due to their promising medicinal and nutritional properties. This comprehensive review explores the multifaceted potential of prickly pear extracts in mitigating various chronic diseases, including cardiovascular diseases (CVDs), diabetes, obesity, cancer, neuronal diseases, and renal diseases. METHODS: This review provides a comprehensive overview of the diverse therapeutic applications of Opuntia extracts in managing chronic diseases...
2023: La Clinica Terapeutica
https://read.qxmd.com/read/37990887/chemical-profile-of-the-anatolian-sideritis-species-with-bioactivity-studies
#23
REVIEW
Sema Çarıkçı, Turgut Kılıç, Ahmet C Gören, Tuncay Dirmenci, Gülbahar Özge Alim Toraman, Gülaçtı Topçu
CONTEXT: The genus Sideritis L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia. OBJECTIVE: In this review article, Sideritis species growing in Turkey have been evaluated for phytochemical constituents and biological activities. METHODS: The data for the isolates, components and extracts of the Anatolian Sideritis species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/37955411/endemic-mountain-tea-sideritis-dichotoma-huter-antioxidant-and-antibacterial-activities-mineral-content-by-icp-ms-and-phytochemical-content-by-lchr-ms
#24
JOURNAL ARTICLE
S Beyza Ozturk Sarikaya, Cuma Zehiroglu
Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25% of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPH• scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S...
November 13, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37952497/pomegranate-peel-chokeberry-leaves-and-ironwort-extract-as-novel-natural-inhibitors-of-amylin-aggregation-and-cellular-toxicity-in-pancreatic-%C3%AE-cells
#25
JOURNAL ARTICLE
Achanta Rishisree, Brayer Mallory, Karnaukhova Elena, Jankovic Teodora, Zdunić Gordana, Šavikin Katarina, Jeremic Aleksandar
Impeding or reducing human amylin aggregation and/or its toxicity can be key to preventing pancreatic islet amyloidosis and β-cell loss in patients with Type 2 Diabetes Mellitus (T2DM). Here, Punica granatum (pomegranate) peel, Sideritis raeseri (ironwort) and Aronia melanocarpa (chokeberry) leaf extracts, were tested for their novel anti-aggregative and antitoxic properties in human amylin (hIAPP) treated rat pancreatic insulinoma (INS) cells. The protein aggregation (Th-T) assay revealed an inhibitory trend of all three plant extracts against amylin aggregates...
October 31, 2023: Biophysical Chemistry
https://read.qxmd.com/read/37878431/adaptive-transfer-of-graph-neural-networks-for-few-shot-molecular-property-prediction
#26
JOURNAL ARTICLE
Baoquan Zhang, Chuyao Luo, Hao Jiang, Shanshan Feng, Xutao Li, Bowen Zhang, Yunming Ye
Few-Shot Molecular Property Prediction (FSMPP) is an improtant task on drug discovery, which aims to learn transferable knowledge from base property prediction tasks with sufficient data for predicting novel properties with few labeled molecules. Its key challenge is how to alleviate the data scarcity issue of novel properties. Pretrained Graph Neural Network (GNN) based FSMPP methods effectively address the challenge by pre-training a GNN from large-scale self-supervised tasks and then finetuning it on base property prediction tasks to perform novel property prediction...
October 25, 2023: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://read.qxmd.com/read/37803700/vineyard-mediated-factors-are-still-operative-in-spontaneous-and-commercial-fermentations-shaping-the-vinification-microbial-community-and-affecting-the-antioxidant-and-anticancer-properties-of-wines
#27
JOURNAL ARTICLE
Elena Papadopoulou, Fotiοs Bekris, Sotirios Vasileiadis, Afroditi Krokida, Theodora Rouvali, Aristidis S Veskoukis, Kalliopi Liadaki, Demetrios Kouretas, Dimitrios G Karpouzas
The grapevine and vinification microbiota have a strong influence on the characteristics of the produced wine. Currently we have a good understanding of the role of vineyard-associated factors, like cultivar, vintage and terroir in shaping the grapevine microbiota. Notwithstanding, their endurance along the vinification process remains unknown. Thus, the main objective of our study was to determine how these factors influence (a) microbial succession during fermentation (i.e., bacterial and fungal) and (b) the antioxidant, antimutagenic and anticancer potential of the produced wines...
November 2023: Food Research International
https://read.qxmd.com/read/37799208/genetic-mapping-of-the-p47-l-3-2-mutation-in-drosophila-melanogaster
#28
JOURNAL ARTICLE
Chloe N Cordes, Melissa M Gouge, Hannah Morgan, Carah Porter, Jamie Siders, Erica Bacab, Briana Barin, Ixel A Becerra, Jose Castillo, Jared Church, Shaunacee Condo-Hicks, Kattleya J Conroy, Isbel Curbelo-Navarro, Benjamin J DePrest, Adrienne Eady, TyMahni Edmead, Verena Farouk, Angelica Flores-Torres, Michael Girmai, Cynthia I Gutierrez Navarro, Stan Guzman, Alexis B Harris, Karin Healy, Alina Jaafar, Abraham Khadr, Melissa N Kiboi, Stephanie N Korte, Celia Lopez, Hyder Mahdi, Jennifer Mendoza Avalos, Kathy Miranda, Dipti Patel, Celia Lopez, Hyder Mahdi, Jennifer Mendoza Avalos, Kathy Miranda, Dipti Patel, Rishi Patel, Sydney Pechulis, Victoria Plachta, Kamryn Rhodes, Andrea M Sandoval, Caila Thomas, Joselyn A Valadez-Mendoza, Hannah Vora, Jonathan Yousif, Kayla L Bieser, Jacob D Kagey
An EMS-based forward genetic screen was conducted in an apoptotic null background to identify genetic aberrations that contribute to regulation of cell growth in Drosophila melanogaster . The current work maps the genomic location of one of the identified mutants, L.3.2 . Genetic crosses conducted through the Fly-CURE consortium determined that the gene locus for the L.3.2 mutation is p47 on chromosome 2R.
2023: microPublication. Biology
https://read.qxmd.com/read/37761205/kombucha-fermentation-of-olympus-mountain-tea-sideritis-scardica-sweetened-with-thyme-honey-physicochemical-analysis-and-evaluation-of-functional-properties
#29
JOURNAL ARTICLE
Ioannis Geraris Kartelias, Haralabos Christos Karantonis, Efstathios Giaouris, Ioannis Panagiotakopoulos, Constantina Nasopoulou
This study implemented kombucha fermentation of Olympus Mountain tea ( Sideritis scardica ) sweetened with honey (OMTWH) in order to investigate the potential for producing a novel beverage with functional properties. The increase in the total count of bacteria and yeast suggests that the OMTWH acts as a viable substrate for supporting the proliferation of the microorganisms of the Kombucha symbiotic culture. The fermentation resulted in a reduction in pH and increased total titratable acidity. After fermentation, a statistically significant increase in the vitamins C, B1, B2, B6, B7, and B12 content was observed ( p < 0...
September 20, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/37731965/periodic-ethanol-supply-as-a-path-toward-unlimited-lifespan-of-caenorhabditis-elegans-dauer-larvae
#30
JOURNAL ARTICLE
Xingyu Zhang, Sider Penkov, Teymuras V Kurzchalia, Vasily Zaburdaev
The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity. Recent findings suggest that the dauer larva of Caenorhabditis elegans may utilize external ethanol as an energy source to extend their lifespan. It was shown that while ethanol may serve as an effectively infinite source of energy, some toxic compounds accumulating as byproducts of its metabolism may lead to the damage of mitochondria and thus limit the lifespan of larvae...
2023: Front Aging
https://read.qxmd.com/read/37721836/new-limits-on-exotic-spin-dependent-interactions-at-astronomical-distances
#31
JOURNAL ARTICLE
L Y Wu, K Y Zhang, M Peng, J Gong, H Yan
Exotic spin-dependent interactions involving new light particles address key questions in modern physics. Interactions between polarized neutrons (n) and unpolarized nucleons (N) occur in three forms: g_{S}^{N}g_{P}^{n}σ·r, g_{V}^{N}g_{A}^{n}σ·v, and g_{A}^{N}g_{A}^{n}σ·v×r, where σ is the spin and g's are the corresponding coupling constants for scalar, pseudoscalar, vector, and axial-vector vertexes. If such interactions exist, the Sun and Moon could induce sidereal variations of effective fields in laboratories...
September 1, 2023: Physical Review Letters
https://read.qxmd.com/read/37655384/subchronic-toxicity-of-sideritis-scardica-lamiaceae-on-male-wistar-rats
#32
JOURNAL ARTICLE
Nikolay B Yanchev, Delian P Delev, Natalia B Vilmosh, Pepa K Atanassova, Petar I Hrischev
Sideritisscardica, Lamiaceae, is a plant with anti-inflammatory, antirheumatic, digestive, and antimicrobial properties that is widely used in folk medicine throughout the Balkan Peninsula. The name derives from the Greek word 'sideros', meaning iron, and it is believed that the plant was also used by soldiers to heal wounds caused by cutting weapons.
August 31, 2023: Folia Medica
https://read.qxmd.com/read/37559244/the-basal-ganglia-and-mesencephalic-locomotor-region-connectivity-matrix
#33
JOURNAL ARTICLE
Nicolás A Morgenstern, Maria S Esposito
Although classically considered a relay station for basal ganglia (BG) output, the anatomy, connectivity, and function of the mesencephalic locomotor region (MLR) were redefined during the last two decades. In striking opposition to what was initially thought, MLR and BG are actually recip- rocally and intimately interconnected. New viral-based, optogenetic, and mapping technologies re- vealed that cholinergic, glutamatergic, and GABAergic neurons coexist in this structure, which, in ad- dition to extending descending projections, send long-range ascending fibers to the BG...
August 9, 2023: Current Neuropharmacology
https://read.qxmd.com/read/37509192/chemical-composition-of-the-essential-oils-of-three-popular-sideritis-species-cultivated-in-greece-using-gc-ms-analysis
#34
JOURNAL ARTICLE
Eleftheria H Kaparakou, Dimitra Daferera, Charalabos D Kanakis, Efstathia Skotti, Maroula G Kokotou, Petros A Tarantilis
(1) Background: The essential oils (EOs) of Sideritis L. have attracted great interest due to their pharmacological activities and potential applications in the cosmetic and perfume industries. The aim of this work was to study the EO chemical composition of three of the most popular, in Greece, mountain tea species: namely, these include Sideritis scardica , Sideritis raeseri , and Sideritis syriaca . (2) Methods: The EOs were obtained from the aerial parts of three Sideritis species that were cultivated in various regions of Greece by hydrodistillation, and the chemical composition was studied by gas chromatography-mass spectrometry (GC-MS) analysis...
July 20, 2023: Biomolecules
https://read.qxmd.com/read/37508395/somatic-growth-and-maturity-for-four-species-of-river-cooter-including-pseudemys-concinna-suwanniensis-p-nelsoni-p-peninsularis-and-p-texana
#35
JOURNAL ARTICLE
Zachary A Siders, Theresa A Stratmann, Calandra N Turner Tomaszewicz, Andrew D Walde, Eric C Munscher
Pseudemys is a genus of commonly occurring freshwater turtles with limited growth information across their long lifespans. We used 11,361 mark-recapture events to estimate the somatic growth rates of P. nelsoni , P. peninsularis , P. concinna suwanniensis , and P. texana from freshwater springs and developed a Bayesian growth model to estimate the species-specific, site-specific, and individual effects on growth. We corroborated evidence for fast juvenile growth and slower adult growth in Pseudemys but found uncommonly fast growth rates, with turtles doubling or tripling in size in the first year...
July 6, 2023: Biology
https://read.qxmd.com/read/37447102/plant-growth-regulators-and-activated-charcoal-selectively-affect-phenylethanoid-and-flavone-glycoside-accumulation-in-sideritis-scardica-griseb-tissue-culture
#36
JOURNAL ARTICLE
Kalina Danova, Jasmina Petreska Stanoeva, Ina Aneva, Kalina Alipieva, Marina Stefova
Sideritis scardica Griseb. is a Balkan endemic species traditionally used for the treatment of pulmonary emphysema and angina pectoris. Recent research has also shown its phytotherapeutic potential as an anticancer and neuroprotective agent. These findings, as well as the endangered status of the species in its wild habitats, have motivated the present research on application of plant cell tissue and organ culture for the purposes of both valuable germplasm conservation and secondary metabolites production...
July 4, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37424668/effects-of-repeated-in-vitro-exposure-to-saudi-honey-on-bacterial-resistance-to-antibiotics-and-biofilm-formation
#37
JOURNAL ARTICLE
Abdu Aldarhami, Abdulrahman S Bazaid, Husam Qanash, Iqbal Ahmad, Fahad H Alshammari, Abdulrahman M Alshammari, Abdulrahman H Alshammari, Fahad M Aljanfawe, Bushra Aldamiri, Esraa Aldawood, Mashail A Alghamdi, Naif K Binsaleh, Nizar H Saeedi, Mejdi Snoussi
INTRODUCTION: Although Sumra and Sidr Saudi honey is widely used in traditional medicine due to its potent activity, it is unknown whether its prolonged usage has impact upon bacterial virulence or leading to reduced antibiotic sensitivity. Thus, the study aims to investigate the effect of prolonged (repeated) in-vitro exposure to Saudi honey on the antibiotic susceptibility profiles and biofilm formation of pathogenic bacteria. METHODS: Several bacteria, including Staphylococcus aureus, Escherichia coli , and Acinetobacter baumannii , were in-vitro exposed ten times [passaged (P10)]to Sumra and Sider honey individually to introduce adapted bacteria (P10)...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37375165/screening-of-volatile-compounds-traditional-and-modern-phytotherapy-approaches-of-selected-non-aromatic-medicinal-plants-lamiaceae-lamioideae-from-rtanj-mountain-eastern-serbia
#38
JOURNAL ARTICLE
Milica Aćimović, Jovana Stanković Jeremić, Ana Miljković, Milica Rat, Biljana Lončar
Ironwort ( Sideritis montana L.), mountain germander ( Teucrium montanum L.), wall germander ( Teucrium chamaedrys L.), and horehound ( Marrubium peregrinum L.) are species widely distributed across Europe and are also found in North Africa and West Asia. Because of their wide distribution they express significant chemical diversity. For generations, these plants have been used as medical herbs for treating different aliments. The aim of this paper is to analyze volatile compounds of four selected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientifically proven biological activities and potential uses in modern phytotherapy in relation to traditional medicine...
June 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37241947/comparative-study-on-assisted-solvent-extraction-techniques-for-the-extraction-of-biologically-active-compounds-from-sideritis-raeseri-and-sideritis-scardica
#39
JOURNAL ARTICLE
Marika Mróz, Edyta Malinowska-Pańczyk, Agnieszka Bartoszek, Barbara Kusznierewicz
The plants in the Sideritis genus are postulated to exhibit several important medicinal properties due to their unique chemical composition. To isolate the targeted phytochemical compounds, the selection of a suitable extraction method is of primary importance. In this work, a comparative study on the phytochemical profiles of various Sideritis raeseri and Sideritis scardica extracts has been carried out. An untargeted metabolomics approach based on ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry was applied to investigate the metabolic differences between extracts obtained by conventional extraction and extractions assisted by microwaves, ultrasounds and high pressure...
May 20, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37171216/an-interpretable-multitask-framework-bilat-enables-accurate-prediction-of-cyclin-dependent-protein-kinase-inhibitors
#40
JOURNAL ARTICLE
Xu Qian, Xiaowen Dai, Lin Luo, Mingde Lin, Yuan Xu, Yang Zhao, Dingfang Huang, Haodi Qiu, Li Liang, Haichun Liu, Yingbo Liu, Lingxi Gu, Tao Lu, Yadong Chen, Yanmin Zhang
The cyclin-dependent protein kinases (CDKs) are protein-serine/threonine kinases with crucial effects on the regulation of cell cycle and transcription. CDKs can be a hallmark of cancer since their excessive expression could lead to impaired cell proliferation. However, the selectivity profile of most developed CDK inhibitors is not enough, which have hindered the therapeutic use of CDK inhibitors. In this study, we propose a multitask deep learning framework called BiLAT based on SMILES representation for the prediction of the inhibitory activity of molecules on eight CDK subtypes (CDK1, 2, 4-9)...
May 12, 2023: Journal of Chemical Information and Modeling
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