keyword
MENU ▼
Read by QxMD icon Read
search

sideritis

keyword
https://www.readbyqxmd.com/read/28408735/predicting-neurological-adverse-drug-reactions-based-on-biological-chemical-and-phenotypic-properties-of-drugs-using-machine-learning-models
#1
Salma Jamal, Sukriti Goyal, Asheesh Shanker, Abhinav Grover
Adverse drug reactions (ADRs) have become one of the primary reasons for the failure of drugs and a leading cause of deaths. Owing to the severe effects of ADRs, there is an urgent need for the generation of effective models which can accurately predict ADRs during early stages of drug development based on integration of various features of drugs. In the current study, we have focused on neurological ADRs and have used various properties of drugs that include biological properties (targets, transporters and enzymes), chemical properties (substructure fingerprints), phenotypic properties (side effects (SE) and therapeutic indications) and a combinations of the two and three levels of features...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388386/life-after-breast-prostate-and-colon-cancer-primary-care-s-role
#2
REVIEW
Emily E Jonczak, Elizabeth R Stone, Cristina I Pravia, Darby Sider
When patients survive cancer, they eventually come back to their primary care physicians. This group has special needs, including surveillance for recurrent and new cancer, health promotion, and interventions to mitigate the lingering effects of the cancer and the adverse effects of its treatment.
April 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28387744/characteristics-of-the-bds-carrier-phase-multipath-and-its-mitigation-methods-in-relative-positioning
#3
Wujiao Dai, Qiang Shi, Changsheng Cai
The carrier phase multipath effect is one of the most significant error sources in the precise positioning of BeiDou Navigation Satellite System (BDS). We analyzed the characteristics of BDS multipath, and found the multipath errors of geostationary earth orbit (GEO) satellite signals are systematic, whereas those of inclined geosynchronous orbit (IGSO) or medium earth orbit (MEO) satellites are both systematic and random. The modified multipath mitigation methods, including sidereal filtering algorithm and multipath hemispherical map (MHM) model, were used to improve BDS dynamic deformation monitoring...
April 7, 2017: Sensors
https://www.readbyqxmd.com/read/28369040/phosphorylated-glycosphingolipids-essential-for-cholesterol-mobilization-in-caenorhabditis-elegans
#4
Sebastian Boland, Ulrike Schmidt, Vyacheslav Zagoriy, Julio L Sampaio, Raphael F Fritsche, Regina Czerwonka, Tilo Lübken, Jakob Reimann, Sider Penkov, Hans-Joachim Knölker, Teymuras V Kurzchalia
The nematode Caenorhabditis elegans requires exogenous cholesterol to survive and its depletion leads to early developmental arrest. Thus, tight regulation of cholesterol storage and distribution within the organism is indispensable. Here, we present a novel class of C. elegans phosphorylated glycosphingolipids, phosphoethanolamine glucosylceramides (PEGCs), capable of rescuing larval arrest induced by sterol starvation. We describe the total synthesis of a major PEGC species and demonstrate that the PEGC synthetic counterpart suppresses the dauer-constitutive phenotype of Niemann-Pick C1 (NPC1) and DAF-7/TGF-β mutant worms caused by impaired intracellular sterol trafficking...
April 3, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#5
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28298238/biofed-federated-query-processing-over-life-sciences-linked-open-data
#6
Ali Hasnain, Qaiser Mehmood, Syeda Sana E Zainab, Muhammad Saleem, Claude Warren, Durre Zehra, Stefan Decker, Dietrich Rebholz-Schuhmann
BACKGROUND: Biomedical data, e.g. from knowledge bases and ontologies, is increasingly made available following open linked data principles, at best as RDF triple data. This is a necessary step towards unified access to biological data sets, but this still requires solutions to query multiple endpoints for their heterogeneous data to eventually retrieve all the meaningful information. Suggested solutions are based on query federation approaches, which require the submission of SPARQL queries to endpoints...
March 15, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28172976/p591-therapeutic-drug-monitoring-in-paediatric-inflammatory-bowel-disease-on-maintenance-infliximab-and-adalimumab-treatment-improves-clinical-remission-with-a-proactive-approach
#7
S Chadokufa, S Sider, B Huggett, T Sawney, N Shah, M Baycheva, A Zambrano Perez, N Acton, F Kiparissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172815/p579-complete-disease-resolution-after-allogenic-hematopoietic-stem-cell-transplantation-in-children-with-very-early-onset-inflammatory-disease-and-no-identified-monogenic-mutation
#8
A Zambrano Perez, M Elawad, F Kiparissi, N Shah, S Chadokufa, S Sider, B Huggett
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172769/p707-paediatric-ibd-patients-do-not-meet-the-daily-recommendations-of-vitamin-d-and-calcium-intake-survey-based-analysis-in-a-tertiary-centre
#9
R Shergill-Bonner, A Zambrano Perez, N Acton, S Chadokufa, B Huggett, F Kiparissi, M Baycheva, N Shah, S Sider
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172761/p479-shifting-the-shunters-in-a-paediatric-inflammatory-bowel-disease-population-thiopurine-dose-splitting-versus-allopurinol-and-thiopurine-co-therapy
#10
S Chadokufa, M Baycheva, T Sawney, N Acton, S Sider, N Shah, B Huggett, R Dziubak, F Kiparrissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28094957/spatially-resolved-imaging-on-photocarrier-generations-and-band-alignments-at-perovskite-pbi2-heterointerfaces-of-perovskite-solar-cells-by-light-modulated-scanning-tunneling-microscopy
#11
Min-Chuan Shih, Shao-Sian Li, Cheng-Hua Hsieh, Ying-Chiao Wang, Hung-Duen Yang, Ya-Ping Chiu, Chia-Seng Chang, Chun-Wei Chen
The presence of the PbI2 passivation layers at perovskite crystal grains has been found to considerably affect the charge carrier transport behaviors and device performance of perovskite solar cells. This work demonstrates the application of a novel light-modulated scanning tunneling microscopy (LM-STM) technique to reveal the interfacial electronic structures at the heterointerfaces between CH3NH3PbI3 perovskite crystals and PbI2 passivation layers of individual perovskite grains under light illumination. Most importantly, this technique enabled the first observation of spatially resolved mapping images of photoinduced interfacial band bending of valence bands and conduction bands and the photogenerated electron and hole carriers at the heterointerfaces of perovskite crystal grains...
January 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28087585/standard-based-comprehensive-detection-of-adverse-drug-reaction-signals-from-nursing-statements-and-laboratory-results-in-electronic-health-records
#12
Suehyun Lee, Jiyeob Choi, Hun-Sung Kim, Grace Juyun Kim, Kye Hwa Lee, Chan Hee Park, Jongsoo Han, Dukyong Yoon, Man Young Park, Rae Woong Park, Hye-Ryun Kang, Ju Han Kim
OBJECTIVE: We propose 2 Medical Dictionary for Regulatory Activities-enabled pharmacovigilance algorithms, MetaLAB and MetaNurse, powered by a per-year meta-analysis technique and improved subject sampling strategy. MATRIALS AND METHODS: This study developed 2 novel algorithms, MetaLAB for laboratory abnormalities and MetaNurse for standard nursing statements, as significantly improved versions of our previous electronic health record (EHR)-based pharmacovigilance method, called CLEAR...
January 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27993785/predict-drug-permeability-to-blood-brain-barrier-from-clinical-phenotypes-drug-side-effects-and-drug-indications
#13
Zhen Gao, Yang Chen, Xiaoshu Cai, Rong Xu
Motivation: Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Central Nervous System (CNS). Determination of compound's permeability to BBB is prerequisite in CNS drug discovery. Existing computational methods usually predict drug BBB permeability from chemical structure and they generally apply to small compounds passing BBB through passive diffusion. As abundant information on drug side effects and indications has been recorded over time through extensive clinical usage, we aim to explore BBB permeability prediction from a new angle and introduce a novel approach to predict BBB permeability from drug clinical phenotypes (drug side effects and drug indications)...
March 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27976016/effect-of-activated-charcoal-on-the-developmental-patterns-polyphenolics-productivity-and-photosynthetic-activity-of-sideritis-scardica-in-vitro
#14
P Koleva, N Petrova, S Krumova, V Velikova, I Aneva, L Evstatieva, E Wolfram, K Danova
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27917720/ultrasound-promoted-synthesis-and-anticoagulant-activity-of-2-amino-4h-chromen-4-ylphosphonates
#15
Sarva Santhisudha, Tellamekala Sreekanth, Sudileti Murali, Bathal Vijaya Kumar, Meruva Anila Devi, Cirandur Suresh Reddy
BACKGROUND: One of the alarming difficulties in the field of hematology is the Coagulant disorders. Despite the availability of clinically proven existing anticoagulants, their limitations have prompted a continuous search for novel anticoagulants. OBJECTIVE: The primary objective of the study is to synthesize a series of 2-amino-4H-chromen-4-ylphosphonate derivatives and to test their anticoagulant activity depending on PT measurements con-sidering commercial heparin as positive control...
December 4, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27907064/nad-is-a-food-component-that-promotes-exit-from-dauer-diapause-in-caenorhabditis-elegans
#16
Mykola Mylenko, Sebastian Boland, Sider Penkov, Julio L Sampaio, Benoit Lombardot, Daniela Vorkel, Jean-Marc Verbavatz, Teymuras V Kurzchalia
The free-living soil nematode Caenorhabditis elegans adapts its development to the availability of food. When food is scarce and population density is high, worms enter a developmentally arrested non-feeding diapause stage specialized for long-term survival called the dauer larva. When food becomes available, they exit from the dauer stage, resume growth and reproduction. It has been postulated that compound(s) present in food, referred to as the "food signal", promote exit from the dauer stage. In this study, we have identified NAD+ as a component of bacterial extract that promotes dauer exit...
2016: PloS One
https://www.readbyqxmd.com/read/27894370/-aut-sider-the-invisible-talent-of-simona-concaro%C3%A2
#17
L Fusar-Poli, M Rocchetti, M Garda, P Politi
No abstract text is available yet for this article.
April 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27766937/leveraging-graph-topology-and-semantic-context-for-pharmacovigilance-through-twitter-streams
#18
Ryan Eshleman, Rahul Singh
BACKGROUND: Adverse drug events (ADEs) constitute one of the leading causes of post-therapeutic death and their identification constitutes an important challenge of modern precision medicine. Unfortunately, the onset and effects of ADEs are often underreported complicating timely intervention. At over 500 million posts per day, Twitter is a commonly used social media platform. The ubiquity of day-to-day personal information exchange on Twitter makes it a promising target for data mining for ADE identification and intervention...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27746923/crystal-structure-of-3-4a-7-7-10a-penta-methyl-3-vinyl-dodeca-hydro-1h-benzo-f-chromen-9-ol-isolated-from-sideritis-perfoliata
#19
Ísmail Çelik, Cem Cüneyt Ersanlı, Rahmi Köseoğlu, Hüseyin Akşit, Ramazan Erenler, Ibrahim Demirtaş, Mehmet Akkurt
The asymmetric unit of the title compound, C20H34O2, contains two crystallographically independent mol-ecules (1 and 2) with similar conformations. In both mol-ecules, the cyclo-hexane rings adopt a chair conformation, while the oxane rings are also puckered. In the crystal, O-H⋯O hydrogen bonds connect adjacent mol-ecules, forming C(6) helical chains located around a 21 screw axis and running along the crystallographic a axis. The packing of these chains is governed only by van der Waals inter-actions. Semi-empirical PM3 quantum chemical calculations are in a satisfactory agreement with the structural results of the X-ray structure analysis...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27598979/body-composition-resting-energy-expenditure-and-inflammatory-markers-impact-in-users-of-depot-medroxyprogesterone-acetate-after-12-months-follow-up
#20
Gisele Almeida Batista, Aglécio Luiz de Souza, Daniela Miguel Marin, Marina Sider, Vaneska Carvalho Melhado, Arlete Maria Fernandes, Sarah Monte Alegre
Objective: The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods: Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed...
January 2017: Archives of Endocrinology and Metabolism
keyword
keyword
28435
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"