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https://www.readbyqxmd.com/read/29623520/cgrp-monoclonal-antibodies-for-the-preventative-treatment-of-migraine
#1
REVIEW
Heike Israel, Lars Neeb, Uwe Reuter
PURPOSE OF REVIEW: CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have been developed and are currently under investigation for episodic (EM) and chronic migraine (CM) prevention. Here, we report data from these clinical trials. RECENT FINDINGS: Placebo-controlled, randomized double-blind phase studies of CGRP mAbs in episodic and chronic migraine have shown that the specific blockade of the peptide or the CGRP receptor are both powerful mechanisms to reduce migraine frequency...
April 6, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29603188/linking-tree-genetics-and-stream-consumers-isotopic-tracers-elucidate-controls-on-carbon-and-nitrogen-assimilation
#2
Zacchaeus G Compson, Bruce A Hungate, Thomas G Whitham, George W Koch, Paul Dijkstra, Adam C Siders, Todd Wojtowicz, Ryan Jacobs, David N Rakestraw, Kiel E Allred, Chelsea K Sayer, Jane C Marks
Leaf litter provides an important nutrient subsidy to headwater streams, but little is known about how tree genetics influences energy pathways from litter to higher trophic levels. Despite the charge to quantify carbon (C) and nitrogen (N) pathways from decomposing litter, the relationship between litter decomposition and aquatic consumers remains unresolved. We measured litter preference (attachments to litter), C and N assimilation rates, and growth rates of a shredding caddisfly (Hesperophylax magnus, Limnephilidae) in response to leaf litter of different chemical and physical phenotypes using Populus cross types (P...
March 30, 2018: Ecology
https://www.readbyqxmd.com/read/29582973/transforaminal-percutaneous-endoscopic-lumbar-discectomy-outcome-and-complications-in-270-cases
#3
Leonello Tacconi, Sara Baldo, Giorgio Merci, Gerardo Serra
BACKGROUND: The endoscopic approach has been introduced in the clinical practice in 1980 with the aim to remove the pro- lapsed disk and free the compressed nerve using the least disruptive surgical technique, assuring in the same time, the resolution of the symptoms and a faster return back to normal life activity. Over the years, thanks to an extraordinary technical improvement either in terms of quality of images and development of many dif- ferent tailored instrumentations there has been a huge spreading of the endoscope use across the different surgical fields...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29521225/role-of-haematopoietic-stem-cell-transplantation-in-management-of-severe-chronic-neutropenia
#4
Francesca Fioredda
The inherited form of Severe Chronic Neutropenia called Severe Congenital Neutropenia (SCN) is an intrinsic defect of neutrophils maturation. SCN affected patients are at risk to develop lethal in-fections and to transform into myelodisplasia (MDS) and/or acute laeukemia(AL). Use of Granulocyte-Colony-Stimulating Factor (G-CSF) has significantly improved the prognosis of affected patients, but the only definitive cure for the disease is Haematopoietic Stem Cell Trans-plantation (HSCT). Overall Survival of SCN patients has been assessed at around 85% after 3 years from transplantation ...
March 8, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29494708/a-hierarchical-anatomical-classification-schema-for-prediction-of-phenotypic-side-effects
#5
Somin Wadhwa, Aishwarya Gupta, Shubham Dokania, Rakesh Kanji, Ganesh Bagler
Prediction of adverse drug reactions is an important problem in drug discovery endeavors which can be addressed with data-driven strategies. SIDER is one of the most reliable and frequently used datasets for identification of key features as well as building machine learning models for side effects prediction. The inherently unbalanced nature of this data presents with a difficult multi-label multi-class problem towards prediction of drug side effects. We highlight the intrinsic issue with SIDER data and methodological flaws in relying on performance measures such as AUC while attempting to predict side effects...
2018: PloS One
https://www.readbyqxmd.com/read/29490008/a-global-network-of-biomedical-relationships-derived-from-text
#6
Bethany Percha, Russ B Altman
Motivation: The biomedical community's collective understanding of how chemicals, genes, and phenotypes interact is distributed across the text of over 24 million research articles. These interactions offer insights into the mechanisms behind higher order biochemical phenomena, such as drug-drug interactions and variations in drug response across individuals. To assist their curation at scale, we must understand what relationship types are possible and map unstructured natural language descriptions onto these structured classes...
February 27, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29415748/an-ethnobotanical-study-in-midyat-turkey-a-city-on-the-silk-road-where-cultures-meet
#7
Ali Akgul, Ayfer Akgul, Serdar G Senol, Hasan Yildirim, Ozcan Secmen, Yunus Dogan
BACKGROUND: Studies of ethnobotanical usages in south-eastern Turkey are rare. To widen this field of knowledge, we conducted an ethnobotanical study in Midyat (Mardin Province), Turkey. METHODS: The field study was completed during three years (2007-2010). Our aim was to document the ethnobotanical uses of local plants and to make an ethnobotanical inventory of uncommon plants using qualitative interviews. RESULTS: During field studies, 368 voucher specimens were collected in the investigated area...
February 7, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29408783/incorporation-of-prior-knowledge-of-signal-behavior-into-the-reconstruction-to-accelerate-the-acquisition-of-diffusion-mri-data
#8
Juan F P J Abascal, Manuel Desco, Juan Parra-Robles
Diffusion MRI data are generally acquired using hyperpolarized gases during patient breath-hold, which yields a compromise between achievable image resolution, lung coverage, and number of -values. In this paper, we propose a novel method that accelerates the acquisition of diffusion MRI data by undersampling in both the spatial and -value dimensions and incorporating knowledge about signal decay into the reconstruction (SIDER). SIDER is compared with total variation (TV) reconstruction by assessing its effect on both the recovery of ventilation images and the estimated mean alveolar dimensions (MADs)...
February 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29383630/shmuel-malkin-1934-2017-listening-to-photosynthesis-and-making-music
#9
Stephen K Herbert, Yona Siderer, Govindjee
We present here the life and work of Shmuel Malkin (1934-2017), an accomplished scientist and a gifted musician who touched the lives of many around the world. His early scientific work addressed the dynamics of light harvesting and electron transport in photosynthesis. Later, he used photoacoustic and photothermal methodologies to explore all aspects of photosynthesis. As a musician, Shmuel played the piano often for family and friends but after his formal retirement, he produced a body of original musical compositions, many of which were performed publicly...
January 30, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29368877/transperitoneal-laparoscopic-pyeloplasty-in-children-does-upper-urinary-tract-anomalies-affect-surgical-outcomes
#10
João Arthur Brunhara, Paulo Renato Marcelo Moscardi, Marcos Figueiredo Mello, Hiury Silva Andrade, Paulo Afonso Carvalho, Bruno Nicolino Cezarino, Francisco Tibor Dénes, Roberto Iglesias Lopes
OBJECTIVE: to assess the feasibility and outcomes of laparoscopic pyeloplasty in children with complex ureteropelvic junction obstruction (UPJO) and compare to children with iso-lated UPJO without associated urinary tract abnormalities. MATERIAL AND METHODS: Medical records of 82 consecutive children submitted to transperitoneal laparoscopic pyeloplasty in a 12-year period were reviewed. Eleven cases were con-sidered complex, consisting of atypical anatomy including horseshoe kidneys in 6 patients, pelvic kidneys in 3 patients, and a duplex collecting system in 2 patients...
January 26, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29329243/characteristics-of-beidou-navigation-satellite-system-multipath-and-its-mitigation-method-based-on-kalman-filter-and-rauch-tung-striebel-smoother
#11
Qiuzhao Zhang, Wei Yang, Shubi Zhang, Xin Liu
Global Navigation Satellite System (GNSS) carrier phase measurement for short baseline meets the requirements of deformation monitoring of large structures. However, the carrier phase multipath effect is the main error source with double difference (DD) processing. There are lots of methods to deal with the multipath errors of Global Position System (GPS) carrier phase data. The BeiDou navigation satellite System (BDS) multipath mitigation is still a research hotspot because the unique constellation design of BDS makes it different to mitigate multipath effects compared to GPS...
January 12, 2018: Sensors
https://www.readbyqxmd.com/read/29178783/heterogeneous-catalysis-on-demand-mechanically-controlled-catalytic-activity-of-a-metal-surface
#12
Tomasz Mazur, Slawomir Lach, Bartosz A Grzybowski
A metal surface passivated with a tightly packed self-assembled monolayer (SAM) can be made catalytically active upon the metal's mechanical deformation. This deformation renders the SAM sparser and exposes additional catalytic sites on the metal's surface. If the deformation is elastic, return of the metal to the original shape "heals" the SAM and nearly extinguishes the catalytic activity. Kelvin probe force microscopy and theoretical considerations both indicate that the catalytic domains "opening up" in the deformed SAM are of nanoscopic dimensions...
December 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29108538/-upper-abdominal-pain-caused-by-oesophageal-perforation
#13
EDITORIAL
Bastian Neesgaard, Anne-Sophie Sejling, Lene Arguimbau Ostenfeld-Møller
Boerhaave's syndrome or spontaneous oesophageal perforation is associated with significant mortality de-pending on time of diagnosis and initiation of treatment. However, the diagnosis is often delayed, as the condition mimics more frequent causes of chest- and abdominal pain. This case report describes a patient with severe upper ab-dominal and back pain following ructus in an effort to loosen a piece of candy stuck in the oesophagus. The case demon-strates, that Boerhaave's syndrome should always be con-sidered in patients presenting with acute chest- or upper abdominal pain...
November 6, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29106964/simulated-molecular-scale-interaction-of-supercritical-fluid-mobile-and-stationary-phases
#14
Paul D Siders
In supercritical fluid chromatography, molecules from the mobile phase adsorb on the stationary phase. Stationary-phase alkylsilane-terminated silica surfaces might adsorb molecules at the silica, among the silanes, on a silane layer, or in pore space between surfaces. Mobile phases of carbon dioxide, pure and modified with methanol, and stationary phases were simulated at the molecular scale. Classical atomistic force fields were used in Gibbs-ensemble hybrid Monte Carlo calculations. Excess adsorption of pure carbon dioxide mobile phase peaked at fluid densities of 0...
December 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29055735/sucrosomial%C3%A2-iron-absorption-studied-by-in-vitro-and-ex-vivo-models
#15
Angela Fabiano, Elisa Brilli, Stefano Fogli, Denise Beconcini, Sara Carpi, Germano Tarantino, Ylenia Zambito
This paper presents a comparative evaluation of different oral ferric iron formulations for ability to retain Fe3+ in simulated gastric fluid (SGF), be internalized by cells lining intestinal epithelium, and cross it to reach the bloodstream. In all formulations iron was ferric pyrophosphate, the excipients were different types and fractions of lecithin plus sucrose esters of fatty acids matrix (Sideral® RM; PRT1; PRT2) or lecithin without sucrester (SUN). Dissolution kinetics of formulations in SGF was studied by USP method...
January 1, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030039/effect-of-acidic-and-enzymatic-pretreatment-on-the-analysis-of-mountain-tea-sideritis-spp-volatiles-via-distillation-and-ultrasound-assisted-extraction
#16
Virginia D Dimaki, Gregoris Iatrou, Fotini N Lamari
A number of beneficial medicinal properties are attributed to the extract and essential oil of the aerial parts of Sideritis species (Lamiaceae). Hydrodistillation of the aerial parts of wild Sideritis clandestina ssp. peloponnesiaca (an endemic taxon in northern Peloponnesus, Greece) gave a low essential oil yield (<0.12%); about 65 components, mainly α-pinene, β-caryophyllene, β-pinene, globulol, caryophyllene oxide, were identified via GC-MS. Internal and external standards were used for quantification...
November 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28927300/sideritis-romana-l-subsp-purpurea-tal-ex-benth-heywood-a-new-chemotype-from-montenegro
#17
Stefania Garzoli, Mijat Božović, Anna Baldisserotto, Elisa Andreotti, Federico Pepi, Vanja Tadić, Stefano Manfredini, Rino Ragno
A study on essential oil fractions of the Western Balkan endemic Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood collected in Montenegro is reported. The 24-h systematic steam distillation extraction procedure was performed. The gas chromatographic/mass spectrometric (GC/MS) analysis of the fractions showed γ-elemene and spathulenol as two main constituents, revealing a new chemotype of this plant species. Although varying in the content of these two main compounds, which makes the fractions quite different between each other, evaluation of the anti-Candida activity showed the lack of any significant efficacy...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28902140/iron-absorption-from-three-commercially-available-supplements-in-gastrointestinal-cell-lines
#18
Francesca Uberti, Vera Morsanuto, Sabrina Ghirlanda, Claudio Molinari
This study compares the absorption characteristics of two iron-based dietary supplements and their biocompatibility to bisglycinate iron, a common chelated iron form. The Caco-2 cell line-a model of human intestinal absorption-and GTL-16 cell line-a model of gastric epithelial cells-were used to perform the experiments; in the first experiments, the kinetics of absorption have been evaluated analyzing the divalent metal transporter 1 (DMT1) expression. Three different iron combinations containing 50 µM iron (named Fisioeme(®), Sideral(®) and bisglycinate) were used for different stimulation times (1-24 h)...
September 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28880089/pickering-membranes-stabilized-by-saturn-particles
#19
Matthias M Krejca, Cornell Wüstner, Werner A Goedel
We report on a novel method to synthesize particles-called by us Saturn particles-having two hydrophobic caps that oppose each other and are separated from each other by a hydrophilic belt that encircles the particle. Mixtures of these particles with water and air, without the usage of low molar mass surfactants, easily form Pickering foams and Pickering membranes that are stable for days. These Pickering membranes are composed of a thin film of water into which the particles are embedded in such a way that the belt is surrounded by the water and the caps protrude out of the water into the air at the top and bottom side of the water film...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28877997/the-pumilio-domain-protein-puf6-contributes-to-sider2-retroposon-mediated-mrna-decay-in-leishmania
#20
Hiva Azizi, Carole Dumas, Barbara Papadopoulou
Leishmania and other trypanosomatid protozoa lack control at the level of transcription initiation and regulate gene expression exclusively post-transcriptionally. We have reported previously that Leishmania harbors a unique class of<u>s</u>hort<u>i</u>nterspersed<u>de</u>generate<u>r</u>etroposons (SIDERs) that are predominantly located within 3'UTRs and play a major role in post-transcriptional control. We have shown that members of the SIDER2 subfamily initiate mRNA decay through endonucleolytic cleavage within the second conserved 79-nt signature sequence of SIDER2 retroposons...
December 2017: RNA
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