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https://www.readbyqxmd.com/read/28495341/estimation-of-the-prevalence-of-adverse-drug-reactions-from-social-media
#1
Thin Nguyen, Mark E Larsen, Bridianne O'Dea, Dinh Phung, Svetha Venkatesh, Helen Christensen
This work aims to estimate the degree of adverse drug reactions (ADR) for psychiatric medications from social media, including Twitter, Reddit, and LiveJournal. Advances in lightning-fast cluster computing was employed to process large scale data, consisting of 6.4 terabytes of data containing 3.8 billion records from all the media. Rates of ADR were quantified using the SIDER database of drugs and side-effects, and an estimated ADR rate was based on the prevalence of discussion in the social media corpora...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28454548/effective-communication-of-public-health-guidance-to-emergency-department-clinicians-in-the-setting-of-emerging-incidents-a-qualitative-study-and-framework
#2
Yasmin Khan, Sarah Sanford, Doug Sider, Kieran Moore, Gary Garber, Eileen de Villa, Brian Schwartz
BACKGROUND: Evidence to inform communication between emergency department clinicians and public health agencies is limited. In the context of diverse, emerging public health incidents, communication is urgent, as emergency department clinicians must implement recommendations to protect themselves and the public. The objectives of this study were to: explore current practices, barriers and facilitators at the local level for communicating public health guidance to emergency department clinicians in emerging public health incidents; and develop a framework that promotes effective communication of public health guidance to clinicians during emerging incidents...
April 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28433576/proptosis-and-vision-loss-as-grave-complications-of-allergic-fungal-sinusitis-and-polyposis
#3
Shane A Bobart, Ves Dimov, Darby Sider, Esteban Gallego
No abstract text is available yet for this article.
April 19, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28408735/predicting-neurological-adverse-drug-reactions-based-on-biological-chemical-and-phenotypic-properties-of-drugs-using-machine-learning-models
#4
Salma Jamal, Sukriti Goyal, Asheesh Shanker, Abhinav Grover
Adverse drug reactions (ADRs) have become one of the primary reasons for the failure of drugs and a leading cause of deaths. Owing to the severe effects of ADRs, there is an urgent need for the generation of effective models which can accurately predict ADRs during early stages of drug development based on integration of various features of drugs. In the current study, we have focused on neurological ADRs and have used various properties of drugs that include biological properties (targets, transporters and enzymes), chemical properties (substructure fingerprints), phenotypic properties (side effects (SE) and therapeutic indications) and a combinations of the two and three levels of features...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388386/life-after-breast-prostate-and-colon-cancer-primary-care-s-role
#5
REVIEW
Emily E Jonczak, Elizabeth R Stone, Cristina I Pravia, Darby Sider
When patients survive cancer, they eventually come back to their primary care physicians. This group has special needs, including surveillance for recurrent and new cancer, health promotion, and interventions to mitigate the lingering effects of the cancer and the adverse effects of its treatment.
April 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28387744/characteristics-of-the-bds-carrier-phase-multipath-and-its-mitigation-methods-in-relative-positioning
#6
Wujiao Dai, Qiang Shi, Changsheng Cai
The carrier phase multipath effect is one of the most significant error sources in the precise positioning of BeiDou Navigation Satellite System (BDS). We analyzed the characteristics of BDS multipath, and found the multipath errors of geostationary earth orbit (GEO) satellite signals are systematic, whereas those of inclined geosynchronous orbit (IGSO) or medium earth orbit (MEO) satellites are both systematic and random. The modified multipath mitigation methods, including sidereal filtering algorithm and multipath hemispherical map (MHM) model, were used to improve BDS dynamic deformation monitoring...
April 7, 2017: Sensors
https://www.readbyqxmd.com/read/28369040/phosphorylated-glycosphingolipids-essential-for-cholesterol-mobilization-in-caenorhabditis-elegans
#7
Sebastian Boland, Ulrike Schmidt, Vyacheslav Zagoriy, Julio L Sampaio, Raphael F Fritsche, Regina Czerwonka, Tilo Lübken, Jakob Reimann, Sider Penkov, Hans-Joachim Knölker, Teymuras V Kurzchalia
The nematode Caenorhabditis elegans requires exogenous cholesterol to survive and its depletion leads to early developmental arrest. Thus, tight regulation of cholesterol storage and distribution within the organism is indispensable. Here, we present a novel class of C. elegans phosphorylated glycosphingolipids, phosphoethanolamine glucosylceramides (PEGCs), capable of rescuing larval arrest induced by sterol starvation. We describe the total synthesis of a major PEGC species and demonstrate that the PEGC synthetic counterpart suppresses the dauer-constitutive phenotype of Niemann-Pick C1 (NPC1) and DAF-7/TGF-β mutant worms caused by impaired intracellular sterol trafficking...
June 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#8
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28298238/biofed-federated-query-processing-over-life-sciences-linked-open-data
#9
Ali Hasnain, Qaiser Mehmood, Syeda Sana E Zainab, Muhammad Saleem, Claude Warren, Durre Zehra, Stefan Decker, Dietrich Rebholz-Schuhmann
BACKGROUND: Biomedical data, e.g. from knowledge bases and ontologies, is increasingly made available following open linked data principles, at best as RDF triple data. This is a necessary step towards unified access to biological data sets, but this still requires solutions to query multiple endpoints for their heterogeneous data to eventually retrieve all the meaningful information. Suggested solutions are based on query federation approaches, which require the submission of SPARQL queries to endpoints...
March 15, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28172976/p591-therapeutic-drug-monitoring-in-paediatric-inflammatory-bowel-disease-on-maintenance-infliximab-and-adalimumab-treatment-improves-clinical-remission-with-a-proactive-approach
#10
S Chadokufa, S Sider, B Huggett, T Sawney, N Shah, M Baycheva, A Zambrano Perez, N Acton, F Kiparissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172815/p579-complete-disease-resolution-after-allogenic-hematopoietic-stem-cell-transplantation-in-children-with-very-early-onset-inflammatory-disease-and-no-identified-monogenic-mutation
#11
A Zambrano Perez, M Elawad, F Kiparissi, N Shah, S Chadokufa, S Sider, B Huggett
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172769/p707-paediatric-ibd-patients-do-not-meet-the-daily-recommendations-of-vitamin-d-and-calcium-intake-survey-based-analysis-in-a-tertiary-centre
#12
R Shergill-Bonner, A Zambrano Perez, N Acton, S Chadokufa, B Huggett, F Kiparissi, M Baycheva, N Shah, S Sider
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172761/p479-shifting-the-shunters-in-a-paediatric-inflammatory-bowel-disease-population-thiopurine-dose-splitting-versus-allopurinol-and-thiopurine-co-therapy
#13
S Chadokufa, M Baycheva, T Sawney, N Acton, S Sider, N Shah, B Huggett, R Dziubak, F Kiparrissi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28094957/spatially-resolved-imaging-on-photocarrier-generations-and-band-alignments-at-perovskite-pbi2-heterointerfaces-of-perovskite-solar-cells-by-light-modulated-scanning-tunneling-microscopy
#14
Min-Chuan Shih, Shao-Sian Li, Cheng-Hua Hsieh, Ying-Chiao Wang, Hung-Duen Yang, Ya-Ping Chiu, Chia-Seng Chang, Chun-Wei Chen
The presence of the PbI2 passivation layers at perovskite crystal grains has been found to considerably affect the charge carrier transport behaviors and device performance of perovskite solar cells. This work demonstrates the application of a novel light-modulated scanning tunneling microscopy (LM-STM) technique to reveal the interfacial electronic structures at the heterointerfaces between CH3NH3PbI3 perovskite crystals and PbI2 passivation layers of individual perovskite grains under light illumination. Most importantly, this technique enabled the first observation of spatially resolved mapping images of photoinduced interfacial band bending of valence bands and conduction bands and the photogenerated electron and hole carriers at the heterointerfaces of perovskite crystal grains...
January 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28087585/standard-based-comprehensive-detection-of-adverse-drug-reaction-signals-from-nursing-statements-and-laboratory-results-in-electronic-health-records
#15
Suehyun Lee, Jiyeob Choi, Hun-Sung Kim, Grace Juyun Kim, Kye Hwa Lee, Chan Hee Park, Jongsoo Han, Dukyong Yoon, Man Young Park, Rae Woong Park, Hye-Ryun Kang, Ju Han Kim
OBJECTIVE: We propose 2 Medical Dictionary for Regulatory Activities-enabled pharmacovigilance algorithms, MetaLAB and MetaNurse, powered by a per-year meta-analysis technique and improved subject sampling strategy. MATRIALS AND METHODS: This study developed 2 novel algorithms, MetaLAB for laboratory abnormalities and MetaNurse for standard nursing statements, as significantly improved versions of our previous electronic health record (EHR)-based pharmacovigilance method, called CLEAR...
January 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27993785/predict-drug-permeability-to-blood-brain-barrier-from-clinical-phenotypes-drug-side-effects-and-drug-indications
#16
Zhen Gao, Yang Chen, Xiaoshu Cai, Rong Xu
Motivation: Blood-Brain-Barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Central Nervous System (CNS). Determination of compound's permeability to BBB is prerequisite in CNS drug discovery. Existing computational methods usually predict drug BBB permeability from chemical structure and they generally apply to small compounds passing BBB through passive diffusion. As abundant information on drug side effects and indications has been recorded over time through extensive clinical usage, we aim to explore BBB permeability prediction from a new angle and introduce a novel approach to predict BBB permeability from drug clinical phenotypes (drug side effects and drug indications)...
March 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27976016/effect-of-activated-charcoal-on-the-developmental-patterns-polyphenolics-productivity-and-photosynthetic-activity-of-sideritis-scardica-in-vitro
#17
P Koleva, N Petrova, S Krumova, V Velikova, I Aneva, L Evstatieva, E Wolfram, K Danova
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27917720/ultrasound-promoted-synthesis-and-anticoagulant-activity-of-2-amino-4h-chromen-4-ylphosphonates
#18
Sarva Santhisudha, Tellamekala Sreekanth, Sudileti Murali, Bathal Vijaya Kumar, Meruva Anila Devi, Cirandur Suresh Reddy
BACKGROUND: One of the alarming difficulties in the field of hematology is the Coagulant disorders. Despite the availability of clinically proven existing anticoagulants, their limitations have prompted a continuous search for novel anticoagulants. OBJECTIVE: The primary objective of the study is to synthesize a series of 2-amino-4H-chromen-4-ylphosphonate derivatives and to test their anticoagulant activity depending on PT measurements con-sidering commercial heparin as positive control...
December 4, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27907064/nad-is-a-food-component-that-promotes-exit-from-dauer-diapause-in-caenorhabditis-elegans
#19
Mykola Mylenko, Sebastian Boland, Sider Penkov, Julio L Sampaio, Benoit Lombardot, Daniela Vorkel, Jean-Marc Verbavatz, Teymuras V Kurzchalia
The free-living soil nematode Caenorhabditis elegans adapts its development to the availability of food. When food is scarce and population density is high, worms enter a developmentally arrested non-feeding diapause stage specialized for long-term survival called the dauer larva. When food becomes available, they exit from the dauer stage, resume growth and reproduction. It has been postulated that compound(s) present in food, referred to as the "food signal", promote exit from the dauer stage. In this study, we have identified NAD+ as a component of bacterial extract that promotes dauer exit...
2016: PloS One
https://www.readbyqxmd.com/read/27894370/-aut-sider-the-invisible-talent-of-simona-concaro%C3%A2
#20
L Fusar-Poli, M Rocchetti, M Garda, P Politi
No abstract text is available yet for this article.
April 2017: Epidemiology and Psychiatric Sciences
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