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Mykola Mylenko, Sebastian Boland, Sider Penkov, Julio L Sampaio, Benoit Lombardot, Daniela Vorkel, Jean-Marc Verbavatz, Teymuras V Kurzchalia
The free-living soil nematode Caenorhabditis elegans adapts its development to the availability of food. When food is scarce and population density is high, worms enter a developmentally arrested non-feeding diapause stage specialized for long-term survival called the dauer larva. When food becomes available, they exit from the dauer stage, resume growth and reproduction. It has been postulated that compound(s) present in food, referred to as the "food signal", promote exit from the dauer stage. In this study, we have identified NAD+ as a component of bacterial extract that promotes dauer exit...
2016: PloS One
L Fusar-Poli, M Rocchetti, M Garda, P Politi
No abstract text is available yet for this article.
November 29, 2016: Epidemiology and Psychiatric Sciences
Ryan Eshleman, Rahul Singh
BACKGROUND: Adverse drug events (ADEs) constitute one of the leading causes of post-therapeutic death and their identification constitutes an important challenge of modern precision medicine. Unfortunately, the onset and effects of ADEs are often underreported complicating timely intervention. At over 500 million posts per day, Twitter is a commonly used social media platform. The ubiquity of day-to-day personal information exchange on Twitter makes it a promising target for data mining for ADE identification and intervention...
October 6, 2016: BMC Bioinformatics
Ísmail Çelik, Cem Cüneyt Ersanlı, Rahmi Köseoğlu, Hüseyin Akşit, Ramazan Erenler, Ibrahim Demirtaş, Mehmet Akkurt
The asymmetric unit of the title compound, C20H34O2, contains two crystallographically independent mol-ecules (1 and 2) with similar conformations. In both mol-ecules, the cyclo-hexane rings adopt a chair conformation, while the oxane rings are also puckered. In the crystal, O-H⋯O hydrogen bonds connect adjacent mol-ecules, forming C(6) helical chains located around a 21 screw axis and running along the crystallographic a axis. The packing of these chains is governed only by van der Waals inter-actions. Semi-empirical PM3 quantum chemical calculations are in a satisfactory agreement with the structural results of the X-ray structure analysis...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
Gisele Almeida Batista, Aglécio Luiz de Souza, Daniela Miguel Marin, Marina Sider, Vaneska Carvalho Melhado, Arlete Maria Fernandes, Sarah Monte Alegre
Objective: The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods: Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed...
September 5, 2016: Archives of Endocrinology and Metabolism
Francesca Parisi, Cristiana Berti, Chiara Mandò, Anna Martinelli, Cristina Mazzali, Irene Cetin
PURPOSE: Iron supplementation is associated with side effects and overload risk. We compared different regimens of iron supplementation on maternal hematological status and pregnancy outcome in a cohort of healthy pregnant women. MATERIALS AND METHODS: Eighty non-anemic women with a normal singleton pregnancy were recruited at 11-13 weeks and randomized into controls (C; n = 20) and groups supplemented with ferrous iron 30 mg (FI; n = 20), liposomal iron 14 mg (Sideral® Pharmanutra, Pisa PI, Italy) (LI14; n = 20) and liposomal iron 28 mg/daily (LI28; n = 20) up to 6 weeks post-partum...
September 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
Cheng Lu, Gerhard Stock, Volker Knecht
A local perturbation of a protein may lead to functional changes at some distal site, a phenomenon denoted as allostery. Here we study the allosteric control of a protease using molecular dynamics simulations. The system considered is the bacterial protein DegS which includes a protease domain activated upon ligand binding to an adjacent PDZ domain. Starting from crystallographic structures of DegS homo-trimers, we perform simulations of the ligand-free and -bound state of DegS at equilibrium. Con- sidering a single protomer only, the trimeric state was mimicked by applying restraints on the residues in contact with other protomers in the DegS trimer...
August 24, 2016: Proteins
Alessandro Venditti, Armandodoriano Bianco, Claudio Frezza, Mauro Serafini, Ginevra Giacomello, Claudia Giuliani, Massimo Bramucci, Luana Quassinti, Giulio Lupidi, Domenico Lucarini, Fabrizio Papa, Filippo Maggi
Sideritis montana subsp. montana is a small annual herb occurring in countries bordering the Mediterranean and Balkan regions. The secondary metabolism of this plant has not been fully explored so far. The aim of the present study was to understand the complex mixture of secondary metabolites and the type of secretory structures. The polar constituents were isolated by column chromatography from the ethanolic extract, and their structure was elucidated by NMR and MS. The essential oil was isolated by hydrodistillation and analysed by GC/MS...
October 2016: Chemistry & Biodiversity
Mário Edson Santos de Sousa, Marcos Allan L dos Reis, Jordan Del Nero
In this paper, we present a study based on extended Hückel (ETH) and the Green function of the electron transport in a graphenenanoribbon with a nanopore oxidized in the middle. We con- sider several types of oxidation:hydroxyl, carboxyl and ketone groups adsorbed in edges, pore and surface of the riddon. The results indicate that nanoribbons with medium and high oxidation are more thermally stable than the low oxidation nanoribon that shows greater sensitivity at 120 °C. Finally, Ohmic and Negative Differential Resistance (NDR) were obtained from I(V) curves, thus was possible determine the current peaks and threshold voltages (V(Th1) < V(Th2) < V(Th3) < V(Th4)), which correspond to quantum transport of the nanoribbon not oxidized, high-oxy, med-oxy and low-oxy, respectively, so creating two nanoconstrictions as well as two regions of quantum confinement...
January 2016: Journal of Nanoscience and Nanotechnology
Sümeyye Sahin, Volker Eulenburg, Wolfgang Kreis, Carmen Villmann, Monika Pischetsrieder
Potentiation of γ-amino butyric acid (GABA)-induced GABAA receptor (GABAAR) activation is a common pathway to achieve sedative, sleep-enhancing, anxiolytic, and antidepressant effects. Presently, a three-component test system was established for the identification of novel GABAAR modulating food plants. In the first step, potentiation of GABA-induced response of the GABAAR was analysed by two-electrode voltage clamp (TEVC) for activity on human α1β2-GABAAR expressed in Xenopus laevis oocytes. Positively tested food plants were then subjected to quantification of GABA content by high-performance liquid chromatography with fluorescence detection (HPLC-FLD) to exclude test foods, which evoke a TEVC-response by endogenous GABA...
July 9, 2016: Plant Foods for Human Nutrition
Santiago Vilar, George Hripcsak
BACKGROUND: Drug-target identification is crucial to discover novel applications for existing drugs and provide more insights about mechanisms of biological actions, such as adverse drug effects (ADEs). Computational methods along with the integration of current big data sources provide a useful framework for drug-target and drug-adverse effect discovery. RESULTS: In this article, we propose a method based on the integration of 3D chemical similarity, target and adverse effect data to generate a drug-target-adverse effect predictor along with a simple leveraging system to improve identification of drug-targets and drug-adverse effects...
2016: Journal of Cheminformatics
Valeria Romanucci, Giovanni Di Fabio, Daniele D'Alonzo, Annalisa Guaragna, Giovanni Scapagnini, Armando Zarrelli
Sideritis species have been used in folk medicine for their antimicrobial, antiulcerogenic, digestive and anti-inflammatory properties. Over the years, the phytochemistry of the genus Sideritis has been studied, and various terpenoids, sterols, coumarins, and especially flavonoid aglycones and glycosides, have been identified. In particular, species from the Balkan Peninsula have been studied and found to be rich in flavonoids, with valuable antioxidant activity. In the folk medicine of the Balkan countries, Sideritis raeseri is used as an herbal tea in the treatment of inflammation, gastrointestinal disorders, and coughs and as a tonic, while extracts are used as a component of dietary supplements for anaemia...
June 25, 2016: Journal of the Science of Food and Agriculture
Corinne Blanchet-Collet, Aline Sider, Beatrice Gal, Mouna Hanachi-Guidoum, Jean-Claude Melchior, Didier Bouscary, Damien Ringuenet, Renaud de Tournemire, Marie Rose Moro
No abstract text is available yet for this article.
September 2016: Eating and Weight Disorders: EWD
Johannes van Brederode, Sinem Atak, Artur Kessler, Monika Pischetsrieder, Carmen Villmann, Christian Alzheimer
Sideritis plants and their extracts have been used in traditional medicine as sedatives, anxiolytics and anticonvulsant agents. Pinenes are the most prevalent of the volatile aroma components in Siderites extracts and the pinene metabolites myrtenol and verbenol have been identified as the most potent positive allosteric modulators of synaptic GABAA receptors composed of α1β2 and α1β2γ2 subunits. In view of their therapeutic spectrum, we wondered whether these two terpenoids would also augment tonic GABA currents mediated by extrasynaptic GABAA receptors containing the δ subunit...
August 15, 2016: Neuroscience Letters
Jochen Kammermeier, Robert Dziubak, Matilde Pescarin, Suzanne Drury, Heather Godwin, Kate Reeve, Sibongile Chadokufa, Bonita Huggett, Sara Sider, Chela James, Nikki Acton, Elena Cernat, Marco Gasparetto, Gabi Noble-Jamieson, Fevronia Kiparissi, Mamoun Elawad, Phil L Beales, Neil J Sebire, Kimberly Gilmour, Holm H Uhlig, Chiara Bacchelli, Neil Shah
OBJECTIVES: Inflammatory bowel disease [IBD] presenting in early childhood is extremely rare. More recently, progress has been made to identify children with monogenic forms of IBD predominantly presenting very early in life. In this study, we describe the heterogeneous phenotypes and genotypes of patients with IBD presenting before the age of 2 years and establish phenotypic features associated with underlying monogenicity. METHODS: Phenotype data of 62 children with disease onset before the age of 2 years presenting over the past 20 years were reviewed...
June 14, 2016: Journal of Crohn's & Colitis
Tiffany I Leung, Michel Dumontier
BACKGROUND: Clinical practice guidelines (CPGs) recommend pharmacologic treatments for clinical conditions, and drug structured product labels (SPLs) summarize approved treatment indications. Both resources are intended to promote evidence-based medical practices and guide clinicians' prescribing decisions. However, it is unclear how well CPG recommendations about pharmacologic therapies match SPL indications for recommended drugs. In this study, we perform text mining of CPG summaries to examine drug-disease associations in CPG recommendations and in SPL treatment indications for 15 common chronic conditions...
2016: Journal of Biomedical Semantics
Jacqueline Hofrichter, Markus Krohn, Toni Schumacher, Cathleen Lange, Bjöorn Feistel, Bernd Walbroel, Jens Pahnke
Nowadays, Alzheimer's disease is the most prevalent epiphenomenon of the aging population. Although soluble amyloid-β (Aβ) species (monomers, oligomers) are recognized triggers of the disease, no therapeutic approach is able to stop it. Herbal medicines are used to treat different diseases in many regions of the world. On the Balkan Peninsula, at the eastern Mediterranean Sea, and adjacent regions, Sideritis species are used as traditional medicine to prevent age-related problems in elderly. To evaluate this traditional knowledge in controlled experiments, we tested extracts of two commonly used Sideritis species, Sideritis euboea and Sideritis scardica, with regard to their effects on cognition in APP-transgenic and aged, non-transgenic C57Bl/6 mice...
May 31, 2016: Journal of Alzheimer's Disease: JAD
Mark P Nelder, Curtis B Russell, Nina Jain Sheehan, Beate Sander, Stephen Moore, Ye Li, Steven Johnson, Samir N Patel, Doug Sider
BACKGROUND: The blacklegged tick Ixodes scapularis transmits Borrelia burgdorferi (sensu stricto) in eastern North America; however, the agent of Lyme disease is not the sole pathogen harbored by the blacklegged tick. The blacklegged tick is expanding its range into areas of southern Canada such as Ontario, an area where exposure to blacklegged tick bites and tick-borne pathogens is increasing. We performed a systematic review to evaluate the public health risks posed by expanding blacklegged tick populations and their associated pathogens...
2016: Parasites & Vectors
Kyle D Flack, William A Siders, LuAnn Johnson, James N Roemmich
BACKGROUND: Resting metabolic rate (RMR) measurement is time consuming and requires specialized equipment. Prediction equations provide an easy method to estimate RMR; however, their accuracy likely varies across individuals. Understanding the factors that influence the accuracy of RMR predictions will help to revise existing, or develop new and improved, equations. OBJECTIVE: Our aim was to test the validity of RMR predicted in healthy adults by the Harris-Benedict, World Health Organization, Mifflin-St Jeor, Nelson, Wang equations, and three meta-equations of Sabounchi...
September 2016: Journal of the Academy of Nutrition and Dietetics
Ruwandi Kariyawasam, Rachel Lau, Alireza Eshaghi, Samir N Patel, Doug Sider, Jonathan B Gubbay, Andrea K Boggild
Malaria is the most common specific cause of fever in returning travelers, but many other vectorborne infections and viral infections are emerging and increasingly encountered by travelers. We documented common and emerging viral pathogens in malaria-negative specimens from ill travelers returning to Canada. Anonymized, malaria-negative specimens were examined for various viral pathogens by real-time PCR. Samples were positive for herpes simplex viruses 1 or 2 (n = 21, 1.6%), cytomegalovirus (n = 4, 0.3%), Epstein-Barr virus (n = 194, 14...
May 2016: Emerging Infectious Diseases
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