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https://www.readbyqxmd.com/read/29022211/subjective-global-nutritional-assessment-a-reliable-screening-tool-for-nutritional-assessment-in-cerebral-palsy-children
#1
Priyanka Minocha, Sadasivan Sitaraman, Anita Choudhary, Rajiv Yadav
OBJECTIVE: To determine the prevalence of undernutrition in children with cerebral palsy and to compare subjective and objective methods of nutritional assessment. METHODS: This was a hospital based analytical observational study in which 180 children of cerebral palsy, aged 1-12 y, attending tertiary level hospital, Jaipur from March, 2012 through March, 2013 were included. Subjective assessment was done by questionnaire (Subjective Global Nutritional Assessment; SGNA) in which questions related to nutrition history and physical examination, signs of fat, muscle wasting and edema was done while objective assessment was done by weight, height and triceps skinfold thickness (TSFT) measurements...
October 12, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28992629/%C3%AE-lipoic-acid-promotes-neurological-recovery-after-ischemic-stroke-by-activating-the-nrf2-ho-1-pathway-to-attenuate-oxidative-damage
#2
Chengmei Lv, Surendra Maharjan, Qingqing Wang, Yongxin Sun, Xu Han, Shan Wang, Zhengchun Mao, Yanming Xin, Bing Zhang
BACKGROUND/AIMS: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying mechanisms of α-LA. METHODS: In vivo study, α-LA was administered intravenously upon reperfusion of transient middle cerebral artery occlusion. Garcia score was used to evaluate neurologic recovery. Infarct volume was examined by TTC staining, and oxidative damage was evaluated by ELISA assay...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28987827/surgical-management-of-giant-intracranial-meningioma-operative-nuances-challenges-and-outcome
#3
Vinayak Narayan, Shyamal C Bir, Nasser Mohammed, Amey R Savardekar, Devi Prasad Patra, Anil Nanda
INTRODUCTION: The giant intracranial meningioma [GIM] constitutes a different spectrum of brain tumors which invade the vital neurovascular structures and makes the primary mode of treatment, surgery, a technically challenging one. The surgery of GIM is unique due to its large size, prominent vascularity, entangling and limited visualisation of various neurovascular structures and severe cerebral edema. The study reports the authors surgical experience of 80 GIM cases, the operative challenges and surgical outcome...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987262/acute-liver-failure
#4
REVIEW
Chalermrat Bunchorntavakul, K Rajender Reddy
Acute liver failure (ALF) is a life-threatening condition of heterogeneous etiology. Outcomes are better with early recognition and prompt initiation of etiology-specific therapy, intensive care protocols, and liver transplantation (LT). Prognostic scoring systems include the King's College Criteria and Model for End-stage Liver Disease score. Cerebral edema and intracranial hypertension are reasons for high morbidity and mortality; hypertonic saline is suggested for patients with a high risk for developing intracranial hypertension, and when it does, mannitol is recommended as first-line therapy...
November 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28987197/neuropathology-of-cerebrovascular-diseases
#5
Isidro Ferrer, Noemi Vidal
The chapter describes the epidemiology of cerebrovascular diseases, anatomy of the cerebral blood vessels, pathophysiology of ischemia, hypoxia, hypoxemia, anemic hypoxia, histotoxic hypoxia, carbon monoxide damage, hyperoxid brain damage and decompression sickness, and selective cell and regional vulnerability; diseases of the blood vessels including atherosclerosis, hypertensive angiopathy, small vessel disease, inflammatory vascular diseases, cerebral amyloid angiopathies, CADASIL, CARASIL and other diseases that can lead to cerebrovascular occlusion; intracranial and intraspinal aneurysms and vascular malformations; hematologic disorders that can cause cerebral infarct or hemorrhage; brain ischemic damage; and spontaneous intracranial bleeding...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28984162/acid-base-regulation-and-sensing-accelerators-and-brakes-in-metabolic-regulation-of-cerebrovascular-tone
#6
Ebbe Boedtkjer
Metabolic regulation of cerebrovascular tone directs blood flow to areas of increased neuronal activity and during disease states partially compensates for insufficient perfusion by enhancing blood flow in collateral blood vessels. Acid-base disturbances frequently occur as result of enhanced metabolism or insufficient blood supply, but despite definitive evidence that acid-base disturbances alter arterial tone, effects of individual acid-base equivalents and the underlying signaling mechanisms are still being debated...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28983815/the-association-between-fabp7-serum-levels-with-survival-and-neurological-complications-in-acetaminophen-induced-acute-liver-failure-a-nested-case-control-study
#7
Constantine J Karvellas, Jaime L Speiser, Mélanie Tremblay, William M Lee, Christopher F Rose
BACKGROUND: Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty acid-binding protein (FABP7) is a small (15 kDa) cytoplasmic protein abundantly expressed in astrocytes. The aim of this study was to determine whether serum FABP7 levels early (day 1) or late (days 3-5) level were associated with 21-day mortality and/or the presence of ICH/CE in APAP-ALF patients...
October 5, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28982595/transgenic-expression-of-hur-increases-vasogenic-edema-and-impedes-functional-recovery-in-rodent-ischemic-stroke
#8
Agnieszka A Ardelt, Randall S Carpenter, Ifeanyi Iwuchukwu, An Zhang, William Lin, Ewa Kosciuczuk, Cyrus Hinkson, Tania Rebeiz, Sydney Reitz, Peter H King
BACKGROUND AND PURPOSE: Ischemic stroke produces significant morbidity and mortality, and acute interventions are limited by short therapeutic windows. Novel approaches to neuroprotection and neurorepair are necessary. HuR is an RNA-binding protein (RBP) which modulates RNA stability and translational efficiency of genes linked to ischemic stroke injury. METHODS: Using a transgenic (Tg) mouse model, we examined the impact of ectopic HuR expression in astrocytes on acute injury evolution after transient middle cerebral artery occlusion (tMCAO)...
October 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28979829/hypertensive-encephalopathy-a-case-of-a-male-who-bit-off-his-fingers
#9
Carole H Kim, Saba Syed
Although altered consciousness and other neurologic manifestations are frequently seen in hypertensive encephalopathy, behavioral and psychotic symptoms are rarely seen. We describe a patient with no previous psychiatric history who was admitted for hypertensive crisis. A few days after admission, his blood pressure remained uncontrolled and he started to exhibit episodes of confusion, agitation, and psychosis. During one particular episode, he overcame multiple staff members and physical restraints to bite off two of his fingers without any signs of pain...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28974669/non-exertional-heatstroke-a-case-report-and-review-of-the-literature
#10
Chiara Mozzini, Giovanni Xotta, Ulisse Garbin, Anna Maria Fratta Pasini, Luciano Cominacini
BACKGROUND Heatstroke (HS) is a life-threatening condition characterized by an elevation of the core body temperature above 40°C, central nervous system dysfunction, and possible multi-organ failure. HS can trigger systemic inflammation, disseminated intravascular coagulation (DIC), rhabdomyolysis, cerebral edema and seizures, pulmonary edema, heart dysfunctions, and renal and hepatic failure. CASE REPORT We report the case of a 41-year-old Romanian woman with a history of alcoholism who developed HS after arriving by bus in Verona, Italy in June 2016...
October 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28973675/the-subarachnoid-hemorrhage-early-brain-edema-score-predicts-delayed-cerebral-ischemia-and-clinical-outcomes
#11
Sung-Ho Ahn, Jude P Savarraj, Mubashir Pervez, Wesley Jones, Jin Park, Sang-Beom Jeon, Sun U Kwon, Tiffany R Chang, Kiwon Lee, Dong H Kim, Arthur L Day, H Alex Choi
BACKGROUND: Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies of EBI is the lack of radiographic surrogate marker. OBJECTIVE: To propose a scoring system based on early changes in clinically obtained computed tomography (CT), called the Subarachnoid hemorrhage Early Brain Edema Score (SEBES). METHODS: Patients with spontaneous aneurysmal SAH and a CT within 24 h of ictus were included...
July 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28972114/teaching-neuroimages-typical-neuroimaging-features-in-high-altitude-cerebral-edema
#12
Victor Hugo Rocha Marussi, José Luiz Pedroso, Alexandre Maksoud Piccolo, Orlando G Barsottini, Fabiano Moulin de Moraes, Acary Souza Bulle Oliveira, Leonardo Furtado Freitas, Lázaro Luís Faria do Amaral
No abstract text is available yet for this article.
October 3, 2017: Neurology
https://www.readbyqxmd.com/read/28970705/characterization-of-cerebral-edema-in-acute-on-chronic-liver-failure
#13
Tarana Gupta, Radha K Dhiman, Chirag K Ahuja, Swastik Agrawal, Madhu Chopra, Naveen Kalra, Ajay Duseja, Sunil Taneja, Niranjan Khandelwal, Yogesh Chawla
BACKGROUND AND AIMS: The nature of cerebral edema in acute-on-chronic liver failure (ACLF) is not well studied. We aimed to characterize cerebral edema in ACLF using magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI). METHODS: Forty-six patients with cirrhosis and acute decompensation were included. Patients were divided into groups A (no cerebral failure, n = 39) and B (cerebral failure, n = 7). Group A was subdivided into no-ACLF (n = 11), grade 1 (n = 10), grade 2 (n = 9) and grade 3 (n = 9) ACLF as per CANONIC study...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28964774/delayed-2-h-post-stroke-administration-of-r18-and-na-1-tat-nr2b9c-peptides-after-permanent-and-or-transient-middle-cerebral-artery-occlusion-in-the-rat
#14
Diego Milani, Jane L Cross, Ryan S Anderton, David J Blacker, Neville W Knuckey, Bruno P Meloni
Following positive results with the poly-arginine peptide R18 when administered intravenously 30 or 60min after permanent and/or transient middle cerebral artery occlusion (MCAO; 90min) in the rat, we examined the effectiveness of the peptide when administered 2h after MCAO. R18 was administered intravenously (1000nmol/kg via jugular vein) after permanent MCAO or a transient 3-h MCAO or when administered intra-arterially (100nmol/kg via internal carotid artery) immediately after reperfusion following a transient 2-h MCAO...
September 28, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28954339/-concomitant-unruptured-intracranial-aneurysms-and-ischemic-cerebrovascular-diseases-a-surgical-experience-of-31-cases
#15
Y R Zheng, C Wu, H Zhang, Z Xue, H W Wang, Z H Sun
Objective: To summarize the clinic experience of preventing cerebral ischemic events during perioperative period in patients which concomitant unruptured intracranial aneurysms and ischemic cerebrovascular diseases. Methods: The clinical materials of 31 consecutive patients with concomitant unruptured intracranial aneurysms and ischemic cerebrovascular diseases from April 2010 to April 2014 were retrospectively reviewed.A total of 35 aneurysms were detected, and all of them were unruptured aneurysms.Among them, 17 cases were located on the ipsilateral side of artery stenosis or occlusion, and 18 cases were detected in the contralateral side...
September 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28953923/total-body-ct-and-mr-features-of-postmortem-change-in-in-hospital-deaths
#16
Ivo M Wagensveld, Britt M Blokker, Piotr A Wielopolski, Nomdo S Renken, Gabriel P Krestin, Myriam G Hunink, J Wolter Oosterhuis, Annick C Weustink
OBJECTIVES: To evaluate the frequency of total-body CT and MR features of postmortem change in in-hospital deaths. MATERIALS AND METHODS: In this prospective blinded cross-sectional study, in-hospital deceased adult patients underwent total-body postmortem CT and MR followed by image-guided biopsies. The presence of PMCT and PMMR features related to postmortem change was scored retrospectively and correlated with postmortem time interval, post-resuscitation status and intensive care unit (ICU) admittance...
2017: PloS One
https://www.readbyqxmd.com/read/28950851/the-ameliorative-effect-of-bloodletting-puncture-at-hand-twelve-jing-well-points-on-cerebral-edema-induced-by-permanent-middle-cerebral-ischemia-via-protecting-the-tight-junctions-of-the-blood-brain-barrier
#17
Nannan Yu, Zhenguo Wang, Yucen Chen, Juntao Yang, Xuan Lu, Yi Guo, Zelin Chen, Zhifang Xu
BACKGROUND: Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demonstrated the fact that bloodletting puncture at hand twelve Jing-well points (HTWP) could alleviate cerebral edema, which mainly results from the disruption of blood-brain barrier (BBB). The study, therefore, was first designed to demonstrate whether BBB-protection serves an important role in the edema-relief effect of HTWP bloodletting, based on which to research the molecular mechanism underlying...
September 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28945817/distribution-of-atherosclerotic-stenosis-determining-early-neurologic-deterioration-in-acute-ischemic-stroke
#18
Seung-Jae Lee, Dong-Geun Lee
BACKGROUND AND PURPOSE: Early neurologic deterioration (END) during the acute stage of stroke is clinically important because of its association with poor outcomes. The purpose of this study was (1) to investigate variables associated with END, (2) to determine the distribution of atherosclerotic stenosis associated with END, and (3) to clarify the relationship between END and clinical outcomes. METHODS: 516 patients with acute ischemic stroke were included. The median follow-up period was 31...
2017: PloS One
https://www.readbyqxmd.com/read/28944912/dhhp%C3%A2-6-attenuates-cerebral-ischemia%C3%A2-reperfusion-injury-in-rats-through-the-inhibition-of-apoptosis
#19
Yingshi Ji, Xin Yan, Yang Hu, Huan Xue, Jianfeng Sun, Huaqiu Chen, Jiayu Zhang, Liping Wang, Baigong Xue, Li Sun
As a novel reactive oxygen species (ROS) scavenger, deuterohemin His peptide‑6 (DhHP‑6) has been demonstrated to prolong the lifespan of Caenorhabditis elegans and has also exhibited protective effects in myocardial ischemia‑reperfusion injury. Whether similar effects occur during cerebral ischemia‑reperfusion (CIR) injury remains to be elucidated. The present study evaluated the function of DhHP‑6 and its underlying mechanisms in a middle cerebral artery occlusion (MCAO) model in rats. The focal transient MCAO model was implemented using the Longa method of ischemia for 2 h followed by reperfusion for 22 h in male Wistar rats...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944903/gpvi%C3%A2-fc%C3%A2-peg-improves-cerebral-infarct-volume-and-cerebral-thrombosis-in-mouse-model-with-cerebral-thrombosis
#20
Yimae Wufuer, Xuefeng Shan, Magaoweiya Sailike, Kamile Adilaimu, Songfeng Ma, Huguo Wang
Cerebral thrombosis is one of the most common causes of cerebral infarction, and anticoagulation therapy is a routine treatment in patients with hemorrhagic cerebral venous thrombosis. The hemostatic function of platelets is important for the anticoagulation therapy of thrombosis. Glycoprotein VI (GPVI) is reported as the major signaling receptor for collagen and is exclusively expressed on platelets and megakaryocytes, initiating platelet recruitment at sites of vascular injury and demonstrating numerous beneficial effects for patients with cerebral thrombosis...
September 20, 2017: Molecular Medicine Reports
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