keyword
MENU ▼
Read by QxMD icon Read
search

Cerebral edema

keyword
https://www.readbyqxmd.com/read/29929024/mri-features-in-solitary-cerebral-langerhans-cell-histiocytosis-a-case-report-and-review-of-literature
#1
Ju-Hwi Kim, Woo-Youl Jang, Tae-Young Jung, Kyung-Sub Moon, Shin Jung, Kyung-Hwa Lee, In-Young Kim
In this study, we report a case of solitary Langerhans cell histiocytosis (LCH) without skull or systemic lesions, including reviewing the initial magnetic resonance (MR) findings of cerebral LCH. A 36-year-old male patient presented with generalized tonic-clonic type seizure. Brain MR imaging showed a 3cm mass lesion involving the right frontal lobe. It showed iso-intensity on T1-weighted images and hyperintensity on T2-weighted images. After gadolinium enhancement, the mass showed heterogeneous enhancement with perilesional edema and additional adjacent leptomeningeal enhancement...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29928110/theaflavin-alleviates-inflammatory-response-and-brain-injury-induced-by-cerebral-hemorrhage-via-inhibiting-the-nuclear-transcription-factor-kappa-%C3%AE-related-pathway-in-rats
#2
Guanglei Fu, Hua Wang, Youli Cai, Hui Zhao, Wenjun Fu
Objective: Intracerebral hemorrhage (ICH) is one of the most common acute cerebrovascular diseases with high mortality. Numerous studies have shown that inflammatory response played an important role in ICH-induced brain injury. Theaflavin (TF) extracted from black tea has various biological functions including anti-inflammatory activity. In this study, we investigated whether TF could inhibit ICH-induced inflammatory response in rats and explored its mechanism. Materials and methods: ICH rat models were induced with type VII collagenase and pretreated with TF by gavage in different doses (25 mg/kg-100 mg/kg)...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29916544/yc%C3%A2-1-reduces-inflammatory-responses-by-inhibiting-nuclear-factor%C3%A2-%C3%AE%C2%BAb-translocation-in-mice-subjected-to-transient-focal-cerebral-ischemia
#3
Wei-Ting Lee, Shih-Huang Tai, Yu-Wen Lin, Tian-Shung Wu, E-Jian Lee
3‑(5‑hydroxymethyl‑2‑furyl)‑1‑benzyl‑indazole (YC‑1) is understood to protect against ischemic stroke, but the molecular basis for its neuroprotection remains to be fully characterized. The present study investigated the influence of YC‑1 on inflammatory responses following experimental stroke. Previous studies indicated that nuclear factor (NF)‑κB‑driven signals serve a pivotal role in mediating inflammatory responses following stroke. Ischemic stroke results in activation of NF‑κB to induce gene expression of factors including inducible nitric oxide synthase, interleukin (IL)‑1β, IL‑6 and matrix metalloproteinases (MMPs)...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29912262/-cerebral-tuberculosis-without-meningitis-in-a-immunocompetent-child
#4
Mónica Ramírez, Eduardo Cortés, José Betancur, Carlos Garcés
Cerebral tuberculosis TB (tuberculomas) without meningitis is an uncommon disease with a high morbidity and mortality. We report on a case that illustrates the complexity of this clinical presentation. An 11 month old, previously healthy male infant was brought to the clinic due to fever present during the last 1.5 months, associated with loss of neurodevelopmental goals and signs of endocranial hypertension. CT scan of the skull revealed dilatation of the ventricular system with transependimary edema; MRI showed multiple intra- and extra-axial micronodular images and hydrocephalus...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29910744/yangxue-qingnao-wan-and-silibinin-capsules-the-two-chinese-medicines-attenuate-cognitive-impairment-in-aged-ldlr-golden-syrian-hamsters-involving-protection-of-blood-brain-barrier
#5
You-Yu Gu, Ping Huang, Quan Li, Yu-Ying Liu, George Liu, Yu-Hui Wang, Ming Yi, Li Yan, Xiao-Hong Wei, Lei Yang, Bai-He Hu, Xin-Rong Zhao, Xin Chang, Kai Sun, Chun-Shui Pan, Yuan-Chen Cui, Qing-Fang Chen, Chuan-She Wang, Jing-Yu Fan, Zhi-Zhong Ma, Jing-Yan Han
The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29909454/inhibition-of-toll-like-receptor-4-tlr-4-improves-neurobehavioral-outcomes-after-acute-ischemic-stroke-in-diabetic-rats-possible-role-of-vascular-endothelial-tlr-4
#6
Yasir Abdul, Mohammed Abdelsaid, Weiguo Li, R Clinton Webb, Jennifer C Sullivan, Guangkuo Dong, Adviye Ergul
Diabetes increases the risk of occurrence and poor functional recovery after ischemic stroke injury. Previously, we have demonstrated greater hemorrhagic transformation (HT), edema, and more severe functional deficits after stroke in diabetic animals that also presented with cerebral vasoregression and endothelial cell death in the recovery period. Given that Toll-like receptor 4 (TLR-4) activation in microvascular endothelial cells triggers a robust inflammatory response, we hypothesized that inhibition of TLR-4 signaling prevents endothelial cell death and improves outcomes after stroke...
June 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29905566/-evaluation-of-neuroprotective-activity-of-complex-impact-of-magnesium-of-sulfate-lamotrygine-and-n-acetylcysteine-under-conditions-of-combined-normobaric-hypoxia-with-ligation-of-right-carotid-artery-in-rats
#7
M Samsonia, M Kandelaki, N Baratashvili
Cerebrovascular diseases of ischemic origin still remain the leading cause of death and disability of the population. In acute cerebral discirculation conditions, anaerobic glycolysis is activated, ATP formation rate decreases, the ion pumps work is disrupted and superoxide radicals are formed. Eventually, ionic asymmetry leads to the cytotoxic and vasogenic brain edema. Therefore, it is extremely important to induce simultaneous (complex) effect of medications on the key mechanisms of neuronal damage in process of survival of brain cells during acute ischemic stroke...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905016/examining-the-july-effect-on-patients-undergoing-pituitary-surgery
#8
Bassel Bashjawish, Shreya Patel, Suat Kılıç, Wayne D Hsueh, James K Liu, Soly Baredes, Jean Anderson Eloy
BACKGROUND: Our aim in this study was to assess the impact of the turnover of residents in July on patients undergoing pituitary surgery. METHODS: This work was a retrospective cohort study of cases from the National Inpatient Sample (NIS). Patients who underwent pituitary surgery from 2005 to 2012 were selected in the NIS. Patients undergoing surgery in July and in non-July months were compared to determine differences in demographics, comorbidities, and complications...
June 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29904091/naloxone-attenuates-ischemic-brain-injury-in-rats-through-suppressing-the-nik-ikk%C3%AE-nf-%C3%AE%C2%BAb-and-neuronal-apoptotic-pathways
#9
Xuan Wang, Zu-Jun Sun, Jun-Lu Wu, Wen-Qiang Quan, Wei-Dong Xiao, Helen Chew, Cui-Min Jiang, Dong Li
Although naloxone has been documented to exert neuroprotection in animal model of cerebral ischemia, the mechanism is not well understood. In this present study we investigated whether naloxone affected the mitochondrial apoptotic pathway in ischemic brain injury of rats. SD rats were subjected to a permanent middle cerebral artery occlusion surgery, and received naloxone (0.5, 1, 2 mg/kg, i.v.) immediately after ischemia. Neurological deficits were evaluated 24 h after ischemia using the McGraw Stroke Index, and then the rats were killed, and the brains were collected for further analyses...
June 14, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29900087/fulminant-herpes-simplex-virus-type-i-encephalitis-despite-maximal-medical-therapy
#10
Nakul Katyal, Ather M Taqui, Deborah Tepper, Jonathan M Beary, Christopher R Newey
Herpes simplex-1 virus encephalitis (HSE) is the most commonly recognized cause of sporadic encephalitis in the United States. Historically HSE has been considered extremely detrimental given the associated relentless neurological deterioration secondary to cerebral edema and status epilepticus. With recent advances in antiviral therapeutics in past decades, the majority of complications can be managed effectively although the associated morbidity and mortality still remains high. The key modifiable factor determining recovery is the rapid initiation of antiviral therapy...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29895352/direct-comparison-of-the-thioacetamide-and-azoxymethane-models-of-type-a-hepatic-encephalopathy-in-mice
#11
Stephanie Grant, Matthew McMillin, Gabriel Frampton, Anca D Petrescu, Elaina Williams, Victoria Jaeger, Jessica Kain, Sharon DeMorrow
Acute liver failure is a devastating consequence of hepatotoxic liver injury that can lead to the development of hepatic encephalopathy. There is no consensus on the best model to represent these syndromes in mice and therefore the aim of this study was to classify hepatic and neurological consequences of azoxymethane- and thioacetamide-induced liver injury. Azoxymethane-treated mice were euthanized at time points representing absence of, minor and significant stages of neurological decline. Thioacetamidetreated mice had tissue collected at up to 3 days following daily injections...
June 12, 2018: Gene Expression
https://www.readbyqxmd.com/read/29890916/arterial-spin-labeling-perfusion-prospective-mr-imaging-in-differentiating-neoplastic-from-non-neoplastic-intra-axial-brain-lesions
#12
Neetu Soni, Karthika Srindharan, Sunil Kumar, Prabhakar Mishra, Girish Bathla, Jyantee Kalita, Sanjay Behari
Purpose The purpose of this article is to assess the diagnostic performance of arterial spin-labeling (ASL) magnetic resonance perfusion imaging to differentiate neoplastic from non-neoplastic brain lesions. Material and methods This prospective study included 60 consecutive, newly diagnosed, untreated patients with intra-axial lesions with perilesional edema (PE) who underwent clinical magnetic resonance imaging including ASL sequences at 3T. Region of interest analysis was performed to obtain mean cerebral blood flow (CBF) values from lesion (L), PE and normal contralateral white matter (CWM)...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29886252/the-pathological-role-of-nlrs-and-aim2-inflammasome-mediated-pyroptosis-in-damaged-blood-brain-barrier-after-traumatic-brain-injury
#13
Xintong Ge, Wenzhu Li, Shan Huang, Zhenyu Yin, Xin Xu, Fanglian Chen, Xiaodong Kong, Haichen Wang, Jianning Zhang, Ping Lei
Pyroptosis is a highly specific type of inflammatory programmed cell death that different from necrosis or apoptosis. It is initiated by cellular detection of acute damage via recognizing pathogen-associated molecular patterns (PAMPs) by NOD-like receptors (NLRs) or AIM2-like receptor (AIM2). NLRs and AIM2 could trigger the formation of a multi-protein complex, known as inflammasome. It also contains apoptotic speck-containing protein (ASC) and pro-Caspase-1, and could process the signals to induce a cascade of inflammatory response...
June 7, 2018: Brain Research
https://www.readbyqxmd.com/read/29884521/nonaneurysmal-pseudo-subarachnoid-hemorrhage-computed-tomography-patterns-challenges-in-an-acute-decision-making-heuristics
#14
Tasneem F Hasan, Walter Duarte, Oluwaseun O Akinduro, Eric D Goldstein, Rebecca Hurst, Neil Haranhalli, David A Miller, Robert E Wharen, Rabih G Tawk, William D Freeman
BACKGROUND: Acute aneurysmal subarachnoid hemorrhage (SAH) is a medical and neurosurgical emergency from ruptured brain aneurysm. Aneurysmal SAH is identified on brain computed tomography (CT) as increased density of basal cisterns and subarachnoid spaces from acute blood products. Aneurysmal SAH-like pattern on CT appears as an optical illusion effect of hypodense brain parenchyma and/or hyperdense surrounding cerebral cisterns and blood vessels termed as "pseudo-subarachnoid hemorrhage" (pseudo-SAH)...
June 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29883817/manf-prevents-traumatic-brain-injury-in-rats-by-inhibiting-inflammatory-activation-and-protecting-blood-brain-barrier
#15
Qing-Xin Li, Yu-Xian Shen, Akhlaq Ahmad, Yu-Jun Shen, Yi-Quan Zhang, Pei-Kun Xu, Wei-Wei Chen, Yong-Qiang Yu
BACKGROUND: Our previous studies have shown that MANF provides neuroprotective effect against ischemia/reperfusion injury and is also involved in inflammatory disease models. This work investigates the potential role and mechanism of MANF in acute brain damage after traumatic brain injury (TBI). METHODS: The model of TBI was induced by Feeney free falling methods with male Sprauge-Dawley rats. The expression of MANF, 24 hrs after TBI, was detected by the immunohistochemistry, immunofluorescence, Western blot and Reverse transcription PCR(RT-PCR) techniques...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29883225/troxerutin-cerebroprotein-hydrolysate-injection-ameliorates-neurovascular-injury-induced-by-traumatic-brain-injury-via-endothelial-nitric-oxide-synthase-pathway-regulation
#16
Hóngyi Zhào, Yu Liu, Jing Zeng, Dandan Li, Yonghua Huang
BACKGROUND: Neurovascular dysfunction caused by Traumatic Brain Injury (TBI) is characterized by cerebralvascular damage, Blood-Brain Barrier (BBB) breakdown, brain edema, etc. The present study was designed to assess the protective role of 5 days Troxerutin Cerebroprotein Hydrolysate (TCH) injection treatment against TBI, as well as the potential mechanism. METHODS: The weight-drop model of TBI in male Sprague-Dawley rats was chosen to induce TBI model, rats either with TCH or a vehicle via intraperitoneal injection were examined 3rd after TBI...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29883008/transorbital-sonography-for-early-prognostication-of-hypoxic-ischemic-encephalopathy-after-cardiac-arrest
#17
Michael Ertl, Sarah Weber, Gertrud Hammel, Christoph Schroeder, Christos Krogias
BACKGROUND AND PURPOSE: Early prognostication of the outcome in resuscitated post cardiac arrest (CA) patients remains challenging especially if treated with therapeutic hypothermia. Brain edema caused by hypoxic-ischemic encephalopathy (HIE) can indirectly be estimated by transorbital sonography (TOS) taking in account the optic nerve sheath diameter (ONSD). The prognostic value of this easy, safe, and reproducible technique was investigated in this study. METHODS: A total of 49 patients, initially unconscious (Glasgow Coma Scale ≤6) after successful resuscitation, were enrolled into this prospective observational study...
June 8, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29882685/no-reflow-phenomenon-in-heart-and-brain
#18
Robert A Kloner, Kevin S King, Michael Harrington
The no-reflow phenomenon refers to the observation that when an organ is made ischemic by occlusion of a large artery supplying it, restoration of patency in that artery does not restore perfusion to the microvasculature supplying the parenchyma of that organ. This has been observed following prolonged arterial occlusions in the heart (30 to 90 minutes), brain, skin, and kidney. In experimental models, zones of no-reflow in the heart are characterized by ultrastructural microvascular damage, including focal endothelial swelling obstructing the lumen of small vessels...
June 8, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29882126/irisin-peptide-protects-brain-against-ischemic-injury-through-reducing-apoptosis-and-enhancing-bdnf-in-a-rodent-model-of-stroke
#19
Yasin Asadi, Fazel Gorjipour, Sedigheh Behrouzifar, Abedin Vakili
Evidence has shown therapeutic potential of irisin in cerebral stroke. The present study aimed to assess the effects of recombinant irisin on the infarct size, neurological outcomes, blood-brain barrier (BBB) permeability, apoptosis and brain-derived neurotrophic factor (BDNF) expression in a mouse model of stroke. Transient focal cerebral ischemia was established by middle cerebral artery occlusion (MCAO) for 45 min and followed reperfusion for 23 h in mice. Recombinant irisin was administrated at doses of 0...
June 7, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29882061/combined-treatment-approach-to-cerebral-arteriovenous-malformation-in-pediatric-patients-stereotactic-radiosurgery-to-partially-onyx-embolized-avm
#20
Daniel Umansky, Benjamin W Corn, Ido Strauss, Natan Shtraus, Shlomi Constantini, Vladimir Frolov, Shimon Maimon, Andrew A Kanner
PURPOSE: Treatment of cerebral arteriovenous malformations (AVM)-the most common cause of stroke in the pediatric population-can be challenging due to the complexity of size, morphology, and location. There is a significant risk in comparison to AVM treatment among adults. Thus, AVM treatment in the pediatric population imposes unique challenges. Recent improvements include optimized catheter techniques and better embolization materials, such as Onyx, a non-adhesive liquid embolic agent used in the adult population...
June 7, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
keyword
keyword
2843
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"