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https://www.readbyqxmd.com/read/28547033/assessing-colorectal-cancer-knowledge-among-puerto-rican-hispanics-implications-for-cancer-prevention-and-control
#1
Reinaldo Ramírez-Amill, Marievelisse Soto-Salgado, Carla Vázquez-Santos, Mónica Corzo-Pedrosa, Marcia Cruz-Correa
In Puerto Rico, colorectal cancer (CRC) incidence and mortality rates are increasing. Moreover, adherence rates to CRC screening (52.2%) are still below the goals (70.5%) established by Healthy People 2020. Lack of knowledge is described as a significant barrier to adherence to CRC screening. The aim of this study was to assess CRC knowledge and screening rates among Puerto Rican Hispanics. Participants aged 40-85 years were recruited from the internal medicine outpatient clinics at the University of Puerto Rico...
May 25, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28546165/strike-disrupts-research-at-puerto-rico-s-top-university
#2
Jeffrey Mervis
No abstract text is available yet for this article.
May 26, 2017: Science
https://www.readbyqxmd.com/read/28538734/zika-virus-evolution-and-spread-in-the-americas
#3
Hayden C Metsky, Christian B Matranga, Shirlee Wohl, Stephen F Schaffner, Catherine A Freije, Sarah M Winnicki, Kendra West, James Qu, Mary Lynn Baniecki, Adrianne Gladden-Young, Aaron E Lin, Christopher H Tomkins-Tinch, Simon H Ye, Daniel J Park, Cynthia Y Luo, Kayla G Barnes, Rickey R Shah, Bridget Chak, Giselle Barbosa-Lima, Edson Delatorre, Yasmine R Vieira, Lauren M Paul, Amanda L Tan, Carolyn M Barcellona, Mario C Porcelli, Chalmers Vasquez, Andrew C Cannons, Marshall R Cone, Kelly N Hogan, Edgar W Kopp, Joshua J Anzinger, Kimberly F Garcia, Leda A Parham, Rosa M Gélvez Ramírez, Maria C Miranda Montoya, Diana P Rojas, Catherine M Brown, Scott Hennigan, Brandon Sabina, Sarah Scotland, Karthik Gangavarapu, Nathan D Grubaugh, Glenn Oliveira, Refugio Robles-Sikisaka, Andrew Rambaut, Lee Gehrke, Sandra Smole, M Elizabeth Halloran, Luis Villar, Salim Mattar, Ivette Lorenzana, Jose Cerbino-Neto, Clarissa Valim, Wim Degrave, Patricia T Bozza, Andreas Gnirke, Kristian G Andersen, Sharon Isern, Scott F Michael, Fernando A Bozza, Thiago M L Souza, Irene Bosch, Nathan L Yozwiak, Bronwyn L MacInnis, Pardis C Sabeti
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28525923/a-national-implementation-project-to-prevent-catheter-associated-urinary-tract-infection-in-nursing-home-residents
#4
Lona Mody, M Todd Greene, Jennifer Meddings, Sarah L Krein, Sara E McNamara, Barbara W Trautner, David Ratz, Nimalie D Stone, Lillian Min, Steven J Schweon, Andrew J Rolle, Russell N Olmsted, Dale R Burwen, James Battles, Barbara Edson, Sanjay Saint
Importance: Catheter-associated urinary tract infection (UTI) in nursing home residents is a common cause of sepsis, hospital admission, and antimicrobial use leading to colonization with multidrug-resistant organisms. Objective: To develop, implement, and evaluate an intervention to reduce catheter-associated UTI. Design, Setting, and Participants: A large-scale prospective implementation project was conducted in community-based nursing homes participating in the Agency for Healthcare Research and Quality Safety Program for Long-Term Care...
May 19, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#5
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28523418/breast-cancer-and-exposure-to-tobacco-smoke-during-potential-windows-of-susceptibility
#6
Alexandra J White, Aimee A D'Aloisio, Hazel B Nichols, Lisa A DeRoo, Dale P Sandler
PURPOSE: An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. METHODS: Sister study participants (n = 50,884) aged 35-74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they were breast cancer-free but had a sister with breast cancer...
May 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28511884/the-impact-of-quality-variations-on-patients-undergoing-surgery-for-renal-cell-carcinoma-a-national-cancer-database-study
#7
Keith A Lawson, Olli Saarela, Robert Abouassaly, Simon P Kim, Rodney H Breau, Antonio Finelli
BACKGROUND: Despite efforts to define metrics assessing hospital-level quality for renal cell carcinoma (RCC) surgical care there remains a paucity of real-world data validating their ability to benchmark performance. Consequently, whether poor performance on hospital-level quality indicators is associated with inferior patient outcomes remains unknown. OBJECTIVES: To determine hospital-level variations in RCC surgical quality after adjusting for differences in patient- and tumor-specific factors...
May 13, 2017: European Urology
https://www.readbyqxmd.com/read/28511740/the-association-between-cognitive-decline-and-incident-depressive-symptoms-in-a-sample-of-older-puerto-rican-adults-with-diabetes
#8
Tyler Bell, Ana Luisa Dávila, Olivio Clay, Kyriakos S Markides, Ross Andel, Michael Crowe
BACKGROUND: Older Puerto Rican adults have particularly high risk of diabetes compared to the general US population. Diabetes is associated with both higher depressive symptoms and cognitive decline, but less is known about the longitudinal relationship between cognitive decline and incident depressive symptoms in those with diabetes. This study investigated the association between cognitive decline and incident depressive symptoms in older Puerto Rican adults with diabetes over a four-year period...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28511272/a-location-specific-spreadsheet-for-estimating-zika-risk-and-timing-for-zika-vector-surveillance-using-us-military-facilities-as-an-example
#9
Desmond H Foley, David B Pecor
Local Zika virus transmission in the United States involving one or both of the known vector species, Aedes aegypti and Ae. albopictus, is of major concern. To assist efforts to anticipate the risks of transmission, we developed an Excel spreadsheet tool that uses vector and virus temperature thresholds, remotely sensed maximum temperature, and habitat suitability models to answer the questions: "is Zika transmission likely here?" and "when should we conduct vector surveillance?" An example spreadsheet, updated regularly and freely available, uses near real-time and forecast temperature data to generate guidance, based on a novel four level Zika risk code, for 733 US military facilities in the 50 states, the District of Columbia, and the territories of Guam and Puerto Rico...
January 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28507984/immunoprevalence-to-six-waterborne-pathogens-in-beachgoers-at-boquer%C3%A3-n-beach-puerto-rico-application-of-a-microsphere-based-salivary-antibody-multiplex-immunoassay
#10
Swinburne A J Augustine, Kaneatra J Simmons, Tarsha N Eason, Clarissa L Curioso, Shannon M Griffin, Timothy J Wade, Alfred Dufour, G Shay Fout, Ann C Grimm, Kevin H Oshima, Elizabeth A Sams, Mary Jean See, Larry J Wymer
Waterborne infectious diseases are a major public health concern worldwide. Few methods have been established that are capable of measuring human exposure to multiple waterborne pathogens simultaneously using non-invasive samples such as saliva. Most current methods measure exposure to only one pathogen at a time, require large volumes of individual samples collected using invasive procedures, and are very labor intensive. In this article, we applied a multiplex bead-based immunoassay capable of measuring IgG antibody responses to six waterborne pathogens simultaneously in human saliva to estimate immunoprevalence in beachgoers at Boquerón Beach, Puerto Rico...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28500069/b-cell-activity-is-impaired-in-human-and-mouse-obesity-and-is-responsive-to-an-essential-fatty-acid-upon-murine-influenza-infection
#11
Rasagna Kosaraju, William Guesdon, Miranda J Crouch, Heather L Teague, E Madison Sullivan, Erik A Karlsson, Stacey Schultz-Cherry, Kymberly Gowdy, Lance C Bridges, Lauren R Reese, P Darrell Neufer, Michael Armstrong, Nichole Reisdorph, J Justin Milner, Melinda Beck, Saame Raza Shaikh
Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is limited information about the influence of obesity on B cell function and underlying factors that modulate B cell responses. Therefore, we studied B cell cytokine secretion and/or Ab production across obesity models. In obese humans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stimulation. In murine obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells...
May 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28499432/development-and-evaluation-of-a-community-based-buprenorphine-treatment-intervention
#12
Aaron D Fox, Nancy L Sohler, Taeko Frost, Carolina Lopez, Chinazo O Cunningham
BACKGROUND: The majority of Americans with opioid use disorder remain out of treatment. Operating in 33 states, Washington DC, and Puerto Rico, harm reduction agencies, which provide sterile syringes and other health services to people who inject drugs, are a key venue to reach out-of-treatment opioid users. Aiming to link out-of-treatment individuals with opioid use disorder to buprenorphine treatment, we developed a community-based buprenorphine treatment (CBBT) intervention in collaboration with New York City harm reduction agencies...
May 12, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28496556/epidemiological-profile-of-hispanics-admitted-with-acute-myocardial-infarction-in-puerto-rico-the-experience-of-2007-2009-and-2011
#13
Dagmar F Hernandez-Suarez, Anthony D Osterman-Pla, Onelys Carrasquillo, Juan Aranda, Stella Baez, Mariel Lopez, Enid J Garcia-Rivera
BACKGROUND: A limited number of studies have been published about coronary artery disease in Hispanics, particularly among the Puerto Rican population. The aim of this study was to present a clinical epidemiological profile and management practices in patients hospitalized in Puerto Rico with acute myocardial infarction (AMI). METHODS: This secondary data analysis from the Puerto Rico Cardiovascular Surveillance Study included 6,162 patients at 19 hospitals in Puerto Rico, during years 2007, 2009 and 2011...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28493944/a-decade-of-viral-mutations-and-associated-drug-resistance-in-a-population-of-hiv-1-puerto-ricans-2002-2011
#14
Lycely Del C Sepúlveda-Torres, Lavanya Rishishwar, Maria Luisa Rogers, Eddy Ríos-Olivares, Nawal Boukli, I King Jordan, Luis A Cubano
Puerto Rico has one of the highest rates of HIV/AIDS seen for any US state or territory, and antiretroviral therapy has been a mainstay of efforts to mitigate the HIV/AIDS public health burden on the island. We studied the evolutionary dynamics of HIV-1 mutation and antiretroviral drug resistance in Puerto Rico by monitoring the population frequency of resistance-associated mutations from 2002 to 2011. Whole blood samples from 4,475 patients were analyzed using the TRUGENE HIV-1 Genotyping Kit and OpenGene DNA Sequencing System in the Immunoretrovirus Research Laboratory at Universidad Central del Caribe...
2017: PloS One
https://www.readbyqxmd.com/read/28486582/binge-drinking-modifies-the-association-between-lifetime-alcohol-intake-and-breast-cancer-risk-in-moderate-drinkers
#15
Alexandra J White, Lisa A DeRoo, Clarice R Weinberg, Dale P Sandler
The prevalence of binge drinking is rising in the United States. While alcohol is a breast cancer risk factor, less is known about the impact of episodic heavy drinking. Breast cancer-free women, ages 35-74, were enrolled in the Sister Study from 2003-2009 (n = 50,884). United States or Puerto Rico residents who had a sister with breast cancer were eligible. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer. 1,843 invasive breast cancers were diagnosed during follow-up (mean = 6...
May 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28484439/amino-acid-residues-68-71-contribute-to-influenza-a-virus-pb1-f2-protein-stability-and-functions
#16
Yi-Ying Cheng, Shih-Rang Yang, Ying-Ting Wang, Yu-Hsin Lin, Chi-Ju Chen
Influenza A virus PB1-F2, encoding a multi-functional protein, is regarded as a virulent gene. Variation in expression pattern and protein stability among PB1-F2 proteins derived from different strains may explain why PB1-F2 functions in a strain- and cell type-specific manner. Because the protein stability of PB1-F2 affects its biological functions, we looked for sequences important for this property. By comparing variants and chimeric of PB1-F2 proteins from A/Hong Kong/156/1997 (H5N1) and A/Puerto Rico/8/1934 (H1N1), we identified amino acid residues 68-71 affect its protein stability...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28483582/the-role-of-heterotypic-denv-specific-cd8-t-lymphocytes-in-an-immunocompetent-mouse-model-of-secondary-dengue-virus-infection
#17
Laura B Talarico, Juan P Batalle, Alana B Byrne, Jorge M Brahamian, Adrián Ferretti, Ayelén G García, Aldana Mauri, Carla Simonetto, Diego R Hijano, Andrea Lawrence, Patricio L Acosta, Mauricio T Caballero, Yésica Paredes Rojas, Lorena I Ibañez, Guillermina A Melendi, Félix A Rey, Elsa B Damonte, Eva Harris, Fernando P Polack
Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations. Here, we present an immunocompetent mouse model of secondary DENV infection using non mouse-adapted DENV strains to investigate the pathogenesis of severe dengue disease. C57BL/6 mice infected sequentially with DENV-1 (strain Puerto Rico/94) and DENV-2 (strain Tonga/74) developed low platelet counts, internal hemorrhages, and increase of liver enzymes...
April 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28481690/two-year-antibody-persistence-in-children-vaccinated-at-12-15%C3%A2-months-with-a-measles-mumps-rubella-virus-vaccine-without-human-serum-albumin
#18
Andrea A Berry, Remon Abu-Elyazeed, Clemente Diaz-Perez, Maurice A Mufson, Christopher J Harrison, Michael Leonardi, Jerry D Twiggs, Christopher Peltier, Stanley Grogg, Antonio Carbayo, Steven Shapiro, Michael Povey, Carmen Baccarini, Bruce L Innis, Ouzama Henry
One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12-15 months of age in the primary study (NCT00861744), were followed-up for two years post-vaccination. Anti-measles and anti-rubella antibodies were measured using Enzyme-Linked Immunosorbent Assay (ELISA), and anti-mumps antibodies using ELISA and plaque reduction neutralization (PRN) assays...
May 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28480145/insights-of-the-dental-calculi-microbiome-of-pre-columbian-inhabitants-from-puerto-rico
#19
Tasha M Santiago-Rodriguez, Yvonne Narganes-Storde, Luis Chanlatte-Baik, Gary A Toranzos, Raul J Cano
BACKGROUND: The study of ancient microorganisms in mineralized dental plaque or calculi is providing insights into microbial evolution, as well as lifestyles and disease states of extinct cultures; yet, little is still known about the oral microbial community structure and function of pre-Columbian Caribbean cultures. In the present study, we investigated the dental calculi microbiome and predicted function of one of these cultures, known as the Saladoid. The Saladoids were horticulturalists that emphasized root-crop production...
2017: PeerJ
https://www.readbyqxmd.com/read/28472419/the-distribution-of-cicadellinae-leafhoppers-and-other-auchenorrhyncha-on-coffee-and-citrus-in-puerto-rico
#20
Brent V Brodbeck, Peter C Andersen, Steve Oden, Russell F Mizell, Stuart H McKamey, Mildred Zapata
: Caribovia coffeacola, Cicadellinae, coffee, Xylella fastidiosa.
June 1, 2017: Environmental Entomology
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