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https://www.readbyqxmd.com/read/29134099/assessment-of-owner-directed-aggressive-behavioural-tendencies-of-dogs-in-situations-of-possession-and-manipulation
#1
Anna Bálint, Gabriella Rieger, Ádám Miklósi, Péter Pongrácz
Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: 'take away bone' and 'roll over'. Based on dogs' behaviour in the tests, we sorted dogs (N = 93) in two groups for each test, namely a less and a more disobedient/resistant group...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29131675/dedifferentiated-chondrosarcoma-in-the-dog-and-cat-a-case-series-and-review-of-the-literature
#2
Arathi Vinayak, Deanna R Worley, Stephen J Withrow, Dustin S Adams, Barbara E Powers
This retrospective case series describes seven dogs and one cat diagnosed with dedifferentiated chondrosarcoma, an uncommon, aggressive variant of chondrosarcoma. The purpose of the study is to describe clinical, imaging, and histopathological findings of this tumor. Medical records and the diagnostic laboratory database at Colorado State University from 2000 to 2015 were reviewed and complete medical records were available for the eight animals in this report. Similar to what has been reported in people, poor long-term survival and high metastatic rate, particularly to the lungs, was observed in our case series...
November 13, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29100308/integration-of-genomic-transcriptomic-and-functional-profiles-of-aggressive-osteosarcomas-across-multiple-species
#3
Lara E Davis, Sophia Jeng, Matthew N Svalina, Elaine Huang, Janét Pittsenbarger, Emma L Cantor, Noah Berlow, Bernard Seguin, Atiya Mansoor, Shannon K McWeeney, Charles Keller
In complex, highly unstable genomes such as in osteosarcoma, targeting aberrant checkpoint processes (metabolic, cell cycle or immune) may prove more successful than targeting specific kinase or growth factor signaling pathways. Here, we establish a comparative oncology approach characterizing the most lethal osteosarcomas identified in a biorepository of tumors from three different species: human, mouse and canine. We describe the development of a genetically-engineered mouse model of osteosarcoma, establishment of primary cell cultures from fatal human tumors, and a biorepository of osteosarcoma surgical specimens from pet dogs...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29090969/expression-of-cat-podoplanin-in-feline-squamous-cell-carcinomas
#4
Shunsuke Itai, Shinji Yamada, Mika K Kaneko, Hiroyuki Harada, Yumiko Kagawa, Satoru Konnai, Yukinari Kato
Oral squamous cell carcinoma is an aggressive tumor in cats; however, molecular-targeted therapies against this tumor, including antibody therapy, have not been developed. Sensitive and specific monoclonal antibodies (mAbs) against highly expressed membrane proteins are needed to develop antibody therapies. Podoplanin, a type I transmembrane glycoprotein, is expressed in many human malignant tumors, including brain tumor, esophageal cancer, lung cancer, mesothelioma, and oral cancer. Podoplanin binds to C-type lectin-like receptor-2 (CLEC-2) and activates platelet aggregation, which is involved in cancer metastasis...
November 1, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29067211/pilot-assessment-of-vascular-endothelial-growth-factor-receptors-and-trafficking-pathways-in-recurrent-and-metastatic-canine-subcutaneous-mast-cell-tumours
#5
Lucas Da Silva, Carlos E Fonseca-Alves, Jennifer J Thompson, Robert A Foster, Geoffrey A Wood, Renee L Amorim, Brenda L Coomber
Canine subcutaneous mast cell tumour (scMCT) shows less aggressive biological behaviour than cutaneous MCT. Vascular endothelial growth factor receptor 2 (VEGFR2) is expressed by neoplastic cells in canine scMCT, but the relevance of this signalling pathway for disease pathobiology is not clear. The objective of this study was to quantify VEGF-A, VEGFR2, pVEGFR2, the VEGF co-receptor Neuropilin 1 (NRP-1) and the E3 ubiquitin protein ligase c-Cbl in canine scMCT, and to evaluate their association with disease outcome...
August 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29063312/canine-invasive-mammary-carcinomas-as-models-of-human-breast-cancer-part-2-immunophenotypes-and-prognostic-significance
#6
Jérôme Abadie, Frédérique Nguyen, Delphine Loussouarn, Laura Peña, Adelina Gama, Natascha Rieder, Anton Belousov, Ingrid Bemelmans, Laëtitia Jaillardon, Catherine Ibisch, Mario Campone
PURPOSE: Relevant animal models of human breast cancer are currently needed, especially for the aggressive triple-negative breast cancer subtype. Recent studies and our results (Part 1) indicate that spontaneous canine invasive mammary carcinomas (CMCs) resemble human breast cancer by clinics and pathology as well as behavior and prognostic indicators. We hypothesized that the current molecular classifications of human breast cancer, used for therapeutic decision, could be relevant to dogs...
October 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29061119/computer-controlled-closed-loop-drug-infusion-system-for-automated-hemodynamic-resuscitation-in-endotoxin-induced-shock
#7
Kazunori Uemura, Toru Kawada, Can Zheng, Meihua Li, Masaru Sugimachi
BACKGROUND: Hemodynamic resuscitation in septic shock requires aggressive fluid replacement and appropriate use of vasopressors to optimize arterial pressure (AP) and cardiac output (CO). Because responses to these drugs vary between patients and within patient over time, strict monitoring of patient condition and repetitive adjustment of drug dose are required. This task is time and labor consuming, and is associated with poor adherence to resuscitation guidelines. To overcome this issue, we developed a computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock, and evaluated the performance of the system in a canine model of endotoxin shock...
October 23, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29038862/examining-spatial-patterns-of-selection-and-use-for-an-altered-predator-guild
#8
Matthew A Mumma, Joseph D Holbrook, Nathaniel D Rayl, Christopher J Zieminski, Todd K Fuller, John F Organ, Shane P Mahoney, Lisette P Waits
Anthropogenic disturbances have altered species' distributions potentially impacting interspecific interactions. Interference competition is when one species denies a competing species access to a resource. One mechanism of interference competition is aggression, which can result in altered space-use of a subordinate species due to the threat of harm, otherwise known as a 'landscape of fear'. Alternatively, subordinates might outcompete dominant species in resource-poor environments via a superior ability to extract resources...
December 2017: Oecologia
https://www.readbyqxmd.com/read/29035774/facial-dog-bite-injuries-in-children-a-case-report
#9
Alessandro Leite Cavalcanti, Edgleys Porto, Bruno Ferreira Dos Santos, Christiane Leite Cavalcanti, Alidianne Fábia Cabral Cavalcanti
INTRODUCTION: Dog bites are common and can affect victims of different ages, from children to the elderly. Injuries are usually located in different body regions, including head and face. The treatment of choice for injuries is the suture of the lesion, accompanied by antibiotic therapy and tetanus and anti-rabies vaccination. PRESENTATION OF CASE: An 11-year-old male black patient was admitted to the Surgery and Maxillo-Facial Traumatology Service, on an urgent basis, victim of domestic animal aggression (dog biting)...
October 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29027053/public-health-considerations-associated-with-the-location-and-operation-of-off-leash-dog-parks
#10
REVIEW
Tissa Rahim, Pablo Romero Barrios, Geoffrey McKee, Melissa McLaws, Tom Kosatsky
Off-leash dog parks may enhance human health, but may also lead to health risk through infection or canine aggression. Published evidence was reviewed to examine positive and negative public health impacts of off-leash dog parks, as well as strategies for enhancing benefits and mitigating risks. Evidence suggests that off-leash dog parks can benefit physical and social health, as well as community connectedness. While studies have documented shedding of zoonotic agents in dog parks, the risk of transmission to humans is relatively unknown...
October 12, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/29021768/endogenous-oxytocin-vasopressin-and-aggression-in-domestic-dogs
#11
Evan L MacLean, Laurence R Gesquiere, Margaret E Gruen, Barbara L Sherman, W Lance Martin, C Sue Carter
Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)-neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species-and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28963729/long-term-treatment-with-methylene-blue-in-a-dog-with-hereditary-methemoglobinemia-caused-by-cytochrome-b5-reductase-deficiency
#12
J A Jaffey, M R Harmon, N A Villani, E K Creighton, G S Johnson, U Giger, J R Dodam
A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co-oximetry identified an increased methemoglobin concentration (27%; normal, <2%) with normal arterial oxygen tension. The methemoglobinemia and associated clinical signs resolved after administration of methylene blue (1 mg/kg) IV, and the dog was discharged...
September 29, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28960447/jak1-2-inhibitors-azd1480-and-cyt387-inhibit-canine-b-cell-lymphoma-growth-by-increasing-apoptosis-and-disrupting-cell-proliferation
#13
Z Lu, C C Hong, P C Jark, A L F V Assumpção, N Bollig, G Kong, X Pan
BACKGROUND: Canine diffuse large B-cell lymphoma (DLBCL) is a common and aggressive hematologic malignancy. The lack of conventional therapies with sustainable efficacy warrants further investigation of novel therapeutics. The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways play important roles in the pathogenesis of hematologic malignancies in humans including DLBCLs. AZD1480 and CYT387 are novel JAK1/2 inhibitors that have been used in clinical trials for treating various hematologic cancers in humans...
September 27, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28944041/understanding-the-context-for-pet-cat-and-dog-feeding-and-exercising-behaviour-among-pet-owners-in-ireland-a-qualitative-study
#14
Martin J Downes, Catherine Devitt, Marie T Downes, Simon J More
BACKGROUND: Pet cat and dog obesity contributes to increased risk of several diseases, including cancer and diabetes mellitus as well as a worsening of orthopaedic problems, and a reduction in survival rate. This study aims to develop a better understanding of cat and dog owners' self-reported beliefs and factors that influence owner behaviour around feeding and exercising their pet cat or dog, as there is a lack of in-depth understanding in this area. Seven focus group discussions, with 43 pet owners in total, were conducted...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28933959/what-makes-a-dog-adoptable-an-eye-tracking-investigation
#15
Sara Isgate, Justin J Couchman
Humans readily attribute personality and behavioral traits to dogs, and these attributions influence decisions about adoption. This study focused on how these attributions could be influenced by breed and pose by using pictures of four breeds (Doberman Pinscher, Golden Retriever, pit bull, and Rottweiler) in 4 poses (dog sitting alone, sitting with a human, standing alone, and walking on a leash with a human). Participants rated each picture on friendliness, aggressiveness, and adoptability. Eye-tracking technology identified which specific features were represented in each picture to determine whether they had any effect on the judgments...
January 2018: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28929581/gain-of-function-mutation-in-ptpn11-in-histiocytic-sarcomas-of-bernese-mountain-dogs
#16
T Thaiwong, S Sirivisoot, M Takada, V Yuzbasiyan-Gurkan, M Kiupel
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm of dendritic cell origin that is common in certain breeds of dogs. High prevalence of fatal, disseminated HS has been described in Bernese Mountain Dogs (BMDs). Support for genetic predisposition to develop HS has been presented in several studies, but to date, causative genetic events have not been reported. In addition, no driver mutations have been identified in tumours. Recently, E76K gain-of-function mutation in SHP2 encoded by the PTPN11 gene has been described in human histiocytic malignancies...
September 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28913904/re-emergence-of-rabies-virus-maintained-by-canid-populations-in-paraguay
#17
A C F Amarilla, J C A Pompei, D B Araujo, F A Vázquez, R R Galeano, L M Delgado, G Bogado, M Colman, L Sanabria, K Iamamoto, R Garcia, D Assis, R Recalde, L F Martorelli, E Quiñones, A Cabello, M Martini, O Cosivi, E L Durigon, S R Favoretto
Paraguay has registered no human cases of rabies since 2004, and the last case in dogs, reported in 2009, was due to a variant maintained in the common vampire bat "Desmodus rotundus". In 2014, a dog was diagnosed as positive for rabies with aggression towards a boy and all required measures of control were successfully adopted. Epidemiological investigation revealed that the dog was not vaccinated and had been attacked by a crab-eating fox, "zorro" (Cerdocyon thous). The sample was diagnosed by the Official Veterinary Service of the Country and sent to the Center on Rabies Research from the University of São Paulo, Brazil, for antigenic and genetic characterization...
September 14, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28910468/estimation-of-dog-bite-risk-and-related-morbidity-among-personnel-working-with-military-dogs
#18
H Schermann, N Eiges, A Sabag, E Kazum, A Albagli, M Salai, A Shlaifer
BACKGROUND: Soldiers serving in the Israel Defense Force Military Working Dogs (MWD) Unit spend many hours taming dogs' special skills, taking them on combat missions, and performing various dogkeeping activities. During this intensive work with the aggressive military dogs, bites are common, and some of them result in permanent disability. However, this phenomenon has not been quantified or reported as an occupational hazard. METHODS: This was a retrospective cohort study based on self-administered questionnaires...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28877511/severe-neurotoxicity-requiring-mechanical-ventilation-in-a-dog-envenomed-by-a-red-bellied-black-snake-pseudechis-porphyriacus-and-successful-treatment-with-an-experimental-bivalent-whole-equine-igg-antivenom
#19
A M Padula, E M Leister
Snakebite in dogs from Pseudechis porphyriacus (red-bellied black snake; RBBS) is a common envenomation treated by veterinarians in Australia where this snake occurs. This case report describes the successful treatment of a clinically severe RBBS envenomation in a dog with an experimental bivalent equine whole IgG antivenom and mechanical ventilation, following its presentation in a cyanotic state. The cause of the cyanosis and respiratory distress was considered due to paralysis from neurotoxins in RBBS venom...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28875568/gene-expression-of-matrix-metalloproteinases-and-their-inhibitors-timps-in-meningiomas-of-dogs
#20
M T Mandara, A Reginato, G Foiani, S De Luca, G Guelfi
BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are considered to be key mediators of tumor invasion and metastasis. MMP-2 and MMP-9 are expressed in meningiomas of dogs, but TIMP expression, and variations of specific MMP/TIMP ratios still are unknown in this tumor. HYPOTHESIS/OBJECTIVES: Expression of MMP/TIMP might increase progressively from grade I to grade III meningioma. Therefore, genetic expression of MMP-2 and MMP-9, and specific TIMP-2 and TIMP-1, respectively, has been investigated in meningiomas of different grades...
September 5, 2017: Journal of Veterinary Internal Medicine
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