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Advanced glycation endproducts

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https://www.readbyqxmd.com/read/28712835/biological-impact-of-advanced-glycation-endproducts-on-estrogen-receptor-positive-mcf-7-breast-cancer-cells
#1
Sabine Matou-Nasri, Hana Sharaf, Qiuyu Wang, Nasser Almobadel, Zaki Rabhan, Hamad Al-Eidi, Wesam Bin Yahya, Thadeo Trivilegio, Rizwan Ali, Nasser Al-Shanti, Nessar Ahmed
Diabetes mellitus potentiates the risk of breast cancer. We have previously described the pro-tumorigenic effects of advanced glycation endproducts (AGEs) on estrogen receptor (ER)-negative MDA-MB-231 breast cancer cell line mediated through the receptor for AGEs (RAGE). However, a predominant association between women with ER-positive breast cancer and type 2 diabetes mellitus has been reported. Therefore, we have investigated the biological impacts of AGEs on ER-positive human breast cancer cell line MCF-7 using in vitro cell-based assays including cell count, migration, and invasion assays...
July 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28679295/advanced-glycation-endproducts-ages-in-saliva-of-patients-with-multiple-myeloma-a-pilot-study
#2
Joseph Katz, Jan Moreb, Catherine Baitinger, Christine Singer, Robert M Caudle
Multiple myeloma (MM) is a hematological cancer with underlying causes associated with increased oxidative stress. Through signaling of their receptor RAGE, advanced glycation endproducts (AGEs) are known to increase oxidative stress associated with malignant transformation. In the present study, we have demonstrated that the levels of these compounds are increased in the saliva of myeloma patients with bone lesions. This data may provide a potential marker for bone lesions in MM and a potential target for the treatment of myeloma by blocking the AGEs or their receptor...
July 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28678851/receptor-for-advanced-glycation-endproducts-rage-maintains-pulmonary-structure-and-regulates-the-response-to-cigarette-smoke
#3
Lisa Wolf, Christian Herr, Julia Niederstraßer, Christoph Beisswenger, Robert Bals
The receptor for advanced glycation endproducts (RAGE) is highly expressed in the lung but its physiological functions in this organ is still not completely understood. To determine the contribution of RAGE to physiological functions of the lung, we analyzed pulmonary mechanics and structure of wildtype and RAGE deficient (RAGE-/-) mice. RAGE deficiency spontaneously resulted in a loss of lung structure shown by an increased mean chord length, increased respiratory system compliance, decreased respiratory system elastance and increased concentrations of serum protein albumin in bronchoalveolar lavage fluids...
2017: PloS One
https://www.readbyqxmd.com/read/28660310/advanced-glycation-endproducts-induce-self-and-cross-tolerance-in-monocytes
#4
Florian Uhle, Sebastian Weiterer, Benedikt Hermann Siegler, Thorsten Brenner, Christoph Lichtenstern, Markus Alexander Weigand
INTRODUCTION: Advanced glycation endproducts (AGEs) are well-known inflammatory mediators, which are recognized by immune cells through their corresponding receptor RAGE and have been shown to participate in the pathophysiology of a variety of acute as well as chronic inflammatory diseases. Nevertheless, no data are available on the aftermath of AGE recognition on immune cells. MATERIALS AND METHODS: We used the monocytic cell line MonoMac6 as well as primary human monocytes for double stimulation experiments...
June 28, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28656390/association-between-habitual-dietary-and-lifestyle-behaviours-and-skin-autofluorescence-saf-a-marker-of-tissue-accumulation-of-advanced-glycation-endproducts-ages-in-healthy-adults
#5
Nicole J Kellow, Melinda T Coughlan, Christopher M Reid
PURPOSE: Advanced glycation endproducts (AGEs) are produced endogenously and also enter the body during the consumption of AGEs present in heat-processed food. It is unknown whether AGEs of dietary origin accumulate within the body of healthy individuals. AGEs can deposit within skin tissue long-term by crosslinking extracellular matrix proteins. The fluorescent nature of many AGEs enables their detection within the skin by non-invasively measuring skin autofluorescence (SAF). This study aimed to identify habitual dietary and lifestyle behaviours cross-sectionally associated with SAF in an adult population sample...
June 27, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28653535/digestibility-of-glyoxal-glycated-%C3%AE-casein-and-%C3%AE-lactoglobulin-and-distribution-of-peptide-bound-advanced-glycation-end-products-in-gastrointestinal-digests
#6
Di Zhao, Lin Li, Thao T Le, Lotte Bach Larsen, Guoying Su, Yi Liang, Bing Li
This work reports the influence of glyoxal (GO)-derived glycation on the gastrointestinal enzymatic hydrolysis of β-lactoglobulin and β-casein. Reduced digestibility of glycated proteins was found in both gastric and intestinal stage. Distribution of Maillard reaction products in digests with different molecular weight ranges was investigated subsequently. The colorless and brown MRPs largely presented in the digests smaller than 20 kDa. However, the resistance of fluorescent advanced glycation end products (AGEs) to enzymatic hydrolysis gradually increased during glycation, rendering fluorescent AGEs largely present in the digests larger than 20 kDa...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28630614/a-plant-based-diet-for-the-prevention-and-treatment-of-type-2-diabetes
#7
REVIEW
Michelle McMacken, Sapana Shah
The prevalence of type 2 diabetes is rising worldwide, especially in older adults. Diet and lifestyle, particularly plant-based diets, are effective tools for type 2 diabetes prevention and management. Plant-based diets are eating patterns that emphasize legumes, whole grains, vegetables, fruits, nuts, and seeds and discourage most or all animal products. Cohort studies strongly support the role of plant-based diets, and food and nutrient components of plant-based diets, in reducing the risk of type 2 diabetes...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28629450/interaction-with-adipocyte-stromal-cells-induces-breast-cancer-malignancy-via-s100a7-upregulation-in-breast-cancer-microenvironment
#8
Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Takanori Ishida, Noriaki Ohuchi, Hironobu Sasano
BACKGROUND: Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma-adipose stromal cell (ASC) interactions have been considered pivotal in supporting tumor growth in breast cancer. In addition, it has been demonstrated that the biological features of cancer-associated adipocytes differ from those of normal ASCs. Therefore, we investigated an interaction between ASCs and carcinoma cell lines to identify genes associated with ASC invasion of carcinoma cells...
June 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28624351/inhibitory-effect-of-vitamin-b3-against-glycation-and-reactive-oxygen-species-production-in-hsa-an-in%C3%A2-vitro-approach
#9
K M Abdullah, Faizan Abul Qais, Iqbal Ahmad, Imrana Naseem
Hyperglycaemia is a key factor for the formation of advanced glycated endproducts (AGEs). Inhibition of glycation may play key role in minimizing the diabetes related complications. We have tried to explore the glucose and methyl glyoxal mediated glycation and antiglycation activity of niacin using human serum albumin as model protein. Protein was incubated with glucose for 28 days at physiological temperature to achieve glycation. Antiglycation activity was evaluated by assessing free lysine, carbonyl content, AGE specific fluorescence...
June 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28610627/multiple-biomarkers-predict-disease-severity-progression-and-mortality-in-copd
#10
Rachel L Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E Miller, Ruth Tal-Singer, Russell P Bowler
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severity, and disease progression. Just as combined clinical variables are more highly predictive of outcomes than individual clinical variables, we hypothesized that multiple biomarkers may be more informative than individual biomarkers to predict subtypes, disease severity, disease progression, and mortality...
June 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28595946/the-effects-of-pessimism-on-cell-mediated-immunity-in-rats
#11
Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka, Michael Maes, Rafal Rygula
We used a recently developed ambiguous-cue interpretation (ACI) paradigm to investigate whether 'optimism' and 'pessimism' as behavioural traits may be interrelated with immune functions in rodents. To this aim, in a series of ACI tests (cognitive bias screening, CBS), we identified rats that displayed 'pessimistic' and 'optimistic' traits. We found significant differences in immune biomarkers between 'optimistic' and 'pessimistic' animals. Moreover 'pessimism' was associated with significantly lower relative weight of the spleen and thymus, significantly decreased proliferative activity of splenocytes...
June 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28588100/higher-plasma-methylglyoxal-levels-are-associated-with-incident-cardiovascular-disease-in-individuals-with-type-1-diabetes-a-12-year-follow-up-study
#12
Nordin M J Hanssen, Jean L J M Scheijen, Anders Jorsal, Hans-Henrik Parving, Lise Tarnow, Peter Rossing, Coen D A Stehouwer, Casper G Schalkwijk
Methylglyoxal (MGO), a major precursor for advanced glycation endproducts (AGEs), is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma MGO levels are associated with incident CVD in people with type 1 diabetes is unknown. We included 159 individuals with persistent normoalbuminuria and 162 individuals with diabetic nephropathy (DN) from the outpatient clinic at Steno Diabetes Center. We measured MGO at baseline. We recorded fatal and non-fatal CVD over a median follow-up of 12...
June 6, 2017: Diabetes
https://www.readbyqxmd.com/read/28579250/dna-methylation-of-extracellular-matrix-remodeling-genes-in-children-exposed-to-arsenic
#13
Tania Gonzalez-Cortes, Rogelio Recio-Vega, Robert Clark Lantz, Binh T Chau
Several novel mechanistic findings regarding to arsenic's pathogenesis has been reported and some of them suggest that the etiology of some arsenic induced diseases are due in part to heritable changes to the genome via epigenetic processes such as DNA methylation, histone maintenance, and mRNA expression. Recently, we reported that arsenic exposure during in utero and early life was associated with impairment in the lung function and abnormal receptor for advanced glycation endproducts (RAGE), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) sputum levels...
June 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28542559/fluvastatin-inhibits-age-induced-cell-proliferation-and-migration-via-an-erk5-dependent-nrf2-pathway-in-vascular-smooth-muscle-cells
#14
Ae-Rang Hwang, Jung-Hwa Han, Jae Hyang Lim, Young Jin Kang, Chang-Hoon Woo
Advanced glycation endproduct (AGE)-induced vascular smooth muscle cell (VSMC) proliferation and reactive oxygen species (ROS) production are emerging as important mechanisms of diabetic vasculopathy, but little is known about the molecular mechanism responsible for the antioxidative effects of statins on AGEs. It has been reported that statins exert pleiotropic effects on the cardiovascular system due to decreases in AGE-induced cell proliferation, migration, and vascular inflammation. Thus, in the present study, the authors investigated the molecular mechanism by which statins decrease AGE-induced cell proliferation and VSMC migration...
2017: PloS One
https://www.readbyqxmd.com/read/28539495/correction-to-2016-atvb-plenary-lecture-receptor-for-advanced-glycation-endproducts-and-implications-for-the-pathogenesis-and-treatment-of-cardiometabolic-disorders-spotlight-on-the-macrophage
#15
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28535048/control-of-maillard-reactions-in-foods-strategies-and-chemical-mechanisms
#16
REVIEW
Marianne N Lund, Colin A Ray
Maillard reactions lead to changes in food color, organoleptic properties, protein functionality, and protein digestibility. Numerous different strategies for controlling Maillard reactions in foods have been attempted during the past decades. In this paper, recent advances in strategies for controlling the Maillard reaction and subsequent downstream reaction products in food systems are critically reviewed. The underlying mechanisms at play are presented, strengths and weaknesses of each strategy are discussed, and reasonable reaction mechanisms are proposed to reinforce the evaluations...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28527897/advanced-glycation-endproducts-form-during-ovalbumin-digestion-in-the-presence-of-fructose-inhibition-by-chlorogenic-acid
#17
Yasmin Bains, Alejandro Gugliucci, Russell Caccavello
BACKGROUND: One mechanism by which fructose could exert deleterious effects is through intestinal formation and absorption of pro-inflammatory advanced glycation endproducts via the Maillard reaction. We employed simulated stomach and duodenum digestion of ovalbumin (OVA) to test the hypothesis that advanced glycation endproducts (AGEs) are formed by fructose during simulated digestion of a ubiquitous food protein under model physiological conditions. METHODS: OVA was subjected to simulated gastric and intestinal digestion using standard models, in presence of fructose or glucose (0-100mM)...
May 17, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28512639/inhibitory-effect-of-chemical-constituents-isolated-from-artemisia-iwayomogi-on-polyol-pathway-and-simultaneous-quantification-of-major-bioactive-compounds
#18
Yoon Kyoung Lee, Eun Young Hong, Wan Kyunn Whang
Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. Artemisia iwayomogi has long been used as treatment of various diseases in Korea. However, no literatures have reported on AR and AGEs formation inhibitory activities of A. iwayomogi. For these reasons, we aimed to assess that A. iwayomogi had potential as anti-diabetic complications agents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28507520/in-vitro-and-in-silico-antidiabetic-and-antimicrobial-evaluation-of-constituents-from-kickxia-ramosissima-nanorrhinum-ramosissimum
#19
Adnan Amin, Emmy Tuenter, Kenn Foubert, Jamhsed Iqbal, Paul Cos, Louis Maes, Vassiliki Exarchou, Sandra Apers, Luc Pieters
Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isolated and evaluated in vitro in assays related to the traditional use. Methods: Dried whole plant material was extracted and chromatographically fractionated. Isolated constituents were evaluated in silico and in vitro in assays related to the traditional use against diabetes (inhibition of α-glucosidase activity; inhibition of advanced glycation endproducts) and in inflammatory conditions (inhibition of AAPH induced linoleic acid peroxidation, inhibition of 15-LOX, antimicrobial activity)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28495931/neutrophil-extracellular-traps-drive-endothelial-to-mesenchymal-transition
#20
Elmar Pieterse, Nils Rother, Marjolein Garsen, Julia M Hofstra, Simon C Satchell, Markus Hoffmann, Markus A Loeven, Hanneke K Knaapen, Olivier W H van der Heijden, Jo H M Berden, Luuk B Hilbrands, Johan van der Vlag
OBJECTIVE: An excessive release and impaired degradation of neutrophil extracellular traps (NETs) leads to the continuous exposure of NETs to the endothelium in a variety of hematologic and autoimmune disorders, including lupus nephritis. This study aims to unravel the mechanisms through which NETs jeopardize vascular integrity. APPROACH AND RESULTS: Microvascular and macrovascular endothelial cells were exposed to NETs, and subsequent effects on endothelial integrity and function were determined in vitro and in vivo...
July 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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