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Advanced glycation endproducts

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https://www.readbyqxmd.com/read/27913191/the-shedding-derived-soluble-receptor-for-advanced-glycation-endproducts-sustains-inflammation-during-acute-pseudomonas-aeruginosa-lung-infection
#1
Antonella Antonelli, Stefania Di Maggio, Joanna Rejman, Francesca Sanvito, Alice Rossi, Alessandro Catucci, Andrea Gorzanelli, Alessandra Bragonzi, Marco E Bianchi, Angela Raucci
BACKGROUND: The membrane-bound isoform of the receptor for advanced glycation end products (FL-RAGE) is primarily expressed by alveolar epithelial cells and undergoes shedding by the protease ADAM10, giving rise to soluble cleaved RAGE (cRAGE). RAGE has been associated with the pathogenesis of several acute and chronic lung disorders. Whether the proteolysis of FL-RAGE is altered by a given inflammatory stimulus is unknown. Pseudomonas aeruginosa causes nosocomial infections in hospitalized patients and is the major pathogen associated with chronic lung diseases...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27870582/markers-of-islet-endothelial-dysfunction-occur-in-male-db-db-mice-and-may-contribute-to-reduced-insulin-release
#2
Meghan F Hogan, Amy W Liu, Michael J Peters, Joshua R Willard, Zaheen Rabbani, Erik C Bartholomew, Adam Ottley, Rebecca L Hull
Islet endothelial cells produce paracrine factors that support β-cell function and growth. Endothelial dysfunction underlies diabetic microvascular complications; thus we hypothesized that in diabetes, islet endothelial cells become dysfunctional and this may contribute to β-cell secretory dysfunction. Islets/islet endothelial cells were isolated from diabetic db/db mice, treated with or without the glucose-lowering agent phlorizin, or C57BL/6J mice fed a high fat diet for 18 weeks (and appropriate controls)...
November 21, 2016: Endocrinology
https://www.readbyqxmd.com/read/27858716/skin-autofluorescence-examination-as%C3%A2-a%C3%A2-diagnostic-tool-for-mild-cognitive-impairment-in-healthy-people
#3
Michiya Igase, Maya Ohara, Keiji Igase, Takeaki Kato, Yoko Okada, Masayuki Ochi, Yasuharu Tabara, Katsuhiko Kohara, Yasumasa Ohyagi
BACKGROUND: Accumulation of advanced glycation endproducts (AGEs) is thought to be involved in the pathogenesis of dementia, especially Alzheimer's disease. Tissue AGE accumulation can be estimated using the relative simple noninvasive measurement of skin autofluorescence (SAF), a method based on the fluorescent properties of some AGEs. However, possible involvement of tissue AGE accumulation in mild cognitive impairment (MCI) has not been fully investigated. OBJECTIVE: We investigated whether tissue AGE accumulation estimated by SAF is associated with mild cognitive impairment...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27858225/putative-model-for-heat-shock-protein-70-complexation-with-receptor-of-advanced-glycation-end-products-through-fluorescence-proximity-assays-and-normal-mode-analyses
#4
Marcelo Sartori Grunwald, Rodrigo Ligabue-Braun, Cristiane Santos Souza, Luana Heimfarth, Hugo Verli, Daniel Pens Gelain, José Cláudio Fonseca Moreira
Extracellular heat shock protein 70 (HSP70) is recognized by receptors on the plasma membrane, such as Toll-like receptor 4 (TLR4), TLR2, CD14, and CD40. This leads to activation of nuclear factor-kappa B (NF-κB), release of pro-inflammatory cytokines, enhancement of the phagocytic activity of innate immune cells, and stimulation of antigen-specific responses. However, the specific characteristics of HSP70 binding are still unknown, and all HSP70 receptors have not yet been described. Putative models for HSP70 complexation to the receptor for advanced glycation endproducts (RAGEs), considering both ADP- and ATP-bound states of HSP70, were obtained through molecular docking and interaction energy calculations...
November 17, 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27809834/in-vitro-inhibitory-activities-of-selected-australian-medicinal-plant-extracts-against-protein-glycation-angiotensin-converting-enzyme-ace-and-digestive-enzymes-linked-to-type-ii-diabetes
#5
Permal Deo, Erandi Hewawasam, Aris Karakoulakis, David J Claudie, Robert Nelson, Bradley S Simpson, Nicholas M Smith, Susan J Semple
BACKGROUND: There is a need to develop potential new therapies for the management of diabetes and hypertension. Australian medicinal plants collected from the Kuuku I'yu (Northern Kaanju) homelands, Cape York Peninsula, Queensland, Australia were investigated to determine their therapeutic potential. Extracts were tested for inhibition of protein glycation and key enzymes relevant to the management of hyperglycaemia and hypertension. The inhibitory activities were further correlated with the antioxidant activities...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27805071/ages-induced-autophagy-impairs-cutaneous-wound-healing-via-stimulating-macrophage-polarization-to-m1-in-diabetes
#6
Yuanyuan Guo, Cai Lin, Peng Xu, Shan Wu, Xiujun Fu, Weidong Xia, Min Yao
Autophagy is essential in physiological and pathological processes, however, the role of autophagy in cutaneous wound healing and the underlying molecular mechanism remain elusive. We hypothesized that autophagy plays an important role in regulating wound healing. Here, we show that enhanced autophagy negatively impacts on normal cutaneous healing process and is related to chronic wounds as demonstrated by the increased LC3 in diabetic mice skin or patients' chronic wounds. In addition, inhibition of autophagy by 3-MA restores delayed healing in C57BL/6 or db/db mice, demonstrating that autophagy is involved in regulating wound healing...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27783390/age-and-sex-distributions-of-age-related-biomarker-values-in-healthy-older-adults-from-the-long-life-family-study
#7
Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Lawrence S Honig, Nicole Schupf, Stephanie Cosentino, Mary F Feitosa, Mary Wojczynski, Anne B Newman, Monty Montano, Thomas T Perls
OBJECTIVES: To determine reference values for laboratory tests in individuals aged 85 and older. DESIGN: Cross-sectional cohort study. SETTING: International. PARTICIPANTS: Long Life Family Study (LLFS) participants (N~5,000, age: range 25-110, median 67, 45% male). MEASUREMENTS: Serum biomarkers were selected based on association with aging-related diseases and included complete blood count, lipids (triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol), 25-hydroxyvitamin D2 and D3, vitamin D epi-isomer, diabetes mellitus-related biomarkers (adiponectin, insulin, insulin-like growth factor 1, glucose, glycosylated hemoglobin, soluble receptor for advanced glycation endproduct), kidney disease-related biomarkers (albumin, creatinine, cystatin), endocrine biomarkers (dehydroepiandrosterone, sex-hormone binding globulin, testosterone), markers of inflammation (interleukin 6, high-sensitivity C-reactive protein, N-terminal pro b-type natriuretic peptide), ferritin, and transferrin...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27776915/reduction-in-ins-7-gene-expression-in-non-neuronal-cells-of-high-glucose-exposed-caenorhabditis-elegans-protects-from-reactive-metabolites-preserves-neuronal-structure-and-head-motility-and-prolongs-lifespan
#8
Michael Mendler, Christin Riedinger, Andrea Schlotterer, Nadine Volk, Thomas Fleming, Stephan Herzig, Peter P Nawroth, Michael Morcos
BACKGROUND: Glucose derived metabolism generates reactive metabolites affecting the neuronal system and lifespan in C. elegans. Here, the role of the insulin homologue ins-7 and its downstream effectors in the generation of high glucose induced neuronal damage and shortening of lifespan was studied. RESULTS: In C. elegans high glucose conditions induced the expression of the insulin homologue ins-7. Abrogating ins-7 under high glucose conditions in non-neuronal cells decreased reactive oxygen species (ROS)-formation and accumulation of methylglyoxal derived advanced glycation endproducts (AGEs), prevented structural neuronal damage and normalised head motility and lifespan...
October 1, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27760316/hmgb1-activates-proinflammatory-signaling-via-tlr5-leading-to-allodynia
#9
Nabanita Das, Varun Dewan, Peter M Grace, Robin J Gunn, Ryo Tamura, Netanel Tzarum, Linda R Watkins, Ian A Wilson, Hang Yin
Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced glycation endproducts) in inflammatory conditions. Here, we find that TLR5 is also an HMGB1 receptor that was previously overlooked due to lack of functional expression in the cell lines usually used for studying TLR signaling. HMGB1 binding to TLR5 initiates the activation of NF-κB signaling pathway in a MyD88-dependent manner, resulting in proinflammatory cytokine production and pain enhancement in vivo...
October 18, 2016: Cell Reports
https://www.readbyqxmd.com/read/27734162/insights-into-binding-of-s100-proteins-to-scavenger-receptors-class-b-scavenger-receptor-cd36-binds-s100a12-with-high-affinity
#10
Christoph Tondera, Markus Laube, Jens Pietzsch
The EF-hand type calcium-binding protein S100A12 exerts numerous intra- and extracellular functions of (patho)physiological relevance. Therefore, receptors of S100A12 are of high interest for research and clinical applications. Beside the extensively studied receptor for advanced glycation endproducts (RAGE), G-protein coupled receptors and more recently, scavenger receptors are suggested to be putative S100A12 receptors. Own findings and further information from the literature predestined CD36, a class B scavenger receptor, as promising candidate...
October 12, 2016: Amino Acids
https://www.readbyqxmd.com/read/27720951/ligand-binding-affinity-and-changes-in-the-lateral-diffusion-of-receptor-for-advanced-glycation-endproducts-rage
#11
Aleem Syed, Qiaochu Zhu, Emily A Smith
The effect of ligand on the lateral diffusion of receptor for advanced glycation endproducts (RAGE), a receptor involved in numerous pathological conditions, remains unknown. Single particle tracking experiments that use quantum dots specifically bound to hemagglutinin (HA)-tagged RAGE (HA-RAGE) are reported to elucidate the effect of ligand binding on HA-RAGE diffusion in GM07373 cell membranes. The ligand used in these studies is methylglyoxal modified-bovine serum albumin (MGO-BSA) containing advanced glycation end products modifications...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27687139/inhibitory-actions-of-selected-natural-substances-on-formation-of-advanced-glycation-endproducts-and-advanced-oxidation-protein-products
#12
Ewa Grzebyk, Agnieszka Piwowar
BACKGROUND: Advanced glycation endproducts (AGE) and advanced oxidation protein products (AOPP) arise as a result of excessive glycation and oxidation processes of proteins in hyperglycemia and oxidative stress conditions respectively, both in vivo and in vitro. In vivo these processes are especially intensified in patients with diabetes, and the adverse effects of AGE and AOPP are particularly unfavorable for the pathogenesis and aggravate the biochemical disturbances and clinical complications of diabetes...
September 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27684203/how-to-study-basement-membrane-stiffness-as-a-biophysical-trigger-in-prostate-cancer-and-other-age-related-pathologies-or-metabolic-diseases
#13
Mercedes Rodriguez-Teja, Claudia Breit, Mitchell Clarke, Kamil Talar, Kai Wang, Mohammad A Mohammad, Sage Pickwell, Guillermina Etchandy, Graeme J Stasiuk, Justin Sturge
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular disease, retinopathy, nephropathy and neuropathy). The premise of the model is non-enzymatic crosslinking of reconstituted BM (rBM) matrix by treatment with glycolaldehyde (GLA) to promote advanced glycation endproduct (AGE) generation via the Maillard reaction...
September 20, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27672697/chemical-synthesis-of-peptides-containing-site-specific-advanced-glycation-endproducts
#14
Harveen Kaur, Meder Kamalov, Margaret A Brimble
In nature, proteins, lipids, and nucleic acids can nonenzymatically react with sugars and sugar degradation products to give rise to a diverse range of modifications, known as advanced glycation endproducts (AGEs). These AGEs typically occur at lysine and arginine residues of long-lived proteins, such as collagen, and can modify the structure and function of the native protein. AGEs accumulate during the normal aging process, and AGE formation is dramatically accelerated with diabetes. AGEs have also been implicated in a wide range of debilitating conditions including cardiovascular, renal failure, and neurodegenerative diseases...
October 18, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27664677/effect-of-hydroxytyrosol-and-olive-leaf-extract-on-1-2-dicarbonyl-compounds-hydroxymethylfurfural-and-advanced-glycation-endproducts-in-a-biscuit-model
#15
Marta Navarro, Francisco J Morales
The antiglycative activity of hydroxytyrosol (HT) and olive leaf extract (OLE) was investigated in wheat-flour biscuits. Quercetin (QE) and gallic acid (GA) were used as reference of antiglycative activity of phenolic compounds. HT, OLE, QE and GA were added in the range of 0.25-0.75% (w/w). Samples were compared against a control recipe baked at 180°C/20min. HT biscuit was able to inhibit efficiently the formation of hydroxymethylfurfural (HMF) and 3-deoxyglucosone (3-DG), as well as reduced the formation of overall free fluorescent AGEs and pentosidine...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27662820/advanced-glycation-endproducts-impair-endothelial-progenitor-cell-migration-and-homing-via-syndecan-4-shedding
#16
Jun Xie, Ran Li, Han Wu, Jianzhou Chen, Guannan Li, Qinhua Chen, Zhonghai Wei, Guixin He, Lian Wang, Albert Ferro, Biao Xu
Endothelial progenitor cells (EPCs) are a subtype of bone marrow-derived progenitor cells. Stromal cell-derived factor 1 (SDF-1)-mediated EPC mobilization from bone marrow to areas of ischemia plays an important role in angiogenesis. Previous studies have reported that advanced glycation endproducts (AGEs), which are important mediators of diabetes-related vascular pathology, may impair EPC migration and homing, but the mechanism is unclear. Syndecan-4 (synd4) is a ubiquitous heparan sulfate proteoglycan receptor on the cell surface, involved in SDF-1-dependent cell migration...
September 24, 2016: Stem Cells
https://www.readbyqxmd.com/read/27658727/mechanisms-of-diabetes-mellitus-induced-bone-fragility
#17
REVIEW
Nicola Napoli, Manju Chandran, Dominique D Pierroz, Bo Abrahamsen, Ann V Schwartz, Serge L Ferrari
The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in T2DM is often normal or even slightly elevated compared with an age-matched control population. However, in both T1DM and T2DM, bone turnover is decreased and the bone material properties and microstructure of bone are altered; the latter particularly so when microvascular complications are present. The pathophysiological mechanisms underlying bone fragility in diabetes mellitus are complex, and include hyperglycaemia, oxidative stress and the accumulation of advanced glycation endproducts that compromise collagen properties, increase marrow adiposity, release inflammatory factors and adipokines from visceral fat, and potentially alter the function of osteocytes...
September 23, 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27585435/nutritional-supplements-modulate-fluorescent-protein-bound-advanced-glycation-endproducts-and-digestive-enzymes-related-to-type-2-diabetes-mellitus
#18
Emily R Koch, Permal Deo
BACKGROUND: Chronic hyperglycemia enhances the formation of advanced glycation endproducts (AGEs) and reactive oxygen species (ROS), contributing to diabetic complications. Thus, controlling blood glucose levels, inhibiting the formation of AGEs and reducing ROS are key therapeutic targets in early stage type 2 diabetes. METHODS: The inhibitory effects of seven commercial liquid nutritional supplements against carbohydrate hydrolysing enzymes, α-amylase and α-glucosidase, was determined by dinitrosalicylic (DNS) reagent and p-nitrophenyl-α-D-glucopyranoside solution, respectively...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27561727/adipose-recruitment-and-activation-of-plasmacytoid-dendritic-cells-fuel-metaflammation
#19
Amrit Raj Ghosh, Roopkatha Bhattacharya, Shamik Bhattacharya, Titli Nargis, Oindrila Rahaman, Pritam Duttagupta, Deblina Raychaudhuri, Chinky Shiu Chen Liu, Shounak Roy, Parasar Ghosh, Shashi Khanna, Tamonas Chaudhuri, Om Tantia, Stefan Haak, Santu Bandyopadhyay, Satinath Mukhopadhyay, Partha Chakrabarti, Dipyaman Ganguly
In obese individuals the visceral adipose tissue (VAT) becomes seat of chronic low grade inflammation (metaflammation). But the mechanistic link between increased adiposity and metaflammation remains largely unclear. We report here that in obese individuals deregulation of a specific adipokine, chemerin, contributes to innate initiation of metaflammation, by recruiting circulating plasmacytoid dendritic cells (pDCs) into visceral adipose tissue via chemokine-like receptor 1 (CMKLR1). Adipose tissue-derived high mobility group B1 (HMGB1) protein, activates toll-like receptor 9 (TLR9) in the adipose-recruited pDCs by transporting extracellular DNA via receptor for advanced glycation endproducts (RAGE) and induces production of type I interferons...
August 25, 2016: Diabetes
https://www.readbyqxmd.com/read/27529340/the-course-of-skin-and-serum-biomarkers-of-advanced-glycation-endproducts-and-its-association-with-oxidative-stress-inflammation-disease-severity-and-mortality-during-icu-admission-in-critically-ill-patients-results-from-a-prospective-pilot-study
#20
John H Meertens, Hans L Nienhuis, Joop D Lefrandt, Casper G Schalkwijk, Kristiina Nyyssönen, Jack J M Ligtenberg, Andries J Smit, Jan G Zijlstra, D J Mulder
BACKGROUND: Advanced glycation end products (AGEs) have been implicated in multiple organ failure, predominantly via their cellular receptor (RAGE) in preclinical studies. Little is known about the time course and prognostic relevance of AGEs in critically ill human patients, including those with severe sepsis. OBJECTIVE: 1) To explore the reliability of Skin Autofluorescence (AF) as an index of tissue AGEs in ICU patients, 2) to compare its levels to healthy controls, 3) to describe the time course of AGEs and influencing factors during ICU admission, and 4) to explore their association with disease severity, outcome, and markers of oxidative stress and inflammation...
2016: PloS One
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