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Advanced glycation endproducts

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https://www.readbyqxmd.com/read/29142432/inhibition-of-glycation-induced-cytotoxicity-protein-glycation-and-activity-of-proteolytic-enzymes-by-extract-from-perovskia-atriplicifolia-roots
#1
Mehran Miroliaei, Akram Aminjafari, Sylwester Ślusarczyk, Izabela Nawrot-Hadzik, Mehdi Rahimmalek, Adam Matkowski
Background: Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs. Objective: The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137475/metformin-attenuates-myocardium-dicarbonyl-stress-induced-by-chronic-hypertriglyceridemia
#2
H Malinska, V Škop, J Trnovska, I Markova, P Svoboda, L Kazdova, M Haluzik
Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29136166/diabetes-induced-hyperglycemia-impairs-male-reproductive-function-a-systematic-review
#3
Constanze C Maresch, Dina C Stute, Marco G Alves, Pedro F Oliveira, David M de Kretser, Thomas Linn
BACKGROUND: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing...
November 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29127203/receptor-for-advanced-glycation-endproducts-mediates-sepsis-triggered-amyloid-%C3%AE-accumulation-tau-phosphorylation-and-cognitive-impairment
#4
Juciano Gasparotto, Carolina S Girardi, Nauana Somensi, Camila T Ribeiro, José C F Moreira, Monique Michels, Beatriz Sonai, Mariane Rocha, Amanda V Steckert, Tatiana Barichello, João Quevedo, Felipe Dal-Pizzol, Daniel P Gelain
Patients recovering from sepsis have higher rates of CNS morbidities associated with long-lasting impairment of cognitive functions, including neurodegenerative diseases. However, the molecular etiology of these sepsis-induced impairments is unclear. Here, we investigated the role of the receptor for advanced glycation end products (RAGE) in neuroinflammation, neurodegeneration-associated changes, and cognitive dysfunction arising after sepsis recovery. Adult Wistar rats underwent cecal ligation and perforation (CLP), and serum and brain (hippocampus and prefrontal cortex) samples were obtained at days 1, 15, and 30 after the CLP...
November 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29115637/effect-of-linguizhugan-decoction-on-neuroinflammation-and-expression-disorder-of-the-amyloid-%C3%AE-%C3%A2-related-transporters-rage-and-lrp%C3%A2-1-in-a-rat-model-of-alzheimer-s-disease
#5
Qianfeng Hu, Beibei Yu, Qinlei Chen, Yi Wang, Yun Ling, Songxian Sun, Yinlong Shi, Chunxiang Zhou
Linguizhugan decoction (LGZG), a notable prescription in Traditional Chinese Medicine, is a classical formula for the treatment of Alzheimer's disease (AD), inflammatory injury and fluid retention. The present study aimed to investigate the neuroprotective effect of LGZG on an amyloid β (Aβ)‑induced AD rat model. Sprague‑Dawley rats were administered with Aβ1‑42 to induce AD and inflammatory responses, and subsequently with LGZG (4.8, 2.4 or 1.2 g/kg), donepezil (2 mg/kg) or distilled water for 30 consecutive days...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29053168/fl-926-16-a-novel-bioavailable-carnosinase-resistant-carnosine-derivative-prevents-onset-and-stops-progression-of-diabetic-nephropathy-in-db-db-mice
#6
Carla Iacobini, Stefano Menini, Claudia Blasetti Fantauzzi, Carlo M Pesce, Andrea Giaccari, Enrica Salomone, Annunziata Lapolla, Marica Orioli, Giancarlo Aldini, Giuseppe Pugliese
BACKGROUND AND PURPOSE: The advanced glycation endproducts (AGEs) participate in the pathogenesis of diabetic nephropathy (DN) by promoting renal inflammation and injury. L-carnosine acts as a quencher of the AGE precursors reactive carbonyl species (RCS), but it is rapidly inactivated by carnosinase. This study evaluated the effect of FL-926-16, a carnosinase-resistant and bioavailable carnosine derivative, on the onset and progression of DN in db/db mice. EXPERIMENTAL APPROACH: Adult male db/db mice and coeval db/m controls were left untreated or treated with FL-926-16 (30 mg·kg(-1) body weight) from week 6 to 20 (prevention protocol) or from week 20 to 34 (regression protocol)...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29021368/spontaneous-pmn-apoptosis-in-type-2-diabetes-and-the-impact-of-periodontitis
#7
Aggasit Manosudprasit, Alpdogan Kantarci, Hatice Hasturk, Danielle Stephens, Thomas E Van Dyke
The purpose of this study was to test the hypothesis that peripheral blood neutrophils (PMN) exhibit delayed spontaneous apoptosis in individuals with diabetes mellitus type 2 (T2DM) and that the delay is exacerbated further among people who coexpress chronic periodontitis (CP). Seventy-three individuals were enrolled, including those with T2DM (n = 16), CP (n = 15), T2DM + CP (n = 21), and healthy volunteers (n = 21). PMN apoptosis was determined by flow cytometry using TUNEL and Annexin V assays. The activity of caspase-3, -8, and -9 was measured by colorimetric assay...
October 11, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29018354/n-acetylcysteine-counteracts-adipose-tissue-macrophage-infiltration-and-insulin-resistance-elicited-by-advanced-glycated-albumin-in-healthy-rats
#8
Karolline S da Silva, Paula R Pinto, Nelly T Fabre, Diego J Gomes, Karina Thieme, Ligia S Okuda, Rodrigo T Iborra, Vanessa G Freitas, Maria H M Shimizu, Walcy R Teodoro, Suely K N Marie, Tom Woods, Margaret A Brimble, Russell Pickford, Kerry-Anne Rye, Maristela Okamoto, Sergio Catanozi, Maria L Correa-Giannela, Ubiratan F Machado, Marisa Passarelli
Background: Advanced glycation endproducts elicit inflammation. However, their role in adipocyte macrophage infiltration and in the development of insulin resistance, especially in the absence of the deleterious biochemical pathways that coexist in diabetes mellitus, remains unknown. We investigated the effect of chronic administration of advanced glycated albumin (AGE-albumin) in healthy rats, associated or not with N-acetylcysteine (NAC) treatment, on insulin sensitivity, adipose tissue transcriptome and macrophage infiltration and polarization...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28990237/dereplication-by-hplc-dad-esi-ms-ms-and-screening-for-biological-activities-of-byrsonima-species-malpighiaceae
#9
Karina Fraige, Alessandra Cristina Dametto, Maria Luiza Zeraik, Larissa de Freitas, Amanda Correia Saraiva, Alexandra Ivo Medeiros, Ian Castro-Gamboa, Alberto José Cavalheiro, Dulce Helena S Silva, Norberto Peporine Lopes, Vanderlan S Bolzani
INTRODUCTION: Byrsonima species have been used in the treatment of gastrointestinal and gynecological inflammations, skin infections and snakebites. Based on their biological activities, it is important to study other organisms from this genus and to identify their metabolites. OBJECTIVES: To determine the metabolic fingerprinting of methanol and ethyl acetate extracts of four Byrsonima species (B. intermedia, B. coccolobifolia, B. verbascifolia and B. sericea) by HPLC-DAD-ESI-MS/MS and evaluate their in vitro antioxidant, anti-glycation, anti-inflammatory and cytotoxic activities...
October 9, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28971147/statins-decrease-vascular-epithelial-growth-factor-expression-via-down-regulation-of-receptor-for-advanced-glycation-end-products
#10
Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Ryogo Shobatake, Mai Makino, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata
AIMS: Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, possess pleiotropic effects that have been extended to modulation of various cellular behaviors. This study aimed to examine whether statins modulate vascular endothelial growth factor A (VEGF-A) expression in human retinal pigment epithelium (RPE) cells. MAIN METHODS: Human RPE cells (h1RPE7), damaged by hydroquinone (HQ) + advanced glycation endproducts (AGE) in an in vitro AMD model, were treated with atorvastatin or lovastatin for 24 h...
September 2017: Heliyon
https://www.readbyqxmd.com/read/28947744/therapeutic-effectiveness-of-anti-rage-antibody-administration-in-a-rat-model-of-crush-injury
#11
Hisatake Matsumoto, Naoya Matsumoto, Junya Shimazaki, Junichiro Nakagawa, Yukio Imamura, Kazuma Yamakawa, Tomoki Yamada, Mitsunori Ikeda, Hiroko Hiraike, Hiroshi Ogura, Takeshi Shimazu
Crush injury patients often have systemic inflammatory response syndrome that leads to multiple organ failure. Receptor for advanced glycation endproducts (RAGE) functions as a pattern recognition receptor that regulates inflammation. We evaluated the effects of anti-RAGE antibody in a crush injury model. Pressure was applied to both hindlimbs of rats for 6 h by 3.0-kg blocks and then released. Animals were randomly divided into the sham (RAGE-Sh) group, crush (RAGE-Ctrl) group or anti-RAGE antibody-treated crush (RAGE-Tx) group...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28941024/serum-levels-of-hmgb1-and-srage-are-associated-to-extraglandular-involvement-and-disease-activity-as-defined-by-essdai-in-sj%C3%A3-gren-s-syndrome
#12
Anna-Maria Kanne, Maike Jülich, Amira Mahmutovic, Isabella Tröster, Bettina Sehnert, Vilma Urbonaviciute, Reinhard E Voll, Florian Kollert
OBJECTIVE: To assess serum levels of high mobility group box 1 (HMGB1) and the soluble receptor for advanced glycation endproducts (sRAGE) in patients with Sjögren's Syndrome (SS) and explore correlations with disease activity. METHODS: Thirty-nine patients with SS and 21 healthy controls (HC) were included in this cross-sectional study. Clinical and laboratory values were obtained from all patients. Disease activity was assessed by European League against Rheumatism (EULAR) SS disease activity index (ESSDAI)...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28887039/activation-of-the-hmgb1-rage-axis-upregulates-th-expression-in-dopaminergic-neurons-via-jnk-phosphorylation
#13
Soo Jeong Kim, Min Jeong Ryu, Jeongsu Han, Yunseon Jang, Jungim Kim, Min Joung Lee, Ilhwan Ryu, Xianshu Ju, Eungseok Oh, Woosuk Chung, Gi Ryang Kweon, Jun Young Heo
The derangement of tyrosine hydroxylase (TH) activity reduces dopamine synthesis and is implicated in the pathogenesis of Parkinson's disease. However, the extracellular modulator and intracellular regulatory mechanisms of TH have yet to be identified. Recently, high-mobility group box 1 (HMGB1) was reported to be actively secreted from glial cells and is regarded as a mediator of dopaminergic neuronal loss. However, the mechanism for how HMGB1 affects TH expression, particularly through the receptor for advanced glycation endproducts (RAGE), has not yet been investigated...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28880548/transketolase-a-from-e-coli-significantly-suppresses-protein-glycation-by-glycolaldehyde-and-glyoxal-in-vitro
#14
Alexander Klaus, Thorsten Pfirrmann, Marcus A Glomb
Short-chained carbonyl species such as glycolaldehyde and its oxidized pendant glyoxal are highly reactive Maillard agents, leading to the formation of protein modifications. These advanced glycation endproducts have gained considerable interest as they have been linked to various pathologies in vivo. The ability of transketolase to use glycolaldehyde as a substrate suggested the possibility to modulate carbonyl-driven Maillard reactions. Model incubations with recombinant transketolase A from Escherichia coli in the presence of bovine serum albumin and glycolaldehyde indeed led to a decrease in glycolaldehyde concentrations paralleled by the enzymatic conversion to erythrulose...
September 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28859297/amyloidogenic-medin-induces-endothelial-dysfunction-and-vascular-inflammation-through-the-receptor-for-advanced-glycation-endproducts
#15
Raymond Q Migrino, Hannah A Davies, Seth Truran, Nina Karamanova, Daniel A Franco, Thomas G Beach, Geidy E Serrano, Danh Truong, Mehdi Nikkhah, Jillian Madine
Aims: Medin is a common amyloidogenic protein in humans that accumulates in arteries with advanced age and has been implicated in vascular degeneration. Medin's effect on endothelial function remains unknown. The aims are to assess medin's effects on human arteriole endothelial function and identify potential mechanisms underlying medin-induced vascular injury. Methods and results: Ex vivo human adipose and leptomeningeal arterioles were exposed (1 h) to medin (0...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28857681/expression-and-purification-of-the-extracellular-domains-of-human-glycoprotein-vi-gpvi-and-the-receptor-for-advanced-glycation-end-products-rage-from-rattus-norvegicus-in-leishmania-tarentolae
#16
Thomas Langer, Carsten Corvey, Katja Kroll, Oliver Boscheinen, Thomas Wendrich, Werner Dittrich
Glycosylation is one of the most complex post-translational modifications and may have significant influence on the proper function of the corresponding proteins. Bacteria and yeast are, because of easy handling and cost reasons, the most frequently used systems for recombinant protein expression. Bacteria generally do not glycosylate proteins and yeast might tend to hyperglycosylate. Insect cell- and mammalian cell-based expression systems are able to produce complex N-glycosylation structures but are more complex to handle and more expensive...
August 31, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28840833/the-anti-inflammatory-and-anti-glycative-effects-of-rosmarinic-acid-in-the-livers-of-type-1-diabetic-mice
#17
Yu-Ju Wen, Mei-Chin Yin
BACKGROUND: Rosmarinic acid (RA) is a polyphenol present in members of the Lamiaceae family. In this study, yhe anti-inflammatory and anti-glycative effects of RA in the livers of type 1 diabetic mice were examined. METHODS: The diabetic mice were divided into three groups: diabetic mice with 0, low dose RA (25 mg/ml), and high dose RA (50 mg/ml). One group of non-diabetic mice was used as a control for comparison. RA was supplied via daily 200 μL oral injections for 9 weeks...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28834384/association-of-s100-calcium-binding-protein-a12-receptor-for-advanced-glycation-endproducts-and-nuclear-factor-%C3%AE%C2%BAb-expression-with-inflammation-in-pulp-tissues-from-tooth-caries
#18
Mohammad M Y Khorasani, Pouria Andam-Shahsavari, Nahid Zainodini, Hossein Khoramdelazad, Reza Nosratabadi
AIM: S100 calcium-binding protein A1 (S100A12) is a pro-inflammatory molecule which is secreted during inflammation and induces chemotaxis and the production of pro-inflammatory cytokines via interaction with receptor for advanced glycation endproducts (RAGE) and subsequent, activation of nuclear factor-κB (NF-κB). The present study was designed to determine the expression levels of S100A12, RAGE, and NF-κB in the inflamed pulp of carried teeth. METHODS: In the present study, mRNA from 50 inflamed pulp and 50 healthy pulp were used for expression studies using real-time polymerase chain reaction...
August 20, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28821831/targeted-inhibition-of-rage-in-substantia-nigra-of-rats-blocks-6-ohda-induced-dopaminergic-denervation
#19
Juciano Gasparotto, Camila Tiefensee Ribeiro, Rafael Calixto Bortolin, Nauana Somensi, Thallita Kelly Rabelo, Alice Kunzler, Natália Cabral Souza, Matheus Augusto de Bittencourt Pasquali, José Claudio Fonseca Moreira, Daniel Pens Gelain
The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the expression of proinflammatory mediators and its own expression via activation of NF-kB. Recent works have proposed a role for RAGE in Parkinson's disease (PD). In this study, we used the multimodal blocker of RAGE FPS-ZM1, which has become available recently, to selectively inhibit RAGE in the substantia nigra (SN) of rats intracranially injected with 6-hydroxydopamine (6-OHDA)...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811295/circulating-soluble-rage-isoforms-are-attenuated-in-obese-impaired-glucose-tolerant-individuals-and-are-associated-with-the-development-of-type-2-diabetes
#20
Edwin R Miranda, Vikram S Somal, Jacob T Mey, Brian K Blackburn, Edward Wang, Sarah S Farabi, Kristian Karstoft, Ciaran E Fealy, Sangeeta R Kashyap, John P Kirwan, Laurie Quinn, Thomas P J Solomon, Jacob M Haus
The soluble receptor for advanced glycation endproducts (sRAGE) may be protective against inflammation associated with obesity and type 2 diabetes (T2DM). The aim of this study was to determine the distribution of sRAGE isoforms, and whether sRAGE isoforms are associated with risk of T2DM development in subjects spanning the glucose tolerance continuum. In this retrospective analysis, circulating total sRAGE and endogenous secretory RAGE (esRAGE) were quantified via ELISA and cleaved RAGE (cRAGE) was calculated in 274 individuals stratified by glucose tolerance status (GTS) and obesity...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
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