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Inhibition of glycation

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https://www.readbyqxmd.com/read/29351482/suppression-of-gut-dysbiosis-reverses-western-diet-induced-vascular-dysfunction
#1
Micah L Battson, Dustin M Lee, Dillon K Jarrell, Shuofei Hou, Kayl E Ecton, Tiffany L Weir, Christopher L Gentile
OBJECTIVE: Vascular dysfunction represents a critical pre-clinical step in the development of cardiovascular disease. We examined the role of the gut microbiota in the development of obesity-related vascular dysfunction. Approach and Results. Male C57BL/6J mice were fed either a standard diet (SD) (n=12) or western diet (WD) (n=24) for 5m, after which time, WD mice were randomized to receive either un-supplemented drinking water or water containing a broad-spectrum antibiotic cocktail (WD+Abx) (n=12/group) for 2m...
December 26, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29348870/n%C3%AE%C2%B5-carboxymethyl-lysine-promotes-calcium-deposition-in-vsmcs-via-intracellular-oxidative-stress-induced-pdk4-activation-and-alters-glucose-metabolism
#2
Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
Diabetes and vascular calcification are intrinsically linked. We previously reported that advanced glycation end products (AGEs) accelerate calcium deposition in vascular smooth muscle cells (VSMCs) via excessive oxidative stress. However, the underlying mechanism remains poorly understood. Pyruvate dehydrogenase kinase 4 (PDK4) is an important mitochondrial matrix enzyme in cellular energy metabolism. Since hyperactivation of PDK4 has been reported in calcified vessels and in patients with diabetes mellitus, inhibition of PDK4 expression may be a strategy for the prevention of diabetic vascular calcification...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29343652/painless-thyroiditis-and-fulminant-type-1-diabetes-mellitus-in-a-patient-treated-with-an-immune-checkpoint-inhibitor-nivolumab
#3
Kanako Sakurai, Satsuki Niitsuma, Ryota Sato, Kazuhiro Takahashi, Zenei Arihara
The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. Nivolumab, an anti-PD-1 monoclonal antibody, blocks PD-1 and can restore anti-cancer immune responses by disrupting the signal that inhibits T-cell activation. Nivolumab may induce endocrine-related adverse events, including hypophysitis, autoimmune thyroiditis, and type 1 diabetes mellitus. Here we report a 68-year-old female patient with advanced renal cell carcinoma who was treated with nivolumab...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29337308/rage-binds-preamyloid-iapp-intermediates-and-mediates-pancreatic-%C3%AE-cell-proteotoxicity
#4
Andisheh Abedini, Ping Cao, Annette Plesner, Jinghua Zhang, Meilun He, Julia Derk, Sachi A Patil, Rosa Rosario, Jacqueline Lonier, Fei Song, Hyunwook Koh, Huilin Li, Daniel P Raleigh, Ann Marie Schmidt
Islet amyloidosis is characterized by the aberrant accumulation of islet amyloid polypeptide (IAPP) in pancreatic islets, resulting in β cell toxicity, which exacerbates type 2 diabetes and islet transplant failure. It is not fully clear how IAPP induces cellular stress or how IAPP-induced toxicity can be prevented or treated. We recently defined the properties of toxic IAPP species. Here, we have identified a receptor-mediated mechanism of islet amyloidosis-induced proteotoxicity. In human diabetic pancreas and in cellular and mouse models of islet amyloidosis, increased expression of the receptor for advanced glycation endproducts (RAGE) correlated with human IAPP-induced (h-IAPP-induced) β cell and islet inflammation, toxicity, and apoptosis...
January 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29334926/-r-%C3%AE-lipoic-acid-inhibits-fructose-induced-myoglobin-fructation-and-the-formation-of-advanced-glycation-end-products-ages-in-vitro
#5
Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada, Srinivas Nammi
BACKGROUND: Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objective of the present study is to evaluate the protective effect of (R)-α-lipoic acid (ALA) against fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro. METHODS: The anti-glycation activity of ALA was determined using the formation of AGEs fluorescence intensity, iron released from the heme moiety of myoglobin and the level of fructosamine...
January 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29331868/zinc-supplementation-alleviates-the-progression-of-diabetic-nephropathy-by-inhibiting-the-overexpression-of-oxidative-stress-mediated-molecular-markers-in-streptozotocin-induced-experimental-rats
#6
Susmita Barman, Seetur R Pradeep, Krishnapura Srinivasan
Zinc deficiency during diabetes projects a role for zinc nutrition in the management of diabetic nephropathy. The current study explored whether zinc supplementation protects against diabetic nephropathy through modulation of kidney oxidative stress and stress-induced expression related to the inflammatory process in streptozotocin-induced diabetic rats. Groups of hyperglycemic rats were exposed to dietary interventions for 6 weeks with zinc supplementation (5 times and 10 times the normal level). Supplemental-zinc-fed diabetic groups showed a significant reversal of increased kidney weight and creatinine clearance...
December 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29329433/rage-mediates-a%C3%AE-accumulation-in-a-mouse-model-of-alzheimer-s-disease-via-modulation-of-%C3%AE-and-%C3%AE-secretase-activity
#7
Fang Fang, Qing Yu, Ottavio Arancio, Doris Chen, Smruti S Gore, Shi Fang Yan, Shirley ShiDu Yan
Receptor for Advanced Glycation End products (RAGE) has been implicated in amyloid β-peptide (Aβ)-induced perturbation relevant to the pathogenesis of Alzheimer's disease (AD). However, whether and how RAGE regulates Aβ metabolism remains largely unknown. Aβ formation arises from aberrant cleavage of amyloid precursor protein (APP) by β- and γ-secretase. To investigate whether RAGE modulates β- and γ-secretase activity potentiating Aβ formation, we generated mAPP mice with genetic deletion of RAGE (mAPP/RO)...
January 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29322013/dillenia-indica-l-attenuates-diabetic-nephropathy-via-inhibition-of-advanced-glycation-end-products-accumulation-in-stz-nicotinamide-induced-diabetic-rats
#8
Navpreet Kaur, Lalit Kishore, Randhir Singh
The present study was aimed to evaluate advanced glycation end products (AGEs) inhibitory activity of alcohol and hydro-alcohol extract (DAE and DHE) of Dillenia indica L. (Family: Dilleniaceae) and its potential in treatment of diabetic nephropathy by targeting markers of oxidative stress. D. indica was evaluated for its in vitro inhibitory activity against formation of AGEs by using bovine serum albumin. Diabetes was induced in male Wistar rats by streptozotocin (65 mg/kg i.p.) 15 min after nicotinamide (230 mg/kg, i...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29301761/uremic-advanced-glycation-end-products-and-protein-bound-solutes-induce-endothelial-dysfunction-through-suppression-of-kr%C3%A3-ppel-like-factor-2
#9
Keith Saum, Begoña Campos, Diego Celdran-Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy-Chaudhury, A Phillip Owens
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated cardiovascular disease. In this study, we examined the impact of the uremic milieu on the endothelial transcription factor, Krüppel-like factor 2 (KLF2), a key regulator of endothelial function and activation. METHODS AND RESULTS: Using serum from uremic pigs with chronic renal insufficiency, our results show that KLF2 expression is suppressed by the uremic milieu and individual uremic solutes in vitro...
January 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#10
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29299203/memory-enhancement-and-protective-effects-of-crocin-against-d-galactose-aging-model-in-the-hippocampus-of-wistar-rats
#11
Somaye Heidari, Soghra Mehri, Hossein Hosseinzadeh
Objectives: The neurodegeneration and loss of memory function are common consequences of aging. Medicinal plants have potent protective effects against chronic neurodegenerative diseases. The aim of this study was to investigate the beneficial effects and molecular mechanisms of crocin on brain function in D-galactose (D-gal)-induced aging model in rats. Materials and Methods: Male Wistar rats weighing 220 ± 20 g were randomly divided into six groups: control, D-gal (400 mg/kg, SC), D-gal (400 mg/kg) plus crocin (7...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29298878/ager-promotes-proliferation-and-migration-in-cervical-cancer
#12
Xuejie Zhu, Lulu Zhou, Ruyi Li, Qi Shen, Huihui Cheng, Zongji Shen, Haiyan Zhu
Advanced Glycation End-products Specific receptor for (AGER) is an oncogenic trans-membranous receptor up-regulated in various human cancers. We have previously reported that AGER was over-expressed in squamous cervical cancer. However, mechanisms of AGER involved in progression of cervical cancer are unknown. In this study, we investigated the effects of AGER on biological behavior, including proliferation, apoptosis, and migration using multiple biological approaches. AGER protein primarily localized in the cytoplasm and cytomembrane of cervical squamous cancer cells...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29291586/new-insights-into-the-efficiency-of-thymol-synergistic-effect-with-p-cymene-in-inhibiting-advanced-glycation-end-products-a-multi-way-analysis-based-on-spectroscopic-and-electrochemical-methods-in-combination-with-molecular-docking-study
#13
Saleheh Abbasi, Sajjad Gharaghani, Ali Benvidi, Masoud Rezaeinasab
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glycation process with basic chemometric frameworks. The aim of the current study is to investigate the anti-glycation effects of candidate compounds from thyme species i.e. thymol and p-cymene. To gain this objective, the electrochemical and absorption responses of glycated bovine serum albumin (BSA) in the absence and presence of inhibitors were recorded after 20 day of incubation...
December 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29287468/effect-of-maize-bran-feruloylated-oligosaccharides-on-the-formation-of-endogenous-contaminants-and-the-appearance-and-textural-properties-of-biscuits
#14
Junqing Huang, Yijinruo Wang, Ling Yang, Xichun Peng, Jie Zheng, Shiyi Ou
Feruloylated oligosaccharides (FOs) have been approved by the US Food and Drug Administration for addition to baked goods. This work investigated the effect of FOs on the formation of endogenous contaminants, antioxidant properties, appearance and texture of biscuits. FOs inhibited the formation of fluorescent AGEs (advanced glycation end-products), protein oxidation products, and dicarbonyl compounds in a dose-dependent manner. Addition of 10 mg/g FOs decreased the levels of fluorescent AGEs, dityrosine, kynurenine, N'-formylkynurenine, 3-deoxyglucosone, glyoxal, and methylglyoxal by 80%, 97%, 56%, 86%, 46%, 54% and 62%, respectively...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29278639/pioglitazone-attenuates-atherosclerosis-in-diabetic-mice-by-inhibition-of-receptor-for-advanced-glycation-end-product-rage-signaling
#15
Hongli Gao, Hongwei Li, Weiping Li, Xuhua Shen, Beibing Di
BACKGROUND Peroxisome proliferator-activated receptor-g (PPAR-g) exhibits anti-inflammatory and anti-diabetic properties, and is protective against cardiovascular diseases. This study aimed to determine the effects of a PPAR-g agonist pioglitazone on atherogenesis in an ApoE knockout mouse (ApoE-/-) diabetic mouse model and in a cultured vascular smooth muscle cells (VSMCs) model. MATERIAL AND METHODS Male ApoE-/- mice were rendered diabetic by 5 daily intraperitoneal injections of streptozotocin. Pioglitazone (20 mg/kg/d) or PPAR-γ inhibitor GW9662 (1 mg/kg/d) were administered for 12 weeks...
December 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29276489/multi-protection-of-dl0410-in-ameliorating-cognitive-defects-in-d-galactose-induced-aging-mice
#16
Wenwen Lian, Hao Jia, Lvjie Xu, Wei Zhou, De Kang, Ailin Liu, Guanhua Du
D-galactose has been reported to accelerate senescence in rodents, accompanied by a decline in learning and memory. We used a model of D-galactose-induced amnesia for the efficacy evaluation and pharmacologic studies of active compounds against Alzheimer's disease (AD). DL0410 is a potent inhibitor against acetylcholinesterase (AChE) and, in the present study, the effect of DL0410 was evaluated in this model. We found that DL0410 could significantly improve the learning and memory of D-galactose induced aging mice in a series of behavioral tests: novel-object recognition test, nest-building test, Morris water maze test and step-through test...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29274622/inhibition-of-the-receptor-for-advanced-glycation-promotes-proliferation-and-repair-of-human-periodontal-ligament-fibroblasts-in-response-to-high-glucose-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#17
Danting Zhan, Ling Guo, Lige Zheng
OBJECTIVE: To observe if inhibition of the receptor for advanced glycation endproducts (RAGE) promotes proliferation and repair of human periodontal ligament fibroblasts (hPDLFs) stimulated by high glucose. In addition, we also discuss the effects of the NF-κB signaling pathway in relation to this process. METHODS: Primary cultured hPDLFs were exposed to either low glucose (5.5 mmol/L) or high glucose (25 mmol/L), and RAGE expression was measured by Western blot analysis...
December 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29273414/bioactive-chemical-constituents-of-duboscia-macrocarpa-bocq-and-x-ray-diffraction-study-of-11%C3%AE-12%C3%AE-epoxyfriedours-14-en-3%C3%AE-ol
#18
Ramsay S T Kamdem, Pascal Wafo, Amadou Dawe, Dieu Ne Dort Nganteng, Umeokoli Blessing Ogechukwu, Saima Rasheed, Omeje E Ogechukwu, Gamall Makhloufi, Zulfiqar Ali, Ikhlas A Khan, Muhammad Iqbal Choudhary, Christoph Janiak, Peter Proksch
A new γ-lactone triterpenoid, Evodoulolide (1) and a new triterpenoid Duboscic acid B (2), along with five known compounds, maslinic acid (3), arboreic acid (4), (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl) ethyl] prop-2-enamide (5), (E)-heptacos-19-enoic acid (6) and 11β,12β-epoxyfriedours-14-en-3α-ol (7) were isolated from the trunk wood of Duboscia macrocarpa. Their structures were elucidated from extensive 1D- and 2D-NMR and MS and by comparison of their spectra with published data. Compounds 1, 3, 5 and 6 exhibited significant α-glucosidase inhibitory activity...
December 19, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29262395/salvianolic-acid-a-protects-against-diabetic-nephropathy-through-ameliorating-glomerular-endothelial-dysfunction-via-inhibiting-age-rage-signaling
#19
Biyu Hou, Guifen Qiang, Yuerong Zhao, Xiuying Yang, Xi Chen, Yu Yan, Xiaobo Wang, Chenge Liu, Li Zhang, Guanhua Du
BACKGROUND/AIMS: Glomerular endothelium dysfunction leads to the progression of renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN). Advanced glycation end products (AGEs) and receptor for AGEs (RAGE) are proved to play important roles in diabetic nephropathy. This study investigated the role of Salvianolic acid A (SalA) on early-stage DN and its possible underlying mechanism. METHODS: In vitro AGEs formation and breaking rate were measured to illustrate the effect of SalA on AGEs...
December 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29248482/targeted-inhibition-of-rage-reduces-amyloid-%C3%AE-influx-across-the-blood-brain-barrier-and-improves-cognitive-deficits-in-db-db-mice
#20
Hao Wang, Fang Chen, Yi-Feng Du, Yan Long, Miranda N Reed, Mei Hu, Vishnu Suppiramaniam, Hao Hong, Su-Su Tang
AIMS: To investigate restorative effects of the receptor for advanced glycation end products (RAGE)-specific inhibitor FPS-ZM1 on abnormal amyloid (Aβ) influx across the blood brain-barrier (BBB) and cognitive deficits in db/db mice. METHODS: Aβ influx across the BBB was determined by intra-arterial infusion of 125I-Aβ1-40. Receptor for advanced glycation end products (RAGE), Aβ, NF-κB p65, caspase-3, Bax, Bcl-2, PSD-95 and synaptophysin were assayed by Western blot, immunohistochemistry or RT-PCR...
December 14, 2017: Neuropharmacology
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