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Inhibition of glycation

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https://www.readbyqxmd.com/read/29778537/a-new-indanedione-derivative-alleviates-symptoms-of-diabetes-by-modulating-rage-nf-kappab-pathway-in-db-db-mice
#1
Gulnaz Khan, Meha Fatima Aftab, Bilquees Bano, Khalid Mohammed Khan, Munazza Murtaza, Sonia Siddiqui, M Hafizur Rehman, Rizwana Sanaullah Waraich
Accumulating evidence indicates that a number of tissues are damaged due to build-up of abnormal amount of Advanced Glycation End products (AGEs) in several diseases including diabetes. Currently AGE inhibitors are scarce in clinical use indicating a need for development of new anti-AGE agents. The aim of the current study is to identify the new AGE inhibitors and to decipher their mechanism of action for alleviating symptoms of diabetes in mice. Among several derivatives, one of the derivatives of indanedione, IDD-24 demonstrated highest inhibition of AGE formation and AGE mediated reactive oxygen species production in HepG-2 and mature 3T3-L1 adipocytes...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777520/relationship-of-eating-patterns-and-metabolic-parameters-and-teneligliptin-treatment-interim-results-from-post-marketing-surveillance-in-japanese-type-2-diabetes-patients
#2
Takashi Kadowaki, Masakazu Haneda, Hiroshi Ito, Kazuyo Sasaki, Sonoe Hiraide, Miyuki Matsukawa, Makoto Ueno
INTRODUCTION: Healthy eating is a critical aspect of the prevention and management of type 2 diabetes (T2DM). Disrupted eating patterns can result in poor glucose control and increase the likelihood of diabetic complications. Teneligliptin inhibits dipeptidyl peptidase-4 activity for 24 h and suppresses postprandial hyperglycemia after all three daily meals. This interim analysis of data from the large-scale post-marketing surveillance of teneligliptin (RUBY) in Japan examined eating patterns and their relationship with metabolic parameters and diabetic complications...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29775571/effect-of-methylglyoxal-on-reactive-oxygen-species-ki-67-and-caspase-3-expression-in-mcf-7-cells
#3
Dyah Paramita, J D P Wisnubroto
BACKGROUND: Methylglyoxal (MG) is an extremely reactive α-ketoaldehyde endogenously produced by various metabolic pathways, including the dephosphorylation of glycolytic intermediates, metabolites of the polyol pathway, and aminoacetone metabolism. MG cytotoxicity occurs through the induction of apoptosis. There are multiple mechanisms by which MG can induce apoptosis, e.g., through the generation of reactive oxygen species (ROS), induction of oxidative DNA damage, or accumulation of a specific MG-derived advanced glycation end product (AGE)...
May 15, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29758985/ultrasonic-pretreatment-combined-with-dry-state-glycation-reduced-the-ige-igg-binding-ability-of-%C3%AE-lactalbumin-revealed-by-high-resolution-mass-spectrometry
#4
Jun Liu, Zong-Cai Tu, Guang-Xian Liu, Chen-di Niu, Hong-Lin Yao, Hui Wang, Xiao-Mei Sha, Yan-Hong Shao, Igor A Kaltashov
Bovine α-lactalbumin (α-LA) is one of major food allergens in cow's milk. The present work sought to research the effects of ultrasonic pretreatment combined with dry heating-induced glycation between α-LA and galactose on the IgE/IgG-binding ability and glycation extent of α-LA, which determined by inhibition ELISA and high-resolution mass spectrometry respectively. The IgE/IgG-binding ability of glycated α-LA were significantly decreased as a result of ultrasonic pretreatment, while average molecular weight, incorporation ratio (IR) value, the location and number of glycation site, and degree of substitution per peptide (DSP) value was elevated...
May 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29758984/the-inhibition-of-methylglyoxal-induced-histone-h1-n%C3%AE%C2%B5-carboxymethyllysine-formation-by-catechin
#5
Lijun Yang, Xinping Li, Zhaozhen Wu, Cuixia Feng, Tianyu Zhang, Shaohua Dai, Qiang Dong
Reactive dicarbonyl species (RCS) such as methylglyoxal (MGO) and glyoxal (GO) are common intermediates in protein damage, leading to the formation of advanced glycation end products (AGEs) through nonenzymatic glycation. (+)-Catechin, a natural plant extract from tea, has been evaluated for its ability in trapping GO and MGO. However, (+)-catechin also is reported to have both anti-oxidant ability and pro-oxidant properties. Till now, whether (+)-catechin can inhibit the formation and its mechanism in nucleoprotein nonenzymatic glycation is still unclear...
May 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29753380/chronic-alcohol-ingestion-impairs-rat-alveolar-macrophage-phagocytosis-via-disruption-of-rage-signaling
#6
Bashar S Staitieh, Eduardo E Egea, Xian Fan, Adaugo Amah, David M Guidot
BACKGROUND: Alcohol significantly impairs antioxidant defenses and innate immune function in the lung and increases matrix metalloproteinase 9 (MMP-9) activity. The receptor for advanced glycation end products (RAGE) is a well-characterized marker of lung injury that is cleaved by MMP-9 into soluble RAGE and has not yet been examined in the alcoholic lung. We hypothesized that chronic alcohol ingestion would impair RAGE signaling via MMP-9 in the alveolar macrophage and thereby impair innate immune function...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#7
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746877/liraglutide-attenuates-the-migration-of-retinal-pericytes-induced-by-advanced-glycation-end-products
#8
Wen-Jian Lin, Xue-Fei Ma, Ming Hao, Huan-Ran Zhou, Xin-Yang Yu, Ning Shao, Xin-Yuan Gao, Hong-Yu Kuang
Retinal pericyte migration represents a novel mechanism of pericyte loss in diabetic retinopathy (DR), which plays a crucial role in the early impairment of the blood-retinal barrier (BRB). Glucagon-like peptide-1 (GLP-1) has been shown to protect the diabetic retina in the early stage of DR; however, the relationship between GLP-1 and retinal pericytes has not been discussed. In this study, advanced glycation end products (AGEs) significantly increased the migration of primary bovine retinal pericytes without influencing cell viability...
May 7, 2018: Peptides
https://www.readbyqxmd.com/read/29744367/age-rage-induced-emp-release-via-the-nox-derived-ros-pathway
#9
Ying-Hua Chen, Zhang-Wei Chen, Hong-Mei Li, Xin-Feng Yan, Bo Feng
Objective: Diabetes is associated with accelerated formation of advanced glycation end products (AGEs) that are extensively found in circulating endothelial microparticles (EMPs). This study aimed to investigate whether AGEs have a direct effect on EMP formation and the possible underlying mechanism. Methods: In vitro, cultured human umbilical vein endothelial cells (HUVECs) were incubated with AGEs (200 and 400  μ g/ml) for 24 hours with or without pretreatment with anti-RAGE antibody, NOX inhibitor, or ROS scavenger...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29739591/in-vitro-health-promoting-properties-of-antioxidant-dietary-fiber-extracted-from-spent-coffee-coffee-arabica-l-grounds
#10
Kenia Vázquez-Sánchez, Nuria Martinez-Saez, Miguel Rebollo-Hernanz, Maria Dolores Del Castillo, Marcela Gaytán-Martínez, Rocio Campos-Vega
Antioxidant dietary fiber extracted from spent coffee grounds (FSCG) was evaluated as a potential functional food ingredient when incorporated in a food model (biscuits), and digested in vitro under simulated human gastrointestinal conditions. FSCG added to biscuits increased its total dietary fiber, antioxidant capacity after in vitro digestion, bioaccessibility of phenolic compounds (gallic acid and catechin) and amino acids. Furthermore, advanced glycation end products (AGEs), involved in chronic diseases, decreased up to 6-folds in the biscuits containing FSCG when compared with the traditional biscuit...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29737246/role-of-ox-ldl-and-lox-1-in-atherogenesis
#11
Ajoe John Kattoor, Sri Harsha Kanuri, Jawahar L Mehta
Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells such as endothelial cells, macrophages, platelets, fibroblasts and smooth muscle cells through LOX-1. LOX-1 is a 50 kDa transmembrane glycoprotein that serves as receptor for ox-LDL, modified lipoproteins, activated platelets and advance glycation end-products. Ox-LDL through LOX-1, in endothelial cells, cause increase in leukocyte adhesion molecules, activates pathways of apoptosis, increase reactive oxygen species and cause endothelial dysfunction...
May 7, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29710864/hypoglycemic-effects-in-alloxan-induced-diabetic-rats-of-the-phenolic-extract-from-mongolian-oak-cups-enriched-in-ellagic-acid-kaempferol-and-their-derivatives
#12
Peipei Yin, Yu Wang, Lingguang Yang, Jinling Sui, Yujun Liu
Our previous reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent in vitro antioxidant capacities as well as inhibitory activities against α-glucosidase, α-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days...
April 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29702605/advanced-glycation-endproducts-are-increased-in-the-animal-model-of-multiple-sclerosis-but-cannot-be-reduced-by-pyridoxamine-treatment-or-glyoxalase-1-overexpression
#13
Suzan Wetzels, Kristiaan Wouters, Toshio Miyata, Jean L J M Scheijen, Jerome J A Hendriks, Casper G Schalkwijk, Tim Vanmierlo
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS). The immune response in MS patients leads to the infiltration of immune cells in the CNS and their subsequent activation. Immune cell activation induces a switch towards glycolysis. During glycolysis, the dicarbonyl product methylglyoxal (MGO) is produced. MGO is a glycating agent that can rapidly form advanced glycation endproducts (AGEs). In turn, AGEs are able to induce inflammatory responses. The glyoxalase system is the endogenous defense system of the body to reduce the burden of MGO thereby reducing AGE formation...
April 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29702284/glycyrrhizin-ameliorates-atopic-dermatitis-like-symptoms-through-inhibition-of-hmgb1
#14
Ying Wang, Yue Zhang, Ge Peng, Xiuping Han
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease prevalent worldwide. This study investigated the effects of glycyrrhizin, an extract of licorice root, on the well-established model of 2,4-dinitrochlorobenzene-induced AD-like symptoms in mice. The severity of dermatitis, histopathological changes, serum IgE levels, changes in expression of high-mobility group box 1 (HMGB1), the receptor for advanced glycation end products (RAGE), nuclear factor (NF)-κB and inflammatory cytokines were evaluated...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29702126/irbesartan-attenuates-advanced-glycation-end-products-mediated-damage-in-diabetes-associated-osteoporosis-through-the-ages-rage-pathway
#15
Yan-Zhen Cheng, Shuang-Li Yang, Ji-Yu Wang, Meng Ye, Xiao-Yun Zhuo, Li-Tao Wang, Hong Chen, Hua Zhang, Li Yang
AIMS: Diabetes-associated osteoporosis is mainly caused by the formation and accumulation of advanced glycation end products (AGEs). Angiotensin II type 1 receptor blocker (ARB) has anabolic bone effects on the physicochemical properties of the bone in diabetes. We hypothesized that ARB could inhibit AGEs-induced deleterious effects. MAIN METHODS: In this study, we chose seven-week-old Leprdb/Lepr+ (db/+) and Leprdb/Leprdb (db/db) mice. After 12 week intervention by irbesartan, the microarchitecture and mechanical strength of the bone of seven-week-old db/db mice were investigated systematically...
April 24, 2018: Life Sciences
https://www.readbyqxmd.com/read/29693146/high-glucose-promotes-tumor-cell-proliferation-and-migration-in-lung-adenocarcinoma-via-the-rage%C3%A2-noxs-pathway
#16
Yuan-Fan Liao, Sui Yin, Zi-Qi Chen, Fan Li, Bo Zhao
Over the past few decades, it has been demonstrated that hyperglycemia can promote lung carcinoma growth, potentially through significantly increased glucose metabolism; however, the underlying mechanism remains to be fully elucidated. In the present study, treatment with a high concentration of glucose (HG) significantly promoted the proliferation and migration of A549 cells. Receptor for advanced glycation end‑products (RAGE) has previously been demonstrated to be associated with diabetes mellitus and oxidative stress, and nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are considered to be initiating factors of oxidative stress...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29689468/uplc-ms-ms-quantitative-analysis-and-structural-fragmentation-study-of-five-parmotrema-lichens-from-the-eastern-ghats
#17
K Kumar, Bandi Siva, V U M Sarma, Satish Mohabe, A Madhusudana Reddy, Joel Boustie, Ashok K Tiwari, N Rama Rao, K Suresh Babu
Comparative phytochemical analysis of five lichen species [Parmotrema tinctorum (Delise ex Nyl.) Hale, P. andinum (Mull. Arg.) Hale, P. praesorediosum (Nyl.) Hale, P. grayanum (Hue) Hale, P. austrosinense (Zahlbr.) Hale] of Parmotrema genus were performed using two complementary UPLC-MS systems. The first system consists of high resolution UPLC-QToF-MS/MS spectrometer and the second system consisted of UPLC-MS/MS in Multiple Reaction Monitoring (MRM) mode for quantitative analysis of major constituents in the selected lichen species...
April 19, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29689356/effects-of-polysaccharides-from-inonotus-obliquus-and-its-chromium-iii-complex-on-advanced-glycation-end-products-formation-%C3%AE-amylase-%C3%AE-glucosidase-activity-and-h-2-o-2-induced-oxidative-damage-in-hepatic-l02-cells
#18
Cong Wang, Xudong Gao, Ramesh Kumar Santhanam, Zhongqin Chen, Yue Chen, Leilei Xu, Chunli Wang, Nicola Ferri, Haixia Chen
In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated. Their protective effects against H2 O2 -induced oxidative damages in hepatic L02 cells were also assessed. Results demonstrated that UIOPC and UIOPS exhibited remarkable DPPH scavenging activity, ferric reducing power and hemolysis inhibitory activity. UIOPC also showed significant inhibitory capacity on α-amylase and α-glucosidase than UIOPS (P < 0...
April 21, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29682805/protective-effects-of-sarsasapogenin-against-early-stage-of-diabetic-nephropathy-in-rats
#19
Yao-Wu Liu, Yun-Chao Hao, Ya-Jing Chen, Shen-Yuan Yin, Meng-Ya Zhang, Li Kong, Tao-Yun Wang
Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium...
April 23, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29678518/pattern-recognition-receptors-mediate-pro-inflammatory-effects-of-extracellular-mitochondrial-transcription-factor-a-tfam
#20
Stephanie M Schindler, Matthew G Frank, Jessica L Annis, Steven F Maier, Andis Klegeris
Neuroinflammation is a common pathogenic mechanism for a number of neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Microglia, the immune cells of the brain, contribute to the onset and progression of the neuroinflammation observed in these diseases. Microglia become activated and initiate an inflammatory response by interacting with a diverse set of molecules, including the group of endogenous proteins released upon cell damage, termed damage-associated molecular patterns (DAMPs)...
April 17, 2018: Molecular and Cellular Neurosciences
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