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Intracerebral hemorrhage

Andrew M Naidech, Jennifer Beaumont, Kathryn Muldoon, Eric M Liotta, Matthew B Maas, Matthew B Potts, Babak S Jahromi, David Cella, Shyam Prabhakaran, Jane L Holl
OBJECTIVES: Prophylactic levetiracetam is currently used in ~40% of patients with intracerebral hemorrhage, and the potential impact of levetircetam on health-related quality of life is unknown. We tested the hypothesis that prophylactic levetiracetam is independently associated with differences in cognitive function health-related quality of life. DESIGN: Patients with intracerebral hemorrhage were enrolled in a prospective cohort study. We performed mixed models for T-scores of health-related quality of life, referenced to the U...
June 19, 2018: Critical Care Medicine
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
Sandro Marini, William J Devan, Farid Radmanesh, Laura Miyares, Timothy Poterba, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Roberto Elosua, Elisa Cuadrado-Godia, Carolina Soriano, Jaume Roquer, Christina E Kourkoulis, Alison M Ayres, Kristin Schwab, David L Tirschwell, Magdy Selim, Devin L Brown, Scott L Silliman, Bradford B Worrall, James F Meschia, Chelsea S Kidwell, Joan Montaner, Israel Fernandez-Cadenas, Pilar Delgado, Steven M Greenberg, Arne Lindgren, Charles Matouk, Kevin N Sheth, Daniel Woo, Christopher D Anderson, Jonathan Rosand, Guido J Falcone
BACKGROUND AND PURPOSE: Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH. METHODS: We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
Amit K Kishore, Andy Vail, Adam R Jeans, Angel Chamorro, Mario Di Napoli, Lalit Kalra, Peter Langhorne, Christine Roffe, Willeke Westendorp, Paul J Nederkoorn, Javier Garau, Diederik van de Beek, Joan Montaner, Mark Woodhead, Andreas Meisel, Craig J Smith
BACKGROUND AND PURPOSE: Identifying the causal pathogens of pneumonia complicating stroke is challenging, and antibiotics used are often broad spectrum, without recourse to the microbiological cause. We aimed to review existing literature to identify organisms responsible for pneumonia complicating stroke, before developing a consensus-based approach to antibiotic treatment. METHODS: A systematic literature review of multiple electronic databases using predefined search criteria was undertaken, in accordance with Cochrane and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidance...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
Jinkwon Kim, Cheryl D Bushnell, Hye Sun Lee, Sang Won Han
Hypertension is the single most important risk factor for hemorrhagic stroke, a leading cause of mortality and disability worldwide. Adherence to antihypertensive medication is essential to achieving strict blood pressure control, but poor adherence is common in clinical practice. We evaluated adherence to antihypertensive medication in patients with acute hemorrhagic stroke and its effects on long-term outcome. This was a retrospective cohort study based on a nationwide health insurance claims database in South Korea...
June 18, 2018: Hypertension
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
Paul A Lapchak, Paul D Boitano, Geoffrey de Couto, Eduardo Marbán
Acute ischemic stroke is devastating to patients and their families because of few viable therapeutic options to promote recovery after reperfusion windows close. Recent breakthroughs in biotechnology have resulted in a reproducible patented process for the purification of extracellular vesicles (EVs) from human cardiosphere-derived cells (CDCs). Because CDC-EVs have many features potentially beneficial to treat acute ischemic stroke, CDC-EVs were evaluated in an established small-clot rabbit embolic stroke model, where clinically relevant end points were used to assess recovery in a more translational large animal model...
June 13, 2018: Experimental Neurology
Tingwang Guo, Peng Ren, Xiaofei Li, Tiantian Luo, Yuhua Gong, Shilei Hao, Bochu Wang
Mass effect induced by growing hematoma is one of the mechanisms by which intracerebral hemorrhage (ICH) may result in brain injuries. Our goal was to investigate the damage mechanism of hydrostatic pressure associated with mass effect and the cooperative effect of hydrostatic pressure plus hemoglobin on neural injuries. Loading hydrostatic pressure on neurons and injecting agarose gel in the right striatum of rats was performed to establish the in vitro and vivo ICH models, respectively. The elevated hydrostatic pressure associated with ICH suppressed neurons and neural tissues viability, and disturbed the axons and dendrites in vitro and vivo...
June 15, 2018: Scientific Reports
Johannes Goldberg, Christian Jaeggi, Daniel Schoeni, Pasquale Mordasini, Andreas Raabe, David Bervini
OBJECTIVE Cerebral cavernous malformations (CCMs) are frequently diagnosed vascular malformations of the brain. Although most CCMs are asymptomatic, some can be responsible for intracerebral hemorrhage or seizures. In selected cases, microsurgical resection is the preferred treatment option. Treatment with the unselective β-blocker propranolol has been presumed to stabilize and eventually lead to CCM size regression in a limited number of published case series; however, the underlying mechanism and evidence for this effect remain unclear...
June 15, 2018: Journal of Neurosurgery
Xiang-Ming Xu, Emma Vestesson, Lizz Paley, Anita Desikan, David Wonderling, Alex Hoffman, Charles DA Wolfe, Anthony G Rudd, Benjamin D Bray
Introduction: Stroke registries are used in many settings to measure stroke treatment and outcomes, but rarely include data on health economic outcomes. We aimed to extend the Sentinel Stroke National Audit Programme registry of England, Wales and Northern Ireland to derive and report patient-level estimates of the cost of stroke care. Methods: An individual patient simulation model was built to estimate health and social care costs at one and five years after stroke, and the cost-benefits of thrombolysis and early supported discharge...
March 2018: European stroke journal
Chika Okada, Hironori Imano, Kazumasa Yamagishi, Renzhe Cui, Mitsumasa Umesawa, Koutatsu Maruyama, Isao Muraki, Mina Hayama-Terada, Yuji Shimizu, Tomoko Sankai, Takeo Okada, Masahiko Kiyama, Akihiko Kitamura, Hiroyasu Iso
AIMS: The frequency of breakfast intake has been reported to be inversely associated with the risk of cardiovascular events; however, it is uncertain what the impact of the energy and nutrient intakes from breakfast are. We assessed the association between these intakes from breakfast and the risk of stroke prospectively. METHODS: In a baseline survey of four Japanese communities between 1981 and 1990, we enrolled 3 248 residents (1 662 men and 1 586 women) aged 40-59 years who were free from stroke and heart disease and who responded to the 24-hour dietary recall survey...
June 13, 2018: Journal of Atherosclerosis and Thrombosis
Paolo Costa, Mario Grassi, Licia Iacoviello, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Maria Luisa DeLodovici, Maria Sessa, Andrea Zini, Maurizio Paciaroni, Cristiano Azzini, Massimo Gamba, Massimo Del Sette, Antonella Toriello, Carlo Gandolfo, Domenico Marco Bonifati, Rossana Tassi, Anna Cavallini, Alberto Chiti, Rocco Salvatore Calabrò, Francesco Grillo, Paolo Bovi, Giampaolo Tomelleri, Augusto Di Castelnuovo, Marco Ritelli, Giancarlo Agnelli, Alessandro De Vito, Nicola Pugliese, Giuseppe Martini, Corrado Lodigiani, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Claudio Cornali, Giovanni de Gaetano, Marina Colombi, Alessandro Padovani, Alessandro Pezzini
OBJECTIVE: To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS: We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 years and older with a group of age- and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) between 2002 and 2014...
June 13, 2018: Neurology
Vasileios-Arsenios Lioutas, Sarah Marchina, Louis R Caplan, Magdy Selim, Joseph Tarsia, Luciana Catanese, Jonathan Edlow, Sandeep Kumar
BACKGROUND: Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation with subsequent mechanical ventilation (MV) for "airway protection" with the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, and adversely affect patient outcomes. The net benefit of intubation and MV in this patient cohort has not been systematically investigated...
June 13, 2018: Cerebrovascular Diseases
Weilin Xu, Liansheng Gao, Tao Li, Jingwei Zheng, Anwen Shao, Jianmin Zhang
Neuronal apoptosis plays key roles in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first reported the role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in alleviating secondary brain injury through anti-apoptosis in rat model of ICH. The recombinant human-MANF (rh-MANF) and selective Akt inhibitor MK2206 was administrated intracerebroventricularly 1 h after ICH. Brain water content, behavioral assessment, BBB (blood brain barrier) leakage was evaluated 24 h after the induction of ICH...
2018: Frontiers in Molecular Neuroscience
Genki Hayashi, Cassandre Labelle-Dumais, Douglas B Gould
Collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) form heterotrimers that constitute a major component of nearly all basement membranes. COL4A1 and COL4A2 mutations cause a multisystem disorder that includes variable cerebrovascular and skeletal muscle manifestations. The pathogenicity of COL4A1 and COL4A2 mutations is generally attributed to impaired secretion into basement membranes. Sodium 4-phenylbutyrate (4PBA) is an FDA-approved drug that promotes mutant heterotrimer secretion in vitro and in vivo Here, we use different 4PBA treatment paradigms to define therapeutic parameters for preventing cerebrovascular and muscular pathologies in Col4a1 mutant mice...
June 12, 2018: Disease Models & Mechanisms
Giulia S Porcari, Lauren A Beslow, Rebecca N Ichord, Daniel J Licht, Jonathan T Kleinman, Lori C Jordan
BACKGROUND AND PURPOSE: Intracerebral hemorrhage is a considerable source of morbidity and mortality. This 3-center study describes outcomes of pediatric intracerebral hemorrhage and identifies 2-year neurological outcome predictors. METHODS: Children 29 days to 18 years of age presenting with intracerebral hemorrhage from March 2007 to May 2015 were enrolled prospectively. Exclusion criteria included trauma; intracranial tumor; hemorrhagic transformation of arterial ischemic stroke or cerebral sinovenous thrombosis; isolated subdural, epidural, or subarachnoid hemorrhage; and abnormal baseline neurological function...
June 12, 2018: Stroke; a Journal of Cerebral Circulation
Yi-Chung Lee, Chin-Ping Chung, Nai-Chen Chao, Jong-Ling Fuh, Feng-Chi Chang, Bing-Wing Soong, Yi-Chu Liao
BACKGROUND AND PURPOSE: Homozygous and compound heterozygous mutations in the high temperature requirement serine peptidase A1 gene ( HTRA1 ) cause cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy. However, heterozygous HTRA1 mutations were recently identified to be associated with autosomal dominant cerebral small vessel disease (SVD). The present study aims at investigating the clinical features, frequency, and spectrum of HTRA1 mutations in a Taiwanese cohort with SVD...
June 12, 2018: Stroke; a Journal of Cerebral Circulation
Lisa Ruth-Sahd, Melissa Schneider
When a patient presents with stroke-type symptoms, the correct diagnosis is imperative to determine appropriate treatment. Cerebral amyloid angiopathy (CAA), a buildup of amyloid proteins on the brain artery walls, is a cause of intracerebral hemorrhage. Improved diagnostic criteria and enhanced neuroimaging have resulted in earlier detection of CAA, which will hopefully lead to better outcomes for these patients. More research is being conducted, and neuroscience nurses need to stay informed about this condition to be able to appropriately care for and educate their patients who are diagnosed with CAA...
June 12, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Jiaoying Jia, Mingming Zhang, Qi Li, Qian Zhou, Yugang Jiang
Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that have been associated with brain function and neurological disease, but the expression profiles of lncRNAs after intracerebral hemorrhage (ICH) remain to be elucidated. In this study, we determined the expression pattern of nuclear factor-k-gene binding (NF-kB) interacting lncRNA (NKILA) after ICH and examined its respective effects on the endoplasmic reticulum stress (ERS)/autophagy pathway, hippocampal neuron loss, and the NF-kB pathway after type VII collagenase-induced ICH in rats...
June 12, 2018: Journal of Cellular Physiology
Wolf-Dirk Niesen, Michael Rosenkranz, Cornelius Weiller
Introduction: Transcranial high-resolution ultrasonography reliably allows diagnosis and monitoring of intracerebral hemorrhage in adults. Sonographic monitoring of subdural hematoma (SDH) has not been evaluated in adults so far. This study investigates the reliability of transcranial gray-scale sonography (TGS) in monitoring acute and chronic SDH in adults. Methods: TGS was performed in 47 consecutive patients with either acute or chronic SDH confirmed by cerebral CT...
2018: Frontiers in Neurology
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