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Intracerebral hemorrhage

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https://www.readbyqxmd.com/read/29224744/low-versus-standard-dose-intravenous-tissue-type-plasminogen-activator-for-acute-ischemic-stroke-an-updated-meta-analysis
#1
Huihui Liu, Huaguang Zheng, Yongjun Cao, Yuesong Pan, David Wang, Runhua Zhang, Shoujiang You, Xinmiao Zhang, Shuya Li, Xu Tong, Chun-Feng Liu, Yilong Wang
BACKGROUND: We performed a meta-analysis to compare the efficacy and safety between low- and standard-dose intravenous (IV) tissue-type plasminogen activator (tPA) for acute ischemic stroke (AIS) patients within 4.5 hours of symptom onset. METHODS: We searched PubMed and EMBASE for relevant studies from inception to June1, 2017. Cohort or randomized controlled studies for AIS within 4.5 hours of symptom onset with comparison between low-dose and standard-dose tPA were included...
December 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29224743/clinical-study-of-intracranial-and-extracranial-atherosclerotic-stenosis-in-spontaneous-intracerebral-hemorrhage-patients
#2
Chun-Yang Zhang, Shi-Ren Huang, Si-Yang Wang, Lei Shen, Ben-Qiang Deng
BACKGROUND AND PURPOSE: Nowadays, researchers had begun to focus on the use of antiplatelet and statins in patients with spontaneous intracerebral hemorrhage (sICH), but atherosclerosis treatment remains uncertain in these patients. We aimed to investigate the incidence and characteristics of intracranial and extracranial atherosclerotic stenosis in these patients and analyze its related risk factors. METHODS: Intracranial and extracranial arteries of consecutive patients with sICH were studied retrospectively with computed tomography angiography of head and neck...
December 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29222114/blood-vitronectin-is-a-major-activator-of-lif-and-il-6-in-the-brain-through-integrin-fak-and-upar-signaling
#3
M P Keasey, C Jia, L F Pimentel, R S Sante, C Lovins, T Hagg
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. VTN (not fibrinogen, fibronectin, laminin-111, collagen-I) robustly increased LIF and IL-6 within 4 hr in C6-astroglioma cells, while VTN-/- mouse plasma was less effective than wildtype. LIF and IL-6 were induced by intracerebral injection of rhVTN in mice, but less by intracerebral hemorrhage in VTN-/- than wildtype littermates...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29221969/variability-in-gastrostomy-tube-placement-for-intracerebral-hemorrhage-patients-at-us-hospitals
#4
David Y Hwang, Benjamin P George, Adam G Kelly, Eric B Schneider, Kevin N Sheth, Robert G Holloway
OBJECTIVE: We sought to characterize the variability among US hospitals with regard to gastrostomy tube placement for inpatients with intracerebral hemorrhage (ICH). METHODS: Using the Nationwide Inpatient Sample, we examined variations in the annual rate of gastrostomy tube placement from 2002 to 2011 for ICH patients admitted to hospitals with 30 or more annual ICH admissions. We then directly compared, among these hospitals, their individual frequencies of gastrostomy tube placement for ICH patients over the same time period...
December 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221132/neuroprotection-of-botch-in-experimental-intracerebral-hemorrhage-in-rats
#5
Binbin Mei, Haiying Li, Juehua Zhu, Junjie Yang, Ziying Yang, Zunjia Wen, Xiang Li, Haitao Shen, Meifen Shen, Gang Chen
Notch1 maturation participates in apoptosis and inflammation following intracerebral hemorrhage (ICH). It has been reported that Botch bound to and blocked Notch1 maturation. Here we estimated the role of Botch in ICH-induced secondary brain injury and underlying mechanisms. Experimental ICH model was induced by autologous arterial blood injection in Sprague-Dawley rats, and cultured primary rat cortical neurons were exposed to oxyhemoglobin to mimic ICH in vitro. Specific small interfering RNAs and expression plasmids encoding wild type Botch and Botch with Glu115Ala mutation were exploited...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219759/does-the-obesity-paradox-predict-functional-outcome-in-intracerebral-hemorrhage
#6
Neha S Dangayach, Harpreet Singh Grewal, Gian Marco De Marchis, Roberta K Sefcik, Rachel Bruce, Aarti Chhatlani, E Sander Connolly, M Cristina Falo, Sachin Agarwal, Jan Claassen, J Michael Schmidt, Stephan A Mayer
OBJECTIVE Being overweight or mildly obese has been associated with a decreased risk of death or hospitalization in patients with cardiovascular disease. Similarly, overweight patients admitted to an intensive care unit (ICU) have improved survival up to 1 year after admission. These counterintuitive observations are examples of the "obesity paradox." Does the obesity paradox exist in patients with intracerebral hemorrhage (ICH)? In this study the authors examined whether there was an association between obesity and functional outcome in patients with ICH...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29217744/the-ct-swirl-sign-is-associated-with-hematoma-expansion-in-intracerebral-hemorrhage
#7
D Ng, L Churilov, P Mitchell, R Dowling, B Yan
BACKGROUND AND PURPOSE: Hematoma expansion is an independent determinant of poor clinical outcome in intracerebral hemorrhage. Although the "spot sign" predicts hematoma expansion, the identification requires CT angiography, which limits its general accessibility in some hospital settings. Noncontrast CT, without the need for CT angiography, may identify sites of active extravasation, termed the "swirl sign." We aimed to determine the association of the swirl sign with hematoma expansion...
December 7, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29217662/long-term-prognostic-implications-of-cerebral-microbleeds-in-chinese-patients-with-ischemic-stroke
#8
Kui Kai Lau, Yuen Kwun Wong, Kay Cheong Teo, Richard S K Chang, Man Yu Tse, Chu Peng Hoi, Chung Yan Chan, Oi Ling Chan, Ryan Hoi Kit Cheung, Edmund Ka Ming Wong, Joseph Shiu Kwong Kwan, Edward S Hui, Henry Ka Fung Mak
BACKGROUND: This study was performed to determine the clinical correlates and long-term prognostic implications of microbleed burden and location in Chinese patients with ischemic stroke. METHODS AND RESULTS: We recruited 1003 predominantly Chinese patients with ischemic stroke who received magnetic resonance imaging at the University of Hong Kong. We determined the clinical correlates of microbleeds and the long-term risks (3126 patient-years of follow-up) of recurrent ischemic stroke and intracerebral hemorrhage (ICH) by microbleed burden (0 versus 1, 2-4, and ≥5) and location, adjusting for age, sex, and vascular risk factors and stratified by antithrombotic use...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29216502/intraventricular-hemorrhage-related-to-avm-rupture-description-outcomes-and-impact-of-intraventricular-fibrinolysis
#9
Vianney Gilard, Thomas Metayer, Clement Gakuba, Olivier Langlois, François Proust, Evelyne Emery, Thomas Gaberel
OBJECTIVES: Arteriovenous malformation (AVM) rupture could lead to intraventricular hemorrhage (IVH), a particularly severe form of intracranial bleeding. The epidemiology, presentation, management and outcomes of IVH related to AVM rupture have not been clearly addressed yet. The aim of the present study was to investigate the characteristics of IVH related to AVM rupture, with particular attention paid to functional outcomes and to the impact of intraventricular fibrinolysis (IVF). PATIENTS AND METHODS: Between 2011 and 2015, all patients suffering from IVH admitted in two tertiary neurosurgical centers were included in a prospective register...
December 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29215368/numeracy-and-interpretation-of-prognostic-estimates-in-intracerebral-hemorrhage-among-surrogate-decision-makers-in-the-neurologic-icu
#10
Nikita Leiter, Melissa Motta, Robert M Reed, Temitope Adeyeye, Debra L Wiegand, Nirav G Shah, Avelino C Verceles, Giora Netzer
OBJECTIVE: Clinicians caring for patients with intracerebral hemorrhage must often discuss prognosis and goals of care with their patients' surrogate decision makers, and may make numeric estimates of likelihood of survival and functional independence, informed by validated prediction models. Surrogates' prognostic estimates are often discordant with physicians', suggesting that physicians' numeric statements may not be accurately interpreted. We sought to assess the relationship between numeracy and interpretation of prognostic estimates in intracerebral hemorrhage among surrogate decision makers...
December 5, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29215136/spontaneous-intracerebral-hemorrhage-as-presentation-of-atypical-central-neurocytoma-the-role-of-angiogenesis-through-the-characterization-of-tumor-endothelial-cells
#11
Giovanni Marfia, Elena Pirola, Stefania Elena Navone, Matteo Beretta, Laura Guarnaccia, Elena Trombetta, Andrea Franzini, Paolo Rampini, Rolando Campanella
A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs)...
December 7, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29212744/selective-nlrp3-pyrin-domain-containing-protein-3-inflammasome-inhibitor-reduces-brain-injury-after-intracerebral-hemorrhage
#12
Honglei Ren, Ying Kong, Zhijia Liu, Dongyun Zang, Xiaoxia Yang, Kristofer Wood, Minshu Li, Qiang Liu
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without effective treatment. As a key component of the innate immune system, the NOD-like receptor (NLR) family, NLRP3 (pyrin domain-containing protein 3) inflammasome, when activated after ICH, promotes neuroinflammation and brain edema. MCC950 is a potent, selective, small-molecule NLRP3 inhibitor that blocks NLRP3 activation at nanomolar concentrations. Here, we examined the effect of MCC950 on brain injury and inflammation in 2 models of ICH in mice...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212738/stroke-incidence-by-major-pathological-type-and-ischemic-subtypes-in-the-auckland-regional-community-stroke-studies-changes-between-2002-and-2011
#13
Rita V Krishnamurthi, Suzanne Barker-Collo, Varsha Parag, Priyakumari Parmar, Emma Witt, Amy Jones, Susan Mahon, Craig S Anderson, P Alan Barber, Valery L Feigin
BACKGROUND AND PURPOSE: Major pathological stroke types (ischemic stroke [IS], primary intracerebral hemorrhage [ICH], and subarachnoid hemorrhage) and IS subtypes, have differing risk factors, management, and prognosis. We report changes in major stroke types and IS subtypes incidence during 10 years using data from the ARCOS (Auckland Regional Community Stroke Study) III performed during 12 months in 2002 to 2003 and the fourth ARCOS study (ARCOS-IV) performed in 2011 to 2012. METHODS: ARCOS-III and ARCOS-IV were population-based registers of all new strokes in the greater Auckland region (population aged >15 years, 1 119 192)...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212462/pharmacological-targeting-of-secondary-brain-damage-following-ischemic-or-hemorrhagic-stroke-traumatic-brain-injury-and-bacterial-meningitis-a-systematic-review-and-meta-analysis
#14
Thomas Beez, Hans-Jakob Steiger, Nima Etminan
BACKGROUND: The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic brain injury (TBI) and bacterial meningitis is unclear. This meta-analysis studied the effect of SBD targeted treatment on clinical outcome across the pathological entities. METHODS: Randomized, controlled, double-blinded trials on aforementioned entities with 'death' as endpoint were identified...
December 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29212271/inhibition-of-astrocytic-activity-alleviates-sequela-in-acute-stages-of-intracerebral-hemorrhage
#15
Cheng-Di Chiu, Nai-Wei Yao, Jeng-Hung Guo, Chiung-Chyi Shen, Hsu-Tung Lee, You-Pen Chiu, Hui-Ru Ji, Xianxiu Chen, Chun-Chung Chen, Chen Chang
Neurological deterioration of intracerebral hemorrhage (ICH) mostly occurs within the first 24 hours. Together with the microglia/macrophages (MMΦ), astrocytes are important cell population responsible for many brain injuries but rarely being highlighted in acute stage of ICH. In present study, we induced rats ICH either by collagenase or autologous blood injection. Experimental groups were classified as vehicle or Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3) treatment group (n = 9, each group)...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203311/lateral-ventricular-volume-asymmetry-predicts-poor-outcome-after-spontaneous-intracerebral-hemorrhage
#16
Jigang Chen, Danfeng Zhang, Zhenxing Li, Yan Dong, Kaiwei Han, Junyu Wang, Lijun Hou
BACKGROUND: Midline shift (MLS) was a known predictor for prognosis after spontaneous intracerebral hemorrhage (ICH), while it's secondary to lateral ventricular compression. In this study, we investigated whether lateral ventricular volume (LVV) asymmetry caused by ventricular compression was associated with poor outcome of ICH independently. METHODS: We retrospectively studied clinical patients with spontaneous ICH from January 2010 to January 2017. LVV was calculated using Slicer software...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29202795/validation-of-an-algorithm-that-determines-stroke-diagnostic-code-accuracy-in-a-japanese-hospital-based-cancer-registry-using-electronic-medical-records
#17
Yasufumi Gon, Daijiro Kabata, Keichi Yamamoto, Ayumi Shintani, Kenichi Todo, Hideki Mochizuki, Manabu Sakaguchi
BACKGROUND: This study aimed to validate an algorithm that determines stroke diagnostic code accuracy, in a hospital-based cancer registry, using electronic medical records (EMRs) in Japan. METHODS: The subjects were 27,932 patients enrolled in the hospital-based cancer registry of Osaka University Hospital, between January 1, 2007 and December 31, 2015. The ICD-10 (international classification of diseases, 10th revision) diagnostic codes for stroke were extracted from the EMR database...
December 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29201854/traumatic-intracerebral-and-subarachnoid-hemorrhage-due-to-a-ruptured-pseudoaneurysm-of-middle-meningeal-artery-accompanied-by-a-medial-sphenoid-wing-dural-arteriovenous-fistula
#18
Jae Won Park, Jong Young Lee
Traumatic pseudoaneurysms of middle meningeal artery (MMA) and medial sphenoid wing dural arteriovenous fistula (dAVF) are rare. These lesions usually result from traumatic brain injury, and associated with skull fracture. In this paper, the authors report a case of a patient with a ruptured traumatic pseudoaneurysm of MMA and medial sphenoid wing dAVF presented with an intracerebral hemorrhage in the left temporal region and subarachnoid hemorrhage. These lesions were completely obliterated by endovascular treatment, and the patient was recovered without any neurologic deficit...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29201851/postoperative-subarachnoid-hemorrhage-and-multipunctate-intracerebral-hemorrhages-following-evacuation-of-bilateral-chronic-subdural-hematomas
#19
Won-Bae Seung, Ju Ho Jeong
Chronic subdural hematoma (CSDH) can be easily treated by burr hole surgery. However, several complications including intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and acute subdural hematoma are rare after evacuation of a CSDH. A 77-year-old man was admitted with right hemiparesis and dysarthria. A brain computed tomography (CT) scan revealed a bilateral CSDH with midline shifting toward the right side. The patient got the burr hole trephination with the catheters insertion in the both sides of parietal area under the local anesthesia...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29201850/remote-hemorrhage-after-burr-hole-drainage-of-chronic-subdural-hematoma
#20
Chang Hyeun Kim, Geun Sung Song, Young Ha Kim, Young Soo Kim, Soon Ki Sung, Dong Wuk Son, Sang Weon Lee
Chronic subdural hematoma (CSDH) and symptomatic subdural hygroma are common diseases that require neurosurgical management. Burr hole trephination is the most popular surgical treatment for CSDH and subdural hygroma because of a low recurrence rate and low morbidity compared with craniotomy with membranectomy, and twist-drill craniotomy. Many reports suggest that placing a catheter in the subdural space for drainage can further reduce the rate of recurrence; however, complications associated with this type of drainage include acute subdural hematoma, cortical injury, and infection...
October 2017: Korean Journal of Neurotrauma
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