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Intracerebral hemorrhage

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https://www.readbyqxmd.com/read/29443444/diabetes-and-intracerebral-hemorrhage-baseline-characteristics-and-mortality
#1
Ron Liebkind, Daniel Gordin, Daniel Strbian, Atte Meretoja, Lena M Thorn, Stephanie Hägg-Holmberg, Carol Forsblom, Turgut Tatlisumak, Per-Henrik Groop, Jukka Putaala
BACKGROUND: Acknowledging the conflicting evidence of diabetes as a predictor of short- and long-term mortality following an intracerebral hemorrhage (ICH), we compared baseline characteristics and 30-day and long-term mortality between patients with and without diabetes after an ICH-paying special attention to differences between type 1 (T1D) and type 2 (T2D) diabetes. METHODS: Patients with a first-ever ICH were followed for a median of 2.3 years. Adjusting for demographics, comorbidities and documented ICH characteristics increasing mortality after ICH, logistic regression analysis assessed factors associated with case-fatality and 1-year survival among the 30-day survivors...
February 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29441841/efficacy-of-platelet-transfusion-for-acute-intracerebral-hemorrhage-among-patients-on-antiplatelet-therapy
#2
Onyinyechi Eke, Mercedeh Shanechi, Michael Gottlieb
Clinical question In patients taking antiplatelet therapy, does a platelet transfusion after acute spontaneous primary intracerebral hemorrhage reduce the risk of death or dependence? Article chosen Baharoglu MI, Cordonnier C, Al-Shahi Salman R, et al. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral hemorrhage associated with antiplatelet therapy (PATCH): a randomized, open-label, phase 3 trial. Lancet 2016;387(10038):2605-13. Study objective The primary objective of this study was to investigate whether a platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral hemorrhage associated with antiplatelet therapy use...
February 14, 2018: CJEM
https://www.readbyqxmd.com/read/29441487/prior-antiplatelet-therapy-is-not-associated-with-larger-hematoma-volume-or-hematoma-growth-in-intracerebral-hemorrhage
#3
Verena van Ginneken, Patricia Engel, Jochen B Fiebach, Heinrich J Audebert, Christian H Nolte, Andrea Rocco
Hematoma volume (HV) and hematoma growth (HG) predict mortality and poor outcome in intracerebral hemorrhage (ICH). While the influence of oral anticoagulation on HV, HG and outcome is well established, the effect of prior antiplatelet therapy (APT) remains uncertain. We retrospectively examined data from all patients with acute, primary ICH, and baseline head CT admitted to our department between January 2005 and February 2014. HV were calculated by ABC/2 method. HG was defined as present if HV increased between baseline and follow-up CT ≥ 30% or ≥ 6 mL...
February 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29440585/characteristics-of-randomized-trials-focusing-on-stroke-due-to-intracerebral-hemorrhage-systematic-review
#4
Arina Tamborska, Michael T C Poon, Rustam Al-Shahi Salman
BACKGROUND AND PURPOSE: The absence of treatments for intracerebral hemorrhage with significant consistent benefit in randomized controlled trials (RCTs) could be because of lack of treatment efficacy or the design of RCTs. METHODS: We searched the Cochrane Stroke Group Trials Register in December 2015 for completed and published RCTs reporting clinical outcome in adults with intracerebral hemorrhage. We collected data on publication year and language, study characteristics, and effect size...
February 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29439265/natural-history-of-vertebrobasilar-dolichoectatic-and-fusiform-aneurysms-a-systematic-review-and-meta-analysis
#5
Deena M Nasr, Kelly D Flemming, Giuseppe Lanzino, Harry J Cloft, David F Kallmes, Mohammad Hassan Murad, Waleed Brinjikji
BACKGROUND AND PURPOSE: Vertebrobasilar non-saccular and dolichoectatic aneurysms (VBDA) are a rare type of aneurysm and are generally associated with poor prognosis. In order to better characterize the natural history of VBDAs, we performed a systematic review and meta-analysis of the literature to determine rates of mortality, growth, rupture, ischemia, and intraparenchymal hemorrhage. MATERIALS AND METHODS: We searched the literature for longitudinal natural history studies of VBDA patients reporting clinical and imaging outcomes...
February 13, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29433151/anticoagulants-resumption-after-warfarin-related-intracerebral-haemorrhage-the-multicenter-study-on-cerebral-hemorrhage-in-italy-much-italy
#6
Loris Poli, Mario Grassi, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Maria Sessa, Andrea Zini, Maurizio Paciaroni, Cristiano Azzini, Massimo Gamba, Antonella Toriello, Rossana Tassi, Elisa Giorli, Rocco Salvatore Calabrò, Marco Ritelli, Alessandro De Vito, Nicola Pugliese, Giuseppe Martini, Alessia Lanari, Corrado Lodigiani, Marina Padroni, Valeria De Giuli, Filomena Caria, Andrea Morotti, Paolo Costa, Davide Strambo, Manuel Corato, Rosario Pascarella, Massimo Del Sette, Giovanni Malferrari, Marina Colombi, Alessandro Padovani, Alessandro Pezzini
Whether to resume antithrombotic treatment after oral anticoagulant-related intracerebral haemorrhage (OAC-ICH) is debatable. In this study, we aimed at investigating long-term outcome associated with OAC resumption after warfarin-related ICH, in comparison with secondary prevention strategies with platelet inhibitors or antithrombotic discontinuation. Participants were patients who sustained an incident ICH during warfarin treatment (2002-2014) included in the Multicenter Study on Cerebral Hemorrhage in Italy...
February 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29432410/angiopoietin-like-4-attenuates-brain-edema-and-neurological-deficits-in-a-mouse-model-of-experimental-intracerebral-hemorrhage
#7
Zhandong Qiu, Jia Yang, Gang Deng, Yu Fang, Dayong Li, Suming Zhang
BACKGROUND Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to evaluate the preventive effects of ANGPTL4 on the formation of brain edema and to determine whether it promotes the recovery of neurological function following intracerebral hemorrhage (ICH). MATERIAL AND METHODS Recombinant human ANGPTL4 (rhANGPTL4; 40 µg/kg) or a vehicle was administered intraperitoneally 5 min prior to bacterial collagenase-induced ICH in male C57/B6J mice...
February 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29432298/ventricular-assist-device-patients-have-different-clinical-outcomes-and-altered-patterns-of-bleeding-with-intracranial-hemorrhage
#8
Mustafa M Ahmed, Maryam Rahman, Dan Neal, Juan M Aranda, Charles T Klodell
Intracranial hemorrhage (ICH) is one of the most feared complications of left ventricular assist device (LVAD) support. However, outcomes in this group have not been well described. We therefore sought to examine clinical outcomes in this patient population in comparison to those with heart failure (HF) and no LVAD, as well as those without HF or LVAD. The National Inpatient Sample database, years 2002-2012, was queried to classify patients into 3 groups: any ICH (group 1), any HF with any ICH (group 2), and any LVAD with any ICH (group 3)...
February 9, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29429886/sex-differences-in-stroke-attack-incidence-and-mortality-rates-in-northern-france
#9
Aline Meirhaeghe, Dominique Cottel, Béatrice Cousin, Marie-Pierre Dumont, Nadine Marécaux, Philippe Amouyel, Jean Dallongeville
BACKGROUND: Age and sex have a major impact on stroke onset. AIMS: We aimed to compare the attack, incidence, and 28-day mortality rate for stroke as well as risk factors in men and women aged 35 and over. METHODS: Data were obtained between 2008 and 2015 from the stroke population-based registry covering the city of Lille (northern France). RESULTS: A total of 2426 strokes (1917 incident strokes) were recorded. The number of strokes was lower in women than in men when considering individuals under the age of 75 but was twice as high when considering individuals aged 75 or over...
February 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29428269/comparison-of-craniotomy-and-decompressive-craniectomy-in-large-supratentorial-intracerebral-hemorrhage
#10
Dong Bin Kim, Sang Kyu Park, Byeong Hoo Moon, Byeong Rae Cho, Dong Kyu Jang, Kyeong Sool Jang
Intracerebral hemorrhage (ICH) is devastating disease with high mortality and morbidity rates. Most ICH is evacuated by either craniotomy (CR) or decompressive craniectomy (DC) although optimal treatment has not been established yet. The objective of this study was to compare clinical outcomes of spontaneous ICH patients between CR and DC groups and determine clinical factors affecting clinical prognosis. We retrospectively analyzed our single-center experience with large supratentorial ICH. From January 2011 to December 2016, 286 consecutive supratentorial large ICH patients underwent surgery in our institute...
February 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29424646/optic-pathway-hypothalamic-glioma-hemorrhage-a-series-of-9-patients-and-review-of-the-literature
#11
Kirsten van Baarsen, Jonathan Roth, Natalia Serova, Roger J Packer, Ben Shofty, Ulrich-W Thomale, Giuseppe Cinalli, Helen Toledano, Shalom Michowiz, Shlomi Constantini
OBJECTIVE Hemorrhage (also known as apoplexy) in optic pathway gliomas (OPGs) is rare. Because of the variable presentations and low incidence of OPG hemorrhages, little is known about their clinical course and the best treatment options. The aim of this work was to review risk factors, clinical course, and treatment strategies of optic glioma hemorrhages in the largest possible number of cases. METHODS A total of 34 patients were analyzed. Nine new cases were collected, and 25 were identified in the literature...
February 9, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29424326/-risk-of-vitamin-k-antagonists-in-cases-of-cerebral-microbleeds
#12
B J H Verhaar, M W Vernooij, G J Biessels, M Muller
- Cerebral microbleeds are associated with a higher risk of intracerebral hemorrhage.- When microbleeds are detected, the possible underlying pathology should be considered; this includes cerebral amyloid angiopathy and other factors that increase the risk of haemorrhage, particularly hypertension. - No randomised trials have yet been conducted into haemorrhagic complications and cerebral infarctions in patients with microbleeds who take vitamin K antagonists. This means that it is not clear whether the intended prevention of cerebral infarctions outweighs the increased risk of haemorrhage associated with use of vitamin K antagonists by these patients...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29423148/multiple-lobar-intracerebral-hemorrhage-and-cerebral-amyloid-angiopathy-in-the-setting-of-apoe-%C3%B0-2-a-case-report-of-the-disease-course-and-call-for-improved-treatment-modalities
#13
Patrick Thornley, Stephan Oreskovich, John Provias, Jamie Silva, Kesava Reddy, Aleksa Cenic
We describe a case of multiple cerebral amyloid angiopathy-associated intracerebral hemorrhages (ICH) occurring at multi-focal lobar sites of the brain. A review and discussion of the current literature on the importance of Apolipoprotein E (ApoE) genotyping in prediction of ICH outcome and recurrence follows.
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29421803/portuguese-observational-study-of-ischaemic-stroke-in-patients-medicated-with-non-vitamin-k-antagonist-oral-anticoagulants
#14
José Beato-Coelho, João Pedro Marto, José Nuno Alves, Cláudia Marques-Matos, Sofia Calado, José Araújo, Luís Cunha, João Pinho, Elsa Azevedo, Miguel Viana-Baptista, João Sargento-Freitas
INTRODUCTION: Clinical trials and subsequent meta-analyses showed advantages of non-vitamin K antagonists oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation. The impact of preadmission anticoagulation in acute ischaemic stroke (AIS) has not been established. OBJECTIVE: To compare functional outcome of patients with AIS with preadmission NOACs vs. VKAs. METHODS: A retrospective analysis was conducted on consecutive AIS patients under oral anticoagulation (VKAs or NOACs) admitted in 4 Portuguese hospitals within a period of 30 months...
February 8, 2018: European Neurology
https://www.readbyqxmd.com/read/29421448/a-potential-new-risk-factor-for-stroke-streptococcus-mutans-with-collagen-binding-protein
#15
Chikanori Inenaga, Kazuya Hokamura, Kazuhiko Nakano, Ryota Nomura, Shuhei Naka, Toshihiko Ohashi, Takashi Ooshima, Nagato Kuriyama, Toshimitsu Hamasaki, Koichiro Wada, Kazuo Umemura, Tokutaro Tanaka
OBJECTIVE: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogen have a collagen-binding protein called Cnm and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample providing hospital, we report here the clinical details including intracranial aneurysms and ischemic stroke. METHODS: Under permission of our ethical committee, 429 samples of whole saliva were taken from patients who were admitted or visited our hospital from February 16, 2010 to February 28, 2011...
February 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29420958/lipids-lipoproteins-and-metabolites-and%C3%A2-risk-of-myocardial-infarction-and%C3%A2-stroke
#16
Michael V Holmes, Iona Y Millwood, Christiana Kartsonaki, Michael R Hill, Derrick A Bennett, Ruth Boxall, Yu Guo, Xin Xu, Zheng Bian, Ruying Hu, Robin G Walters, Junshi Chen, Mika Ala-Korpela, Sarah Parish, Robert J Clarke, Richard Peto, Rory Collins, Liming Li, Zhengming Chen
BACKGROUND: Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke subtypes. OBJECTIVES: This study sought to investigate the associations of plasma metabolic markers with risks of incident MI, ischemic stroke (IS), and intracerebral hemorrhage (ICH). METHODS: In a nested case-control study (912 MI, 1,146 IS, and 1,138 ICH cases, and 1,466 common control subjects) 30 to 79 years of age in China Kadoorie Biobank, nuclear magnetic resonance spectroscopy measured 225 metabolic markers in baseline plasma samples...
February 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29419694/akinetic-mutism-following-prefrontal-injury-by-an-electrical-grinder-a-case-report-a-diffusion-tensor-tractography-study
#17
Sung Ho Jang, Seong Ho Kim, Han Do Lee
RATIONALE: A 72-year-old male had suffered from head trauma resulting from injury to his frontal area by an electrical grinder while working at his home. PATIENT CONCERNS: He lost consciousness for approximately 10 minutes and experienced continuous post-traumatic amnesia. DIAGNOSES: He was diagnosed as traumatic intracerebral hemorrhage in both frontal lobes, intraventricular hemorrhage, and subarachnoid hemorrhage, and underwent decompressive craniectomy and hematoma removal...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416106/plasma-homocysteine-concentrations-and-risk-of-intracerebral-hemorrhage-a-systematic-review-and-meta-analysis
#18
Zhike Zhou, Yifan Liang, Huiling Qu, Mei Zhao, Feng Guo, Chuansheng Zhao, Weiyu Teng
Intracerebral hemorrhage (ICH) has the highest mortality rate in all strokes. However, controversy still exists concerning the association between plasma homocysteine (Hcy) and ICH. A systematic review and meta-analysis was conducted using Pubmed, Embase, and Web of Science up to April 18, 2017. Standard mean difference (SMD) for mean differences of plasma Hcy levels with 95% confidence intervals (CI) was calculated. Seven studies including 667 ICH patients and 1821 ischemic stroke patients were identified for meta-analysis...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29415814/application-of-the-four-score-in-intracerebral-hemorrhage-risk-analysis
#19
Sherri A Braksick, J Claude Hemphill, Jay Mandrekar, Eelco F M Wijdicks, Jennifer E Fugate
BACKGROUND: The Full Outline of Unresponsiveness (FOUR) Score is a validated scale describing the essentials of a coma examination, including motor response, eye opening and eye movements, brainstem reflexes, and respiratory pattern. We incorporated the FOUR Score into the existing ICH Score and evaluated its accuracy of risk assessment in spontaneous intracerebral hemorrhage (ICH). MATERIALS AND METHODS: Consecutive patients admitted to our institution from 2009 to 2012 with spontaneous ICH were reviewed...
February 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29410174/mortality-after-spontaneous-subarachnoid-hemorrhage-causality-and-validation-of-a-prediction-model
#20
Yasser B Abulhasan, Najayeb Alabdulraheem, Gabrielle Simoneau, Mark R Angle, Jeanne Teitelbaum
OBJECTIVE: To evaluate primary causes of death after spontaneous subarachnoid hemorrhage (SAH) and externally validate the HAIR score, a prognostication tool, in a single academic institution. METHODS: We reviewed all SAH patients admitted to our Neuro-ICU between 2010 and 2016. Univariate and multivariate logistic regressions were performed to identify predictors of in-hospital mortality. The HAIR score predictors were Hunt and Hess grade at treatment decision, age, intraventricular hemorrhage, and re-bleeding within 24 hours...
January 31, 2018: World Neurosurgery
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