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Intracerebral hemorrhage

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https://www.readbyqxmd.com/read/29042528/-a-case-of-ruptured-anterior-communicating-artery-aneurysm-with-visual-field-defects-and-deteriorating-to-severe-vision-loss
#1
Kazuki Sakakura, Go Ikeda, Yasunobu Nakai, Noriyuki Watanabe, Masanari Shiigai, Kazuya Uemura, Tetsuya Yamamoto, Akira Matsumura
Although Terson's syndrome is a well-known cause of vision loss due to intracerebral aneurysm rupture, optic nerve neuropathy can also occur because of other causes. Here, we report such a case, i.e., a ruptured anterior communicating artery aneurysm accompanied by vision loss and visual field disturbances due to a cause other than Terson's syndrome. A 47-year-old man presented with right superior altitudinal hemianopia. Computed tomography (CT) showed subarachnoid hemorrhage (SAH), and three-dimensional CT angiography revealed an anterior communicating artery aneurysm...
October 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29042193/microrna-126-3p-attenuates-blood-brain-barrier-disruption-cerebral-edema-and-neuronal-injury-following-intracerebral-hemorrhage-by-regulating-pik3r2-and-akt
#2
Tianyang Xi, Feng Jin, Ying Zhu, Jialu Wang, Ling Tang, Yanzhe Wang, David S Liebeskind, Zhiyi He
MiR-126, a microRNA implicated in blood vessel integrity, angiogenesis and vascular inflammation, is markedly decreased in the sera of patients with intracerebral hemorrhage (ICH). The current study aims to evaluate the potential therapeutic effect of miR-126-3p on brain injuries in a rat model of collagenase-induced ICH. Intracerebroventricular administration of a miR-126-3p mimic significantly alleviated behavioral defects 24 h after ICH, as examined by paw placement and corner tests. ICH led to increased blood-brain barrier (BBB) permeability and cerebral edema, both of which were attenuated by miR-126-3p mimic...
October 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29040110/racial-differences-in-palliative-care-use-after-stroke-in-majority-white-minority-serving-and-racially-integrated-u-s-hospitals
#3
Roland Faigle, Wendy C Ziai, Victor C Urrutia, Lisa A Cooper, Rebecca F Gottesman
OBJECTIVES: Racial/ethnic differences in palliative care resource use after stroke have been recognized, but it is unclear whether patient or hospital characteristics drive this disparity. We sought to determine whether palliative care use after intracerebral hemorrhage and ischemic stroke differs between hospitals serving varying proportions of minority patients. DESIGN: Population-based cross-sectional study. SETTING: Inpatient hospital admissions from the Nationwide Inpatient Sample between 2007 and 2011...
October 14, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29038137/author-response-ischemic-lesions-blood-pressure-dysregulation-and-poor-outcomes-in-intracerebral-hemorrhage
#4
Chelsea S Kidwell, Jonathan Rosand, Gina Norato, Simone Dixon, Bradford B Worrall, Michael L James, Mitchell S V Elkind, Matthew L Flaherty, Jennifer Osborne, Anastasia Vashkevich, Carl D Langefeld, Charles J Moomaw, Daniel Woo
No abstract text is available yet for this article.
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/29038136/letter-re-ischemic-lesions-blood-pressure-dysregulation-and-poor-outcomes-in-intracerebral-hemorrhage
#5
Simona Lattanzi, Mauro Silvestrini
No abstract text is available yet for this article.
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/29037792/spatial-temporal-expression-of-ndrg2-in-brain-tissues-in-a-rat-model-of-intracerebral-hemorrhage-a-pilot-study
#6
Linfeng Gao, Xiang Li, Haiying Li, Xiang Li, Jinquan Li, Haitao Shen, Gang Chen
N-myc downstream regulated gene 2 (NDRG2) was a member of the N-myc down regulated gene family which belongs to the alpha/beta hydrolase superfamily and played important roles in cell death. To date, the expression and effects of NDRG2 in brain after intracerebral hemorrhage (ICH) are unclear. In this study, we investigated the spatial-temporal expression of NDRG2 in brain tissues in a rat model of ICH. The expression levels of NDRG2 were tested in 3h, 6h, 12h, 24h, 48h, 72h, and 7d after ICH by western blot analysis...
October 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29037015/comparison-of-spot-sign-blend-sign-and-black-hole-sign-for-outcome-prediction-in-patients-with-intracerebral-hemorrhage
#7
Peter B Sporns, Michael Schwake, André Kemmling, Jens Minnerup, Wolfram Schwindt, Thomas Niederstadt, Rene Schmidt, Uta Hanning
BACKGROUND AND PURPOSE: Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. METHODS: In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29030969/adropin-preserves-the-blood-brain-barrier-through-a-notch1-hes1-pathway-after-intracerebral-hemorrhage-in-mice
#8
Lingyan Yu, Zhengyang Lu, Sherrefa Burchell, Derek Nowrangi, Anatol Manaenko, Xue Li, Yang Xu, Ningbo Xu, Jiping Tang, Haibin Dai, John H Zhang
Adropin is expressed in the central nervous system (CNS) and plays a crucial role in the development of stroke. However, little is currently known about the effects of adropin on the blood-brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of adropin in collagenase-induced ICH was investigated in mice. At 1-h post ICH, mice were administered with recombinant human adropin by intranasal. Brain water content, BBB permeability, and neurological function were measured at different time intervals...
October 14, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29030495/intracavitary-ultrasound-icarus-a-neuroendoscopic-adaptation-of-intravascular-ultrasound-for-intracerebral-hemorrhage-evacuation
#9
Alexander G Chartrain, Danny Hom, Joshua B Bederson, J Mocco, Christopher Paul Kellner
Neurosurgeons performing intracerebral hemorrhage evacuation procedures have limited options for monitoring hematoma evacuation and assessing residual hematoma burden intraoperatively. Here, we report the successful neuroendoscopic adaptation of intravascular ultrasound, referred to here as intracavitary ultrasound (ICARUS), in two patients. Pre-evacuation ICARUS demonstrated dense hematomas in both patients. Post-evacuation ICARUS in patient 1 demonstrated significant reduction in clot burden and two focal hyperechoic regions consistent with pockets of hematoma not previously seen with the endoscope or burr hole ultrasound...
October 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29030474/off-label-use-of-direct-oral-anticoagulants-in-intracerebral-hemorrhage-patients-with-prosthetic-valves
#10
Seemant Chaturvedi, Carlos A Molina, Magdy H Selim, Hans-Christoph Diener, Stefan H Hohnloser
No abstract text is available yet for this article.
October 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29028130/oral-anticoagulation-and-functional-outcome-after-intracerebral-hemorrhage
#11
Alessandro Biffi, Joji B Kuramatsu, Audrey Leasure, Hooman Kamel, Christina Kourkoulis, Kristin Schwab, Alison M Ayres, Jordan Elm, M Edip Gurol, Steven M Greenberg, Anand Viswanathan, Christopher D Anderson, Stefan Schwab, Jonathan Rosand, Fernando D Testai, Daniel Woo, Hagen B Huttner, Kevin N Sheth
OBJECTIVE: Oral Anticoagulation Treatment (OAT) resumption is a therapeutic dilemma in Intracerebral Hemorrhage (ICH) care, particularly for lobar hemorrhages related to amyloid angiopathy. We sought to determine whether OAT resumption after ICH is associated with long-term outcome, accounting for ICH location (i.e. lobar vs. non-lobar). METHODS: We meta-analyzed individual patient data from: 1) the multi-center RETRACE study (n=542); 2) a US-based single-center ICH study (n=261); 3) the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study (n=209)...
October 13, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29026928/-current-treatment-concepts-in-intracerebral-hemorrhage
#12
REVIEW
H B Huttner, J B Kuramatsu
BACKGROUND AND OBJECTIVE: In recent years, various important studies investigating the management of intracerebral hemorrhage (ICH) have been published. However, these have not entered guideline recommendations yet. Therefore, essential results are summarized here and the findings are integrated into current treatment concepts. MATERIALS AND METHODS: Based on a dedicated literature review and the authors' experience, up-to-date and high-quality investigations were identified...
October 12, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29026891/effect-of-emergency-medical-service-use-on-time-interval-from-symptom-onset-to-hospital-admission-for-definitive-care-among-patients-with-intracerebral-hemorrhage-a-multicenter-observational-study
#13
Dae Gon Kim, Yu Jin Kim, Sang Do Shin, Kyoung Jun Song, Eui Jung Lee, Yu Jin Lee, Ki Jeong Hong, Ju Ok Park, Young Sun Ro, Yoo Mi Park
OBJECTIVE: This study evaluated whether emergency medical service (EMS) use was associated with early arrival and admission for definitive care among intracerebral hemorrhage (ICH) patients. METHODS: Patients with ICH were enrolled from 29 hospitals between November 2007 and December 2012, excluding those patients with subarachnoid hemorrhage, traumatic ICH, and missing information. The patients were divided into four groups based on visit type to the definitive hospital emergency department (ED): direct visit by EMS (EMS-direct), direct visit without EMS (non-EMS-direct), transferred from a primary hospital by EMS (EMS-transfer), and transferred from a primary hospital without EMS (non-EMS-transfer)...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29023523/the-role-of-glutamate-in-neuronal-ion-homeostasis-a-case-study-of-spreading-depolarization
#14
Niklas Hübel, Mahshid S Hosseini-Zare, Jokūbas Žiburkus, Ghanim Ullah
Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on elucidating the molecular and cellular pathways involved in these mostly interdependent variations. In this paper, we develop the first computational framework that combines the Hodgkin-Huxley type spiking dynamics, dynamic ion concentrations and glutamate homeostasis, neuronal and astroglial volume changes, and ion exchange with vasculature into a comprehensive model to elucidate the role of glutamate uptake in the dynamics of spreading depolarization (SD)-the electrophysiological event underlying numerous pathologies including migraine, ischemic stroke, aneurysmal subarachnoid hemorrhage, intracerebral hematoma, and trauma...
October 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29023219/predictors-of-outcome-in-patients-with-pediatric-intracerebral-hemorrhage-development-and-validation-of-a-modified-score
#15
Alexis Guédon, Thomas Blauwblomme, Grégoire Boulouis, Camille Jousset, Philippe Meyer, Manoëlle Kossorotof, Marie Bourgeois, Stéphanie Puget, Michel Zerah, Catherine Oppenheim, Jean-François Meder, Nathalie Boddaert, Francis Brunelle, Christian Sainte-Rose, Olivier Naggara
Purpose To propose and validate a modified pediatric intracerebral hemorrhage (PICH) (mPICH) score and to compare its association with functional outcome to that of the original PICH score. Materials and Methods Data from prospectively included patients were retrospectively analyzed. Consecutive patients with nontraumatic PICH who had undergone clinical follow-up were included. The study population was divided into a development cohort (2008-2012, n = 100) and a validation cohort (2013-2016, n = 43). An mPICH score was developed after variables associated with poor outcome were identified at multivariate analysis (King's Outcome Scale for Childhood Head Injury score < 5a) in the development cohort...
October 12, 2017: Radiology
https://www.readbyqxmd.com/read/29021355/population-based-study-of-home-time-by-stroke-type-and-correlation-with-modified-rankin-score
#16
Amy Y X Yu, Edwin Rogers, Meng Wang, Tolulope T Sajobi, Shelagh B Coutts, Bijoy K Menon, Michael D Hill, Eric E Smith
OBJECTIVE: To describe home-time, stratified by stroke type, in a complete population and to determine its correlation with modified Rankin Scale (mRS) scores. METHODS: We used linked administrative data to derive home-time in all patients admitted for a cerebrovascular event in Alberta, Canada, between 2012 and 2016. Home-time is the number of days spent outside a health institution in the first 90 days after index hospitalization. We used negative binomial regression, adjusted for age, sex, Charlson comorbidity index, and hospital location, to determine the association between home-time and stroke type...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021311/acute-ischemic-stroke-with-tandem-lesions-technical-endovascular-management-and-clinical-outcomes-from-the-escape-trial
#17
Zarina Assis, Bijoy K Menon, Mayank Goyal, Andrew M Demchuk, Jai Shankar, Jeremy L Rempel, Daniel Roy, Alexander Y Poppe, Victor Yang, Cheemun Lum, Dar Dowlatshahi, John Thornton, Hana Choe, Paul A Burns, Donald F Frei, Blaise W Baxter, Michael D Hill
BACKGROUND: Tandem occlusions of the extracranial carotid and intracranial carotid or middle cerebral artery have a particularly poor prognosis without treatment. Several management strategies have been used with no clear consensus recommendations. We examined subjects with tandem occlusions enrolled in the ESCAPE trial and their outcomes. METHODS: Data are from the ESCAPE trial. Additional data were sought on interventions for each subject. RESULTS: There were 54 (17%) subjects with tandem extracranial and intracranial occlusions...
October 11, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29018128/island-sign-an-imaging-predictor-for-early-hematoma-expansion-and-poor-outcome-in-patients-with-intracerebral-hemorrhage
#18
Qi Li, Qing-Jun Liu, Wen-Song Yang, Xing-Chen Wang, Li-Bo Zhao, Xin Xiong, Rui Li, Du Cao, Dan Zhu, Xiao Wei, Peng Xie
BACKGROUND AND PURPOSE: The aim of the study was to investigate the usefulness of the computed tomography (CT) island sign for predicting early hematoma growth and poor functional outcome. METHODS: We included patients with spontaneous intracerebral hemorrhage (ICH) who had undergone baseline CT within 6 hours after ICH symptom onset in our hospital between July 2011 and September 2016. Two readers independently assessed the presence of the island sign on the admission noncontrast CT scan...
October 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29018127/bosutinib-attenuates-inflammation-via-inhibiting-salt-inducible-kinases-in-experimental-model-of-intracerebral-hemorrhage-on-mice
#19
Li Ma, Anatol Manaenko, Yi-Bo Ou, An-Wen Shao, Shu-Xu Yang, John H Zhang
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. Pronounced inflammation plays a significant role in the development of the secondary brain injury after ICH. Recently, SIK-2 (salt-inducible kinase-2) was identified as an important component controlling inflammatory response. Here we sought to investigate the role of SIK-2 in post-ICH inflammation and potential protective effects of SIK-2 inhibition after ICH. METHODS: Two hundred and ninety-three male CD-1 mice were used...
October 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28993004/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-for-a-specific-neuropsychological-pattern
#20
REVIEW
M Planton, N Raposo, J-F Albucher, J Pariente
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years...
October 6, 2017: Revue Neurologique
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