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https://www.readbyqxmd.com/read/27903537/comprehensive-cardiovascular-magnetic-resonance-assessment-in-patients-with-sarcoidosis-and-preserved-left-ventricular-ejection-fraction
#1
Simon Greulich, Daniel Kitterer, Joerg Latus, Eissa Aguor, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Agnes Mayr, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Cardiac sarcoidosis (CS) may manifest as arrhythmia or even sudden cardiac death. Because patients with CS often present with nonspecific symptoms, normal electrocardiography, and preserved left ventricular ejection fraction, a reliable diagnostic tool for the work-up of CS is needed. Late gadolinium enhancement-cardiovascular magnetic resonance has proven diagnostic value in CS but has some limitations that may be overcome by adding newer cardiovascular magnetic resonance mapping techniques...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27888183/long-term-visual-and-systemic-prognoses-of-83-cases-of-biopsy-proven-sarcoid-uveitis
#2
Cédric Rochepeau, Yvan Jamilloux, Sebastien Kerever, Camille Febvay, Laurent Perard, Christiane Broussolle, Carole Burillon, Laurent Kodjikian, Pascal Seve
AIMS: To determine the long-term visual and systemic outcomes of uveitis patients with biopsy-proven sarcoidosis. METHODS: A retrospective study of biopsy-proven sarcoid uveitis, with a 3-year minimum follow-up, seen at Lyon University Hospital, between April 2004 and January 2016. RESULTS: A total of 83 patients were included, with a median age at onset of 52 (37-62) years and an unbalanced gender ratio (women 77.1%). Thirty-one patients had original systemic sarcoidosis in addition to ocular localisation, whereas 52 initially presented with isolated sarcoid uveitis...
November 25, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27885956/solitary-tentorial-sarcoid-granuloma-associated-with-propionibacterium-acnes-infection-case-report
#3
Jiro Akimoto, Kenta Nagai, Daisuke Ogasawara, Yujiro Tanaka, Hitoshi Izawa, Michihiro Kohno, Keisuke Uchida, Yoshinobu Eishi
Sarcoidosis is a systemic granulomatous disease with unknown cause, which very rarely occurs exclusively in the central nervous system. The authors performed biopsy sampling of a mass that developed in the left tentorium cerebelli that appeared to be a malignant tumor. The mass was diagnosed as a sarcoid granuloma, which was confirmed with the onset of antibody reaction product against Propionibacterium acnes. Findings suggesting sarcoidosis to be an immune response to P. acnes infection have recently been reported, and they give insight for diagnosis and treatment of this disease...
November 25, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27804947/-necrotizing-sarcoid-granulomatosis
#4
L A Semenova, S G Radenska-Lopovok, S A Burtseva, Yu S Berezovsky, L N Lepekha
Necrotizing sarcoid granulomatosis (NSG) belongs to productive small-vessel vasculitis with the formation of sarcoid-like granulomas, which is accompanied by ischemic necrosis of varying degrees and duration. The disease involves the lung only. The clinical symptoms of the disease are nonspecific so the latter is detected rather rarely. The main diagnostic technique is morphological examination. Immune complex inflammation develops in the vessel walls with the formation of macrophage-histiocytic granulomas that do not contain epithelioid cells...
2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27779365/transcriptome-analysis-of-equine-sarcoids
#5
E Semik, A Gurgul, T Ząbek, K Ropka-Molik, C Koch, K Mählmann, M Bugno-Poniewierska
Equine sarcoids are the most commonly detected skin tumours in Equidae. In the present research, a comparative transcriptomic analysis was performed which aimed at looking inside a tumour biology and identification of the expression profile as a potential source of cancer specific genes useful as biomarkers. We have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour-distant skin samples. In total, 901 significantly differentially expressed genes (DEGs) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27761762/sarcoid-like-reaction-in-a-patient-with-uveitis-and-underlying-cancer
#6
Isabel Pascual-Camps, Nieves Alonso-Orcajo, Juan Pablo de la Fuente, Taygan Yilmaz, Miguel Cordero-Coma
PURPOSE: Sarcoidosis is a granulomatous disease of unknown etiology. Occasionally, triggering causes are identified, such as neoplasms, and they are termed sarcoid-like reactions, which may appear in any sarcoidotic target tissue. Choroidal metastases appear as part of widespread metastatic disease or as the first suggestion of neoplastic disease. They can also be a part of the differential diagnosis of a spectrum of inflammatory eye diseases. We present a case in which a lung carcinoma, pulmonary and eye sarcoid-like reactions, and choroidal metastasis take place in the same patient...
October 19, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27759709/choroidal-sarcoid-granuloma-simulating-prostate-carcinoma-metastasis
#7
Elif B Turkoglu, Sara E Lally, Carol L Shields
PURPOSE: To report a case of choroidal sarcoid granuloma simulating choroidal metastasis in a patient with prostate carcinoma. METHOD: Case report. RESULTS: A 66-year-old man was found to have an asymptomatic choroidal mass in his left eye. He had known history of pulmonary sarcoidosis without systemic involvement and prostate carcinoma without metastasis. On examination, visual acuity was 20/20 in each eye. Anterior segment was normal, without inflammatory sign in either eye...
October 18, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27759000/transcriptional-blood-signatures-of-sarcoidosis-sarcoid-like-reactions-and-tubercolosis-and-their-diagnostic-implications
#8
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Marco Tana, Claudio Tana
N/A.
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27758998/subacute-sarcoid-myositis-with-ocular-muscle-involvement-a-case-report-and-review-of-the-literature
#9
Y Hayashi, Yoshiki Ishii, J Nagasawa, S Arai, H Okada, F Ohmi, T Umetsu, Y Machida, K Kurasawa, A Takemasa, S Suzuki, T Senoh, T Sada, K Hirata
Sarcoidosis is a chronic granulomatous disease that can affect multiple organs. The lungs, eyes, and skin are known to be highly affected organs in sarcoidosis. There have been reports based on random muscle biopsy that 32-80% of systemic sarcoidosis comprises noncaseating granulomas; however, muscle involvement in sarcoidosis is generally asymptomatic and has an unknown frequency. We describe a case of acute to subacute sarcoid myositis of the skeletal and extraocular muscles. Typical ophthalmic involvement (manifested by infiltration of the ocular adnexa, intraocular inflammation, or infiltration of the retrobulbar visual pathways) and extraocular sarcoid myositis (as with the present case) is infrequently reported...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27758995/pulmonary-stenting-for-the-treatment-of-sarcoid-induced-pulmonary-vascular-stenosis
#10
Jose F Condado, Vasilis Babaliaros, Travis S Henry, Brian Kaebnick, Dennis Kim, Gerald W Staton
BACKGROUND: The best treatment of patients with external pulmonary vascular compression due to advanced sarcoidosis is unknown. OBJECTIVES: To report a single-center experience of percutaneous treatment for pulmonary vascular stenosis caused by external compression due to advanced sarcoidosis. METHODS: We report a case series of 5 patients with biopsy confirmed advanced sarcoidosis, seen at our academic institution with worsening dyspnea despite increase of immunosuppressive therapy...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27758950/electrochemotherapy-as-a-single-or-adjuvant-treatment-to-surgery-of-cutaneous-sarcoid-tumours-in-horses-a-31-case-retrospective-study
#11
N Tozon, P Kramaric, V Kos Kadunc, G Sersa, M Cemazar
The aim of our study was to evaluate the efficacy of electrochemotherapy (ECT) with cisplatin as a single or adjuvant treatment for sarcoids in equids. Different treatment options with different success rates were proposed. Thirty-one horses and one donkey with different clinical type, size and location of tumours were treated with ECT as a single treatment (18 animals with 52 tumour nodules) or as adjuvant treatment with marginal surgical excision (14 animals with 18 tumour nodules). In animals treated only with ECT with cisplatin, complete response was obtained in 48/52 (92...
October 7, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27757950/sarcoid-reaction-in-the-spleen-after-sigmoid-colon-cancer-resection-a-case-report
#12
Takafumi Shima, Yoshinori Tanaka, Kunihiro Katsuragi, Nagahisa Fujio, Shuichi Nakatani, Yasutsugu Kobayashi, Tadayuki Hida
BACKGROUND: A sarcoid reaction is a phenomenon characterized by histologically proven granulomatous lesions without evidence of sarcoidosis. This pathology is a benign tumor itself, but several reports have described sarcoid reactions accompanying malignant tumors. Sarcoid reactions occur in various cancers, such as skin, lung, ovary, stomach, and breast cancers. However, only a few published reports have described sarcoid reactions in patients with colorectal cancer. CASE PRESENTATION: A 76-year-old woman underwent laparoscopic sigmoidectomy for sigmoid colon cancer...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27755127/mechanism-of-granuloma-formation-in-sarcoidosis
#13
Priya Sakthivel, Dunja Bruder
PURPOSE OF REVIEW: The formation of noncaseating granuloma is a hallmark of pulmonary sarcoidosis. This review summarizes recent progress made to explain the cellular dynamics within the granuloma structure that may considerably differ between the two clinically distinct variants, that is, acute and chronic sarcoidosis. RECENT FINDINGS: Compelling evidence exists that in acute but not chronic sarcoidosis CD4 T lymphocytes specifically recognizing the auto-antigen vimentin on human leukocyte antigen-DR3 molecules accumulate in sarcoid granuloma...
January 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/27731528/characteristics-of-sarcoidosis-in-maori-and-pacific-islanders
#14
Margaret L Wilsher, Lisa M Young, Raewyn Hopkins, Megan Cornere
BACKGROUND AND OBJECTIVE: Ethnicity is strongly associated with variable clinical presentation in sarcoidosis but the association between ethnicity and clinical characteristics has not previously been described in patients of Polynesian ancestry, Maori and Pacific Islander (PI). The objective of this study was to describe the clinical characteristics of sarcoidosis in Maori and PI patients and determine if those were different to European patients. METHODS: A retrospective review of the medical records of 406 patients (69 Maori/PI) attending a specialist interstitial lung disease (ILD) clinic...
October 12, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27721933/intra-cardiac-distribution-of-late-gadolinium-enhancement-in-cardiac-sarcoidosis-and-dilated-cardiomyopathy
#15
Makoto Sano, Hiroshi Satoh, Kenichiro Suwa, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hideharu Hayashi, Takeji Saitoh
Cardiac involvement of sarcoid lesions is diagnosed by myocardial biopsy which is frequently false-negative, and patients with cardiac sarcoidosis (CS) who have impaired left ventricular (LV) systolic function are sometimes diagnosed with dilated cardiomyopathy (DCM). Late gadolinium enhancement (LE) in magnetic resonance imaging is now a critical finding in diagnosing CS, and the novel Japanese guideline considers myocardial LE to be a major criterion of CS. This article describes the value of LE in patients with CS who have impaired LV systolic function, particularly the diagnostic and clinical significance of LE distribution in comparison with DCM...
September 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27717976/coexisting-sarcoidal-granulomatous-inflammation-and-diffuse-tenosynovial-giant-cell-tumor-of-the-knee-after-a-total-knee-replacement-a-case-report
#16
Yaxia Zhang, Michael Joyce, Jean Schils, Thomas W Bauer
Sarcoidosis is a systemic inflammatory disorder characterized by non-caseating granulomas, predominantly involving lung, mediastinal lymph nodes and other organs. Synovium involvement is infrequent, and as far as we know, involvement of a periprosthetic membrane has not been reported in the English literature. Intra-articular diffuse tenosynovial giant cell tumor ("conventional diffuse pigmented villonodular synovitis") is an uncommon, locally aggressive neoplasm with few previous case reports in which it arose in periprosthetic tissues after knee arthroplasty...
October 7, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27698162/neoplasia-in-125-donkeys-equus-asinus-literature-review-and-a-survey-of-five-veterinary-schools-in-the-united-states-and-canada
#17
Corrine R Davis, Beth A Valentine, Emma Gordon, Sean P McDonough, Paula A Schaffer, Andrew L Allen, Patricia Pesavento
A diagnosis of neoplasia was noted in 125 of 357 donkeys (35%) in our review of medical records from 5 veterinary schools in the United States and Canada. Equine sarcoid was the most common tumor in our study, accounting for 72% of all tumors and 82% of cutaneous tumors. Soft-tissue sarcomas were the second most common skin tumors. All other types of neoplasia were rare. Important differences in the occurrence of neoplasia in donkeys compared to horses included the rarity or absence of squamous cell carcinoma in any organ system and gray horse melanoma...
November 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27687935/immune-response-to-bovine-papillomavirus-type-1-in-equine-sarcoid
#18
EDITORIAL
Sabine Brandt
No abstract text is available yet for this article.
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27687925/quantitative-analysis-of-infiltrating-immune-cells-and-bovine-papillomavirus-type-1-e2-positive-cells-in-equine-sarcoids
#19
H Geisshüsler, E Marti, M H Stoffel, K Kühni, A Stojiljkovic, C von Tscharner, B Vidondo, V Gerber, C Koch
Sarcoids are the most frequently observed skin tumours in equids and consist of cutaneous accumulations of transformed fibroblasts. Their aetiopathogenesis is closely linked to a presumably abortive infection by bovine papillomavirus (BPV) types 1 and 2. In cattle, dermal fibropapillomas induced by BPV1/2 usually regress spontaneously due to a local, cell-mediated, immune response; however, equids appear to lack an effective immune response to BPV1/2 and mechanisms of immune evasion have been postulated. As a consequence, equine sarcoids tend to persist and are prone to recur...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27646525/significance-of-coexistent-granulomatous-inflammation-and-lung-cancer
#20
Rucha S Dagaonkar, Caroline V Choong, Atasha Binti Asmat, Dokeu Basheer A Ahmed, Akhil Chopra, Albert Y H Lim, Dessmon Y H Tai, Ai Ching Kor, Soon Keng Goh, John Abisheganaden, Akash Verma
AIMS: Coexistence of lung cancer and granulomatous inflammation in the same patient confuses clinicians. We aimed to document the prevalence, clinicopathological features, treatment outcomes and prognosis in patients with coexisting granulomatous inflammation undergoing curative lung resection for lung cancer, in a tuberculosis (TB)-endemic country. METHODS: An observational cohort study of patients with lung cancer undergoing curative resection between 2012 and 2015 in a tertiary centre in Singapore...
September 19, 2016: Journal of Clinical Pathology
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