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https://www.readbyqxmd.com/read/29298523/current-development-in-novel-drug-delivery-systems-of-bioactive-molecule-plumbagin
#1
S Rajalakshmi, Niraj Vyawahare, Atmaram Pawar, Paresh Mahaparale, Bothiraja Chellampillai
Plumbagin (PLB), a member of the quinine family, mainly found in the plant Plumbago zeylanica Linn., potentially exhibit anticancer, anti-inflammatory, anti-oxidant, antifungal, neuroprotective, hypolipidemic and antibacterial activities. However, it has been well known that the application of PLB was limited owing to its water insolubility, instability and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages with the development of improved delivery platforms as the feasible approaches...
January 3, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29231058/efaverinz-and-nano-gold-loaded-mannosylated-niosomes-a-host-cell-targeted-topical-hiv-1-prophylaxis-via-thermogel-system
#2
Tanushree Malik, Gaurav Chauhan, Goutam Rath, Rohan N Kesarkar, Abhay S Chowdhary, Amit K Goyal
Sexual dissemination of Human Immunodeficiency Virus-1 (HIV-1) is the prime mode of its spread. Topical microbicidal approach has gained much attention, but no real success is observed till date, either due to toxicity or resistance of active moieties and the lack of efficient drug delivery approaches. In this research protocol, a unique combination approach of a standard drug moiety, that is, Efaverinz (EFV) and a nanometal, that is, gold nanoparticles (GNPs) was tried. Both these candidates were delivered through a mannosylated niosomal system, to exploit protein (lectins present on HIV host cells) - carbohydrate (oligosaccharides such as mannan present on HIV gp-120 receptor) interaction...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29219058/macrophage-targeted-cellular-carriers-for-effective-delivery-of-anti-tubercular-drugs
#3
S Beg, Jaya Agnihotri, Shibhna Singh, Mohammad Wais
Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB).Multi drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised. One third of the world's population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molecular mechanism of Mycobacterium tuberculosis, new targets receptors on alveolar macrophages must be explored out for eradication of TB from the globe...
December 7, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29210317/enhanced-ocular-bioavailability-of-fluconazole-from-niosomal-gels-and-microemulsions-formulation-optimization-and-in-vitro-in-vivo-evaluation
#4
Osama Abd El-Aazeem Soliman, Elham Abdel Monem Mohamed, Nabil Abdullah Ali Khatera
Fungal keratitis may cause vision loss if it is not treated. Methods other than ocular delivery exhibited several limitations. No previous studies investigated and compared ocular bioavailability of fluconazole (FLZ) from niosomal gels and microemulsions. Niosomal gels of FLZ (0.3% w/w) based on Span® 60 and cholesterol (CH) using 1% w/w carbopol® 934 (CP) were evaluated. FLZ microemulsions (0.3% w/v) containing isopropyl myristate (IPM, as oil phase) and a 3:1 mixture of Tween® 80 (as surfactant) and polyethylene glycol 400 (PEG 400, as cosurfactant) were characterized...
December 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29205060/correction-to-nematollahi-et%C3%A2-al-ternary-complex-of-plasmid-dna-with-nls-mu-mu-protein-and-cationic-niosome-for-biocompatible-and-efficient-gene-delivery-a-comparative-study-with-protamine-and-lipofectamine
#5
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29196152/nanotechnology-based-approaches-for-anti-diabetic-drugs-delivery
#6
REVIEW
Prashant Kesharwani, Bapi Gorain, Siew Yeng Low, Siew Ann Tan, Emily Chai Siaw Ling, Yin Khai Lim, Chuan Ming Chin, Pei Yee Lee, Chun Mey Lee, Chun Haw Ooi, Hira Choudhury, Manisha Pandey
Nanotechnology science has been diverged its application in several fields with the advantages to operate with nanometric range of objects. Emerging field of nanotechnology has been also being approached and applied in medical biology for improved efficacy and safety. Increased success in therapeutic field has focused several approaches in the treatment of the common metabolic disorder, diabetes. The development of nanocarriers for improved delivery of different oral hypoglycemic agents compared to conventional therapies includes nanoparticles (NPs), liposomes, dendrimer, niosomes and micelles, which produces great control over the increased blood glucose level and thus becoming an eye catching and most promising technology now-a-days...
November 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29186990/nanomedicine-approaches-for-sirolimus-delivery-a-review-of-pharmaceutical-properties-and-preclinical-studies
#7
Azadeh Haeri, Mahraz Osouli, Fereshteh Bayat, Sonia Alavi, Simin Dadashzadeh
Sirolimus (rapamycin) is a mammalian target of rapamycin (mTOR) inhibitor with immunosuppressive, antiproliferative, antiangiogenic, antifungal, anti-restenosis and anti-inflammatory properties. However, its clinical application is often hampered by poor aqueous solubility, first-pass metabolism, transport by p-glycoprotein efflux pump, limited oral bioavailability and nonspecific distribution in off-target sites. Recently, various formulation strategies have emerged to overcome these limitations. Among these, pharmaceutical nanotechnology with numerous advantages has great potential for sirolimus delivery...
November 29, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29173150/an-update-of-patents-preclinical-and-clinical-outcomes-of-lipid-nanoparticulate-systems
#8
Kamla Pathak, Ravi Shankar, Monika Joshi
BACKGROUND: Lipid nanoparticles have attracted increased degree of scientific and commercial attention in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems due to their various advantages over them and also due to overcoming the shortcomings of the already available colloidal systems like liposomes, niosomes and polymeric nanoparticles. DESCRIPTION: These have been investigated for delivery of macromolecules, genes, siRNA and other therapeutic agents for oral, topical, parenteral administration and target site specific delivery for various diseases like cancer, ocular diseases and brain disorders...
November 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29157978/stem-cell-based-gene-delivery-mediated-by-cationic-niosomes-for-bone-regeneration
#9
Noha Attia, Mohamed Mashal, Santiago Grijalvo, Ramon Eritja, Jon Zárate, Gustavo Puras, José Luis Pedraz
Bone morphogenetic protein-7(BMP-7) plays a pivotal role in the transformation of mesenchymal stem cells (MSCs) into bone. However, its impact is hampered due to its short half-life. Therefore, gene therapy may be an interesting approach to deliver BMP-7 gene to D1-MSCs. In this manuscript we prepared and characterized niosomes based on cationic lipid 2,3-di(tetradecyloxy)propan-1-amine, combined with polysorbate 80 for gene delivery purposes. Niosomes were characterized and combined initially with pCMS-EGFP reporter plasmid, and later with pUNO1-hBMP-7 plasmid to evaluate osteogenesis differentiation...
November 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29142430/topical-delivery-of-withania-somnifera-crude-extracts-in-niosomes-and-solid-lipid-nanoparticles
#10
Tawona N Chinembiri, Minja Gerber, Lissinda H du Plessis, Jan L du Preez, Josias H Hamman, Jeanetta du Plessis
Background: Withania somnifera is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma presents on the skin, it is prudent to probe the use of W. somnifera in topical formulations. To enhance topical drug delivery and to allow for controlled release, the use of niosomes and solid lipid nanoparticles (SLNs) as delivery vesicles were explored. Objective: The objective of this study is to determine the stability and topical delivery of W...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29130758/proniosomes-derived-niosomes-recent-advancements-in-drug-delivery-and-targeting
#11
Maryam Khatoon, Kifayat Ullah Shah, Fakhar Ud Din, Shefaat Ullah Shah, Asim Ur Rehman, Naz Dilawar, Ahmad Nawaz Khan
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology. Among them proniosomes become the superior over other vesicular carriers. Proniosomes are dry formulations of water soluble nonionic surfactant coated carrier system which immediately forms niosomes upon hydration. They have the capability to overcome the instability problems associated with niosomes and liposomes and have the potential to improve solubility, bioavailability, and absorption of various drugs. Furthermore, they offer versatile drug delivery concept for enormous number of hydrophilic and hydrophobic drugs...
2017: Drug Delivery
https://www.readbyqxmd.com/read/29081256/ternary-complex-of-plasmid-dna-with-nls-mu-mu-protein-and-cationic-niosome-for-biocompatible-and-efficient-gene-delivery-a-comparative-study-with-protamine-and-lipofectamine
#12
Mohammad Hadi Nematollahi, Masoud Torkzadeh-Mahanai, Abbas Pardakhty, Hossein Ali Ebrahimi Meimand, Gholamreza Asadikaram
Non-viral gene delivery methods are considered due to safety and simplicity in human gene therapy. Since the use of cationic peptide and niosome represent a promising approach for gene delivery purposes we used recombinant fusion protein and cationic niosome as a gene carrier. A multi-domain fusion protein including nuclear localization motif (NLS) and two DNA-binding (Mu) domains, namely NLS-Mu-Mu (NMM) has been designed, cloned and expressed in E. coli DE3 strain. Afterward, the interested protein was purified by affinity chromatography...
October 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29061106/potential-enhancement-and-targeting-strategies-of-polymeric-and-lipid-based-nanocarriers-in-dermal-drug-delivery
#13
Emine Kahraman, Sevgi Güngör, Yıldız Özsoy
Nanocarriers used for alternative drug-delivery strategies have gained interest due to improved penetration and delivery of drugs into specific regions of the skin in recent years. Dermal drug delivery via polymeric-based nanocarriers (polymeric nanoparticles, micelles, dendrimers) and lipid-based nanocarriers (solid-lipid nanoparticles and nanostructured lipid carriers, vesicular nanocarriers including liposomes, niosomes, transfersomes and ethosomes) has been widely investigated. Although penetration of nanocarriers through the intact skin could be restricted, these carriers are particularly considered as feasible for the treatment of dermatological diseases in which the skin barrier is disrupted and also for follicular delivery of drugs for management of skin disorders such as acne...
November 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28990537/nanomedicine-for-the-treatment-of-tuberculosis
#14
Zabih Ullah, Md Tanwir Athar, Abdus Samad
BACKGROUND: The diseases tuberculosis, triggered by intracellular pathogens, is a major problem for the global medical professionals. Treatments for these diseases through conventional dosage form consist of long-term therapy with multiple drugs leads to several side effects and contribute to low patient compliance and drug resistance. METHODS: The pathogens are fond to be situated in the intracellular compartments of the cells, which ultimately results in additional blockades to effective treatment...
October 6, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28990515/recent-advances-and-perspectives-in-liposomes-for-cutaneous-drug-delivery
#15
Amanda C Caritá, Josimar O Eloy, Marlus Chorilli, Robert J Lee, Gislaine Ricci Leonardi
The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28979296/dorzolamide-loaded-niosomal-vesicles-comparison-of-passive-and-remote-loading-methods
#16
Mohadeseh Hashemi Dehaghi, Azadeh Haeri, Hamid Keshvari, Zahra Abbasian, Simin Dadashzadeh
Glaucoma is a common progressive eye disorder and the treatment strategies will benefit from nanoparticulate delivery systems with high drug loading and sustained delivery of intraocular pressure lowering agents. Niosomes have been reported as a novel approach to improve drug low corneal penetration and bioavailability characteristics. Along with this, poor entrapment efficiency of hydrophilic drug in niosomal formulation remains as a major formulation challenge. Taking this perspective into consideration, dorzolamide niosomes were prepared employing two different loading methodologies (passive and remote loading methods) and the effects of various formulation variables (lipid to drug ratio, cholesterol percentage, drug concentration, freeze/thaw cycles, TPGS content, and external and internal buffer molarity and pH) on encapsulation efficiency were assessed...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28972460/tumor-regression-and-modulation-of-gene-expression-via-tumor-targeted-tocotrienol-niosomes
#17
Doryn Meam-Yee Tan, Ju-Yen Fu, Fu-Shun Wong, Hui-Meng Er, Yu-Sui Chen, Kalanithi Nesaretnam
AIM: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer. MATERIALS & METHODS: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy. RESULTS: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1...
October 2017: Nanomedicine
https://www.readbyqxmd.com/read/28956468/non-ionic-surfactant-based-vesicular-drug-delivery-system-for-topical-delivery-of-caffeine-for-treatment-of-cellulite-design-formulation-characterization-histological-anti-cellulite-activity-and-pharmacokinetic-evaluation
#18
Mahmoud H Teaima, Sally A Abdelhalim, Mohamed A El-Nabarawi, Dalia A Attia, Doaa A Helal
Cellulite is a common topographical alteration where skin acquires an orange peel or mattress appearance with alterations in adipose tissue and microcirculation. This work aims to develop and evaluate a topical niosomal gel formulae with good permeation to reach the subcutaneous fat layer. Several caffeine niosomal dispersions were prepared and incorporated into gel formulae using Carbopol 940 polymer, chemical penetration enhancers, and iontophoresis, then the prepared gels were applied onto the skin of rats and anticellulite activity of caffeine from the prepared gels compared to that of the commercial product Cellu Destock(®) was evaluated by histological study of the skin and measurement of plasma level of caffeine passing through the skin using liquid chromatography (LC/MS-MS)...
October 17, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28946803/anti-biofilm-activity-of-a-sophorolipid-amphotericin-b-niosomal-formulation-against-candida-albicans
#19
Farazul Haque, Mohammad Sajid, Swaranjit Singh Cameotra, Mani Shankar Battacharyya
Sophorolipids (SLs) have gained interest in the pharmaceutical industries due to their anti-microbial, anti-adhesive and anti-biofilm properties. In the present study, the production of SL was increased by using low-cost media components. The potential of a SL-based niosomal formulation of amphotericin B (AmB) was determined against biofilm of the opportunistic fungal pathogen Candida albicans. In-house prepared SL-AmB niosomes were characterized by different microscopic techniques. The mean entrapment efficiency of AmB within SL-AmB niosome was 63...
September 26, 2017: Biofouling
https://www.readbyqxmd.com/read/28874081/physicochemical-investigation-and-in-vivo-activity-of-anti-malarial-drugs-co-loaded-in-tween-80-niosomes
#20
Miloni Thakkar, Brijesh S
Drugs used for the treatment and prevention of malaria are often plagued by the problem of development of resistance. This has hampered their therapeutic efficiency and rendered them ineffective for monotherapy. However, if re-packaged and combined properly, many of these neglected anti-malarial drugs can possibly find their way back into the treatment regime. The present study evaluates the use of curcumin (CC) and primaquine (PRI) as an anti-malarial combination, packaged within niosomes, in comparison to their respective monotherapy options...
September 5, 2017: Journal of Liposome Research
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