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https://www.readbyqxmd.com/read/28078954/nanovesicle-delivery-to-the-liver-via-retinol-binding-protein-and-platelet-derived-growth-factor-receptors-how-targeting-ligands-affect-biodistribution
#1
Ching-Yun Hsu, Chun-Han Chen, Ibrahim A Aljuffali, You-Shan Dai, Jia-You Fang
AIM: Nanovesicles (NVs) conjugating ligands can deliver to the specific nidus. We designed a nanosystem targeting the injectable niosomes to liver for examining biodistribution. METHODOLOGY: Vitamin A and antiplatelet-derived growth factor receptor antibody were employed as the ligands to be taken by hepatic stellate cells. The biodistribution in rats was visualized by bioimaging. RESULTS: A significant liver accumulation was detected for antibody-embedded NVs at 2 h after dosing...
January 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28067087/oral-delivery-of-allopurinol-niosomes-in-treatment-of-gout-in-animal-model
#2
Neelu Singh, Poonam Parashar, Chandra Bhushan Tripathi, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
CONTEXT: Gout is a painful disorder which does not have an efficient delivery system for its treatment. OBJECTIVE: Development and in vitro, in vivo evaluation of allopurinol loaded nonionic surfactant based niosomes was envisaged. MATERIALS AND METHODS: Niosomes were prepared with Span 20 and Tween 20(1:1 molar ratio) using ether injection method. The formulations were screened for entrapment efficiency, particle size analysis, zeta potential, release kinetics, in vivo activity and stability studies...
January 8, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27979250/%C3%AE-tocopherol-loaded-niosome-prepared-by-heating-method-and-its-release-behavior
#3
Ladan Basiri, Ghadir Rajabzadeh, Aram Bostan
α-Tocopherol-loaded niosome was developed using modified heating method. The influence of surfactants (Span60 and Tween60) in different mole ratios, presence or absence of cholesterol (Chol) and dicetyl phosphate (DCP) as well as different concentration of α-tocopherol (α-TOC) on mean size, polydispersity index, zeta potential and entrapment efficiency (EE) was evaluated. The results showed that α-TOC loaded niosomes exhibited a small mean size (73.85±0.6-186±0.58nm), narrow size distribution and high EE (61...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27977311/flurbiprofen-loaded-niosomes-in-gel-system-improves-the-ocular-bioavailability-of-flurbiprofen-in-the-aqueous-humor
#4
El-Sayed Marwa M, Amal K Hussein, Hatem A Sarhan, Mansour Heba F
The present work aimed to prolong the contact time of flurbiprofen in the ocular tissue to improve the drug anti-inflammatory activity. Different niosome systems were fabricated adopting thin film hydration technique and using the non-ionic surfactant Span 60. The morphology of the prepared niosomes was characterized by scanning electron microscopy (SEM). Physical characterization by differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy were conducted for the optimized formula (F5) that was selected on the basis of percent entrapment efficiency, vesicular size and total lipid content...
December 15, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27956194/enhancement-of-8-methoxypsoralen-topical-delivery-via-nanosized-niosomal-vesicles-formulation-development-in-vitro-and-in-vivo-evaluation-of-skin-deposition
#5
Ahmed Alaa Kassem, Sameh Hosam Abd El-Alim, Marwa Hasanein Asfour
The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol at five different molar ratios. The obtained vesicles revealed high entrapment efficiencies (83.04-89.90%) with nanometric vesicle diameters (111.1-198.8nm) of monodisperse distribution (PDI=0.145-0.216), zeta potential values <-48...
December 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27933988/niosomes-consisting-of-tween-60-and-cholesterol-improve-the-chemical-stability-and-antioxidant-activity-of-epigallocatechin-gallate-under-intestinal-tract-conditions
#6
Rong Liang, Ling Chen, Wallace Yokoyama, Peter A Williams, Fang Zhong
In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF)...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27904075/in-vitro-permeation-and-skin-retention-of-%C3%AE-mangostin-proniosome
#7
Gan Siaw Chin, Hiroaki Todo, Wesam Radhi Kadhum, Mariani Abdul Hamid, Kenji Sugibayashi
The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27886514/sugar-based-novel-niosomal-nanocarrier-system-for-enhanced-oral-bioavailability-of-levofloxacin
#8
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali
CONTEXT: Vesicular systems have attracted great attention in drug delivery because of their amphiphilicity, biodegradability, non-toxicity and potential for increasing drug bioavailability. OBJECTIVE: A novel sugar-based double-tailed surfactant containing renewable block was synthesized for preparing niosomal vesicles that could be exploited for Levofloxacin encapsulation, aiming to increase its oral bioavailability. MATERIALS AND METHODS: The surfactant was characterized by (1)H NMR, mass spectroscopy and Fourier transform infrared spectroscopy (FT-IR)...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27863986/microfluidics-based-manufacture-of-liposomes-simultaneously-entrapping-hydrophilic-and-lipophilic-drugs
#9
Sameer Joshi, Maryam T Hussain, Carla B Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J Kirby, Yvonne Perrie
Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production methods for liposomes. Therefore, the aim of our research has been to consider the application of microfluidics in the manufacture of liposomes containing either or both a water soluble and a lipid soluble drug to promote co-delivery of drugs...
September 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863660/microfluidics-based-manufacture-of-liposomes-simultaneously-entrapping-hydrophilic-and-lipophilic-drugs
#10
Sameer Joshi, Maryam T Hussain, Carla B Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J Kirby, Yvonne Perrie
Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production methods for liposomes. Therefore, the aim of our research has been to consider the application of microfluidics in the manufacture of liposomes containing either or both a water soluble and a lipid soluble drug to promote co-delivery of drugs...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27855894/proniosomal-powders-of-natural-canthaxanthin-preparation-and-characterization
#11
Maryam Ravaghi, Chiara Sinico, Seyed Hadi Razavi, Seyed Mohammad Mousavi, Elena Pini, Anna Maria Fadda
In this study, canthaxanthin (CTX) was produced by Dietzia natronolimnaea HS-1 using beetroot molasses as substrate and used for encapsulation in proniosome powders after extraction, with the aim of improving its stability. Proniosome powders were prepared with an equimolar ratio of span 60/cholesterol and four different carriers, namely maltodextrin, mannitol, lactose and pullulan. The properties of these formulations as both proniosomal powders and resulted niosomal dispersions were evaluated. The type of carriers had significant effects on the micrometric properties of proniosome powders which were further confirmed by the results of SEM analysis...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27837536/environmental-scanning-electron-microscope-imaging-of-vesicle-systems
#12
Yvonne Perrie, Habib Ali, Daniel J Kirby, Afzal U R Mohammed, Sarah E McNeil, Anil Vangala
The structural characteristics of liposomes have been widely investigated and there is certainly a strong understanding of their morphological characteristics. Imaging of these systems, using techniques such as freeze-fracturing methods, transmission electron microscopy, and cryo-electron imaging, has allowed us to appreciate their bilayer structures and factors which can influence this. However, there are few methods which all us to study these systems in their natural hydrated state; commonly the liposomes are visualized after drying, staining, and/or fixation of the vesicles...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27822958/double-tailed-acyl-glycoside-niosomal-nanocarrier-for-enhanced-oral-bioavailability-of-cefixime
#13
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdul Sadiq, Imdad Ali, Farid Ahmed, Waqas Nawaz
Novel, safe, efficient, and cost effective surfactants from renewable resources has attracted attention for enhancing solubility and bioavailability of hydrophobic dugs. We report the synthesis, characterization, and biocompatibility of a novel non-ionic acyl glycoside double-tailed surfactant for niosomal drug delivery system. Structure of the surfactant was confirmed by (1)H NMR and mass spectroscopy. Applications of surfactant in niosomal drug delivery were explored using Cefixime as model. The shape, size, and polydispersity index (PDI) of drug loaded vesicles were investigated with atomic force microscope (AFM) and dynamic light scattering (DLS)...
November 8, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27766598/pharmaceutical-microscale-and-nanoscale-approaches-for-efficient-treatment-of-ocular-diseases
#14
I Bravo-Osuna, V Andrés-Guerrero, P Pastoriza Abal, I T Molina-Martínez, R Herrero-Vanrell
Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the development of novel drug delivery systems to be used for ocular therapy. The location of the target site in the eye as well as the ophthalmic disease will determine the route of administration (topical, intraocular, periocular, and suprachoroidal administration) and the most adequate device...
October 20, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27717916/fabrication-of-novel-ultradeformable-bilosomes-for-enhanced-ocular-delivery-of-terconazole-in-vitro-characterization-ex-vivo-permeation-and-in-vivo-safety-assessment
#15
Aly A Abdelbary, Wessam H Abd-Elsalam, Abdulaziz M Al-Mahallawi
The objective of this work was to encapsulate terconazole (TCZ), a water insoluble antifungal drug, into novel ultradeformable bilosomes (UBs) for achieving enhanced ocular delivery. In addition to the constituents of the conventional bilosomes; namely, Span 60, cholesterol, and the bile salts, UBs contain an edge activator which imparts extra elasticity to the vesicles and consequently hypothesized to result in improved corneal permeation. In this study, TCZ loaded UBs were prepared utilizing ethanol injection method according to 2(3) full factorial design...
November 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27651102/niosomes-as-nano-delivery-systems-in-the-pharmaceutical-field
#16
Cristal Cerqueira-Coutinho, Elisabete P Dos Santos, Claudia Regina E Mansur
Nanosystems used in the pharmaceutical field aim to guarantee a controlled release and efficacy boost with dose reduction of the drug. The same active ingredient could be vehiculated in different concentrations in distinct nanosystems. Among these nanostructures, the vesicular ones present a versatile delivery system that could be applied to encapsulate lipophilic, amphiphilic, and hydrophilic compounds. Liposomes are the most well-known vesicular nanosystems; however, there are others, such as niosomes, that are composed of nonionic surfactants that are polymeric or conventional...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27644625/preparation-characterization-and-cytotoxicity-of-silibinin-containing-nanoniosomes-in-t47d-human-breast-carcinoma-cells
#17
Boshra Amiri, Meysam Ebrahimi-Far, Zahra Saffari, Azim Akbarzadeh, Esmaeil Soleimani, Mohsen Chiani
BACKGROUND: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent active against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. OBJECTIVE: To prepare nanoniosomal silibinin and evaluate its cytotoxicity in the T-47D breast cancer cell line. MATERIALS AND METHODS: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27632682/single-intravenous-dose-of-novel-flurbiprofen-loaded-proniosome-formulations-provides-prolonged-systemic-exposure-and-anti-inflammatory-effect
#18
Preeti Verma, Sunil K Prajapati, Rajbharan Yadav, Danielle Senyschyn, Peter R Shea, Natalie L Trevaskis
Vesicular and colloidal delivery systems can be designed to control drug release spatially and temporally to improve drug efficacy and side effect profiles. Niosomes (vesicles prepared from nonionic surfactants in aqueous media) are gaining interest as an alternative vesicular delivery system as they offer advantages such as biocompatibility, chemical stability, low cost, high purity, and versatility. However, the physical stability of niosomes, like other vesicular systems, is limited by vesicle fusion, aggregation, and leakage...
November 7, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27620074/transdermal-delivery-from-liposomal-formulations-evolution-of-the-technology-over-the-last-three-decades
#19
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes(®), ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27612773/formulation-and-optimization-of-niosomes-for-topical-diacerein-delivery-using-3-factor-3-level-box-behnken-design-for-the-management-of-psoriasis
#20
Seyedeh Raziyeh Mahdavi Moghddam, Abdul Ahad, Mohd Aqil, Syed Sarim Imam, Yasmin Sultana
This research aimed towards the design of preparations of diacerein loaded cholesterol rich niosomes by employing a 3-factor, 3-level Box-Behnken design. Results indicated that Span 60 (90mg) and cholesterol (10mg), and 45min of hydration time were found to be optimum for niosomes preparation. The prepared cholesterol rich niosomes were uniform and spherical in size. Optimized formulation F2 entrapped the drug with 83.02% efficiency in the cholesterol rich niosomes of the size 477.8nm, presented the flux of 2...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
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