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I Bravo-Osuna, V Andrés-Guerrero, P Pastoriza Abal, I T Molina-Martínez, R Herrero-Vanrell
Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the development of novel drug delivery systems to be used for ocular therapy. The location of the target site in the eye as well as the ophthalmic disease will determine the route of administration (topical, intraocular, periocular, and suprachoroidal administration) and the most adequate device...
October 20, 2016: Drug Delivery and Translational Research
Aly A Abdelbary, Wessam H Abd-Elsalam, Abdulaziz M Al-Mahallawi
The objective of this work was to encapsulate terconazole (TCZ), a water insoluble antifungal drug, into novel ultradeformable bilosomes (UBs) for achieving enhanced ocular delivery. In addition to the constituents of the conventional bilosomes; namely, Span 60, cholesterol, and the bile salts, UBs contain an edge activator which imparts extra elasticity to the vesicles and consequently hypothesized to result in improved corneal permeation. In this study, TCZ loaded UBs were prepared utilizing ethanol injection method according to 2(3) full factorial design...
October 4, 2016: International Journal of Pharmaceutics
Cristal Cerqueira-Coutinho, Elisabete P Dos Santos, Claudia Regina E Mansur
Nanosystems used in the pharmaceutical field aim to guarantee a controlled release and efficacy boost with dose reduction of the drug. The same active ingredient could be vehiculated in different concentrations in distinct nanosystems. Among these nanostructures, the vesicular ones present a versatile delivery system that could be applied to encapsulate lipophilic, amphiphilic, and hydrophilic compounds. Liposomes are the most well-known vesicular nanosystems; however, there are others, such as niosomes, that are composed of nonionic surfactants that are polymeric or conventional...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
Boshra Amiri, Meysam Ebrahimi-Far, Zahra Saffari, Azim Akbarzadeh, Esmaeil Soleimani, Mohsen Chiani
BACKGROUND: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent active against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. OBJECTIVE: To prepare nanoniosomal silibinin and evaluate its cytotoxicity in the T-47D breast cancer cell line. MATERIALS AND METHODS: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Preeti Verma, Sunil Kumar Prajapati, Rajbharan Yadav, Danielle Senyschyn, Peter R Shea, Natalie L Trevaskis
Vesicular and colloidal delivery systems can be designed to control drug release spatially and temporally to improve drug efficacy and side effect profiles. Niosomes (vesicles prepared from nonionic surfactants in aqueous media) are gaining interest as an alternative vesicular delivery system as they offer advantages such as biocompatibility, chemical stability, low cost, high purity and versatility. However, the physical stability of niosomes, like other vesicular systems, is limited by vesicle fusion, aggregation and leakage...
September 15, 2016: Molecular Pharmaceutics
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes®, ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Seyedeh Raziyeh Mahdavi Moghddam, Abdul Ahad, Mohd Aqil, Syed Sarim Imam, Yasmin Sultana
This research aimed towards the design of preparations of diacerein loaded cholesterol rich niosomes by employing a 3-factor, 3-level Box-Behnken design. Results indicated that Span 60 (90mg) and cholesterol (10mg), and 45min of hydration time were found to be optimum for niosomes preparation. The prepared cholesterol rich niosomes were uniform and spherical in size. Optimized formulation F2 entrapped the drug with 83.02% efficiency in the cholesterol rich niosomes of the size 477.8nm, presented the flux of 2...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Muhammad Imran Khan, Asadullah Madni, Jouni Hirvonen, Leena Peltonen
In this study, the feasibility of ultrasonic processing (UP) technique as green preparation method for production of poorly soluble model drug substance, diacerein, loaded niosomes was demonstrated. Also, the effects of different surfactant systems on niosomes' characteristics were analyzed. Niosomes were prepared using both the green UP technique and traditional thin-film hydration (TFH) technique, which requires the use of environmentally hazardous organic solvents. The studied surfactant systems were Span 20, Pluronic L64, and their mixture (Span 20 and Pluronic L64)...
September 7, 2016: AAPS PharmSciTech
Muhammad Imran Khan, Asadullah Madni, Leena Peltonen
The aim of the study was to develop a niosomal drug delivery system for poorly soluble drugs withsorbitan monolaurate, poloxamer 184 and their mixture (sorbitan monolaurate and poloxamer 184) forming the niosomal surfactant system. Diacerein, a highly lipophilic antiosteoarthritic drug, was used as a model drug: it has variable oral bioavailability due to its poor aqueous solubility. The diacerein loaded niosomes were prepared with 1:1, 6:4 and 7:3 surfactant to cholesterol ratios at constant levels of dicetyl phosphate (2...
September 3, 2016: European Journal of Pharmaceutical Sciences
Tamer Shehata, Toshikiro Kimura, Kazutaka Higaki, Ken-Ichi Ogawara
Three different nonionic surfactants (Brij 72, Span 20 and Tween 60) were used to prepare various naked and PEG niosomes. In-vivo study demonstrated that PEGylation dramatically increased the AUC and decreased the affinity to the liver of Brij 72 and Span 20 niosomes in rats. Liver perfusion experiments suggested that the hepatic uptake of naked Brij 72 and Span 20 niosomes could mainly be ascribed to the receptor-mediated uptake, while PEGylation of these niosomes could diminish the receptor-mediated hepatic disposition...
October 15, 2016: International Journal of Pharmaceutics
Shery Jacob, Anroop B Nair, Bandar E Al-Dhubiab
Niosomes suggest a versatile vesicle delivery system with possible transport of drugs via topical route for skin delivery. The aim of the present research was to optimize niosome gel formulation of acyclovir and evaluate in both in vitro and in vivo rabbit model. Niosome formulations were formulated by coacervation phase separation technique with different ratios of non-ionic surfactants, phospholipids and cholesterol using 3(2) factorial design. Altering the surfactant concentration has influenced the drug entrapment, but not vesicle size...
August 25, 2016: Journal of Liposome Research
Jiradej Manosroi, Charinya Chankhampan, Puxvadee Chaikul, Worapaka Manosroi, Aranya Manosroi
Hair lotion containing methyl myristate loaded in cationic niosomes (HL-MMnio) composed of Brij72/cholesterol/DDAB at 7:3:0.65 molar ratio was developed. The remaining percentages of MM loaded in cationic niosomes in hair lotion were higher than free MM in hair lotion of about 1.2 times. The cumulative amounts in rat skin and the receiver compartment of MM loaded in cationic niosomes incorporated in hair lotion were higher than those of free MM in hair lotion of 1.45 and 1.32 times, respectively. HL-MMnio showed very slightly irritation on rabbit skin, which was disappeared after 4 days...
August 24, 2016: Journal of Microencapsulation
Mohammed A Kassem, Hossam S El-Sawy, Fathy I Abd-Allah, Tamer M Abdelghany, Khalid M El-Say
This research purposed to formulate an optimized imatinib mesylate (IM)-loaded niosomes to improve its chemotherapeutic efficacy. The influence of 3 formulation factors on niosomal vesicular size (Y1), zeta potential (Y2), entrapment capacity percentage (Y3), the percentage of initial drug release after 2 h (Y4), and the percentage of cumulative drug release after 24 h (Y5) were studied and optimized using Box-Behnken design. Optimum desirability was specified and the optimized formula was prepared, stability tested, morphologically examined, checked for vesicular bilayer formation and evaluated for its in vitro cytotoxicity on 3 different cancer cell lines namely MCF-7, HCT-116, and HepG-2 in addition to 1 normal cell line to ensure its selectivity against cancer cells...
August 17, 2016: Journal of Pharmaceutical Sciences
Ayat Allam, Gihan Fetih
The aim of the present work was to prepare and evaluate sublingual fast dissolving films containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for prolonged release of the drug, whereas the films were used to increase the drug's bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for size, zeta-potential, and entrapment efficiency. The selected niosomal formulation was incorporated into polymeric films using hydroxypropyl methyl cellulose E15 and methyl cellulose as film-forming polymers and Avicel as superdisintegrant...
2016: Drug Design, Development and Therapy
Lorena Tavano, Loredana Mauro, Giuseppina Daniela Naimo, Leonardo Bruno, Nevio Picci, Sebastiano Andò, Rita Muzzalupo
The loading of chemotherapics into smart nanocarriers that simultaneously possess more than one useful property for specifically targeting a tumor site improves their therapeutic effectiveness, reducing their side effects. Hence, we proposed a combined approach for the treatment of human breast cancer (BC) consisting of the co-encapsulation of doxorubicin and curcumin or doxorubicin and quercetin into multifunctional niosomes, which results in prolonged blood circulation and an ability to spontaneously accumulate at the tumor site (passive target) and to recognize and bind the tumor cells through dual ligand-receptor interactions (active target)...
September 6, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Saeid Moghassemi, Afra Hadjizadeh, Amirhossien Hakamivala, Kobra Omidfar
Controlled delivery of signaling factors could be a great approach in the tissue engineering field. Nano-niosomal drug delivery systems offer numerous advantages for this purpose. The present study reports the formulation and evaluation of a growth factor (GF)-loaded nano-niosome-hydrogel composite for GF delivery to modulate cell behavior. Niosomes were prepared, using span 60 surfactant with cholesterol (CH) in diethyl ether solvent, by reverse-phase evaporation technique. Basic fibroblast growth factor (bFGF) and bovine serum albumin (BSA) were loaded simultaneously and the final suspension was embedded into agarose hydrogel...
August 8, 2016: AAPS PharmSciTech
Lorena Tavano, Rita Muzzalupo
Delivering chemotherapy specifically, effectively and safely to tumor remains a significant challenge in recent years. Although cancer cells are more vulnerable than normal to the effect of anticancer agents, these drugs are non-selective and can cause injury to normal tissues. Different approaches i.e. passive, active and magnetic targeting, smart devices with appropriate stimuli-sensitive properties or drugs combinations, have been already proposed as single methods, contributing to minimize severe side effects and enhancing tumor-targeting efficacy...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
C Ingallina, F Rinaldi, A Bogni, J Ponti, D Passeri, M Reggente, M Rossi, A Kinsner-Ovaskainen, D Mehn, F Rossi, B Botta, M Carafa, C Marianecci
The majority of active agents do not readily permeate into brain due to the presence of the blood-brain barrier and blood-cerebrospinal fluid barrier. Currently, the most innovative and promising non-invasive strategy in brain delivery is the design and preparation of nanocarriers, which can move through the brain endothelium. Niosomes can perform brain delivery, in fact polysorbates, can act as an anchor for apolipoprotein E from blood plasma. The particles mimic LDL and interact with the LDL receptor leading to the endothelial cells uptake...
September 25, 2016: International Journal of Pharmaceutics
Worranan Rangsimawong, Praneet Opanasopit, Theerasak Rojanarata, Suwannee Panomsuk, Tanasait Ngawhirunpat
The effect of sonophoresis on the transdermal drug delivery of sodium fluorescein (NaFI)-loaded lipid nanocarriers such as liposomes (LI), niosomes (NI) and solid lipid nanoparticles (SLN) was investigated by confocal laser scanning microscopy (CLSM), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results showed that SN decreased the skin penetration of NaFI-loaded SLN (6.32-fold) and NI (1.79-fold), while it increased the penetration of NaFI-loaded LI (5.36-fold)...
August 30, 2016: Pharmaceutical Development and Technology
Lorena Tavano, Cesare Oliviero Rossi, Nevio Picci, Rita Muzzalupo
Inclusion of lipids or polymers with a transition temperature closer to physiological body temperature (40-42°C) is a strategy used in tumor therapy for more than 30 years, because it allows induction of drug release from delivery systems by mild hyperthermia. Unfortunately, most of these thermo-sensitive carriers are removed from circulation before completion of their function. Thus, novel multi-functional niosomes possessing spontaneous stealth and thermo-sensitive properties were developed from L64 Pluronic(®) and L64ox as its derivative, in presence or absence of cholesterol...
September 25, 2016: International Journal of Pharmaceutics
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