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Ana Claudia Pompeu Raminelli, Valeria Romero, Mohammad H Semreen, Gislaine Ricci Leonardi
The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Herein we highlight further advances and an update on tretinoin delivery systems such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrins, nanostructured polymers and other technological systems that reduce its side effects and improve the permeation profile to potentiate efficacy and drug safety on the skin...
March 12, 2018: Current Medicinal Chemistry
Boshra Amiri, Hasan Ahmadvand, Ali Farhadi, Aazam Najmafshar, Mohsen Chiani, Dariush Norouzian
Vinblastine (VB), as a chemotherapeutic agent, is widely used in treatment of different types of cancer. However, its clinical application is limited due to its low water solubility, side effects and multidrug resistance. The aim of this study was to increase the therapeutic efficacy of VB using drug delivery systems. For this purpose, a PEGylated niosomal formulation of vinblastine (Pn-VB) was prepared by thin film hydration method and physicochemically characterized. Drug release pattern was performed by dialysis diffusion method...
March 13, 2018: Drug Development and Industrial Pharmacy
Aroonsri Priprem, Teerasak Damrongrungruang, Sucharat Limsitthichaikoon, Bhattaranitch Khampaenjiraroch, Chatchanok Nukulkit, Suthasinee Thapphasaraphong, Wanwisa Limphirat
Anthocyanins from dietary sources showing potential benefits as anti-inflammatory in oral lesions were developed as an anthocyanin complex (AC), comprised of extracts of Zea mays (CC) and Clitoria ternatea (CT), and formulated into a niosome gel to prove its topical oral wound healing in vitro and in vivo investigations. The AC formed nano-sized clusters of crystalline-like aggregates, occurring through both intra- and inter-molecular interactions, resulting in delivery depots of anthocyanins, following encapsulation in niosomes and incorporation into a mucoadhesive gel...
March 12, 2018: AAPS PharmSciTech
Irhan Ibrahim Abu Hashim, Noha Fawzy Abo El-Magd, Ahmed Ramadan El-Sheakh, Mohammed Fawzy Hamed, Abd El-Gawad Helmy Abd El-Gawad
The goal of the current study was to explore the potential benefits of Acitretin (Act) nanovesicular gel as a prospective antipsoriatic topical delivery system counteracting the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. Act-loaded niosomes were successfully developed, entirely characterized, and optimized. Further evaluation of the optimized formula was conducted regarding its stability and ex vivo cytotoxicity on different cell lines...
2018: International Journal of Nanomedicine
Shahla Kakoei, Abbas Pardakhty, Maryam-Al-Sadat Hashemipour, Hasan Larizadeh, Behjat Kalantari, Elaheh Tahmasebi
Statement of the Problem: A significant proportion of patients undergoing chemotherapy or radiotherapy suffer from mucositis. The first symptom of oral mucositis is pain. Severe pain, burning sensation, and discomfort in the oral cavity make it difficult to continue treatment and even continue living in these patients. Purpose: The aim of this study was to evaluate and compare the effect of amitriptyline mouthwash (in two forms of simple and niosomal) as a local anesthetic agent with benzydamine HCl mouthwash in oral mucositis after radiotherapy or chemotherapy...
March 2018: Journal of Dentistry
Heba F Salem, Rasha M Kharshoum, Fatma I Abo El-Ela, Amr Gamal F, Khaled R A Abdellatif
Tamoxifen citrate (TXC) is commonly indicated to prevent cell multiplication and development of breast cancer. However, it is usually associated with limited activity and development of toxicity and resistance. This study aimed to describe an in situ pH-responsive niosomes as a carrier for localized and sustained delivery of TXC. The thin film hydration method was utilized to produce TXC niosomes using sorbitan monostearate and cholesterol of 1:1 Molar ratio. The produced formula displayed nano-spherical shape with entrapment efficiency (EE) of 88...
February 27, 2018: Drug Delivery and Translational Research
Eva Judy, Darshna Pagariya, Nand Kishore
Oral bioavailability of a drug molecule requires its effective delivery to the target site. In general, majority of synthetically developed molecular entities have high hydrophobic nature as well as low bioavailability, therefore the need for suitable delivery vehicles arises. Self-assembled structures such as micelles, niosomes, and liposomes have been used as effective delivery vehicles and studied extensively. However, the information available in literature is mostly qualitative in nature. We have quantitatively investigated the partitioning of antibiotic drug streptomycin into cationic, non-ionic and mixture of cationic and non-ionic surfactant micelles and its interaction with the transport protein serum albumin upon subsequent delivery...
February 26, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Asadullah Madni, Muhammad Abdur Rahim, Muhammad Ahmad Mahmood, Abdul Jabar, Mubashar Rehman, Hassan Shah, Arshad Khan, Nayab Tahir, Aamna Shah
Proniosomes (PN) are the dry water-soluble carrier systems that may enhance the oral bioavailability, stability, and topical permeability of therapeutic agents. The low solubility and low oral bioavailability due to extensive first pass metabolism make Pentazocine as an ideal candidate for oral and topical sustained release delivery. The present study was aimed to formulate the PNs by quick slurry method that are converted to niosomes (liquid dispersion) by hydration, and subsequently formulated to semisolid niosomal gel...
February 22, 2018: AAPS PharmSciTech
Bhupinder Kapoor, Reena Gupta, Sachin Kumar Singh, Monica Gulati, Saranjit Singh
With the advent from the laboratory bench to patient bedside in last five decades, vesicular systems have now come to be widely accepted as pragmatic means for controlled delivery of drugs. Their success stories include those of liposomes, niosomes and even the lately developed ethosomes and transferosomes. Pharmacosomes, which, as delivery systems offer numerous advantages and have been widely researched, however, remain largely unacknowledged as a successful delivery system. Though a large number of drugs have been derivatized and formulated into self-assembled vesicular systems, the term pharmacosomes has not been widely used while reporting them...
February 7, 2018: Advances in Colloid and Interface Science
Mona G Arafa, Bassam M Ayoub
No abstract text is available yet for this article.
February 16, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Rania K Eid, Ebtessam A Essa, Gamal M El Maghraby
The fluidity of vesicular membrane affects vesicular transdermal drug delivery. Essential oils can be located in vesicular membrane imparting flexibility and influencing transdermal delivery. Accordingly, the objective was to investigate the effect of incorporation of essential oils in niosomes on felodipine transdermal delivery. Rigid niosomes comprising Span 60 with cholesterol (2:1, w/w) were used with clove, eucalyptus or lemon oils being incorporated in the vesicles at increasing concentrations. The vesicle size and shape was monitored using scanning electron microscopy...
February 14, 2018: Pharmaceutical Development and Technology
Mahmoud S Soliman, Fathy I Abd-Allah, Talib Hussain, Noha M Saeed, Hossam S El-Sawy
OBJECTIVE: An optimized Date seed oil (DSO) loaded niosomes was formulated. SIGNIFICANCE: Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention and treatment purposes. METHODS: By using Box-Behnken Design, the effect of 3 formulation factors on the entrapment efficiency percentage (Y1), initial DSO release percentage after 2 h (Y2), and cumulative DSO release percentage of DSO after 12 h (Y3), were optimized and studied...
February 8, 2018: Drug Development and Industrial Pharmacy
Lorena Tavano, Elisabetta Mazzotta, Rita Muzzalupo
HYPOTHESIS: Due to the well-know surfactant-like properties of diclofenac sodium (DS), vesicular systems consisting exclusively of DS, named diclosomes, were designed with the aim to minimize or avoid the use of other excipients and to improve the formulation biocompatibility. EXPERIMENTS: Diclosomes were designed and characterized in terms of dimensions, polydispersity index, ξ-potential, drug retained, stability as a function of storage time and ex-vivo percutaneous permeation profiles...
January 29, 2018: Colloids and Surfaces. B, Biointerfaces
Melanie Tavares, Márcio Robert Mattos da Silva, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Lolita Bodjolle-d'Almeira, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn)...
February 2, 2018: International Journal of Pharmaceutics
Joyline Dsa, Manish Goswami, B R Singh, Nidhi Bhatt, Pankaj K Sharma, Meenakshi Chauhan
We present a novel approach of designing and fabricating a non-invasive drug delivery device which is capable of delivering the drug to the target site in a controlled manner. The device utilizes a reservoir which can be reused once the drug has completely diffused from it. This micro-reservoir based fabricated device has been successfully tested using niosomes of insulin drug filled in, which was then sealed with a magnetic membrane of 20µm thick and was actuated by applying magnetic field. The deflection of the membrane on application of magnetic field results in the drug release from the reservoir...
February 2, 2018: Drug Development and Industrial Pharmacy
Mohamed Ali, Amira Abdel Motaal, Mohammed A Ahmed, Abdulrhman Alsayari, Omaima N El-Gazayerly
The active compounds present in Hypericum perforatum L. (Hypericaceae) include hyperforin, hypericins and flavonoids, which are assumed to be responsible for the activity of the extract in the treatment of wounds and scars. The present study aimed to incorporate H. perforatum extract standardized to a known content of phloroglucinols, naphthodianthrones and polyphenolic compounds into an effective transdermal drug delivery system capable of entrapping both lipophilic and hydrophilic constituents in the form of niosomal gels for wound treatment...
November 2018: Drug Delivery
Kamal Dua, Dyandevi Mathure, Jyotsana R Madan, Kishore N Gujar, Ashok Tupsamundre, Hemant A Ranpise
Considering various merits associated with the nasal mucosa such large surface area, porous endothelial membrane, high blood flow, avoidance of first-pass metabolism, and ready accessibility leads to faster and higher drug absorption. Keeping these facts in mind, the objective of the present study was to develop Buspirone hydrochloride loaded niosomal in-situ nasal gel. Buspirone hydrochloride niosomal in-situ nasal gel was formulated, optimized and evaluated with the aim to deliver drug to the brain via intranasal route...
January 29, 2018: Pharmaceutical Nanotechnology
Noppharat Phadungcharoen, Samarwadee Plianwong, Chakrit Srivichai, Natcha Chanthananon, Watcharawat Kaosal, Ornkamon Pannil, Praneet Opanasopit, Tanasait Ngawhirunpat, Theerasak Rojanarata
To achieve efficient and safe cationic carrier-mediated gene delivery for gene therapy, the optimal ratio of carrier to DNA in formulations is a key factor and it is usually determined prior to transfection experiments. In this work, a simplified drop-and-read assay was developed for the first time using paper as a platform to estimate the equivalence ratio of cationic carriers to negatively charged DNA. By spotting a series of complexes containing varied ratios of carrier to DNA on filter paper, then allowing them to dry and finally dropping yellowish-green anionic 2',7'-dichlorofluorescein dye solution on top of the complexes, the equivalence point was detectable by the instant formation of stable pink spots as a result of the dye adsorption onto the positively charged complexes and free carriers...
January 21, 2018: European Journal of Pharmaceutical Sciences
Muhammad Zia Ullah Khan, Shujaat Ali Khan, Muhammad Ubaid, Aamna Shah, Rozina Kousar, Ghulam Murtaza
Androgenetic alopecia, generally recognized as male pattern baldness, is a gradually developing medical and physiological change, which is manifested by continuous hair-loss from scalp. Finasteride (4-aza-3-oxosteroid) is a potent anti-baldness compound that selectively and competitively inhibits the 5α-reductase isoenzymes. Prolonged oral use of finasteride leads to the emergence of sexual disorders including decrease in libido, gynecomastia, erectile dysfunction, ejaculation disorder, orgasm disorders and mood disturbances...
January 23, 2018: Current Drug Delivery
Diana E Aziz, Aly A Abdelbary, Abdelhalim I Elassasy
Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart their lipid bilayer with ultra-flexibility to trespass SC by high self-optimizing deformability. To confirm this hypothesis, this work aimed at developing novel bilosomes by modulating conventional niosomal composition using different bile salts as EAs and investigating their superiority over niosomes for transdermal delivery of diacerein (DCN), as model drug...
January 21, 2018: Journal of Liposome Research
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