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https://www.readbyqxmd.com/read/28420295/optimization-of-methotrexate-loaded-niosomes-by-box-behnken-design-an-understanding-of-solvent-effect-and-formulation-variability
#1
Ahmed S Zidan, Mahmoud Mokhtar Ibrahim, Nagia A El Megrab
Dermal drug delivery system which localizes methotrexate (MTX) in the skin is advantageous in topical treatment of psoriasis. The aim of the current study was to understand dilution effects and formulation variability for the potential formation of niosomes from proniosome gels of MTX. Box-Behenken design was employed to prepare a series of MTX proniosome gels of Span 40, cholesterol (Chol-X1) and Tween 20 (T20-X2). Short chain alcohols (X3), namely ethanol (Et), propylene glycol (Pg) and glycerol (G) were evaluated for their dilution effects on proniosomes...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28408818/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingiber-cassumunar-roxb-by-therapeutic-ultrasound-in-a-rat-model
#2
Jirakrit Leelarungrayub, Jiradej Manorsoi, Aranya Manorsoi
OBJECTIVE: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28377276/encapsulation-systems-for-the-delivery-of-hydrophilic-nutraceuticals-food-application
#3
REVIEW
N P Aditya, Yadira Gonzalez Espinosa, Ian T Norton
Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers...
April 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28375753/microniosomes-for-concurrent-doxorubicin-and-iron-oxide-nanoparticles-loading-preparation-characterization-and-cytotoxicity-studies
#4
Behzad Behnam, Mohammad Rezazadehkermani, Saeid Ahmadzadeh, Ahad Mokhtarzadeh, Seyed Noureddin Nematollahi-Mahani, Abbas Pardakhty
The current work deals with developing a suitable drug delivery system of doxorubicin (DOX) for intraperitoneal chemotherapy using niosomes through formulating non-ionic surfactants consisting of Brij™ 52, span™ 60 and Solulan™ C24. Entrapping the magnetite nanoparticles in the hydrophilic parts of niosomes was accompanied with high-efficient DOX loading by the current novel remote-loading method. Cytotoxicity of the prepared formulations was evaluated in vitro against A549 and PC-12 cell lines using the colorimetric WST-1 assay test...
April 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28347807/retinal-gene-delivery-enhancement-by-lycopene-incorporation-into-cationic-niosomes-based-on-dotma-and-polysorbate-60
#5
Mohamed Mashal, Noha Attia, Gustavo Puras, Gema Martínez-Navarrete, Eduardo Fernández, Jose Luis Pedraz
The present study aimed to evaluate the incorporation of the natural lipid lycopene into niosome formulations based on cationic lipid DOTMA and polysorbate 60 non-ionic surfactant to analyze the potential application of this novel formulation to deliver genetic material into the rat retina. Both niosomes with and without lycopene were prepared by the reverse phase evaporation method and physicochemically characterized in terms of size, zeta potential, polydispersity index and capacity to condense, release and protect the DNA against enzymatic digestion...
March 24, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28345332/effects-of-cisplatin-loaded-niosomal-nanoparticleson-bt-20-human-breast-carcinoma-cells
#6
Leila Kanaani, Iraj Javadi, Meysam Ebrahimifar, Hasan Ebrahimi Shahmabadi, Azim Akbarzadeh Khiyav, Torkan Mehrdiba
Breast cancer is the fifth most common cause of death among women worldwide. Resistance to cisplatin is a main challenge in its treatment. Our present aim was to prepare nanoniosomated cisplatin and examine its efficacy in vitro using the BT-20 cell line. Niosome nanoparticles containing cisplatin were prepared by reverse-phase evaporation and characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), spectrophotometry and MTT assay. The size and zeta potential of the nanodrug were estimated as 489...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28330377/enhanced-oral-bioavailability-and-sustained-delivery-of-glimepiride-via-niosomal-encapsulation-in-vitro-characterization-and-in-vivo-evaluation
#7
Amira Mohamed Mohsen, Mona Mahmoud AbouSamra, Shaimaa Ahmed ElShebiney
This study was designed to investigate the potency of niosomes, for glimepiride (GLM) encapsulation, aiming at enhancing its oral bioavailability and hypoglycemic efficacy. Niosomes containing non-ionic surfactants (NIS) were prepared by thin film hydration technique and characterized. In-vitro release study was performed using a dialysis technique. In-vivo pharmacodynamic studies, as well as pharmacokinetic evaluation were performed on alloxan induced diabetic rats. GLM niosomes exhibited high entrapment efficiency percentages (E...
March 23, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28323149/the-effect-of-tobramycin-incorporated-with-bismuth-ethanedithiol-loaded-on-niosomes-on-the-quorum-sensing-and-biofilm-formation-of-pseudomonas-aeruginosa
#8
Faeze Mahdiun, Shahla Mansouri, Payam Khazaeli, Rasoul Mirzaei
Pseudomonas aeruginosa is an opportunistic pathogen, enable of causing infections especially in immunocompromised patients. Recently many isolates developed multiple drug resistance, resulting in treatment failure in serious infections. In this study, the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm production by P. aeruginosa was evaluated. Thin layer hydration method with cholesterol (30%), Span 40 and Tween 40 were used to make niosomes...
March 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28302110/beneficial-effects-of-a-coriolus-versicolor-based-vaginal-gel-on-cervical-epithelization-vaginal-microbiota-and-vaginal-health-a-pilot-study-in-asymptomatic-women
#9
Santiago Palacios, Fernando Losa, Damián Dexeus, Javier Cortés
BACKGROUND: To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, Coriolus versicolor, Asian centella, Azadirachta indica and Aloe vera on vaginal microbiota, cervical epithelization and vaginal health. METHODS: Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index...
March 16, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28292243/injectable-drug-loaded-nanocarriers-for-lung-cancer-treatments
#10
Huang-Ping Yu, Ibrahim A Aljuffali, Jia-You Fang
Different types of injectable nanoparticles, including metallic nanoparticles, polymeric nanocarriers, dendrimers, liposomes, niosomes, and lipid nanoparticles, have been employed to load drugs for lung delivery. Nanoparticles used for lung delivery offer some benefits over conventional formulations, including increased solubility, enhanced stability, improved epithelium permeability and bioavailability, prolonged half-life, tumor targeting, and minimal side effects. In recent years, the concept of using injectable nanocarriers as vehicles for drug delivery has attracted increasing attention...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28268943/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#11
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266539/improved-bioavailability-and-antitumor-effect-of-docetaxel-by-tpgs-modified-proniosomes-in-vitro-and-in-vivo-evaluations
#12
Helong Liu, Liangxing Tu, Yongxin Zhou, Zefang Dang, Luting Wang, Junfeng Du, Jianfang Feng, Kaili Hu
A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, -18.53 ± 1.65 mV in zeta potential and exhibited spherical morphology, with an encapsulation efficiency of 97.31 ± 0.60%. The system showed sustained release in both simulated gastric and intestinal fluid. The results of caco-2 monolayer, everted gut sac model and improved single-pass intestinal perfusion model transport studies showed that DTX-TPGS-PN niosomes could significantly improve the absorption of DTX...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28240177/formulation-of-niosomal-gel-for-enhanced-transdermal-lornoxicam-delivery-in-vitro-and-in-vivo-evaluation
#13
Mohamed Shafik El-Ridy, Soad Aly Yehia, Amira Mohamed Mohsen, Sally A El-Awdan, Asmaa Badawy Darwish
The objective of this study was to investigate the potential of niosomal gels as a transdermal delivery system to improve the permeation and anti-inflammatory activity of Lornoxicam (LX). LX niosomes were prepared by thin film hydration technique and were characterized using Transmission Electron Microscopy (TEM), Differential Scanning Calorimetry (DSC), Particle Size analysis and Zeta potential determination. LX niosomal gel/ LX loaded gel were prepared using Carbopol 934 (2%) and were evaluated for their physical appearance, pH and rheological behaviour...
February 24, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28228079/lipid-based-nanoparticles-as-carriers-for-dermal-delivery-of-antioxidants
#14
Lucia Montenegro
The skin, being the outermost layer of our body, is constantly exposed to oxidative stress induced by UV-radiation, pollutants, smoke and xenobiotics. To counteract the deleterious effects of such exposure, the skin is equipped with a complex anti-oxidation system, involving both exogenous and endogenous antioxidants. As low molecular weight antioxidants undergo depletion in counteracting oxidative stress occurring in the skin, topical supplementation with these agents is regarded as a suitable strategy to restore skin oxidative balance...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28228078/nanocarriers-mediated-topical-drug-delivery-for-psoriasis-treatment
#15
Sevgi Güngör, Meriem Rezigue
BACKGROUND: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28227149/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#16
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Marc-Andre Fortin, Eric Boilard, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28169546/colloidal-vesicular-system-of-inositol-hexaphosphate-to-counteract-dmba-induced-dysregulation-of-markers-pertaining-to-cellular-proliferation-differentiation-and-inflammation-of-epidermal-layer-in-mouse-model
#17
Malti Arya, Prakash Tiwari, Chandra Bhushan Tripathi, Poonam Parashar, Mahendra Singh, Priyam Sinha, Narayan P Yadav, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf
Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate (IP6), a natural bioactive constituent of cereals, legumes, etc., has momentous potential as an antiangiogenic agent, that specifically affects malignant cells. The shortcoming is its quick absorption on oral/topical administration. Niosomes are flexible carriers for topical drug delivery. The central venture of current research was to optimize and characterize niosomal delivery system of IP6 for treatment of skin cancer...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28165822/in-vitro-and-in-vivo-investigation-for-optimization-of-niosomal-ability-for-sustainment-and-bioavailability-enhancement-of-diltiazem-after-nasal-administration
#18
H O Ammar, M Haider, M Ibrahim, N M El Hoffy
Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28163981/current-advances-in-5-aminolevulinic-acid-mediated-photodynamic-therapy
#19
Connor Thunshelle, Rui Yin, Qiquan Chen, Michael R Hamblin
Kennedy and Pottier discovered that photodynamic therapy (PDT) could be carried out using a procedure consisting of topical application of the porphyrin-precursor, 5-aminolevulinic acid (ALA) to the skin, followed after some time by illumination with various light parameters in the 1980s. Since then, ALA-PDT has expanded enormously and now covers most aspects of dermatological disease. The purpose of this review is to discuss a range of ingenious strategies that investigators have devised for improving the overall outcome (higher efficiency and lower side effects) of ALA-PDT...
September 2016: Current Dermatology Reports
https://www.readbyqxmd.com/read/28157445/creatinine-based-non-phospholipid-vesicular-carrier-for-improved-oral-bioavailability-of-azithromycin
#20
Shafi Ullah, Muhammad Raza Shah, Mohammad Shoaib, Muhammad Imran, Syed Wadood Ali Shah, Imdad Ali, Farid Ahmed
CONTEXT: Novel, safe, efficient and cost effective nano-carriers from renewable resources have got greater interest for enhancing solubility and bioavailability of hydrophobic dugs. OBJECTIVES: This study reports the synthesis of a novel biocompatible non-phospholipid human metabolite "Creatinine" based niosomal delivery system for Azithromycin improved oral bioavailability. METHODS: Synthesized surfactant was characterized through spectroscopic and spectrometric techniques and then the potential for niosomal vesicle formation was evaluated using Azithromycin as model drug...
June 2017: Drug Development and Industrial Pharmacy
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