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https://www.readbyqxmd.com/read/28169546/colloidal-vesicular-system-of-inositol-hexaphosphate-to-counteract-dmba-induced-dysregulation-of-markers-pertaining-to-cellular-proliferation-differentiation-and-inflammation-of-epidermal-layer-in-mouse-model
#1
Malti Arya, Prakash Tiwari, Chandra Bhushan Tripathi, Poonam Parashar, Mahendra Singh, Priyam Sinha, Narayan P Yadav, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf
Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate (IP6), a natural bioactive constituent of cereals, legumes etc., has momentous potential as an antiangiogenic agent, that specifically affects malignant cells. The shortcoming is its quick absorption on oral/ topical administration. Niosomes are flexible carriers for topical drug delivery. The central venture of current research was to optimize and characterize niosomal delivery system of IP6 for treatment of skin cancer...
February 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28165822/in-vitro-and-in-vivo-investigation-for-optimization-of-niosomal-ability-for-sustainment-and-bioavailability-enhancement-of-diltiazem-after-nasal-administration
#2
H O Ammar, M Haider, M Ibrahim, N M El Hoffy
Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28163981/current-advances-in-5-aminolevulinic-acid-mediated-photodynamic-therapy
#3
Connor Thunshelle, Rui Yin, Qiquan Chen, Michael R Hamblin
Kennedy and Pottier discovered that photodynamic therapy (PDT) could be carried out using a procedure consisting of topical application of the porphyrin-precursor, 5-aminolevulinic acid (ALA) to the skin, followed after some time by illumination with various light parameters in the 1980s. Since then, ALA-PDT has expanded enormously and now covers most aspects of dermatological disease. The purpose of this review is to discuss a range of ingenious strategies that investigators have devised for improving the overall outcome (higher efficiency and lower side effects) of ALA-PDT...
September 2016: Current Dermatology Reports
https://www.readbyqxmd.com/read/28157445/creatinine-based-non-phospholipid-vesicular-carrier-for-improved-oral-bioavailability-of-azithromycin
#4
Shafi Ullah, Muhammad Raza Shah, Mohammad Shoaib, Muhammad Imran, Syed Wadood Ali Shah, Imdad Ali, Farid Ahmed
CONTEXT: Novel, safe, efficient and cost effective nano-carriers from renewable resources have got greater interest for enhancing solubility and bioavailability of hydrophobic dugs. OBJECTIVES: This study reports the synthesis of a novel biocompatible non-phospholipid human metabolite "Creatinine" based niosomal delivery system for Azithromycin improved oral bioavailability. METHODS: Synthesized surfactant was characterized through spectroscopic and spectrometric techniques and then evaluated for niosomal vesicles formation potential using Azithromycin as model drug...
February 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28134262/doe-optimization-of-nano-based-carrier-of-pregabalin-as-hydrogel-new-therapeutic-chemometric-approaches-for-controlled-drug-delivery-systems
#5
Mona G Arafa, Bassam M Ayoub
Niosomes entrapping pregabalin (PG) were prepared using span 60 and cholesterol in different molar ratios by hydration method, the remaining PG from the hydrating solution was separated from vesicles by freeze centrifugation. Optimization of nano-based carrier of pregabalin (PG) was achieved. Quality by Design strategy was successfully employed to obtain PG-loaded niosomes with the desired properties. The optimal particle size, drug release and entrapment efficiency were attained by Minitab(®) program using design of experiment (DOE) that predicted the best parameters by investigating the combined effect of different factors simultaneously...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28126673/niosome-based-hydrogel-of-resveratrol-for-topical-applications-an-effective-therapy-for-pain-related-disorder-s
#6
Poonam Negi, Madhur Aggarwal, Gajanand Sharma, Charul Rathore, Gaurav Sharma, Bhupinder Singh, O P Katare
The present work endeavors for development and evaluation of resveratrol loaded niosomal hydrogel system for its anti-inflammatory action. Niosomes were prepared by thin film hydration and ether injection methods employing Span 80 as a surfactant at three different levels. Best optimized formulation was selected on the basis of entrapment efficiency (% EE), mean particle size, sedimentation volume, and microscopy. The vesicular and spherical nature of the niosomes was confirmed by optical microscopy and transmission electron microscope (TEM)...
January 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28119103/topical-delivery-of-roxithromycin-solid-state-forms-entrapped-in-vesicles
#7
Candice Csongradi, Jeanetta du Plessis, Marique Elizabeth Aucamp, Minja Gerber
Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated into vesicle systems (niosomes, proniosomes, ufosomes and pro-ufosomes) for dermis targeted delivery. Characterization of the vesicles was done with transmission electron microscopy, light microscopy, droplet size, droplet size distribution, pH, zeta-potential and entrapment efficiency percentage...
January 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28114822/ph-sensitive-niosomes-effects-on-cytotoxicity-and-on-inflammation-and-pain-in-murine-models
#8
Federica Rinaldi, Elena Del Favero, Valeria Rondelli, Stefano Pieretti, Alessia Bogni, Jessica Ponti, François Rossi, Luisa Di Marzio, Donatella Paolino, Carlotta Marianecci, Maria Carafa
pH-sensitive nonionic surfactant vesicles (niosomes) by polysorbate-20 (Tween-20) or polysorbate-20 derivatized by glycine (added as pH sensitive agent), were developed to deliver Ibuprofen (IBU) and Lidocaine (LID). For the physical-chemical characterization of vesicles (mean size, size distribution, zeta potential, vesicle morphology, bilayer properties and stability) dynamic light scattering (DLS), small angle X-ray scattering and fluorescence studies were performed. Potential cytotoxicity was evaluated on immortalized human keratinocyte cells (HaCaT) and on immortalized mouse fibroblasts Balb/3T3...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28078954/nanovesicle-delivery-to-the-liver-via-retinol-binding-protein-and-platelet-derived-growth-factor-receptors-how-targeting-ligands-affect-biodistribution
#9
Ching-Yun Hsu, Chun-Han Chen, Ibrahim A Aljuffali, You-Shan Dai, Jia-You Fang
AIM: Nanovesicles (NVs) conjugating ligands can deliver to the specific nidus. We designed a nanosystem targeting the injectable niosomes to liver for examining biodistribution. METHODOLOGY: Vitamin A and antiplatelet-derived growth factor receptor antibody were employed as the ligands to be taken by hepatic stellate cells. The biodistribution in rats was visualized by bioimaging. RESULTS: A significant liver accumulation was detected for antibody-embedded NVs at 2 h after dosing...
January 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28067087/oral-delivery-of-allopurinol-niosomes-in-treatment-of-gout-in-animal-model
#10
Neelu Singh, Poonam Parashar, Chandra Bhushan Tripathi, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
CONTEXT: Gout is a painful disorder which does not have an efficient delivery system for its treatment. OBJECTIVE: Development and in vitro, in vivo evaluation of allopurinol-loaded nonionic surfactant-based niosomes was envisaged. MATERIALS AND METHODS: Niosomes were prepared with Span 20 and Tween 20 (1:1 molar ratio) using ether injection method. The formulations were screened for entrapment efficiency, particle size analysis, zeta potential, release kinetics, in vivo activity, and stability studies...
February 1, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/27979250/%C3%AE-tocopherol-loaded-niosome-prepared-by-heating-method-and-its-release-behavior
#11
Ladan Basiri, Ghadir Rajabzadeh, Aram Bostan
α-Tocopherol-loaded niosome was developed using modified heating method. The influence of surfactants (Span60 and Tween60) in different mole ratios, presence or absence of cholesterol (Chol) and dicetyl phosphate (DCP) as well as different concentration of α-tocopherol (α-TOC) on mean size, polydispersity index, zeta potential and entrapment efficiency (EE) was evaluated. The results showed that α-TOC loaded niosomes exhibited a small mean size (73.85±0.6-186±0.58nm), narrow size distribution and high EE (61...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27977311/flurbiprofen-loaded-niosomes-in-gel-system-improves-the-ocular-bioavailability-of-flurbiprofen-in-the-aqueous-humor
#12
Marwa M El-Sayed, Amal K Hussein, Hatem A Sarhan, Heba F Mansour
The present work aimed to prolong the contact time of flurbiprofen (FBP) in the ocular tissue to improve the drug anti-inflammatory activity. Different niosome systems were fabricated adopting thin-film hydration technique and using the nonionic surfactant Span 60. The morphology of the prepared niosomes was characterized by scanning electron microscopy (SEM). Physical characterization by differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy were conducted for the optimized formula (F5) that was selected on the basis of percent entrapment efficiency, vesicular size and total lipid content...
January 31, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27956194/enhancement-of-8-methoxypsoralen-topical-delivery-via-nanosized-niosomal-vesicles-formulation-development-in-vitro-and-in-vivo-evaluation-of-skin-deposition
#13
Ahmed Alaa Kassem, Sameh Hosam Abd El-Alim, Marwa Hasanein Asfour
The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol at five different molar ratios. The obtained vesicles revealed high entrapment efficiencies (83.04-89.90%) with nanometric vesicle diameters (111.1-198.8nm) of monodisperse distribution (PDI=0.145-0.216), zeta potential values <-48...
December 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27933988/niosomes-consisting-of-tween-60-and-cholesterol-improve-the-chemical-stability-and-antioxidant-activity-of-epigallocatechin-gallate-under-intestinal-tract-conditions
#14
Rong Liang, Ling Chen, Wallace Yokoyama, Peter A Williams, Fang Zhong
In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF)...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27904075/in-vitro-permeation-and-skin-retention-of-%C3%AE-mangostin-proniosome
#15
Gan Siaw Chin, Hiroaki Todo, Wesam Radhi Kadhum, Mariani Abdul Hamid, Kenji Sugibayashi
The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27886514/sugar-based-novel-niosomal-nanocarrier-system-for-enhanced-oral-bioavailability-of-levofloxacin
#16
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali
CONTEXT: Vesicular systems have attracted great attention in drug delivery because of their amphiphilicity, biodegradability, non-toxicity and potential for increasing drug bioavailability. OBJECTIVE: A novel sugar-based double-tailed surfactant containing renewable block was synthesized for preparing niosomal vesicles that could be exploited for Levofloxacin encapsulation, aiming to increase its oral bioavailability. MATERIALS AND METHODS: The surfactant was characterized by (1)H NMR, mass spectroscopy and Fourier transform infrared spectroscopy (FT-IR)...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27863986/microfluidics-based-manufacture-of-liposomes-simultaneously-entrapping-hydrophilic-and-lipophilic-drugs
#17
Sameer Joshi, Maryam T Hussain, Carla B Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J Kirby, Yvonne Perrie
Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production methods for liposomes. Therefore, the aim of our research has been to consider the application of microfluidics in the manufacture of liposomes containing either or both a water soluble and a lipid soluble drug to promote co-delivery of drugs...
September 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863660/microfluidics-based-manufacture-of-liposomes-simultaneously-entrapping-hydrophilic-and-lipophilic-drugs
#18
Sameer Joshi, Maryam T Hussain, Carla B Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J Kirby, Yvonne Perrie
Despite the substantial body of research investigating the use of liposomes, niosomes and other bilayer vesicles for drug delivery, the translation of these systems into licensed products remains limited. Indeed, recent shortages in the supply of liposomal products demonstrate the need for new scalable production methods for liposomes. Therefore, the aim of our research has been to consider the application of microfluidics in the manufacture of liposomes containing either or both a water soluble and a lipid soluble drug to promote co-delivery of drugs...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27855894/proniosomal-powders-of-natural-canthaxanthin-preparation-and-characterization
#19
Maryam Ravaghi, Chiara Sinico, Seyed Hadi Razavi, Seyed Mohammad Mousavi, Elena Pini, Anna Maria Fadda
In this study, canthaxanthin (CTX) was produced by Dietzia natronolimnaea HS-1 using beetroot molasses as substrate and used for encapsulation in proniosome powders after extraction, with the aim of improving its stability. Proniosome powders were prepared with an equimolar ratio of span 60/cholesterol and four different carriers, namely maltodextrin, mannitol, lactose and pullulan. The properties of these formulations as both proniosomal powders and resulted niosomal dispersions were evaluated. The type of carriers had significant effects on the micrometric properties of proniosome powders which were further confirmed by the results of SEM analysis...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27837536/environmental-scanning-electron-microscope-imaging-of-vesicle-systems
#20
Yvonne Perrie, Habib Ali, Daniel J Kirby, Afzal U R Mohammed, Sarah E McNeil, Anil Vangala
The structural characteristics of liposomes have been widely investigated and there is certainly a strong understanding of their morphological characteristics. Imaging of these systems, using techniques such as freeze-fracturing methods, transmission electron microscopy, and cryo-electron imaging, has allowed us to appreciate their bilayer structures and factors which can influence this. However, there are few methods which all us to study these systems in their natural hydrated state; commonly the liposomes are visualized after drying, staining, and/or fixation of the vesicles...
2017: Methods in Molecular Biology
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