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https://www.readbyqxmd.com/read/27914345/biopolymer-matrix-for-nano-encapsulation-of-urease-a-model-protein-and-its-application-in-urea-detection
#1
Abhishek Saxena, Arpita Bhattacharya, Satish Kumar, Irving R Epstein, Rachana Sahney
Alginate microparticles and nanoparticles crosslinked with Ca(+2) ions are frequently employed in biomedical applications. Here we use microemulsion polymerization to prepare alginate nanoparticles (nanogels) using different crosslinking ions (Ca(+2), Sr(+2), Ba(+2)) to encapsulate a model protein, urease enzyme (jackbeans). With alginate concentrations of 0.2wt% in the aqueous phase, emulsion droplets showed good stability and narrow, monomodal distributions with radii ∼65±10nm. The size of the nanogel varies with the crosslinking cation and its affinity for the mannuronate and guluronate units in the linear alginate chain...
November 9, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914040/formulation-optimization-and-ex-vivo-and-in-vivo-evaluation-of-celecoxib-microemulsion-based-gel-for-transdermal-delivery
#2
Mengyuan Cao, Lili Ren, Guoguang Chen
Celecoxib (CXB) is a poorly aqueous solubility sulfonamide non-steroidal anti-inflammatory drug (NSAID). Hence, the formulation of CXB was selected for solubilization and bioavailability. To find out suitable formulation for microemulsion, the solubility of CXB in triacetin (oil phase), Tween 80 (surfactant), and Transcutol-P (co-surfactant) was screened respectively and optimized by using orthogonal experimental design. The Km value and concentration of oil, Smix, and water were confirmed by pseudo-ternary phase diagram studies and central composite design...
December 2, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27913654/novel-small-molecule-jp-153-targets-the-src-fak-paxillin-signaling-complex-to-inhibit-vegf-induced-retinal-angiogenesis
#3
Jordan J Toutounchian, Jayaprakash Pagadala, Duane D Miller, Jerome Baudry, Frank Park, Edward Chaum, Charles R Yates
Targeting vascular endothelial growth factor (VEGF) is a common treatment strategy for neovascular eye disease, a major cause of vision loss in diabetic retinopathy and age-related macular degeneration. However, the decline in clinical efficacy over time in many patients suggests that monotherapy of anti-VEGF protein therapeutics may benefit from adjunctive treatments. Our previous work has shown that through decreased activation of the cytoskeletal protein paxillin, growth factor-induced ischemic retinopathy in the murine oxygen-induced retinopathy model could be inhibited...
January 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/27910752/submicron-emulsions-and-their-applications-in-oral-delivery
#4
Veenu Mundada, Mitali Patel, Krutika Sawant
A "submicron emulsion" is an isotropic mixture of drug, lipids, and surfactants, usually with hydrophilic cosolvents and with droplet diameters ranging from 10 to 500 nm. Submicron emulsions are of increasing interest in medicine due to their kinetic stability, high solubilizing capacity, and tiny globule size. Because of these properties, they have been applied in various fields, such as personal care, cosmetics, health care, pharmaceuticals, and agrochemicals. Submicron emulsions are by far the most advanced nanoparticulate systems for the systemic delivery of biologically active agents for controlled drug delivery and targeting...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27906143/microemulsion-synthesis-of-silver-nanoparticles-using-biosurfactant-extracted-from-pseudomonas-aeruginosa-mkvit3-strain-and-comparison-of-their-antimicrobial-and-cytotoxic-activities
#5
Moonjit Das, Kaustuvmani Patowary, Radhakrishnan Vidya, Himaja Malipeddi
In the present study, an efficient biosurfactant producing bacterial strain Pseudomonas aeruginosa MKVIT3 was isolated from an oil logging area in Vellore district of Tamil Nadu, India. Liquid chromatography-mass spectrometry (LC-MS/MS) analysis was performed for the identification of different congeners present in the extracted biosurfactant. The column purified biosurfactant was used to stabilise the formation of silver nanoparticles (NP) using borohydrate reduction in reverse micelles. The silver NP were characterised using UV-vis absorption spectroscopy, Powder-XRD TEM analysis and zeta potential...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27887040/in-vitro-assessment-of-non-irritant-microemulsified-voriconazole-hydrogel-system
#6
Prasanna Raju Y, Hyndavi N, Harini Chowdary V, Rajesh S Nair, Jamal Basha D, Tejeswari N
Research was aimed on microemulsion-based hydrogel for voriconazole. Oleic acid and isopropyl myristate as lipid phases; tween 20: tween 80 as surfactants and PEG600 as cosurfactant were selected to formulate voriconazole microemulsions. The promising microemulsions in terms of zeta potential, pH, viscosity, and drug release were selected and developed into hydrogels using carbopol 934. Resulting microemulsion-based hydrogel (MBH) of voriconazole were evaluated for in vitro diffusion and ex vivo permeation...
November 25, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27885736/palladium-nanoparticles-encapsulated-in-hollow-titanosilicate-spheres-as-an-ideal-nanoreactor-for-one-pot-oxidation
#7
Yasutaka Kuwahara, Takahiro Ando, Hiroto Kango, Hiromi Yamashita
One-pot reaction involving Pd-catalyzed H2 O2 production from H2 and O2 and Ti-catalyzed successive oxidation with H2 O2 in a single reaction vessel is an alluring strategy for the synthesis of targeted chemicals in terms of sustainability and economic competitiveness. In this study, a yolk-shell nanostructured catalyst, consisting of Pd nanoparticles (NPs) with core diameter ca. 4.0 nm and a porous titanosilicate shell of ca. 15 nm thickness, was fabricated by using an oil-in-water (O/W) microemulsion-based interfacial self-assembly approach...
November 25, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27885330/formulation-of-propolis-phenolic-acids-containing-microemulsions-and-their-biopharmaceutical-characterization
#8
Modestas Žilius, Kristina Ramanauskienė, Vaida Juškaitė, Vitalis Briedis
Microemulsions (MEs) were formulated using PEG-8 caprylic/capric glycerides and ethanolic propolis extracts. Characterization of MEs was performed by determining mean droplet size, polydispersity index, stability under varying external factors, and formulation effect on delivery of phenolic compounds into the skin ex vivo. Essential oils were included into the formulations of MEs and their influence on physical characteristics of the nanostructured systems as well as penetration into epidermis and dermis were evaluated...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27871215/formulation-characterization-and-in-vitro-ex-vivo-evaluation-of-quercetin-loaded-microemulsion-for-topical-application
#9
Azar Kajbafvala, Alireza Salabat, Anayatollah Salimi
The aim of this study was to develop a new microemulsion formulation for topical application of poorly soluble drug named quercetin. In order to design suitable microemulsion system, the pseudo-ternary phase diagrams of microemulsion systems were constructed at different surfactant/co-surfactant ratios using tween 80 as surfactant, transcutol® P as co-surfactant and oleic acid as oil phase. Some physicochemical properties such as droplet size, density, refractive index, electrical conductivity, pH, surface tension and viscosity of the microemulsion systems were measured at 298...
November 22, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27866256/surfactant-free-microemulsion-electrokinetic-chromatography-sf-meekc-with-uv-and-ms-detection-a-novel-approach-for-the-separation-and-esi-ms-detection-of-neutral-compounds
#10
Urška Mohorič, Andrea Beutner, Sebastian Krickl, Didier Touraud, Werner Kunz, Frank-Michael Matysik
Microemulsion electrokinetic chromatography (MEEKC) is a powerful tool to separate neutral species based on differences in their hydrophobic and hydrophilic properties. However, as a major drawback the conventionally used SDS based microemulsions are not compatible with electrospray ionization mass spectrometry (ESI-MS). In this work, a surfactant-free microemulsion (SFME) consisting of water, ethanol, and 1-octanol is used for surfactant-free microemulsion electrokinetic chromatography (SF-MEEKC). Ammonium acetate was added to the SFME enabling electrophoretic separations...
December 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27862742/microemulsions-options-to-expand-the-synthesis-of-inorganic-nanoparticles
#11
REVIEW
Silke Wolf, Claus Feldmann
Microemulsions (MEs) are ideal for obtaining high-quality inorganic nanoparticles. As thermodynamically stable systems with a nanometer-sized droplet phase that serves as a nanoreactor, MEs have obvious advantages for the synthesis of nanoparticles. MEs also have disadvantages, such as their complexity as multicomponent systems, the low amount of obtainable nanoparticles, their limited thermal stability, the fact that hydrolyzable or oxidizable compounds are often excluded from synthesis, the partly elaborate separation of nanoparticles, as well as the removal of surface-adhered surfactants subsequent to synthesis...
November 15, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27858253/microemulsion-transdermal-formulation-for-simultaneous-delivery-of-valsartan-and-nifedipine-formulation-by-design
#12
Jatin Sood, Bharti Sapra, Ashok K Tiwary
The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of two poorly soluble antihypertensive drugs. Surface response methodology of Box-Behnken design was utilized to evaluate the effect of two oils (Captex 500 - x1 and Capmul MCM - x2) and surfactant (Acrysol EL135 - x3) on response y1 (particle size), y2 (solubility of valsartan), and y3 (solubility of nifedipine). The important factors which significantly affected the responses were identified and validated using ANOVA...
November 17, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27834055/biopharmaceutical-assessment-and-irritation-potential-of-microemulsions-and-conventional-systems-containing-oil-from-syagrus-cearensis-for-topical-delivery-of-amphotericin-b-using-alternative-methods
#13
Giovana D Sousa, Juliana Kishishita, Kátia A S Aquino, Octávio A F Presgrave, Leila B Leal, Davi P Santana
The aim of this study was to compare the biopharmaceutical characteristics and irritation potentials of microemulsions (MEs) and conventional systems (CSs) containing oil from Syagrus cearensis for topical delivery of Amphotericin B (AmB). Pseudo-ternary phase diagrams were constructed using a water titration method to develop the MEs, and the CSs were prepared according to the classical technique of phase inversion. In the skin permeation and retention study, dermatomed pig skin without stratum corneum was used as an alternative disturbed skin model...
November 10, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27823927/physical-mechanisms-of-micro-and-nanodomain-formation-in-multicomponent-lipid-membranes
#14
REVIEW
Friederike Schmid
This article summarizes a variety of physical mechanisms proposed in the literature, which can generate micro- and nanodomains in multicomponent lipid bilayers and biomembranes. It mainly focusses on lipid-driven mechanisms that do not involve direct protein-protein interactions. Specifically, it considers (i) equilibrium mechanisms based on lipid-lipid phase separation such as critical cluster formation close to critical points, and multiple domain formation in curved geometries, (ii) equilibrium mechanisms that stabilize two-dimensional microemulsions, such as the effect of linactants and the effect of curvature-composition coupling in bilayers and monolayers, and (iii) non-equilibrium mechanisms induced by the interaction of a biomembrane with the cellular environment, such as membrane recycling and the pinning effects of the cytoplasm...
November 5, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27808665/mucoadhesive-nanostructured-lipid-carriers-nlcs-as-potential-carriers-for-improving-oral-delivery-of-curcumin
#15
Saipon Chanburee, Waree Tiyaboonchai
PURPOSE: To examine effects of polymer types on the mucoadhesive properties of polymer coated NLCs Experiment: Curcumin-loaded NLCs were prepared using a warm microemulsion technique followed by coating particle surface with mucoadhesive polymers; polyethylene glycol400 (PEG400), polyvinyl alcohol (PVA) and chitosan (CS). The physicochemical properties and entrapment efficacy were examined. In vitro mucoadhesive studies were assessed by wash-off test. In addition, the stability of mucoadhesive NLCs in gastrointestinal fluids and the pattern of drug release were also investigated...
November 3, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27803494/preparation-of-conjugated-linoleic-acid-microemulsions-and-their-biodistribution
#16
Kazuaki Kishita, Kayo Ibaraki, Shoko Itakura, Yumi Yamasaki, Naoko Nishikata, Kenji Yamamoto, Masataka Shimizu, Kazuo Nishiyama, Masao Yamasaki
Conjugated linoleic acid (CLA) has several beneficial biological properties. Specifically, trans10, cis12-CLA, one of the CLA isomers, has strong physiologic activity against cancer and obesity. However, compared with cis9, trans11-CLA, a naturally occurring CLA isomer, trans10, cis12-CLA tends to be easily metabolized. Therefore, to make efficient use of its biological properties, it is necessary to overcome the rapid clearance of trans10, cis12-CLA from the blood. Here, we employed premix membrane emulsification to prepare two oil-in-water CLA microemulsions (CLA-ME), 100 nm CLA-ME and 200 nm CLA-ME, and investigated their pharmacokinetics in a mouse model...
2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27802901/percutaneous-penetration-of-anticancer-agents-past-present-and-future
#17
REVIEW
Kevin Ita
Cancer occurs as a result of alterations in oncogenes, tumor-suppressor genes, and microRNA genes. Over the past few decades, efforts have been made to understand the dominant oncogenes and tumor suppressor genes whose respective activation/upregulation or loss of function serve to impart aberrant properties on normal cells. Cancer continues to be a source of public health concern due to widespread prevalence, morbidity and mortality. The most common types include but are not limited to lung, prostate, colorectal, breast, ovarian and skin cancers...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27802617/polymer-loaded-microemulsions-changeover-from-finite-size-effects-to-interfacial-interactions
#18
B Kuttich, O Ivanova, I Grillo, B Stühn
Form fluctuations of microemulsion droplets are observed in experiments using dielectric spectroscopy (DS) and neutron spin echo spectroscopy (NSE). Previous work on dioctyl sodium sulfosuccinate based water in oil microemulsions in the droplet phase has shown that adding a water soluble polymer (Polyethylene glycol M = 1500 g mol(-1)) modifies these fluctuations. While for small droplet sizes (water core radius rc < 37 Å) compared to the size of the polymer both methods consistently showed a reduction in the bending modulus of the surfactant shell as a result of polymer addition, dielectric spectroscopy suggests the opposite behaviour for large droplets...
October 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27800146/antimicrobial-activity-of-biocompatible-microemulsions-against-aspergillus-niger-and-herpes-simplex-virus-type-2
#19
Mayson H Alkhatib, Magda M Aly, Rajaa A Rahbeni, Khadijah S Balamash
BACKGROUND: Microemulsions (MEs), which consist of oil, water, surfactants, and cosurfactants, have recently generated considerable interest as antimicrobial agents. OBJECTIVES: To determine the antifungal and antiviral activities of three ME formulations (MEa, MEb, and MEc) that differ in their hydrophilicity. METHODS: The ME formulas were produced by mixing different fractions of Tween 80, Span 20, ethanol, oil, isopropyl myristate, and distilled water...
September 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27789371/microwave-assisted-formulation-of-solid-lipid-nanoparticles-loaded-with-non-steroidal-anti-inflammatory-drugs
#20
Rohan M Shah, Daniel S Eldridge, Enzo A Palombo, Ian H Harding
Stearic acid-based solid lipid nanoparticles (SLNs) were prepared using the microwave assisted one-pot microemulsions procedure pioneered by our group. In this study, non-steroidal anti-inflammatory drugs (NSAIDs) including indomethacin, ketoprofen and nimesulide were selected as ideal "test" drugs, based on their poor water solubility. The model drugs were incorporated within the SLNs by the microwave-assisted procedure at the time of SLN production. The microwave-produced drug-loaded SLNs were evaluated in terms of their physicochemical characteristics, drug release behavior and their uptake into against A549 cell line (human lung epithelial cells)...
October 24, 2016: International Journal of Pharmaceutics
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