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https://www.readbyqxmd.com/read/29160824/microneedle-assisted-percutaneous-delivery-of-a-tetramethylpyrazine-loaded-microemulsion
#1
Qiang Zu, Yanyan Yu, Xiaolin Bi, Ren Zhang, Liuqing Di
This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN). The TMP-ME formulation was optimized in vitro with skin permeation experiments, using a uniform experimental design, guided by a pseudo-ternary phase diagram, in which the TMP skin permeation level and mean particle size were indices. The effects of MN pretreatment on skin permeation by TMP-ME were assessed using in vitro skin permeation, in vivo skin microdialysis, and pharmacokinetic studies in rats...
November 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29159584/correction-to-optimized-synthesis-of-novel-prenyl-ferulate-performed-by-feruloyl-esterases-from-myceliophthora-thermophila-in-microemulsions
#2
Io Antonopoulou, Laura Leonov, Peter Jütten, Gabriella Cerullo, Vincenza Faraco, Adamantia Papadopoulou, Dimitris Kletsas, Marianna Ralli, Ulrika Rova, Paul Christakopoulos
After publication of the original article, authors found that there has been a minor mistake in the units of kcat and kcat/Km in Table 2. The units should be 10(3) min(-1) g(-1) FAE for kcat and mM(-1) min(-1) g(-1) FAE for kcat/Km. This correction does not affect any conclusions drawn within the article.
November 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29156598/novel-montmorillonite-tio%C3%A2-mnal-mixed-oxide-composites-prepared-from-inverse-microemulsions-as-combustion-catalysts
#3
Bogna D Napruszewska, Alicja Michalik-Zym, Melania Rogowska, Elżbieta Bielańska, Wojciech Rojek, Adam Gaweł, Monika Wójcik-Bania, Krzysztof Bahranowski, Ewa M Serwicka
A novel design of combustion catalysts is proposed, in which clay/TiO₂/MnAl-mixed oxide composites are formed by intermixing exfoliated organo-montmorillonite with oxide precursors (hydrotalcite-like in the case of Mn-Al oxide) obtained by an inverse microemulsion method. In order to assess the catalysts' thermal stability, two calcination temperatures were employed: 450 and 600 °C. The composites were characterized with XRF (X-ray fluorescence), XRD (X-ray diffraction), HR SEM (high resolution scanning electron microscopy, N₂ adsorption/desorption at -196 °C, and H₂ TPR (temperature programmed reduction)...
November 19, 2017: Materials
https://www.readbyqxmd.com/read/29155597/aggregation-and-rheological-behavior-of-the-lavender-oil-pluronic-p123-microemulsions-in-water-ethanol-mixed-solvents
#4
Oyais Ahmad Chat, Nighat Nazir, Parvaiz Ahmad Bhat, Puthusserickal Abdulrahiman Hassan, Vinod Kumar Aswal, Aijaz Ahmad Dar
The effect of lavender oil on aggregation characteristics of P123 in aqueous-ethanolic solutions is investigated systematically by DLS, SANS and Rheology. The solubilization capacity of the formulation increased by increasing P123 concentration. The study unveiled the importance of the short chain alcohol-ethanol, as solubilization enhancer. The apparent hydrodynamic radius (Rh) increased significantly with increase in lavender oil concentration up to maximum oil solubilization capacity of the copolymer at a particular ethanol concentration...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29150967/drug-delivery-strategies-for-chemoprevention-of-uvb%C3%A2-induced-skin-cancer-a-review
#5
REVIEW
Arvind Bagde, Arindam Mondal, Mandip Singh
Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed towards improvements in terms of delivery modes, therapeutic agents and site-specificity of therapeutics delivery...
November 18, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29150729/effect-of-microemulsion-structure-on-fluorescence-and-nonlinear-optical-properties-of-rhodamine-6g
#6
M Pourtabrizi, N Shahtahmassebi, A Kompany, S Sharifi
This study is conducted to investigate the effect of nano-droplets concentration and size on linear and nonlinear optical properties of Rhodamine 6G by UV-Vis, spectrofluorometer and Z-Scan techniques. Nano-droplets were prepared by mixture of AOT, n-Decane and Water at three different water to surfactant molar ratios (W = 3, 6.7 and 40) and two dye to water mass ratios (R). At high enough dye concentration, the fluorescence intensity and its red shift depend on the concentration of dye in water nano-droplets (R)...
November 18, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29148709/nir-emitting-nanoprobes-based-on-cyclic-rgd-motif-conjugated-pbs-quantum-dots-for-integrin-targeted-optical-bioimaging
#7
Nicoletta Depalo, Michela Corricelli, Ivan de Paola, Gianpiero Valente, Rosa M Iacobazzi, Emiliano Altamura, Doriana Debellis, Daniela Comegna, Elisabetta Fanizza, Nunzio Denora, Valentino Laquintana, Fabio Mavelli, Marinella Striccoli, Michele Saviano, Angela Agostiano, Annarita Del Gatto, Laura Zaccaro, Maria Lucia Curri
Here, silica coated PbS quantum dots (QDs) with photoluminesce emission properties in the near-infrared (NIR) region are proposed as potential effective single particle optical nanoprobes for future in vivo imaging of tumors. The dispersibility in aqueous medium of hydrophobic PbS QDs was accomplished by growing a silica shell on their surface by exploiting a base assisted water-in-oil microemulsion method. The silica coated PbS QDs were then conjugated with specifically designed cyclic arginine-glycine-aspartic acid (cRGD) peptide, that are able to specifically recognizes the αvβ3 integrins which is overexpressed in the angiogenic tumor induced vasculatures and on some solid tumours, in order to achieve a tumor-specific targeting...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29144306/characterization-of-a-hybrid-polyacrylamide-and-its-flocculation-properties-in-cyanide-tailing-suspensions
#8
Ya Liu, Cuicui Lv, Jian Ding, Peng Qian, Yang Yu, Shufeng Ye, Yunfa Chen
An inorganic-organic hybrid flocculant Al(OH)3-polyacrylamide (Al-PAM) with narrow molecular weight distribution was synthesized using inverse microemulsion polymerization. The hybrid polymer Al-PAM was characterized by Infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy and scanning electron microscopy, and it was found that it had a 'star-like' structure in which Al(OH)3 colloidal particles acted as cores linking PAM chains. The properties of Al-PAM were investigated in flocculating 10 wt% cyanide tailing suspensions...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29141534/characterization-methods-for-solid-lipid-nanoparticles-sln-and-nanostructured-lipid-carriers-nlc
#9
Velichka Andonova, Petya Peneva
BACKGROUND: Solid lipid nanoparticles (SLN) and the next generation of nanostructured lipid carriers (NLC) seem to be a very promising alternative to other colloidal carriers such as liposomes, microemulsions, and polymeric nanoparticles. These combine the advantages of the cited nanocarriers and can improve the dissolution rate in biological fluids, increase the drug absorption, improve the tissue distribution in the target organ, enhance the drug bioavailability and ensure controlled drug release...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29138064/bicontinuous-microemulsions-as-a-biomembrane-mimetic-system-for-melittin
#10
Douglas G Hayes, Ran Ye, Rachel N Dunlap, Divina B Anunciado, Sai Venkatesh Pingali, Hugh M O'Neill, Volker S Urban
Antimicrobial peptides effectively kill antibiotic-resistant bacteria by forming pores in prokaryotes' biomembranes via penetration into the biomembranes' interior. Bicontinuous microemulsions, consisting of interdispersed oil and water nanodomains separated by flexible surfactant monolayers, are potentially valuable for hosting membrane-associated peptides and proteins due to their thermodynamic stability, optical transparency, low viscosity, and high interfacial area. Here, we show that bicontinuous microemulsions formed by negatively-charged surfactants are a robust biomembrane mimetic system for the antimicrobial peptide melittin...
November 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29130769/neuroprotective-effects-and-uplc-q-tof-ms-based-active-components-identification-of-external-applied-a-novel-wen-luo-tong-microemulsion
#11
Hong-Mei Lin, Long-Fei Lin, Zhen-Zhen Xia, Yong Mao, Jia Liu, Ling-Yan Xu, Qing Wu
Chemotherapy induced neuropathy causes excruciating pain to cancer patients. Wen-Luo-Tong (WLT), a traditional Chinese medicinal compound, has been used to alleviate anti-cancer drug such as oxaliplatin-induced neuropathic pain for many years. However, the current route of administration of WLT is inconvenient and the active ingredients and mechanism of action of WLT are still unclear. To address these issues, we developed a novel formulation of WLT (W/O microemulsion) for the ease of application. New ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) methods were employed for analysis of the ingredients...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29123482/anticancer-activities-of-surfactin-and-potential-application-of-nanotechnology-assisted-surfactin-delivery
#12
REVIEW
Yuan-Seng Wu, Siew-Ching Ngai, Bey-Hing Goh, Kok-Gan Chan, Learn-Han Lee, Lay-Hong Chuah
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis, and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticancer activity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29119940/development-of-floating-delivery-for-solid-self-micro-emulsifying-drug-delivery-system-of-prochlorperazine-maleate
#13
Swati Jagdale, Mayuri Shinde
Background Prochlorperazine maleate(PCM) is a phenothiazine antipsychotic used in the treatment of nausea, vomiting and vertigo. It is BCS class II drug with only 12.5% bioavailability. Patents data on PCM had shown work on conjugation and matrix formulation which suggested idea for the present work design. Objective The objective of this study was to enhance solubility of drug and to optimize gastro retentive floating capsule for controlled drug release at the targeted site for stipulated time. Method The solubility of drug was determined in various vehicles like oils, surfactants and co-surfactants...
November 7, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29116804/coupled-interfacial-tension-and-phase-behavior-model-based-on-micellar-curvatures
#14
Victor Torrealba, Russell T Johns
This paper introduces a consistent and robust model that predicts interfacial tensions for all microemulsion Winsor types and overall compositions. The model incorporates film bending arguments and Huh's equation, and is coupled to phase behavior so that simultaneous tuning of both interfacial tension (IFT) and phase behavior is possible. The oil-water interfacial tension and characteristic length are shown to be related to each other through the hydrophilic-lipophilic deviation (). The phase behavior is tied to the micelle curvatures, without the need for using net average curvature (NAC)...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29111749/unravelling-the-formation-mechanism-of-dendritic-fibrous-nanosilica
#15
Ayan Maity, Avik Das, Debasis Sen, Subhasish Mazumder, Vivek Polshettiwar
We studied the formation mechanism of dendritic fibrous nanosilica (DFNS) that involves several intriguing dynamical steps. Through electron microscopy and real-time small-angle X-ray scattering studies, it has been demonstrated that the structural evolu-tion of bi-continuous microemulsion droplets (BMDs) and their subsequent coalescence, yielding nano-reactor template, is responsible for to the formation of complex DFNS morphology. The role of co-surfactant has been found to be quite crucial, which allowed the understanding of this intricate mechanism involving the complex interplay of self-assembly, dynamics of BMDs formation and coa-lescence...
November 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29108575/agarose-hydrogel-containing-immobilized-ph-buffer-microemulsion-without-increasing-permselectivity
#16
Miguel Coll Crespi, Gaston A Crespo, Xiaojiang Xie, Romain Touilloux, Marylou Tercier-Waeber, Eric Bakker
A heterogeneous pH buffer based on a colloidal emulsion containing ion-exchanger and lipophilic base is described that can be integrated into hydrogels without affecting their ion-exchange properties. Each sphere works on the basis of reversible ion-exchange of hydrogen ions with solution cations, acting as a pH buffer while staying removed from solution in the nonpolar core of the spheres. The ion-exchange mechanism is supported by titration experiments in aqueous emulsion, showing that the nature and concentration of the exchanging solution cations influences the buffer action, with increasing lipophilicity moving the equilibrium to lower pH values...
January 15, 2018: Talanta
https://www.readbyqxmd.com/read/29107614/solid-lipid-nanoparticles-as-carriers-for-oral-delivery-of-hydroxysafflor-yellow-a
#17
Bingxiang Zhao, Sufang Gu, Yong Du, Minjie Shen, Xiangrui Liu, Youqing Shen
Hydroxysafflor yellow A (HSYA) is the main bioactive flavonoid extracted from the flower of Carthamus tinctorius L., which is widely used in traditional Chinese medicine for the treatment of myocardial ischemia and cerebral ischemia. HSYA has high water solubility but poor intestinal membrane permeability, resulting in low oral bioavailability. Currently, only HSYA sodium chloride injection has been approved for clinical use and oral formulations are urgently needed. In this study, HSYA solid lipid nanoparticles (SLNs) with the structure of w/o/w were prepared by a warm microemulsion process using approved drug excipients for oral delivery to increase the oral absorption of HSYA...
October 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29104058/ionic-liquid-microemulsions-assisting-in-the-transdermal-delivery-of-dencichine-preparation-in-vitro-and-in-vivo-evaluations-and-investigation-of-the-permeation-mechanism
#18
Chengxiao Wang, Junxiao Zhu, Ding Zhang, Ye Yang, Luyao Zheng, Yuan Qu, Xiaoyan Yang, Xiuming Cui
A novel microemulsion was developed and characterized for topical delivery of Dencichine (Den). Two imidazaolium ionic liquid, 1-hydroxyethyl-3-methylimidazolium chloride ([HOEIM]Cl) and 1-butyl-3-methylimidazolium dodecanesulfate ([BMIM]C12SO3) were incorporated into the aqueous and surfactant phases respectively for the remarkable enhancement on skin permeation. The nano-carrier was developed and optimized based on a pseudo-ternary phase diagram. The optimized formulation was composed of 50% water/[HOEIM]Cl mix (1:1) as water phase, 20% Tween 80/[BMIM]C12SO3 mix (1:1) as surfactant, 10% propylene glycol as co-surfactant and 20% IPM as oil phase...
November 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29102701/dna-interaction-anti-proliferative-effect-of-copper-oxide-nanocolloids-prepared-from-metallosurfactant-based-microemulsions-acting-as-precursor-template-and-reducing-agent
#19
Gurpreet Kaur, Varsha Dogra, Rajeev Kumar, Sandeep Kumar, Gaurav Bhanjana, Neeraj Dilbaghi, Nitin Kumar Singhal
In the present study, we have synthesized mixed cuprous/copper oxide nanosuspensions by metallosurfactant based microemulsion technique. Three metallosurfactants were synthesized which includes two non-ionic double chained metallosurfactants with C12, C16 chains with coordinated copper i.e. Cudda and Cuhexa, respectively. Another cationic double chained metallosurfactant with loosely bound metal (Cuctac) was also prepared. The prepared metallocomplexes were characterized using FTIR, elemental analysis, and NMR...
November 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29098874/prolonged-skin-retention-of-clobetasol-propionate-by-bio-based-microemulsions-a-potential-tool-for-scalp-psoriasis-treatment
#20
Rita Langasco, Sakine Tuncay Tanrıverdi, Özgen Özer, Marta Roldo, Massimo Cossu, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini
Novel effective and cosmetically acceptable formulations are needed for the treatment of scalp psoriasis, due to the poor efficacy of the current products. The challenge in developing safe, efficient and convenient delivery systems for this drug was addressed in the present work by formulating clobetasol propionate loaded W/O microemulsions. Pseudo-ternary phase diagrams were constructed by using a combination of biocompatible and biodegradable excipients. Characterization studies demonstrated that selected microemulsions had suitable technological features such as: being Newtonian fluids, possessing low viscosity and high thermodynamic stability...
November 3, 2017: Drug Development and Industrial Pharmacy
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