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Svetlana V Fedorenko, Svetlana L Grechkina, Asiya R Mustafina, Kirill V Kholin, Alexey S Stepanov, Irek R Nizameev, Ildus E Ismaev, Marsil K Kadirov, Rustem R Zairov, Alfia N Fattakhova, Rustem R Amirov, Svetlana E Soloveva
The present work introduces deliberate synthesis of Gd(III)-doped silica nanoparticles with high relaxivity at magnetic field strengths below 1.5T. Modified microemulsion water-in-oil procedure was used in order to achieve superficial localization of Gd(III) complexes within 40-55nm sized silica spheres. The relaxivities of the prepared nanoparticles were measured at 0.47, 1.41 and 1.5T with the use of both NMR analyzer and whole body NMR scanner. Longitudinal relaxivities of the obtained silica nanoparticles reveal significant dependence on the confinement mode, changing from 4...
October 14, 2016: Colloids and Surfaces. B, Biointerfaces
Ummara Butt, Amr ElShaer, Lori A S Snyder, Athina Chaidemenou, Raid G Alany
Fatty acids (FAs) are used by many organisms as defence mechanism against virulent bacteria. The high safety profile and broad spectrum of activity make them potential alternatives to currently used topical antibiotics for the treatment of eye infections in neonates. The current study utilised a Design of Experiment approach to optimise the quantification of five fatty acids namely; lauric acid, tridecanoic acid, myristoleic acid, palmitoleic acid and α-linolenic acid. The significance of the influence of the experimental parameters such as volume of catalyst, volume of n-hexane, incubation temperature, incubation time and the number of extraction steps on derivatisation was established by statistical screening with a factorial approach...
October 20, 2016: Drug Delivery and Translational Research
I Bravo-Osuna, V Andrés-Guerrero, P Pastoriza Abal, I T Molina-Martínez, R Herrero-Vanrell
Efficient treatment of ocular diseases can be achieved thanks to the proper use of ophthalmic formulations based on emerging pharmaceutical approaches. Among them, microtechnology and nanotechnology strategies are of great interest in the development of novel drug delivery systems to be used for ocular therapy. The location of the target site in the eye as well as the ophthalmic disease will determine the route of administration (topical, intraocular, periocular, and suprachoroidal administration) and the most adequate device...
October 20, 2016: Drug Delivery and Translational Research
Vanessa F Carvalho, Debora P de Lemos, Camila S Vieira, Amanda Migotto, Luciana B Lopes
In this study, non-aqueous microemulsions were developed because of the challenges associated with finding pharmaceutically acceptable solvents for topical delivery of drugs sparingly soluble in water. The formulation irritation potential and ability to modulate the penetration of lipophilic compounds (progesterone, α-tocopherol, and lycopene) of interest for topical treatment/prevention of skin disorders were evaluated and compared to solutions and aqueous microemulsions of similar composition. The microemulsions (ME) were developed with BRIJ, vitamin E-TPGS, and ethanol as surfactant-co-surfactant blend and tributyrin, isopropyl myristate, and oleic acid as oil phase...
October 18, 2016: AAPS PharmSciTech
Jing Li, Tengfei Fan, Yong Xu, Xuemin Wu
Emulsifiers for pesticide microemulsions contain a part of volatile organic compounds (VOCs), and ionic liquids (ILs) are becoming potential substitutes. In order to apply ILs in pesticide microemulsions, the study of interaction between ILs and surfactants is necessary. Therefore, the surface properties and aggregation of anionic surfactant sodium dodecyl sulfate (SDS) in ILs, including N-hexyl-N-methylmorpholinyl bromide ([C6mm][Br]), N-hexyl-N-methylpiperidyl bromide ([C6mp][Br]), N-hexyl-N-methylpyrrolidyl bromide ([C6mpyr][Br]), N-octyl-N-methylpyrrolidyl bromide ([C8mpyr][Br]), N-dodecyl-N-methylpyrrolidyl bromide ([C12mpyr][Br]) and N-hexadecyl-N-methylpyrrolidyl bromide ([C16mpyr][Br]), were investigated in terms of surface tension, conductivity, dynamic light scattering (DLS), viscosity, fluorescence, pseudo-ternary phase diagram and (1)H NMR measurements...
October 19, 2016: Physical Chemistry Chemical Physics: PCCP
Yung-Han Shih, Kuen-Yun Wang, Brenda T Singco, Chia-Her Lin, Hsi-Ya Huang
In this study, we first demonstrated the effect of two types of metal-organic framework-polymer (MOF-polymer) monoliths on in-tube solid-phase microextraction (IT-SPME) of sulfonamides. Sulfonamides were successfully adsorbed onto MIL-101(Cr)-polymer but were difficult to elute due to these sulfonamides could interact via Lewis acid-base interaction with the presence of Cr(III) coordinatively unsaturated metal sites (CUS). Moreover, the cage-type topology of MIL-101(Cr) that could produce multiple pathways thus complicates the desorption of the test analytes from the sorbent...
October 17, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Seim Timung, Joydip Chaudhuri, Manash Pratim Borthakur, Tapas Kumar Mandal, Gautam Biswas, Dipankar Bandyopadhyay
We report a facile and non-invasive way to disintegrate a microdroplet into a string of further miniaturized ones under the influence of an external electrohydrodynamic field inside a microchannel. The deformation and breakup of the droplet was engendered by the Maxwell's stress originating from the accumulation of induced and free charges at the oil-water interface. While at smaller field intensities, e.g. less than 1 MV/m, the droplet deformed into a plug, at relatively higher field intensities, e.g. ∼1...
October 17, 2016: Electrophoresis
Zhifeng Wang, Zhaojie Cui
A method using derivatization and supercritical fluid extraction coupled with gas chromatography was developed for the analysis of dimethylarsinate, monomethylarsonate and inorganic arsenic simultaneously in solid matrices. Thioglycolic acid n-butyl ester was used as a novel derivatizing reagent. A systematic discussion was made to investigate the effects of pressure, temperature, flow rate of the supercritical CO2 , extraction time, concentration of the modifier and microemulsion on extraction efficiency. The application for real environmental samples was also studied...
October 12, 2016: Journal of Separation Science
Ying Jin, Jiaying Xu, Lanfang Wang, Qingyi Lu, Feng Gao
In this study, mixed-metal sulfide Zn1-xMnxS nanorod-assembled hierarchical hollow spheres are successfully synthesized via a template-free solvothermal process base on Ostwald ripening process. In the reaction system the glycerol plays a key role for the formation of ZnxMn1-xS hierarchical hollow structures through a "quasi-microemulsion-template" mechanism. When applied as capacitor electrode material, the hierarchical Zn1-xMnxS hollow spheres display excellent electrochemical performances. Specifically, Zn0...
October 10, 2016: Chemistry: a European Journal
Tatsuo Maruyama, Naoki Ishizu, Yuka Eguchi, Takuya Hosogi, Masahiro Goto
We successfully implemented solvent extraction of short, single-stranded RNA using reverse micelles (water-in-oil microemulsions) with a DNA-surfactant. A thrombin-binding RNA aptamer was enzymatically synthesized and purified by extraction using the reverse micellar system. The extracted RNA aptamer retained thrombin-binding activity after the extraction procedure.
October 11, 2016: Chemical Communications: Chem Comm
Li-Hong Ye, Xi-De Liu, Jun Cao, Yan-Xu Chang, Mingrui An, Shu-Ling Wang, Jing-Jing Xu, Li-Qing Peng
A simple, efficient, and green chitosan-assisted liquid-solid extraction method was developed for the sample preparation of isoquinoline derivative alkaloids followed by microemulsion LC. The optimized mobile phase consisted of 0.8% w/v of ethyl acetate, 1.0% w/v of SDS, 8.0% w/v of n-butanol, 0.1% v/v acetic acid, and 10% v/v ACN. Compared to pharmacopoeia method and organic solvent extraction, this new approach avoided the use of volatile organic solvents, replacing them with relatively small amounts of chitosan...
October 4, 2016: Electrophoresis
Faranak Dehghani, Nafiseh Farhadian, Shiva Golmohammadzadeh, Amir Biriaee, Mahmoud Ebrahimi, Mohammad Karimi
The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral bioavailability due to its low aqueous solubility. To enhance the solubility of this drug, the microemulsion system was applied in form of oil-in-water. Sesame oil and Tween 80 were used as drug solvent oil and surfactant, respectively. Two different formulations were prepared for this purpose. The first formulation contained edible glycerin as co-surfactant and the second formulation contained Span 80 as a mixed surfactant...
September 27, 2016: European Journal of Pharmaceutical Sciences
Vianney Díaz-Blancas, Dora I Medina, Erika Padilla-Ortega, Raquel Bortolini-Zavala, Melissa Olvera-Romero, Gabriel Luna-Bárcenas
Tebuconazole (TBZ) nanoemulsions (NEs) were formulated using a low energy method. TBZ composition directly affected the drop size and surface tension of the NE. Water fraction and the organic-to-surfactant-ratio (RO/S) were evaluated in the range of 1-90 and 1-10 wt %, respectively. The study was carried out with an organic phase (OP) consisting of an acetone/glycerol mixture containing TBZ at a concentration of 5.4 wt % and Tween 80 (TW80) as a nonionic and Agnique BL1754 (AG54) as a mixture of nonionic and anionic surfactants...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Prabhakar Mishra, A P B Balaji, Swathy J S, Aruna L Paari, Merlyn Kezhiah, B K Tyagi, Amitava Mukherjee, Natarajan Chandrasekaran
Nanopesticides such as nanopermethrin can serve as an alternative to conventional pesticides causing eco-toxicity. The nanoformulation of this pyrethroid pesticide was carried out by solvent evaporation of pesticide-loaded microemulsion. The Z average for the nanopermethrin dispersion in paddy field water was found to be 169.2 ± 0.75 nm with a polydispersity index of 0.371 that exhibits uniform dispersion. Further, the nanopermethrin (NP) dispersion exhibited an effective stability in the paddy field water for a duration of 48 h with a Z average of 177...
September 27, 2016: Environmental Science and Pollution Research International
Tian Luo, Jianling Zhang, Xiuniang Tan, Chengcheng Liu, Tianbin Wu, Wei Li, Xinxin Sang, Buxing Han, Zhihong Li, Guang Mo, Xueqing Xing, Zhonghua Wu
Herein we propose for the first time the utilization of a metal complex for forming water-in-supercritical CO2 (scCO2 ) microemulsions. The water solubility in the metal-complex-stabilized microemulsion is significantly improved compared with the conventional water-in-scCO2 microemulsions stabilized by hydrocarbons. Such a microemulsion provides a promising route for the in situ CO2 reduction catalyzed by a metal complex at the water/scCO2 interface.
October 17, 2016: Angewandte Chemie
Xiao-Yan Liu, Xin Niu, Qian-Jin Feng, Xue-Zhi Yang, Dan-Wei Wang, Tong Zhao, Lei Li, Hong DU
The purpose of this study was to design and prepare a biocompatible microemulsion of Andrographis paniculata (BMAP) containing both fat-soluble and water-soluble constituents. We determined the contents of active constituents of BMAP and evaluated its bioavailability. The biocompatible microemulsion (BM), containing lecithin and bile salts, was optimized in the present study, showing a good physical stability. The mean droplet size was 19.12 nm, and the average polydispersity index (PDI) was 0.153. The contents of andrographolide and dehydroandrographolide in BMAP, as determined by high performance liquid chromatography (HPLC), were higher than that in ethanol extraction...
September 2016: Chinese Journal of Natural Medicines
Lu-Lu Wang, Shuai Huang, Hui-Hui Guo, Yan-Xing Han, Wen-Sheng Zheng, Jian-Dong Jiang
In situ administration of 5-fluorouracil (5FU) "thermosensitive" gel effectively reduced systemic side effects in treating colon rectal cancer; however, the penetration efficacy of the formulation was considerably low due to the poor lipid solubility of 5FU. The aim of this study was to develop thermosensitive gel-mediated 5FU water-in-oil microemulsion (TG-5FU-ME) for improving the infiltration of 5FU. An in vitro release test showed that TG-5FU-ME sustained the drug's release up to 10 hours. TG-5FU-ME exhibited good stability, and the microemulsion entrapped did not show any change in morphology and 5FU content during the 4-month storage...
2016: Drug Design, Development and Therapy
Emiliano Felici, Cristian Casado, Chien C Wang, Julio Raba, María R Gomez
Antiparasitic drugs derived from macrocyclic lactones are widely used in livestock activities around the world. An increasing concern for local authorities is the environmental pollution as a consequence of veterinary drugs widely used in rural areas. The purpose of environmental analysis is to monitor low levels of pollutant analytes in a large number of samples. Also, due to the lipophilic characteristic of these lactones, long chain solvents are usually required for performing sample treatment before and during the analysis...
September 20, 2016: Electrophoresis
Amnon C Sintov, Giora Enden
The purpose of this study was to investigate a new polymeric system and production process in which self-assembled doxorubicin-loaded nanoparticles were synthetized by using a water-in-oil microemulsion as a template and calcium ions as cross-linkers. The manufacturing process combined cross-linking of carbomer within a W/O microemulsion followed by a phase-separation technique to avoid using organic solvents for extraction. To assess the sustained release behavior of doxorubicin from the nanoparticles, we have developed a new simple method based on the permeability coefficient of a synthetic membrane mounted on Franz diffusion cell system...
October 6, 2016: Drug Development and Industrial Pharmacy
Gerhard K E Scriba, Henrik Harnisch, Qingfu Zhu
Capillary electrophoresis (CE) is a versatile and flexible technique for analytical enantioseparations. This is due to the large variety of chiral selectors as well as the different operation modes including electrokinetic chromatography, micellar electrokinetic chromatography, and microemulsion electrokinetic chromatography. The chiral selector, which is added to the background electrolyte, represents a pseudostationary phase with its own electrophoretic mobility allowing a variety of different separation protocols...
2016: Methods in Molecular Biology
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