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https://www.readbyqxmd.com/read/28812284/new-nanocomposites-of-polystyrene-with-polyaniline-doped-with-lauryl-sulfuric-acid
#1
A A Pud, O A Nikolayeva, L O Vretik, Yu V Noskov, N A Ogurtsov, O S Kruglyak, E A Fedorenko
This work is concentrated on synthesis and investigation of new core-shell nanocomposites of polystyrene (PS) with doped polyaniline (PANI). The latex containing PS nanoparticles with sizes of 15-30 nm was prepared by microemulsion polymerization of styrene in water media. The PS/PANI nanocomposites were synthesized by chemical oxidative polymerization of aniline in the PS latex media in a presence of lauryl sulfuric acid (LSA), which served as both dopant and plasticizer. The real content of PANI in the synthesized nanocomposites was determined by UV-Vis spectroscopy method...
August 15, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28806653/novel-microemulsion-based-gels-for-topical-delivery-of-indomethacin-formulation-physicochemical-properties-and-in-vitro-drug-release-studies
#2
Anna Froelich, Tomasz Osmałek, Agnieszka Snela, Paweł Kunstman, Barbara Jadach, Marta Olejniczak, Grzegorz Roszak, Wojciech Białas
HYPOTHESIS: Microemulsion-based semisolid systems may be considered as an interesting alternative to the traditional dosage forms applied in topical drug delivery. Mechanical properties of topical products are important both in terms of application and dosage form effectiveness. In this study we designed and evaluated novel microemulsion-based gels with indomethacin and analyzed the factors affecting their mechanical characteristics and drug release. EXPERIMENTS: The impact of the microemulsion composition on the extent of isotropic region was investigated with the use of pseudoternary phase diagrams...
August 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28780230/self-assembly-phase-behaviour-and-structural-behaviour-as-observed-by-scattering-for-classical-and-non-classical-microemulsions
#3
REVIEW
Sylvain Prévost, Michael Gradzielski, Thomas Zemb
In this review, we discuss the conditions for forming microemulsions, systems which are thermodynamically stable mixtures of oil and water made stable by the presence of an interfacial film containing surface active molecules. There are several types of microemulsions, depending largely on the stiffness of the amphiphilic monolayer that separates the oily and the aqueous micro-domain. We first discuss and compare the phase behaviour of these different types, starting from the classical microemulsion made from a flexible surfactant film but then also moving on to less classical situations: this occurs when the interfacial film is stiff or when microemulsions are formed in the absence of a classical surfactant...
July 18, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28777632/streaming-from-the-equator-of-a-drop-in-an-external-electric-field
#4
Quentin Brosseau, Petia M Vlahovska
Tip streaming generates micron- and submicron-sized droplets when a thin thread pulled from the pointy end of a drop disintegrates. Here, we report streaming from the equator of a drop placed in a uniform electric field. The instability generates concentric fluid rings encircling the drop, which break up to form an array of microdroplets in the equatorial plane. We show that the streaming results from an interfacial instability at the stagnation line of the electrohydrodynamic flow, which creates a sharp edge...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28773882/nonionic-microemulsions-as-solubilizers-of-hydrophobic-drugs-solubilization-of-paclitaxel
#5
Jen-Ting Lo, Tzer-Min Lee, Bing-Hung Chen
The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37 °C. Briefly, the suitable oil phase with paclitaxel significantly dissolved is microemulsified with appropriate surfactants...
September 7, 2016: Materials
https://www.readbyqxmd.com/read/28772632/kdp-aqueous-solution-in-oil-microemulsion-for-ultra-precision-chemical-mechanical-polishing-of-kdp-crystal
#6
Hui Dong, Lili Wang, Wei Gao, Xiaoyuan Li, Chao Wang, Fang Ji, Jinlong Pan, Baorui Wang
A novel functional KH₂PO₄ (KDP) aqueous solution-in-oil (KDP aq/O) microemulsion system for KDP crystal ultra-precision chemical-mechanical polishing (CMP) was prepared. The system, which consisted of decanol, Triton X-100, and KH₂PO₄ aqueous solution, was available at room temperature. The functional KDP aq/O microemulsion system was systematically studied and applied as polishing solution to KDP CMP technology. In this study, a controlled deliquescent mechanism was proposed for KDP polishing with the KDP aq/O microemulsion...
March 9, 2017: Materials
https://www.readbyqxmd.com/read/28761831/preparation-and-microstructural-characterization-of-griseofulvin-microemulsions-using-different-experimental-methods-saxs-and-dsc
#7
Eskandar Moghimipour, Anayatollah Salimi, Sahar Changizi
Purpose: The objective of the present study is to formulate and evaluate a new microemulsion (ME) for topical delivery of griseofulvin. Methods: The solubilities of griseofulvin in different combinations of surfactant to co-surfactant (S/Co ratio) were determined. Accordingly, based on their phase diagrams, eight microemulsions were formulated and then evaluated with respect to their particle size, surface tension, viscosity, conductivity, zeta potential and stability. Their release behavior, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), refractory index (RI), pH and Small-angle-X-ray scattering (SAXS) were also assessed...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28760977/molecular-characterization-of-water-and-surfactant-aot-at-nanoemulsion-surfaces
#8
Jennifer K Hensel, Andrew P Carpenter, Regina K Ciszewski, Brandon K Schabes, Clive T Kittredge, Fred G Moore, Geraldine L Richmond
Nanoemulsions and microemulsions are environments where oil and water can be solubilized in one another to provide a unique platform for many different biological and industrial applications. Nanoemulsions, unlike microemulsions, have seen little work done to characterize molecular interactions at their surfaces. This study provides a detailed investigation of the near-surface molecular structure of regular (oil in water) and reverse (water in oil) nanoemulsions stabilized with the surfactant dioctyl sodium sulfosuccinate (AOT)...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28758958/evaluation-of-antioxidant-activity-and-growth-control-properties-of-nonoscale-structure-produced-from-aloe-vera-var-littoralis-extract-on-clinical-isolates-of-salmonella
#9
Reza Ranjbar, Mohammad Arjomandzadegan, Hossein Hosseiny
The aim of the study was to examine antibacterial properties of microemulsion structure produced from Aloe vera var. littoralis extract as a new tool of nanoscale drug-like materials. Aloe vera var. littoralis (A. littoralis) extract was prepared by distillation method. A nonocarrier structure in the microemulsion system was prepared from the extract. Serial concentrations were prepared from 8 mg/mL extract and the nonocarrier containing 0.1 mg/mL pure extract and were evaluated by a disk diffusion method for 35 Salmonella clinical isolates...
July 31, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28757910/curcumin-protects-skin-against-uvb-induced-cytotoxicity-via-the-keap1-nrf2-pathway-the-use-of-a-microemulsion-delivery-system
#10
Maya Ben Yehuda Greenwald, Marina Frušić-Zlotkin, Yoram Soroka, Shmuel Ben Sasson, Ronit Bitton, Havazelet Bianco-Peled, Ron Kohen
Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28751064/structure-interfacial-film-properties-and-thermal-fluctuations-of-microemulsions-as-seen-by-scattering-experiments
#11
REVIEW
Julian Oberdisse, Thomas Hellweg
The physics of microemulsions and in particular Dominique Langevin's contributions to the understanding of microemulsion structure and bending properties using scattering techniques are reviewed. Among the many methods used by her and her co-workers, we particularly emphasize optical techniques and small angle neutron scattering (SANS), but also neutron spin echo spectroscopy (NSE). The review is then extended to more recent studies of properties of microemulsions close to surfaces, using reflectometry and grazing-incidence small angle neutron scattering (GISANS)...
July 16, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28750165/synthesis-and-electrophoretic-concentration-of-cadmium-sulfide-nanoparticles-in-reverse-microemulsions-of-tergitol-np-4-in-n-decane
#12
Aleksei N Kolodin, Vladimir V Tatarchuk, Alexander I Bulavchenko, Evgeniia V Poleeva
The kinetics of thiourea synthesis of CdS nanoparticles (NPs) in reverse microemulsions of Tergitol Np-4/n-decane was studied in the temperature range of 313-333 K by spectrophotometry, photon-correlation spectroscopy, and transmission electron microscopy. The formation of NPs is described by the kinetic model, including two consecutive steps: homogeneous nucleation in a solution as the first step and the autocatalytic growth of NPs due to heterogeneous reaction on a continuously increasing surface as the second step...
August 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28735040/co-encapsulation-of-paclitaxel-and-c6-ceramide-in-tributyrin-containing-nanocarriers-improve-co-localization-in-the-skin-and-potentiate-cytotoxic-effects-in-2d-and-3d-models
#13
Vanessa F M Carvalho, Amanda Migotto, Daniela V Giacone, Débora P de Lemos, Thalita B Zanoni, Silvya S Maria-Engler, Leticia V Costa-Lotufo, Luciana B Lopes
Considering that tumor development is generally multifactorial, therapy with a combination of agents capable of potentiating cytotoxic effects is promising. In this study, we co-encapsulated C6 ceramide (0.35%) and paclitaxel (0.50%) in micro and nanoemulsions containing tributyrin (a butyric acid pro-drug included for potentiation of cytotoxicity), and compared their ability to co-localize the drugs in viable skin layers. The nanoemulsion delivered 2- and 2.4-fold more paclitaxel into viable skin layers of porcine skin in vitro at 4 and 8h post-application than the microemulsion, and 1...
July 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28726368/mussel-inspired-polydopamine-coated-lanthanide-nanoparticles-for-nir-ii-ct-dual-imaging-and-photothermal-therapy
#14
Yu Dai, Dongpeng Yang, Danping Yu, Cong Cao, Qiuhong Wang, Songhai Xie, Liang Shen, Wei Feng, Fuyou Li
Nanomedicine has attracted substantial attention for the accurate diagnosis or treatment of carcinoma in recent years. Nd(3+)-doped lanthanide nanophosphor-based near-infrared-II (NIR-II) optical imaging is widely used for deep penetration tissue imaging while X-ray computed tomography (CT) is well-suited for in vivo imaging. Polymer-coated lanthanide nanophosphors are increasingly used in both diagnostics and therapies for tumor in vivo. However, the biocompatibility of nanocomposites and the efficiency of tumor ablation should be taken into consideration when constructing a nanotheranostic probe...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28723410/innovative-pmdi-formulations-of-spray-dried-nanoparticles-for-efficient-pulmonary-drug-delivery
#15
Hao-Ying Li, En-Yu Xu
For drug delivery to the lungs, the aerodynamic size of drug particles plays a predominant role in determining the sites of deposition in the airway, and the particles with the size less than 2μm are highly expected as they will be preferably delivered to the ideal site of alveolar regions. In this paper, a novel platform technology has been developed, where the water (containing pharmaceutically active agents)-in-oil (w/o) microemulsions were spray-dried to generate nanosized drug particles that were able to be homogeneously dispersed in the propellant to form an exceptionally stable suspensions with no precipitates or flocculates during a long time storage...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28717973/design-and-development-of-repaglinide-microemulsion-gel-for-transdermal-delivery
#16
Ujwala A Shinde, Sheela H Modani, Kavita H Singh
Microemulsion formulation of repaglinide, a BCS class II hypoglycemic agent with limited oral bioavailability, was developed considering its solubility in various oils, surfactants, and cosurfactants. The pseudo-ternary phase diagrams for microemulsion regions were constructed by water titration method at K m 1:1 and characterized for optical birefringence, percentage transmittance, pH, refractive index, globule size, zeta potential, viscosity, drug content, and thermodynamic stability. To enhance the drug permeation and residence time, the optimized microemulsions having mean globule size of 36...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28711712/ex-vivo-and-in-vivo-evaluation-of-microemulsion-based-transdermal-delivery-of-e-coli-specific-t4-bacteriophage-a-rationale-approach-to-treat-bacterial-infection
#17
Vaibhav Rastogi, Pragya Yadav, Anurag Verma, Jayanta K Pandit
This study is focused on the development and evaluation of transdermal delivery of E. coli-specific T4 bacteriophages both ex-vivo and in-vivo using microemulsion as delivery carrier in eradicating the infection caused by E. coli. Microemulsions were prepared by mixing selected oil, surfactants and aqueous phase containing bacteriophages. The formulations were subjected to physicochemical characterization, ex-vivo and in-vivo permeation, stability studies, histological and immunofluorescence examination. The colloidal system exhibits a uniform size distribution, of finite size (150-320nm)...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28711641/tacrolimus-loaded-biocompatible-lecithin-based-microemulsions-with-improved-skin-penetration-structure-characterization-and-in-vitro-in-vivo-performances
#18
Vedrana Savić, Marija Todosijević, Tanja Ilić, Milica Lukić, Evgenia Mitsou, Vassiliki Papadimitriou, Spyridon Avramiotis, Bojan Marković, Nebojša Cekić, Snežana Savić
In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28711220/analysis-of-small-molecule-drugs-excipients-and-counter-ions-in-pharmaceuticals-by-capillary-electromigration-methods-recent-developments
#19
REVIEW
Qingfu Zhu, Gerhard K E Scriba
Capillary electromigration techniques have become important tools for the analysis of pharmaceutical drugs. The present review updates on recent developments of the analysis of small molecule drugs, excipients and counter ions dating between January 2014 and May 2017. Capillary electrophoresis (CE) continues to be a very popular method for the analysis of the active pharmaceutical ingredients and their related substances in pharmaceutical formulations, especially for the determination of the stereoisomeric purity of chiral drugs, which is evidenced by a large number of related literature reported in the reviewed period of time...
June 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28704559/synthesis-cytotoxicity-and-antitumour-mechanism-investigations-of-polyoxometalate-doped-silica-nanospheres-on-breast-cancer-mcf-7-cells
#20
Hongqian Cao, Chunyan Li, Wen Qi, Xiangjun Meng, Rui Tian, Yanfei Qi, Wei Yang, Juan Li
Polyoxometalates (POMs) have shown the potential anti-bacterial, anti-viral and anti-tumor activities. In order to improve their physiological stability and antitumour activity for medical application, K2Na[AsIIIMo6O21(O2CCH2NH3)3]·6H2O doped silica nanospheres (POM@SiO2) with diameters of ~40 nm have been synthesized by the water-in-oil microemulsion method in this study. The obtained spheres were morphologically uniform nanosized and nearly monodispersed in solution. The nanoparticles had high entrapment efficiency, which was upto 46...
2017: PloS One
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