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Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Soraya Ghayempour, Majid Montazer
Encapsulation is the best method to protect the plant extracts against volatility and instability in the presence of air, light, moisture and high temperatures. Nevertheless, application of encapsulated plant extracts on the textiles requires a low-temperature and high rate processing to avoid from breaking or destroying of capsules. The present paper represents application of nanocapsules prepared by ultrasound irradiation assisted W/O/W microemulsion method on the cotton fabric through UV curing method. The surface and structure of nanocapsules and treated cotton fabric using FESEM and FT-IR indicated the spherical nanocapsules with size of 60-80nm stabilized on the fabric surface in a film layer feature...
August 15, 2017: Carbohydrate Polymers
Xia Lv, Tiantian Liu, Huipeng Ma, Yan Tian, Lei Li, Zhen Li, Meng Gao, Jianbin Zhang, Zeyao Tang
Quercetin can bring many benefits to skin based on its various bioactivities. However, the therapeutic effect of quercetin is limited due to the poor water solubility, pH instability, light instability, and skin permeation. The aim of the present work was applying essential oil-based microemulsions to improve the solubility, pH stability, photostability, and skin permeation of quercetin for topical application. Peppermint oil (PO-ME), clove oil (CO-ME), and rosemary oil (RMO-ME) were selected as model essential oils...
May 17, 2017: AAPS PharmSciTech
Arghajit Pyne, Jagannath Kuchlyan, Chiranjit Maiti, Dibakar Dhara, Nilmoni Sarkar
In this article, we have reported the synthesis and physicochemical characterization of a novel L-glycine amino acid derived cholesterol based surface active ionic liquid (SAIL). This SAIL has been explored for the preparation of ionic liquid (IL)-in-oil microemulsions and vesicles. The formation of IL-in-oil microemulsion is characterized by construction of a ternary phase diagram, dynamic light scattering (DLS) measurement, proton nuclear magnetic resonance (1H NMR) study, fluorescence measurement using coumarin 480 (C-480) as a molecular probe and also by recording the diffusion behavior of the molecular probe rhodamine 6G (R6G) in microemulsion droplets through Fluorescence correlation spectroscopy (FCS) technique...
May 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Shailja Kumar, Virendra Kumar Meena, Puja Panwar Hazari, Rakesh Kumar Sharma
We report water-in-oil microemulsion mediated synthesis of polyethylene glycol (PEG(1)) coated Gd2O3 nanoparticles (NPs(2)) loaded with fluorescent anti-cancer drug doxorubicin (dox(3)) for synchronous drug delivery, optical and magnetic resonance (MR(4)) imaging applications. These PEG covered Gd2O3 NPs loaded with dox (Gd-PEG-dox NPs) were found to possess spherical morphology with 13nm size as measured from TEM and the hydrodynamic diameter comes out to be 37nm as determined from DLS. Fluorescence spectra and fluorescence microscopy images confirmed optical activity of the NPs...
May 12, 2017: International Journal of Pharmaceutics
Bhagyashree Chaudhari, Swati Jagdale
BACKGROUND: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which causes inflammation. Triamcinolone has half-life of 88 minutes. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life. OBJECTIVE: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone...
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
Shannon P Callender, Jessica A Mathews, Katherine Kobernyk, Shawn D Wettig
Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form spontaneously upon mixing of oil, water and emulsifier. This review is the first to address advantages and disadvantages, as well as considerations and challenges in multi-drug delivery. For the period 1 January 2011-30 April 2016, 431 publications related to microemulsion drug delivery were identified and screened according to microemulsion, drug classification, and surfactant types...
May 7, 2017: International Journal of Pharmaceutics
Shiva Golmohammadzadeh, Nafiseh Farhadian, Amir Biriaee, Faranak Dehghani, Bahman Khameneh
Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator which is orally used for treatment of osteoporosis and prevention of breast cancer. The drug has low aqueous solubility and bioavailability. The aim of the present study is to formulate and characterize oil-in-water microemulsion systems for oral delivery of RLX. To enhance the drug aqueous solubility, microemulsion based on sesame oil was prepared. Sesame oil and Tween 80 were selected as the drug solvent oil and surfactant, respectively...
May 10, 2017: Drug Development and Industrial Pharmacy
Xiao Tang, Elvira Kröger, Andreas Nielsen, Christian Strelow, Alf Mews, Tobias Kipp
Microemulsion (water-in-oil) methods enable the encapsulation of individual nanoparticles into SiO2 spheres. The major drawbacks of this method, when applied for silica encapsulation of anisotropic nanorods (NRs), are a spatially unequal silica growth and long reaction times (24 h at least). In this work, various tetra-alkoxysilanes (tetramethyl orthosilicate (TMOS), tetraethyl orthosilicate (TEOS) and tetrapropyl orthosilicate (TPOS)) with different alkyl-chain lengths were used as the silica precursors in attempt to tune the silanization behavior of CdSe/CdS NRs in a microemulsion system...
May 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Husain N Kagalwala, Danielle N Chirdon, Isaac N Mills, Nikita Budwal, Stefan Bernhard
A unique microemulsion-based photocatalytic water reduction system is demonstrated. Iridium- and rhodium-based metallosurfactants, namely, [Ir(ppy)2(dhpdbpy)]Cl and [Rh(dhpdbpy)2Cl2]Cl (where ppy = 2-phenylpyridine and dhpdbpy = 4,4'-diheptadecyl-2,2'-bipyridine), were employed as photosensitizer and proton reducing catalyst, respectively, along with oxalic acid as a sacrificial reductant in a toluene/water biphasic mixture. The addition of 1-octylamine is proposed to initiate the reaction, by coupling with oxalic acid to form an ion pair, which acts as an additional surfactant...
May 10, 2017: Inorganic Chemistry
Rania Yehia, Rania M Hathout, Dalia A Attia, Mohamed M Elmazar, Nahed D Mortada
Targeting solid tumors transdermally is an emerging approach that is currently under intense investigation. In this context, microemulsions are reported as one of the most favored carriers for successful transdermal drug delivery. Thereby, these nano-carriers were utilized in this study for the delivery of a phytochemical, namely methyl dihydrojasmonate (MDHJ), which has previously demonstrated an anticancer effect. Accordingly, pseudoternary phase diagrams were constructed using several combinations of oils, surfactants and co-surfactants and following the water titration method...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
Diego R Perinelli, Marco Cespi, Stefania Pucciarelli, Silvia Vincenzetti, Luca Casettari, Jenny K W Lam, Serena Logrippo, Elisa Canala, Mahmoud E Soliman, Giulia Bonacucina, Giovanni F Palmieri
BACKGROUND: Microemulsions are attractive delivery systems for therapeutic proteins and peptides due to their ability to enhance bioavailability. Although different proteins and peptides have been successfully delivered through such ternary systems, no information can be found about protein loading and the formulation stability when such microemulsions are prepared with pharmaceutically-approved oils and surfactants. The aim of this work was to optimise a ternary system consisting of water/ethyl oleate/Span 80-Tween 80 and to determine its protein loading capacity and stability, using bovine serum albumin (BSA) as a model of biomolecule...
May 7, 2017: Current Pharmaceutical Biotechnology
Maria D Chatzidaki, Konstantinos D Papavasileiou, Manthos G Papadopoulos, Aristotelis Xenakis
Water-in-oil microemulsions with biocompatible components were formulated to be used as carriers of natural antioxidants, such as hydroxytyrosol (HT) and gallic acid (GA). The system was composed of a mixture of natural surfactants, lecithin and monoglycerides, medium chain triglycerides, and aqueous phase. A dual approach was undertaken to study the structure and dynamics of these complicated systems. First, experimental data were collected by using adequate techniques, such as dynamic light scattering (DLS) and electron paramagnetic resonance (EPR) spectroscopy...
May 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Dongfang Liu, Yuxin Suo, Jiang Tan, Hongsheng Lu
At present, more and more researchers around the world are paying attention to stimuli-responsive surfactants. In this paper, we have reported a microemulsion prepared from the tertiary amine TMPDA (N,N,N',N'-tetramethyl-1,3-propanediamine) and the anionic surfactant SDS (sodium dodecyl sulphate), which has good carbon dioxide response characteristics. The molar ratio of TMPDA to SDS is 1 : 2. By introducing CO2 into the microemulsion that consists of SDS, TMPDA, n-hexane, n-butanol and water, the tertiary amine TMPDA molecules can be protonated to form quaternary ammonium species...
May 24, 2017: Soft Matter
Jing Chen, Yanping He, Ting Gao, Licheng Zhang, Yuna Zhao
BACKGROUND: Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound Arnebiae radix microemulsion gel for transdermal delivery system and evaluate its characteristics. MATERIALS AND METHODS: Based on the solubility of Shikonin, the active component of Arnebiae radix and the results of phase studies, adequate ratio of each component in microemulsion was determined...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Xiaojian Li, Yaoguang Wang, Li Shi, Hongmin Ma, Yong Zhang, Bin Du, Dan Wu, Qin Wei
An electrochemiluminescence (ECL) biosensor was developed for detection of Concanavalin A (Con A). Chitosan/Ru(bpy)3(2+)/silica/Fe3O4 nanomaterials (CRuSi-Fe3O4) were synthesized through W/O microemulsion route. The added Fe3O4 nanoparticles can simplify the prepared process and enhance the conductivity of nanomaterials which can increase the ECL intensity of luminophor CRuSi-Fe3O4. In addition, the layered structure of CRuSi-Fe3O4 can immobilize lots of Con A using glutaraldehyde as the coupling agent which can improve the sensitivity of the biosensor...
May 1, 2017: Biosensors & Bioelectronics
M A Motaleb, I T Ibrahim, M E Sayyed, G A S Awad
OBJECTIVES: The preparation of (131)I-trazodone hydrochloride and its biological evaluation as a promising brain imaging radiopharmaceutical using two routes of administration. MATERIAL AND METHODS: Trazodone (TZ) was radiolabelled with (131)I using direct electrophilic substitution, and different factors affecting labelling yield were studied. Quality control of (131)I-TZ was carried out using ascending paper chromatography, paper electrophoresis, and high pressure liquid chromatography (HPLC)...
April 27, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
Xu Li, Youssef W Naguib, Zhengrong Cui
Bisphosphonates are used to treat bone diseases such as osteoporosis and cancer-induced bone pain and fractures. It is thought that modifying the pharmacokinetics and biodistribution profiles of bisphosphonates (i.e. rapid renal clearance and extensive bone absorption) will not only reduce their side effects, but also expand their clinical applications to extraskeletal tissues. In the present work, using zoledronic acid (Zol) and calcium as model bisphosphonate and metal molecules, respectively, we prepared DOPA (an anionic lipid)-coated spherical Zol-Ca nanocomposites (Zol-Ca@DOPA) and developed Zol-nanoparticle formulations (i...
April 26, 2017: International Journal of Pharmaceutics
Zhaoxiong Yan, Zhihua Xu, Jiaguo Yu, Mietek Jaroniec
A series of Au/AlOOH catalysts was prepared by impregnating different AlOOH supports with Au precursor followed by NaBH4-assisted reduction, and examined their activity toward oxidation of indoor formaldehyde (HCHO) pollutant at room temperature. The AlOOH supports used were synthesized by microemulsion, microwave and hydrothermal methods. Among these supports the catalyst obtained by deposition of Au nanoparticles (NPs) on AlOOH prepared by microemulsion method (Au/AlOOH-m) exhibited the highest catalytic activity...
April 19, 2017: Journal of Colloid and Interface Science
Benoit Richard, Jean-Luc Lemyre, Anna M Ritcey
Quasi-monodisperse populations of (H3O)Y3F10·xH2O nanocrystals of varying size are prepared in Igepal-stabilized microemulsions. Correlations between microemulsion composition, micelle hydrodynamic radius, and final nanoparticle size are established and shed light on the mechanism of particle size control. Under the conditions considered here, size control appears to be primarily governed by the number of micelles and the quantities of precursor ions. More specifically, the number of NPs formed can be successfully correlated with the number of micelles present and final NP size is, in turn, determined by the number of nuclei and the total amount of material available for nanocrystal formation...
May 2, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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