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https://www.readbyqxmd.com/read/29327154/effect-of-synthesis-method-of-la1%C3%A2-%C3%A2-xsr-x-mno3-manganite-nanoparticles-on-their-properties
#1
Yulia Shlapa, Sergii Solopan, Anatolii Belous, Alexandr Tovstolytkin
Nanoparticles of lanthanum-strontium manganite were synthesized via different methods, namely, sol-gel method, precipitation from non-aqueous solution, and precipitation from reversal microemulsions. It was shown that the use of organic compounds and non-aqueous media allowed significantly decreasing of the crystallization temperature of nanoparticles, and the single-phased crystalline product was formed in one stage. Morphology and properties of nanoparticles depended on the method and conditions of the synthesis...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29318975/evaluation-of-the-antiproliferative-activity-of-some-nanoparticulate-essential-oils-formulated-in-microemulsion-on-selected-human-carcinoma-cell-lines
#2
Ahmed Abd-Rabou, Amr E Edris
BACKGROUND: Essential oils (EOs) are natural volatile plant extract that have different biological activities including antiproliferative potentials. OBJECTIVE: the current study aims at evaluating the antiproliferative activities of six EOs in their neat state compared to their nanoparticulate form after fabrication in microemulsion against some cancer cell lines. The EOs included marjoram (Origanum majorana), turmeric (Curcuma longa), sweet basil (Ocimum basillicum), clove buds (Syzygium aromaticum), geranium (plargonium graviolenis), and black cumin (Nigella sativa)...
January 10, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29316822/beneficial-anti-inflammatory-effect-of-paeonol-self-microemulsion-loaded-colon-specific-capsules-on-experimental-ulcerative-colitis-rats
#3
Shiyu Zong, Yiqiong Pu, Suyun Li, Benliang Xu, Yong Zhang, Tong Zhang, Bing Wang
Paeonol, as the main phenolic compound isolated from the Chinese herbs, has been confirmed to present anti-inflammatory effects on ulcerative colitis (UC) in our previous study. However, its poor solubility has hindered its development of being a favourable pharmaceutical product in treating colon diseases. In this study, we prepared the colon-specific delivery system (Pae-SME-CSC) with paeonol-loaded self-microemulsion (Pae-SMEDDS), and evaluated its in vitro and in vivo properties, especially the anti-inflammatory effects on UC rats...
January 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29310094/silver-poly-vinyl-alcohol-nanocomposite-film-prepared-using-water-in-oil-microemulsion-for-antibacterial-applications
#4
Ummul K Fatema, M Muhibur Rahman, M Rakibul Islam, M Yousuf A Mollah, Md Abu Bin Hasan Susan
HYPOTHESIS: Water in oil microemulsion (w/o) is a simple preparative route for nanoparticles where water droplets (dispersed in continuous oil medium and stabilized by surfactants and cosurfactants) act as nanoreactors to carry out chemical reactions. If polymeric matrix is incorporated inside the core of the microemulsions, it should prevent the agglomeration of nanoparticles after separation from microemulsions. Thus polymer nanocomposite films prepared from w/o microemulsions are expected to give narrow and homogeneous size distribution of nanoparticles throughout the polymer host...
December 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29307286/microemulsion-based-delivery-of-triamcinolone-acetonide-to-posterior-segment-of-eye-using-chitosan-and-butter-oil-as-permeation-enhancer-an-in-vitro-and-in-vivo-investigation
#5
Nidhi Raval, Dignesh Khunt, Manju Misra
The aim of the study was to formulate a microemulsion (ME) using chitosan (CH) and the Butter oil (BO) as a permeation enhancer for targeting drug to the posterior segment of the eye, via topical route. Triamcinolone acetonide (TA) was selected as the model drug since it undergoes extensive first-pass metabolism leading to poor oral bioavailability of 23%. For optimization of BO concentration, different ratios of TA:BO were prepared by simple physical mixing in the ratio of 1:9 to 9:1 and diffusion study was performed...
January 8, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29301523/genoprotective-antioxidant-antifungal-and-anti-inflammatory-evaluation-of-hydroalcoholic-extract-of-wild-growing-juniperus-communis-l-cupressaceae-native-to-romanian-southern-sub-carpathian-hills
#6
Irina Fierascu, Camelia Ungureanu, Sorin Marius Avramescu, Carmen Cimpeanu, Mihaela Ioana Georgescu, Radu Claudiu Fierascu, Alina Ortan, Anca Nicoleta Sutan, Valentina Anuta, Anca Zanfirescu, Cristina Elena Dinu-Pirvu, Bruno Stefan Velescu
BACKGROUND: Juniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills. METHODS: The prepared hydroethanolic extract of Juniperus communis L...
January 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29299992/development-of-a-nasal-donepezil-loaded-microemulsion-for-treatment-of-alzheimer-s-disease-in-vitro-and-ex-vivo-characterization
#7
Lupe Carolina Espinoza, Marisol Vacacela, Beatriz Clares, Maria Luisa Garcia, Maria Jose Fabrega, Ana Cristina Calpena
BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer's disease (AD). OBJECTIVE: Considering the therapeutic potential of DPZ and the advantages offered by the intranasal route as an alternative for drug administration, the aim of this study was the development and characterization of a DPZ microemulsion (ME) for nose-to-brain delivery. METHOD: The ME was developed by construction of pseudoternary phase diagrams and characterized by dynamic light scattering and transmission electron microscopy...
January 4, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29296084/development-and-characterization-of-p1025-loaded-bioadhesive-liquid-crystalline-system-for-the-prevention-of-streptococcus-mutans-biofilms
#8
Giovana Maria Fioramonti Calixto, Cristiane Duque, Kelly Limi Aida, Vanessa Rodrigues Dos Santos, Loiane Massunari, Marlus Chorilli
Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, analogous to the fragments 1025-1044 of S. mutans cellular adhesin, responsible for the adhesion and formation of dental biofilm. However, peptides have physicochemical characteristics that may affect their biological action, limiting their clinical performance. Therefore, drug-delivery systems, such as a bioadhesive liquid-crystalline system (LCS), may be attractive strategies for peptide delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29286161/astilbin-emulsion-improves-guinea-pig-lesions-in-a-psoriasis-like-model-by-suppressing-il-6-and-il-22-via-p38-mapk
#9
Jinghong Yu, Zhicai Xiao, Ruizhi Zhao, Chuanjian Lu, Yuemei Zhang
Astilbin has anti-inflammatory and immunoregulatory effects, and is frequently used in prescriptions treating psoriasis; however, the mechanism remains to be fully elucidated. In the present study, the effect of an astilbin microemulsion on a psoriasis‑like model in guinea pigs was examined, and the underlying mechanism was investigated. The levels of interkeukin (IL)‑6, IL‑17A and IL‑22 were determined using fluorescent reverse transcription‑quantitative polymerase chain reaction analysis and enzyme‑linked immunosorbent assays...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29282555/green-adeptness-in-the-synthesis-and-stabilization-of-copper-nanoparticles-catalytic-antibacterial-cytotoxicity-and-antioxidant-activities
#10
REVIEW
Muhammad Imran Din, Farhan Arshad, Zaib Hussain, Maria Mukhtar
Copper nanoparticles (CuNPs) are of great interest due to their extraordinary properties such as high surface-to-volume ratio, high yield strength, ductility, hardness, flexibility, and rigidity. CuNPs show catalytic, antibacterial, antioxidant, and antifungal activities along with cytotoxicity and anticancer properties in many different applications. Many physical and chemical methods have been used to synthesize nanoparticles including laser ablation, microwave-assisted process, sol-gel, co-precipitation, pulsed wire discharge, vacuum vapor deposition, high-energy irradiation, lithography, mechanical milling, photochemical reduction, electrochemistry, electrospray synthesis, hydrothermal reaction, microemulsion, and chemical reduction...
December 28, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29277010/ferritin-based-bionanocages-as-novel-biomemory-device-concept
#11
Şükriye Nihan Karuk Elmas, Remziye Güzel, Mehmet Girayhan Say, Arzu Ersoz, Rıdvan Say
Ferritin is an iron cage having protein, capable of extracting metal ions in their cages and a consequence of the electron transfer of metal ions in their cage by reduction and oxidation processes, electrochemical information storage devices can be designed. In this work, ferritin based protein biomemory substrate has been synthesized by using Amino Acid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method, which utilizes photosensitive electron transfer based microemulsion co-polymerization as nanobead form of ferritin...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29276082/anisotropic-reversed-micelles-with-fluorocarbon-hydrocarbon-hybrid-surfactants-in-supercritical-co2
#12
Masanobu Sagisaka, Shinji Ono, Craig James, Atsushi Yoshizawa, Azmi Mohamed, Frédéric Guittard, Robert M Enick, Sarah E Rogers, Adam Czajka, Christopher Hill, Julian Eastoe
Previous work (M. Sagisaka, et al. Langmuir 31 (2015) 7479-7487), showed the most effective fluorocarbon (FC) and hydrocarbon (HC) chain lengths in the hybrid surfactants FCm-HCn (sodium 1-oxo-1-[4-(perfluoroalkyl)phenyl]alkane-2-sulfonates, where m = FC length and n = HC length) were m and n = 6 and 4 for water solubilization, whereas m 6 and n 6, or m 6 and n 5, were optimal chain lengths for reversed micelle elongation in supercritical CO2. To clarify why this difference of only a few methylene chain units is so effective at tuning the solubilizing power and reversed micelle morphology, nanostructures of water-in-CO2 (W/CO2) microemulsions were investigated by high-pressure small-angle neutron scattering (SANS) measurements at different water-to-surfactant molar ratios (W0) and surfactant concentrations...
December 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29260178/highly-luminescent-eu-sm-mn-doped-cas-up-down-conversion-nano-particles-application-to-ultra-sensitive-latent-fingerprint-detection-and-in-vivo-bioimaging
#13
Jikai Wang, Ni He, Yanli Zhu, Zhengbin An, Ping Chen, Craig A Grimes, Zhou Nie, Qingyun Cai
Due to their unique properties, rare-earth doped upconversion luminescence (UCL) nanomaterials are of considerable scientific interest. Meanwhile, alkaline-earth sulfide materials based on a completely different electron trapping (ET) mechanism demonstrate extremely high UCL efficiencies, which are several dozens of times more than those of conventional fluoride UCL nanomaterials. However, the large particle size, easy hydrolysis, and difficulty in achieving uniform dispersion have precluded bioassay applications...
December 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29258246/microemulsion-and-sol-gel-synthesized-zro%C3%A2-mgo-catalysts-for-the-liquid-phase-dehydration-of-xylose-to-furfural
#14
Almudena Parejas, Vicente Montes, Jesús Hidalgo-Carrillo, Elena Sánchez-López, Alberto Marinas, Francisco J Urbano
Two series of catalysts were prepared by sol-gel and microemulsion synthetic procedure (SG and ME, respectively). Each series includes both pure Mg and Zr solids as well as Mg-Zr mixed solids with 25%, 50% and 75% nominal Zr content. The whole set of catalysts was characterized from thermal, structural and surface chemical points of view and subsequently applied to the liquid-phase xylose dehydration to furfural. Reactions were carried out in either a high-pressure autoclave or in an atmospheric pressure multi-reactor under a biphasic (organic/water) reaction mixture...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29247704/increased-anti-biofilm-efficacy-of-toluidine-blue-on-staphylococcus-species-after-nano-encapsulation
#15
Bishakh Rout, Chi-Hsien Liu, Wei-Chi Wu
BACKGROUND: Photodynamic therapy has been studied by many studies as a method for inactivating bacterial growth. Workers have used planktonic bacterial as well as biofilm bacterial cultures to evaluate the potential of photodynamic therapy in inactivating bacteria. However, almost all the studies use a photosensitiser in aqueous solution, which could be detrimental to the efficiency of photodynamic therapy. METHODS: In this study, the photodynamic killing effect of toluidine blue O (TBO) has been investigated on Staphylococcal biofilms in -vitro...
December 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29247690/dermal-peptide-delivery-using-enhancer-moleculs-and-colloidal-carrier-systems-part-ii-tetrapeptide-pkek
#16
Reinhard H H Neubert, Elfi Sommer, Melanie Schölzel, Benjamin Tuchscherer, Yahja Mrestani, Johannes Wohlrab
Due to the lipophilic properties of the uppermost skin layer of the stratum corneum (SC) it is highly challenging to reach therapeutic concentrations of cosmetic actives and drugs. Particularly, the hydrophilic ones penetrate poorly across the SC. The purpose of this study was to improve the topical bioavailability of the hydrophilic, polar tetrapeptide PKEK (amino acid sequence in one-letter notation). A nano-sized carrier system (microemulsion, ME) was therefore developed since MEs provide excellent penetration enhancing properties...
December 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29245075/evidence-of-coexisting-microemulsion-droplets-in-oil-in-water-emulsions-revealed-by-2d-dosy-1h-nmr
#17
Tarek S Awad, Dalal Asker, Laurence S Romsted
Optimizing the macroscopic properties, shelf-life and stability of emulsion products requires a better understanding of the microstructural characteristics such as the type (nano, micro and macro) and the relative distribution of components (i.e., oil and surfactant) within the emulsion droplets. We used Diffusion-Ordered NMR Spectroscopy (DOSY NMR) to evaluate these characteristics in model oil-in-water emulsion containing Tween 80 and medium chain triglycerides (MCT). At low MCT concentrations, the solutions were transparent but from 1 to 5 wt% MCT, they became translucent then opaque...
December 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29243576/a-novel-polymer-lipid-hybrid-nanoparticle-for-the-improvement-of-topotecan-hydrochloride-physicochemical-properties
#18
Emanuelle Jesus Silva, Leonardo Gomes Souza, Luis Antonio Dantas Silva, Stephania Fleury Taveira, Raquel Ciffarello Guilger, Luciano Morais Liao, Luiz Henrique Keng Queiroz Junior, Mabio Joao Santana, Ricardo Neves Marreto
BACKGROUND: Topotecan (TPT) is a water-soluble derivate of camptothecin, which undergoes ring-opening hydrolysis in neutral solutions, leading to stability loss and poor cellular uptake. Lipid nanoencapsulation can improve TPT stability, and polymer-lipid hybrid nanoparticles (PLN) are interesting alternatives to improve TPT nanoencapsulation. OBJECTIVE: This study seeks to prepare complexes between the cationic TPT and the negatively charged dextran sulfate (DS) with a view of improving drug loading, chemical stability and release control...
December 14, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29224625/peroxidase-chemically-attached-on-polymeric-micelle-and-its-reaction-with-phenolic-compounds
#19
Moo-Yeal Lee, Parnian Bigdelou, Kyung-Jin Hong, Kyoung-Ae Kim, Yoshitsune Shinya, Toshio Kajiuchi
Horseradish peroxidase was chemically modified with comb-shaped polymaleic anhydride-alt-1-tetradecene (PMA-TD) in microemulsion systems to produce surface-active peroxidase that has capability to form micellar structures in aqueous solutions and can be concentrated at liquid/liquid interfaces without unfolding of the enzyme. For chemical modification oil-in-water (O/W) and water-in-oil (W/O) microemulsion systems composed of n-butyl acetate and a buffer solution were prepared because n-butyl acetate turned out to be less detrimental to the activity of peroxidase at high degree of modification compared to other organic solvents...
February 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29222025/preparation-and-comparison-of-tacrolimus-loaded-solid-dispersion-and-self-microemulsifying-drug-delivery-system-by-in-vitro-in-vivo-evaluation
#20
Taotao Huo, Chun Tao, Minxin Zhang, Qinghong Liu, Bing Lin, Zhihong Liu, Jialiang Zhang, Meijing Zhang, Haiyue Yang, Jue Wu, Xinrong Sun, Qian Zhang, Hongtao Song
This study aimed to compare the dissolution and the intestinal absorption of tacrolimus in self-microemulsifying drug delivery system (SMEDDS) and solid dispersion (SD). Poloxamer 188 SD was prepared by the combination of the solvent evaporation method and the freeze drying method. Hydroxypropyl methylcellulose (HPMC) SD was prepared by the solvent evaporation method combined with the vacuum drying method. The formation of SD was confirmed by SEM images which showed new solid phases. The SMEDDS was composed of oil (Labrafil M1944 CS 28%), surfactant (Cremophor EL 48%) and co-surfactant (Transcutol P 24%)...
December 5, 2017: European Journal of Pharmaceutical Sciences
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