keyword
MENU ▼
Read by QxMD icon Read
search

microemulsion

keyword
https://www.readbyqxmd.com/read/28726368/mussel-inspired-polydopamine-coated-lanthanide-nanoparticles-for-nir-ii-ct-dual-imaging-and-photothermal-therapy
#1
Yu Dai, Dongpeng Yang, Danping Yu, Cong Cao, Qiuhong Wang, Songhai Xie, Liang Shen, Wei Feng, Fuyou Li
Nanomedicine has attracted substantial attentions for accurate diagnosis or treatment of carcinoma in recent years. Nd3+ doped lanthanide nanophosphors based near-infrared-II (NIR-II) optical imaging is widely used for deep penetration tissue imaging while X-ray computed tomography (CT) is well-suited for in vivo imaging. Polymer coated lanthanide nanophosphors were increasingly used as both diagnostics and therapies for tumor in vivo. However, the bio-compatibility of nanocomposites and efficiency of tumor ablation should be taken into consideration when construct of a nanotheranostic probe...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28723410/innovative-pmdi-formulations-of-spray-dried-nanoparticles-for-efficient-pulmonary-drug-delivery
#2
Hao-Ying Li, En-Yu Xu
For drug delivery to the lungs, the aerodynamic size of drug particles plays a predominant role in determining the sites of deposition in the airway, and the particles with the size less than 2 microns are highly expected as they will be preferably delivered to the ideal site of alveolar regions. In this paper, a novel platform technology has been developed, where the water (containing pharmaceutically active agents)-in-oil (w/o) microemulsions were spray-dried to generate nanosized drug particles that were able to be homogeneously dispersed in the propellant to form an exceptionally stable suspensions with no precipitates or flocculates during a long time storage...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28717973/design-and-development-of-repaglinide-microemulsion-gel-for-transdermal-delivery
#3
Ujwala A Shinde, Sheela H Modani, Kavita H Singh
Microemulsion formulation of repaglinide, a BCS class II hypoglycemic agent with limited oral bioavailability, was developed considering its solubility in various oils, surfactants, and cosurfactants. The pseudo-ternary phase diagrams for microemulsion regions were constructed by water titration method at K m 1:1 and characterized for optical birefringence, percentage transmittance, pH, refractive index, globule size, zeta potential, viscosity, drug content, and thermodynamic stability. To enhance the drug permeation and residence time, the optimized microemulsions having mean globule size of 36...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28711712/ex-vivo-and-in-vivo-evaluation-of-microemulsion-based-transdermal-delivery-of-e-coli-specific-t4-bacteriophage-a-rationale-approach-to-treat-bacterial-infection
#4
Vaibhav Rastogi, Pragya Yadav, Anurag Verma, Jayanta K Pandit
This study is focused on the development and evaluation of transdermal delivery of E. coli-specific T4 bacteriophages both ex-vivo and in-vivo using microemulsion as delivery carrier in eradicating the infection caused by E. coli. Microemulsions were prepared by mixing selected oil, surfactants and aqueous phase containing bacteriophages. The formulations were subjected to physicochemical characterization, ex-vivo and in-vivo permeation, stability studies, histological and immunofluorescence examination. The colloidal system exhibits a uniform size distribution, of finite size (150-320nm)...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28711641/tacrolimus-loaded-biocompatible-lecithin-based-microemulsions-with-improved-skin-penetration-structure-characterization-and-in-vitro-in-vivo-performances
#5
Vedrana Savić, Marija Todosijević, Tanja Ilić, Milica Lukić, Evgenia Mitsou, Vassiliki Papadimitriou, Spyridon Avramiotis, Bojan Marković, Nebojša Cekić, Snežana Savić
In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28711220/analysis-of-small-molecule-drugs-excipients-and-counter-ions-in-pharmaceuticals-by-capillary-electromigration-methods-recent-developments
#6
REVIEW
Qingfu Zhu, Gerhard K E Scriba
Capillary electromigration techniques have become important tools for the analysis of pharmaceutical drugs. The present review updates on recent developments of the analysis of small molecule drugs, excipients and counter ions dating between January 2014 and May 2017. Capillary electrophoresis (CE) continues to be a very popular method for the analysis of the active pharmaceutical ingredients and their related substances in pharmaceutical formulations, especially for the determination of the stereoisomeric purity of chiral drugs, which is evidenced by a large number of related literature reported in the reviewed period of time...
June 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28704559/synthesis-cytotoxicity-and-antitumour-mechanism-investigations-of-polyoxometalate-doped-silica-nanospheres-on-breast-cancer-mcf-7-cells
#7
Hongqian Cao, Chunyan Li, Wen Qi, Xiangjun Meng, Rui Tian, Yanfei Qi, Wei Yang, Juan Li
Polyoxometalates (POMs) have shown the potential anti-bacterial, anti-viral and anti-tumor activities. In order to improve their physiological stability and antitumour activity for medical application, K2Na[AsIIIMo6O21(O2CCH2NH3)3]·6H2O doped silica nanospheres (POM@SiO2) with diameters of ~40 nm have been synthesized by the water-in-oil microemulsion method in this study. The obtained spheres were morphologically uniform nanosized and nearly monodispersed in solution. The nanoparticles had high entrapment efficiency, which was upto 46...
2017: PloS One
https://www.readbyqxmd.com/read/28699755/co2-reactive-ionic-liquid-surfactants-for-the-control-of-colloidal-morphology
#8
Paul Brown, Vishnu Sresht, Huseyin Burak Eral, Andrew Fiore, César de la Fuente-Núñez, Marcus O'Mahony, Gabriel P Mendes, William T Heller, Patrick S Doyle, Daniel Blankschtein, T Alan Hatton
This paper reports on a new class of stimuli-responsive surfactant generated from commercially available amphiphiles such as dodecyltrimethylammmonium bromide (DTAB) by substitution of the halide counterion with counterions such as 2-cyanopyrrolide, 1,2,3-triazolide, and L-proline that complex reversibly with CO2. Through a combination of small-angle neutron scattering (SANS), electrical conductivity measurements, thermal gravimetric analysis, and molecular dynamics simulations, we show how small changes in charge reorganization and counterion shape and size induced by complexation with CO2 allow for fine tunability of surfactant properties...
July 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28694660/solid-lipid-nanoparticles-delivering-anti-inflammatory-drugs-to-treat-inflammatory-bowel-disease-effects-in-an-in-vivo-model
#9
Chiara Dianzani, Federica Foglietta, Benedetta Ferrara, Arianna Carolina Rosa, Elisabetta Muntoni, Paolo Gasco, Carlo Della Pepa, Roberto Canaparo, Loredana Serpe
AIM: To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS: Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanoformulation has been investigated in vitro (cell adhesion to human vascular endothelial cells and pro-inflammatory cytokine release by lipopolysaccharide-induced polymorphonuclear cells) and in vivo (disease activity index and cytokine plasma concentrations in a dextran sulfate sodium-induced mouse colitis) models...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28690965/fabrication-of-hierarchically-porous-tio2-nanofibers-by-microemulsion-electrospinning-and-their-application-as-anode-material-for-lithium-ion-batteries
#10
Jin Zhang, Yibing Cai, Xuebin Hou, Xiaofei Song, Pengfei Lv, Huimin Zhou, Qufu Wei
Titanium dioxide (TiO2) nanofibers have been widely applied in various fields including photocatalysis, energy storage and solar cells due to the advantages of low cost, high abundance and nontoxicity. However, the low conductivity of ions and bulk electrons hinder its rapid development in lithium-ion batteries (LIB). In order to improve the electrochemical performances of TiO2 nanomaterials as anode for LIB, hierarchically porous TiO2 nanofibers with different tetrabutyl titanate (TBT)/paraffin oil ratios were prepared as anode for LIB via a versatile single-nozzle microemulsion electrospinning (ME-ES) method followed by calcining...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28677033/preparation-and-evaluation-of-self-microemulsions-for-improved-bioavailability-of-ginsenoside-rh1-and-rh2
#11
Feifei Yang, Jing Zhou, Xiao Hu, Stephanie Kyoungchun Yu, Chunyu Liu, Ruile Pan, Qi Chang, Xinmin Liu, Yonghong Liao
Due to intestinal cytochrome P450 (CYP450)-mediated metabolism and P-glycoprotein (P-gp) efflux, poor oral bioavailability hinders ginsenoside-Rh1 (Rh1) and ginsenoside-Rh2 (Rh2) from clinical application. In this study, Rh1 and Rh2 were incorporated into two self-microemulsions (SME-1 and SME-2) to improve oral bioavailability. SME-1 contained both CYP450 and P-gp inhibitory excipients while SME-2 only consisted of P-gp inhibitory excipients. Results for release, cellular uptake, transport, and lymph node distribution demonstrated no significant difference between either self-microemulsions in vivo, but were elevated significantly in comparison to the free drug...
July 5, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28672261/synthesis-of-hierarchical-flower-like-mg2al-cl-layered-double-hydroxide-in-a-surfactant-free-reverse-microemulsion
#12
Jie Xu, Huanhuan Deng, Jiaxin Song, Jun Zhao, Li Zhang, Wanguo Hou
Hierarchical flower-like Mg2Al-Cl LDH microspheres were synthesized using a reverse surfactant-free microemulsion (SFME) route at a low temperature (∼25°C), and characterized by XRD, TEM, SEM, FT-IR, TG, N2 adsorption/desorption, and elemental analyses. The SFME used consists of n-hexane, isopropanol, and water. The so-obtained flower-like microspheres are constructed with LDH nanosheets with ∼10nm thickness. After destroyed by calcination, their crystal structure and flower-like morphology can be reconstructed by rehydration...
June 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28670949/preparation-and-optimization-of-rivastigmine-loaded-tocopherol-succinate-based-solid-lipid-nanoparticles
#13
Fariba Malekpour-Galogahi, Ashrafalasadat Hatamian-Zarmi, Fariba Ganji, Bahman Ebrahimi-Hosseinzadeh, Fahimeh Nojoki, Razi Sahraeian, Zahra Beagom Mokhtari-Hosseini
Rivastigmine hydrogen tartrate (RHT) is a pseudo-irreversible inhibitor of cholinesterase, and is used for the treatment of Alzheimer's. However, RHT delivery to the brain is limited by the Blood-Brain Barrier (BBB). The purpose of this study was to improve the brain-targeting delivery of RHT by producing and optimizing rivastigmine hydrogen tartrate-loaded tocopherol succinate-based solid lipid nanoparticles (RHT-SLNs). RHT-SLNs were prepared using the microemulsion technique. The impact of significant variables such as surfactant concentration and drug/lipid ratio on the size of RHT-SLNs and their drug loading and encapsulation efficiency was analyzed using a five-level central composite design (CCD)...
July 2, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28661319/enhanced-photocatalytic-activity-of-ag-doped-zno-nanorods-for-degradation-of-an-azo-dye
#14
Mohammad Shokri, Ghodsieh Isapour, Mir Ghasem Hosseini, Qamar Zarbpoor
  In this study, Ag-ZnO nanophotocatalyst has been synthesized through microemulsion technique and the effect of silver modification on ZnO nanorods has been evaluated. The photocatalytic activity of nanocatalyst was examined by degradation of Acid Yellow 23 (AY23) as a model of mono azo dye under UV illumination. Ag-ZnO catalyst was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDXS) and diffuse reflectance spectroscopy (DRS) analysis...
November 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28654782/revisiting-blood-brain-barrier-a-chromatographic-approach
#15
Xavier Subirats, Laura Muñoz-Pascual, Michael H Abraham, Martí Rosés
Drugs designed to reach a pharmacological CNS target must be effectively transported across the blood-brain barrier (BBB), a thin monolayer of endothelial cells tightly attached together between the blood and the brain parenchyma. Because of the lipidic nature of the BBB, several physicochemical partition models have been studied as surrogates for the passive permeation of potential drug candidates across the BBB (octanol-water, alkane-water, PAMPA...). In the last years, biopartition chromatography is gaining importance as a noncellular system for the estimation of biological properties in early stages of drug development...
June 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28654267/ternary-silver-halide-nanocrystals
#16
Sasitha C Abeyweera, Kowsalya D Rasamani, Yugang Sun
Nanocrystalline silver halides (AgX) such as AgCl, AgBr, and AgI, a class of semiconductor materials with characteristics of both direct and indirect band gaps, represent the most crucial components in traditional photographic processing. The nanocrystal surfaces provide sensitivity specks that can turn into metallic silver, forming an invisible latent image, upon exposure to light. The photographic processing implies that the AgX nanoparticles possess unique properties. First, pristine AgX nanoparticles absorb light only at low efficiency to convert surface AgX into tiny clusters of silver atoms...
June 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28647602/improvement-of-lindane-removal-by-streptomyces-sp-m7-by-using-stable-microemulsions
#17
Juliana Maria Saez, Verena Casillas García, Claudia Susana Benimeli
Lindane is an organochlorine pesticide which persists in the environment and can cause serious health problems due to its chlorinated and hydrophobic nature. Microemulsions are isotropic and macroscopically homogeneous systems with high solubilization capacity of hydrophilic and hydrophobic compounds. The aim of this study was to evaluate the removal of high concentrations of lindane by the actinobacterium Streptomyces sp. M7 in aqueous and soil systems in the presence of stable microemulsions. Three stable microemulsions were successfully formed with Tween 80, 1-pentanol and three vegetable oils...
June 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28642916/the-antioxidant-effect-of-beackea-frutescence-microemulsions-dietary-supplements-on-skin-absorption-studies
#18
Mohd Zul Helmi Rozaini, Armiza Ahmad, Azizul Idris, Chen Fei Low, Mohd Effendy Abdul Wahid
Objective: To study the effect of two different microemulsions containing Beackea frutescence supplements composed of nerolidool, selenium and vitamin E on absorption effect related to skin health and skin aging. Materials and methods: A total of 39 volunteers with normal and healthy skin were divided into three groups (n = 13) and supplemented for a period of 12 weeks. Group 1 received a mixture of lutein (3 mg/day), lycopene (3 mg/day), α-tocopherol (10 mg/day), selenium (75 μg/day) and β-nerolidool (4...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642203/developments-of-polysorbate-tween-based-microemulsions-preclinical-drug-delivery-toxicity-and-antimicrobial-applications
#19
REVIEW
Gurpreet Kaur, S K Mehta
The present review deals with the progress of Polysorbates (Tween) based microemulsions in drug delivery. PEGylated Sorbitan Fatty Acid Esters (Tweens/Polysorbates) are one of the most used non-ionic surfactants. Particularly, Polysorbates based microemulsion has been widely used for enhancing solubilization of poorly soluble drugs. This article deals with underlying the preclinical factors which affect the solubilization efficacy of Tween formulations, implication of pharmaceutically accepted vectors in terms of absorption, bioavailability, biological fate and potential toxicity...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28638899/surface-cleaning-of-artworks-structure-and-dynamics-of-nanostructured-fluids-confined-in-polymeric-hydrogel-networks
#20
Rosangela Mastrangelo, Costanza Montis, Nicole Bonelli, Paolo Tempesti, Piero Baglioni
Nanosystems and confinement tools for the controlled release of a cleaning agent, e.g., hydrogels and microemulsions, have been used for several years for the treatment of delicate surfaces in art restoration interventions. However, notwithstanding the unprecedented achievements from an application point of view, a fundamental comprehension of their interaction mechanism is still lacking. In this study PVA hydrogels, obtained via freeze-thaw processes, are prepared as scaffolds for water-based nanostructured fluids for application in the cleaning of artworks: rheological, thermal, microscopic and scattering techniques showed that, depending on the number of freeze-thaw cycles, the hydrogels exhibit different physicochemical and viscoelastic properties, making them suitable for application in a broad range of cleaning issues...
June 22, 2017: Physical Chemistry Chemical Physics: PCCP
keyword
keyword
28415
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"