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Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, Upendra Nagaich
Nanotechnology manifests the progression in the arena of research and development, by increasing the efficacy of the product through delivery of innovative solutions. To overcome certain drawbacks associated with the traditional products, application of nanotechnology is escalating in the area of cosmeceuticals. Cosmeceuticals are regarded as the fastest growing segment of the personal care industry and the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have come into widespread use...
2018: Journal of Pharmaceutics
Nicole Bonelli, Costanza Montis, Antonio Mirabile, Debora Berti, Piero Baglioni
The presence of pressure-sensitive tapes (PSTs) on paper artworks, either fortuitous or specifically applied for conservation purposes, is one of the most frequent and difficult issues encountered during restoration. Aged PSTs can damage or disfigure artworks, compromising structural integrity, readability, and enjoyment. Current procedures are often inherently hazardous for artistic media and paper support. Challenged by the necessity to remove PSTs from a contemporary and an ancient drawing (20th century, by artists da Silva and Hayter, and a 16th century drawing of one figure from the Sistine Chapel by Michelangelo), we addressed this issue from a physicochemical perspective, leveraging colloid and interface science...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
Pedro André Arroyo, Sergio Alonso, Rodrigo Weber Dos Santos
Pattern formation has been widely observed in extended chemical and biological processes. Although the biochemical systems are highly heterogeneous, homogenized continuum approaches formed by partial differential equations have been employed frequently. Such approaches are usually justified by the difference of scales between the heterogeneities and the characteristic spatial size of the patterns. Under different conditions, for example, under weak coupling, discrete models are more adequate. However, discrete models may be less manageable, for instance, in terms of numerical implementation and mesh generation, than the associated continuum models...
March 2018: Physical Review. E
Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Yusuke Tanaka, Kunikazu Moribe
We present the absorption improvement mechanism of fenofibrate (FFB), a Biopharmaceutics Classification System (BCS) class II drug, from self-microemulsifying drug delivery systems (SMEDDS), centered on improving the diffusion of FFB through the unstirred water layer (UWL). Four SMEDDS formulations containing LabrafacTM lipophile WL 1349 (WL1349) or Labrafil® M 1944CS (M1944) oils and NIKKOL HCO-40 (HCO40) or NIKKOL HCO-60 (HCO60) surfactants were prepared. Every SMEDDS formulation formed microemulsion droplets of approximately 30 nm...
May 12, 2018: International Journal of Pharmaceutics
Kai Zhao, Dongqing Li
The ionic liquids (ILs) as the environmentally benign solvents show great potentials in microemulsion carrier systems and have been widely used in the biochemical and pharmaceutical fields. In the work, the ionic liquid-in-water microemulsions were fabricated by using two kinds of hydrophobic ionic liquid, 1-Butyl-3-methylimidazolium hexafluorophosphate [Bmim][PF6 ] and 1-Hexyl-3-methylimidazolium hexafluorophosphate [Hmim][PF6 ] with Tween 20. The ionic liquid droplets in water experience the dielectrophoretic (DEP) forces induced by applying electrical field via a nano-orifice and a micron orifice on the opposite channel walls of a microchannel...
May 9, 2018: Journal of Chromatography. A
Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Krutika K Sawant, Bharat Bhushan Subudhi
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation. In this work, ibuprofen loaded polycarbophil based mucoadhesive microemulsion (MMEI) was developed by using response surface methodology (RSM)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Nurettin Sahiner
Here, a facile method for the preparation of polymeric particles from a sugar molecule, maltitol (ML) in single step was reported via microemulsion polymerization/crosslinking technique with a high yield, 89 ± 6%. Furthermore, poly(Maltitol) (p(ML)) particles were chemically modified to induce different physicochemical characteristic using different anionic and cationic modifying agents such as taurine (TA) and diethylenetriamine (DETA) to prepare m-p(ML)/TA and m-p(ML)/DETA. The blood compatibility of the p(ML) particles and their modified forms were tested with fresh blood, and found that p(ML) and m-(ML)/DETA particles are blood compatible with about 5% hemolysis, and above 80% blood clotting indices...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Ane Bordagaray, Rosa Garcia-Arrona, Maider Vidal, Miren Ostra
Color additives are used widely by the food industry to confer a desirable appearance. Some of the most used colorants (Tartrazine (E102), Sunset Yellow (E110), Red Allure (E129) and Blue Brilliant (E133)) were determined in this study using microemulsion electrokinetic capillary chromatography (MEEKC). Regression coefficients were greater than 0.9981; intra- and inter-day precisions, in terms of percentage RSD, were less than 7.01% and 8.55%, respectively; recoveries were between 90 and 100% in most cases...
October 1, 2018: Food Chemistry
Tomasz M Stawski, Teresa Roncal-Herrero, Alejandro Fernandez-Martinez, Adriana Matamoros-Veloza, Roland Kröger, Liane G Benning
Can we control the crystallization of solid CaCO3 from supersaturated aqueous solutions and thus mimic a natural process predicted to occur in living organisms that produce biominerals? Here we show how we achieved this by confining the reaction between Ca2+ and CO32- ions to the environment of nanosized water cores of water-in-oil microemulsions, in which the reaction between the ions is controlled by the intermicellar exchange processes. Using a combination of in situ small-angle X-ray scattering, high-energy X-ray diffraction, and low-dose liquid-cell scanning transmission electron microscopy, we elucidate how the presence of micellar interfaces leads to the formation of a solute CaCO3 phase/species that can be stabilized for extended periods of time inside micellar water nano-droplets...
May 10, 2018: Physical Chemistry Chemical Physics: PCCP
Yuanchao Pei, Jie Ru, Kaisheng Yao, Lihui Hao, Zhiyong Li, Huiyong Wang, Xingqi Zhu, Jianji Wang
It is a challenge to develop microemulsions which can serve as nanoreactors for the synthesis of nanoparticles and chemical reactions at high temperature. In this work, a class of novel high temperature microemulsions consisting solely of ionic liquids have been designed and prepared for the first time. It is found that nanoscale droplets formed in the ionic liquid microemulsions can be maintained up to 200 °C, and the size distribution of the droplets can be easily tuned by selection of the ionic liquids and varying compositions of the systems...
May 10, 2018: Chemical Communications: Chem Comm
Mojtaba Delfanian, Seyed M A Razavi, Mohammad Hossein Haddad Khodaparast, Reza Esmaeilzadeh Kenari, Shiva Golmohammadzadeh
In this study, the effect of natural macromolecules as carrier agents on the biological activity of nano-encapsulated Bene hull polyphenols (Pistacia atlantica subsp. Mutica) through W/O/W emulsions was evaluated. The W/O microemulsions as primary emulsions and a complex of soy protein isolate and basil seed gum (SPI-BSG), whey protein isolate and basil seed gum (WPI-BSG) and also Hi-Cap 100 in the outer aqueous phase were used to produce W/O/W nano-emulsions. Z-average size of emulsions stabilized by Hi-Cap, WPI-BSG, and SPI-BSG was 318, 736...
June 2018: Food Research International
Mohamed H Aboumanei, Aly A Abdelbary, Ismail T Ibrahim, Mina I Tadros, Mohamed T El-Kolaly
A10, (3-phenylacetylamino-2,6-piperidinedione), is a natural peptide with broad antineoplastic activity. Recently, in vitro antitumor effect of a new A10 analog [3-(4-methoxybenzoylamino)-2,6-piperidinedione] (MPD) has been verified. However, poor aqueous solubility represents an obstacle towards intravenous formulation of MPD and impedes successful in vivo antitumor activity. To surmount such limitation, MPD microemulsion (MPDME) was developed. A 31 22 full factorial design using Design-Expert® software was adopted to study the influence of different parameters and select the optimum formulation (MPDME1)...
May 4, 2018: International Journal of Pharmaceutics
Duoduo Jiang, Lifang Duan, Runan Li, Xinglu Pan, Yan Tao, Xiaohu Wu, Jun Xu, Xingang Liu, Fengshou Dong, Yongquan Zheng
Wax gourd is a popular vegetable and the new organic copper pesticide product of copper nonylphenolsulfonate and hexaconazole was firstly recommended to control the serious disease powdery mildew frequently occurred in wax gourd. However, it is still a concern for data deficiency of residue amounts of these two pesticides in edible portion of wax gourd and the persistence in environment. In this study, the dissipation and residue of copper nonylphenolsulfonate and hexaconazole in wax gourd and soil were investigated...
May 3, 2018: Ecotoxicology and Environmental Safety
Yao Cheng, Pengxuan Zhao, Shuangping Wu, Tan Yang, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Chao Zheng, Kelin Li, Xiang Ma, Guangya Xiang
Hepatocellular carcinoma (HCC) continues to be a leading cause of cancer related death in the world. Conventional chemotherapeutic agents such as cisplatin (CDDP) have an unsatisfactory efficacy on HCC due to the poor response, severe toxicity and drug resistance. Curcumin (CUR) could improve the chemosensitivity of HCC to chemotherapy drugs by regulating a variety of signaling pathways. Herein, we describe a combination strategy using co-loaded liposomes to effectively deliver and release CDDP and curcumin (CUR) to HCC for overcoming the unsatisfactory clinical outcome of CDDP monotherapy...
May 3, 2018: International Journal of Pharmaceutics
Chen Chen, Rui-Han Li, Bai-Sheng Zhu, Kun-Hua Wang, Ji-Song Yao, Yi-Chen Yin, Ming-Ming Yao, Hong-Bin Yao, Shu-Hong Yu
Aggregation-Induced Emission (AIE) is an attractive phenomenon that the materials display strong luminescence at the aggregated solid states rather than conventional dissolved molecular states. However, highly luminescent inks based on AIE is hard to be obtained because of the difficulty to finely control the crystallinity of AIE materials at nanoscale. Here, we report the fabrication of highly luminescent inks via oil-in-water microemulsion induced aggregation of Cu-I hybrid clusters based on our synthesized highly soluble copper iodide-tris(3-methylphenyl)phosphine (Cu4I4(P-(m-Tol)3)4) hybrid for the first time...
May 3, 2018: Angewandte Chemie
R Riccò, S Nizzero, E Penna, A Meneghello, E Cretaio, F Enrichi
In modern biosensing and imaging, fluorescence-based methods constitute the most diffused approach to achieve optimal detection of analytes, both in solution and on the single-particle level. Despite the huge progresses made in recent decades in the development of plasmonic biosensors and label-free sensing techniques, fluorescent molecules remain the most commonly used contrast agents to date for commercial imaging and detection methods. However, they exhibit low stability, can be difficult to functionalise, and often result in a low signal-to-noise ratio...
2018: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
Ruttiros Khonkarn, Ornanong S Kittipongpatana, Vilai Boasouna, Siriporn Okonogi
Ketoconazole is photolabile antifungal drug. Photochemical reactions may decrease its therapeutic effect or induce toxic compounds. The aim of this study was to prepare ketoconazole loaded microemulsion containing H. suaveolens oil with antifungal and antioxidant powers in order to obtain effective antifungal formulation. The release study, antifungal activity and photostability test, were then evaluated. The results showed that optimized Hyptis suaveolens microemulsion for ketoconazole loading was selected through construction of pseudo-ternary phase diagrams...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Bin Sun, Jinling Chai, Ziqiang Chai, Xiaoyu Zhang, Xiaocui Cui, Jianjun Lu
A new type of surfactant-free microemulsion (SFME) containing water/ethanol/dichloromethane was constructed, and three microregions water-in-dichloromethane (W/O), bicontinuous (B.C.) and dichloromethane-in-water (O/W) regions were identified. The polarity environment of the SFME was investigated. Solid silica nanoparticle (SSN) was selected as a model nanomaterial to investigate the feasibility of the water/ethanol/dichloromethane SFME for the preparation of nanomaterials. In the O/W SFME region of the microemulsions, uniform spherical solid silica nanoparticles (SSNs) were synthesized...
April 19, 2018: Journal of Colloid and Interface Science
Manuchar Gvaramia, Gaetano Mangiapia, Peter Falus, Michael Ohl, Olaf Holderer, Henrich Frielinghaus
The capillary condensation in bicontinuous microemulsions takes place when two parallel surfaces are narrowed that result in a completely lamellar microemulsion. We expected that this phase transition is also observable when the amount of hydrophilic surfaces from clay particles is raised, because hydrophilic surfaces induce lamellar ordering locally. Using small angle neutron scattering, the structure of microemulsions was observed as a function of clay content. The critical concentration is indicated by discontinuous structural changes and depends on the platelet diameter and is explained by the free energy of the platelets competing with the fluctuating medium...
April 22, 2018: Journal of Colloid and Interface Science
Marta Benigni, Silvia Pescina, Maria Aurora Grimaudo, Cristina Padula, Patrizia Santi, Sara Nicoli
Psoriasis is a widespread chronic disease affecting 2-4% of the population in Western countries. Its mild-to-moderate form, representing approximately 80% of the total cases, is treated by topical application, with corticosteroid being the standard treatment. However, in case of psoriasis, no single treatment works for every patient and optimizing topical therapy is a key aspect. A possible alternative is represented by cyclosporine, an immunosuppressant cyclic peptide administered orally in the treatment of the severe form...
April 23, 2018: International Journal of Pharmaceutics
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