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https://www.readbyqxmd.com/read/28934172/topical-nano-and-microemulsions-for-skin-delivery
#1
REVIEW
Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation...
September 21, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28929143/enhanced-stability-and-water-solubilizing-capacity-of-water-in-oil-microemulsions-based-on-protic-ionic-liquids
#2
Akhil Pratap Singh, Kaushik Kundu, Vikram Singh, Ramesh L Gardas, Sanjib Senapati
In an attempt to increase the stability and water uptake capacity of water-in-oil (W/O) microemulsions, here we study the physicochemical behavior of a series of protic ionic liquid based water/oil microemulsions, wherein solute amounts of biocompatible tetramethylguanidinium cation-based ionic liquids (ILs) are added to the aqueous phase of water-in-oil (W/O) microemulsions. FTIR and time-resolved fluorescence measurements showed an increased water uptake in these reverse micellar droplets, compared to conventional W/O microemulsions of similar compositions...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28922633/protein-extraction-into-the-bicontinuous-microemulsion-phase-of-a-water-sds-pentanol-dodecane-winsor-iii-system-effect-on-nanostructure-and-protein-conformation
#3
Douglas G Hayes, Ran Ye, Rachel N Dunlap, Matthew J Cuneo, Sai Venkatesh Pingali, Hugh M O'Neill, Volker S Urban
Bicontinuous microemulsions (BμEs), consisting of water and oil nanodomains separated by surfactant monolayers of near-zero curvature, are potentially valuable systems for purification and delivery of biomolecules, for hosting multiphasic biochemical reactions, and as templating media for preparing nanomaterials. We formed Winsor-III systems by mixing aqueous protein and sodium dodecyl sulfate (SDS) solutions with dodecane and 1-pentanol (cosurfactant) to efficiently extract proteins into the middle (BμE) phase...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28917875/collagen-and-hyaluronic-acid-hydrogel-in-water-in-oil-microemulsion-delivery-systems
#4
Sylwia Kupper, Ilona Kłosowska-Chomiczewska, Patrycja Szumała
The increase in skin related health issues has promoted interest in research on the efficacy of microemulsion in dermal and transdermal delivery of active ingredients. Here, we assessed the water-in-oil microemulsion capacity to incorporate two natural polymers, i.e. collagen and hyaluronic acid with low and high molecular weight. Systems were extensively characterized in terms of conductivity, phase inversion studies, droplet diameter, polydispersity index and rheological properties. The results of this research indicate that the structure and extent of water phase in microemulsions is governed by ratio and amount of surfactant mixture (sorbitan ester derivatives)...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28911665/nanostructures-current-uses-and-future-applications-in-food-science
#5
REVIEW
Kavitha Pathakoti, Manjunath Manubolu, Huey-Min Hwang
Recent developments in nanoscience and nanotechnology intend novel and innovative applications in the food sector, which is rather recent compared with their use in biomedical and pharmaceutical applications. Nanostructured materials are having applications in various sectors of the food science comprising nanosensors, new packaging materials, and encapsulated food components. Nanostructured systems in food include polymeric nanoparticles, liposomes, nanoemulsions, and microemulsions. These materials enhance solubility, improve bioavailability, facilitate controlled release, and protect bioactive components during manufacture and storage...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28898468/nanodroplet-containing-polymers-for-efficient-low-power-light-upconversion
#6
Roberto Vadrucci, Angelo Monguzzi, Felipe Saenz, Bodo D Wilts, Yoan C Simon, Christoph Weder
Sensitized triplet-triplet-annihilation-based photon upconversion (TTA-UC) permits the conversion of light into radiation of higher energy and involves a sequence of photophysical processes between two dyes. In contrast to other upconversion schemes, TTA-UC allows the frequency shifting of low-intensity light, which makes it particularly suitable for solar-energy harvesting technologies. High upconversion yields can be observed for low viscosity solutions of dyes; but, in solid materials, which are better suited for integration in devices, the process is usually less efficient...
September 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28895963/small-angle-neutron-scattering-study-of-a-dense-microemulsion-system-formed-with-an-ionic-liquid
#7
T Kang, S Qian, G S Smith, C Do, W T Heller
Mixtures of water, octane and 1-octanol with 1-tetradecyl-3-methylimidazolium chloride (C14MIM·Cl), often referred to as a surface active ionic liquid (SAIL), form water-in-oil microemulsions that have potential application as extraction media for various metal ions. Here, we present a structural study by small-angle neutron scattering (SANS) of dense microemulsions formed by surfactant-rich mixtures of these four compounds to understand how the SAIL can be used to tune the structures and properties of the microemulsions...
September 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28880210/comparative-pharmacokinetic-study-for-linezolid-and-two-novel-antibacterial-oxazolidinone-derivatives-in-rabbits-can-differences-in-the-pharmacokinetic-properties-explain-the-discrepancies-between-their-in-vivo-and-in-vitro-antibacterial-activities
#8
Mohsen A Hedaya, Vidhya Thomas, Mohamed E Abdel-Hamid, Elijah O Kehinde, Oludotun A Phillips
This is a comparative pharmacokinetics study of linezolid (Lzd), and two novel oxazolidinone antibacterial agents-PH027 and PH051-in rabbits to determine if the discrepancy between the in vitro and in vivo activities of the novel compounds is due to pharmacokinetic factors. The pharmacokinetics after IV and oral administration, plasma protein binding and tissue distribution for the three compounds were compared. The elimination half-lives were 52.4 ± 6.3, 68.7 ± 12.1 and 175 ± 46.1 min for Lzd, PH027 and PH051, respectively...
September 7, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28866359/micro-matrix-solid-phase-dispersion-coupled-with-meekc-for-quantitative-analysis-of-lignans-in-schisandrae-chinensis-fructus-using-molecular-sieve-ts-1-as-a-sorbent
#9
Chu Chu, Mengmeng Wei, Shan Wang, Liqiong Zheng, Zheng He, Jun Cao, Jizhong Yan
A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type of dispersant, mass ratio of the sample to the dispersant, grinding time, elution solvent and volume were optimized...
August 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28860764/liposomal-curcumin-and-its-application-in-cancer
#10
REVIEW
Ting Feng, Yumeng Wei, Robert J Lee, Ling Zhao
Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28858477/microemulsion-based-soft-bacteria-driven-microswimmers-for-active-cargo-delivery
#11
Ajay Vikram Singh, Zeinab Hosseinidoust, Byung-Wook Park, Oncay Yasa, Metin Sitti
Biohybrid cell-driven microsystems offer unparalleled possibilities for realization of soft microrobots at the micron scale. Here, we introduce a bacteria-driven microswimmer that combines the active locomotion and sensing capabilities of bacteria with the desirable encapsulation and viscoelastic properties of a soft double-micelle microemulsion for active transport and delivery of cargo (e.g., imaging agents, genes, and drugs) to living cells. Quasi-monodisperse double emulsions were synthesized with an aqueous core that encapsulated the fluorescence imaging agents, as a proof-of-concept cargo in this study, and an outer oil shell that was functionalized with streptavidin for specific and stable attachment of biotin-conjugated Escherichia coli...
September 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28846386/pressure-responsive-surfactant-free-co2-based-nanostructured-fluids
#12
Natascia Grimaldi, Paula Elena Rojas, Simon Stehle, Alba Cordoba, Ralf Schweins, Santi Sala, Stefan Luelsdorf, David Piña, Jaume Veciana, Jordi Faraudo, Alessandro Triolo, Andreas Siegfried Braeuer, Nora Ventosa
Microemulsions are extensively used in advanced material and chemical processing. However, considerable amounts of surfactant are needed for their formulation, which is a drawback due to both economic and ecological reasons. Here, we describe the nanostructuration of recently discovered surfactant-free, carbon dioxide (CO2)-based microemulsion-like systems in water/organic-solvent/CO2 pressurized ternary mixture. "Water-rich" nanodomains embedded into a "water-depleted" matrix have been observed and characterized by the combination of Raman spectroscopy, molecular dynamics simulations and small angle neutron scattering...
August 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28842315/bisphosphonate-functionalized-coordination-polymer-nanoparticles-for-the-treatment-of-bone-metastatic-breast-cancer
#13
Yuanfeng He, Yanjuan Huang, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao
Bone is the most common organ affected by metastatic breast cancer. Targeting cancers within the bone remains a great challenge due to the inefficient delivery of therapeutic to bone. In this study, a polyethylene glycol (PEG) coated nanoparticles (NPs) made of a Zn(2+) coordination polymer was linked with a bone seeking moiety, alendronate (ALN), to deliver cisplatin prodrug (DSP) to the bone. The particle sizes of this novel system, DSP-Zn@PEG-ALN NPs, were regulated by adjusting the volume ratio of water phase to oil phase in microemulsion...
August 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28841044/a-multicomponent-microemulsion-using-rational-combination-strategy-improves-lung-cancer-treatment-through-synergistic-effects-and-deep-tumor-penetration
#14
Ding Qu, Mengfei Guo, Yue Qin, Lixiang Wang, Bing Zong, Yunyan Chen, Yan Chen
Previously, we have developed a multicomponent-based microemulsion composed of etoposide, coix seed oil, and ginsenoside Rh2 (ECG-MEs). In this study, our goal was to validate the feasibility of ECG-MEs in lung cancer treatment and explore the mechanism underling the enhanced antitumor efficacy. The optimal weight ratio of ginsenoside Rh2 (G-Rh2) in ECG-MEs was determined as 3% (wt%), that was capable of forming the microemulsion readily with small particle size and high drug encapsulation efficiency. In cellular studies, the intracellular fluorescence of human non-small cell lung cancer (A549) cells treated with fluorescein isothiocyanate-labeled ECG-MEs (FITC/ECG-MEs) was significantly higher than that of various controls, leading to the obviously synergistic anticancer activities in cytotoxicity and in vitro cell apoptosis induction...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28836273/clotrimazole-microemulsion-and-microemulsion-based-gel-evaluation-of-buccal-drug-delivery-and-irritancy-using-chick-chorioallantoic-membrane-as-the-model
#15
Jarika Kaewbanjong, Paul Wan Sia Heng, Prapaporn Boonme
OBJECTIVES: To investigate the efficacy of clotrimazole microemulsion (CTZ-ME) and its gel form, clotrimazole microemulsion-based gel (CTZ-MBG), for the treatment of oral candidiasis. METHODS: CTZ-ME and CTZ-MBG were characterized for droplet size and texture, respectively. The ex-vivo permeation study and irritancy assessment of CTZ-ME and CTZ-MBG were performed using chick chorioallantoic membrane (CAM) as the model. Antifungal activity against Candida albicans ATCC 10 231 of CTZ-ME and CTZ-MBG was determined by agar diffusion method compared to the blank counterparts...
August 24, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28831842/transdermal-agomelatine-microemulsion-gel-pyramidal-screening-statistical-optimization-and-in-vivo-bioavailability
#16
Mayada Said, Ibrahim Elsayed, Ahmed A Aboelwafa, Ahmed H Elshafeey
Agomelatine is a new antidepressant having very low oral drug bioavailability less than 5% due to being liable to extensive hepatic 1st pass effect. This study aimed to deliver agomelatine by transdermal route through formulation and optimization of microemulsion gel. Pyramidal screening was performed to select the most suitable ingredients combinations and then, the design expert software was utilized to optimize the microemulsion formulations. The independent variables of the employed mixture design were the percentages of capryol 90 as an oily phase (X1), Cremophor RH40 and Transcutol HP in a ratio of (1:2) as surfactant/cosurfactant mixture 'Smix' (X2) and water (X3)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28831254/development-of-a-novel-microemulsion-for-oral-absorption-enhancement-of-all-trans-retinoic-acid
#17
Thirapit Subongkot, Tanasait Ngawhirunpat
This study was aimed to develop a novel microemulsion that contained oleth-5 as a surfactant to enhance the oral absorption of all-trans retinoic acid (ATRA). The prepared microemulsion was evaluated for its particle size, shape, zeta potential, in vitro release, in vitro intestinal absorption, intestinal membrane cytotoxicity and stability. The obtained microemulsion was spherical in shape with a particle size of <200 nm and a negative surface charge. The in vitro release of the ATRA-loaded microemulsion was best fit with the zero-order model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28829337/cd-free-cu-zn-in-s-zns-quantum-dots-sio2-multiple-cores-nanostructure-preparation-and-application-for-white-leds
#18
Tong Tong Jiang, Mohan Shen, Peng Dai, Mingzai Wu, Xinxin Yu, Guang Li, Xiaoliang Xu, Haibo Zeng
The work reports the fabrication of Cu doped Zn-In-S (CZIS) alloy quantum dots (QDs) using dodecanethiol (DDT) and oleic acid (OA) as stabilizing ligands. With the increase of doped Cu element, the photoluminescence (PL) peak is monotonically red shifted. After coating ZnS shell, the PL quantum yield (QY) of CZIS QDs can reach 78%. Using reverse micelle microemulsion method, CZIS/ZnS QDs@SiO2 multi-core nanospheres were synthesized to improve the colloidal stability and avoid the aggregation of QDs. The obtained multi-core nanospheres were dispersed in curing adhesive, and applied as color conversion layer in down converted light-emitting diodes (DC-LEDs)...
August 22, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28829089/polymer-conformation-in-nanoscopic-soft-confinement
#19
Björn Kuttich, Isabelle Grillo, Sebastian Schöttner, Markus Gallei, Bernd Stühn
We study the conformation of a polymer (polyethylene glycol) in a nanoscopic soft confinement with attractive walls. The polymer is added to a water-in-oil microemulsion based on the deuterated anionic surfactant AOT, d-octane and D2O. Three different droplet sizes and up to three polymers per droplet are investigated with small angle scattering combining X-rays and neutrons. This allows determining the confinement size and polymer conformation on identical samples. Whereas polymer conformation in bulk is found to be well described with the model of a Gaussian coil its radius of gyration is drastically increased in the droplet...
August 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28828910/phase-transition-of-a-microemulsion-upon-addition-of-cyclodextrin-applications-in-drug-delivery
#20
Sachin S Thakur, Jared Solloway, Anneloes Stikkelman, Ali Seyfoddin, Ilva D Rupenthal
This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization followed by evaluation of their in vitro drug release and ex vivo tissue retention behavior. Combining microemulsions with cyclodextrins resulted in either phase separation or transition into a liquid crystalline state depending the concentration and type of cyclodextrin utilized...
August 22, 2017: Pharmaceutical Development and Technology
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