keyword
MENU ▼
Read by QxMD icon Read
search

microemulsion

keyword
https://www.readbyqxmd.com/read/28642916/the-antioxidant-effect-of-beackea-frutescence-microemulsions-dietary-supplements-on-skin-absorption-studies
#1
Mohd Zul Helmi Rozaini, Armiza Ahmad, Azizul Idris, Chen Fei Low, Mohd Effendy Abdul Wahid
Objective: To study the effect of two different microemulsions containing Beackea frutescence supplements composed of nerolidool, selenium and vitamin E on absorption effect related to skin health and skin aging. Materials and methods: A total of 39 volunteers with normal and healthy skin were divided into three groups (n = 13) and supplemented for a period of 12 weeks. Group 1 received a mixture of lutein (3 mg/day), lycopene (3 mg/day), α-tocopherol (10 mg/day), selenium (75 μg/day) and β-nerolidool (4...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642203/developments-of-polysorbate-tween-based-microemulsions-preclinical-drug-delivery-toxicity-and-antimicrobial-applications
#2
REVIEW
Gurpreet Kaur, S K Mehta
The present review deals with the progress of Polysorbates (Tween) based microemulsions in drug delivery. PEGylated Sorbitan Fatty Acid Esters (Tweens/Polysorbates) are one of the most used non-ionic surfactants. Particularly Polysorbates based microemulsion has been widely used for enhancing solubilization of poorly soluble drugs. This article deals with underlying the preclinical factors which affect the solubilization efficacy of Tween formulations, implication of pharmaceutically accepted vectors in terms of absorption, bioavailability, biological fate and potential toxicity...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28638899/surface-cleaning-of-artworks-structure-and-dynamics-of-nanostructured-fluids-confined-in-polymeric-hydrogel-networks
#3
Rosangela Mastrangelo, Costanza Montis, Nicole Bonelli, Paolo Tempesti, Piero Baglioni
Nanosystems and confinement tools for the controlled release of a cleaning agent, e.g., hydrogels and microemulsions, have been used for several years for the treatment of delicate surfaces in art restoration interventions. However, notwithstanding the unprecedented achievements from an application point of view, a fundamental comprehension of their interaction mechanism is still lacking. In this study PVA hydrogels, obtained via freeze-thaw processes, are prepared as scaffolds for water-based nanostructured fluids for application in the cleaning of artworks: rheological, thermal, microscopic and scattering techniques showed that, depending on the number of freeze-thaw cycles, the hydrogels exhibit different physicochemical and viscoelastic properties, making them suitable for application in a broad range of cleaning issues...
June 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28633547/lipid-based-nanosystem-of-edaravone-development-optimization-characterization-and-in-vitro-in-vivo-evaluation
#4
Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral use is restricted due to poor oral bioavailability (BA). The aim of present research was to enable its oral use by developing a lipid-based nanosystem (LNS). The components of LNS including oil, surfactants, and co-surfactants were selected based on their potential to maximize the solubilization in gastrointestinal (GI) fluids, reduce its glucuronidation and improve transmembrane permeability...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28632272/interfacial-synthesis-of-a-three-dimensional-hierarchical-mos2-ns-ag-np-nanocomposite-as-a-sers-nanosensor-for-ultrasensitive-thiram-detection
#5
Xiu Liang, Yi-Shuo Wang, Ting-Ting You, Xiao-Juan Zhang, Nan Yang, Guang-Sheng Wang, Peng-Gang Yin
Interfacial self-assembly of ordered nanostructures at oil-water interfaces towards the fabrication of nanofilms has attracted the interest of plenty of scientists, since its discovery in 2004. Herein, further developments have been achieved, and we report a new strategy for the synthesis of a three-dimensional (3D) hierarchical nanostructure, through an interfacial synthesis driven microemulsion process. Thus, the synthesis route has been simplified, with the rigorous experimental conditions of traditional compositing technology...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28631792/nanoscopic-dynamics-of-bicontinous-microemulsions-effect-of-membrane-associated-protein
#6
V K Sharma, Douglas G Hayes, Volker S Urban, Hugh M O'Neill, M Tyagi, E Mamontov
Bicontinous microemulsions (BμE) generally consist of nanodomains formed by surfactant in a mixture of water and oil at nearly equal proportions and are potential candidates for the solubilization and purification of membrane proteins. Here we present the first time report of nanoscopic dynamics of surfactant monolayers within BμEs formed by the anionic surfactant sodium dodecyl sulfate (SDS) measured on the nanosecond to picosecond time scale using quasielastic neutron scattering (QENS). BμEs investigated herein consisted of middle phases isolated from Winsor-III microemulsion systems that were formed by mixing aqueous and oil solutions under optimal conditions...
June 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28629978/dual-roles-of-tpgs-based-microemulsion-for-tacrolimus-enhancing-the-percutaneous-delivery-and-anti-psoriatic-efficacy
#7
Tao Wan, Jingtong Pan, Yueming Long, Kaiyue Yu, Yixuan Wang, Wenhui Pan, Wenyi Ruan, Mengyao Qin, Chuanbin Wu, Yuehong Xu
In this study, we demonstrate for the first time the dual roles of Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) based microemulsion (ME) for tacrolimus (TAC) to enhance TAC percutaneous delivery and anti-psoriatic efficacy. The ME formulation was developed and optimized based on pseudo-ternary phase diagrams combined with in vitro permeation. The result of Fourier transform infrared spectroscopy (FTIR) demonstrated that TAC was completely solubilized in the TPGS-ME. In vitro permeation studies showed that TPGS-ME enhanced TAC permeation through and into the skin, and the enhanced deposition of TAC in the normal or psoriatic skin was further confirmed in vivo...
June 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28621928/aluminum-oxy-hydroxide-nanosticks-synthesized-in-bicontinuous-reverse-microemulsion-have-potent-vaccine-adjuvant-activity
#8
Xu Li, Stephanie Hufnagel, Haiyue Xu, Solange A Valdes, Sachin G Thakkar, Zhengrong Cui, Hugo Celio
Insoluble aluminum salts such as aluminum (oxy)hydroxide are commonly used vaccine adjuvants. Recently, there is evidence suggesting that the adjuvant activity of aluminum salt-based materials is tightly related to their physico-chemical properties, including nanometer-scale size, shape with long aspect ratio, and low degree of crystallinity. Herein, for the first time, the bicontinuous reverse microemulsion (RM) technique was utilized to synthesize stick-like monodisperse aluminum (oxy)hydroxide nanoparticles with a long aspect ratio of ~10, length of ~80 nm and low degree of crystallinity (denoted as Al-nanosticks)...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28619449/development-of-semisolid-self-microemulsifying-drug-delivery-systems-smeddss-filled-in-hard-capsules-for-oral-delivery-of-aciclovir
#9
Ljiljana Djekic, Jovana Jankovic, Bojan Čalija, Marija Primorac
The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six self-dispersing systems (SD1-SD6) were prepared by loading aciclovir into the semisolid formulations consisting of medium chain length triglycerides (lipid), macrogolglycerol hydroxystearate (surfactant), polyglyceryl-3-dioleate (cosurfactant), glycerol (hydrophilic cosolvent), and macrogol 8000 (viscosity modifier). Their characterization was performed in order to identify the semisolid system with rheological behaviour suitable for filling in hard HPMC capsules and fast dispersibility in acidic and alkaline aqueous media with formation of oil-in-water microemulsions...
June 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28606033/tc-99m-radiolabeled-alendronate-sodium-microemulsion-characterization-and-permeability-studies-across-caco-2-cells
#10
Yetkin Elitez, Meliha Ekinci, Derya Ilem-Ozdemir, Evren Gundogdu, Makbule Asikoglu
BACKGROUND: Alendronate sodium (ALD) is used orally but it is poorly absorbed from the gastrointestinal (GI) tract. For this reason, microemulsion system was chosen to evaluate ALD from the GI tract after oral delivery. OBJECTIVE: This study was aimed to prepare water-in-oil (w/o) microemulsion formulation of ALD and evaluate the permeability of ALD microemulsion from Caco-2 cell lines with radioactive and non-radioactive studies. METHOD: The ALD microemulsion was developed by using pseudo-ternary phase diagram and composed of Soybean oil, Colliphor EL, Tween 80, Transcutol and distilled water...
June 12, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28595151/ionic-liquids-for-low-tension-oil-recovery-processes-phase-behavior-tests
#11
Iria Rodriguez-Escontrela, Maura C Puerto, Clarence A Miller, Ana Soto
Chemical flooding with surfactants for reducing oil-brine interfacial tensions (IFTs) to mobilize residual oil trapped by capillary forces has a great potential for Enhanced Oil Recovery (EOR). Surface-active ionic liquids (SAILs) constitute a class of surfactants that has recently been proposed for this application. For the first time, SAILs or their blends with an anionic surfactant are studied by determining equilibrium phase behavior for systems of about unit water-oil ratio at various temperatures. The test fluids were model alkane and aromatic oils, NaCl brine, and synthetic hard seawater (SW)...
May 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28594418/microemulsion-made-gadolinium-carbonate-hollow-nanospheres-showing-magnetothermal-heating-and-drug-release
#12
J Jung-König, M Sanhaji, R Popescu, C Seidl, E Zittel, U Schepers, D Gerthsen, I Hilger, C Feldmann
Gadolinium carbonate (Gd2(CO3)3) hollow nanospheres and their suitability for drug transport and magnetothermally-induced drug release are presented. The hollow nanospheres are prepared via a microemulsion-based synthesis using tris(tetramethylcyclopentadienyl)gadolinium(iii) and CO2 as the starting materials. Size, structure and composition of the as-prepared Gd2(CO3)3 hollow nanospheres are comprehensively validated by several independent analytical methods (HRTEM, HAADF-STEM, DLS, EDXS, XRD, FT-IR, DTA-TG)...
June 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/28590913/testing-of-resveratrol-microemulsion-photostability-and-protective-effect-against-uv-induced-oxidative-stress
#13
Vaida Juškaitė, Kristina Ramanauskienė, Vitalis Briedis
Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28590136/controlling-photocatalytic-activity-and-size-selectivity-of-tio2-encapsulated-in-hollow-silica-spheres-by-tuning-silica-shell-structures-using-sacrificial-biomolecules
#14
Kensei Fujiwara, Yasutaka Kuwahara, Yuki Sumida, Hiromi Yamashita
Yolk-shell nanostructured photocatalyst which consists of inner core photocatalytic particles and outer silica shell exhibits high photocatalytic efficiency and molecular size selectivity due to the molecular sieving property of the outer shell. Creation of extended porosity in the shell endows it with improved adsorption properties and size selectivity toward targeted reactants. In this study, yolk-shell nanostructured photocatalyst consisting of TiO2 NPs core and porous silica shell with controllable pore size was fabricated through a facile single-step dual-templating approach utilizing oil-in-water (O/W) microemulsions and amphiphilic protein molecules...
June 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28589445/chemoprevention-of-breast-cancer-by-transdermal-delivery-of-%C3%AE-santalol-through-breast-skin-and-mammary-papilla-nipple
#15
Kaushalkumar Dave, Fahd M Alsharif, Saiful Islam, Chandradhar Dwivedi, Omathanu Perumal
PURPOSE: Almost all breast cancers originate from epithelial cells lining the milk ducts in the breast. To this end, the study investigated the feasibility of localized transdermal delivery of α-santalol, a natural chemopreventive agent to the breast. METHODS: Different α-santalol formulations (cream, solution and microemulsion) were developed and the in vitro permeability was studied using excised animal (porcine and rat) and human breast skin/mammary papilla (nipple)...
June 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28577837/mir-375-delivered-by-lipid-coated-doxorubicin-calcium-carbonate-nanoparticles-overcomes-chemoresistance-in-hepatocellular-carcinoma
#16
Pengxuan Zhao, Shuangping Wu, Yao Cheng, Jia You, Yan Chen, Minsi Li, Chuanchuan He, Xiaojuan Zhang, Tan Yang, Yao Lu, Robert J Lee, Xingxing He, Guangya Xiang
Hepatocellular carcinoma (HCC) is a prevalent and lethal disease that is characterized by drug resistance. Doxorubicin (DOX) is a widely used chemotherapeutic drug and miR-375 has been shown to be a tumor suppressor in HCC. Here, we reported that miR-375 and DOX co-loaded into lipid-coated calcium carbonate nanoparticles (LCC-DOX/miR-375 NPs), enhanced the anti-tumor effects through combination therapy, and were highly effective in reversing drug resistance in HCC. LCC-DOX/miR-375 NPs were prepared by a reverse microemulsions method...
June 1, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28573278/a-luminescent-ratiometric-ph-sensor-based-on-a-nanoscale-and-biocompatible-eu-tb-mixed-mof
#17
Tifeng Xia, Fengliang Zhu, Ke Jiang, Yuanjing Cui, Yu Yang, Guodong Qian
The precise and real-time monitoring of localized pH changes is of great importance in many engineering and environmental fields, especially for monitoring small pH changes in biological environments and living cells. Metal-organic frameworks (MOFs) with their nanoscale processability show very promising applications in bioimaging and biomonitoring, but the fabrication of nanoscale MOFs is still a challenge. In this study, we synthesized a nanoscale mixed-lanthanide metal-organic framework by a microemulsion method...
June 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28571904/co-delivery-of-evodiamine-and-rutaecarpine-in-a-microemulsion-based-hyaluronic-acid-hydrogel-for-enhanced-analgesic-effects-on-mouse-pain-models
#18
Yong-Tai Zhang, Zhe Li, Kai Zhang, Hong-Yu Zhang, Ze-Hui He, Qing Xia, Ji-Hui Zhao, Nian-Ping Feng
The aim of this study was to improve the analgesic effect of evodiamine and rutaecarpine, using a microemulsion-based hydrogel (ME-Gel) as the transdermal co-delivery vehicle, and to assess hyaluronic acid as a hydrogel matrix for microemulsion entrapment. A microemulsion was formulated with ethyl oleate as the oil core to improve the solubility of the alkaloids and was loaded into a hyaluronic acid-structured hydrogel. Permeation-enhancing effects of the microemulsion enabled evodiamine and rutaecarpine in ME-Gel to achieve 2...
May 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28569515/self-emulsifying-drug-delivery-system-sedds-of-ibuprofen-formulation-in-vitro-and-in-vivo-evaluation
#19
Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy
The goal of the present study was to develop a self-emulsifying drug delivery system for the oral poorly water-soluble drug ibuprofen and to evaluate its oral bioavailability. Phase diagrams were constructed to determine the phase behaviour of the microemulsions and to compare the efficiency of various surfactant-oil mixtures. The SEDDS formulations of ibuprofen were prepared from a mixture of Labrafil M2125, Cremophor RH40, and Plurol oleique. The prepared emulsions were characterized for in vitro and in vivo behaviour...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28565943/an-analytical-gc-ms-method-to-quantify-methyl-dihydrojasmonate-in-biocompatible-oil-in-water-microemulsions-physicochemical-characterization-and-in-vitro-release-studies
#20
Gisela Bevilacqua Rolfsen Ferreira da Silva, Alberto Camilo Alécio, Maria Virginia Costa Scarpa, Eryvaldo Socrates Tabosa do Egito, Rodrigo Sequinel, Rafael Rodrigues Hatanaka, José Eduardo Oliveira, Anselmo Gomes de Oliveira
Microemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0...
June 21, 2017: Pharmaceutical Development and Technology
keyword
keyword
28415
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"