Elisabetta Esposito, Francesca Ferrara, Markus Drechsler, Olga Bortolini, Daniele Ragno, Sofia Toldo, Agnese Bondi, Alessandra Pecorelli, Rebecca Voltan, Paola Secchiero, Giorgio Zauli, Giuseppe Valacchi
The skin's protective mechanisms, in some cases, are not able to counteract the destructive effects induced by UV radiations, resulting in dermatological diseases, as well as skin aging. Nutlin-3, a potent drug with antiproliferative activity in keratinocytes, can block UV-induced apoptosis by activation of p53. In the present investigation, ethosomes and transethosomes were designed as delivery systems for nutlin-3, with the aim to protect the skin against UV damage. Vesicle size distribution was evaluated by photon correlation spectroscopy and morphology was investigated by cryogenic transmission electron microscopy, while nutlin-3 entrapment capacity was evaluated by ultrafiltration and HPLC...
January 21, 2024: Life