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https://www.readbyqxmd.com/read/28228078/nanocarriers-mediated-topical-drug-delivery-for-psoriasis-treatment
#1
Sevgi Güngör, Meriem Rezigue
BACKGROUND: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28228076/transdermal-drug-delivery-opportunities-and-challenges-for-controlled-delivery-of-therapeutic-agents-using-nanocarriers
#2
Balak Das Kurmi, Pawan Tekchandani, Rishi Paliwal, Shivani Rai Paliwal
BACKGROUND: Transdermal drug delivery represents an extremely attractive and innovative route across the skin owing to the possibility for achieving systemic effect of drugs. Present scenario demands a special focus on developing safe medicine with minimize toxic adverse effects related to most of the pharmacologically active agents. Transdermal drug delivery would be a focal paradigm which provides patient convenience, first-pass hepatic metabolism avoidance, local targeting and reduction in toxic effect related to various categories of drugs like, analgesics, anti-inflammatory, antibiotics, antiviral, anaesthetic, anticancer etc...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28163981/current-advances-in-5-aminolevulinic-acid-mediated-photodynamic-therapy
#3
Connor Thunshelle, Rui Yin, Qiquan Chen, Michael R Hamblin
Kennedy and Pottier discovered that photodynamic therapy (PDT) could be carried out using a procedure consisting of topical application of the porphyrin-precursor, 5-aminolevulinic acid (ALA) to the skin, followed after some time by illumination with various light parameters in the 1980s. Since then, ALA-PDT has expanded enormously and now covers most aspects of dermatological disease. The purpose of this review is to discuss a range of ingenious strategies that investigators have devised for improving the overall outcome (higher efficiency and lower side effects) of ALA-PDT...
September 2016: Current Dermatology Reports
https://www.readbyqxmd.com/read/28121196/nanoethosomes-for-transdermal-delivery-of-tropisetron-hcl-multi-factorial-predictive-modeling-characterization-and-ex-vivo-skin-permeation
#4
Hanaa A Abdel Messih, Rania A H Ishak, Ahmed S Geneidi, Samar Mansour
OBJECTIVE: The aim of the present work is to exclusively optimize and model the effect of phospholipid type either egg phosphatidylcholine (EPC) or soybean phosphatidylcholine (SPC), together with other formulation variables, on the development of nano-ethosomal systems for transdermal delivery of a water-soluble antiemetic drug. Tropisetron HCl (TRO) is available as hard gelatin capsules and IV injections. The transdermal delivery of TRO is considered as a novel alternative route supposing to improve BAV as well as patient convenience...
January 25, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28004261/the-therapy-with-ethosomes-containing-5-fluorouracil-for-laryngotracheal-stenosis-in-rabbit-models
#5
Xiaohui Mao, Xuefeng Cheng, Zheng Zhang, Zhaoyan Wang, Zhentao Wang
The aim of this study is to evaluate the efficacy of ethosomes encapsulated with 5-fluorouracil (5-FU) in treatment of laryngotracheal stenosis in rabbit models. The 5-FU ethosome was prepared by the thin film hydration method, and the amorphous, size distribution and the encapsulation efficiency was investigated. The tracheal mucosa were scraped about 0.5 cm with a nylon brush to induce the scar in airway grow, then models were divided into three groups: 5-FU ethosome group, 5-FU group and saline group, drug were injected into scar of every group by paracentesis guided under endoscope, respectively...
December 21, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27865609/recent-advances-in-lipid-based-vesicles-and-particulate-carriers-for-topical-and-transdermal-application
#6
REVIEW
Shashank Jain, Niketkumar Patel, Mansi K Shah, Pinak Khatri, Namrata Vora
In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery, and interest in life cycle management strategies among pharmaceutical companies. Literature review of recent publications indicates that among various skin delivery systems, lipid-based delivery systems (vesicular carriers and lipid particulate systems) have been the most successful. Vesicular carriers consist of liposomes, ultradeformable liposomes, and ethosomes, while lipid particulate systems consist of lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers...
February 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27832955/lipid-vesicular-nanocarrier-quick-encapsulation-efficiency-determination-and-transcutaneous-application
#7
Yibang Zhang, Weibeng Ng, Xue Feng, Fangying Cao, Huaxi Xu
Nanoscale delivery systems have been widely investigated to overcome the penetration barrier of stratum corneum for effective transcutaneous application. The aim of this study is the development of effective vesicular formulations of ovalbumin and saponin which are able to promote penetration through the skin layers. Three kinds of vesicular formulations have been investigated as carriers, including liposomes, transfersomes and ethosomes, in which cholesterol and/or cationic lipid stearylamine are incorporated...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27830857/5-aminolevulinic-acid-loaded-ethosomal-vesicles-with-high-entrapment-efficiency-for-in-vitro-topical-transdermal-delivery-and-photodynamic-therapy-of-hypertrophic-scars
#8
Zheng Zhang, Yunsheng Chen, Heng Xu, Yan Wo, Zhen Zhang, Ying Liu, Weijie Su, Daxiang Cui, Yixin Zhang
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative therapy for hypertrophic scars (HS), which destroys human hypertrophic scar fibroblasts (HSF). However, the poor permeability of ALA both in HS tissue and HSF significantly restricts the PDT of HS. To overcome these barriers, ALA-loaded ethosomal vesicles (ALA-ES) were developed by a pH gradient active loading method and characterized by morphology, entrapment efficiency (EE) and stability. Results show that prepared ALA-ES are homogenous spherical lamellar vesicles, 53 ± 7 nm in size, 50...
November 10, 2016: Nanoscale
https://www.readbyqxmd.com/read/27830454/ethosomes-and-organogels-for-cutaneous-administration-of-crocin
#9
Elisabetta Esposito, Markus Drechsler, Nicolas Huang, Gabriella Pavoni, Rita Cortesi, Debora Santonocito, Carmelo Puglia
The present study describes the production and characterization of phosphatidylcholine based ethosomes and organogels, as percutaneous delivery systems for crocin. Crocin presence did not influence ethosome morphology, while the drug slightly increased ethosome mean diameter. Importantly, the poor chemical stability of crocin has been found to be long controlled by organogel. To investigate the performance of phosphatidylcholine lipid formulations as crocin delivery system, in vivo studies, based on tape stripping and skin reflectance spectrophotometry, were performed...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27788607/investigating-the-penetrating-potential-of-nanocomposite-%C3%AE-cycloethosomes-development-using-central-composite-design-in-vitro-and-ex-vivo-characterization
#10
Nida Akhtar, Anurag Verma, Kamla Pathak
CONTEXT: Atopic dermatitis (AD) is a chronic skin disease characterized by inflammation of the skin and has exhibited remarkable repercussions on human life across the globe. Fluocinolone acetonide (FA), a topical corticosteroid is employed in the treatment of atopic dermatitis, but suffers from limited penetration into deeper epidermis of atopic skin. OBJECTIVE: The present investigation was focused to explore the utility of β-cylcoethosomes in improvising the penetration deep into the skin...
November 16, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27764711/comparative-assessment-of-lipid-based-nano-carrier-systems-for-dendritic-cell-based-targeting-of-tumor-re-initiating-cells-in-gynecological-cancers
#11
Arpit Bhargava, Dinesh K Mishra, Subodh K Jain, Rupesh K Srivastava, Nirmal K Lohiya, Pradyumna K Mishra
We aimed to identify an optimum nano-carrier system to deliver tumor antigen to dendritic cells (DCs) for efficient targeting of tumor reinitiating cells (TRICs) in gynecological malignancies. Different lipid based nano-carrier systems i.e. liposomes, ethosomes and solid lipid nanoparticles (SLNPs) were examined for their ability to activate DCs in allogeneic settings. Out of these three, the most optimized formulation was subjected for cationic and mannosylated surface modification and pulsed with DCs for specific targeting of tumor cells...
November 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27667097/enhanced-skin-deposition-and-delivery-of-voriconazole-using-ethosomal-preparations
#12
Waleed Faisal, Ghareb M Soliman, Ahmed M Hamdan
Despite its broad-spectrum antifungal properties, voriconazole has many side effects when administered systemically. The aim of this work was to develop an ethosomal topical delivery system for voriconazole and test its potential to enhance the antifungal properties and skin delivery of the drug. Voriconazole was encapsulated into various ethosomal preparations and the effect of phospholipid and ethanol concentrations on the ethosomes properties were evaluated. The ethosomes were evaluated for drug encapsulation efficiency, particle size and morphology and antifungal efficacy...
September 25, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27663228/recent-expansion-of-pharmaceutical-nanotechnologies-and-targeting-strategies-in-the-field-of-phytopharmaceuticals-for-the-delivery-of-herbal-extracts-and-bioactives
#13
REVIEW
Amit Alexander, Ajazuddin, Ravish J Patel, Swarnlata Saraf, Shailendra Saraf
Application of pharmaceutical nanotechnology (nanomedicines) for plant actives and extracts, is gaining a tremendous growth and interest among the scientists. This emerging herbal revolution has headed towards the development of another approaches for the delivery of poorly soluble herbal bioactives and plant extracts for enhancing their bioavailability and efficacy. In the same context, a majority of pharmaceutical nanotechnologies and targeting strategies including phytosomes, nanoparticles, hydrogels, microspheres, transferosomes and ethosomes, self nano emulsifying drug delivery systems (SNEDDS), self micro emulsifying drug delivery systems (SMEDDS) has been applied for the delivery of bioactives and plant extracts and were identified and explored...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27626605/ethosomal-curcumin-promoted-wound-healing-and-reduced-bacterial-flora-in-second-degree-burn-in-rat
#14
A Partoazar, N Kianvash, M H Darvishi, S Nasoohi, S M Rezayat, A Bahador
Background: Curcumin is well known in biomedical investigations with an extensive antimicrobial properties and wound repair effect. However, clinical criteria recommend curcumin should be formulated for topical medication. Material and method: In this study, we prepared Ethosomal curcumin (Etho-cur) formulation for wound healing and bacterial flora assessments in treated rats which were subjected to second degree burn under a standard procedure. Results: Applying once daily of Etho-cur (0.2%) topically on rat's dorsal for 14 days significantly recovered main aspects of wound repair including re-epithelization (P<0...
December 2016: Drug Research
https://www.readbyqxmd.com/read/27620074/transdermal-delivery-from-liposomal-formulations-evolution-of-the-technology-over-the-last-three-decades
#15
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes(®), ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27592075/drug-nanocarrier-the-future-of-atopic-diseases-advanced-drug-delivery-systems-and-smart-management-of-disease
#16
REVIEW
Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Haliza Katas, Tarek A Ahmed, Minaketan Tripathy, Jing Leng, Hua-Li Qin, Syed Nasir Abbas Bukhari
Atopic dermatitis (AD) is a chronically relapsing skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin-E (IgE), T-lymphocytes and mast cells. The key pathophysiological factors causing this disease are immunological disorders and the compromised epidermal barrier integrity. Pruritus, intense itching, psychological stress, deprived physical and mental performance and sleep disturbance are the hallmark features of this dermatological complication. Preventive interventions which include educational programs, avoidance of allergens, exclusive care towards skin, and the rational selection of therapeutic regimen play key roles in the treatment of dermatosis...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27526697/ethosomes-as-vesicles-for-effective-transdermal-delivery-from-bench-to-clinical-implementation
#17
Nida Akhtar, Anurag Verma, Kamla Pathak
BACKGROUND: Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. A number of efforts have been put forward to find ways to get therapeutic actives overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have been investigated for its potential where high proportion of ethanol enables them to ameliorate transdermal delivery of several drugs in comparison to other carriers...
August 13, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27441661/ethosomes-loaded-with-cryptotanshinone-for-acne-treatment-through-topical-gel-formulation
#18
Zhenwei Yu, Hongyan Lv, Gang Han, Ke Ma
The aim of this study was to develop ethosomes loaded with cryptotanshinone (CPT) and formulate them as a topical gel for the treatment of acne. Ethosomes were prepared and evaluated for vesicle size, CPT loading and encapsulation efficiency. Optimized ethosomes were formulated as Carbomer 974 gels and compared with conventional hydroethanolic gels for transdermal permeation and skin deposition in vitro. The anti-acne activity and skin irritation of the gel was investigated in rabbits. Optimized ethosomes had an average vesicle size of 69...
2016: PloS One
https://www.readbyqxmd.com/read/27429295/ethosomes-for-enhanced-skin-delivery-of-griseofulvin
#19
Joana Marto, Catarina Vitor, Ana Guerreiro, Cristiana Severino, Carla Eleutério, Andreia Ascenso, Sandra Simões
Griseofulvin (GRF) is an important antifungal drug with low bioavailability and, for this reason, a topical formulation with a targeted action and minimal systemic effects, appears to be a preferable solution. GRF poor solubility has limited the development of topical formulations and their release to the market. The aim of this work was to prepare a new GRF formulation for topical application using lipid-based nanosystems; to study its permeation and penetration, cell viability and to evaluate its therapeutic action...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27367965/feasibility-of-binary-composition-in-development-of-nanoethosomal-glycolic-vesicles-of-triamcinolone-acetonide-using-box-behnken-design-in-vitro-and-ex-vivo-characterization
#20
Nida Akhtar, Anurag Verma, Kamla Pathak
Triamcinolone acetonide (TA) employed for the treatment of atopic dermatitis exhibits limited penetration into the epidermis. This investigation aimed to explore the role of binary solvents in topical drug delivery of TA by developing nanoethosomal glycolic lipid vesicles by infusion method. Screening of vesicles (TA1-TA17) formulated by Box Behnken design identified the optimized formulation (TA10) that was developed as carbomer gels. The gels were then evaluated for pharmaceutical properties and compared with control and reference ethosomal gel (RG)...
July 1, 2016: Artificial Cells, Nanomedicine, and Biotechnology
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