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https://www.readbyqxmd.com/read/27863184/lipase-sensitive-transfersomes-based-on-photosensitizer-polymerizable-lipid-conjugate-for-selective-antimicrobial-photodynamic-therapy-of-acne
#1
Hyung Park, Jonghwan Lee, Songhee Jeong, Byeong Nam Im, Min-Kyoung Kim, Su-Geun Yang, Kun Na
Acne vulgaris is a common skin problem affecting nearly 90% of adolescents and its development is associated with a colonization of Propionibacterium acnes (P. acnes). Although antibiotics have commonly been used to treat acne, antibiotic resistance of P. acnes is an emerging issue to be solved. In this study, a new way of photodynamic acne therapy is developed using P. acnes lipase-sensitive transfersome (DSPE-PEG-Pheo A (DPP) transfersome). For enhanced selectivity and skin penetration efficiency, DPP transfersomes are prepared from 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000], pheophorbide A (Pheo A), cholesterol, and Tween-80...
November 10, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27832955/lipid-vesicular-nanocarrier-quick-encapsulation-efficiency-determination-and-transcutaneous-application
#2
Yibang Zhang, Weibeng Ng, Xue Feng, Fangying Cao, Huaxi Xu
Nanoscale delivery systems have been widely investigated to overcome the penetration barrier of stratum corneum for effective transcutaneous application. The aim of this study is the development of effective vesicular formulations of ovalbumin and saponin which are able to promote penetration through the skin layers. Three kinds of vesicular formulations have been investigated as carriers, including liposomes, transfersomes and ethosomes, in which cholesterol and/or cationic lipid stearylamine are incorporated...
November 8, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27778435/safety-and-efficacy-of-topical-ketoprofen-in-transfersome-gel-in-knee-osteoarthritis-a-systematic-review
#3
Vandit Sardana, Joanna Burzynski, Paul Zalzal
PURPOSE: Topical ketoprofen in Transfersome gel has been used for the alleviation of symptoms in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with various side effects. Topical NSAIDs are known to have a lower side-effect profile when compared with systemic administration. The present systematic review aimed to determine the safety and efficacy of topical ketoprofen in Transfersome gel in knee osteoarthritis (OA). METHODS: A systematic literature review was performed...
October 24, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27660724/improved-bioavailability-of-timolol-maleate-via-transdermal-transfersomal-gel-statistical-optimization-characterization-and-pharmacokinetic-assessment
#4
Nadia M Morsi, Ahmed A Aboelwafa, Marwa H S Dawoud
Timolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4 h; parameters necessitating its frequent administration. The current study was therefore, designed to formulate and optimize the transfersomal TiM gel for transdermal delivery. TiM loaded transfersomal gel was optimized using two 2(3) full factorial designs; where the effects of egg phosphatidyl choline (PC): surfactant (SAA) molar ratio, solvent volumetric ratio, and the drug amount were evaluated...
September 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27620464/composite-chitosan-transfersomal-vesicles-for-improved-transnasal-permeation-and-bioavailability-of-verapamil
#5
Mamdouh Abdel Mouez, Maha Nasr, Mona Abdel-Mottaleb, Ahmed S Geneidi, Samar Mansour
The creation of composite systems has become an emerging field in drug delivery. Chitosan has demonstrated several pharmaceutical advantages, especially in intranasal delivery. In this manuscript, a comparative study was conducted between regular vesicles (transfersomes and penetration enhancer vesicles) and composite vesicles (chitosan containing transfersomes and penetration enhancer vesicles) loaded with a model antihypertensive drug; verapamil hydrochloride VRP. Composite vesicles displayed larger particle size than regular vesicles owing to the coating potential of chitosan on the vesicular bilayer as displayed by transmission electron microscopy, with an increased viscosity of composite vesicles and a shift in the zeta potential values from negative to positive...
September 9, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27620074/transdermal-delivery-from-liposomal-formulations-evolution-of-the-technology-over-the-last-three-decades
#6
Mukul Ashtikar, Kalpa Nagarsekar, Alfred Fahr
Strong barrier properties of stratum corneum often limits the efficiency of drug delivery through skin. Several strategies were tried to improve permeation of drug through skin for local as well as systemic drug delivery. Incorporation of the drug within flexible liposomal vesicles has been one of the popular and well-studied approaches for delivering drug to deeper layers of the skin or even systemic circulation. Flexible/deformable/elastic liposomal systems such as invasomes, Transfersomes(®), ethosomes, niosomes, etc...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27526697/ethosomes-as-vesicles-for-effective-transdermal-delivery-from-bench-to-clinical-implementation
#7
Nida Akhtar, Anurag Verma, Kamla Pathak
BACKGROUND: Drug delivery across the deeper layers of skin to make it systemically available is a considerable challenge in the development of a carrier. A number of efforts have been put forward to find ways to get therapeutic actives overcome the formidable barrier of stratum corneum. Various lipid based vesicles viz liposomes, transfersomes, and invasomes have gained prominent deliberations across the globe. More recently, ethosomes have been investigated for its potential where high proportion of ethanol enables them to ameliorate transdermal delivery of several drugs in comparison to other carriers...
August 13, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27422107/needle-free-jet-injection-of-intact-phospholipid-vesicles-across-the-skin-a-feasibility-study
#8
Michele Schlich, Francesco Lai, Sergio Murgia, Donatella Valenti, Anna Maria Fadda, Chiara Sinico
Needle-free liquid jet injectors are devices developed for the delivery of pharmaceutical solutions through the skin. In this paper, we investigated for the first time the ability of these devices to deliver intact lipid vesicles. Diclofenac sodium loaded phospholipid vesicles of two types, namely liposomes and transfersomes, were prepared and fully characterized. The lipid vesicles were delivered through a skin specimen using a jet injector and the collected samples were analyzed to assess vesicle structural integrity, drug retention and release kinetics after the injection...
August 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27352543/-optimization-of-formulation-of-panax-notoginseng-saponins-transfersomes
#9
Cui Chang, Si-si Chen, Hong-tu Yang, Hang-sheng Zheng
OBJECTIVE: To optimize the formulation of Panax notoginseng saponins (PNS) transfersomes. METHODS: PNS transfersomes were prepared by film hydration-dispersion process. Based on the entrapment efficiency (EE) of ginsenoside Rg1 and ginsenoside Rb1, the effects of formulated quantity of sodium deoxycholate and cholesterol, the relative ion strength and pH value of hydration liquid were investigated. The formulation of PNS transfersomes were optimized by single-factor experiment and uniform design experiment...
December 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/27349691/preparation-of-osthole-loaded-nano-vesicles-for-skin-delivery-characterization-in-vitro-skin-permeation-and-preliminary-in-vivo-pharmacokinetic-studies
#10
Shu Meng, Chong Zhang, Wei Shi, Xiao-Wei Zhang, Dan-Hua Liu, Ping Wang, Jian-Xin Li, Ying Jin
The main objective of the present research was to evaluate the flexible nano-vesicles for transdermal delivery of osthole. The nano-vesicles were formulated, characterized and evaluated for their physicochemical properties, in vitro skin permeation and in vivo plasma concentration. The encapsulation efficiency of osthole in ethosome and transfersome was measured to be 83.3±4.8% and 80.9±3.6%, respectively. In vitro studies showed that osthole ethosome provided an enhanced transdermal flux of 6.98±1.6μg/cm(2)/h and a decreased lag time of 2...
September 20, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27274231/current-application-of-phytocompound-based-nanocosmeceuticals-for-beauty-and-skin-therapy
#11
REVIEW
Palanivel Ganesan, Dong-Kug Choi
Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27270718/erratum-to-transfersomal-nanoparticles-for-enhanced-transdermal-delivery-of-clindamycin
#12
Ahmed A H Abdellatif, Hesham M Tawfeek
No abstract text is available yet for this article.
December 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27199229/ethosomes-and-transfersomes-principles-perspectives-and-practices
#13
Varun Garg, Harmanpreet Singh, Sneha Bimbrawh, Sachin Kumar Singh, Monica Gulati, Yogyata Vaidya, Prabhjot Kaur
The success story of liposomes in the treatment of systemic infectious diseases and various carcinomas lead the scientists to the innovation of elastic vesicles to achieve similar success through transdermal route. In this direction, ethosomes and transfersomes were developed with the objective to design the vesicles that could pass through the skin. Both these delivery systems have proven themselves as promising carriers to transport drugs across skin. Both these elastic nanocarriers offer unique advantages of ferrying the drug across membranes, sustaining drug release as well as protecting the encapsulated bio actives from external environment...
May 20, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27193030/lipid-based-vesicular-nanocargoes-as-nanotherapeutic-targets-for-the-effective-management-of-rheumatoid-arthritis
#14
Mahfoozur Rahman, Sarwar Beg, Gajanand Sharma, Sumant Saini, Rehan A Rub, Preeti Aneja, Firoz Anwar, Mohammad A Alam, Vikas Kumar
BACKGROUND: Rheumatoid arthritis (RA) is an immune mediated joint-based chronic inflammatory disorder recognized by joint inflammation, destruction, pain and remission. Currently, numerous pharmacotherapeutic strategies have gained immense popularity in RA therapy and improving the patient life. METHODS: Besides, it exhibits numerous drawbacks such as requirement of high dose of drugs, unavoidable adverse effects and diseases remission. Thus, use of currently available pharmacotherapeutics employing conventional formulations can only provide therapeutic effects to a certain extent...
2016: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/27165164/current-status-of-ethosomes-and-elastic-liposomes-in-dermal-and-transdermal-drug-delivery
#15
Kevin Ita
It is still not clear whether intact lipid vesicles can cross the human skin. Some reports in the literature indicate that transfersomes® can cross the skin. Other reports suggest that intact liposomes cannot cross the skin. Of course, the composition of the various formulations has to be taken into consideration before making such assertions. The present review examines the use of vesicles- elastic liposomes and ethosomes- for transdermal drug delivery. Liposomes are micro- or nano-structures formed from a bilayer of lipid surrounding an aqueous core...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27123418/aggregated-nanotransfersomal-dry-powder-inhalation-of-itraconazole-for-pulmonary-drug-delivery
#16
Mehdi Hassanpour Aghdam, Saeed Ghanbarzadeh, Yousef Javadzadeh, Hamed Hamishehkar
PURPOSE: Local therapy is a valuable and strategic approach in the treatment of lung associated diseases and dry powder inhalation (DPI) formulations play the key role in this plan. Transfersome has been introduced as a novel biocompatible vesicular system with potential for administration in pulmonary drug delivery. The present study was designed to prepare Itraconazole-loaded nanotrantransfersomal DPI formulation. METHODS: Itraconazole-loaded nanotransfersomes with three different types of surfactant in varying concentrations were prepared and characterized in the point of particle size distribution and morphology by laser light scattering and scanning electron microscopy (SEM) methods...
March 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27103786/optimized-nano-transfersomal-films-for-enhanced-sildenafil-citrate-transdermal-delivery-ex-vivo-and-in-vivo-evaluation
#17
Shaimaa M Badr-Eldin, Osamaa Aa Ahmed
Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and, more recently, for other indications, including pulmonary hypertension. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. Thus, the objective of this work is to formulate optimized SLD nano-transfersomal transdermal films with enhanced and controlled permeation aiming at surmounting the previously mentioned challenges and hence improving the drug bioavailability...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27020331/combined-mixture-process-variable-approach-a-suitable-statistical-tool-for-nanovesicular-systems-optimization
#18
Basant A Habib, Mohamed H H AbouGhaly
OBJECTIVES: This study aims to illustrate the applicability of combined mixture-process variable (MPV) design and modeling for optimization of nanovesicular systems. METHODS: The D-optimal experimental plan studied the influence of three mixture components (MCs) and two process variables (PVs) on lercanidipine transfersomes. The MCs were phosphatidylcholine (A), sodium glycocholate (B) and lercanidipine hydrochloride (C), while the PVs were glycerol amount in the hydration mixture (D) and sonication time (E)...
June 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27005227/enhanced-transdermal-lymphatic-drug-delivery-of-hyaluronic-acid-modified-transfersome-for-tumor-metastasis-therapy
#19
Lin Hou, Ming Kong
No abstract text is available yet for this article.
September 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26981839/deformability-properties-of-timolol-loaded-transfersomes-based-on-the-extrusion-mechanism-statistical-optimization-of-the-process
#20
M L González-Rodríguez, C M Arroyo, M J Cózar-Bernal, P L González-R, J M León, M Calle, D Canca, A M Rabasco
The purpose of this work was to analyze the deformability properties of different timolol maleate (TM)-loaded transfersomes by extrusion. This was performed because elastic liposomes may contribute to the elevation of amount and rate of drug permeation through the corneal membrane. This paper describes the optimization of a transfersome formulation by use of Taguchi orthogonal experimental design and two different statistical analysis approaches were utilized. The amount of cholesterol (F1), the amount of edge-activator (F2), the distribution of the drug into the vesicle (F3), the addition of stearylamine (F4) and the type of edge-activator (F5) were selected as causal factors...
October 2016: Drug Development and Industrial Pharmacy
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