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https://www.readbyqxmd.com/read/29158713/formulation-and-characterization-of-novel-soft-nanovesicles-for-enhanced-transdermal-delivery-of-eprosartan-mesylate
#1
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the present work was to formulate, optimize and evaluate the potential of novel soft nanovesicles i.e. nano-transfersomes, containing eprosartan mesylate (EM) for transdermal delivery. Nano-transfersomes of EM were developed using Phospholipon 90G, Span 80 (SP) and sodium deoxycholate (SDC) and characterized for vesicle size, shape, entrapment efficiency, in vitro skin permeation study and confocal laser scanning microscopy. The optimized nano-transfersomes formulation showed vesicles size of 108...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29146539/hyaluronan-decorated-liposomes-as-drug-delivery-systems-for-cutaneous-administration
#2
Silvia Franzé, Alessandro Marengo, Barbara Stella, Paola Minghetti, Silvia Arpicco, Francesco Cilurzo
The work aimed to evaluate the feasibility to design hyaluronic acid (HA) decorated flexible liposomes to enhance the skin penetration of nifedipine. Egg phosphatidylcholine (e-PC) based transfersomes (Tween 80) and transethosomes (ethanol) were prepared. HA was reacted with 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (HA-DPPE) and two molar ratios (0.5 and 3%) of conjugate with respect to e-PC were tested. The presence of HA significantly increased the packing order of the bilayer (as verified by differential scanning calorimetry), reducing both the encapsulation efficiency and the flexibility of the decorated liposomes in a dose-dependent manner...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29124986/development-of-zolmitriptan-transfersomes-by-box-behnken-design-for-nasal-delivery-in-vitro-and-in-vivo-evaluation
#3
Sravan Kumar Pitta, Narendar Dudhipala, Arjun Narala, Kishan Veerabrahma
The aim was to prepare an optimized zolmitriptan (ZT) loaded transfersome formulation using Box-Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal spray. Here, three factors were evaluated at three levels. Independent variables include: amount of soya lecithin (X1), amount of drug (X2) and amount of tween 80 (X3). The dependent responses were vesicle size (Y1), flexibility index (Y2) and regression co-efficient of drug release kinetics (Y3)...
November 10, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29111097/lipid-nanocarriers-as-skin-drug-delivery-systems-properties-mechanisms-of-skin-interactions-and-medical-applications
#4
REVIEW
M Sala, R Diab, A Elaissari, H Fessi
During the past decades, lipid nanocarriers are gaining momentum with their multiple advantages for the management of skin diseases. Lipid nanocarriers enable to target the therapeutic payload to deep skin layers or even to reach the blood circulation making them a promising cutting-edge technology. Lipid nanocarriers refer to a large panel of drug delivery systems. Lipid vesicles are the most conventional, known to be able to carry lipophilic and hydrophilic active agents. A variety of lipid vesicles with high flexibility and deformability could be obtained by adjusting their composition; namely ethosomes, transfersomes and penetration enhancer lipid vesicles which achieve the best results in term of skin permeation...
October 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29061106/potential-enhancement-and-targeting-strategies-of-polymeric-and-lipid-based-nanocarriers-in-dermal-drug-delivery
#5
Emine Kahraman, Sevgi Güngör, Yıldız Özsoy
Nanocarriers used for alternative drug-delivery strategies have gained interest due to improved penetration and delivery of drugs into specific regions of the skin in recent years. Dermal drug delivery via polymeric-based nanocarriers (polymeric nanoparticles, micelles, dendrimers) and lipid-based nanocarriers (solid-lipid nanoparticles and nanostructured lipid carriers, vesicular nanocarriers including liposomes, niosomes, transfersomes and ethosomes) has been widely investigated. Although penetration of nanocarriers through the intact skin could be restricted, these carriers are particularly considered as feasible for the treatment of dermatological diseases in which the skin barrier is disrupted and also for follicular delivery of drugs for management of skin disorders such as acne...
November 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28990515/recent-advances-and-perspectives-in-liposomes-for-cutaneous-drug-delivery
#6
Amanda C Caritá, Josimar O Eloy, Marlus Chorilli, Robert J Lee, Gislaine Ricci Leonardi
The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28977352/the-optimized-hplc-method-for-quantitative-analysis-of-phenylethyl-resorcinol-loaded-in-the-novel-vesicle-carriers-and-permeated-in-in-vitro-skin-permeation-study
#7
Tunyaluk Limsuwan, Prapaporn Boonme, Thanaporn Amnuaikit
The high performance liquid chromatography (HPLC) was used for quantitative determination of phenylethyl resorcinol (PR) which was loaded in the novel vesicle carriers including ethosome, invasome and transfersome formulations, and permeated into pig skin membrane and receptor fluid for skin permeation study. The reverse-phase chromatography was carried out with a C18 column (150 × 4.6 mm2, 5 μm, HypersilTM, Thermo Fisher Scientific Inc, USA) with the column temperature at 25°C. A mixture of acetonitrile-methanol-Milli-Q water in the ratio of 40:20:40%, v/v/v was used as a mobile phase by maintaining the flow rate at 0...
November 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28943208/preparation-of-mixed-monoterpenes-edge-activated-pegylated-transfersomes-to-improve-the-in-vivo-transdermal-delivery-efficiency-of-sinomenine-hydrochloride
#8
Juan Wang, Yan Wei, Ya-Rong Fei, Li Fang, Hang-Sheng Zheng, Chao-Feng Mu, Fan-Zhu Li, Yong-Sheng Zhang
Surfactants generally have been used as edge activators of transfersomes. However, surfactants edge activated transfersomes frequently lead to cutaneous irritation, skin lipid loss and other side effects after dermal administration. In this study, mixed monoterpenes edge activated PEGylated transfersomes (MMPTs) were prepared by ethanol injection process with sinomenine hydrochloride as a model drug. The formulation of MMPTs was optimized by an orthogonal design. We investigated skin permeation/deposition characteristics and pharmacokinetics of sinomenine hydrochloride loaded in MMPTs by comparing with liposomes using in vitro skin tests and in vivo cutaneous microdialysis...
November 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28925887/design-optimize-and-characterize-granisetron-hcl-loaded-nano-gel-for-transdermal-delivery
#9
Vikash Kumar, Hema Chaudhary, Geeta Aggarwal
The aim of study was to design, statistically optimize and characterize Granisetron HCl loaded transfersomal gel for transdermal delivery, in order to overcome the side effects associated with oral delivery. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipid-90G, sodium deoxycholate and sonication time, each at three levels, were selected as independent variables, and while entrapment efficiency, vesicle size and transdermal flux were identified as dependent variables...
September 15, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28739792/transfersomal-phage-cocktail-is-an-effective-treatment-against-methicillin-resistant-staphylococcus-aureus-mediated-skin-and-soft-tissue-infections
#10
Sanjay Chhibber, Ashu Shukla, Sandeep Kaur
The emergence of drug resistance has rekindled interest in phage therapy as an alternative treatment option; its potency, safety, and proven efficacy are worth noting. However, phage therapy still suffers from issues of poor stability, narrow spectra, and poor pharmacokinetic profiles. Therefore, it is essential to look into the use of drug delivery systems for efficient delivery of lytic phages in vivo The present study evaluated the use of nanostructured lipid-based carriers, i.e., transfersomes, as transdermal delivery systems for encapsulating a methicillin-resistant Staphylococcus aureus (MRSA) phage cocktail...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625748/comparison-of-liposomal-drug-formulations-for-transdermal-iontophoretic-drug-delivery
#11
K Malinovskaja-Gomez, S Espuelas, M J Garrido, J Hirvonen, T Laaksonen
This study was aimed to evaluate the in vitro transdermal direct/pulsed current iontophoretic delivery of an amphiphilic model compound from various lipid vesicle-encapsulated formulations compared to free-drug formulation. Conventional, pegylated, ultradeformable liposomes (transfersomes) and ethosomes loaded with a negatively charged drug diclofenac sodium (DS) were prepared and characterized. All the liposomes possessed an average size of ≈100-150nm and negative zeta potential. No changes in colloidal stability were detected after 8h incubation of any vesicle formulation under constant or pulsed iontophoretic current...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28504046/formulation-and-characterization-of-phospholipon-90%C3%A2-g-and-tween-80-based-transfersomes-for-transdermal-delivery-of-eprosartan-mesylate
#12
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the current study was to formulate the eprosartan mesylate loaded transfersomes using different proportions of Phospholipon(®) 90 G and Tween(®) 80 (95-75:5-25% w/w). The prepared transfersomes were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy, and in vivo skin irritation. Results revealed that the formulated transfersomes were negatively charged, spherical unilamellar structure of 71...
May 26, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28480758/loratadine-bioavailability-via-buccal-transferosomal-gel-formulation-statistical-optimization-in-vitro-in-vivo-characterization-and-pharmacokinetics-in-human-volunteers
#13
Mohammed H Elkomy, Shahira F El Menshawe, Heba A Abou-Taleb, Marwa H Elkarmalawy
Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel for transbuccal delivery of LTD. Transfersomes bearing LTD were prepared by conventional thin film hydration method and optimized using sequential Quality-by-Design approach that involved Placket-Burman design for screening followed by constrained simplex-centroid design for optimization of a Tween-80/Span-60/Span-80 mixture...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28279741/enhanced-non-invasive-trans-tympanic-delivery-of-ciprofloxacin-through-encapsulation-into-nano-spanlastic-vesicles-fabrication-in-vitro-characterization-and-comparative-ex-vivo-permeation-studies
#14
Abdulaziz Mohsen Al-Mahallawi, Omneya Mohammed Khowessah, Raguia Ali Shoukri
The aim of this research was to encapsulate ciprofloxacin, a broad spectrum fluoroquinolone antibiotic, into Span 60 based nano-elastic vesicles, nano-spanlastics, for accomplishing improved non invasive trans-tympanic delivery, providing means for ototopical treatment of acute otitis media (AOM). To achieve this purpose, ciprofloxacin-loaded nano-spanlastics were prepared by thin film hydration (TFH) technique, using several non-ionic edge activators (EAs) according to full factorial design (3(2)). The investigation of the effect of formulation variables on nano-spanlastic characteristics and selection of the optimum formula were performed using Design-Expert(®) software...
April 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28264602/enhancement-of-the-bioavailability-of-an-antihypertensive-drug-by-transdermal-protransfersomal-system-formulation-and-in-vivo-study
#15
Nadia M Morsi, Ahmed A Aboelwafa, Marwa H S Dawoud
Timolol Maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from poor oral bioavailability (50%) due to its first pass effect and a short elimination half-life of 4 h; resulting in its frequent administration. Transdermal formulation may circumvent these problems in the form of protransfersomes. The aim of this study is to develop and optimize transdermal protransfersomal system of Timolol Maleate by film deposition on carrier method where protransfersomes were converted to transfersomes upon skin hydration following transdermal application under occlusive conditions...
March 6, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28237913/pharmacodynamic-study-of-eprosartan-mesylate-loaded-transfersomes-carbopol-%C3%A2-gel-under-dermaroller-%C3%A2-on-rats-with-methyl-prednisolone-acetate-induced-hypertension
#16
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of present study was to prepare eprosartan mesylate (EM)-loaded transfersomes Carbopol(®) gel and characterized for various parameters, including in vitro skin permeation, in vivo antihypertensive study, skin irritation, and histological study. Furthermore, effect of transfersomes gel on angiotensin II type-1 receptor (AT1R) mRNA and protein expressions on smooth vascular muscles of aorta was determined by real-time polymerase chain reaction (RT-PCR) and western blot analysis. The physical evaluation parameters were detected to be in correspondence with reference marketed gel formulation...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28228078/nanocarriers-mediated-topical-drug-delivery-for-psoriasis-treatment
#17
Sevgi Güngör, Meriem Rezigue
BACKGROUND: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28156169/nanotransfersomes-loaded-thermosensitive-in-situ-gel-as-a-rectal-delivery-system-of-tizanidine-hcl-preparation-in-vitro-and-in-vivo-performance
#18
Fatma A Moawad, Adel A Ali, Heba F Salem
The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent used for treatment of spasticity) loaded nanotransfersomes intended for rectal administration, aiming to bypass the hepatic first-pass metabolism. TIZ-loaded nanotransfersomes were prepared by thin-film hydration method followed by characterization for various parameters including entrapment efficiency, vesicle diameter, in vitro release and ex vivo permeation studies. Transfersomal formulation composed of phosphatidylcholine and Tween 80 at a weight ratio of (85:15) gave a satisfactory results...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28155509/skin-delivery-of-epigallocatechin-3-gallate-egcg-and-hyaluronic-acid-loaded-nano-transfersomes-for-antioxidant-and-anti-aging-effects-in-uv-radiation-induced-skin-damage
#19
COMPARATIVE STUDY
Kiran S Avadhani, Jyothsna Manikkath, Mradul Tiwari, Misra Chandrasekhar, Ashok Godavarthi, Shimoga M Vidya, Raghu C Hariharapura, Guruprasad Kalthur, Nayanabhirama Udupa, Srinivas Mutalik
The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization. They were characterized with respect to size, polydispersity index, zeta potential, morphology, entrapment efficiency, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), in vitro antioxidant activity and ex vivo skin permeation studies...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28050929/development-and-optimization-of-apigenin-loaded-transfersomal-system-for-skin-cancer-delivery-in-vitro-evaluation
#20
Manmohan Singh Jangdey, Anshita Gupta, Shailendra Saraf, Swarnlata Saraf
The aim of this work is to apply Box-Behnken design to optimize the transfersomes were formulated by modified rotary evaporation sonication technique using surfactant Tween 80. The response surface methodology was used having three-factored with three levels. The prepared formulations were characterized for vesicle shape, size, entrapment efficiency (%), stability, and in vitro permeation. The result showed that drug entrapment of 84.24% with average vesicle size of 35.41 nm and drug loading of 8.042%. Thus, optimized formulation was found good stability and is a promising approach to improve the permeability of apigenin in sustained release for prolonged period of time...
January 4, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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