keyword
MENU ▼
Read by QxMD icon Read
search

transfersomes

keyword
https://www.readbyqxmd.com/read/29407555/enhanced-transdermal-delivery-of-ondansetron-using-nanovesicular-systems-fabrication-characterization-optimization-and-ex-vivo-permeation-study-box-cox-transformation-practical-example
#1
Basant A Habib, Sinar Sayed, Ghada M Elsayed
This study aimed to formulate suitable nanovesicles (NVs) for transdermal delivery of Ondansetron. It also illustrated a practical example for the importance of Box-Cox transformation. A 23 full factorial design was used to enable testing transfersomes, ethosomes, and transethosomes of Ondansetron simultaneously. The independent variables (IVs) studied were sodium taurocholate amount, ethanol volume in hydration medium and sonication time. The studied dependent variables (DVs) were: particle size (PS), zeta potential (ZP) and entrapment efficiency (EE)...
January 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29384060/nanocarrier-based-advances-in-drug-delivery-to-tumor-an-overview
#2
Ankit Jain, Romi Kumari, Ankita Tiwari, Amit Verma, Amita Tripathi, Akanksha Shrivastava, Sanjay K Jain
BACKGROUND: Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in the 1-100 nm size regime in at least one dimension. OBJECTIVE: Nanotechnology in drug delivery has been evidenced into nanocarriers that possess distinct properties both in vitro and in vivo, which may be used in targeting drugs to various diseases especially tumors...
January 30, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29374518/in-vitro-stabilization-and-in-vivo-improvement-of-ocular-pharmacokinetics-of-the-multi-therapeutic-agent-baicalin-delineating-the-most-suitable-vesicular-systems
#3
Orchid Ashraf, Maha Nasr, Marianne Nebsen, Azza Mohamed Ahmed Said, Omaima Sammour
Baicalin is a multi-purpose flavonoid used in the treatment of different ocular diseases. Owing to its poor stability in basic pH and its poor solubility, a suitable carrier system is needed to enhance its ocular therapeutic potential. Therefore, the objective of this work was to prepare and contrast different baicalin vesicular systems; namely liposomes, penetration enhancer vesicles PEVs and transfersomes. Results revealed that baicalin vesicles exhibited suitable particle size and zeta potential, high entrapment efficiency and controlled release...
January 24, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29318970/physicochemical-characterization-and-skin-permeation-of-cationic-transfersomes-containing-the-synthetic-peptide-pnpp-19
#4
Flavia De Marco Almeida, Carolina Nunes Silva, Savia Caldeira de Araujo Lopes, Daniel Moreira Santos, Fernanda Silva Torres, Felipe Lima Cardoso, Patricia Massara Martinelli, Elizabeth Ribeiro da Silva, Maria Elena de Lima, Lucas Antonio Ferreira Miranda, Monica Cristina Oliveira
BACKGROUND: PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE: The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded transfersomes. METHOD: Three different liposomal preparation methods were evaluated. Cationic transfersomes contained egg phosphatidyl choline: stearylamine (9:1 w/w) and Tween 20 (84...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29318969/confronting-penetration-threshold-via-fluidic-terpenoid-nanovesicles
#5
Kamla Pathak, Ankur Vaidya, Vijay Sharma
BACKGROUND: Improvisation of the nanosized vesicular systems has led to a series of useful developments including the deformable vesicles namely transfersomes, ethosomes and invasomes. While the former two have been explored extensively, literature on invasomes is relatively scanty. METHOD: Invasomal formulations researched for various applications have been reviewed using search engine "Scopus". The present review focuses on the update on the research activity on effectiveness and permeation enhancing effects of invasomes for dermal and topical delivery...
January 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29248674/nanodesign-of-new-self-assembling-core-shell-gellan-transfersomes-loading-baicalin-and-in-vivo-evaluation-of-repair-response-in-skin
#6
Maria Manconi, Maria Letizia Manca, Carla Caddeo, Donatella Valenti, Claudia Cencetti, Octavio Diez-Sales, Amparo Nacher, Silvia Mir-Palomo, Maria Carmen Terencio, Davide Demurtas, Juan Carmelo Gomez-Fernandez, Francisco José Aranda, Anna Maria Fadda, Pietro Matricardi
Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~ 24mPa/s) as compared to transfersomes (~ 1.6mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses...
December 14, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29158713/formulation-and-characterization-of-novel-soft-nanovesicles-for-enhanced-transdermal-delivery-of-eprosartan-mesylate
#7
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the present work was to formulate, optimize and evaluate the potential of novel soft nanovesicles i.e. nano-transfersomes, containing eprosartan mesylate (EM) for transdermal delivery. Nano-transfersomes of EM were developed using Phospholipon 90G, Span 80 (SP) and sodium deoxycholate (SDC) and characterized for vesicle size, shape, entrapment efficiency, in vitro skin permeation study and confocal laser scanning microscopy. The optimized nano-transfersomes formulation showed vesicles size of 108...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29146539/hyaluronan-decorated-liposomes-as-drug-delivery-systems-for-cutaneous-administration
#8
Silvia Franzé, Alessandro Marengo, Barbara Stella, Paola Minghetti, Silvia Arpicco, Francesco Cilurzo
The work aimed to evaluate the feasibility to design hyaluronic acid (HA) decorated flexible liposomes to enhance the skin penetration of nifedipine. Egg phosphatidylcholine (e-PC) based transfersomes (Tween 80) and transethosomes (ethanol) were prepared. HA was reacted with 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (HA-DPPE) and two molar ratios (0.5 and 3%) of conjugate with respect to e-PC were tested. The presence of HA significantly increased the packing order of the bilayer (as verified by differential scanning calorimetry), reducing both the encapsulation efficiency and the flexibility of the decorated liposomes in a dose-dependent manner...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29124986/development-of-zolmitriptan-transfersomes-by-box-behnken-design-for-nasal-delivery-in-vitro-and-in-vivo-evaluation
#9
Sravan Kumar Pitta, Narendar Dudhipala, Arjun Narala, Kishan Veerabrahma
The aim was to prepare an optimized zolmitriptan (ZT) loaded transfersome formulation using Box-Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal spray. Here, three factors were evaluated at three levels. Independent variables include: amount of soya lecithin (X1), amount of drug (X2) and amount of tween 80 (X3). The dependent responses were vesicle size (Y1), flexibility index (Y2) and regression co-efficient of drug release kinetics (Y3)...
November 10, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29111097/lipid-nanocarriers-as-skin-drug-delivery-systems-properties-mechanisms-of-skin-interactions-and-medical-applications
#10
REVIEW
M Sala, R Diab, A Elaissari, H Fessi
During the past decades, lipid nanocarriers are gaining momentum with their multiple advantages for the management of skin diseases. Lipid nanocarriers enable to target the therapeutic payload to deep skin layers or even to reach the blood circulation making them a promising cutting-edge technology. Lipid nanocarriers refer to a large panel of drug delivery systems. Lipid vesicles are the most conventional, known to be able to carry lipophilic and hydrophilic active agents. A variety of lipid vesicles with high flexibility and deformability could be obtained by adjusting their composition; namely ethosomes, transfersomes and penetration enhancer lipid vesicles which achieve the best results in term of skin permeation...
October 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29061106/potential-enhancement-and-targeting-strategies-of-polymeric-and-lipid-based-nanocarriers-in-dermal-drug-delivery
#11
Emine Kahraman, Sevgi Güngör, Yıldız Özsoy
Nanocarriers used for alternative drug-delivery strategies have gained interest due to improved penetration and delivery of drugs into specific regions of the skin in recent years. Dermal drug delivery via polymeric-based nanocarriers (polymeric nanoparticles, micelles, dendrimers) and lipid-based nanocarriers (solid-lipid nanoparticles and nanostructured lipid carriers, vesicular nanocarriers including liposomes, niosomes, transfersomes and ethosomes) has been widely investigated. Although penetration of nanocarriers through the intact skin could be restricted, these carriers are particularly considered as feasible for the treatment of dermatological diseases in which the skin barrier is disrupted and also for follicular delivery of drugs for management of skin disorders such as acne...
November 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28990515/recent-advances-and-perspectives-in-liposomes-for-cutaneous-drug-delivery
#12
Amanda C Caritá, Josimar O Eloy, Marlus Chorilli, Robert J Lee, Gislaine Ricci Leonardi
The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. In this review, we aimed to discuss key aspects for the topical delivery by drug-loaded liposomes. Phospholipid type and phase transition temperature have been shown to affect liposomal topical delivery...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28977352/the-optimized-hplc-method-for-quantitative-analysis-of-phenylethyl-resorcinol-loaded-in-the-novel-vesicle-carriers-and-permeated-in-in-vitro-skin-permeation-study
#13
Tunyaluk Limsuwan, Prapaporn Boonme, Thanaporn Amnuaikit
The high performance liquid chromatography (HPLC) was used for quantitative determination of phenylethyl resorcinol (PR) which was loaded in the novel vesicle carriers including ethosome, invasome and transfersome formulations, and permeated into pig skin membrane and receptor fluid for skin permeation study. The reverse-phase chromatography was carried out with a C18 column (150 × 4.6 mm2, 5 μm, HypersilTM, Thermo Fisher Scientific Inc, USA) with the column temperature at 25°C. A mixture of acetonitrile-methanol-Milli-Q water in the ratio of 40:20:40%, v/v/v was used as a mobile phase by maintaining the flow rate at 0...
November 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28943208/preparation-of-mixed-monoterpenes-edge-activated-pegylated-transfersomes-to-improve-the-in-vivo-transdermal-delivery-efficiency-of-sinomenine-hydrochloride
#14
Juan Wang, Yan Wei, Ya-Rong Fei, Li Fang, Hang-Sheng Zheng, Chao-Feng Mu, Fan-Zhu Li, Yong-Sheng Zhang
Surfactants generally have been used as edge activators of transfersomes. However, surfactants edge activated transfersomes frequently lead to cutaneous irritation, skin lipid loss and other side effects after dermal administration. In this study, mixed monoterpenes edge activated PEGylated transfersomes (MMPTs) were prepared by ethanol injection process with sinomenine hydrochloride as a model drug. The formulation of MMPTs was optimized by an orthogonal design. We investigated skin permeation/deposition characteristics and pharmacokinetics of sinomenine hydrochloride loaded in MMPTs by comparing with liposomes using in vitro skin tests and in vivo cutaneous microdialysis...
November 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28925887/design-optimize-and-characterize-granisetron-hcl-loaded-nano-gel-for-transdermal-delivery
#15
Vikash Kumar, Hema Chaudhary, Geeta Aggarwal
The aim of study was to design, statistically optimize and characterize Granisetron HCl loaded transfersomal gel for transdermal delivery, in order to overcome the side effects associated with oral delivery. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipid-90G, sodium deoxycholate and sonication time, each at three levels, were selected as independent variables, and while entrapment efficiency, vesicle size and transdermal flux were identified as dependent variables...
September 15, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28739792/transfersomal-phage-cocktail-is-an-effective-treatment-against-methicillin-resistant-staphylococcus-aureus-mediated-skin-and-soft-tissue-infections
#16
Sanjay Chhibber, Ashu Shukla, Sandeep Kaur
The emergence of drug resistance has rekindled interest in phage therapy as an alternative treatment option; its potency, safety, and proven efficacy are worth noting. However, phage therapy still suffers from issues of poor stability, narrow spectra, and poor pharmacokinetic profiles. Therefore, it is essential to look into the use of drug delivery systems for efficient delivery of lytic phages in vivo The present study evaluated the use of nanostructured lipid-based carriers, i.e., transfersomes, as transdermal delivery systems for encapsulating a methicillin-resistant Staphylococcus aureus (MRSA) phage cocktail...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625748/comparison-of-liposomal-drug-formulations-for-transdermal-iontophoretic-drug-delivery
#17
K Malinovskaja-Gomez, S Espuelas, M J Garrido, J Hirvonen, T Laaksonen
This study was aimed to evaluate the in vitro transdermal direct/pulsed current iontophoretic delivery of an amphiphilic model compound from various lipid vesicle-encapsulated formulations compared to free-drug formulation. Conventional, pegylated, ultradeformable liposomes (transfersomes) and ethosomes loaded with a negatively charged drug diclofenac sodium (DS) were prepared and characterized. All the liposomes possessed an average size of ≈100-150nm and negative zeta potential. No changes in colloidal stability were detected after 8h incubation of any vesicle formulation under constant or pulsed iontophoretic current...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28504046/formulation-and-characterization-of-phospholipon-90%C3%A2-g-and-tween-80-based-transfersomes-for-transdermal-delivery-of-eprosartan-mesylate
#18
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the current study was to formulate the eprosartan mesylate loaded transfersomes using different proportions of Phospholipon(®) 90 G and Tween(®) 80 (95-75:5-25% w/w). The prepared transfersomes were characterized for their vesicles size, shape, polydispersity index, zeta potential, entrapment efficiency, in vitro skin permeation, confocal laser scanning microscopy, and in vivo skin irritation. Results revealed that the formulated transfersomes were negatively charged, spherical unilamellar structure of 71...
May 26, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28480758/loratadine-bioavailability-via-buccal-transferosomal-gel-formulation-statistical-optimization-in-vitro-in-vivo-characterization-and-pharmacokinetics-in-human-volunteers
#19
Mohammed H Elkomy, Shahira F El Menshawe, Heba A Abou-Taleb, Marwa H Elkarmalawy
Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption. This study was undertaken to develop and statistically optimize transfersomal gel for transbuccal delivery of LTD. Transfersomes bearing LTD were prepared by conventional thin film hydration method and optimized using sequential Quality-by-Design approach that involved Placket-Burman design for screening followed by constrained simplex-centroid design for optimization of a Tween-80/Span-60/Span-80 mixture...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28279741/enhanced-non-invasive-trans-tympanic-delivery-of-ciprofloxacin-through-encapsulation-into-nano-spanlastic-vesicles-fabrication-in-vitro-characterization-and-comparative-ex-vivo-permeation-studies
#20
Abdulaziz Mohsen Al-Mahallawi, Omneya Mohammed Khowessah, Raguia Ali Shoukri
The aim of this research was to encapsulate ciprofloxacin, a broad spectrum fluoroquinolone antibiotic, into Span 60 based nano-elastic vesicles, nano-spanlastics, for accomplishing improved non invasive trans-tympanic delivery, providing means for ototopical treatment of acute otitis media (AOM). To achieve this purpose, ciprofloxacin-loaded nano-spanlastics were prepared by thin film hydration (TFH) technique, using several non-ionic edge activators (EAs) according to full factorial design (3(2)). The investigation of the effect of formulation variables on nano-spanlastic characteristics and selection of the optimum formula were performed using Design-Expert(®) software...
April 30, 2017: International Journal of Pharmaceutics
keyword
keyword
28412
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"