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mixed micelles

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https://www.readbyqxmd.com/read/28929997/seasonal-variation-in-the-composition-and-processing-characteristics-of-herd-milk-with-varying-proportions-of-milk-from-spring-calving-and-autumn-calving-cows
#1
Yingchen Lin, James A O'Mahony, Alan L Kelly, Timothy P Guinee
The study investigated the seasonal changes in the compositional, physicochemical and processing characteristics of milk from a mixed-herd of spring- and autumn-calving cows during the year 2014-2015. The volume proportion of autumn-calving milk (% of total milk) varied with season, from ~10-20 in Spring (March-May), 5-13 in Summer (June-August), 20-40 in Autumn (September-November) and 50-100 in Winter (December-February). While all characteristics varied somewhat from month to month, variation was inconsistent, showing no significant trend with progression of time (year)...
September 20, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28919756/polymeric-mixed-micelles-loaded-mitoxantrone-for-overcoming-multidrug-resistance-in-breast-cancer-via-photodynamic-therapy
#2
Zeyong Li, Yuee Cai, Yiqiao Zhao, Hua Yu, Haiyu Zhou, Meiwan Chen
Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(d,l-lactide-co-glycolide)-poly(ethylene glycol)-poly(d,l-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28903185/mixed-micelles-for-encapsulation-of-doxorubicin-with-enhanced-in-vitro-cytotoxicity-on-breast-and-ovarian-cancer-cell-lines-versus-doxil-%C3%A2
#3
Maximiliano Cagel, Ezequiel Bernabeu, Lorena Gonzalez, Eduardo Lagomarsino, Marcela Zubillaga, Marcela A Moretton, Diego A Chiappetta
Doxorubicin (DOX) is used as a "first-line" antineoplastic drug in ovarian and metastatic breast cancer. However, serious side effects, such as cardiotoxicity have been reported after DOX intravenous administration. Hence, we investigated different micelle-former biomaterials, as Soluplus(®), Pluronic F127, Tetronic T1107 and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) to develop a potential mixed micellar nanocarrier for DOX delivery. Since DOX hydrochloride is a poor candidate to be encapsulated inside the hydrophobic core of the mixed micelles, we assayed a hydrophobic complex between DOX and sodium deoxycholate (NaDC) as an excellent candidate to be encapsulated within polymeric micelles...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28895250/co2-induced-morphological-transition-of-co-assemblies-from-block-random-segmented-polymers
#4
Hongyao Yin, Wei Wang, Meng Mu, Yujun Feng
The co-assembly process is an effective approach to construct hierarchically nanostructured soft materials, but morphological transition of co-assemblies upon external stimuli, particularly the "green" trigger CO2 , is not unraveled yet. Here, a segmented copolymer, poly(styrene)-block-poly[(4-vinyl pyridine)-random-((2-(diethylamino)ethyl methacrylate)] (P1), is used to co-assemble in the mixed solvent of dimethyl formamide and water with poly(ethylene oxide)-block-poly[(4-vinyl pyridine)-random-((2-(diethylamino)ethyl methacrylate)] (P2) and poly(ethylene oxide)-block-poly(acrylic acid) (P3), respectively...
September 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28891984/in-vitro-sonodynamic-therapeutic-effect-of-polyion-complex-micelles-incorporating-titanium-dioxide-nanoparticles
#5
Satoshi Yamamoto, Masafumi Ono, Eiji Yuba, Atsushi Harada
Titanium dioxide nanoparticles (TiO₂ NPs) can act as sonosensitizers, generating reactive oxygen species under ultrasound irradiation, for use in sonodynamic therapy. For TiO₂ NPs delivery, we prepared polyion complex micelles incorporating TiO₂ NPs (TiO₂ NPs-PIC micelles) by mixing TiO₂ NPs with polyallylamine bearing poly(ethylene glycol) grafts. In this study, the effects of polymer composition and ultrasound irradiation conditions on the sonodynamic therapeutic effect toward HeLa cells were evaluated experimentally using cell viability evaluation, intracellular distribution observation, and a cell staining assay...
September 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28881202/the-effect-of-solvent-polarity-on-wormlike-micelles-using-dipropylene-glycol-dpg-as-a-cosolvent-in-an-anionic-zwitterionic-mixed-surfactant-system
#6
Hanqiu Jiang, Gregory Beaucage, Karsten Vogtt, Michael Weaver
HYPOTHESIS: The behavior/properties of micellar solutions are governed by Coulombic interactions that are influenced by the polarity of the surfactant head groups, hydrophobic tails, and solvent molecules. The addition of co-solvent should have a direct impact on solvent polarity and the size of the micelles are expected to decrease accordingly. EXPERIMENTS: In this study, a mixed surfactant system is studied composed of a common anionic surfactant, sodium laureth sulfate-1, modified by a zwitterionic surfactant, cocamidopropyl betaine in deuterated water...
August 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28878397/physical-and-pharmacokinetic-characterizations-of-trans-resveratrol-t-rev-encapsulated-with-self-assembling-lecithin-based-mixed-polymeric-micelles-salmpms
#7
Tzu-Pin Li, Wan-Ping Wong, Ling-Chun Chen, Chia-Yu Su, Lih-Geeng Chen, Der-Zen Liu, Hsiu-O Ho, Ming-Thau Sheu
This study involved physical and pharmacokinetic characterizations of trans-resveratrol (t-Rev)-loaded saLMPMs which attempted to improve t-Rev's pharmacokinetic profiles and bioavailability resolving hurdles limiting its potential health benefits. The optimal formulation consisted of t-Rev, lecithin, and Pluronic(®) P123 at 5:2:20 (t-Rev-loaded PP123 saLMPMs) provided mean particle size <200 nm, encapsulation efficiency >90%, and drug loading >15%. Compared to t-Rev solubilized with HP-β-CD, t-Rev-loaded PP123 saLMPMs enhanced t-Rev's stability in PBS at RT, 4 °C, and 37 °C and in FBS at 37 °C, and retarded the in vitro release...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860753/ph-sensitive-and-folic-acid-targeted-mpeg-phis-fa-peg-ve-mixed-micelles-for-the-delivery-of-ptx-ve-and-their-antitumor-activity
#8
Yan Di, Ting Li, Zhihong Zhu, Fen Chen, Lianqun Jia, Wenbing Liu, Xiumei Gai, Yingying Wang, Weisan Pan, Xinggang Yang
The aim of this study was to simultaneously introduce pH sensitivity and folic acid (FA) targeting into a micelle system to achieve quick drug release and to enhance its accumulation in tumor cells. Paclitaxel-(+)-α-tocopherol (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene glycol) methyl ether-poly(histidine) (MPEG-PHIS) and folic acid-poly(ethylene glycol)-(+)-α-tocopherol (FA-PEG-VE) were characterized by dynamic light scattering and transmission electron microscopy (TEM). The mixed micelles had a spherical morphology with an average diameter of 137...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28841376/triblock-co-polymer-assisted-mixed-micelle-formation-results-in-the-refolding-of-unfolded-protein
#9
Ramakanta Mondal, Narayani Ghosh, Bijan Kumar Paul, Saptarshi Mukherjee
The present work reports a new strategy for triblock copolymer assisted refolding of Sodium Dodecyl Sulfate (SDS) induced unfolded serum protein Human Serum Albumin (HSA) by mixed-micelle formation of SDS with the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer EO20PO68EO20 (P123) under physiological conditions. The steady-state and time-resolve fluorescence results show that the unfolding of HSA induced by SDS occurs by a step wise manner through three different phases of binding of SDS which is followed by a saturation of interaction...
August 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28832153/impact-of-surface-active-ionic-liquids-on-the-cloud-points-of-nonionic-surfactants-and-the-formation-of-aqueous-micellar-two-phase-systems
#10
Filipa A Vicente, Inês S Cardoso, Tânia E Sintra, Jesus Lemus, Eduardo F Marques, Sónia P M Ventura, João A P Coutinho
Aqueous micellar two-phase systems (AMTPS) hold a large potential for cloud point extraction of biomolecules but are yet poorly studied and characterized, with few phase diagrams reported for these systems, hence limiting their use in extraction processes. This work reports a systematic investigation of the effect of different surface-active ionic liquids (SAILs)-covering a wide range of molecular properties-upon the clouding behavior of three nonionic Tergitol surfactants. Two different effects of the SAILs on the cloud points and mixed micelle size have been observed: ILs with a more hydrophilic character and lower critical packing parameter (CPP < (1)/2) lead to the formation of smaller micelles and concomitantly increase the cloud points; in contrast, ILs with a more hydrophobic character and higher CPP (CPP ≥ 1) induce significant micellar growth and a decrease in the cloud points...
September 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28817259/sub-20-nm-stable-micelles-based-on-a-mixture-of-coiled-coils-a-platform-for-controlled-ligand-presentation
#11
JooChuan Ang, Dan Ma, Benson T Jung, Sinan Keten, Ting Xu
Ligand-functionalized, multivalent nanoparticles have been extensively studied for biomedical applications from imaging agents to drug delivery vehicles. However, the ligand cluster size is usually heterogeneous and the local valency is ill-defined. Here, we present a mixed micelle platform hierarchically self-assembled from a mixture of two amphiphilic 3-helix and 4-helix peptide-polyethylene glycol (PEG)-lipid hybrid conjugates. We demonstrate that the local multivalent ligand cluster size on the micelle surface can be controlled based on the coiled-coil oligomeric state...
September 5, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28806698/fluorescence-and-electron-paramagnetic-resonance-studies-of-norfloxacin-and-n-donor-mixed-ligand-ternary-copper-ii-complexes-stability-and-interaction-with-sds-micelles
#12
Gabriel S Vignoli Muniz, Jimmy Llontop Incio, Odivaldo C Alves, Klaus Krambrock, Letícia R Teixeira, Sonia R W Louro
The stability of ternary copper(II) complexes of a heterocyclic ligand, L (L being 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen)) and the fluorescent antibacterial agent norfloxacin (NFX) as the second ligand was studied at pH7.4 and different ionic strengths. Fluorescence quenching upon titration of NFX with the binary complexes allowed to obtain stability constants for NFX binding, Kb, as a function of ionic strength. The Kb values vary by more than two orders of magnitude when buffer concentration varies from 0...
August 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28800463/combination-of-dexamethasone-and-avastin-%C3%A2-by-supramolecular-hydrogel-attenuates-the-inflammatory-corneal-neovascularization-in-rat-alkali-burn-model
#13
Jinhai Huang, Wenwen Wang, Jing Yu, Xinxin Yu, Qianqian Zheng, Fangli Peng, Zhifen He, Wenguang Zhao, Zhaoliang Zhang, Xingyi Li, Qinmei Wang
Corneal neovascularization (CNV) is one of the leading causes of vision loss and a high-risk factor for transplant rejection. The present study proposed a supramolecular hydrogel comprised of MPEG-PCL micelles and α-cyclodextrin (α-CD) for co-delivery of dexamethasone sodium phosphate (Dexp) and Avastin(®) (Ava), and further evaluated its therapeutic efficacy in rat alkali burn model. A physical mixing of Dexp/Ava, MPEG-PCL micelles, and α-CD aqueous solution leads to a spontaneous formation of the supramolecular hydrogel via a "host-guest" recognition between MPEG and α-CD...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28782782/thermodynamic-stability-of-worm-like-micelle-solutions
#14
Karsten Vogtt, Gregory Beaucage, Michael Weaver, Hanqiu Jiang
Worm-like micelles (WLMs) are nano-scale self-assemblies widely used for viscosity enhancement, for drug delivery, and in personal care products. The stability of WLMs under variable ionic and surfactant concentrations is important to applications of these fascinating materials. In this work it is demonstrated that a virial approach can be used to understand and predict WLM stability. A mixed surfactant system consisting of sodium laureth sulfate and cocoamidopropyl betaine was examined using small-angle neutron scattering...
September 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28766653/controllable-multicompartment-morphologies-from-cooperative-self-assembly-of-copolymer-copolymer-blends
#15
Zhikun Wang, Shuangqing Sun, Chunling Li, Songqing Hu, Roland Faller
Multicompartment nanostructures, such as microcapsules with clearly separated shell and core, are not easily accessible by conventional block copolymer self-assembly. We assess a versatile computational strategy through cooperative assembly of diblock copolymer blends to generate spherical and cylindrical compartmentalized micelles with intricate structures and morphologies. The co-assembly strategy combines the advantages of polymer blending and incompatibility-induced phase separation. Following this strategy, various nanoassemblies of pure AB, binary AB/AC and ternary AB/AC/AD systems such as compartmentalized micelles with sponge-like, Janus, capsule-like and onion-like morphologies can be obtained...
September 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/28766643/the-inter-micellar-interaction-enthalpies-of-dtab-tx100-mixed-micelles-and-their-structural-transitions
#16
Handi Yin, Peizhu Zheng, Jihua Zhao, Weiguo Shen
The heats of mixing for a series of DTAB/TX100 mixed surfactant aqueous solutions were measured by flow-mixing calorimetry and isothermal titration calorimetry (ITC) at 298.15 K and 85 kPa, which were used to calculate the inter-micellar interaction enthalpies (-ΔHC). The signs of -ΔHC for pure DTAB and TX100 micellar systems were contrary to the inter-micellar interaction parameters reported for the same systems in the literature, suggesting that these interaction parameters might have a Gibbs free energy character dominated by entropy changes...
September 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/28749696/influence-of-physiological-gastrointestinal-surfactant-ratio-on-the-equilibrium-solubility-of-bcs-class-ii-drugs-investigated-using-a-four-component-mixture-design
#17
Zhou Zhou, Claire Dunn, Ibrahim Khadra, Clive G Wilson, Gavin W Halbert
The absorption of poorly water-soluble drugs is influenced by the luminal gastrointestinal fluid content and composition, which control solubility. Simulated intestinal fluids have been introduced into dissolution testing including endogenous amphiphiles and digested lipids at physiological levels; however, in vivo individual variation exists in the concentrations of these components, which will alter drug absorption through an effect on solubility. The use of a factorial design of experiment and varying media by introducing different levels of bile, lecithin, and digested lipids has been previously reported, but here we investigate the solubility variation of poorly soluble drugs through more complex biorelevant amphiphile interactions...
August 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28744122/penetration-of-blood-brain-barrier-and-antitumor-activity-and-nerve-repair-in-glioma-by-doxorubicin-loaded-monosialoganglioside-micelles-system
#18
Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang, Yazhou Wang
For the treatment of glioma and other central nervous system diseases, one of the biggest challenges is that most therapeutic drugs cannot be delivered to the brain tumor tissue due to the blood-brain barrier (BBB). The goal of this study was to construct a nanodelivery vehicle system with capabilities to overcome the BBB for central nervous system administration. Doxorubicin as a model drug encapsulated in ganglioside GM1 micelles was able to achieve up to 9.33% loading efficiency and 97.05% encapsulation efficiency by orthogonal experimental design...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28741924/ultrasound-responsive-polymeric-micelles-for-sonoporation-assisted-site-specific-therapeutic-action
#19
Pengying Wu, Yali Jia, Fei Qu, Yue Sun, Pan Wang, Kun Zhang, Chuanshan Xu, Quanhong Liu, Xiaobing Wang
Targeting drug delivery remains a challenge in various disease treatment including cancer. The local drug deposit could be greatly enhanced by some external stimuli-responsive systems. Here we develop pluronic P123/F127 polymeric micelles (M) encapsulating curcumin (Cur) that are permeabilized directly by focused ultrasound, in which ultrasound triggers drug release. Tumor preferential accumulation and site-specific sonochemotherapy were then evaluated. Cur-loaded P123/F127 mixed micelles (Cur-M) exhibited longer circulating time and increased cellular uptake compared to free Cur...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28739210/bile-salt-stimulated-lipase-inhibition-by-phospholipids-and-relief-by-phospholipase-a2
#20
Elena Venuti, Dmitry Shishmarev, Philip W Kuchel, Shoma Dutt, Caron S Blumenthal, Kevin J Gaskin
INTRODUCTION: Bile salt stimulated lipase (BSSL; Enzyme Commission (EC) number 3.1.1.13) has been a candidate triglyceridase for improving enzyme therapy for pancreatic insufficiency; however, its efficacy is near absent. We hypothesise that similarly to pancreatic lipase, BSSL is inhibited by phospholipids and this inhibition is relieved by Phospholipase A2 (PLA2; EC 3.1.1.4), and the present study was undertaken to explore this possibility. MATERIALS AND METHODS: Synthetic emulsions of triglyceride and phosphatidylcholine (PC) or lysophosphatidylcholine (LPC)/bile salt mixed micelles were used as a model of intestinal digestion-media...
July 21, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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