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mixed micelles

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https://www.readbyqxmd.com/read/28719220/egfr-targeted-cationic-polymeric-mixed-micelles-for-co-delivery-of-gemcitabine-and-mir-205-for-treating-advanced-pancreatic-cancer
#1
Goutam Mondal, Saud Almawash, Amit Kumar Chaudhary, Ram I Mahato
Gemcitabine (GEM), a first-line chemotherapy for pancreatic cancer undergoes rapid metabolism and develops chemoresistance after repeated administration. We previously demonstrated that the combination of GEM and miR-205 provides an effective therapeutic strategy to sensitize GEM-resistant pancreatic cancer cells. Since epidermal growth factor receptor (EGFR) is overexpressed in pancreatic cancer cells, in this study, we aimed to deliver mixed micelles containing GEM and miR-205 decorated with EGFR-targeting cetuximab (C225) monoclonal antibody for targeted therapy...
July 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28718278/matrix-stiffness-differentially-regulates-cellular-uptake-behavior-of-nanoparticles-in-two-breast-cancer-cell-lines
#2
Yu Wang, Tao Gong, Zhirong Zhang, Yao Fu
Matrix stiffness regulates cell behavior in various biological contexts. In breast tumors, the deposition of extracellular matrix (ECM) correlates with increasing matrix stiffness and poor survival. Nanoparticulate carriers represent a promising therapeutic vehicle for disease diagnosis and efficient anticancer drug delivery. However, how matrix stiffness influences cellular uptake of nanoparticle remains largely unexplored. Here, we selected photopolymerized polyacrylamide gels with varying stiffness as model substrates, and studied the impact of matrix stiffness on cell morphology, nanoparticle uptake efficiency in two representative breast cancer cell lines with varying invasiveness, i...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28682629/biodegradable-strain-promoted-click-hydrogels-for-encapsulation-of-drug-loaded-nanoparticles-and-sustained-release-of-therapeutics
#3
Robert J Ono, Ashlynn L Z Lee, Zhi Xiang Voo, Shrinivas Venkataraman, Bei Wei Koh, Yi Yan Yang, James L Hedrick
Biodegradable polycarbonate-based ABA triblock copolymers were synthesized via organocatalyzed ring-opening polymerization and successfully formulated into chemically cross-linked hydrogels by strain-promoted alkyne-azide cycloaddition (SPAAC). The synthesis and cross-linking of these polymers are copper-free, thereby eliminating the concern over metallic contaminants for biomedical applications. Gelation occurs rapidly within a span of 60 s by simple mixing of the azide- and cyclooctyne-functionalized polymer solutions...
July 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28680187/composition-of-surface-layer-at-the-water-air-interface-and-micelles-of-triton-x-100%C3%A2-%C3%A2-rhamnolipid-mixtures
#4
Diana Mańko, Anna Zdziennicka, Bronisław Jańczuk
Measurements of the surface tensions, densities and viscosities of aqueous solutions of Triton X-100 (TX-100) and rhamnolipid (RL) mixtures, at constant concentration of RL or TX-100, were carried out. The measured values of the surface tension were compared to those determined using different theoretical models and on the basis of the surface tension of aqueous solutions of individual surfactants. From the surface tension isotherms, the Gibbs surface excess concentration of TX-100 and RL, the composition of surface layer and the standard Gibbs free energy of adsorption at the water-air interface were determined...
2017: Journal of Solution Chemistry
https://www.readbyqxmd.com/read/28678638/polysialic-acid-and-pluronic-f127-mixed-polymeric-micelles-of-docetaxel-as-new-approach-for-enhanced-antitumor-efficacy
#5
Ting Zhang, Songlei Zhou, Yang Liu, Xiang Luo, Donghua Di, Yanzhi Song, Xinrong Liu, Yihui Deng
In our previous study, polysialic acid-octadecyl dimethyl betaine (PSA-BS18) was synthesized and modified liposomal EPI. Preliminary experiments revealed that the PSA-BS18 was a potential material for targeting tumor site with superior curative effects. In this study, PSA-BS18 and Pluronic F127 (F127) mixed polymeric micelles encapsulated docetaxel (DTX) (FP/DTX) were prepared by a self-assembly method. The FP/DTX was found to have a diameter of 34.83 ± 0.50 nm with a narrow polydispersity, the entrapment efficiency was 99...
July 5, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28676872/precipitating-polyelectrolyte-surfactant-systems-by-admixing-a-nonionic-surfactant-a-case-of-cononsurfactancy
#6
Leonardo Chiappisi, Stephen David Leach, Michael Gradzielski
The formation of water insoluble polyelectrolyte/surfactant complexes (PESCs) upon mixing two homogeneous polycation/anionic surfactant and polycation/nonionic surfactant solutions is reported here. This phase separation is unexpected and differs markedly from the commonly observed enhanced solubility of colloidal systems in mixed surfactant systems. The study was performed on mixtures of the cationic biopolysaccharide chitosan (poly d-glucosamine) and mixed micelles composed of an ethoxylated fatty alcohol and its carboxylic acid terminated equivalent...
July 5, 2017: Soft Matter
https://www.readbyqxmd.com/read/28673668/impact-of-thermooxidation-of-phytosteryl-and-phytostanyl-fatty-acid-esters-on-cholesterol-micellarization-in-vitro
#7
Birgit Scholz, Renate Weiherer, Karl-Heinz Engel
The effects of thermooxidation of a phytosteryl/-stanyl and a phytostanyl fatty acid ester mixture on cholesterol micellarization were investigated using an in vitro digestion model simulating enzymatic hydrolysis by cholesterol esterase and subsequent competition of the liberated phytosterols/-stanols with cholesterol for incorporation into mixed micelles. As a first step, relationships between different doses of the ester mixtures and the resulting micellarized cholesterol were established. Subsequent subjection of the thermooxidized ester mixtures to the in vitro digestion model resulted in three principal observations: (i) thermal treatment of the ester mixtures led to substantial decreases of the intact esters, (ii) in vitro digestion of cholesterol in the presence of the thermooxidized ester mixtures resulted in significant increases of cholesterol micellarization, and (iii) the extents of the observed effects on cholesterol micellarization were strongly associated to the remaining contents of intact esters...
June 30, 2017: Steroids
https://www.readbyqxmd.com/read/28668220/modulation-of-protein-function-in-membrane-mimetics-characterization-of-p-denitrificans-cnor-in-nanodiscs-or-liposomes
#8
Josy Ter Beek, Maximilian Kahle, Pia Ädelroth
For detailed functional characterization, membrane proteins are usually studied in detergent. However, it is becoming clear that detergent micelles are often poor mimics of the lipid environment in which these proteins function. In this work we compared the catalytic properties of the membrane-embedded cytochrome c-dependent nitric oxide reductase (cNOR) from Paracoccus (P.) denitrificans in detergent, lipid/protein nanodiscs, and proteoliposomes. We used two different lipid mixtures, an extract of soybean lipids and a defined mix of synthetic lipids mimicking the original P...
June 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28661146/thermoresponsive-segments-retard-the-formation-of-equilibrium-micellar-interpolyelectrolyte-complexes-by-detouring-to-various-intermediate-structures
#9
Claudia Dähling, Gudrun Lotze, Hideharu Mori, Dmitry V Pergushov, Felix A Plamper
The kinetics of interpolyelectrolyte complexation involving architecturally complex (star-like) polymeric components is addressed. Specifically, the spontaneous coupling of branched cationic star-shaped miktoarm polymers, i.e., quaternized poly(ethylene oxide)114-(poly(2-(dimethylamino)ethyl methacrylate)17)4 (PEO114-(qPDMAEMA17)4), and temperature-sensitive linear anionic diblock copolymers poly(vinyl sulfonate)31-b-poly(N-isopropylacrylamide)27 (PVS31-b-PNIPAM27) and further rearrangements of the formed complexes were investigated by means of stopped-flow small-angle X-ray scattering (SAXS)...
June 29, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28648579/release-mechanism-of-doxazosin-from-carrageenan-matrix-tablets-effect-of-ionic-strength-and-addition-of-sodium-dodecyl-sulphate
#10
Petra Kos, Matej Pavli, Saša Baumgartner, Ksenija Kogej
The polyelectrolyte matrix tablets loaded with an oppositely charged drug exhibit complex drug-release mechanisms. In this study, the release mechanism of a cationic drug doxazosin mesylate (DM) from matrix tablets based on an anionic polyelectrolyte λ-carrageenan (λ-CARR) is investigated. The drug release rates from λ-CARR matrices are correlated with binding results based on potentiometric measurements using the DM ion-sensitive membrane electrode and with molecular characteristics of the DM-λ-CARR-complex particles through hydrodynamic size measurements...
June 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28648521/ratiometric-co-delivery-of-multiple-chemodrugs-in-a-single-nanocarrier
#11
Chao Chen, Ran Tao, Dan Ding, Deling Kong, Aiping Fan, Zheng Wang, Yanjun Zhao
Co-delivery of multiple anti-cancer drugs in a single nanoplatform has shown great promise in enhancing therapeutic efficacy and reducing adverse effects. However, the ratiometric dose control is pivotal, but often challenging in combinational nanomedicine. Here, we report the employment of cyclodextrin-bearing amphiphilic polymer conjugate micelles for ratiometric, non-covalent loading of three hydrophobic model drugs, curcumin (CUR), camptothecin (CPT), and doxorubicin (DOX) in one single nanocarrier. Each drug was physically encapsulated in the cyclodextrin-bearing polymer conjugate via guest-host complexation...
June 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28637416/mixed-micelles-as-nano-polymer-therapeutics-of-docetaxel-increased-in-vitro-cytotoxicity-and-decreased-in-vivo-toxicity
#12
Arehalli S Manjappa, Popat S Kumbhar, Prajakta S Khopade, Ajit B Patil, John I Disouza
Docetaxel (DTX) has been used to treat several types of cancers, but it has provided pharmaceutical challenges due to its poor water solubility and toxicities associated with the co-solvents (tween-80 and ethanol). Nanopolymer therapeutics can be engineered to deliver anticancer agent specifically to cancer cells, thereby leaving normal healthy cells unaffected by toxic drugs such as DTX. The objective of the present study was to synthesize the polyacrylic acid (PAA)-DTX conjugate (PAADC) and preparation of nanopolymer therapeutics such as PAADC/DSPE-mPEG2000 mixed micelles (PAADC-DP MMs)...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28628836/an-affinity-based-aqueous-two-phase-mixed-micellar-system-and-its-purification-of-yeast-3-5-bisphosphate-nucleotidase
#13
Yao Liu, Mei-Hao Sun, Shi-Kuan Shao, Gang Deng
Aqueous two-phase micellar system (ATPMS), as an alternative liquid-liquid extraction technique, has been extensively exploited for the precise separation or large-scale concentration of biomolecules. In this article, a novel affinity-based ATPMS composed of mixed micelles was constructed by introducing a Copper-chelated Triton X-114 (TX-Cu(II)) into an aqueous solution of hydrophobically modified ethylene oxide polymer (HM-EO). Phase diagram of the HM-EO/TX-Cu(II) system was measured, and the partitioning behavior of model proteins (YND, BSA, lysozyme) were studied by using this new system...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28628835/low-frequency-sonic-waves-assisted-cloud-point-extraction-of-polyhydroxyalkanoate-from-cupriavidus-necator
#14
Sivananth Murugesan, Regupathi Iyyaswami
Low frequency sonic waves, less than 10kHz were introduced to assist cloud point extraction of polyhydroxyalkanoate from Cupriavidus necator present within the crude broth. Process parameters including surfactant system variables and sonication parameters were studied for their effect on extraction efficiency. Introduction of low frequency sonic waves assists in the dissolution of microbial cell wall by the surfactant micelles and release of cellular content, polyhydroxyalkanoate granules released were encapsulated by the micelle core which was confirmed by crotonic acid assay...
June 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28627869/effects-of-detergent-micelles-on-lipid-binding-to-proteins-in-electrospray-ionization-mass-spectrometry
#15
Michael Landreh, Joana Costeira-Paulo, Joseph Gault, Erik G Marklund, Carol V Robinson
A wide variety of biological processes rely upon interactions between proteins and lipids, ranging from molecular transport to the organization of the cell membrane. It was recently established that electrospray ionization mass spectrometry (ESI-MS) is capable of capturing transient interactions between membrane proteins and their lipid environment, and a detailed understanding of the underlying processes is therefore of high importance. Here, we apply ESI-MS to investigate the factors that govern complex formation in solution and gas phases by comparing nonselective lipid binding with soluble and membrane proteins...
July 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28627562/a-novel-combined-chemical-kinetic-and-trapping-method-for-probing-the-relationships-between-chemical-reactivity-and-interfacial-h2o-br-and-h-ion-molarities-in-ctab-c12e6-mixed-micelles
#16
Aijaz Ahmad Dar, Laurence S Romsted, Nighat Nazir, Yongliang Zhang, Xiang Gao, Qing Gu, Changyao Liu
A delicate balance-of-forces governs the interactions responsible for surfactant self-assembly and chemical reactivity within them. Chemical reactions in micellar media generally occur in the interfacial region of micelles that is a complex mixture of: water, headgroups, counterions, co-ions, acids or bases, organic solvents, and the reactants themselves. We have carried out a detailed study of a complex chemical reaction in mixed CTAB/C12E6 micelles by using the chemical kinetic (CK) and chemical trapping (CT) methods...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28603959/characterization-of-complex-polymer-self-assemblies-and-large-aggregates-by-multidetector-thermal-field-flow-fractionation
#17
Upenyu L Muza, Guilaume Greyling, Harald Pasch
Micelles prepared from amphiphilic block copolymers (ABCs) have found numerous applications in pharmaceutical, electronics, environmental, cosmetics, and hygiene industries. These micelles, whether in the pure or mixed micelle form, often exist as multiple morphologies (spherical, cylindrical, worm, or vesicular) in equilibrium with each other. However, none of the current column-based fractionation techniques or any microscopic technique are capable of a successful separation, identification, and quantitation of these complex self-assemblies with regards to morphology, size, molar mass, and chemical composition in one experiment...
June 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28594018/biodegradable-injectable-polymer-systems-exhibiting-a-longer-and-controllable-duration-time-of-the-gel-state
#18
Yasuyuki Yoshida, Hiroki Takai, Keisuke Kawahara, Shintaro Mitsumune, Kazuyuki Takata, Akinori Kuzuya, Yuichi Ohya
Here, we report biodegradable temperature-triggered covalent gelation systems exhibiting a longer and controllable duration time of the gel state by a "mixing strategy" utilizing a thiol-ene reaction. We synthesized a tri-block copolymer of poly(caprolactone-co-glycolic acid) and PEG (tri-PCG) as a temperature-responsive injectable polymer (IP) and attached acryloyl groups on both termini (tri-PCG-Acryl). A tri-PCG micelle solution containing hydrophobic hexa-functional polythiol (Solution-A) and a tri-PCG-Acryl micelle solution (Solution-B) were mixed together...
June 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28592843/pluronic-f127-and-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-tpgs-mixed-micelles-for-targeting-drug-delivery-across-the-blood-brain-barrier
#19
Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB). Rhodamine 123 (Rho123) and DiR loaded mixed micelles, composed of Pluronic F127 and TPGS with proportion of 4:1 (FT), were prepared by thin-film hydration, and β-galactosidase (β-Gal) loaded FT mixed micelles were prepared by self-assembly. The brain-targeted capability of FT mixed micelles were evaluated both in vitro and in vivo...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585953/a-facile-strategy-for-fine-tuning-the-stability-and-drug-release-of-stimuli-responsive-cross-linked-micellar-nanoparticles-towards-precision-drug-delivery
#20
Kai Xiao, Tzu-Yin Lin, Kit S Lam, Yuanpei Li
Precision drug delivery has a great impact on the application of precision oncology for better patient care. Here we report a facile strategy for fine-tuning the stability, drug release and responsiveness of stimuli-responsive cross-linked nanoparticles towards precision drug delivery. A series of micellar nanoparticles with different levels of intramicellar disulfide crosslinkages could be conveniently produced with a mixed micelle approach. These micellar nanoparticles were all within a size range of 25-40 nm so that they could take full advantage of the enhanced permeability and retention (EPR) effect for tumor-targeted drug delivery...
June 14, 2017: Nanoscale
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