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https://www.readbyqxmd.com/read/29342326/mixed-fluorotryptophan-substitutions-at-the-same-residue-expand-the-versatility-of-%C3%A2-%C3%A2-f-protein-nmr-spectroscopy
#1
Calem Kenward, Kyungsoo Shin, Jan Rainey
The strategy of applying fluorine NMR to characterize ligand binding to a membrane protein prepared with mixtures of tryptophans substituted with F at different positions on the indole ring was tested. The ¹⁹F NMR behavior of 4-, 5-, 6-, and 7-fluorotryptophan were directly compared as a function of both micellar environment and fragment size for two overlapping apelin receptor (AR/APJ) segments - one with a single transmembrane (TM) helix and two tryptophan residues, the other with three TM helices and two additional tryptophan residues...
January 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29335186/rheological-and-calorimetric-study-of-alkyltrimethylammonium-bromide-sodium-salicylate-wormlike-micelles-in-aqueous-binary-systems
#2
Karl Jan Clinckspoor, Laila Lorenzetti Jorge, Heinz Hoffmann, Edvaldo Sabadini
HYPOTHESIS: It is known that additives like glycerol and sucrose lead to the swelling of aqueous bilayer Lα phases. The swelling of the Lα phases can be explained by the increase of the refractive index of the mixed solvent, which lowers the van der Waals attraction between the bilayers. Afterwards, the undulation forces between the bilayers can push them apart. This hypothesis was previously extended to wormlike micelles (WLM) of cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal)...
January 6, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331472/influence-of-partially-demineralized-milk-proteins-on-rheological-properties-and-microstructure-of-acid-gels
#3
G H Meletharayil, H A Patel, L E Metzger, C Marella, T Huppertz
Innovative clean label processes employed in the manufacture of acid gels are targeted to modify the structure of proteins that contribute to rheological properties. In the present study, CO2-treated milk protein concentrate powder with 80% protein in dry matter (TMPC80) was mixed with nonfat dry milk (NDM) in different ratios for the manufacture of acid gels. Dispersions of NDM and TMPC80 that provided 100, 90, 70, and 40% of protein from NDM were reconstituted to 4.0% (wt/wt) protein and 12.0% (wt/wt) total solids...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29328617/sinter-resistant-and-highly-active-sub-5-nm-bimetallic-au-cu-nanoparticle-catalyst-encapsulated-in-silica-for-high-temperature-carbon-monoxide-oxidation
#4
Navid Zanganeh, Vamshi Krishna Guda, Hossein Toghiani, Jason M Keith
A novel gold-copper based silica encapsulated mixed metal oxide (MMO) core-shell catalyst - with sub 5-nm MMO particles - was successfully synthesized via a reverse micelle process. The SiO2 encapsulated MMO catalyst was reduced under hydrogen flow to produce Au-Cu@SiO2 catalyst. XRD and XPS characterization confirmed the presence of Au-Cu nanocomposites in the catalyst while TEM characterization revealed the core-shell structure of the catalyst with the presence of sub 5-nm Au-Cu nanoparticle cores inside SiO2 shells...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327653/preparation-and-in-vitro-and-in-vivo-evaluation-of-quercetin-loaded-mixed-micelles-for-oral-delivery
#5
Zhen Lu, Cuiping Bu, Weicheng Hu, Hui Zhang, Mengrui Liu, Meiqi Lu, Guangxi Zhai
Quercetin (QT) is a plant polyphenol with various pharmacological properties. However, the low water solubility limits its therapeutic efficacy. In the present study, QT-loaded sodium taurocholate-Pluronic P123 (QT-loaded ST/P123) mixed micelles were developed and characterized, and the effect of the formulation on improving the water solubility of QT was investigated. QT-loaded ST/P123 mixed micelles were prepared by thin film hydration-direct dissolution and optimized by uniform design. The optimal formulation possessed high drug loading (12...
January 12, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29325213/a-new-colorimetric-platform-for-protein-detection-based-on-recognition-induced-cascade-of-polymeric-nanoparticles-disassembly
#6
Fang Fang, Jin Liu, Yushu Li, Junjiao Yang, Jing Yang
Despite great progress, it is still of high interest to explore new homogeneous assays for simple, visual, and selective protein detection. Herein, one new colorimetric sensor has been developed for visual detection of protein by using polymeric micelles as a sensing scaffold and the molecular recognition between protein and the ligand on the surface of the polymeric micelles as the driving force to trigger the readout of the detection signal. The polymeric micelles formed via the self-assembly of the amphiphilic block polymer biotin-labeled poly(ethylene glycol)-block-poly(3-acryl aminophenylboronic acid) are endowed with colorful feature by incorporation of alizarin red S (ARS) into the hydrophobic core...
January 11, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29313693/poloxamer-407-tpgs-mixed-micelles-as-promising-carriers-for-cyclosporine-ocular-delivery
#7
Maria Aurora Grimaudo, Silvia Pescina, Cristina Padula, Patrizia Santi, Angel Concheiro, Carmen Alvarez-Lorenzo, Sara Nicoli
Cyclosporine is an immunosuppressant agent approved for the treatment of dry eye disease and used off-label for other ocular pathologies. Its formulation and ocular bioavailability is a real challenge due to the large molecular weight (1.2 kDa), high lipophilicity and low water solubility. The aim of the work was to develop an aqueous micellar formulation for an efficient cyclosporine delivery to the ocular tissues, using a water soluble derivative of vitamin E (TPGS: d-alpha tocopheryl polyethylene glycol 1000 succinate) and a poloxamer (poloxamer 407) as excipients...
January 9, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29313392/improved-intestinal-absorption-of-paclitaxel-by-mixed-micelles-self-assembled-from-vitamin-e-succinate-based-amphiphilic-polymers-and-their-transcellular-transport-mechanism-and-intracellular-trafficking-routes
#8
Xiaoyou Qu, Yang Zou, Chuyu He, Yuanhang Zhou, Yao Jin, Yunqiang Deng, Ziqi Wang, Xinru Li, Yanxia Zhou, Yan Liu
To ensure that antitumor drugs can be effectively transported across intestinal barrier and then quickly released in tumor cells, mixed polymeric micelles (Mix-PMs) were designed and fabricated by combining poly(2-ethyl-2-oxazoline)-vitamin E succinate (PEOz-VES) with TPGS1000 for enhancing intestinal absorption of paclitaxel. PEOz-VES exhibited an extremely low critical micelle concentration and negligible cytotoxicity. The Mix-PMs were characterized to have about 20 nm in diameter, uniform spherical morphology, high drug-loading content and sustained drug release profile with a retained pH-sensitivity...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29291554/switching-worm-based-viscoelastic-fluid-by-ph-and-redox
#9
Yongmin Zhang, Fei Qin, Xuefeng Liu, Yun Fang
HYPOTHESIS: The smart responsive behavior of wormlike micelles (WLMs) depends on a special group in the monomer. Surfactant bearing selenium atom and the carboxylic acid group is expected to be redox- and pH- responsive. Hence, the redox- or pH- induced transition in molecular structure should allow a tuning of the morphology of the aggregates, thereby affecting macroscopic viscoelasticity. EXPERIMENTS: A viscoelastic fluid based on WLMs was fabricated by mixing potassium benzylselanylundecyl carboxylate (BSeUK), and commercially available sulfobetaine surfactant (C16DSB) with a stoichiometric ratio of 1:1 in a guanidine hydrochloride solution...
December 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29289823/toltrazuril-mixed-nanomicelle-delivery-system-based-on-sodium-deoxycholate-brij-c20-polyethylene-ether-triton-x100-characterization-solubility-and-bioavailability-study
#10
Li Zhang, Dandan Ren, Jianyu Zhou, Guangneng Peng, Gang Shu, Zhixiang Yuan, Fei Shi, Ling Zhao, Lizi Yin, Guoqing Fan, Chang Liu, Hualin Fu
Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals. However, the drug has poor aqueous solubility (25 °C, 0.41 μg/mL), and its dose escalation for systemic administration remains challenging. We engineered a Tol mixed nanomicelle (TMNM) delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100 (NaDC-Brij58-Tx100) as surfactants by film hydration method. The physical properties of TMNM were characterized, and the pharmacokinetic parameters of Tol and TMNM were compared...
December 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29288741/optimization-of-washing-conditions-with-biogenic-mobilizing-agents-for-marine-fuel-contaminated-beach-sands
#11
Alessia Arelli, Andrea Nuzzo, Claudia Sabia, Ibrahim M Banat, Giulio Zanaroli, Fabio Fava
Washing is a rapid and effective treatment to remediate contaminated sands impacted by oil spills, although synthetic additives used to increase extraction efficiency may cause additional pollution issues due to their intrinsic toxicity and very often low biodegradability. In this study, different biogenic mobilizing agents (soybean lecithins, cyclodextrins, cholic acids, plant-derived cleaners, rhamnolipids and sophorolipids) were tested in the washing of beach sands artificially contaminated with the Intermediate Fuel Oil IFO-180...
December 27, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29285934/synthetic-polymeric-mixed-micelles-target-to-lymph-node-triggering-enhanced-cellular-and-humoral-immune-responses
#12
Chenxi Li, Xiaoxu Zhang, Qing Chen, Jiulong Zhang, Wenpan Li, Haiyang Hu, Xiuli Zhao, Mingxi Qiao, Dawei Chen
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines since antigen presentation and initiation of T cell-mediated immune responses occur primarily at these locations. In this study, amphiphilic diblock copolymer PEOz-PLA combined with carboxylterminalted-Pluronic F127 were used to construct mixed micelles (carboxylated-NPs) for co-delivery of antigen OVA and Toll-like receptor-7 agonist CL264 (carboxylated-NPs/OVA/CL264) to the LN resident DCs. The results showed that the small, sub-60nm size of the self-assembled mixed micelles enables them to rapidly penetrate into lymphatic vessels and reach DLNs after subcutaneous injection...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29285083/quercetin-loaded-mixed-micelles-exhibit-enhanced-cytotoxic-efficacy-in-non-small-cell-lung-cancer-in-vitro
#13
Ming-Hong Zhao, Lin Yuan, Ling-Yun Meng, Jian-Ling Qiu, Chun-Bin Wang
In the present study, quercetin (QUR)-loaded mixed micelles (QUR-M) were prepared with the aim of improving the physicochemical and anticancer efficacy of QUR in lung cancer cells. The mixed micelles comprised tocopheryl polyethylene glycol 1000 succinate (TPGS) and a 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine derivative of polyethylene glycol. The nanosized QUR-M exhibited a pH-responsive and controlled release of QUR that is likely to be beneficial in cancer treatment. The results of an MTT assay clearly demonstrated that the anticancer effect of QUR-M in A549 cancer cells was stronger compared with that of free QUR at 24 and 48 h time points...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29275642/enhancement-of-dissolution-and-oral-bioavailability-of-lacidipine-via-pluronic-p123-f127-mixed-polymeric-micelles-formulation-optimization-using-central-composite-design-and-in-vivo-bioavailability-study
#14
Ahmed R Fares, Aliaa N ElMeshad, Mohamed A A Kassem
This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation variables to obtain LCDP polymeric micelles of high entrapment efficiency and small and uniform particle size (PS). Formulation variables were: Pluronic to drug ratio (A) and Pluronic P123 percentage (B). LCDP polymeric micelles were assessed for entrapment efficiency (EE%), PS and polydispersity index (PDI)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29261298/how-to-tune-the-gene-delivery-and-biocompatibility-of-poly-2-4-aminobutyl-2-oxazoline-by-self-and-co-assembly
#15
Meike N Leiske, Fabian H Sobotta, Stephanie Hoeppener, Johannes C Brendel, Anja Traeger, Ulrich S Schubert
Despite their promising potential in gene transfection, the toxicity and limited efficiency of cationic polymers as non-viral vectors are major obstacles for their broader application. The large amount of cationic charges, e.g. in poly(ethylene imine) (PEI) is known to be advantageous in terms of their transfection efficiency, but goes hand-in-hand with a high toxicity. Consequently, an efficient shielding of the charges is required to minimize toxic effects. In this study, we use a simple mixed micelle approach to optimize the required charge density for efficient DNA complex formation and to minimize toxicity by using a biocompatible polymer...
December 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29241981/uptake-of-iron-iii-ethylenediamine-n-n-n-n-tetraacetic-acid-complex-by-phosphatidylcholine-lipid-film-part-ii-effect-of-film-curvature
#16
Masumi Villeneuve, Mihoko Tanaka, Natsumi Saito, Hiroyasu Sakamoto, Yoshiteru Hayami
Mixed micelles formed in a ternary-solute aqueous solution of NaOH, iron (III)-ethylenediamine-N,N,N',N'-tetraacetic acid complex (Fe-edta) and 1,2-diheptanoyl-sn-glycero-3-phosphatidyl choline (DHPC) were studied and compared with the mixed adsorbed film reported in Part I of this series to clarify the effect of the curvature of molecular assemblies on the interactions between their Fe-edta and DHPC constituents. The critical micelle concentrations (CMCs), surface tension at the CMC, and solution pH were measured as functions of the mole fractions of NaOH and DHPC...
December 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29238023/study-of-cationic-and-nonionic-mixed-micelles-with-nabr-and-3-5-cl2c6h3co2na-by-use-of-probe-nucleophilic-reaction-of-piperidine-with-ionized-phenyl-salicylate
#17
Ibrahim Isah Fagge, Khalisanni Khalid, Muhammad Azri Mohd Noh, Nor Saadah Muhammad Yusof, Sharifuddin Md Zain, Mohammad Niyaz Khan
Behaviors of cationic and nonionic mixed micelles in the form of hexadecyltrimethylammonium bromide (HDABr) and hexadecyltrimethylammonium bromide-Polyethylene glycol hexadecyl ether (C16E20), in the presence of inert salts (NaBr and 3,5-dichlorosodium benzoate), by the use of reaction probe between Pp and ionized PhSH (Pp = piperidine and PhSH = phenyl salicylate), has been reported in this work. The values of RXBr (RXBr denotes ion exchange constants obtained in the presence of micelles of different structural features) or KXBr (KXBr denotes ion exchange constants obtained in the presence of micelles of the same structural features) for 3,5-Cl2C6H3CO2- were almost the same at three different [HDABr]T (0...
December 14, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29235901/a-novel-mixed-polymeric-micelle-for-co-delivery-of-paclitaxel-and-retinoic-acid-and-overcoming-multidrug-resistance-synthesis-characterization-cytotoxicity-and-pharmacokinetic-evaluation
#18
Jaber Emami, Mahboubeh Rezazadeh, Mahboubeh Mashayekhi, Mahboubeh Rostami, Ali Jahanian-Najafabadi
In the current study, retinoic acid (RA) was conjugated to Pluronic F127 (PF127) through an esterification process. Mixed micelles were formed with tocopheryl polyethylene glycol 1000 (TPGS) for co-delivery of paclitaxel (PTX) and RA to the cancer cells. Mixed micelles of RA-PF127 and TPGS in different weight ratios (10:0, 7:3, 5:5, 3:7, 0:10 w/w) were prepared and physicochemical properties including, particle size, zeta potential, critical micelle concentration (CMC), drug loading content, entrapment efficiency, drug release, cellular uptake and in vitro cytotoxicity, were investigated in details...
December 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29227489/synergism-and-aggregation-behaviour-in-an-aqueous-binary-mixture-of-cationic-zwitterionic-surfactants-physico-chemical-characterization-with-molecular-simulation-approach
#19
Bharatkumar Kanoje, Shailesh Padshala, Jigisha Parikh, Suban K Sahoo, Ketan Kuperkar, Pratap Bahadur
Aqueous interactions between a cationic surfactant benzyl dimethylhexadecylammonium chloride (BDHAC) and alkyldimethylammoniopropane sulfonates (CnDAPS) based three zwitterionic surfactants n = 10, 12, and 14 (abbreviated as C10DAPS, C12DAPS and C14DAPS, respectively) were studied using tensiometry, and fluorescence spectrophotometry techniques. The critical micelle concentration degree of synergism and various other parameters such as interaction parameter (β), activity coefficients (fm) and interfacial parameters such as surface pressure (πCMC), packing parameter (P), surface excess concentration (Γmax), surface tension at CMC (γCMC), and minimum area per molecule (Amin) were evaluated using the Regular Solution Theory (RST) of mixed systems...
December 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29205039/comparison-of-two-static-in-vitro-digestion-methods-for-screening-bioaccessibility-of-carotenoids-in-fruits-vegetables-and-animal-products
#20
Daniele Bobrowski Rodrigues, Chureeporn Chitchumroonchokchai, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante, Mark L Failla
In vitro digestion methods are routinely used to assess the bioaccessibility of carotenoids and other dietary lipophilic compounds. Here, we compared the recovery of carotenoids and their efficiency of micellarization in digested fruits, vegetables, egg yolk, salmon and mixed vegetable salad with and without the animal products using the static INFOGEST method (Maniekus et al. Food Funct. 2014, 5, 1113-1124) and the procedure of Failla et al. (Food Funct. 2014, 5, 1101-1112) modified to simulate conditions for the fed state...
December 5, 2017: Journal of Agricultural and Food Chemistry
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