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mixed micelles

Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng, Yongxing Zhao
OBJECTIVE: Rheumatoid arthritis (RA) is associated with chronic inflammation. The suppression of inflammation is key to the treatment of RA. Glucocorticoids (GCs) are classical anti-inflammatory drugs with several disadvantages such as poor water solubility and low specificity in the body. These disadvantages are the reasons for the quick elimination and side effects of GCs in vivo. Micelles are ideal carriers for GCs delivery to inflamed synovium. We set out to improve the targeting and pharmacokinetic profiles of GCs by preparing a targeting micelle system...
November 2018: Drug Delivery
Yu-Ying Chien, Tung-Yun Wang, Po-Wen Liao, Wen-Chung Wu, Ching-Yi Chen
A folic acid targeted mixed micelle system based on co-assembly of poly(ε-caprolactone)-b-poly(methoxytri(ethylene glycol) methacrylate-co-N-(2-methacrylamido)ethyl folatic amide) and poly(ε-caprolactone)-b-poly(diethylene glycol monomethyl ether methacrylate) is developed to encapsulate indocyanine green (ICG) for photothermal therapy and photodynamic therapy. In this study, the use of folic acid is not only for specific cancer cell recognition, but also in virtue of the carboxylic acid on folic acid to regulate the pH-dependent thermal phase transition of polymeric micelles for controlled drug release...
May 7, 2018: Macromolecular Bioscience
Chengzhi Zhu, Rongyi Yao, Yanjun Chen, Mengran Feng, Shuai Ma, Chaocan Zhang
HYPOTHESIS: The microfluidic technology can drive molecules to organize into aggregates with nano-structures, and gives a possibility to control aggregate morphologies by adjusting hydrodynamic parameters of microfluidics. COMSOL Multiphysics is a useful software to simulate the mixing situation of solutions in microfluidic. Here, experiments and simulation are combined to study the self-assembly of gradient copolymers in the microfluidic device. EXPERIMENTS: Fluorinated gradient copolymers self-assembled in a three-dimensional co-flow focusing microfluidic device (3D CFMD)...
April 18, 2018: Journal of Colloid and Interface Science
Haibo Tan, Jing Tang, Joel Henzie, Yunqi Li, Xingtao Xu, Tao Chen, Zhongli Wang, Jiayu Wang, Yusuke Ide, Yoshio Bando, Yusuke Yamauchi
Triblock copolymer micelles coated with melamine-formaldehyde resin were self-assembled into closely-packed two-dimensional arrangements on the surface of graphene oxide sheets. Carbonizing these structures created a two-dimensional architecture composed of reduced graphene oxide (rGO) sandwiched between two monolayers composed of sub-40-nm diameter hollow nitrogen-doped carbon nanospheres (N-HCNS). Electrochemical tests showed that these hybrid structures had better performance for the oxygen reduction compared to physically mixed rGO and N-HCNS that were not chemically bonded together...
May 3, 2018: ACS Nano
Yingying Ding, Changyuan Wang, Yutong Wang, Youwei Xu, Jing Zhao, Meng Gao, Yanfang Ding, Jinyong Peng, Lei Li
BACKGROUND: Although piperine can inhibit cells of tumors, the poor water solubility restricted its clinical application. This paper aimed to develop mixed micelles based on Soluplus® and TPGS, to improve the aqueous solubility and anti-cancer effect. METHODS: Piperine -loaded mixed micelles were prepared using a thin- film hydration method, and their physicochemical properties were characterized. The cellular uptake of the micelles was confirmed by confocal laser scanning microscopy in A549 lung cancer cells and HepG2 liver cancer cells...
May 2, 2018: Drug Development and Industrial Pharmacy
Akash Gulyani, Nilanjan Dey, Santanu Bhattacharya
An amphiphilic pyrene-terpyridine (Pytpy) probe forms novel, fluorescent nanoaggregates in phospholipid membranes. This unique membrane-driven self-assembly of Pytpy shows large Stokes shifts and long-lived fluorescent states and efficiently reports on vesicle-micelle transition through ratiometric changes. Strikingly, Pytpy can even distinguish between bilayer-like domains and more-dynamic micelle-like 'rim' phases that co-exist in mixed assemblies (bicelles).
May 2, 2018: Chemical Communications: Chem Comm
Filip Dusa, Wen Chen, Joanna Witos, Susanne Kristina Wiedmer
Nanoplasmonic sensing (NPS), based on localized surface plasmon resonance, with sensors composed of glass covered with golden nanodisks and overlaid with a SiO2 coating was applied in this study. Egg phosphatidylcholine (eggPC), being an easily accessible membrane-forming lipid, was used for preparation of biomimicking membranes. Small unilamellar vesicles with an approximate hydrodynamic diameter of 30 nm, formed by sonication in HEPES buffer, were adsorbed within 10 min on the sensor surface either as intact vesicles or as a planar bilayer...
May 1, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Suprava Maharana, Pramila Kumari Misra
The interactions, nature of the organization, and physicochemical properties of alkyltrimethylammonium bromides (Cn¬TAB , n=12, 14, and 16)-gelatin mixed assemblies were investigated by UV-visible spectrometry, surface tensiometry, and fluorimetry techniques. The synergistic interaction between the surfactant and gelatin was established from the decrease in critical micellar concentration (CMC) and increase in molecular parking area of surfactants with increase in percentage of gelatin from 0 to 0.4%; e.g...
April 26, 2018: Journal of Physical Chemistry. B
Manik Mandal, George Farid, Michal Kruk
Bridged-organosilica nanotubes with a variety of bridging groups (methylene, ethylene, ethenylene, phenylene and p-xylylene) were synthesized using swollen mixtures of Pluronic triblock copolymer surfactants as micellar templates. The mixtures consisted of Pluronic F127 surfactant (EO106 PO70 EO106 ) with long poly(ethylene oxide), PEO, blocks, which help prevent the formation of consolidated structures, and another Pluronic with shorter PEO blocks and higher poly(propylene oxide) content, which promote swelling and the cylindrical micelle morphology...
April 4, 2018: Journal of Colloid and Interface Science
Aijing Lu, Zhengzhong Wu, Xianglin Luo, Suming Li
Micelles of poly(ε-caprolactone)-b-poly(N,N-diethylaminoethyl methacrylate)/(N-(3-sulfopropyl-N-methacryloxyethy-N,N-diethylammonium betaine)) (PCL-PDEAPS) and poly(ε-caprolactone)-b-poly(ethylene glycol) (PCL-PEG) were prepared and characterized. The interactions of micelles with model proteins such as bovine serum albumin (BSA), lysozyme (Ly), fibrinogen (Fg) and plasma were studied from adsorption quantity, micelle size, polydispersity index (PDI) and zeta-potential measurements. The adsorption quantity of negatively charged proteins on PCL-PDEAPS micelles containing zwitterionic sulfobetaine is larger than on non-ionic PEG-PCL micelles...
April 9, 2018: Colloids and Surfaces. B, Biointerfaces
Zhai Zhaolan, Yan Xinyan, Ji Xu, Song Zhanqian, Shang Shibin, Xiaoping Rao
The phase behaviors and aggregates in a catanionic system have been investigated. The anionic surfactants in the mixed systems are sodium N-alkyl-maleimidepimaric carboxylate (Cn-MPA-Na, n=12, 14, 16), which are prepared from rosin and contain a large rigid skeleton and a flexible alkane chain. And the cationic surfactant is cetyltrimethylammonium bromide (CTAB). The phase behavior of C14-MPA-Na/CTAB system transforms form a viscoelastic solution to an aqueous surfactant two-phase system (ASTP), an aqueous surfactant three-phase system (AS3P) and an anisotropic homogeneous phase in sequence when C14-MPA-Na concentration continuously increases from 10 to 35 mM...
April 19, 2018: Chemistry: a European Journal
Marielle Margier, Caroline Buffière, Pascale Goupy, Didier Remond, Charlotte Halimi, Catherine Caris, Patrick Borel, Emmanuelle Reboul
SCOPE: Food matrix is generally believed to alter carotenoid bioavailability, but its effect on xanthophylls is usually limited. We thus aimed to decipher the digestion-absorption process of lutein in the presence or not of a food matrix. METHODS: We assessed lutein transfer to gastric-like lipid droplets or artificial mixed micelles when lutein was added to test meals either as a pure molecule ((all-E)-lutein) or in canned spinach ((Z) + (all-E)-lutein). The obtained mixed micelles were delivered to Caco-2 cells to evaluate lutein uptake...
April 17, 2018: Molecular Nutrition & Food Research
Maisa Vuorte, Jukka Määttä, Maria Sammalkorpi
Here, we study one component and mixed n-alkyl-poly(ethylene oxide) (Cm En ) micelles with varying poly(ethylene oxide) (PEG) chain lengths n using coarse-grained molecular simulations. These non-ionic alkyl-PEG surfactants and their aggregates are widely used in bio and chemical technology. As expected, the simulations show that increasing the PEG chain length decreases the alkyl-PEG micelle core diameter and aggregation number but also enhances PEG chain penetration to the core region and spreads the micelle corona...
April 17, 2018: Journal of Physical Chemistry. B
Samira Jafarzadeh-Holagh, Sameereh Hashemi-Najafabadi, Hossein Shaki, Ebrahim Vasheghani-Farahani
Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy. Among the vast number of different nanocarrier systems applied to deliver chemotherapeutics to cancer tumor, intelligent systems which deliver drug to various sites in the body have attracted considerable attentions. Finding a specific stimulant that triggers the carrier to release its payload in the target tissue is a key parameter for efficacy of delivery systems. Acidic pH of cancer tumor helps a pH-sensitive carrier to release drug at the tumor site...
March 1, 2018: Journal of Colloid and Interface Science
Lan Tang, Lulu Fu, Zhuanfeng Zhu, Yan Yang, Boxuan Sun, Weiguang Shan, Zhenhai Zhang
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine. Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailability of Cucurbitacin B (CuB). The physicochemical property of micelles was characterized, which confirmed the successful modification of the nanomicelles. CPs-modified nanomicelles in vitro were found to significantly increase cellular uptake and transportation...
January 1, 2018: Drug Delivery
Mozhgan Mohammadzadeh, Masoud Honarvar, Ali Reza Zarei, Masoud Mashhadi Akbar Boojar, Hossein Bakhoda
The aim of this work was to explore the possibility of the application of cloud point extraction (CPE) method in micelle media to recovery betaine from beet molasses. Response surface method was employed to assess the effects of surfactant concentration, molasses concentration, incubation time, pH, electrolyte concentration, mixing time, and surfactant type on efficiency of betaine recovery from beet molasses. Also, a mathematical model was developed to predict the effect of each variable and their interactions on the efficiency of betaine recovery...
April 2018: Journal of Food Science and Technology
Qi Diao, Xiaoyang Li, Mengxiao Diao, Yong-Ill Lee, Hong-Guo Liu
HYPOTHESIS: Our previous studies have shown that the metal nanoparticle/polymer composite structures fabricated at the liquid/liquid interface have good reusability but lower catalytic activity for heterogeneous reactions in aqueous solutions. This should be attributed to the poor water wettability and more compact structure of the polymer matrices. Therefore, it should be possible to improve the catalytic activity through designing and fabricating a porous composite structure with good water wettability...
March 22, 2018: Journal of Colloid and Interface Science
Timothy Gruenhagen, Joshua J Ziarek, Jonathan P Schlebach
The conformational equilibria of integral membrane proteins have proven extremely difficult to characterize within native lipid bilayers. To circumvent technical issues, investigations of the structure and stability of α- helical membrane proteins are often carried out in mixed micelle or bicelle solvents that mimic the membrane and facilitate measurements of reversible folding. Under these conditions, the energetics of membrane protein folding are typically proportional to the mole fraction of an anionic detergent in the micelle...
March 31, 2018: Protein Science: a Publication of the Protein Society
Emmanuel Odella, Ruben Dario Falcone, Marcelo Ceolin, Juana J Silber, N Mariano Correa
The most critical problem regarding the use of reverse micelles (RMs) in several fields is the toxicity of their partial components. In this sense, many efforts have been made to characterize non-toxic RMs formulations based on biological amphiphiles and/or different oils. In this contribution, the microstructure of biocompatible mixed RMs formulated by sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT) and tri-n-octylphosphine oxide (TOPO) surfactants dispersed in the friendly solvent methyl laurate was studied by using SAXS, 31P NMR and, following the solvatochromic behavior of the molecular probe 4-aminophthalimide (4-AP)...
March 28, 2018: Journal of Physical Chemistry. B
Ying Du, Wei Yan, Hua Lian, Chenyang Xiang, Lijie Duan, Chunsheng Xiao
In this work, a new kind of polyion complex (PIC) micelles with pH and reduction dual responsiveness was developed for effective intracellular drug delivery. The PIC micelles can be readily prepared by mixing a polycationic block polymer, methoxy poly(ethylene glycol)-b-poly(l-lysine) (mPEG-PLL), with a small molecule polyacid, 2, 2'-dithiodisuccinic acid (DTS) in aqueous media. The resultant PIC micelles are of uniform spherical shapes with hydrodynamic radii ranging from 65 to 75 nm based on different feeding ratios of mPEG-PLL and DTS...
March 15, 2018: Journal of Colloid and Interface Science
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