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https://www.readbyqxmd.com/read/28628836/an-affinity-based-aqueous-two-phase-mixed-micellar-system-and-its-purification-of-yeast-3-5-bisphosphate-nucleotidase
#1
Yao Liu, Mei-Hao Sun, Shi-Kuan Shao, Gang Deng
Aqueous two-phase micellar system (ATPMS), as an alternative liquid-liquid extraction technique, has been extensively exploited for the precise separation or large-scale concentration of biomolecules. In this article, a novel affinity-based ATPMS composed of mixed micelles was constructed by introducing a Copper-chelated Triton X-114 (TX-Cu(II)) into an aqueous solution of hydrophobically modified ethylene oxide polymer (HM-EO). Phase diagram of the HM-EO/TX-Cu(II) system was measured, and the partitioning behavior of model proteins (YND, BSA, lysozyme) were studied by using this new system...
May 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28628835/low-frequency-sonic-waves-assisted-cloud-point-extraction-of-polyhydroxyalkanoate-from-cupriavidus-necator
#2
Sivananth Murugesan, Regupathi Iyyaswami
Low frequency sonic waves, less than 10kHz were introduced to assist cloud point extraction of polyhydroxyalkanoate from Cupriavidus necator present within the crude broth. Process parameters including surfactant system variables and sonication parameters were studied for their effect on extraction efficiency. Introduction of low frequency sonic waves assists in the dissolution of microbial cell wall by the surfactant micelles and release of cellular content, polyhydroxyalkanoate granules released were encapsulated by the micelle core which was confirmed by crotonic acid assay...
June 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28627869/the-effects-of-detergent-micelles-on-lipid-binding-to-proteins-in-electrospray-ionization-mass-spectrometry
#3
Michael Landreh, Joana Costeira-Paulo, Joseph Gault, Erik G Marklund, Carol V Robinson
A wide variety of biological processes rely upon interactions between proteins and lipids, ranging from molecular transport to the organization of the cell membrane. It was recently established that electrospray ionization mass spectrometry (ESI-MS) is capable of capturing transient interactions between membrane proteins and their lipid environment, and a detailed understanding of the underlying processes is therefore of high importance. Here, we apply ESI-MS to investigate the factors that govern complex formation in solution and gas phases by comparing non-selective lipid binding with soluble and membrane proteins...
June 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28627562/a-novel-combined-chemical-kinetic-and-trapping-method-for-probing-the-relationships-between-chemical-reactivity-and-interfacial-h2o-br-and-h-ion-molarities-in-ctab-c12e6-mixed-micelles
#4
Aijaz Ahmad Dar, Laurence S Romsted, Nighat Nazir, Yongliang Zhang, Xiang Gao, Qing Gu, Changyao Liu
A delicate balance-of-forces governs the interactions responsible for surfactant self-assembly and chemical reactivity within them. Chemical reactions in micellar media generally occur in the interfacial region of micelles that is a complex mixture of: water, headgroups, counterions, co-ions, acids or bases, organic solvents, and the reactants themselves. We have carried out a detailed study of a complex chemical reaction in mixed CTAB/C12E6 micelles by using the chemical kinetic (CK) and chemical trapping (CT) methods...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28603959/characterization-of-complex-polymer-self-assemblies-and-large-aggregates-by-multi-detector-thermal-field-flow-fractionation
#5
Upenyu Lucky Muza, Guilaume Greyling, Harald Pasch
Micelles prepared from amphiphilic block copolymers (ABCs) have found numerous applications in pharmaceutical, electronic, environmental, cosmetic and hygiene industries. These micelles, whether in the pure or mixed micelle form, often exist as multiple morphologies (spherical, cy-lindrical, worm or vesicular) in equilibrium with each other. None of the current column-based fractionation techniques or any microscopic technique are capable of a successful separation, identification and quantitation of these complex self-assemblies with regards to morphology, size, molar mass and chemical composition in one experiment...
June 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28594018/biodegradable-injectable-polymer-systems-exhibiting-a-longer-and-controllable-duration-time-of-the-gel-state
#6
Yasuyuki Yoshida, Hiroki Takai, Keisuke Kawahara, Shintaro Mitsumune, Kazuyuki Takata, Akinori Kuzuya, Yuichi Ohya
Here, we report biodegradable temperature-triggered covalent gelation systems exhibiting a longer and controllable duration time of the gel state by a "mixing strategy" utilizing a thiol-ene reaction. We synthesized a tri-block copolymer of poly(caprolactone-co-glycolic acid) and PEG (tri-PCG) as a temperature-responsive injectable polymer (IP) and attached acryloyl groups on both termini (tri-PCG-Acryl). A tri-PCG micelle solution containing hydrophobic hexa-functional polythiol (Solution-A) and a tri-PCG-Acryl micelle solution (Solution-B) were mixed together...
June 8, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28592843/pluronic-f127-and-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-tpgs-mixed-micelles-for-targeting-drug-delivery-across-the-blood-brain-barrier
#7
Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB). Rhodamine 123 (Rho123) and DiR loaded mixed micelles, composed of Pluronic F127 and TPGS with proportion of 4:1 (FT), were prepared by thin-film hydration, and β-galactosidase (β-Gal) loaded FT mixed micelles were prepared by self-assembly. The brain-targeted capability of FT mixed micelles were evaluated both in vitro and in vivo...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28585953/a-facile-strategy-for-fine-tuning-the-stability-and-drug-release-of-stimuli-responsive-cross-linked-micellar-nanoparticles-towards-precision-drug-delivery
#8
Kai Xiao, Tzu-Yin Lin, Kit S Lam, Yuanpei Li
Precision drug delivery has a great impact on the application of precision oncology for better patient care. Here we report a facile strategy for fine-tuning the stability, drug release and responsiveness of stimuli-responsive cross-linked nanoparticles towards precision drug delivery. A series of micellar nanoparticles with different levels of intramicellar disulfide crosslinkages could be conveniently produced with a mixed micelle approach. These micellar nanoparticles were all within a size range of 25-40 nm so that they could take full advantage of the enhanced permeability and retention (EPR) effect for tumor-targeted drug delivery...
June 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28579543/exenatide-loaded-microsphere-thermosensitive-hydrogel-long-acting-delivery-system-with-high-drug-bioactivity
#9
Puxiu Wang, Xuezhi Zhuo, Wei Chu, Xing Tang
A series of mixed hydrogels of PLGA-PEG-PLGA and PCLA-PEG-PCLA were synthesized, and investigated in terms of their critical micelle concentration, stability and thermosensitive properties. Also, some mixed hydrogel was selected to prepare Depot-gel-in-Ms-in-Matrix-gel system for the treatment of type 2 diabetes mellitus. Briefly, Exenatide (EXT) loaded hydrogels was encapsulated in PLGA microspheres (Ms) and further encapsulated into blank hydrogel. The mechanism of Exenatide release involved drug diffusion, hydrogel diffusion, PLGA erosion and mixed hydrogel erosion...
June 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28572926/evidence-for-decreased-interaction-and-improved-carotenoid-bioavailability-by-sequential-delivery-of-a-supplement
#10
Dawna Salter-Venzon, Valentina Kazlova, Samantha Izzy Ford, Janjira Intra, Allison E Klosner, Kevin W Gellenbeck
Despite the notable health benefits of carotenoids for human health, the majority of human diets worldwide are repeatedly shown to be inadequate in intake of carotenoid-rich fruits and vegetables, according to current health recommendations. To address this deficit, strategies designed to increase dietary intakes and subsequent plasma levels of carotenoids are warranted. When mixed carotenoids are delivered into the intestinal tract simultaneously, competition occurs for micelle formation and absorption, affecting carotenoid bioavailability...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28552723/enhanced-effect-of-folated-pluronic-f87-pla-tpgs-mixed-micelles-on-targeted-delivery-of-paclitaxel
#11
Xiang Yuan Xiong, Xiaoqian Pan, Long Tao, Feng Cheng, Zi Ling Li, Yan Chun Gong, Yu Ping Li
Targeted drug delivery systems have great potential to overcome the side effect and improve the bioavailability of conventional anticancer drugs. In order to further improve the antitumor efficacy of paclitaxel (PTX) loaded in folated Pluronic F87/poly(lactic acid) (FA-F87-PLA) micelles, D-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS or Vitamin E TPGS) were added into FA-F87-PLA to form FA-F87-PLA/TPGS mixed micelles. The LE of PTX-loaded mixed micelles (13.5%) was highest in the mass ratio 5 to 3 of FA-F87-PLA to TPGS...
May 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28541037/phase-behavior-of-salt-free-polyelectrolyte-gel-surfactant-systems
#12
Martin Andersson, Per Hansson
Ionic surfactants tend to collapse the outer parts of polyelectrolyte gels, forming shells that can be used to encapsulate other species including protein and peptide drugs. In this paper, the aqueous phase behavior of covalently cross-linked polyacrylate networks containing sodium ions and dodecyltrimethylammonium ions as counterions is investigated by means of swelling isotherms, dye staining, small-angle X-ray scattering, and confocal Raman spectroscopy. The equilibrium state is approached by letting the networks absorb pure water...
June 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28529382/reversibly-manipulating-the-surface-chemistry-of-polymeric-nanostructures-via-a-grafting-to-approach-mediated-by-nucleobase-interactions
#13
Zan Hua, Robert Keogh, Zhen Li, Thomas R Wilks, Guosong Chen, Rachel K O'Reilly
"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new "grafting to" approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM)...
May 9, 2017: Macromolecules
https://www.readbyqxmd.com/read/28527375/surfactant-enhanced-remediation-of-polycyclic-aromatic-hydrocarbons-a-review
#14
REVIEW
Shanti Lamichhane, K C Bal Krishna, Ranjan Sarukkalige
Polycyclic aromatic hydrocarbons (PAHs) are toxic, mutagenic and carcinogenic organic compounds that are widely present in the environment. The bioremediation of PAHs is an economical and environmentally friendly remediation technique, but it is limited because PAHs have low water solubility and fewer bioavailable properties. The solubility and bioavailability of PAHs can be increased by using surfactants to reduce surface tension and interfacial tension; this method is called surfactant-enhanced remediation (SER)...
September 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28514015/preparation-of-mesoporous-basic-mixed-metal-oxides-through-assembly-of-monodispersed-mg-al-layered-double-hydroxide-nanoparticles
#15
Yuya Oka, Yoshiyuki Kuroda, Takamichi Matsuno, Keigo Kamata, Hiroaki Wada, Atsushi Shimojima, Kazuyuki Kuroda
Mesoporous basic Mg-Al mixed metal oxides (MMOs) with a high surface area and large pore size were prepared through the assembly of monodispersed layered double hydroxide nanoparticles (LDHNPs) with block copolymer templates. The particle sizes of the LDHNPs were controlled mainly by varying the concentration of tris(hydroxymethyl)aminomethane (THAM), which was used as a surface stabilizing agent for the LDHNPs. LDHNPs and micelles of a block copolymer (Pluronic F127) were assembled to form a composite. The composites were calcined to transform them into mesoporous MMOs and remove the templates...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28504251/programmable-co-delivery-of-the-immune-checkpoint-inhibitor-nlg919-and-chemotherapeutic-doxorubicin-via-a-redox-responsive-immunostimulatory-polymeric-prodrug-carrier
#16
Jing-Jing Sun, Yi-Chao Chen, Yi-Xian Huang, Wen-Chen Zhao, Yan-Hua Liu, Raman Venkataramanan, Bin-Feng Lu, Song Li
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 prodrug polymers were self-assembled into nano-sized micelles that served as a carrier to load DOX (DOX/PSSN10 micelles)...
June 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28501705/doxorubicin-delivered-by-a-redox-responsive-dasatinib-containing-polymeric-prodrug-carrier-for-combination-therapy
#17
Jingjing Sun, Yanhua Liu, Yichao Chen, Wenchen Zhao, Qianyu Zhai, Sanjay Rathod, Yixian Huang, Suoqin Tang, Yong Tae Kwon, Christian Fernandez, Raman Venkataramanan, Song Li
Two novel prodrug polymers POEG-b-PSSDas (redox-sensitive) and POEG-b-PCCDas (redox-insensitive), which consist of poly(oligo(ethylene glycol) methacrylate) (POEG) hydrophilic blocks and dasatinib (DAS, an oncogenic tyrosine kinases inhibitor) conjugated hydrophobic blocks, were designed as dual-functional carriers for codelivery with doxorubicin (DOX). Both carriers retained antitumor activity of DAS and could form mixed micelles with DOX. Compared to POEG-b-PCCDas micelles, incorporation of disulfide linkage into POEG-b-PSSDas micelles facilitated efficient cleavage of DAS from prodrug micelles in tumor cells/tissues, leading to a higher level of anti-tumor activity in vitro and in vivo...
May 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28494698/extemporaneously-preparative-biodegradable-injectable-polymer-systems-exhibiting-temperature-responsive-irreversible-gelation
#18
Yasuyuki Yoshida, Kazuyuki Takata, Hiroki Takai, Keisuke Kawahara, Akinori Kuzuya, Yuichi Ohya
On clinical application of biodegradable injectable polymer (IP) systems, quick extemporaneous preparation of IP formulations and longer duration time gel state after injection into the body are the important targets to be developed. Previously, we had reported temperature-responsive covalent gelation systems via bio-orthogonal thiol-ene reaction by 'mixing strategy' of amphiphilic biodegradable tri-block copolymer (tri-PCG) attaching acryloyl groups on both termini (tri-PCG-Acryl) with reactive polythiol. In other previous works, we found 'freeze-dry with PEG/dispersion' method as quick extemporaneous preparation method of biodegradable IP formulations...
May 23, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28494589/complexes-covered-with-phosphorylcholine-groups-prepared-by-mixing-anionic-diblock-copolymers-and-cationic-surfactants
#19
Keita Nakai, Kazuhiko Ishihara, Shin-Ichi Yusa
Anionic diblock copolymers (PmAn) composed of biocompatible polybetaine, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), and anionic poly(sodium 2-(acrylamido)-2-methylpropanesulfonate) (PAMPS) were synthesized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. Two types of diblock copolymers (P24A217 and P100A99) were prepared with different compositions. The PmAn/CTAB complexes were formed by a stoichiometrically charge-neutralized mixture of anionic PmAn and cationic cetyltrimethylammonium bromide (CTAB) micelles in water...
May 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28485939/creating-quasi-two-dimensional-cluster-assembled-materials-through-self-assembly-of-a-janus-polyoxometalate-silsesquioxane-co-cluster
#20
Han Wu, Yu-Qi Zhang, Min-Biao Hu, Li-Jun Ren, Yue Lin, Wei Wang
Clusters are an important class of nanoscale molecules or superatoms that exhibit an amazing diversity in structure, chemical composition, shape, and functionality. Assembling two types of clusters is creating emerging cluster-assembled materials (CAMs). In this paper, we report an effective approach to produce quasi two-dimensional (2D) CAMs of two types of spherelike clusters, polyhedral oligomeric silsesquioxanes (POSS), and polyoxometalates (POM). To avoid macrophase separation between the two clusters, they are covalently linked to form a POM-POSS cocluster with Janus characteristics and a dumbbell shape...
May 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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