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https://www.readbyqxmd.com/read/29156122/preparation-of-lignin-sds-composite-nanoparticles-and-its-application-in-pickering-emulsion-template-based-microencapsulation
#1
Yuxia Pang, Shengwen Wang, Xueqing Qiu, Yanling Luo, Hongming Lou, Jinhao Huang
Lignin is a vastly underutilized biomass resource. The preparation of water dispersed lignin nanoparticles is an effective way to realize the high-value utilization of lignin. However, the currently reported preparation methods of lignin nanoparticles still have some drawbacks, such as the requirement for toxic organic solvent or chemical modification, complicated operation process and poor dispersibility. Here, lignin/SDS composite nanoparticles (LSNPs) with outstanding water dispersibility and a size range of 70-200 nm were facilely prepared via acidifying the mixed basic solution of alkaline lignin and sodium dodecyl sulfate (SDS)...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29155597/aggregation-and-rheological-behavior-of-the-lavender-oil-pluronic-p123-microemulsions-in-water-ethanol-mixed-solvents
#2
Oyais Ahmad Chat, Nighat Nazir, Parvaiz Ahmad Bhat, Puthusserickal Abdulrahiman Hassan, Vinod Kumar Aswal, Aijaz Ahmad Dar
The effect of lavender oil on aggregation characteristics of P123 in aqueous-ethanolic solutions is investigated systematically by DLS, SANS and Rheology. The solubilization capacity of the formulation increased by increasing P123 concentration. The study unveiled the importance of the short chain alcohol-ethanol, as solubilization enhancer. The apparent hydrodynamic radius (Rh) increased significantly with increase in lavender oil concentration up to maximum oil solubilization capacity of the copolymer at a particular ethanol concentration...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29154096/sorption-and-desorption-of-17%C3%AE-ethinylestradiol-onto-sediments-affected-by-rhamnolipidic-biosurfactants
#3
Yan-Ping Guo, Yong-You Hu, Hui Lin, Xue-Lian Ou
Many studies have addressed the desorption and mobilization performances of sorbed contaminants affected by different rhamnolipidic biosurfactants. Study results have been mixed and complicated. Rhamnolipids are always microbial produced with variable homologues. In this study, two representative rhamnolipidic fractions (i.e., RL-F1 and RL-F2, which are mono- and di-rhamnolipids, respectively) were investigated and compared to determine their influence on 17α-ethynylestradiol (EE2) distribution within sediment-water sorption and desorption systems...
November 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29150015/the-flotation-and-adsorption-of-mixed-collectors-on-oxide-and-silicate-minerals
#4
REVIEW
Longhua Xu, Jia Tian, Houqin Wu, Zhongyuan Lu, Wei Sun, Yuehua Hu
The analysis of flotation and adsorption of mixed collectors on oxide and silicate minerals is of great importance for both industrial applications and theoretical research. Over the past years, significant progress has been achieved in understanding the adsorption of single collectors in micelles as well as at interfaces. By contrast, the self-assembly of mixed collectors at liquid/air and solid/liquid interfaces remains a developing area as a result of the complexity of the mixed systems involved and the limited availability of suitable analytical techniques...
November 11, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29147525/multi-component-hybrid-hydrogels-understanding-the-extent-of-orthogonal-assembly-and-its-impact-on-controlled-release
#5
Vânia M P Vieira, Laura L Hay, David K Smith
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved by simply mixing carefully-chosen constituents. Specifically, the individual components are: (i) pH-activated low-molecular-weight gelator (LMWG) 1,3;2,4-dibenzylidenesorbitol-4',4''-dicarboxylic acid (DBS-COOH), (ii) thermally-activated polymer gelator (PG) agarose, (iii) anionic biopolymer heparin, and (iv) cationic self-assembled multivalent (SAMul) micelles capable of binding heparin...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29138104/novel-mixed-vesicles-containing-lactobacilli-biosurfactant-for-vaginal-delivery-of-an-anti-candida-agent
#6
Angela Abruzzo, Barbara Giordani, Carola Parolin, Beatrice Vitali, Michele Protti, Laura Mercolini, Martina Cappelletti, Stefano Fedi, Federica Bigucci, Teresa Cerchiara, Barbara Luppi
The purpose of this work was to prepare and characterize an innovative formulation for vaginal delivery of econazole nitrate, commonly used for the treatment of Candida infections. A novel biosurfactant isolated from a vaginal Lactobacillus strain was used to prepare phosphatidylcholine based mixed vesicles. Biosurfactant was produced by Lactobacillus gasseri BC9, isolated from the vagina of a healthy premenopausal woman, and was chemically characterized by FT-IR and ESI-MS. Mixed vesicles, obtained through film rehydration and extrusion method, were characterized in terms of size, zeta potential, encapsulation efficiency, mucoadhesion properties and econazole release...
November 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29137992/ir-spectroscopy-analysis-of-pancreatic-lipase-related-protein-2-interaction-with-phospholipids-3-monitoring-dppc-lipolysis-in-mixed-micelles
#7
Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge A Rodriguez, Frédéric Carrière
Usual methods for the continuous assay of lipolytic enzyme activities are mainly based on the titration of free fatty acids, surface pressure monitoring or spectrophotometry using substrates labeled with specific probes. These approaches only give a partial information on the chemistry of the lipolysis reaction and additional end-point analyses are often required to quantify both residual substrate and lipolysis products. We used transmission infrared (IR) spectroscopy to monitor simultaneously the hydrolysis of phospholipids by guinea pig pancreatic lipase-related protein 2 (GPLRP2) and the release of lipolysis products...
November 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29136371/designing-dendron-polymer-conjugate-based-targeted-drug-delivery-platforms-with-a-mix-and-match-modularity
#8
Burcu Sumer Bolu, Bianka Golba, Nazli Boke, Amitav Sanyal, Rana Sanyal
Polymeric micellar systems are emerging as a very important class of nano-pharmaceuticals due to their ability to improve pharmacokinetics and bio-distribution of chemotherapy drugs, as well as to reduce related systemic toxicities. While these nano sized delivery systems inherently benefit from passive targeting through the enhanced permeation and retention effect leading to increased accumulation in the tumor, additional active targeting can be achieved through surface modification of micelles with targeting groups specific for over-expressed receptors of tumor cells...
November 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29132246/phage-derived-protein-mediated-targeted-chemotherapy-of-pancreatic-cancer
#9
Tao Wang, Radhika Narayanaswamy, Huilan Ren, James W Gillespie, Valery A Petrenko, Vladimir P Torchilin
Pancreatic cancer has been a life-threatening illness associated with high incidence and mortality rates. Paclitaxel that causes mitotic arrest in cancer cells disrupting microtubule function is used for pancreatic cancer treatment[1]. Nausea, anorexia and abdominal pain are some of the typical dose-limiting toxicity associated gastrointestinal side effects of the drug[2]. Here we present the use of polymeric mixed micelles to enable a targeted delivery of Paclitaxel and to provide additional advantages such as enhanced drug solubility, bioavailability and minimal dose-limiting toxicity...
November 13, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29131941/a-molecular-level-understanding-of-template-effects-in-ionic-liquids
#10
Roman Elfgen, Oldamur Hollóczki, Barbara Kirchner
The structure-directing or template effect has been invoked several times for ionic liquids to explain the different outcome in material synthesis, namely, different scaffolds or geometrical arrangements with varying ionic liquids. It is obvious to assume that such an effect can originate from the most likely complex microstructure, being present within the ionic liquid itself. In that regard, ionic liquids have already been shown to undergo a nanosegregation into polar and nonpolar phases, which is commonly known and denoted as microheterogeneity...
November 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29127937/reduction-sensitive-mixed-micelles-assembled-from-amphiphilic-prodrugs-for-self-codelivery-of-dox-and-dtx-with-synergistic-cancer-therapy
#11
Jilian Wu, Huiyuan Zhang, Xu Hu, Ruiling Liu, Wei Jiang, Zhonghao Li, Yuxia Luan
Clinically, codelivery of chemotherapeutics has been limited by poor water-solubility and severe systemic toxicity. In this work, we developed a new reduction-sensitive mixed micellar system for self-codelivery of doxorubicin (DOX) and docetaxel (DTX). Biodegradable methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) was coupled with DOX and DTX by a reduction-sensitive disulfide bond, resulting in mPEG-PCL-SS-DOX and mPEG-PCL-SS-DTX, respectively. mPEG-PCL-SS-DOX was mixed with mPEG-PCL-SS-DTX at a mole ratio of 1:1 in water, forming a mixed micellar system...
November 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29127906/exploring-the-intermolecular-interactions-acting-in-solvent-modified-mekc-by-molecular-dynamics-and-nmr-the-effect-of-n-butanol-on-the-separation-of-diclofenac-and-its-impurities
#12
Claudia Caprini, Benedetta Pasquini, Fabrizio Melani, Massimo Del Bubba, Alessandro Giuffrida, Enrica Calleri, Serena Orlandini, Sandra Furlanetto
An integrated approach involving CE experiments, Molecular Dynamics (MD) simulations and two-dimensional NOE spectroscopy (2D-NOESY) experiments was employed to elucidate the intermolecular interactions and the separation mechanisms involved in a solvent-modified MEKC method for the simultaneous determination of diclofenac sodium and its impurities. The CE findings indicated that the addition of n-butanol (nBuOH) to the SDS micellar solution played a primary role for controlling the partitioning into the mixed micelles and the migration of the analytes and that the presence of nBuOH as cosurfactant was compulsory for achieving the complete separation of the compounds...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29117188/potential-of-golden-potatoes-to-improve-vitamin-a-and-vitamin-e-status-in-developing-countries
#13
Chureeporn Chitchumroonchokchai, Gianfranco Diretto, Bruno Parisi, Giovanni Giuliano, Mark L Failla
Potato (Solanum tuberosum L.) is the third most widely consumed plant food by humans. Its tubers are rich in starch and vitamin C, but have low or null levels of essential nutrients such as provitamin A and vitamin E. Transformation of potato with a bacterial mini-pathway for β-carotene in a tuber-specific manner results in a "golden" potato (GP) tuber phenotype resulting from accumulation of provitamin A carotenoids (α- and β-carotene) and xanthophylls. Here, we investigated the bioaccessibility of carotenoids and vitamin E as α-tocopherol (αTC) in boiled wild type and golden tubers using in vitro digestion...
2017: PloS One
https://www.readbyqxmd.com/read/29113042/ph-responsive-micelle-based-cytoplasmic-delivery-system-for-induction-of-cellular-immunity
#14
Eiji Yuba, Naoki Sakaguchi, Yuhei Kanda, Maiko Miyazaki, Kazunori Koiwai
(1) Background: Cytoplasmic delivery of antigens is crucial for the induction of cellular immunity, which is an important immune response for the treatment of cancer and infectious diseases. To date, fusogenic protein-incorporated liposomes and pH-responsive polymer-modified liposomes have been used to achieve cytoplasmic delivery of antigen via membrane rupture or fusion with endosomes. However, a more versatile cytoplasmic delivery system is desired for practical use. For this study, we developed pH-responsive micelles composed of dilauroyl phosphatidylcholine (DLPC) and deoxycholic acid and investigated their cytoplasmic delivery performance and immunity-inducing capability...
November 4, 2017: Vaccines
https://www.readbyqxmd.com/read/29111558/the-development-of-phytosterol-lecithin-mixed-micelles-and-organogels
#15
Andrew B Matheson, Georgios Dalkas, Andrei Gromov, Stephen R Euston, Paul S Clegg
We demonstrate that by mixing the phytosterol-ester oryzanol with lecithin in an organic solvent, both components may be dispersed at much higher concentrations than they may be individually. Dynamic light scattering and molecular dynamics simulations show that the mechanism for this is the formation of r ∼ 4 nm mixed micelles. Infrared spectroscopy and simulations suggest that these micelles are formed due in part to hydrogen bonding of the phosphate of the lecithin head-group, and the phenol group of the oryzanol...
November 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29107604/the-effect-of-membrane-softeners-on-rigidity-of-lipid-vesicle-bilayers-derivation-from-vesicle-size-changes
#16
Mustafa Elsayed, Marwa M Ibrahim, Gregor Cevc
Deformability is not just a fundamentally interesting vesicle characteristic; it is also the key determinant of vesicle ability to cross the skin barrier; i.e. skin penetrability. Development of bilayer vesicles for drug and vaccine delivery across the skin should hence involve optimization of this property, which is controllable by the concentration of bilayer softeners in or near the vesicle bilayers. To this end, we propose a simple method for quantifying the effect of bilayer softeners on deformability of bilayer vesicles...
October 28, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29100946/the-interaction-of-phospholipase-a2-with-oxidized-phospholipids-at-the-lipid-water-surface-with-different-structural-organization
#17
N M Litvinko, L A Skorostetskaya, D O Gerlovsky
Phospholipase A2 (PLA2 IB) activity towards UV-irradiated (λ=180-400nm) phospholipids in comparison to non-irradiated ones was investigated using phosphatidylcholine (PC) liposomes and mixed micelles of phosphatidylcholine and sodium deoxycholate as a membrane model. PLA2 activity, determined by spectral changes of hemoglobin (Hb) under the interaction with fatty acids (product of the phospholipolysis), correlated well with the phospholipid peroxidation degree. The present work is the first study that determines the degree of oxidation of non-fragmented OxPCs, on the base of PLA2 activity...
October 31, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#18
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29096103/tuning-the-position-of-head-groups-by-surfactant-design-in-mixed-micelles-of-cationic-and-carbohydrate-surfactants
#19
Saikat Das, Edward Davis Oldham, Hans-Joachim Lehmler, Barbara L Knutson, Stephen E Rankin
HYPOTHESIS: Emerging applications of carbohydrate/cationic surfactant mixtures require not only synergistic mixing, but also accessible sugar headgroups at the exterior of micelles. A previous study showed that the glucoside headgroups of octyl-β-d-glucopyranoside aggregate at the interior of mixed micelles with equimolar cetyltrimethylammonium bromide rather than mixing with trimethylammonium groups at the corona. The current study tests the hypothesis that structural characteristics of the surfactants (the relative lengths of the alkyl tails and the type of linker) can be tuned to shift the carbohydrate groups to micelle surfaces...
October 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29089761/targeted-delivery-of-ginsenoside-compound-k-using-tpgs-peg-pcl-mixed-micelles-for-effective-treatment-of-lung-cancer
#20
Lei Yang, Zhenghai Zhang, Jian Hou, Xin Jin, Zhongcheng Ke, Dan Liu, Mei Du, Xiaobing Jia, Huixia Lv
Ginsenoside compound K (CK) is one of the effective ingredients in antitumor composition of ginsenoside. However, the poor water solubility and significant efflux have limited the widespread clinical use of CK. In this study, preparation of novel CK-loaded d-alpha-tocopheryl polyethylene glycol 1,000 succinate/poly(ethylene glycol)-poly(ε-caprolactone) mixed micelles (CK-M) is discussed to solve the above problems. Particle size, zeta potential, and morphology were characterized using dynamic light scattering and transmission electron microscopy...
2017: International Journal of Nanomedicine
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