keyword
MENU ▼
Read by QxMD icon Read
search

nanoemulsion

keyword
https://www.readbyqxmd.com/read/28094959/noninvasive-targeted-transcranial-neuromodulation-via-focused-ultrasound-gated-drug-release-from-nanoemulsions
#1
Raag D Airan, Randall A Meyer, Nicholas P K Ellens, Kelly Rhodes, Keyvan Farahani, Martin G Pomper, Shilpa D Kadam, Jordan J Green
Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, we have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug - in this case the small molecule anesthetic propofol - upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28094898/polyelectrolyte-oil-core-nanocarriers-for-localized-and-sustained-delivery-of-daunorubicin-to-colon-carcinoma-mc38-cells-the-case-of-polysaccharide-multilayer-film-in-relation-to-peg-ylated-shell
#2
Urszula Bazylińska, Jadwiga Pietkiewicz, Joanna Rossowska, Grzegorz Chodaczek, Andrzej Gamian, Kazimiera A Wilk
The authors examine properties of daunorubicin (DNR)-loaded oil-core multilayer nanocapsules prepared via layer-by-layer approach with different polyelectrolyte (PE) coatings such as a standard one (containing polysodium 4-styrenesulphonate/poly(diallyldimethyl-ammonium) chloride) and a polysaccharide-based shell (dextran/chitosan), in regard to the outer layer of poly-l-glutamic acid (PGA) grafted with polyethylene glycol (PGA-g-PEG). The nanocarriers are obtained on a cationic nanoemulsion template (stabilized by dicephalic-type surfactant, N,N-bis[3,30-(trimethylammonio)propyl]-dodecanamide dimethylsulfate) and layered with the PE shell of different thicknesses resulting in average size of 150 nm in diameter (as shown by dynamic light scattering, scanning electron microscopy and cryogenic-transmission electron microscopy, and atomic force microscopy)...
January 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28094392/3d-printing-of-self-assembling-thermoresponsive-nanoemulsions-into-hierarchical-mesostructured-hydrogels
#3
Lilian C Hsiao, Abu Zayed Md Badruddoza, Li-Chiun Cheng, Patrick S Doyle
Spinodal decomposition and phase transitions have emerged as viable methods to generate a variety of bicontinuous materials. Here, we show that when arrested phase separation is coupled to the time scales involved in three-dimensional (3D) printing processes, hydrogels with multiple length scales spanning nanometers to millimeters can be printed with high fidelity. We use an oil-in-water nanoemulsion-based ink with rheological and photoreactive properties that satisfy the requirements of stereolithographic 3D printing...
January 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/28088105/tectona-grandis-leaf-extract-free-and-associated-with-nanoemulsions-as-a-possible-photosensitizer-of-mouse-melanoma-b16-cell
#4
Cydia de Menezes Furtado, Fernando Sergio Escocio Drumond Viana de Faria, Ricardo Bentes Azevedo, Karen Py-Daniel, Ana Lygia Dos Santos Camara, Jaqueline Rodriguez da Silva, Everton de Holanda Oliveira, Anselmo Fortunato Ruiz Rodriguez, Igor Anatolievich Degterev
Over the past six years we have been studying extracts from tropical, specially Amazon, plants, to search for new sensitizers for photodynamic therapy of cancer and infectious diseases. Tectona grandis is a genus of tropical hardwood trees in the mint family, Lamiaceae. That is native to south and southeast Asia, but since the end of the 20th century is also gaining ground in the Amazon. The present work aims to evaluate the photodynamic potential of hydro-alcoholic extract from Tectona grandis LF leaves (TGE) and the same extract prepared as the oil-water nanoemulsion (TGE-NE) against melanoma B16 F10 cells...
January 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28087316/self-nanoemulsifying-lyophilized-tablets-snelts-for-flash-oral-transmucosal-delivery-of-vitamin-k-development-and-clinical-evaluation
#5
Khalid M El-Say, Tarek A Ahmed, Osama A A Ahmed, Khaled M Hosny, Fathy I Abd-Allah
Owing to limited solubility, vitamin K undergoes low bioavailability with large inter-individual variability after oral administration. This work aimed to prepare self-nanoemulsifying lyophilized tablets (SNELTs) for the flash oral transmucosal delivery of vitamin K. Twenty-one formulae of vitamin K self-nanoemulsifying drug delivery systems (SNEDDS) were prepared using different concentrations of vitamin K, Labrasol, and Transcutol according to mixture design. The SNEDDS was loaded on porous carriers and formulated as lyophilized tablets...
January 10, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28071802/essential-oils-against-pathogen-and-spoilage-microorganisms-of-fruit-juices-use-of-versatile-antimicrobial-delivery-systems
#6
Valentina Trinetta, Mark T Morgan, John N Coupland, Umut Yucel
Essential oils (EO) are increasingly used as natural antimicrobial compounds, however the effect of delivery system to enhance their antimicrobial activity has not been widely studied. Limonene (0 to 10 μL/mL) was added to microbial suspensions (∼10(5) CFU/mL) of selected foodborne pathogens (Listeria monocytogenes Scott A, Salmonella enterica Typhimurium, Escherichia coli and Staphylococcus aureus), and spoilage microorganisms (Lactobacillus plantarum, Saccharomyces cerevisiae, and Candida albicans). S...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28071592/development-and-evaluation-of-zinc-phthalocyanine-nanoemulsions-for-use-in-photodynamic-therapy-for-leishmania-spp
#7
Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Igor Almeida Rodrigues, Ana Lúcia Vazquez-Villa, Elisabete Pereira Dos Santos, Bruno da Costa Leal Ribeiro Guimarães, Cristal Dos Santos Cerqueira Coutinho, Alane Beatriz Vermelho, Eduardo Ricci Junior
Photodynamic therapy (PDT) combines light with photosensitizers (PS) for production of reactive oxygen species (ROS) that can kill infectious microorganisms such as bacteria, fungi and protozoa. The application of nanotechnology has enabled the advancement of PDT because many PS are insoluble in water, necessitating a nanocarrier as a physiologically acceptable carrier. Nanoemulsions are efficient nanocarriers for solubilizing liposoluble drugs, like the PS, in water. Cutaneous (CL) and mucocutaneous leishmaniasis (ML) are caused by different species of the genus Leishmania, transmitted to humans by sandfly bites...
February 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28070848/intravaginal-delivery-of-polyphenon-60-and-curcumin-nanoemulsion-gel
#8
Atinderpal Kaur, Yashaswee Saxena, Rakhi Bansal, Sonal Gupta, Amit Tyagi, Rakesh Kumar Sharma, Javed Ali, Amulya Kumar Panda, Reema Gabrani, Shweta Dang
Polyphenon 60 (P60) and curcumin (CUR) were loaded in a single nanoemulsion system and their combined antibacterial action was studied against uropathogenic Escherichia coli. To enhance availability at target organs and to inhibit enzymatic degradation in gastro intestinal tract, vaginal route of administration was explored. P60 + CUR nanoemulsion (NE) was formulated by ultra-sonication and optimized using Box-Behnken design. Optimized NE showed Z-average of 211.2 nm, polydispersity index of 0.343, and zeta potential of -32...
January 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28069223/sustained-release-formulations-of-citronella-oil-nanoemulsion-using-cavitational-techniques
#9
Naveen Agrawal, Ganesh L Maddikeri, Aniruddha B Pandit
Nanoemulsion synthesis has proven to be an effective way for transportation of immobile, insoluble bioactive compounds. Citronella Oil (lemongrass oil), a natural plant extract, can be used as a mosquito repellent and has less harmful effects compared to its available market counterpart DEET (N, N-Diethyl-meta-toluamide). Nanoemulsion of citronella oil in water was prepared using cavitation-assisted techniques while investigating the effect of system parameters like HLB (Hydrophilic Lipophilic Balance), surfactant concentration, input energy density and mode of power input on emulsion quality...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28049483/pterodon-emarginatus-oleoresin-based-nanoemulsion-as-a-promising-tool-for-culex-quinquefasciatus-diptera-culicidae-control
#10
Anna E M F M Oliveira, Jonatas L Duarte, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Taires Peniche, Edemilson C da Conceição, Leandra A R de Oliveira, Silvia M M Faustino, Alexandro C Florentino, José C T Carvalho, Caio P Fernandes
BACKGROUND: Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28033667/metformin-loaded-alginate-nanoparticles-as-an-effective-antidiabetic-agent-for-controlled-drug-release
#11
Sandeep Kumar, Gaurav Bhanjana, Ritesh Kumar Verma, Dinesh Dhingra, Neeraj Dilbaghi, Ki-Hyun Kim
OBJECTIVES: Present modalities for the diagnosis and treatment of diabetes still suffer from certain limitations such as erratic absorption, need of high dose, poor sensitivity or specificity, resistance, substantial morbidity and mortality, long-term complications, and patient-to-patient variability with lifetime treatment. METHODS: This study focused on the development of a water-in-oil-in-water metformin nanoemulsion as an effective method in diabetes treatment...
December 29, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28031010/nanoemulsion-for-improved-efficacy-of-phytotherapeutics-a-patent-perspective
#12
Jasjeet Narang, Ramandeep S Narang, Javed Ali, Sanjula Baboota, Navneet Nagpal, Simrat Kaur, Harkanwal Kaur
Phytoceuticals have been used extensively worldwide due to their reduced toxicity and therapeutic efficacy. The major drawback associated with their delivery which includes lack of sustained action and lipophilicity has been overcome by applications of scientific approach by scientists and researchers. Novel drug delivery systems aimed at enhancing bioavailability, reducing toxicity and in turn improving the patient compliance have been developed with success in recent times. Recent developments in the modern phytopharmaceutical research methods have also solved the major hurdles related to the extraction, identification of constituents in polyherbal systems, and standardisation thereby further facilitating the formulation of improved dosage forms with better efficacy of the herbal drugs...
December 28, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/28029520/ultrasonic-nanoemulsification-of-food-grade-trans-cinnamaldehyde-1-8-cineol-and-investigation-of-the-mechanism-of-antibacterial-activity
#13
Roya Moghimi, Atousa Aliahmadi, Hasan Rafati
Using ultrasonic technology, trans-cinnamaldehyde as a natural antibacterial compound was used to prepare nano size emulsions to increase its bioavailability and therefore bactericidal action. Nanoemulsions containing trans-cinnamaldehyde as an active agent and 1,8 cineol as co additive oil (Ostwald ripening inhibitor) were formulated using probe sonicator. Three different determining factors, namely time of sonication, surfactant to oil ratio and type of emulsifier (Tween 80 and Tween 20) were investigated to enhance the stability profile...
October 22, 2016: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28029115/development-of-orally-administered-%C3%AE-tocotrienol-gt3-nanoemulsion-for-radioprotection
#14
Grace A Ledet, Shukla Biswas, Vidya P Kumar, Richard A Graves, Demaurian M Mitchner, Taylor M Parker, Levon A Bostanian, Sanchita P Ghosh, Tarun K Mandal
The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural integrity of both the formulation and the compound. γ-tocotrienol was incorporated into a nanoemulsion and lyophilized with lactose. Ultra performance liquid chromatography-mass spectroscopy (UPLC-MS) was used to monitor the chemical stability of GT3 over time, the particle size and ζ potential, and scanning electron microscopy (SEM) were used to study the physical stability of the nanoemulsion...
December 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28026929/near-infrared-quantum-dot-and-89-zr-dual-labeled-nanoparticles-for-in-vivo-cerenkov-imaging
#15
Yiming Zhao, Travis M Shaffer, Sudeep Das, Carlos Pérez-Medina, Willem J M Mulder, Jan Grimm
Cerenkov luminescence (CL) is an emerging imaging modality that utilizes the light generated during the radioactive decay of many clinical used isotopes. Although it is increasingly used for background-free imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here, we propose to use quantum dots (QDs) as spectral converters that can transfer the CL UV-blue emissions to near-infrared light that is less scattered or absorbed in vivo. Experiments on tissue phantoms showed enhanced penetration depth and increased transmitted intensity for CL in the presence of near-infrared (NIR) QDs...
January 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28024281/photodynamic-therapy-mediated-by-acai-oil-euterpe-oleracea-martius-in-nanoemulsion-a-potential-treatment-for-melanoma
#16
Victoria Monge-Fuentes, Luis Alexandre Muehlmann, João Paulo Figueiró Longo, Jaqueline Rodrigues Silva, Maria Luiza Fascineli, Paulo de Souza, Fernando Faria, Igor Anatolievich Degterev, Anselmo Rodriguez, Fabiana Pirani Carneiro, Carolina Madeira Lucci, Patricia Escobar, Rivadávio Fernandes Batista Amorim, Ricardo Bentes Azevedo
Melanoma is the most aggressive and lethal form of skin cancer, responsible for >80% of deaths. Standard treatments for late-stage melanoma usually present poor results, leading to life-threatening side effects and low overall survival. Thus, it is necessary to rethink treatment strategies and design new tools for the treatment of this disease. On that ground, we hereby report the use of acai oil in nanoemulsion (NanoA) as a novel photosensitizer for photodynamic therapy (PDT) used to treat melanoma in in vitro and in vivo experimental models...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28009915/evidence-of-nose-to-brain-delivery-of-nanoemulsions-cargoes-but-not-vehicles
#17
Ejaj Ahmad, Yunhai Feng, Jianping Qi, Wufa Fan, Yuhua Ma, Haisheng He, Fei Xia, Xiaochun Dong, Weili Zhao, Yi Lu, Wei Wu
The nose-to-brain pathway has been proven to be a shortcut for direct drug delivery to the brain. However, whether and to what extent nanoparticles can be delivered through this passage is still awaiting validation with evidence. In this study, nose-to-brain transportation of nanoparticles is tracked via fluorescence bioimaging strategies using nanoemulsions (NEs) as model carriers. Identification of NEs in biological tissues is based on the on → off signal switching of a new type of environment-responsive embedded dyes, P2 and P4, and two conventional probes, DiR and coumarin-6 (C6), are embedded to represent the cargoes...
December 23, 2016: Nanoscale
https://www.readbyqxmd.com/read/28007632/new-perspectives-in-the-topical-delivery-of-optimized-amphotericin-b-loaded-nanoemulsions-using-excipients-with-innate-anti-fungal-activities-a-mechanistic-and-histopathological-investigation
#18
Afzal Hussain, Sima Singh, Thomas J Webster, Farhan Jalees Ahmad
This study aimed to develop nanoemulsions (NEs) for the topical delivery of Amphotericin B using lipids and surfactants with innate antifungal activity. NEs were formulated by a slow spontaneous titration method and characterized for particle size, polydispersity index, zeta potential, zone of inhibition (ZOI), in vitro release, enhanced ex vivo rat skin permeation-deposition, hemolysis followed by interaction with the skin using scanning electron microscopy, and histopathology. The ZOI values of the optimized NEs (ANE3) were 21...
December 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28003011/targeting-the-brain-with-nanomedicine
#19
Felix Rueda, Luis J Cruz
Herein, we review innovative nanomedicine-based approaches for treating, preventing and diagnosing neurodegenerative diseases. We focus on nanoscale systems such as polymeric nanoparticles (NPs), liposomes, micelles and other vehicles (e.g. dendrimers, nanogels, nanoemulsions and nanosuspensions) for targeted delivery of bioactive molecules to the brain. To ensure maximum selectivity for optimal therapeutic or diagnostic results, researchers must employ delivery systems that are non-toxic, biodegradable and biocompatible...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28002997/targeting-the-brain-with-nanomedicine
#20
Felix Rueda, Luis J Cruz
Herein, we review innovative nanomedicine-based approaches for treating, preventing and diagnosing neurodegenerative diseases. We focus on nanoscale systems such as polymeric nanoparticles (NPs), liposomes, micelles and other vehicles (e.g. dendrimers, nanogels, nanoemulsions and nanosuspensions) for targeted delivery of bioactive molecules to the brain. To ensure maximum selectivity for optimal therapeutic or diagnostic results, researchers must employ delivery systems that are non-toxic, biodegradable and biocompatible...
December 21, 2016: Current Pharmaceutical Design
keyword
keyword
28410
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"