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https://www.readbyqxmd.com/read/28443906/the-enhanced-anti-obesity-effect-and-reduced-gastric-mucosa-irritation-of-capsaicin-loaded-nanoemulsions
#1
Muwen Lu, Yong Cao, Chi-Tang Ho, Qingrong Huang
Capsaicin (CAP), the major active component of chili peppers, is known to have thermogenic and weight-loss potential. The aim of this study was to investigate the anti-obesity effects of capsaicin-loaded nanoemulsions (C-NE) on male Sprague Dawley (SD) rats treated with a high-fat diet (HFD). The food grade C-NE was prepared using capsaicin, medium chain triacylglycerols (MCT) (Neobee 1053), sucrose stearate S-370, Tween 80 and distilled water with an emulsion droplet size of 168 nm and a capsaicin loading of 80...
April 26, 2017: Food & Function
https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#2
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28441045/effects-of-topical-application-of-silver-sulfadiazine-cream-triple-antimicrobial-ointment-or-hyperosmolar-nanoemulsion-on-wound-healing-bacterial-load-and-exuberant-granulation-tissue-formation-in-bandaged-full-thickness-equine-skin-wounds
#3
Caroline C Gillespie Harmon, Jan F Hawkins, Jianming Li, Sean Connell, Margaret Miller, Megan Saenger, Lynetta J Freeman
OBJECTIVE To determine the effects of 3 topically applied treatments (1% silver sulfadiazine cream [SSC], triple antimicrobial ointment [TAO], and hyperosmolar nanoemulsion [HNE]) on microbial counts, exuberant granulation tissue (EGT) development, and reepithelialization of contaminated wounds at the distal aspect of the limbs of horses. ANIMALS 8 healthy adult horses. PROCEDURES A 2.5 × 2.5-cm, full-thickness, cutaneous wound was created at the dorsal aspect of each metacarpus and metatarsus (1 wound/limb/horse), covered with nonadhesive dressing, and bandaged...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28437753/p-gp-modulatory-acetyl-11-keto-%C3%AE-boswellic-acid-based-nanoemulsified-carrier-system-for-augmented-oral-chemotherapy-of-docetaxel
#4
Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra
In spite of being a very potent and promising drug against many types of cancer, docetaxel suffers the disadvantage of low solubility and poor bioavailability rendering it unsuitable for oral administration. Also, the available marketed formulation for intravenous administration has its inherent drawbacks owing to the presence of polysorbate 80. Here, we exploited the anticancer and P-gp inhibitory potential of naturally occurring frankincense oil to fabricate a stable docetaxel loaded nanoemulsified carrier system for oral delivery...
April 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28435268/biocompatible-nanoemulsions-based-on-hemp-oil-and-less-surfactants-for-oral-delivery-of-baicalein-with-enhanced-bioavailability
#5
Juntao Yin, Cuiyu Xiang, Peiqing Wang, Yuyun Yin, Yantao Hou
Baicalein (BCL) possesses high pharmacological activities but low solubility and stability in the intestinal tract. This study aimed to probe the potential of nanoemulsions (NEs) consisting of hemp oil and less surfactants in ameliorating the oral bioavailability of BCL. BCL-loaded NEs (BCL-NEs) were prepared by high-pressure homogenization technique to reduce the amount of surfactants. BCL-NEs were characterized by particle size, entrapment efficiency (EE), in vitro drug release, and morphology. Bioavailability was studied in Sprague-Dawley rats following oral administration of BCL suspensions, BCL conventional emulsions, and BCL-NEs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28433750/nanoemulsion-based-electrolyte-triggered-in-situ-gel-for-ocular-delivery-of-acetazolamide
#6
Nadia Morsi, Magdy Ibrahim, Hanan Refai, Heba El Sorogy
In the present work the antiglaucoma drug, acetazolamide, was formulated as an ion induced nanoemulsion-based in situ gel for ocular delivery aiming a sustained drug release and an improved therapeutic efficacy. Different acetazolamide loaded nanoemulsion formulations were prepared using peanut oil, tween 80 and/or cremophor EL as surfactant in addition to transcutol P or propylene glycol as cosurfactant. Based on physicochemical characterization, the nanoemulsion formulation containing mixed surfactants and transcutol P was selected to be incorporated into ion induced in situ gelling systems composed of gellan gum alone and in combination with xanthan gum, HPMC or carbopol...
April 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28428086/evaluation-of-garlic-oil-in-nano-emulsified-form-optimization-and-its-efficacy-in-high-fat-diet-induced-dyslipidemia-in-wistar-rats
#7
Gokulakannan Ragavan, Yuvashree Muralidaran, Badrinathan Sridharan, Rajesh Nachiappa Ganesh, Pragasam Viswanathan
Garlic oil nanoemulsion was formulated using ultrasonic emulsification and the optimized garlic oil nanoemulsion ratio (1:2) of oil: surfactant showed spherical, with tiny droplet size 24.9 ± 1.11 nm. It was observed that the prepared nanoemulsion has the zeta potential of -42.63 ± 1.58 mV and a low polydispersity index of 0.2 ± 0.09 with excellent stability. The formulation was subjected to in vivo acute and sub-acute toxicity. In acute toxicity study, single oral administration of 18.63 ml of garlic oil nanoemulsion/kg resulted in immediate mortality...
April 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28427660/ultrasound-processed-nanoemulsion-a-comparative-approach-between-resveratrol-and-resveratrol-cyclodextrin-inclusion-complex-to-study-its-binding-interactions-antioxidant-activity-and-uv-light-stability
#8
Raj Kumar, Khushwinder Kaur, Shivani Uppal, S K Mehta
Resveratrol is a naturally occurring therapeutic molecule used for treatment of diseases caused by oxidative stress. This investigation elucidates the advantages of fabrication of size controlled resveratrol inclusion complex. This has been done by encapsulating resveratrol-cyclodextrin inclusion complex in a phospholipid stabilized nanoemulsion formulated by ultrasonication emulsification method. The prepared nanoemulsion has been compared with resveratrol encapsulated nanoemulsion system. The morphology of the resveratrol nanoemulsion and inclusion complex nanoemulsion have been observed using transmission electron microscopy with average size 20...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427044/on-the-reverse-micelle-effect-in-liquid-scintillation-counting
#9
Youcef Nedjadi, Jean-Pascal Laedermann, François Bochud, Claude Bailat
This work looks into the tracks of electrons in nanoemulsive scintillating media using the Monte Carlo Geant4-DNA code which simulates event-by-event interactions of electrons in liquid water down to the eV, without resorting to the condensed history method. It demonstrates that the average number of micelles in which electrons deposit energy is quite large, increasing with their emission energy, decreasing with micelle size, and rising with micelle concentration. The probability of an electron ending its track in a micelle is found to be rather large and micelle size-dependent below 1keV, and approximating the aqueous fraction at higher energies...
April 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28412398/recent-update-on-nanoemulgel-as-topical-drug-delivery-system
#10
REVIEW
Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu, Prashant Kesharwani
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it...
April 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28410669/curcumin-and-linseed-oil-co-delivered-in-phospholipid-nanoemulsions-enhances-the-levels-of-docosahexaenoic-acid-in-serum-and-tissue-lipids-of-rats
#11
D Sugasini, B R Lokesh
Docosahexaenoic acid (DHA) is an important long chain omega-3 polyunsaturated fatty acid (PUFA) primarily found in marine fishes. The diets of vegetarian population do not contain preformed DHA, but they can derive it from shorter chain α-linolenic acid (ALA) found in plant oils. However, the conversion efficiency of ALA to DHA is minimal in human adults. This may cause insufficiency of DHA in the vegetarian population. Curcumin, diferuloyl methane found in the spice turmeric, has the potential to increase the formation of DHA from ALA by activating the enzymes FADS2 and elongase 2...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28405572/emerging-role-of-nanoemulsions-in-oral-health-management
#12
EDITORIAL
Jasjeet Kaur Narang, Ramandeep Singh Narang
No abstract text is available yet for this article.
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28405165/enhancement-of-physicochemical-properties-of-nanocolloidal-carrier-loaded-with-cyclosporine-for-topical-treatment-of-psoriasis-in-vitro-diffusion-and-in-vivo-hydrating-action
#13
Siti Hajar Musa, Mahiran Basri, Hamid Reza Fard Masoumi, Norashikin Shamsudin, Norazlinaliza Salim
Psoriasis is a chronic autoimmune disease that cannot be cured. It can however be controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment is the first-line treatment and favored by most physicians, as this form of therapy has more patient compliance. Introducing a nanoemulsion for transporting cyclosporine as an anti-inflammatory drug to an itchy site of skin disease would enhance the effectiveness of topical treatment for psoriasis. The addition of nutmeg and virgin coconut-oil mixture, with their unique properties, could improve cyclosporine loading and solubility...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28394635/prevention-of-fungal-spoilage-in-food-products-using-natural-compounds-a-review
#14
Susana Ribes, Ana Fuentes, Pau Talens, Jose Manuel Barat
The kingdom Fungi is the most important group of microorganism contaminating food commodities, and chemical additives are commonly used in the food industry to prevent fungal spoilage. However, the increasing consumer concern about synthetic additives has led to their substitution by natural compounds in foods. The current review provides an overview of using natural agents isolated from different sources (plants, animals and microorganisms) as promising antifungal compounds, including information about their mechanism of action and their use in foods to preserve and prolong shelf life...
April 10, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28391698/pegylated-nanoemulsions-for-oral-delivery-role-of-the-inner-core-on-the-final-fate-of-the-formulation
#15
Manuel J Santander-Ortega, Maria Plaza-Oliver, Virginia Rodriguez-Robledo, Lucia Castro-Vazquez, Noemi Villaseca-Gonzalez, Joaquin Gonzalez-Fuentes, Emilio L Cano, Pilar Marcos, Maria Victoria Lozano, Maria Mar Arroyo-Jimenez
During the last decade, there has been growing interest to grant nanoparticles with diffusion properties across mucosae. In this sense, the non-ionic block copolymer Pluronic F127 (PF127) has arisen as a promising coating agent to formulate mucus penetrating particles (MPP). In the journey to find efficient coating agents, most of the studies have been focused more on the effect of the coating agent architecture rather than on the role the physicochemical properties of the nanoparticle used as substrate...
April 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28389708/mathematical-modeling-and-experimental-validation-of-nanoemulsion-based-drug-transport-across-cellular-barriers
#16
Ekta Kadakia, Lipa Shah, Mansoor M Amiji
PURPOSE: Nanoemulsions have shown potential in delivering drug across epithelial and endothelial cell barriers, which express efflux transporters. However, their transport mechanisms are not entirely understood. Our goal was to investigate the cellular permeability of nanoemulsion-encapsulated drugs and apply mathematical modeling to elucidate transport mechanisms and sensitive nanoemulsion attributes. METHODS: Transport studies were performed in Caco-2 cells, using fish oil nanoemulsions and a model substrate, rhodamine-123...
April 7, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28385252/characterization-of-basil-seed-gum-based-edible-films-incorporated-with-zataria-multiflora-essential-oil-nanoemulsion
#17
Hadi Hashemi Gahruie, Esmaeil Ziaee, Mohammad Hadi Eskandari, Seyed Mohammad Hashem Hosseini
Direct introduction of essential oils (EOs) into biopolymer-based packaging materials faces various challenges such as insolubility and loss of activity. The aim of this study was increasing the bioactivity of Zataria multiflora essential oil (ZMEO) through first making a nanoemulsion and then immobilizing within basil seed gum (BSG)-based film network. ZMEO (nano)emulsions were prepared using high intensity ultrasound approach at 150W and various sonication times (0, 2.5, 5 and 10min). An increase in the antibacterial activity of ZMEO nanoemulsion was observed by decreasing the nanoemulsion droplet size...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28378606/efficacy-of-nano-and-microemulsion-based-topical-gels-in-delivery-of-ibuprofen-an-in-vivo-study
#18
Mosayeb Azizi, Fariba Esmaeili, Ali Reza Partoazar, Shahram Ejtemaei Mehr, Amir Amani
AIM: Nanoemulsion have shown many advantages in drug delivery systems. In this study, for the first time, analgesic and anti-inflammatory properties of a nanomelusion of almond oil with and without ibuprofen was compared with corresponding microemulsion and commercial topical gel of the drug using formalin and carrageenan tests, respectively. METHOD: Almond oil (oil phase) was mixed with Tween 80 and Span 80 (surfactants), and ethanol (co-surfactant) and them distilled water (aqueous phase) was then added to the mixture at once...
April 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28376733/efficacy-of-intravitreal-injection-of-2-methoxyestradiol-in-regression-of-neovascularization-of-a-retinopathy-of-prematurity-rat-model
#19
Azza Mohamed Ahmed Said, Rania Gamal Eldin Zaki, Rania A Salah Eldin, Maha Nasr, Samar Saad Azab, Yaser Abdelmageuid Elzankalony
BACKGROUND: Retinopathy of prematurity (ROP) is one of the targets for early detection and treatment to prevent childhood blindness in world health organization programs. The purpose of study was to evaluate the efficacy of intravitreal injection of 2-Methoxyestradiol (2-ME) nanoemulsion in regressing neovascularization of a ROP rat model. METHODS: A prospective comparative case - control animal study conducted on 56 eyes of 28 healthy new born Sprague Dawley male albino rat...
April 4, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28372245/optimization-of-olive-oil-based-o-w-nanoemulsions-prepared-through-ultrasonic-homogenization-a-response-surface-methodology-approach
#20
Tahir Mehmood, Asif Ahmad, Anwaar Ahmed, Zaheer Ahmed
The present study was conducted to prepare co-surfactant free, olive-oil based alpha tocopherol nanoemulsions, using a food grade non-ionic surfactant. Response surface methodology (RSM) was used to determine the effects of independent variables (ultrasonic homogenization time, olive oil concentrations and surfactant contents) on different physico-chemical characteristics of O/W nanoemulsions. This study was carried out using a central composite design. The coefficients of determination were greater than 0...
August 15, 2017: Food Chemistry
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