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https://www.readbyqxmd.com/read/28343120/nanoemulgel-using-a-bicephalous-heterolipid-as-a-novel-approach-to-enhance-transdermal-permeation-of-tenofovir
#1
Sanjeev Rambharose, Rahul S Kalhapure, Thirumala Govender
Improvements in permeation enhancement strategies, such as nanoemulsions (NEs) and nanoemulgels (NEGs), have led to a renewed interest in transdermal drug delivery (TDD). This study aimed to investigate the potential of LLA1E, a novel dendritic permeation enhancer, as an oily phase in the development of a NEG for the TDD of tenofovir (TNF). TNF loaded NEs (TNEs) were prepared and analysed for mean globule diameter (MGD), polydispersity index (PDI), zeta potential (ZP) and morphology. NEGs of the TNEs (TNEGs) were prepared and evaluated for ex vivo transdermal permeation efficacy...
March 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28340526/an-experimental-study-on-flow-and-heat-transfer-characteristics-of-ethanol-polyalphaolefin-nanoemulsion-flowing-through-circular-minichannels
#2
Vu Trinh, Jiajun Xu
This work experimentally studied the convective flow and heat transfer characteristics of a novel nanostructured heat transfer fluid: "ethanol/polyalphaolefin nanoemulsion" flowing through 12 circular minichannels of 1-mm diameter each. Ethanol/polyalphaolefin nanoemulsion is a thermodynamically stable system formed by dispersing ethanol into a mixture of "polyalphaolefin (PAO)" and surfactants. In this study, ethanol/PAO nanoemulsion is used as the working fluid to study the effect of ethanol nanodroplets on its convective flow and heat transfer characteristics...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28336899/nanoemulsified-d-limonene-reduces-the-heat-resistance-of-salmonella-senftenberg-over-50-times
#3
María Ros-Chumillas, Alberto Garre, Javier Maté, Alfredo Palop, Paula M Periago
Salmonella Senftenberg is a pathogen agent causative of foodborne disease and it is considered the most heat-resistant serovar within this genus. Food industries use heat treatment and chemical antimicrobials in order to eliminate this microorganism in food, but consumers prefer natural antimicrobials as essential oils and their components. This study evaluates the combined effect of thermal treatments and different concentrations of D-limonene nanoemulsion on the inactivation of Salmonella (S.) Senftenberg...
March 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28335351/modified-nanoemulsions-with-iron-oxide-for-magnetic-resonance-imaging
#4
Yongyi Fan, Rui Guo, Xiangyang Shi, Steven Allen, Zhengyi Cao, James R Baker, Su He Wang
A nanoemulsion (NE) is a surfactant-based, oil-in-water, nanoscale, high-energy emulsion with a mean droplet diameter of 400-600 nm. When mixed with antigen and applied nasally, a NE acts as a mucosal adjuvant and induces mucosal immune responses. One possible mechanism for the adjuvant effect of this material is that it augments antigen uptake and distribution to lymphoid tissues, where the immune response is generated. Biocompatible iron oxide nanoparticles have been used as a unique imaging approach to study the dynamics of cells or molecular migration...
November 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28326458/vitamin-e-rich-nanoemulsion-enhances-the-antitumor-efficacy-of-low-dose-paclitaxel-by-driving-th1-immune-response
#5
Jun Ye, Wujun Dong, Yanfang Yang, Huazhen Hao, Hengfeng Liao, Bangyuan Wang, Xue Han, Yiqun Jin, Xuejun Xia, Yuling Liu
PURPOSE: To overcome the drawbacks of high dose regimen and improve the outcomes of chemotherapy at a low dose, an immunotherapeutic nanoemulsion based combination of chemotherapeutic agent (paclitaxel) with immunomodulatory agent (vitamin E) was developed and evaluated for their antitumor effect against breast cancer. METHODS: A total of five nanoemulsions loaded with various content of vitamin E were prepared and characterized. The immunoregulatory effects of vitamin E along with the overall antitumor efficacy of vitamin E-rich nanoemulsion with a low dose of paclitaxel were investigated through in vitro and in vivo experiments...
March 21, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28322948/development-of-curcumin-loaded-chitosan-polymer-based-nanoemulsion-gel-in-vitro-ex-vivo-evaluation-and-in-vivo-wound-healing-studies
#6
Lydia Thomas, Foziyah Zakira, Mohd Aamir Mirza, Md Khalid Anwer, Farhan Jalees Ahmad, Zeenat Iqbal
In the present study, various nanoemulsions were prepared using Labrafac PG+Triacetin as oil, Tween 80 as a surfactant and polyethylene glycol (PEG 400) as a co-surfactant. The developed nanoemulsions (NE1-NE5) were evaluated for physicochemical characterizations and ex-vivo for skin permeation and deposition studies. The highest skin deposition was observed for NE2 with 46.07% deposition amongst all developed nanoemulsions (NE1-NE5). Optimized nanoemulsion (NE2) had vesicle size of 84.032±0.023nm, viscosity 78...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28319384/eugenol-nanoemulsion-stabilized-with-zein-and-sodium-caseinate-by-self-assembly
#7
Lei Wang, Yue Zhang
Eugenol-loaded nanoemulsion by zein and sodium caseinate (NaCas) was prepared without using specific equipment or organic solvents. The deprotonated eugenol in hot alkaline was added into NaCas/zein mixtures with different mass ratios at pH 11.5, and then neutralized to pH 7.0. The nanoemulsions showed well-defined diameter (around 109-139 nm) and negative surface potential (-28.5~ -35.8 mv). The entrapment efficiency (EE) of 1% v/v eugenol reached 84.24% by 2% m/v NaCas/zein at a mass ratio of 1:1. This formulation also showed the narrowest size distribution, extraordinary stability during ambient storage (22 oC) up to 30 days, and retained good re-dispersiblity after spray- or freeze- drying...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28314255/anti-metastatic-efficacy-of-traditional-chinese-medicine-tcm-ginsenoside-conjugated-to-a-vefgr-3-antibody-on-human-gastric-cancer-in-an-orthotopic-mouse-model
#8
Xiaojun Dai, Dongmei Liu, Moxiang Liu, Xiaochun Zhang, Weiming Wang, Feng Jin, Yayun Qian, Xuanyi Wang, Jingjing Zhao, Yongjian Wu, Fangfang Xiong, N A Chang, Y U Sun, Zhijian Yang, Robert M Hoffman, Yanqing Liu
Background/Aim: The aim of the present study was to investigate the efficacy of a traditional Chinese medicine (TCM), VEGFR-3 antibody-conjugated ginsenoside Rg3nanoemulsion (VRIN), targeting lymphangiogenesis, on the inhibition of tumor growth and metastasis in an orthotopic mouse model of human gastric cancer. Materials and Methods: An orthotopic nude-mouse model of gastric cancer was established with the red fluorescent protein (RFP)-expressing human gastric cancer cell line NUGC-4-RFP. The tumor-bearing mice were treated with vehicle (0...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28306222/functionalizing-nanoemulsions-with-carboxylates-impact-on-the-biodistribution-and-pharmacokinetics-in-mice
#9
Mohamed F Attia, Sidy M Dieng, Mayeul Collot, Andrey S Klymchenko, Caroline Bouillot, Christophe A Serra, Marc Schmutz, Meriem Er-Rafik, Thierry F Vandamme, Nicolas Anton
Efficiency of drug administration is related to the inhibition of adverse effects, and can be improved by drug targeting through lipid nanocarriers encapsulation. Targeting technology generally goes along with the nanocarrier functionalization that can be surface modification and/or ligand grafting. The great advantage of nanoemulsions is their loading capability and the possibilities to encapsulate several entities in a single droplet, however, the decoration of the lipid droplets with strongly anchored reactive functions is challenging...
March 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28302419/intravenous-15-isoflurane-lipid-nanoemulsion-for-general-anesthesia-in-dogs
#10
Claudio C Natalini, Carolina L Krahn, Priscila B S Serpa, Joanna E Griffith, Ricardo Miyasaka de Almeida
OBJECTIVE: To investigate the efficacy of a new intravenous (IV) nanoemulsified isoflurane formulation for maintenance of general anesthesia in dogs. STUDY DESIGN: Prospective, crossover, experimental study. ANIMALS: Seven healthy, mature, mixed-breed dogs, three male and four female, weighing 11.5 ± 1.5 kg. METHODS: Anesthesia was induced with propofol for instrumentation. Measurements were obtained before administration of either inhaled isoflurane (Iso-I) or IV 15% isoflurane-loaded lipid nanoemulsion (Iso-nano)...
January 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28293282/modeling-and-optimization-of-nanoemulsion-containing-sorafenib-for-cancer-treatment-by-response-surface-methodology
#11
Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim, Kamyar Shameli
The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy emulsification method and optimized by response surface methodology. The effects of overhead stirring time, high shear rate, high shear time, and cycles of high-pressure homogenizer were studied in the preparation of nanoemulsion loaded with Sorafenib. Most of the particles in nanoemulsion are spherical in shape, the smallest particle size being 82...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28284120/evaluation-of-toxic-cytotoxic-and-genotoxic-effects-of-phytol-and-its-nanoemulsion
#12
Muhammad Torequl Islam, Leticia Streck, Marcus Vinícius Oliveira Barros de Alencar, Samara Wanessa Cardoso Silva, Kátia da Conceição Machado, Keylla da Conceição Machado, Antonio Luiz Gomes Júnior, Márcia Fernanda Correia Jardim Paz, Ana Maria Oliveira Ferreira da Mata, João Marcelo de Castro E Sousa, Joaquim Soares da Costa Junior, Hercília Maria Lins Rolim, Arnobio Antonio da Silva-Junior, Ana Amélia de Carvalho Melo-Cavalcante
Phytol (PYT) is a diterpenoid having important biological activity. However, it is a water non-soluble compound. This study aims to prepare PYT nanoemulsion (PNE) and evaluation of toxic, cytotoxic and genotoxic activities of PYT and PNE. For this, the PNE was prepared by the phase inversion method. The cytotoxicity test was performed in Artemia salina, while toxicity, cytotoxicity and genotoxicity in Allium cepa at concentrations of 2, 4, 8 and 16 mM. Potassium dichromate and copper sulfate were used as positive controls for the tests of A...
March 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28279798/nanoemulsion-concepts-development-and-applications-in-drug-delivery
#13
REVIEW
Yuvraj Singh, Jaya Gopal Meher, Kavit Raval, Farooq Ali Khan, Mohini Chaurasia, Nitin K Jain, Manish K Chourasia
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as ultrafine dispersions whose differential drug loading; viscoelastic as well as visual properties can cater to a wide range of functionalities including drug delivery. However there is still relatively narrow insight regarding development, manufacturing, fabrication and manipulation of nanoemulsions which primarily stems from the fact that conventional aspects of emulsion formation and stabilization only partially apply to nanoemulsions...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28274503/protective-effect-of-an-astaxanthin-nanoemulsion-against-neomycin-induced-hair-cell-damage-in-zebrafish
#14
Yosuke Takemoto, Yoshinobu Hirose, Kazuma Sugahara, Makoto Hashimoto, Hirotaka Hara, Hiroshi Yamashita
No abstract text is available yet for this article.
March 5, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28267668/transport-of-lipid-nano-droplets-through-mdck-epithelial-cell-monolayer
#15
Pulkit Khatri, Jun Shao
This study aims to investigate the transport of lipid nano-droplets through MDCK epithelial cell monolayer. Nanoemulsions of self-nano-emulsifying drug delivery systems (SNEDDS) labeled with radioactive C18 triglyceride were developed. The effect of droplet size and lipid composition on the transport was investigated. The results showed that the lipid nano-droplet transport through MDCK cell monolayer was as high as 2.5%. The transport of lipid nano-droplets was higher for nanoemulsions of medium chain glycerides than the long chain glycerides...
February 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28266352/preparation-of-carotenoid-extracts-and-nanoemulsions-from-lycium-barbarum-l-and-their-effects-on-growth-of-ht-29-colon-cancer-cells
#16
H J Hsu, R F Huang, T H Kao, B S Inbaraj, B H Chen
Lycium barbarum L., a traditional Chinese herb widely used in Asian countries, has been demonstrated to be protective against chronic diseases such as age-related macular degeneration. The objectives of this study were to determine the carotenoid content in L. barbarum by high-performance liquid chromatography-mass spectrometry, followed by preparation of a carotenoid nanoemulsion to evaluate the mechanism of inhibition on HT-29 colon cancer cells. The highest extraction yield of carotenoids was attained by employing a solvent system of hexane-ethanol-acetone (1:1:1, v/v/v)...
March 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28259803/nanoemulsion-loaded-gel-for-topical-co-delivery-of-clobitasol-propionate-and-calcipotriol-in-psoriasis
#17
Amanpreet Kaur, Sameer S Katiyar, Varun Kushwah, Sanyog Jain
Current work reports the development and optimization of clobitasol propionate (CP) and calcipotriol (CT) loaded nanoemulsion based gel for topical treatment of psoriasis. Components of nanoemulsion viz., oil and surfactant/co-surfactant were selected depending upon solubility and emulsification potential respectively. The optimized ratio of 5:3:2 of Capmul MCM C8 EP, Cremophor RH 40 and Labrafil 1944 CS was selected. Carbopol 980 was used as gelling agent to achieve final drug concentration of 0.05% w/w and 0...
March 1, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28255351/tracking-perfluorocarbon-nanoemulsion-delivery-by-19-f-mri-for-precise-high-intensity-focused-ultrasound-tumor-ablation
#18
Soo Hyun Shin, Eun-Joo Park, Changki Min, Sun Il Choi, Soyeon Jeon, Yun-Hee Kim, Daehong Kim
Perfluorocarbon nanoemulsions (PFCNEs) have recently been undergoing rigorous study to investigate their ability to improve the therapeutic efficacy of tumor ablation by high intensity focused ultrasound (HIFU). For precise control of PFCNE delivery and thermal ablation, their accumulation and distribution in a tumor should be quantitatively analyzed. Here, we used fluorine-19 ((19)F) magnetic resonance imaging (MRI) to quantitatively track PFCNE accumulation in a tumor, and analyzed how intra-tumoral PFCNE quantities affect the therapeutic efficacy of HIFU treatment...
2017: Theranostics
https://www.readbyqxmd.com/read/28254284/novel-ultrasound-responsive-chitosan-perfluorohexane-nanodroplets-for-image-guided-smart-delivery-of-an-anticancer-agent-curcumin
#19
Fatemeh Baghbani, Mahdieh Chegeni, Fathollah Moztarzadeh, Samaneh Hadian-Ghazvini, Majid Raz
Ultrasound-responsive nanodroplets are a class of new emerging smart drug delivery systems which provide image-guided nano-therapy of various diseases, especially cancers. Here, we developed multifunctional smart curcumin-loaded chitosan/perfluorohexane nanodroplets for contrast-ultrasound imaging and on-demand drug delivery. The nanodroplets were synthesized via nanoemulsion process. The optimal formulation with the size of 101.2nm and 77.8% curcumin entrapment was chosen for release study and cytotoxicity evaluation...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28242906/long-term-stability-of-sodium-caseinate-stabilized-nanoemulsions
#20
Manispuritha Yerramilli, Supratim Ghosh
Oil-in-water (5 wt%) nanoemulsions were prepared with different concentration (2.5-10 wt%) of sodium caseinate as a sole emulsifier and their long-term storage stability was investigated for 6 months. Previous studies associated with sodium caseinate looked only into nanoemulsion formation; hence the challenges with long-term stability were not addressed. All nanoemulsions displayed an average droplet size <200 nm, which remained unchanged over 6 months. However, all of them displayed rapid creaming due to unabsorbed protein induced depletion flocculation, whose extent increased with protein concentration, although the cream layer formed was weak and re-dispersible upon gentle mixing...
January 2017: Journal of Food Science and Technology
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