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https://www.readbyqxmd.com/read/28820568/enhanced-drug-delivery-into-cell-cytosol-via-glycoprotein-h-derived-peptide-conjugated-nanoemulsions
#1
Teresa Fotticchia, Raffaele Vecchione, Pasqualina Liana Scognamiglio, Daniela Guarnieri, Vincenzo Calcagno, Concetta Di Natale, Chiara Attanasio, Maria De Gregorio, Chiara Di Cicco, Vincenzo Quagliariello, Nicola Maurea, Antonio Barbieri, Luca Raiola, Rosario Vincenzo Iaffaioli, Paolo Antonio Netti
The key role of nanocarriers in improving the pharmacological properties of commonly used drugs is recognized worldwide. It is also known that in the development of new effective nanocarriers the use of targeting moieties integrated on their surface is essential. Herein, we propose a nanocarrier based on an oil in water nanoemulsion coated with a membranotropic peptide derived from the glycoprotein H of Herpes simplex virus 1, known as gH625, in order to reduce endo-lysosomal accumulation and to enhance cytosolic localization...
August 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28815766/preparation-of-robust-metal-free-magnetic-nanoemulsions-encapsulating-low-molecular-weight-nitroxide-radicals-and-hydrophobic-drugs-directed-toward-mri-visible-targeted-delivery
#2
Rui Tamura, Kota Nagura, Yusa Takemoto, Satori Moronaga, Yoshiaki Uchida, Satoshi Shimono, Akihiko Shiino, Kenji Tanigaki, Tsukuru Amano, Fumi Yoshino, Yohei Noda, Satoshi Koizumi, Naoki Komatsu, Tatsuhisa Kato, Jun Yamauchi
With a view to developing a theranostic nanomedicine for magnetic resonance (MR) imaging-visible targeted drug delivery system, robust metal-free magnetic nanoemulsions (mean particle sizes of less than 20 nm) consisting of the biocompatible surfactant 1 and the incorporated hydrophobic low-molecular-weight 2,2,5-trimethyl-5-(4-alkoxy)phenylpyrrolidine-N-oxyl radicals [(±)-2] have been prepared in pH 7.4 phosphate-buffered saline. The structure of the nanoemulsions has been characterized by electron paramagnetic resonance spectroscopy, and dynamic light scattering and small angle neutron scattering measurements...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28809443/characterisation-in-vitro-and-in-vivo-evaluation-of-valproic-acid-loaded-nanoemulsion-for-improved-brain-bioavailability
#3
Suk Fei Tan, Brian P Kirby, Johnson Stanslas, Hamidon Bin Basri
OBJECTIVE: This study was aimed to investigate the potential of formulated valproic acid-encapsulated nanoemulsion (VANE) to improve the brain bioavailability of valproic acid (VPA). METHODS: Valproic acid-encapsulated nanoemulsions were formulated and physically characterised (osmolarity, viscosity, drug content, drug encapsulation efficiency). Further investigations were also conducted to estimate the drug release, cytotoxic profile, in-vitro blood-brain barrier (BBB) permeability, pharmacokinetic parameter and the concentration of VPA and VANE in blood and brain...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28807819/carrier-characteristics-influence-the-kinetics-of-passive-drug-loading-into-lipid-nanoemulsions
#4
Katrin Göke, Heike Bunjes
Passive loading as a novel screening approach is a material-saving tool for the efficient selection of a suitable colloidal lipid carrier system for poorly water soluble drug candidates. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles after removal of excess drug. For reliable routine use and to obtain meaningful loading results, information on the kinetics of the process is required. Passive loading proceeds via a dissolution-diffusion based mechanism, where drug surface area and drug water solubility are key parameters for fast passive loading...
August 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28805098/assessment-of-the-permeability-and-toxicity-of-polymeric-nanocapsules-using-the-zebrafish-model
#5
Carmen Teijeiro-Valiño, Elena Yebra-Pimentel, Jorge Guerra-Varela, Noemi Csaba, María J Alonso, Laura Sánchez
AIM: To assess the capacity of a new drug delivery nanocapsule (NC) with a double shell of hyaluronic acid and protamine to overcome biological barriers using the zebrafish model. MATERIALS & METHODS: NCs were prepared by the solvent displacement method, tagged with fluorescent makers and physicochemically characterized. Toxicity was evaluated according to the Fish Embryo Acute Toxicity test, and permeability was tested by exposing zebrafish, with and without chorion, to the fluorescent NCs...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28805092/a-review-of-bf-200-ala-for-the-photodynamic-treatment-of-mild-to-moderate-actinic-keratosis
#6
Uwe Reinhold
BF-200 ALA is a combination of a nanoscale-lipid vesicle formulation and the prodrug 5-aminolevulinic acid (5-ALA). The nanoemulsion stabilizes the prodrug and enhances its penetration through the stratum corneum. It has shown excellent therapeutic results in both lesion and field-directed photodynamic therapy of actinic keratosis (AK). AK is an early form of epidermal neoplasia and a precursor of invasive cutaneous squamous cell carcinoma. It is characterized by the combination of visible neoplastic lesions and surrounding tissue also harboring tumorigenic UV-induced mutations: a concept called field cancerization...
August 14, 2017: Future Oncology
https://www.readbyqxmd.com/read/28803993/nanoemulsion-formulation-of-a-novel-taxoid-dha-sbt-1214-inhibits-prostate-cancer-stem-cell-induced-tumor-growth
#7
Gulzar Ahmad, Rana El Sadda, Galina Botchkina, Iwao Ojima, James Egan, Mansoor Amiji
The main aim of this study was to evaluate the therapeutic efficacy of an oil-in-water nanoemulsion formulation encapsulating DHA-SBT-1214, a novel omega-3 fatty acid conjugated taxoid prodrug, against prostate cancer stem cells. Nanoemulsions of DHA-SBT-1214 (NE-DHA-SBT-1214) were prepared and characterized. In vitro delivery efficiency and cytotoxicity of NE-DHA-SBT-1214 was compared with solution formulation in PPT2 cells. In vivo studies included analysis of comparative efficacy of NE-DHA-SBT-1214 with Abraxane(®) and placebo nanoemulsions as well as post-treatment alternations in clonogenic and sphere-forming capabilities of the tumor cells...
August 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28800465/oil-based-cyclo-oligosaccharide-nanodevices-for-drug-encapsulation
#8
Jennifer Noro, Ana Loureiro, Filipa Gonçalves, Nuno G Azoia, Seunho Jung, Carla Silva, Artur Cavaco-Paulo
New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (∼50°C) and when submitted to ultrasound (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28798803/preparation-of-a-nanoemulsion-with-carapa-guianensis-aublet-meliaceae-oil-by-a-low-energy-solvent-free-method-and-evaluation-of-its-preliminary-residual-larvicidal-activity
#9
Flávia L M Jesus, Fernanda B de Almeida, Jonatas L Duarte, Anna E M F M Oliveira, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Regina Gendzelevski Kelmann, José C T Carvalho, Ana C Lira-Guedes, Marcelino Guedes, Conxita Solans, Caio P Fernandes
Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpenoids)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28775257/sers-investigation-of-cancer-cells-treated-with-pdt-quantification-of-cell-survival-and-follow-up
#10
A B Veloso, J P F Longo, L A Muehlmann, B F Tollstadius, P E N Souza, R B Azevedo, P C Morais, S W da Silva
In this study Surface Enhanced Raman Spectroscopy (SERS) data recorded from mouse mammary glands cancer cells (4T1 cell line) was used to assess information regarding differences between control, death and viable cells after Photodynamic Therapy (PDT) treatment. The treatment used nanoemulsions (NE/PS) loaded with different chloroaluminumphthalocyanine (ClAlP) photosensitizer (PS) contents (5 and 10 µmol × L(-1)) and illumination (660 nm wavelength) at 10 J × cm(-2) (10 minutes). The SERS data revealed significant molecular alterations in proteins and lipids due to the PDT treatment...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774560/a-novel-nanoemulsion-vaccine-induces-mucosal-interleukin-17-responses-and-confers-protection-upon-mycobacterium-tuberculosis-challenge-in-mice
#11
Mushtaq Ahmed, Douglas M Smith, Tarek Hamouda, Javier Rangel-Moreno, Ali Fattom, Shabaana A Khader
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is contracted via aerosol infection, typically affecting the lungs. Mycobacterium bovis bacillus Calmette-Guerin (BCG) is the only licensed vaccine and has variable efficacy in protecting against pulmonary TB. Additionally, chemotherapy is associated with low compliance contributing to development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Thus, there is an urgent need for the design of more effective vaccines against TB...
July 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28770920/injectable-thermosensitive-magnetic-nanoemulsion-hydrogel-for-multimodal-imaging-guided-accurate-thermoablative-cancer-therapy
#12
Haoan Wu, Lina Song, Ling Chen, Yixin Huang, Yang Wu, Fengchao Zang, Yanli An, Hanbai Lyu, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Ferrofluid-based magnetic hyperthermia of cancers has gained significant attention in recent years due to its excellent efficacy, few deleterious side effects and unlimited tissue penetration capacity. However, the high tumor osmotic pressure causes injection leakage and thus position imprecision because of the fluidity of the ferrofluid and the absence of multimodal imaging guidance, which create tremendous challenges for clinical application. Here, a body temperature-induced gelation strategy is constructed for accurate localized magnetic tumor regression based on the unique behaviors of a magnetic nanoemulsion hydrogel (MNH) within tumors...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28767108/bioorganometallic-ferrocene-tripeptide-nanoemulsions
#13
Xuejiao Yang, Yuefei Wang, Wei Qi, Rongxin Su, Zhimin He
We demonstrate an effective strategy to prepare highly stable nanoemulsions using ferrocene-modified tripeptides. Compared with traditional nanoemulsions, bioorganometallic peptide nanoemulsions are appealing for a number of reasons, including long-term and outstanding thermal stability, redox activity and biocompatibility. The formed nanoemulsions could remain stable for more than four months at room temperature, which is the highest stability reported so far for peptide and protein emulsifiers. The phase behaviour and size distribution of the emulsions could be precisely tailored by altering the temperature, solvent ratio and redox state of the ferrocene moiety...
August 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28764048/effect-of-lentil-proteins-isolate-concentration-on-the-formation-stability-and-rheological-behavior-of-oil-in-water-nanoemulsions
#14
Maja Primozic, Akaysha Duchek, Michael Nickerson, Supratim Ghosh
The formation, stability and rheology of 5wt% oil-in-water nanoemulsions as a function of lentil protein isolate concentration (0.5-5wt%) at pH 3.0 was investigated for 28days. All nanoemulsions, except 1wt% protein, showed bimodal droplet size distribution where the larger diameter peak was ascribed to protein aggregates and entrapped oil droplets. The average droplet size for all nanoemulsions measured from the lower diameter peak ranged from 161 to 357nm, which did not change over 28days. Stable flowable nanoemulsions were formed at 1-2wt% protein concentrations...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28760977/molecular-characterization-of-water-and-surfactant-aot-at-nanoemulsion-surfaces
#15
Jennifer K Hensel, Andrew P Carpenter, Regina K Ciszewski, Brandon K Schabes, Clive T Kittredge, Fred G Moore, Geraldine L Richmond
Nanoemulsions and microemulsions are environments where oil and water can be solubilized in one another to provide a unique platform for many different biological and industrial applications. Nanoemulsions, unlike microemulsions, have seen little work done to characterize molecular interactions at their surfaces. This study provides a detailed investigation of the near-surface molecular structure of regular (oil in water) and reverse (water in oil) nanoemulsions stabilized with the surfactant dioctyl sodium sulfosuccinate (AOT)...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28759302/evaluation-of-clinical-efficacy-and-safety-of-a-novel-cyclosporin-a-nanoemulsion-in-the-treatment-of-dry-eye-syndrome
#16
Hyun Seung Kim, Tae-Im Kim, Jin Hyoung Kim, Kyung Chul Yoon, Joon Young Hyon, Ko Un Shin, Chul Young Choi
PURPOSE: Topical administration of the anti-inflammatory agent cyclosporin A (CsA) is recommended for long-term management of dry eye syndrome (DES), yet standard ophthalmic CsA preparations have been reported to be unstable. In this trial, the efficacy and safety of Clacier™ (based on a phase 3 study developed by Huons Co. Ltd.), a novel 0.05% CsA nanoemulsion formulation, are compared with those of the conventional Restasis(®) emulsion. METHODS: Patients with moderate-to-severe DES were randomly assigned to receive topical 0...
July 31, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28756272/novel-nanosystems-for-the-treatment-of-ocular-inflammation-current-paradigms-and-future-research-directions
#17
REVIEW
Lida Lalu, Vishakha Tambe, Deepak Pradhan, Kritika Nayak, Suchandra Bagchi, Rahul Maheshwari, Kiran Kalia, Rakesh Kumar Tekade
Ocular discomforts involve anterior/posterior-segment diseases, symptomatic distress and associated inflammations and severe retinal disorders. Conventionally, the formulations such as eye drops, eye solutions, eye ointments and lotions, etc. were used as modalities to attain relief from such ocular discomforts. However, eye allows limited access to these traditional formulations due to its unique anatomical structure and dynamic ocular environment and therefore calls for improvement in disease intervention...
July 26, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28748562/visualization-of-macrophage-recruitment-in-head-and-neck-carcinoma-model-using-fluorine-19-magnetic-resonance-imaging
#18
Aman Khurana, Fanny Chapelin, Hongyan Xu, Joseph R Acevedo, Alfred Molinolo, Quyen Nguyen, Eric T Ahrens
PURPOSE: To evaluate the role of infiltrating macrophages in murine models of single and double mutation head and neck tumors using a novel fluorine-19 ((19) F) MRI technology. METHODS: Tumor cell lines single-hit/SCC4 or double-hit/Cal27, with mutations of TP53 and TP53 & FHIT, respectively, were injected bilaterally into the flanks of (n = 10) female mice. With tumors established, perfluorocarbon nanoemulsion was injected intravenously, which labels in situ predominantly monocytes and macrophages...
July 26, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28747860/lipolytic-efficacy-of-alginate-double-layer-nanoemulsion-containing-oleoresin-capsicum-in-differentiated-3t3-l1-adipocytes
#19
Mak-Soon Lee, Sunyoon Jung, Yoonjin Shin, Seohyun Lee, Chong-Tai Kim, In-Hwan Kim, Yangha Kim
Background: Oleoresin capsicum (OC) is an organic extract from fruits of the genus Capsicum, and has been reported to have an anti-obesity effect. Objective: This study comparatively investigated lipolytic effects of single-layer nanoemulsion (SN) and alginate double-layer nanoemulsion (AN) containing OC in 3T3-L1 adipocytes. Methods: SN and AN were compared by analyzing the intracellular lipid accumulation, triglyceride (TG) content, release of free fatty acids (FFAs) and glycerol, and mRNA expression of genes related to adipogenesis and lipolysis were analyzed in fully differentiated 3T3-L1 adipocytes...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28738427/nanoemulsion-an-advanced-vehicle-for-efficient-drug-delivery
#20
Asad Ali, Vaseem Ahamad Ansari, Usama Ahmad, Juber Akhtar, Afroz Jahan
Advanced drug delivery system has now gained preference over the conventional drug delivery system. One such research is nanoemulsion which is famous among the researchers because of ease of formation, stability, clarity, increased absorption rate leading to increasing in bioavailability and potential to form a formulation with both lipophilic as well as the hydrophilic drug. Long lasting stability (up to years) and ability to encapsulate both lipophilic and hydrophilic drug has given this colloidal system a valuable position in drug delivery...
July 24, 2017: Drug Research
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