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Ying Shao, Chunhua Wu, Tiantian Wu, Yuan Li, Shiguo Chen, Chunhong Yuan, Yaqin Hu
Eugenol is widely used in food industries where it encounters major concerns such as its poor solubility and stability. Herein, a novel eugenol-nanoemulsion was prepared by using ultrasonication as emulsification techniques, chitosan nanoparticle as carrier, and surfactant, as emulsifier. The results indicated that droplet size and encapsulation efficiency of the nanoemulsions was significantly affected by testing factors. The selected parameters for nanoemulsions were determined as chitosan-eugenol ratio of 1:1, Tween20 1 wt/v%, ultrasonic power 450 W and ultrasonic time 6 min...
August 1, 2018: Carbohydrate Polymers
D S S Valentim, J L Duarte, A E M F M Oliveira, R A S Cruz, J C T Carvalho, C Solans, C P Fernandes, M Tavares-Dias
Monogeneans are ectoparasites that may cause losses in production and productivity in the aquaculture of Colossoma macropomum. Chemotherapeutics used in aquaculture usually have major adverse effects on fish; hence, the use of essential oils has been considered advantageous, but these are not soluble in water. Thus, the use of nanostructures to enhance water solubility of compounds and improve bioactivity may be very promising. This study investigated the antiparasitic activity of nanoemulsion prepared with Copaifera officinalis oleoresin (50, 100, 150, 200 and 300 mg/L), against monogenean parasites from the gills of C...
May 16, 2018: Journal of Fish Diseases
Yun-Cheng Li, Geng Zhong, Fan-Bing Meng, Hua Yu, Da-Yu Liu, Lian-Xin Peng
BACKGROUND: Konjac glucomannan octenyl succinate (KGOS) has excellent emulsification properties and can potentially be used in the food industry as an emulsifier, stabilizer and microcapsule wall material. In present study, the in vitro digestion properties and emulsification capability and stability of KGOS were studied to evaluate the transport and encapsulation characteristics of KGOS to insoluble bioactive nutrients. RESULTS: Confocal scanning laser microscopy (CSLM) suggested that oil droplets could be encapsulated by KGOS into regular spheres...
May 15, 2018: Journal of the Science of Food and Agriculture
Myla Lôbo de Souza, Douglas Dourado Oliveira, Neila de Paula Pereira, Denis Melo Soares
Skin disease is one of the most common human diseases and affects between 30% and 70% of individuals, which requires a lot of attention to their treatments. The delivery of active pharmacological ingredients at the topical level is a challenge because of the difficulties in overcoming the mechanical barrier created by the skin and reaching greater depths, since delivery specificities are decisive for the degree of effectiveness. In this way, the nanoemulsions emerge as a potential system for the incorporation of active substances in the cells and for the controlled release of active principles...
May 15, 2018: International Journal of Dermatology
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Malene Aaby Neustrup, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Camilla Foged, Dennis Christensen
There is an unmet medical need for new subunit vaccines that induce cytotoxic T-lymphocyte (CTL) responses to prevent infection with a number of pathogens. However, stimulation of CTL responses via clinically acceptable subcutaneous (s.c.) and intramuscular (i.m.) injection is challenging. Recently, we designed a liposomal adjuvant [cationic adjuvant formulation (CAF)09] composed of the cationic lipid dimethyldioctadecylammonium (DDA) bromide, a synthetic monomycoloyl glycerol analog and polyinosinic:polycytidylic acid, which induce strong CTL responses to peptide and protein antigens after intraperitoneal administration...
2018: Frontiers in Immunology
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
Jing Yang, Xian Jun Loh, Beng Hoon Tan, Zibiao Li
A smart and recyclable oil absorber based on pH-responsive block copolymer modified magnetic nanoparticles is constructed for effective separation of oil-in-water emulsions. Superparamagnetic iron(III) oxide (Fe3 O4 ) nanoparticles are designed as the core materials for providing the separation force, and surface modification with poly(4-vinylpyridine-b-dimethyl siloxane-b-4-vinylpyridine) (P4VP-PDMS-P4VP) block copolymer is performed to supply switchable oil wettability. The mean hydrodynamic radius of the nanoparticles increases from 43...
May 11, 2018: Macromolecular Rapid Communications
Chandra Bhushan Tripathi, Poonam Parashar, Malti Arya, Mahendra Singh, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
Breast cancer is the most common cancer of occurrence in women and has the highest mortality incidence rate therein. The present study envisaged to develop doxorubicin (Dox) loaded folate functionalized nanoemulsion (NE) for profound therapeutic activity against mammary gland cancer. NE was prepared using pseudo-ternary phase diagrams utilizing α-linolenic acid (ALA) as lipid phase, to further enhance the anticancer potential of Dox. Box-Behnken design was employed to systematically develop the NE. Optimized NE (f-Dox-NE) was evaluated for in vitro and in vivo performance...
May 10, 2018: Drug Delivery and Translational Research
Eunryel Nam, Saejong Yoo, Hwi-Yool Kim, Young-Rok Kim, Yun Jung Heo
Men's sexual health can have significant effects on a man's self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis...
May 9, 2018: Scientific Reports
Zhang Chen, Gaofeng Shu, Noamane Taarji, Colin J Barrow, Mitsutoshi Nakajima, Nauman Khalid, Marcos A Neves
The formulation, physicochemical stability and bioaccessibility of astaxanthin (AST) loaded oil-in-water nanoemulsions fabricated using gypenosides (GPs) as natural emulsifiers was investigated and compared with a synthetic emulsifier (Tween 20) that is commonly applied in food industry. GPs were capable of producing nanoemulsions with a small volume mean diameter (d4,3  = 125 ± 2 nm), which was similar to those prepared using Tween 20 (d4,3  = 145 ± 6 nm) under the same high-pressure homogenization conditions...
September 30, 2018: Food Chemistry
Niravkumar R Patel, Aleksandr Piroyan, Srinivas Ganta, Allison B Morse, Katie M Candiloro, April L Solon, Abbegail H Nack, Corin A Galati, Collete Bora, Marisa A Maglaty, Shane W O'Brien, Samuel Litwin, Barbara Davis, Denise C Connolly, Timothy P Coleman
Ovarian cancer ranks fifth in cancer related deaths for women in USA. The high mortality rate associated with ovarian cancer is due to diagnosis at later stages of disease and the high recurrence rate of 60-80%. Recurrent ovarian cancers are more likely to present as multidrug resistance (MDR) leading to unfavorable response from 2nd and 3rd line chemotherapy. Nanoemulsions (NEs) are emerging as an attractive drug delivery system to overcome MDR challenges. NEs can also minimize exposure of therapeutic cargo to normal tissues potentially reducing side effects...
May 8, 2018: Cancer Biology & Therapy
Yang Li, Chang-Ling Wu, Jun Liu, Ying Zhu, Xiao-Yuan Zhang, Lian-Zhou Jiang, Bao-Kun Qi, Xiao-Nan Zhang, Zhong-Jiang Wang, Fei Teng
The nanoemulsions of soy protein isolate-phosphatidylcholine (SPI-PC) with different emulsion conditions were studied. Homogenization pressure and homogenization cycle times were varied, along with SPI and PC concentration. Evaluations included turbidity, particle size, ζ-potential, particle distribution index, and turbiscan stability index (TSI). The nanoemulsions had the best stability when SPI was at 1.5%, PC was at 0.22%, the homogenization pressure was 100 MPa and homogenization was performed 4 times...
May 7, 2018: Nanomaterials
Siti Norhawani Harun, Syafinaz Amin Nordin, Siti Salwa Abd Gani, Ahmad Fuad Shamsuddin, Mahiran Basri, Hamidon Bin Basri
Background and aim: Drugs that are effective against diseases in the central nervous system and reach the brain via blood must pass through the blood-brain barrier (BBB), a unique interface that protects against potential harmful molecules. This presents a major challenge in neuro-drug delivery. This study attempts to fabricate the cefuroxime-loaded nanoemulsion (CLN) to increase drug penetration into the brain when parenterally administered. Methods: The nanoemulsions were formulated using a high-pressure homogenization technique and were characterized for their physicochemical properties...
2018: International Journal of Nanomedicine
Mercedes Peleteiro, Elena Presas, Jose Vicente González-Aramundiz, Beatriz Sánchez-Correa, Rosana Simón-Vázquez, Noemi Csaba, María J Alonso, África González-Fernández
The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades. In an effort to gain a deeper understanding of the interactions between these systems and immunocompetent cells, we describe here a systematic in vitro and in vivo study on three types of polymeric nanocapsules (NCs). These carriers, which contained protamine (PR), polyarginine (PARG), or chitosan (CS) in the external shell, and their corresponding nanoemulsion were prepared, and their main physicochemical properties were characterized...
2018: Frontiers in Immunology
Kamilia Kemel, Sana Tfaili, Ali Tfayli, Arlette Baillet-Guffroy, Vincent Faivre, Cécile Laugel
The present work deals with original bi-compartmental lipid Janus nanoparticles (JNP) which are characterized by the presence of an oily compartment associated with an aqueous compartment delimited by a phospholipid-based bilayer. The size of JNP varies between 150 and 300 nm. As JNP are promising candidates for cutaneous application, the purpose of this study was to implement reliable infrared descriptors over time of JNP, in order to follow the physical stability of JNP in open air and over time. Therefore, a comparative study with the nanoemulsion (NE) and the physical mixture (PM) formulations was conducted by attenuated total reflection by Fourier transform infrared spectroscopy (ATR-FTIR)...
April 30, 2018: Journal of Pharmaceutical Sciences
Karthikeyan Ramalingam, Valerie A Lee
Acinetobacter baumannii have evolved as an exceedingly troublesome pathogenic microorganisms and prevention and controlling this pathogen is considered to be a public health problem. Nanoemulsions (NE) are a distinctive type of decontaminator produced by integration of immiscible oil phase with aqueous phase under extreme shear forces. The effectiveness of NEs and their components was determined against four stains of A. baumannii by MBC, adherence assay, biofilm assay and SEM studies. NE dilutions ranging from 125 to 225 reduced adhesion by from 61...
May 2, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Andrea Steinhaus, Théophile Pelras, Ramzi Chakroun, André H Gröschel, Markus Müllner
Understanding the self-assembly behavior of polymers of various topologies is key to a reliable design of functional polymer materials. Self-assembly under confinement conditions emerges as a versatile avenue to design polymer particles with complex internal morphologies while simultaneously facilitating scale-up. However, only linear block copolymers have been studied to date, despite the increasing control over macromolecule composition and architecture available. This study extends the investigation of polymer self-assembly in confinement from regular diblock copolymers to diblock molecular polymer brushes (MPBs)...
May 2, 2018: Macromolecular Rapid Communications
Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Objective of the present study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route improving its bioavailability. Antioxidant activity, pharmacokinetic parameters and dopamine concentration were determined. Oxidative stress models which had Parkinson's disease like symptoms were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. The antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and reducing power assay which showed high scavenging efficiency for selegiline nanoemulsion compared to pure selegiline...
May 2, 2018: Rejuvenation Research
Ahmed S Hashem, Samir S Awadalla, Gamal M Zayed, Filippo Maggi, Giovanni Benelli
The red flour beetle, Tribolium castaneum Herbst (Coleoptera: Tenebrionidae), is an economically important pest of stored products. As possible alternative to conventional insecticides for its management, plant essential oils have gained interest owing to their effectiveness and eco-friendly features. However, they also show some drawbacks, such as low stability, poor water solubility and diffusion, and limited persistence in the environment. A good strategy to overcome these disadvantages is represented by green nanotechnologies...
April 30, 2018: Environmental Science and Pollution Research International
Jing Wan, Shaobin Zhong, Paul Schwarz, Bingcan Chen, Jiajia Rao
The influence of oil composition on the physical properties and antifungal and mycotoxin inhibitory activity of clove oil-in-water nanoemulsions was investigated. Physically stable clove oil-in-water nanoemulsions could be fabricated by incorporating either ≥75 wt% of corn oil or ≥50 wt% of medium chain triacylglycerol (MCT) into clove oil before homogenization to prevent Ostwald ripening. The clove oil-in-water nanoemulsions with mean diameters of <150 nm showed high physical stability over 30 days storage...
May 1, 2018: Food & Function
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