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Noor Hafizah Arbain, Norazlinaliza Salim, Hamid Reza Fard Masoumi, Tin Wui Wong, Mahiran Basri, Mohd Basyaruddin Abdul Rahman
Bioavailability of quercetin, a flavonoid potentially known to combat cancer, is challenging due to hydrophobic nature. Oil-in-water (O/W) nanoemulsion system could be used as nanocarrier for quercertin to be delivered to lung via pulmonary delivery. The novelty of this nanoformulation was introduced by using palm oil ester/ricinoleic acid as oil phase which formed spherical shape nanoemulsion as measured by transmission electron microscopy and Zetasizer analyses. High energy emulsification method and D-optimal mixture design were used to optimize the composition towards the volume median diameter...
March 14, 2018: Drug Delivery and Translational Research
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Ashay Jain, Rajeev Tyagi, Sanjay Chhibber, Om P Katare
AIM: The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection. MATERIALS & METHODS: The developed carriers were characterized for particle size, antibacterial activity, cell viability assay in HaCat cell lines, rheological profile, ex vivo and in vivo studies, namely, full thickness MRSA 33591 murine burn wound infection via topical route...
March 12, 2018: Nanomedicine
Songling Han, Huijie An, Hui Tao, Lanlan Li, Yuantong Qi, Yongchang Ma, Xiaohui Li, Ruibing Wang, Jianxiang Zhang
We demonstrate that the traditional emulsification theory can be enriched by a self-assembly approach, in which hydrophilic copolymers with one block exhibiting noncovalent forces with the oil phase self-assemble at the oil-water interface, thereby reducing interfacial tension and forming emulsions. This approach was established using affinity diblock copolymers that can interact with oil molecules through electrostatic interactions or hydrogen-bonding. Nanoemulsions with excellent stability were successfully obtained simply via vortexing...
March 12, 2018: Chemical Communications: Chem Comm
Gulzar Ahmad, Florence Gattacecca, Rana El Sadda, Galina Botchkina, Iwao Ojima, James Egan, Mansoor Amiji
PURPOSE: The main purpose of this study was to formulate an oil-in-water nanoemulsion of a next generation taxoid DHA-SBT-1214 and evaluate its biodistribution and pharmacokinetics. METHODS: DHA-SBT-1214 was encapsulated in a fish oil containing nanoemulsion using a high pressure homogenization method. Following morphological characterization of the nanoemulsions, qualitative and quantitative biodistribution was evaluated in naïve and cancer stem cell-enriched PPT-2 human prostate tumor bearing mice...
March 8, 2018: Pharmaceutical Research
Jelena M Janjic, Kiran Vasudeva, Muzamil Saleem, Andrea Stevens, Lu Liu, Sravan Patel, John A Pollock
Neuroinflammation involving macrophages elevates Prostaglandin E2 , associated with neuropathic pain. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) inhibits cyclooxygenase, reducing PGE2 . However, NSAIDs cause physiological complications. We developed nanoemulsions incorporating celecoxib and near infrared dye. Intravenous injected nanoemulsion is incorporated into monocytes that accumulate at the injury; revealed in live animals by fluorescence. A single dose (celecoxib 0.24 mg/kg) provides targeted delivery in chronic constriction injury rats, resulting in significant reduction in the visualized inflammation, infiltration of macrophages, COX-2 and PGE2 ...
February 25, 2018: Journal of Neuroimmunology
Alessandra Regina Dhorm Pimentel de Moraes, Guilherme Diniz Tavares, Francisca Janaina Soares Rocha, Eneida de Paula, Selma Giorgio
Plant products are an important source of bioactive agents against parasitic diseases, including leishmaniasis. Among these products, vegetable oils have gained ground in the pharmaceutical field. Here we report the development of nanoemulsions as a delivery system for copaiba and andiroba oils (nanocopa and nanoandi) in order to test their effects on Leishmania infantum and L. amazonensis. The nanocopa and nanoandi had an average particle size of 76.1 and 88.1, respectively with polydispersity index 0.14 to 0...
March 5, 2018: Experimental Parasitology
Heni Rachmawati, Yang Aryani Arvin, Sukmadjaja Asyarie, Kusnandar Anggadiredja, Raymond Rubianto Tjandrawinata, Gert Storm
Bupivacaine HCl (1-butyl-2',6'-pipecoloxylidide hydrochloride), an amide local anesthetic compound, is a local anesthetic drug utilized for intraoperative local anesthesia, post-operative analgesia and in the treatment of chronic pain. However, its utility is limited by the relative short duration of analgesia after local administration (approximately 9 h after direct injection) and risk for side effects. This work is aimed to develop a nanoemulsion of bupivacaine HCl with sustained local anesthetics release kinetics for improved pain management, by exhibiting extended analgesic action and providing reduced peak levels in the circulation to minimize side effects...
March 7, 2018: Drug Delivery and Translational Research
Wladimir Silva, María Fernanda Torres-Gatica, Felipe Oyarzun-Ampuero, Andrea Silva-Weiss, Paz Robert, Susana Cofrades, Begoña Giménez
The development of fat replacers to obtain healthier/functional foods is a constant challenge. With this aim, double emulsions (DE) with a blend of olive, linseed and fish oils as oil phase were developed. To prevent the oxidation of these oils, gallic acid and quercetin were incorporated in the internal and the external aqueous phase (W2 ), respectively, according to a factorial design. Considering the low solubility of quercetin in water, it was included in O/W nanoemulsions (QN), thus being freely dispersible in W2 ...
July 1, 2018: Food Chemistry
Tahir Mehmood, Anwaar Ahmed, Asif Ahmad, Muhammad Sheeraz Ahmad, Mansur Abdullah Sandhu
In the present study, food grade mixed surfactant-based β-carotene nanoemulsions were prepared without using any co-surfactant. Response surface methodology (RSM) along with central composite design (CCD) was used to investigate the effect of independent variables (surfactant concentration, ultrasonic homogenization time and oil content) on response variables. RSM analysis results revealed that experimental results were best fitted into a quadratic polynomial model with regression coefficient values of more than 0...
July 1, 2018: Food Chemistry
Venkatraman Sriramavaratharajan, Ramar Murugan
In the present study, antioxidant and anti-hyperglycemic activities of nanoemulsions of the leaf essential oils of Cinnamomum litseifolium Thwaites collected from two different locations in the Western Ghats namely, Kannikatty, Kalakad Mundandurai Tiger Reserve, Tamil Nadu (Cl1 ) and Karamanayar, Agasthyamalai hills, Kerala (Cl2 ), India were studied. Essential oils were extracted from the leaves and characterized by GC-FID and GC-MS. Slight variation in the composition of leaf essential oils was observed. Essential oil based nanoemulsions were prepared using a surfactant (Tween-80), co-surfactant (propylene glycol) and an emulsifier (lecithin) by homogenization followed by ultra-sonication...
March 2, 2018: Natural Product Research
Amanda Migotto, Vanessa F M Carvalho, Giovanna C Salata, Fernanda W M da Silva, Chao Yun Irene Yan, Kelly Ishida, Leticia V Costa-Lotufo, Alexandre A Steiner, Luciana B Lopes
Considering that breast cancer usually begins in the lining of the ducts, local drug administration into the ducts could target cancers and pre-tumor lesions locally while reducing systemic adverse effects. In this study, a cationic bioadhesive nanoemulsion was developed for intraductal administration of C6 ceramide, a sphingolipid that mediates apoptotic and non-apoptotic cell death. Bioadhesive properties were obtained by surface modification with chitosan. The optimized nanoemulsion displayed size of 46...
November 2018: Drug Delivery
María L Zambrano-Zaragoza, Ricardo González-Reza, Néstor Mendoza-Muñoz, Verónica Miranda-Linares, Tania F Bernal-Couoh, Susana Mendoza-Elvira, David Quintanar-Guerrero
Currently, nanotechnology represents an important tool and an efficient option for extending the shelf life of foods. Reducing particle size to nanometric scale gives materials distinct and improved properties compared to larger systems. For food applications, this technology allows the incorporation of hydrophilic and lipophilic substances with antimicrobial and antioxidant properties that can be released during storage periods to increase the shelf life of diverse products, including whole and fresh-cut fruits and vegetables, nuts, seeds, and cheese, among others...
March 1, 2018: International Journal of Molecular Sciences
Bijun Zeng, Anton Pj Middelberg, Adrian Gemiarto, Kelli MacDonald, Alan G Baxter, Meghna Talekar, Davide Moi, Kirsteen M Tullett, Irina Caminschi, Mireille H Lahoud, Roberta Mazzieri, Riccardo Dolcetti, Ranjeny Thomas
Non-antigen-specific stimulatory cancer immunotherapies are commonly complicated by off-target effects. Antigen-specific immunotherapy, combining viral tumor antigen or personalised neo-epitopes with immune targeting, offers a solution. However, the lack of flexible systems targeting tumor antigens to cross-presenting dendritic cells (DCs) limits clinical development. Although antigen-anti-CLEC-9A mAb conjugates target cross-presenting DCs, adjuvant must be co-delivered for cytotoxic T-cell (CTL) induction...
February 27, 2018: Journal of Clinical Investigation
David Julian McClements
There are many examples of bioactive proteins and peptides that would benefit from oral delivery through functional foods, supplements, or medical foods, including hormones, enzymes, antimicrobials, vaccines, and ACE inhibitors. However, many of these bioactive proteins are highly susceptible to denaturation, aggregation or hydrolysis within commercial products or inside the human gastrointestinal tract (GIT). Moreover, many bioactive proteins have poor absorption characteristics within the GIT. Colloidal systems, which contain nanoparticles or microparticles, can be designed to encapsulate, retain, protect, and deliver bioactive proteins...
February 16, 2018: Advances in Colloid and Interface Science
Ai M Cheong, Chin P Tan, Kar L Nyam
Kenaf ( Hibiscus cannabinus L.) seed oil has been proven for its multi-pharmacological benefits; however, its poor water solubility and stability have limited its industrial applications. This study was aimed to further improve the stability of pre-developed kenaf seed oil-in-water nanoemulsions by using food-grade ternary emulsifiers. The effects of emulsifier concentration (1, 5, 10, 15% w/w), homogenisation pressure (16,000, 22,000, 28,000 psi), and homogenisation cycles (three, four, five cycles) were studied to produce high stability of kenaf seed oil-in-water nanoemulsions using high pressure homogeniser...
January 1, 2018: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
Sunita Minz, Ravi Shankar Pandey
Pulmonary vaccination is one of the most promising routes for immunization owing to its non-invasive nature and induction of strong mucosal immunity and systemic response. In the present study, recombinant hepatitis B surface antigen loaded solid fat nanoemulsions (SFNs) as carrier system and monophosphoryl lipid A (MPLA) as an adjuvant-carrier system was prepared and evaluated as multi adjuvanted vaccine system for deep pulmonary vaccination. Deposition and clearance from the deep lung of rats were determined by gamma scintigraphy...
February 15, 2018: Journal of Pharmaceutical Sciences
Sanaz Jafarpour Azami, Amir Amani, Hossein Keshavarz, Roqya Najafi-Taher, Mehdi Mohebali, Mohammad Ali Faramarzi, Mahmood Mahmoudi, Saeedeh Shojaee
Treatment of toxoplasmosis is necessary in congenital form and immunocompromised patients. Atovaquone is a powerful suppressor of protozoan parasites with a broad-spectrum activity, but an extremely low water solubility and bioavailability. In this study, nanoemulsion of this drug was prepared with grape seed oil using spontaneous emulsification method to increase bioavailability and efficacy of atovaquone for treatment of toxoplasmosis. In vitro activity of atovaquone nanoemulsion against T. gondii, RH and Tehran strains, was assessed in HeLa cell culture...
February 13, 2018: European Journal of Pharmaceutical Sciences
Bin Xie, Yang Liu, Yuting Guo, Enbo Zhang, Chenguang Pu, Haibing He, Tian Yin, Xing Tang
PURPOSE: To prepare sustained-release PLGA/mPEG-PLGA hybrid nanoparticles of progesterone (PRG), and evaluate the descending required administration dosage in vivo. METHODS: PRG hybrid nanoparticles (PRG H-NPs) based on PLGA/mPEG-PLGA were compared with PRG nanoparticles (PRG-NPs) of pure PLGA as the matrix and PRG-oil solutions. Nanoparticles (NPs) were formed by the method of nanoemulsion, and the pharmacokinetics of the sustained-release PRG H-NPs in male Sprague dawley (SD) rats were investigated...
February 14, 2018: Pharmaceutical Research
K Habibi, H Sepehri, L Delphi, M H Mirjalili, H Rafati
Methyl jasmonate (MJ), a plant-derived stress hormone, has been shown to be a promising anti-cancer agent with high selectivity toward cancerous cells. The aim of the present study was to design a MJ loaded nanoemulsion (NE) to overcome the low MJ water solubility and also improve its anti-cancer efficiency. Box-Behnken design (BBD) was employed to optimize the composition effect of three independent manufacturing variables on two responses including average droplet size and poly dispersity index (PDI). ANOVA analysis indicated that both of the studied responses were well fitted by resultant quadratic models with the coefficient of determinations (R2) 0...
November 1, 2017: Die Pharmazie
Ching-Chi Yen, Yi-Chen Chen, Ming-Tsang Wu, Chia-Chi Wang, Yu-Tse Wu
Background: Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflammatory bowel disease. Methods: A high-pressure homogenization technique was used to prepare the AG-NE and solubility, viscosity, and droplet size tests were conducted to develop the optimized AG-NE composed of α-tocopherol, ethanol, Cremophor EL, and water...
2018: International Journal of Nanomedicine
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