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https://www.readbyqxmd.com/read/29348099/spray-dried-curcumin-nanoemulsion-a-new-road-to-improvement-of-oral-bioavailability-of-curcumin
#1
Liandong Hu, Qiaofeng Hu, Chenchen Yang
In this study a new soluble solid curcumin nanoemulsion powder was prepared using spray-drying technology to improve the solubility and bioavailability of curcumin. The liquid nanoemulsion consisted of curcumin, Capryol 90, Transcutol P, and Cremophor RH40. The solid nanoemulsion was prepared by spray-drying the liquid nanoemulsion in laboratory spray dryer, using lactose as solid carrier. The in vitro release from powder formulation was 97.6% within 15 min while the release from the curcumin crystalline was about 10%...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29342111/cytotoxicity-evaluation-of-turmeric-extract-incorporated-oil-in-water-nanoemulsion
#2
Hee Jeong Yoon, Xiaowei Zhang, Min Gyeong Kang, Gyeong Jin Kim, Sun Young Shin, Sang Hong Baek, Bom Nae Lee, Su Jung Hong, Jun Tae Kim, Kwonho Hong, Hojae Bae
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341012/biomedical-19f-mri-using-perfluorocarbons
#3
Tuba Güden-Silber, Sebastian Temme, Christoph Jacoby, Ulrich Flögel
Background-free fluorine (19F) MR imaging exhibits an excellent degree of specificity, and facilitates among others the in vivo visualization of inflammatory processes. Merging19F MR images with morphologically matching1H MR images enables the exact anatomic localization of the observed19F signal. Biochemically inert nanoemulsions of perfluorocarbons, which are known to be taken up by the macrophage/monocyte system, are widely used as contrast agents for preclinical applications. Herein, the most common protocols are described to obtain high-resolution and artifact-free19F MR images even for compounds with complex19F MR spectra...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29338580/paeonol-nanoemulsion-for-enhanced-oral-bioavailability-optimization-and-mechanism
#4
Sufei Chen, Jing Zhang, Lei Wu, Hongfei Wu, Min Dai
AIM: The aim of this work was to optimize a nanoemulsion formulation and explain its absorption mechanism in improving the oral bioavailability of paeonol. METHOD: The bioavailability of paeonol was compared between paeonol nanoemulsion group and paeonol suspension group. The in situ single-pass intestine perfusion method, in vitro everted gut sacs method, Western blot analysis and Caco-2 cell transport studies were used to investigate the absorption mechanism of nanoemulsion...
January 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29333875/ultrafast-determination-of-vitamin-e-using-lc-esi-ms-ms-for-preclinical-development-of-new-nutraceutical-formulations
#5
Noemi Villaseca-González, Virginia Rodríguez Robledo, Lucía Castro-Vázquez, María Victoria Lozano, Manuel J Santander-Ortega, Joaquín González-Fuentes, Pilar Marcos, María Del Mar Arroyo-Jiménez
AIM: We proposed a rapid and high quality method to determine α-tocopherol (α-T) in different biopharmaceutical samples using liquid chromatography-diode array detector on-line ESI-MS/MS. MATERIALS & METHODS: A working standard solution of α-T and internal standard, phenyl-5,7-dimethyl-d6-α-tocopherol, were used for optimization and validation of the method. Levels of α-T in nanoemulsions, serum and plasma samples were evaluated. RESULTS & CONCLUSION: Precision (1% for retention time, 5% for peak area and 3% for relative peak area), linearity range (among 0...
January 15, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29332602/nanoemulsion-strategy-for-ursolic-and-oleanic-acids-isolates-from-plumeria-obtusa-improves-antioxidant-and-cytotoxic-activity-in-melanoma-cells
#6
Helen L Alvarado, Ana C Calpena, Maria L Garduno-Ramirez, Raul Ortiz, Consolacion Melguizo, Jose M Prados, Beatriz Clares
BACKGROUND: Triterpenoids are an important class of natural bioactive products present in many medicinal plants. OBJECTIVE: The aim of present study is to investigate the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and ursolic acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and loaded in a nanoemulsion (NEm) system. METHOD: The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy...
January 11, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29327181/correction-to-promising-antibacterial-effects-of-silver-nanoparticle-loaded-tea-tree-oil-nanoemulsion-a-synergistic-combination-against-resistance-threat
#7
Roqya Najafi-Taher, Behnaz Ghaemi, Sharmin Kharrazi, Samira Rasoulikoohi, Amir Amani
With regrets, there is an error in the name of one of the authors which has only been noticed after publication.
January 11, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29317755/in-vitro-and-in-vivo-antitumor-potential-of-carvacrol-nanoemulsion-against-human-lung-adenocarcinoma-a549-cells-via-mitochondrial-mediated-apoptosis
#8
Imran Khan, Ashutosh Bahuguna, Pradeep Kumar, Vivek K Bajpai, Sun Chul Kang
Carvacrol is present abundantly in the essential oils of many medicinal plants and well known for its numerous biological activities. Since partial solubility in water and physicochemical instability limits its industrial uses, the present study was performed to prepare a carvacrol nanoemulsion (CANE) using an ultrasonication technique and further evaluation of its anticancer potential against human lung adenocarcinoma A549 cells. The nanoemulsion formulation was optimized by varying carvacrol and polysorbate 80 ratios and characterized by dynamic light scattering (DLS), which revealed a negative surface charge with a mean droplet size between 105...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317346/protein-corona-and-phospholipase-activity-drive-selective-accumulation-of-nanomicelles-in-atherosclerotic-plaques
#9
Ana V Lechuga-Vieco, Hugo Groult, Juan Pellico, Jesús Mateo, Jose A Enríquez, Jesús Ruiz-Cabello, Fernando Herranz
ApoB-100 and Phosphatidylcholine-specific phospholipase C (PC-PLC) are important contributors to atherosclerosis development. ApoB-100 is the main structural protein of LDL, being directly associated with atherosclerosis plaque generation. PC-PLC is highly expressed in atherosclerosis lesions and contributes to their progression. We show how phosphatidylcholine-coated nanomicelles can be used for specific characterisation of atherosclerosis plaque. Results show that ApoB-100 in the protein corona of the nanomicelle targets the particles to atherosclerotic areas in apolipoprotein E-/- mice...
January 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29310217/uhplc-ms-and-maldi-ms-study-of-aluminum-phthalocyanine-chloride-and-development-of-a-bioanalytical-method-for-its-quantification-in-nanoemulsions-and-biological-matrices
#10
Karen R Py-Daniel, Javier Calvo, Carlos M Infante C, Osmindo R Pires Junior, Sergio E Moya, Ricardo B Azevedo
Metal phthalocyanines are promising components in photodynamic therapy. Aluminum phthalocyanine chloride (AlClPc) has been used to treat oral cancer in mice, human carious tissue, lung cancer cells and other conditions. To overcome the high hydrophobicity of AlClPc, phthalocyanine is often encapsulated in nanoformulations. Despite increased usage, little is known about the pharmacokinetics and biodistribution of AlClPc. The aim of this study was the development and validation of a UHPLC-MS method for the determination of AlClPc in solution after extraction from nanoformulations and biological matrices such as plasma and tissue...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29309726/design-of-pickering-micro-and-nanoemulsions-based-on-the-structural-characteristics-of-nanocelluloses
#11
Clara Jiménez Saelices, Isabelle Capron
The development of biobased materials with lower environmental impact has seen an increased interest these last years. In this area, nanocelluloses have shown a particular interest in research and industries. Cellulose nanocrystals (CNC) and cellulose nanofibrils (CNF) are both known to stabilize oil-water interface forming the so-called Pickering emulsions which are surfactant-free, highly stable emulsions armored by a layer of solid particles. This work describes the emulsion's characteristics and properties according to particle sizes, shape and surface chemistry in order to produce controlled micro- and nano-emulsions stabilized by nanocelluloses...
January 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29307180/stable-inks-containing-upconverting-nanoparticles-based-on-an-oil-in-water-nanoemulsion
#12
Jeevan M Meruga, William M Cross, Jacob Petersen, P Stanley May, Aravind Baride, Khadijah Cessac, Jon J Kellar
An oil-in-water nanoemulsion capable of dispersing upconversion nanoparticles (UCNPs) for seven months was investigated. Negative staining transmission electron microscopy shows that the UCNPs reside in the oil phase of the nanoemulsion. Dynamic light scattering (DLS) measurements indicate that the majority of the oil volume is contained in droplets less than 1 μm in diameter. The system studied could be used to inkjet print UCNPs at least seven months after the ink was first formulated. Nanoemulsion stability was tested in the short-term, over 11 days, using an ink stability test developed for this research...
January 6, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29301277/improved-physicochemical-properties-of-yogurt-fortified-with-fish-oil-%C3%AE-oryzanol-by-nanoemulsion-technology
#13
Jinfeng Zhong, Rong Yang, Xiaoyi Cao, Xiong Liu, Xiaoli Qin
Fish oil has several dietary benefits, but its application in food formulations is limited because of its poor water-solubility, easy oxidation and strong odor. The purposes of this study were to produce a fish oil/γ-oryzanol nanoemulsion and to evaluate the effect of adding this nanoemulsion on the physicochemical and sensory characteristics of yogurts. Adding fish oil/γ-oryzanol nanoemulsion resulted in a significant reduction in the acidity and syneresis of yogurt. Yogurt with the nanoemulsion had significantly lower peroxide value (0...
January 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29296883/innate-transcriptional-effects-by-adjuvants-on-the-magnitude-quality-and-durability-of-hiv-envelope-responses-in-nhps
#14
Joseph R Francica, Daniel E Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J Flynn, Nicholas M Valiante, Padma Malyala, Susan W Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Georgia D Tomaras, Derek T O'Hagan, Alan Aderem, Galit Alter, Robert A Seder
Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody responses in nonhuman primates (NHPs) using 8 clinically based adjuvants. NHPs were immunized with a glycoprotein 140 HIV envelope protein (Env) and insoluble aluminum salts (alum), MF59, or adjuvant nanoemulsion (ANE) coformulated with or without Toll-like receptor 4 (TLR4) and 7 agonists...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29288707/improving-the-skin-penetration-and-antifebrile-activity-of-ibuprofen-by-preparing-nanoparticles-using-emulsion-solvent-evaporation-method
#15
Yiping Deng, Fengjian Yang, Xiuhua Zhao, Lu Wang, Weiwei Wu, Chang Zu, Mingfang Wu
Ibuprofen (IBU) is an effective analgesic, non-steroidal anti-inflammatory drug. Unfortunately, oral IBU can cause adverse gastrointestinal drug reactions, such as bleeding and ulcerations, and increases the risk for stomach or intestinal perforations. In this study, IBU nanoparticles (IBU-NPs) were prepared through emulsion solvent evaporation and freeze-drying to improve their solubility. IBU nanoemulsion and nanosuspension were optimized through a single-factor experiment. IBU-NPs with a mean particle size of 216...
December 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29287320/effect-of-ripening-inhibitor-type-on-formation-stability-and-antimicrobial-activity-of-thyme-oil-nanoemulsion
#16
Victor Ryu, David J McClements, Maria G Corradini, Lynne McLandsborough
The objective of this research was to study the impact of ripening inhibitor level and type on the formation, stability, and activity of antimicrobial thyme oil nanoemulsions formed by spontaneous emulsification. Oil-in-water antimicrobial nanoemulsions (10 wt%) were formed by titrating a mixture of essential oil, ripening inhibitor, and surfactant (Tween 80) into 5 mM sodium citrate buffer (pH 3.5). Stable nanoemulsions containing small droplets (d < 70 nm) were formed. The antimicrobial activity of the nanoemulsions decreased with increasing ripening inhibitor concentration which was attributed to a reduction in the amount of hydrophobic antimicrobial constituents transferred to the separated hydrophobic domain, mimicking bacterial cell membranes, by using dialysis and chromatography...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29274774/nanotherapy-for-alzheimer-s-disease-and-vascular-dementia-targeting-senile-endothelium
#17
REVIEW
Joseph S D'Arrigo
Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted "lipid-coated microbubble" [LCM]/"nanoparticle-derived" [ND] (or LCM/ND) nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine...
December 8, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29274325/hdl-acceptor-capacities-for-cholesterol-efflux-from-macrophages-and-lipid-transfer-are-both-acutely-reduced-after-myocardial-infarction
#18
Alexandre A S Soares, Thauany M Tavoni, Eliane C de Faria, Alan T Remalay, Raul C Maranhão, Andrei C Sposito
BACKGROUND: The transport of lipids from the artery wall is one of the most essential anti-atherogenic functions of high-density lipoprotein (HDL). Recent reports of changes in the HDL composition, during myocardial infarction (MI), suggest that this function may be altered. METHODS: Forty-one consecutive patients with ST-segment elevation MI enrolled at the Brasilia Heart Study were selected. The following HDL-related measures were determined upon admission (D1) and on the fifth day (D5) after MI: C-reactive protein, CETP and PLTP activity, HDL composition, efflux of cholesterol from J774 macrophages to HDL, and transfer of unesterified and esterified cholesterol, triglycerides and phospholipids from a donor nanoemulsion to HDL...
December 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29260378/%C3%AF-3-fatty-acid-synergized-novel-nanoemulsifying-system-for-rosuvastatin-delivery-in-vitro-and-in-vivo-evaluation
#19
Chandra Bhushan Tripathi, Neha Gupta, Pranesh Kumar, Ashok Kumar Singh, Vinit Raj, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Malti Arya, Shubhini A Saraf, Sudipta Saha
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was estimated by fatty acid methyl ester (FAME) analysis using gas chromatography. Solubility of RSV in Perilla frutescens oil and Cremophor EL was 25.0 ± 3.0 and 60.0 ± 5.0 mg/mL, respectively. Later, nanophasic maps and a central composite design were employed to determine the maximum nanoemulsion region and further optimize SNES in this study...
December 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29250730/nanoemulsion-of-dill-essential-oil-as-a-green-and-potent-larvicide-against-anopheles-stephensi
#20
Mahmoud Osanloo, Hassan Sereshti, Mohammad Mehdi Sedaghat, Amir Amani
Indiscriminate use of industrial larvicides causes environment pollution and resistance against the larvicides in mosquitoes. Essential oils (EOs) have many biological activities such as larvicidal effects which have been proposed as new alternatives for industrial ones. Many components of EOs are volatile, thus, should be formulated to retain their activity. Components of Dill EO were identified by GC-MS analysis. Larvicidal activity (LA) of bulk Dill EO (non-formulated) was evaluated against Anopheles stephensi in line with WHO guideline for lab tests...
December 17, 2017: Environmental Science and Pollution Research International
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