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https://www.readbyqxmd.com/read/28718823/surface-chemistry-interactions-of-cationorm-with-films-by-human-meibum-and-tear-film-compounds
#1
Georgi As Georgiev, Norihiko Yokoi, Yana Nencheva, Nikola Peev, Philippe Daull
Cationorm(®) (CN) cationic nanoemulsion was demonstrated to enhance tear film (TF) stability in vivo possibly via effects on tear film lipid layer (TFLL). Therefore the interactions of CN with human meibum (MGS) and TFLL in vitro and in vivo deserve special study. MGS and CN were spread at the air/water interface of a Langmuir surface balance to ensure a range of MGS/CN oil phase ratios: 20/1, 10/1, 5/1, 3/1, 2/1 and 1/1. The films capability to reorganize during dynamic area changes was evaluated via the surface pressure-area compression isotherms and step/relaxation dilatational rheology studies...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28714250/development-of-antimicrobial-nanoemulsion-based-delivery-systems-against-selected-pathogenic-bacteria-using-a-thymol-rich-thymus-daenensis-essential-oil
#2
Lida Ghaderi, Roya Moghimi, Atousa Aliahmadi, David Julian McClements, Hasan Rafati
AIMS: Thymol rich medicinal plants have been used in traditional medicine to relieve infectious diseases. However, the application of essential oils as medicine is limited by its low water-solubility and high vapor pressure. The objective of this study was to produce stable nanoemulsions of Thymus daenensis oil in water by preventing Ostwald ripening and phase separation. METHODS & RESULTS: The antibacterial activity of bulk and emulsified essential oil against selected pathogenic bacteria including Gram-negative (Haemophilus influenzae, Pseudomonas aeruginosa) and Gram-positive (Streptococcus pneumoniae) were investigated in the liquid and vapor phase...
July 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28712917/amphotericin-b-releasing-topical-nanoemulsion-for-the-treatment-of-candidiasis-and-aspergillosis
#3
Lilian Sosa, Beatriz Clares, Helen L Alvarado, Nuria Bozal, Oscar Domenech, Ana C Calpena
The present study was designed to develop a nanoemulsion formulation of Amphotericin B (AmB) for the treatment of skin candidiasis and aspergillosis. Several ingredients were selected on the basis of AmB solubility and compatibility with skin. The formulation that exhibited the best properties was selected from the pseudo-ternary phase diagram. After physicochemical characterization its stability was assessed. Drug release and skin permeation studies were also accomplished. The antifungal efficacy and skin tolerability of developed AmB nanoemulsion was demonstrated...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28707182/anti-inflammatory-and-antialgic-actions-of-a-nanoemulsion-of-rosmarinus-officinalis-l-essential-oil-and-a-molecular-docking-study-of-its-major-chemical-constituents
#4
Raphaelle Sousa Borges, Emerson Silva Lima, Hady Keita, Irlon Maciel Ferreira, Caio Pinho Fernandes, Rodrigo Alves Soares Cruz, Jonatas Lobato Duarte, Josué Velázquez-Moyado, Brenda Lorena Sánchez Ortiz, Andrés Navarrete Castro, Jaderson Vieira Ferreira, Lorane Izabel da Silva Hage-Melim, José Carlos Tavares Carvalho
We evaluate the anti-inflammatory and antialgic potency of a nanoemulsion (NEORO) containing the essential oil of Rosmarinus officinalis L. (EORO), which is composed primarily of limonene, camphor and 1,8-cineole. The EORO and NEORO were administered orally 30 min prior to starting the experiments. In a test of rat paw oedema induced by carrageenan, NEORO was effective in doses of 498 µg/kg, and it inhibited 46% of the maximum peak of the oedema; in a dose of 300 mg/kg, EORO inhibited 50% of the maximum peak of the oedema...
July 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28703043/acid-sensitive-lipidated-doxorubicin-prodrug-entrapped-in-nanoemulsion-impairs-lung-tumor-metastasis-in-a-breast-cancer-model
#5
Ana Lygia Dos Santos Câmara, Gregor Nagel, Harald R Tschiche, Camila Magalhães Cardador, Luis Alexandre Muehlmann, Daniela Mara de Oliveira, Paula Queiroz Alvim, Ricardo Bentes Azevedo, Marcelo Calderón, João Paulo Figueiró Longo
AIM: To develop an acid-sensitive lipidated, doxorubicin (Dox) prodrug (C16-Dox) to be entrapped in lipid nanoemulsion (NE-C16-Dox) as a nanocarrier to treat breast cancer models (in vitro and in vivo). RESULTS: We report the efficacy of NE-C16-Dox in in vitro experiments, as well as the improved chemotherapeutic index and tumor-control efficacy compared with treatment with free Dox in an in vivo murine 4T1 breast cancer model. In addition, NE-C16-Dox allowed the use of a higher dose of Dox, acceptable biocompatibility and a significant reduction in lung metastasis...
July 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28700229/fabrication-of-novel-avermectin-nanoemulsion-using-polyurethane-emulsifier-with-cleavable-disulfide-bonds
#6
Wenxun Guan, Wenxiang Zhang, Liming Tang, Yan Wang, Haixin Cui
In this study, a polyurethane emulsifer with various functional groups was prepared from isophorone diisocyanate (IPDI), avermectin, 2,2-dimethylol propionic acid (DMPA) and bis(2-hydroxyethyl) disulfide (HEDS). The chemical structure of the polymer was confirmed by FT-IR, 1H NMR and element analysis. The polymer exhibited adequate emulsification ability for avermectin after neutralization with triethylamine. A satisfaying nanoemulsion was obtained, in which avermectin was encapsulated in nanoparticles with 50 wt% drug loading, low organic solvent content and high stability under dilution and centrifuging treatment in addition to low surface tension, high affinity to crop leaf and improved avermectin photostability...
July 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28696684/development-of-beta-carotene-loaded-organogel-based-nanoemulsion-with-improved-in-vitro-and-in-vivo-bioaccessibility
#7
Yuting Fan, Luyu Gao, Jiang Yi, Yuzhu Zhang, Wallace Yokoyama
Beta-carotene (BC), a naturally occurring lipophilic carotenoid, is beneficial for human health. However, its water solubility and bioavailability is low. In this study, organogel-based nanoemulsion was successfully prepared to improve BC's loading amount, solubility, and bioavailability. Corn oil was selected as oil phase for organogel due to the greatest release amount of BC. Tween 20 was optimized as the emulsifier based on the highest extent of lipolysis and BC bioaccessibility. The nanoemulsion was a better alternative than organogel according to both the extent of lipolysis and BC bioaccessibility...
July 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28694767/development-of-a-new-rutin-nanoemulsion-and-its-application-on-prostate-carcinoma-pc3-cell-line
#8
Mohammad Ahmad, - Sahabjada, Juber Akhtar, Arshad Hussain, - Badaruddeen, Md Arshad, Anuradha Mishra
Biological effects of rutin bioactive are limited due to its poor oral bioavailability and its degradation in aqueous environments. For the purpose of bioenhancement, different nanoemulsion systems of rutin were developed by aqueous titration method using water as dispersion media. The nanoemulsion systems were characterized for surface morphology, droplet size, polydispersity index, zeta potential, in vitro release profile and the formulations were optimized. The anticancer potential of optimized nanoemulsion was evaluated by cells viability (MTT) assay, nuclear condensation, and ROS activity using human prostate cancer (PC3) cell line...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28691021/evaluation-of-stability-and-in-vitro-security-of-nanoemulsions-containing-eucalyptus-globulus-oil
#9
Samantha Nunes de Godoi, Priscilla Maciel Quatrin, Michele Rorato Sagrillo, Kátia Nascimento, Roger Wagner, Bruna Klein, Roberto Christ Vianna Santos, Aline Ferreira Ourique
Essential oil of Eucalyptus globulus presents several pharmacological properties. However, their therapeutic efficacy may be affected by limitations due to several conditions, rendering it difficult to obtain stable and effective pharmaceutical formulations. The use of nanotechnology is an alternative to improve their characteristics aiming to ensure their stability and effectiveness. Furthermore, studies about the possible toxic effects of nanostructures are necessary to evaluate safety when the formulation comes into contact with human cells...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28687053/fabrication-in-vitro-characterization-and-enhanced-in-vivo-evaluation-of-carbopol-based-nanoemulsion-gel-of-apigenin-for-uv-induced-skin-carcinoma
#10
Manmohan S Jangdey, Anshita Gupta, Swarnlata Saraf
The aim of this study was to develop a potential novel formulation of carbopol-based nanoemulsion gel containing apigenin using tamarind gum emulsifier which was having the smallest droplet size, the highest drug content, and a good physical stability for Skin delivery. Apigenin loaded nanoemulsion was prepared by high speed homogenization method and they were characterized with respect to morphology, zeta potential, differential scanning calorimeter study, and penetration studies. In-vitro release studies and skin permeation of apigenin loaded nanoemulsion by goat abdominal skin was determined using Franz diffusion cell and confocal laser scanning microscope (CLSM)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28681331/topical-delivery-of-coumestrol-from-lipid-nanoemulsions-thickened-with-hydroxyethylcellulose-for-antiherpes-treatment
#11
Débora Fretes Argenta, Juliana Bidone, Letícia Scherer Koester, Valquíria Link Bassani, Cláudia Maria Oliveira Simões, Helder Ferreira Teixeira
We have recently shown that coumestrol, an isoflavonoid-like compound naturally occurring in soybeans, alfafa, and red clover, inhibited Herpes Simplex Virus types 1 (HSV-1) and 2 (HSV-2) replication. In this study, we designed coumestrol formulations in an attempt to enable its topical delivery to mucosa tissues. Physicochemical and microscopic examinations suggested that coumestrol was efficiently incorporated in positively-charged nanoemulsions dispersed in a hydroxyethylcellulose gel. The higher coumestrol flux through excised porcine esophageal mucosa was detected from nanoemulsions composed by a fluid phospholipid (dioleylphosphocholine, DOPC) in comparison with that of a rigid one (distearoylphosphocholine, DSPC) in two mucosa conditions (intact and injured)...
July 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28680144/transplanted-adipose-derived-stem-cells-can-be-short-lived-yet-accelerate-healing-of-acid-burn-skin-wounds-a-multimodal-imaging-study
#12
Ghulam Muhammad, Jiadi Xu, Jeff W M Bulte, Anna Jablonska, Piotr Walczak, Miroslaw Janowski
The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured and without treatment options. Here, we have shown that transplantation of adipose-derived stem cells (ASCs) accelerates the process of acid burn wound-healing. Pre-conditioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit. While the wounds were ultimately healed in all mice, histological analysis revealed that, in non-transplanted animals, the number of hair follicles was reduced...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28672263/functionalizing-soy-protein-nano-aggregates-with-ph-shifting-and-mano-thermo-sonication
#13
Gulcin Yildiz, Juan Andrade, Nicki E Engeseth, Hao Feng
Plant protein-mediated nano-delivery systems have gained increasing attention in the food and pharmaceutical industries in recent years. Several physical and chemical methods for improving the functional properties of plant proteins with respect to the native forms have been proposed. This study presents a new approach, which combines pH-shifting and mano-thermo-sonication (MTS) to produce soy protein nano-aggregates with significantly improved functional properties. Soy-protein isolate (SPI) was treated with pH-shifting at pH 12 or in combination with MTS and high-pressure homogenization (HPH)...
June 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28668252/nanotechnology-as-a-potential-therapeutic-alternative-for-schistosomiasis
#14
REVIEW
Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Laís Fernanda Machado, Bruna Taciane da Silva Bortoleti, Claudia Stoeglehner Sahd, Alan Ferreira Chagas, João Paulo Assolini, Francisco José de Abreu Oliveira, Wander Rogério Pavanelli, Ivete Conchon-Costa, Idessania Nazareth Costa, Francine Nesello Melanda
Schistosomiasis is a neglected disease that affects millions of people worldwide, recognized as the most important human helminth infection in terms of morbidity and mortality. The treatment of choice presents low bioavailability and water solubility, in addition to the induction of parasite resistance. In this context, researchers have been conducting studies seeking to develop new drugs to ensure safety, quality, and efficacy against this parasitosis. In this scenario, nanotechnology arises including the drug delivery systems in nanoscale: nanoemulsions, liposomes and nanoparticles...
June 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28656942/formulation-characterisation-and-in-vitro-skin-diffusion-of-nanostructured-lipid-carriers-for-deoxyarbutin-compared-to-a-nanoemulsion-and-conventional-cream
#15
Rendra P Tofani, Yeyet C Sumirtapura, Sasanti T Darijanto
The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells. This study developed novel nanostructured lipid carriers (NLCs) for improved topical delivery of deoxyarbutin (dArb), leading to improved depigmenting efficacy. dArb is a hydrophobic substance, but it easily degrades in aqueous medium and is thermolabile...
July 20, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28655469/transcutaneous-immunization-with-a-novel-imiquimod-nanoemulsion-induces-superior-t-cell-responses-and-virus-protection
#16
Pamela Aranda Lopez, Mark Denny, Ann-Kathrin Hartmann, Astrid Alflen, Hans Christian Probst, Esther von Stebut, Stefan Tenzer, Hansjörg Schild, Michael Stassen, Peter Langguth, Markus P Radsak
BACKGROUND: Transcutaneous immunization (TCI) is a novel vaccination strategy utilizing the skin associated lymphatic tissue to induce immune responses. TCI using a cytotoxic T lymphocyte (CTL) epitope and the Toll-like receptor 7 (TLR7) agonist imiquimod mounts strong CTL responses by activation and maturation of skin-derived dendritic cells (DCs) and their migration to lymph nodes. However, TCI based on the commercial formulation Aldara only induces transient CTL responses that needs further improvement for the induction of durable therapeutic immune responses...
June 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28654749/a-general-route-for-nanoemulsion-synthesis-using-low-energy-methods-at-constant-temperature
#17
Ankur Gupta, Abu Zayed Md Badruddoza, Patrick S Doyle
The central dogma of nanoemulsion formation using low-energy methods at constant temperature-popularly known as the emulsion inversion point (EIP) method-is that to create O/W nanoemulsions, water should be added to a mixture of an oil and surfactant. Here, we demonstrate that the above order of mixing is not universal and a reverse order of mixing could be superior, depending on the choice of surfactant and liquid phases. We propose a more general methodology to make O/W as well as W/O nanoemulsions by studying the variation of droplet size with the surfactant hydrophilic-lypophilic balance for several model systems...
July 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#18
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28627455/gemcitabine-vitamin-e-conjugates-synthesis-characterization-entrapment-into-nanoemulsions-and-in-vitro-deamination-and-antitumor-activity
#19
Ahmed Abu-Fayyad, Sami Nazzal
Gemcitabine is the first line therapy for pancreatic cancer. It is, however, extensively metabolized to the inactive form by deamination enzymatic reaction. Conjugation of gemcitabine with fatty acids on its 4-amino group was found to protect it from deamination deactivation reaction. The objective of the present study was to test the in-vitro anticancer activity of gemcitabine conjugated to the γ-tocotrienol isomer of vitamin E against pancreatic tumor cells. This objective was based on reported studies in which it was demonstrated that free tocotrienol isomers of vitamin E can potentiate the anticancer activity of gemcitabine...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28622558/photodynamic-therapy-treatment-of-onychomycosis-with-aluminium-phthalocyanine-chloride-nanoemulsions-a-proof-of-concept-clinical-trial
#20
Luciano Ferreira Morgado, Ana Regina Franchi Trávolo, Luís Alexandre Muehlmann, Paulo Souza Narcizo, Rodrigo Barbosa Nunes, Pedro Alencar Gomes Pereira, Karen Rapp Py-Daniel, Cheng-Shi Jiang, Jinsong Gu, Ricardo Bentes Azevedo, João Paulo Figueiró Longo
The conventional treatment of onychomycosis, a common fungal infection, consists in the use of local and systemic drugs for 4-6 months. This long protocol is often ineffective due to patient compliance, and usually promotes important collateral effects such as liver and kidney failure. As the alternative, Photodynamic Therapy (PDT) has been used as a noninvasive alternative local treatment for onychomycosis due to the reduction of systemic side effects, fact indicates their use for patients undergoing other systemic treatments...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
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