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https://www.readbyqxmd.com/read/28216465/increased-intestinal-permeation-and-modulation-of-presystemic-metabolism-of-resveratrol-formulated-into-self-emulsifying-drug-delivery-systems
#1
G Mamadou, C Charrueau, J Dairou, N Limas Nzouzi, B Eto, G Ponchel
Despite various beneficial biological properties, resveratrol lacks therapeutic applications because of poor bioavailability due to variable absorption and extensive metabolism. The present study aims at evaluating the capability of self-emulsifying drug delivery systems (SEDDS) to enhance resveratrol permeation across rat intestine and to modulate its presystemic metabolism. For that purpose, semi-solid (SS) and liquid (L) SEDDS were prepared and dispersed in an aqueous buffer to produce nanoemulsions (NE)...
February 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28211300/wound-healing-effects-of-nanoemulsion-containing-clove-essential-oil
#2
Prawez Alam, Mohammad J Ansari, Md Khalid Anwer, Mohammad Raish, Yoonus K T Kamal, Faiyaz Shakeel
The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0...
May 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28208014/improved-antitumor-efficacy-of-hyaluronic-acid-complexed-paclitaxel-nanoemulsions-in-treating-non-small-cell-lung-cancer
#3
Joo-Eun Kim, Young-Joon Park
Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with water solubility less than 1 µg/mL, which restricts its therapeutic application. To overcome the problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of paclitaxel (PTX) nanoemulsions and hyaluronic acid (HA) to specifically target non-small cell lung cancer. HPNs were composed of DL-α-tocopheryl acetate, soybean oil, polysorbate 80, ferric chloride, and HA and fabricated by high-pressure homogenization...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28194646/nanoemulsion-thermoreversible-pluronic-f127-based-hydrogel-containing-hyptis-pectinata-lamiaceae-leaf-essential-oil-produced-a-lasting-anti-hyperalgesic-effect-in-chronic-noninflammatory-widespread-pain-in-mice
#4
Lucindo J Quintans-Júnior, Renan G Brito, Jullyana S S Quintans, Priscila L Santos, Zaine T Camargo, Péricles A Barreto, Maria F Arrigoni-Blank, Waldecy Lucca-Júnior, Luciana Scotti, Marcus T Scotti, Sandra J Kolker, Kathleen A Sluka
We evaluated if a nanostructured thermoreversible Pluronic F127-based hydrogel incorporated with Hyptis pectinata leaf essential oil (NE-EOH) produces a long-lasting anti-hyperalgesic effect on chronic muscle pain in an animal model. We induced chronic muscle pain by injecting the gastrocnemius with saline injections. Paw and muscle withdrawal thresholds and motor performance were evaluated after treatment and compared with morphine, diazepam, or vehicle. Naloxone and methysergide administration tested the involvement of opioid and serotonin receptors, respectively...
February 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28188607/enhanced-skin-permeation-of-glabridin-using-eutectic-mixture-based-nanoemulsion
#5
Chen Liu, Jin Hu, Hong Sui, Qipeng Zhao, Xia Zhang, Wenping Wang
This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by a shaking bottle method. The pseudoternary phase diagrams of the oil phase (drug-loaded eutectic mixture or IPM), the surfactant (Tween 80:glycerol = 2:1, w/w), and water were constructed using the aqueous titration method. The obtained glabridin nanoemulsions were characterized and compared on their particle sizes, in vitro and in vivo penetration performance on rat skin, and storage stability...
February 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28176896/paclitaxel-loaded-hyaluronan-solid-nanoemulsions-for-enhanced-treatment-efficacy-in-ovarian-cancer
#6
Joo-Eun Kim, Young-Joon Park
Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. PTX-HSNs were fabricated using high-pressure homogenization with a microfluidizer and were lyophilized with d-mannitol. Hyaluronan was coated on the outside of the PTX-HSN sphere. The mean size of the PTX-HSNs was maintained less than 100 nm, with a relatively narrow size distribution. The PTX loading content was 3 mg/mL, and encapsulation efficiency (EE) was close to 100%...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28165811/nanoemulsion-for-improving-solubility-and-permeability-of-vitex-agnus-castus-extract-formulation-and-in-vitro-evaluation-using-pampa-and-caco-2-approaches
#7
Vieri Piazzini, Elena Monteforte, Cristina Luceri, Elisabetta Bigagli, Anna Rita Bilia, Maria Camilla Bergonzi
The purpose of this study was to develop new formulation for an improved oral delivery of Vitex agnus-castus (VAC) extract. After the optimization and validation of analytical method for quali-quantitative characterization of extract, nanoemulsion (NE) was selected as lipid-based nanocarrier. The composition of extract-loaded NE resulted in triacetin as oil phase, labrasol as surfactant, cremophor EL as co-surfactant and water. NE contains until 60 mg/mL of extract. It was characterized by DLS and TEM analyses and its droplets appear dark with an average diameter of 11...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28159662/anti-inflammatory-effect-of-geranium-nanoemulsion-macrophages-induced-with-soluble-protein-of-candida-albicans
#8
Janice Luehring Giongo, Rodrigo de Almeida Vaucher, Michele Sagrillo, Roberto Christ Vianna Santos, Marta M M F Duarte, Vírginia Cielo Rech, Leonardo Quintana Soares Lopes, Ivana Beatriz da Cruz, Etiane Tatsch, Rafael Noal Moresco, Patricia Gomes, Martin Steppe
Pelargonium graveolens is a member of the Geraniaceae family and has been used in folk medicine in many countries because of its anti-inflammatory activity. No studies have yet been reported to evaluate the anti-inflammatory activity of a nanoemulsion containing geranium oil (GO) model in macrophages. In this study the anti-inflammatory effect of Geranium nanoemulsion (NEG) macrophages induced with soluble proteins of Candida albicans was investigated. GO presented citronellol (17.74%) and geraniol (14.43%) as main constituents...
January 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28152481/in-vivo-evaluation-of-a-self-nanoemulsifying-drug-delivery-system-for-curcumin
#9
R Nazari-Vanani, L Moezi, H Heli
Curcumin has attracted particular attention in recent years due to its great variety of beneficial biological and pharmacological activities. However, its efficacy has been limited due to its low bioavailability, and this limitation can be overcome by novel drug delivery systems. Self-nanoemulsifying drug delivery system (SNEDDS) is a novel route to improve oral bioavailability of lipophilic drugs. SNEDDS spontaneously forms fine oil-in-water nanoemulsion by mild agitation. An optimal formula for a SNEDDS comprised ethyl oleate:tween 80:PEG 600 (50:40:10% w/w) with 11...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28152462/a-novel-ionic-amphiphilic-chitosan-derivative-as-a-stabilizer-of-nanoemulsions-improvement-of-antimicrobial-activity-of-cymbopogon-citratus-essential-oil
#10
Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Donatella Usai, Ioannis Liakos, Alice Garzoni, Maura Fiamma, Stefania Zanetti, Athanassia Athanassiou, Carla Caramella, Franca Ferrari
Amphiphilic chitosans have been recently proposed to improve delivery of poorly soluble drugs. In the present paper a derivative obtained by ionic interaction between chitosan and oleic acid was for the first time studied to physically stabilize o/w nanoemulsions of an antimicrobial essential oil, Cymbopogon citratus (Lemongrass), in a low energy and mild conditions emulsification process. The novel combination of spontaneous emulsification process with chitosan oleate amphiphilic properties resulted in a stable dispersion of a few hundred nanometer droplets...
January 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28145556/a-new-method-for-the-formulation-of-double-nanoemulsions
#11
Shukai Ding, Nicolas Anton, Salman Akram, Meriem Er-Rafik, Halina Anton, Andrey Klymchenko, Wei Yu, Thierry F Vandamme, Christophe A Serra
Double emulsions are very attractive systems for many reasons; the most important of these are their capacity to encapsulate hydrophilic and lipophilic molecules simultaneously in a single particle and their potentiality to protect fragile hydrophilic molecules from the continuous phase. Double emulsions represent a technology that is widely present down to the micrometer scale; however, double nanoemulsions, with their new potential applications as nanomedicines or diagnosis agents, currently present a significant challenge...
February 1, 2017: Soft Matter
https://www.readbyqxmd.com/read/28142240/asymmetric-flasklike-hollow-carbonaceous-nanoparticles-fabricated-by-the-synergistic-interaction-between-soft-template-and-biomass
#12
Chunhong Chen, Haiyan Wang, Chuanlong Han, Jiang Deng, Jing Wang, Mingming Li, Minghui Tang, Haiyan Jin, Yong Wang
The soft template method is broadly applied to the fabrication of hollow-structured nanomaterials. However, due to the instability and the typical spherical shape of these soft templates, the resultant particles have a spherical morphology with a wide size distribution. Herein, we developed a sustainable route to fabricate asymmetric flasklike hollow carbonaceous structures with a highly uniform morphology and a narrow size distribution using the soft template method. A dynamic growth mechanism induced by the synergetic interactions between template and biomass is proposed...
February 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28126680/testing-of-bioactive-nanovesicles-on-hepatotoxicity-of-atypical-antipsychotics-via-digital-holography
#13
Fatma Ozturk Kirbay, Caner Geyik, Emine Guler, Ozan Yesiltepe, Zinar Pinar Gumus, Dilek Odaci Demirkol, Hakan Coskunol, Suna Timur
Atypical antipsychotic drugs induce hepatic toxicity. Thus, it is of importance to eliminate the side effects of these drugs. Herein we describe the preparation of nanoemulsions with a dietary supplement; wheat germ oil (WGO), to ameliorate the liver damage induced by clozapine and olanzapine. THLE-2 cell line was used as a model to investigate the effects of these nanoemulsions on cell viability as well as antioxidative efficiency after antipsychotic insult. In this context, a conventional cell culture method; MTT was used along with a novel cellular imaging technique called digital holography (DH) to evaluate cell viability...
January 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28126608/oil-in-microgel-strategy-for-enzymatic-triggered-release-of-hydrophobic-drugs
#14
C A Busatto, H Labie, V Lapeyre, R Auzely-Velty, A Perro, N Casis, J Luna, D A Estenoz, V Ravaine
Polymer microgels have received considerable attention due to their great potential in the biomedical field as drug delivery systems. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan composed of N-acetyl-d-glucosamine and d-glucuronic acid. This polymer is biodegradable, nontoxic, and can be chemically modified. In this work, a co-flow microfluidic strategy for the preparation of biodegradable HA microgels encapsulating hydrophobic drugs is presented. The approach relies on: (i) generation of a primary oil-in-water (O/W) nanoemulsion by the ultrasonication method, (ii) formation of a double oil-in-water-in-oil emulsion (O/W/O) using microfluidics, and (iii) cross-linking of microgels by photopolymerization of HA precursors modified with methacrylate groups (HA-MA) present in the aqueous phase of the droplets...
January 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28126457/properties-of-active-gelatin-films-incorporated-with-rutin-loaded-nanoemulsions
#15
Ilyes Dammak, Rosemary Aparecida de Carvalho, Carmen Sílvia Fávaro Trindade, Rodrigo Vinicius Lourenço, Paulo José do Amaral Sobral
Physico-chemical, mechanical, barrier, release profiles and antioxidant properties of composite gelatin based-films incorporated with rutin-loaded oil-in-water nanoemulsion, at various concentrations (5, 10, 15, or 20% (based on the weight of the gelatin powder)) were studied. All the gelatin/rutin-loaded nanoemulsion films displayed higher tensile strength and higher elongation at break than the gelatin control film. The composite films did not show significant differences in thickness, color, brightness and transparency...
January 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28125342/edible-nanoemulsions-as-carriers-of-active-ingredients-a-review
#16
Laura Salvia-Trujillo, Robert C Soliva-Fortuny, M Alejandra Rojas-Graü, D Julian McClements, Olga Martín-Belloso
There has been growing interest in the use of edible nanoemulsions as delivery systems for lipophilic active substances, such as oil-soluble vitamins, antimicrobials, flavors, and nutraceuticals, because of their unique physicochemical properties. Oil-in-water nanoemulsions consist of oil droplets with diameters typically between approximately 30 and 200 nm that are dispersed within an aqueous medium. The small droplet size usually leads to an improvement in stability, gravitational separation, and aggregation...
January 11, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28112478/real-time-monitoring-of-nanoparticle-formation-by-fret-imaging
#17
Brenda L Sanchez-Gaytan, François Fay, Sjoerd Hak, Amr Alaarg, Zahi A Fayad, Carlos Pérez-Medina, Willem J M Mulder, Yiming Zhao
Understanding the formation process of nanoparticles is of the utmost importance to improve their design and production. This especially holds true for self-assembled nanoparticles whose formation processes have been largely overlooked. Herein, we present a new technology that integrates a microfluidic-based nanoparticle synthesis method and Förster resonance energy transfer (FRET) microscopy imaging to visualize nanoparticle self-assembly in real time. Applied to different nanoparticle systems, for example, nanoemulsions, drug-loaded block-copolymer micelles, and nanocrystal-core reconstituted high-density lipoproteins, we have shown the approach's unique ability to investigate key parameters affecting nanoparticle formation...
January 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28111519/statistical-analysis-of-optimal-ultrasound-emulsification-parameters-in-thistle-oil-nanoemulsions
#18
Małgorzata A Miastkowska, Marcin Banach, Jolanta Pulit-Prociak, Elżbieta S Sikora, Agata Głogowska, Michał Zielina
Thistle oil (INCI: Silybum marianum seed oil) is known as an anti-oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. The aim of this work was the preparation and characterization of nanoemulsions, based on thistle oil. The non-ionic surfactants polysorbate 80 (PEG-20 sorbitan monooleate), decyl glucoside, and a polyglyceryl-4 ester blend were applied to stabilize the nanosystems...
2017: Journal of Surfactants and Detergents
https://www.readbyqxmd.com/read/28103395/influence-of-lipid-content-in-a-corn-oil-preparation-on-the-bioaccessibility-of-%C3%AE-carotene-a-comparison-of-low-fat-and-high-fat-samples
#19
Ziyuan Xia, David Julian McClements, Hang Xiao
Some individuals with fat maldigestion have compromised digestive systems, which causes the incomplete hydrolyzation of ingested lipids within the gastrointestinal tract (GIT). We studied the influence of high-fat (20%) and low-fat (4%) contents on the bioaccessibility of a highly hydrophobic nutraceutical (β-carotene) through a simulated GIT model consisting of mouth, stomach, and small intestine phases. The low-fat and high-fat values were chosen to simulate low-fat and high-fat diets. The triglycerides in the low-fat system were fully digested, whereas those in the high-fat system were only partially digested, thereby mimicking the digestive systems of individuals who exhibit fat maldigestion...
January 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28103390/physicochemical-property-and-oxidative-stability-of-whey-protein-concentrate-multiple-nanoemulsion-containing-fish-oil
#20
Jae-Young Hwang, Ho-Kyung Ha, Mee-Ryung Lee, Jin Wook Kim, Hyun-Jin Kim, Won-Jae Lee
The objectives of this research were to produce whey protein concentrate (WPC) multiple nanoemulsion (MNE) and to study how whey protein concentration level and antioxidant type affected the physicochemical properties and oxidative stability of fish oil in MNE. The morphological and physicochemical characteristics of MNE were investigated by using transmission electron microscopy and particle size analyzer, respectively. The oxidative stability of fish oil in MNEs was assessed by measuring peroxide value (PV), p-anisidine value, and volatile compounds...
January 19, 2017: Journal of Food Science
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