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https://www.readbyqxmd.com/read/29164187/fluorous-photosensitizers-enhance-photodynamic-therapy-with-perfluorocarbon-nanoemulsions
#1
Rachael A Day, Daniel A Estabrook, Jessica K Logan, Ellen M Sletten
Photodynamic therapy (PDT) requires a photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and a photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT.
November 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29159224/data-on-iron-oxide-core-oil-in-water-nanoemulsions-for-atherosclerosis-imaging
#2
Geoffrey Prévot, Stéphane Mornet, Cyril Lorenzato, Tina Kauss, Laurent Adumeau, Alexandra Gaubert, Julie Baillet, Philippe Barthélémy, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
The data presented in this article are related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the synthesis and the characteristics of the Superparamagnetic Iron Oxide Nanoparticles (SPION) loaded inside nanoemulsions (NEs). Focus was set on obtaining SPION with narrow size distribution and close to superparamagnetic limit (20 nm) in order to reach a reasonable magnetic signal. Nanoparticles (NPs) of three different sizes were obtained (7, 11 and 18 nm) and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), diffuse reflectance infrared Fourier transform (DRIFT) and thermogravimetric analysis (TGA)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29159220/data-on-atherosclerosis-specific-antibody-conjugation-to-nanoemulsions
#3
Geoffrey Prévot, Martine Duonor-Cérutti, Mélusine Larivière, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Philippe Barthélémy, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29155053/alpha-tocopherol-loaded-chitosan-oleate-nanoemulsions-for-wound-healing-evaluation-on-cell-lines-and-ex-vivo-human-biopsies-and-stabilization-in-spray-dried-trojan-microparticles
#4
M C Bonferoni, F Riva, A Invernizzi, E Dellera, G Sandri, S Rossi, G Marrubini, G Bruni, B Vigani, C Caramella, F Ferrari
An amphiphilic chitosan salt, chitosan oleate (CS-OA), was previously proposed for the physical stabilization of lemongrass antimicrobial nanoemulsions (NE) through a mild spontaneous emulsification process. As both chitosan and oleic acid are described in the literature for their positive effects in wound healing, in the present study CS-OA has been proposed to encapsulate alpha tocopherol (αTph) in NEs aimed to skin wounds. A NE formulation was developed showing about 220 nm dimensions, 36% drug loading, and αTph concentration up to 1 mg/ml...
November 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29154195/drug-loaded-nanoemulsion-as-positive-control-is-an-alternative-to-dmso-solutions-for-in-vitro-evaluation-of-curcumin-delivery-to-mcf-7-cells
#5
Eduarda Schultze, Karine Coradini, Paula Dos Santos Chaves, Liziane Pereira da Silva, Julieti Buss, Silvia S Guterres, Tiago Collares, Ruy Carlos Ruver Beck, Adriana R Pohlmann, Fabiana Kömmling Seixas
BACKGROUND: In vitro evaluation of toxicity and/or efficacy of nanostructured drug delivery systems involves the uses of different controls, including positive and negative controls, as well as a solution or dispersion of the drug in water. One of the most frequently solvent used to dilute poorly water soluble drugs to in vitro tests are dimethylsulfoxide (DMSO). However, its different specific surface area and different diffusion coefficients could make the comparative effects difficult...
May 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29150967/drug-delivery-strategies-for-chemoprevention-of-uvb%C3%A2-induced-skin-cancer-a-review
#6
REVIEW
Arvind Bagde, Arindam Mondal, Mandip Singh
Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed towards improvements in terms of delivery modes, therapeutic agents and site-specificity of therapeutics delivery...
November 18, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29149027/baccharis-reticularia-dc-and-limonene-nanoemulsions-promising-larvicidal-agents-for-aedes-aegypti-diptera-culicidae-control
#7
Gisele da S Botas, Rodrigo A S Cruz, Fernanda B de Almeida, Jonatas L Duarte, Raquel S Araújo, Raimundo Nonato P Souto, Ricardo Ferreira, José Carlos T Carvalho, Marcelo G Santos, Leandro Rocha, Vera Lúcia P Pereira, Caio P Fernandes
Baccharis reticularia DC. is a plant species from the Asteraceae family that is endemic to Brazil. Despite the great importance of Baccharis genus, no study has been carried out regarding either the phytochemical composition of B. reticularia or the evaluation of its larvicidal potential. Considering the intrinsic immiscibility of essential oils, this study shows larvicidal nanoemulsions containing the B. reticularia phytochemically characterized essential oil and its main constituent against Aedes aegypti...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29141479/development-of-a-carboxymethyl-chitosan-functionalized-nanoemulsion-formulation-for-increasing-aqueous-solubility-stability-and-skin-permeability-of-astaxanthin-using-low-energy-method
#8
Liang Hong, Chuan-Li Zhou, Feng-Ping Chen, Dan Han, Chun-Yuan Wang, Jia-Xin Li, Zhe Chi, Chen-Guang Liu
In this research, firstly astaxanthin (ASX)-loaded nanoemulsions (NEs) were produced using a convenient low-energy emulsion phase inversion method. The optimised ASX-NEs were prepared in the presence of Cremophor(®) EL and Labrafil(®) M 1944 CS, with a surfactant-to-oil ratio of 4:6. The ASX-NE droplets were spherical with a mean droplet diameter below 100 nm and a small negative surface charge. The system was stable without alteration of mean droplet diameter for three months. Then, the ASX-NE was functionalised with carboxymethyl chitosan (CMCS) through direct CMCS (0...
November 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29139323/jaboticaba-plinia-peruviana-extract-nanoemulsions-development-stability-and-in-vitro-antioxidant-activity
#9
Letícia Mazzarino, Heloísa da Silva Pitz, Ana Paula Lorenzen Voytena, Adriana Carla Dias Trevisan, Rosa Maria Ribeiro-Do-Valle, Marcelo Maraschin
OBJECTIVE: The aim of this work is to develop and characterize nanoemulsions containing jaboticaba extract (Plinia peruviana) aiming pharmaceutical and cosmetic applications. METHODS: Nanoemulsions were prepared by high-pressure homogenization method using different concentrations of components (oil, surfactant, and extract) and homogenization pressures, in order to optimize the preparation conditions. Both unloaded and extract-loaded nanoemulsions were characterized according their size, polydispersity, zeta potential, pH, morphology, and physical stability...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29138563/squarticles-as-the-nanoantidotes-to-sequester-the-overdosed-antidepressant-for-detoxification
#10
Chun-Han Chen, Tse-Hung Huang, Ahmed O Elzoghby, Pei-Wen Wang, Chia-Wen Chang, Jia-You Fang
The increasing death rate caused by drug overdose points to an urgent demand for the development of novel detoxification therapy. In an attempt to detoxify tricyclic antidepressant overdose, we prepared a lipid nanoemulsion, called squarticles, as the nanoantidote. Squalene was the major lipid matrix of the squarticles. Here, we present the animal study to investigate both the pharmacokinetic and pharmacodynamic effects of squarticles on amitriptyline intoxication. The anionic and cationic squarticles had average diameters of 97 and 122 nm, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137746/ultrasonically-tailored-chemically-engineered-and-qbd-enabled-fabrication-of-agomelatine-nanoemulsion-optimization-characterization-ex-vivo-permeation-and-stability-study
#11
Shakeeb Ahmed, Azka Gull, Mahtab Alam, Mohd Aqil, Yasmin Sultana
The objective of present study was to develop a nanoemulsion formulation of agomelatine (BCS class II drug) for the solubility enhancement. Capmul MCM, Tween 80 and PEG-400 were selected as oil, surfactant and co-surfactant respectively. The high energy ultrasonication method was used for the preparation of nanoemulsion. Three-factor three-level central composite design was employed to get the best formulation. The independent variables selected for the optimization were % oil, %Smix and sonication time (second)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29126959/nanocarriers-as-phototherapeutic-drug-delivery-system-appraisal-of-three-different-nanosystems-in-an-in-vivo-and-in-vitro-exploratory-study
#12
Eduardo Ricci-Junior, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Félix Sancenón, Ramón Martínez-Máñez, João Alfredo de Moraes, Ralph Santos-Oliveira
The use of nanosystem as diagnosing and therapy systems is increasing each year. There are several nanosystems available nowadays and the most prominent ones are: mesoporous silica, nanoemulsion and polymeric nanoparticles due to its characteristics, like low toxicology, and easy-producing process. They all have advantages when compared with the traditional system used, since they show specific targeting, controlled release, and higher penetration. In this study were tested three different nanocarriers (polymeric nanoparticles, nanoemulsion and mesoporous silica) containing phthalocyanineas possible PDT drugs (nanodrugs)...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29122734/gene-editing-of-mps-i-human-fibroblasts-by-co-delivery-of-a-crispr-cas9-plasmid-and-a-donor-oligonucleotide-using-nanoemulsions-as-nonviral-carriers
#13
Roselena Silvestri Schuh, Talita Giacomet de Carvalho, Roberto Giugliani, Ursula Matte, Guilherme Baldo, Helder Ferreira Teixeira
Mucopolysaccharidosis type I (MPS I) is an inherited disease caused by the deficiency of alpha-L-iduronidase (IDUA). This study shows the use of nanoemulsions co-complexed with the plasmid of CRISPR/Cas9 system and a donor oligonucleotide aiming at MPS I gene editing in vitro. Nanoemulsions composed of MCT, DOPE, DOTAP, DSPE-PEG, and water were prepared by high-pressure homogenization. The DNA was complexed by adsorption or encapsulation of preformed DNA/DOTAP complexes with nanoemulsions at +4/ -1 charge ratio...
November 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29122674/antibiofilm-activity-of-nanoemulsions-of-cymbopogon-flexuosus-against-rapidly-growing-mycobacteria
#14
Grazielle Guidolin Rossi, Kevim Bordignon Guterres, Pauline Cordenonsi Bonez, Samanta da Silva Gundel, Vanessa Albertina Aggertt, Fallon Santos Siqueira, Aline Ferreira Ourique, Roger Wagnerd, Bruna Klein, Roberto Christ Vianna Santos, Marli Matiko Anraku de Campos
Rapidly growing mycobacteria (RGM) are opportunistic microorganisms that can cause both local and disseminated infections. When in biofilm, these pathogens become highly resistant to antimicrobials used in clinical practice. Composed abundantly of polymeric substances, biofilms delay the diffusion of antimicrobials, preventing the drug from penetrating the deeper layers and having an effective action. Therefore, the search for new and alternative therapeutic options has become of fundamental importance. Natural products fall into these options, especially essential oils...
November 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29118340/the-liquid-glass-jamming-transition-in-disordered-ionic-nanoemulsions
#15
Marco Braibanti, Ha Seong Kim, Nesrin Şenbil, Matthew J Pagenkopp, Thomas G Mason, Frank Scheffold
In quenched disordered out-of-equilibrium many-body colloidal systems, there are important distinctions between the glass transition, which is related to the onset of nonergodicity and loss of low-frequency relaxations caused by crowding, and the jamming transition, which is related to the dramatic increase in elasticity of the system caused by the deformation of constituent objects. For softer repulsive interaction potentials, these two transitions become increasingly smeared together, so measuring a clear distinction between where the glass ends and where jamming begins becomes very difficult or even impossible...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116538/environmentally-benign-nanometric-neem-laced-urea-emulsion-for-controlling-mosquito-population-in-environment
#16
Prabhakar Mishra, Merlyn Keziah Samuel, Ruchishya Reddy, Brij Kishore Tyagi, Amitava Mukherjee, Natarajan Chandrasekaran
The increasing risk of vector-borne diseases and the environmental pollution in the day-to-day life due to the usage of the conventional pesticides makes the role of nanotechnology to come into the action. The current study deals with one of the applications of nanotechnology through the formulation of neem urea nanoemulsion (NUNE). NUNE was formulated using neem oil, Tween 20, and urea using the microfluidization method. Prior to the development of nanoemulsion, the ratio of oil/surfactant/urea was optimized using the response surface modeling method...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29111904/optimization-and-characterization-of-the-formation-of-oil-in-water-diazinon-nanoemulsions-modeling-and-influence-of-the-oil-phase-surfactant-and-sonication
#17
Mohamed E I Badawy, Abdel-Fattah S A Saad, El-Sayed H M Tayeb, Sondos A Mohammed, Amany D Abd-Elnabi
Nanoemulsions are particularly suitable as a platform in the development of delivery systems for lipophilic functional agents. Current research describes the formation of oil-in-water (O/W) diazinon nanoemulsions using synthetic and natural additives by adopting a high-energy (ultrasound) emulsification method. The diazinon nanoemulsions were spontaneously formed by adding dropwise a mixture of diazinon, solvent and co-solvent in an aqueous solution containing a surfactant (tween or lecithin) with continuous stirring...
November 7, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29096550/optimization-of-nutraceutical-coenzyme-q10-nanoemulsion-with-improved-skin-permeability-and-anti-wrinkle-efficiency
#18
Eman S El-Leithy, Amna M Makky, Abeer M Khattab, Doaa G Hussein
Coenzyme Q10 (CoQ10) is an insoluble, poorly permeable antioxidant with great biological value which acts as anti-aging and anti-wrinkle agent. To improve its permeability through topical application, the current study aimed at formulating oil/water (o/w) nanoemulsion (NE) as an efficient vehicle for delivering (CoQ10) through the skin barriers. The solubility of (CoQ10) was tested for various oils, surfactants (S), and co-surfactants (CoS). The NE region was determined by constructing pseudoternary phase diagrams...
November 2, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29080846/safety-against-nephrotoxicity-in-paclitaxel-treatment-oral-nanocarrier-as-an-effective-tool-in-preclinical-evaluation-with-marked-in-vivo-antitumor-activity
#19
Hira Choudhury, Bapi Gorain, Rakesh Kumar Tekade, Manisha Pandey, Sanmoy Karmakar, Tapan Kumar Pal
Oral paclitaxel (PTXL) formulations freed from cremophor(®) EL (CrEL) is always in utmost demand by the cancerous patients due to toxicities associated with the currently marketed formulation. In our previous investigation [Int. J. Pharm. 2014; 460:131], we have developed an oral oil based nanocarrier for the lipophilic drug, PTXL to target bioavailability issue and patient compliance. Here, we report in vivo antitumor activity and 28-day sub-chronic toxicity of the developed PTXL nanoemulsion. It was observed that the apoptotic potential of oral PTXL nanoemulsion significantly inhibited the growth of solid tumor (59...
November 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29080506/encapsulation-of-carotenoids-extracted-from-halophilic-archaea-in-oil-in-water-o-w-micro-and-nano-emulsions
#20
Marwa Chaari, Ioanna Theochari, Vassiliki Papadimitriou, Aristotelis Xenakis, Emna Ammar
Carotenoids extracted from halophilc Archaea have potential health benefits. Their poor water-solubility and low bioavailability is a challenge to their incorporation into foods. The aim of this work was the carotenoids encapsulation into two oil-in-water (O/W) dispersions, to increase their use as functional food applications. A nanoemulsion produced by high pressure homogenization and a spontaneously formed microemulsion were conceived. The limonene was the dispersed oil phase, and mixtures of Triton X-100/Tween-80 (3:1) as emulsifiers and of water/glycerol (2:1) as the continuous aqueous phase...
October 16, 2017: Colloids and Surfaces. B, Biointerfaces
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