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https://www.readbyqxmd.com/read/28919754/preparation-of-coffee-oil-algae-oil-based-nanoemulsions-and-the-study-of-their-inhibition-effect-on-uva-induced-skin-damage-in-mice-and-melanoma-cell-growth
#1
Chu-Ching Yang, Chi-Feng Hung, Bing-Huei Chen
Coffee grounds, a waste by-product generated after making coffee, contains approximately 15% coffee oil which can be used as a raw material in cosmetics. Algae oil rich in docosahexaenoic acid (DHA) has been demonstrated to possess anticancer and anti-inflammation functions. The objectives of this study were to develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of fatty acids in coffee oil and algae oil and prepare a nanoemulsion for studying its inhibition effect on ultraviolet A-induced skin damage in mice and growth of melanoma cells B16-F10...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28917862/antibacterial-hydroxypropyl-methyl-cellulose-edible-films-containing-nanoemulsions-of-thymus-daenensis-essential-oil-for-food-packaging
#2
Roya Moghimi, Atousa Aliahmadi, Hasan Rafati
Edible films containing essential oils (EO) as natural antibacterial agents are promising systems for food preservation. In this work, nanoemulsions of Thymus daenensis EO (wild; F1 and cultivated; F2) were loaded in hydroxyl propyl methyl cellulose (HPMC) films and the effect of different parameters (polymer, plasticizer, and EO concentration) on the film properties were analyzed and optimized. Prepared HPMC films were characterized in terms of EO loading, morphology, mechanical properties, and the antibacterial activity...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917836/erythromycin-encapsulation-in-nanoemulsion-based-delivery-systems-for-treatment-of-helicobacter-pylori-infection-protection-and-synergy
#3
Le Tuyet Chau Tran, Claire Gueutin, Ghislaine Frebourg, Christophe Burucoa, Vincent Faivre
Poorly water-soluble and unstable compounds are difficult to develop as drug products using conventional formulation techniques. The aim of the present study was to develop and evaluate a nanoformulation prepared by a hot high-pressure homogenization method, which was a scalable and solvent-free process. We successfully prepared stable nanodispersions to protect a labile antibiotic, erythromycin. The mean diameter of the dispersed droplets was approximately 150 nm, and size distribution was unimodal. Dispersion was physically stable at room temperature for over six months...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917151/a-novel-self-nanoemulsifying-formulation-for-sunitinib-evaluation-of-anticancer-efficacy
#4
R Nazari-Vanani, N Azarpira, H Heli, K Karimian, N Sattarahmady
Breast cancer is the top cancer and a main cause of death among women. The incidence of this cancer is increasing in the world. Sunitinib maleate is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that inhibits tumor cell proliferation and angiogenesis, and has been administrated as an anticancer drug. Self-nanoemulsifying drug delivery system (SNEDDS) is an isotopic mixture of an oil, a surfactant and usually a co-surfactant, which can spontaneously form fine oil-in-water nanoemulsion in aqueous media...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914324/multiple-particle-tracking-study-of-thermally-gelling-nanoemulsions
#5
Li-Chiun Cheng, Lilian C Hsiao, Patrick S Doyle
We perform multiple particle tracking (MPT) on a thermally-gelling oil-in-water nanoemulsion system. Carboxylated and plain polystyrene probes are used to investigate the role of colloidal probe size and surface chemistry on MPT in the nanoemulsion system. As temperature increases, hydrophobic groups of PEG-based gelators (PEGDA) partition into the oil/water interface and bridge droplets. This intercolloidal attraction generates a wide variety of microstructures consisting of droplet-rich and droplet-poor phases...
September 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28911665/nanostructures-current-uses-and-future-applications-in-food-science
#6
REVIEW
Kavitha Pathakoti, Manjunath Manubolu, Huey-Min Hwang
Recent developments in nanoscience and nanotechnology intend novel and innovative applications in the food sector, which is rather recent compared with their use in biomedical and pharmaceutical applications. Nanostructured materials are having applications in various sectors of the food science comprising nanosensors, new packaging materials, and encapsulated food components. Nanostructured systems in food include polymeric nanoparticles, liposomes, nanoemulsions, and microemulsions. These materials enhance solubility, improve bioavailability, facilitate controlled release, and protect bioactive components during manufacture and storage...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28899764/iron-oxide-core-oil-in-water-nanoemulsion-as-tracer-for-atherosclerosis-mpi-and-mri-imaging
#7
Geoffrey Prévot, Tina Kauss, Cyril Lorenzato, Alexandra Gaubert, Mélusine Larivière, Julie Baillet, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Laurent Adumeau, Stéphane Mornet, Philippe Barthélémy, Martine Duonor-Cérutti, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
PURPOSE: For early atherosclerosis imaging, magnetic oil-in-water nanoemulsion (NE) decorated with atheroma specific monoclonal antibody was designed for Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI). MPI is an emerging technique based on direct mapping of superparamagnetic nanoparticles which may advantageously complement MRI. METHODS: NE oily droplets were loaded with superparamagnetic iron oxide nanoparticles of 7, 11 and 18nm and biofunctionalized with atheroma specific scFv-Fc TEG4-2C antibody...
September 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28895402/acetate-induced-disassembly-of-spherical-iron-oxide-nanoparticle-clusters-into-monodispersed-core-shell-structures-upon-nanoemulsion-fusion
#8
Ahmet Kertmen, Pau Torruella, Emerson Coy, Luis Yate, Grzegorz Nowaczyk, Jacek Gapiński, Carmen Vogt, Muhammet Sadaka Toprak, Sonia Estrade, Francesca Peiró, Slawomir Milewski, Stefan Jurga, Ryszard Andruszkiewicz
It has been long known that the physical encapsulation of the oleic acid capped iron oxide nanoparticles (OA-IONPs) with cetyltrimethylammonium (CTA+) surfactant induces the spherical iron oxide nanoparticle cluster (IONPC) formation. However, behavior and functional properties of IONPCs in chemical reactions have been largely neglected and still not well understood. Herein we report on an unconventional ligand exchange function of IONPCs activated when they are dispersed in an ethyl acetate/acetate buffer system...
September 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28892871/formulation-by-design-approach-for-development-of-ultrafine-self-nanoemulsifying-systems-of-rosuvastatin-calcium-containing-long-chain-lipophiles-for-hyperlipidemia-management
#9
Sarwar Beg, O P Katare, Bhupinder Singh
The present work entails systematic development of liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) of rosuvastatin calcium containing long-chain lipophiles using QbD-driven Formulation by Design (FbD) approach. Elements of quality target product profile (QTPP) were defined and critical material attributes (CQAs) earmarked. Excipient screening was performed for selecting a suitable long-chain lipophile along with a surfactant and a cosolvent. Maximal drug solubility was observed in Peceol (i.e., lipid), Tween 80 (i...
August 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28892789/thymoquinone-rich-fraction-nanoemulsion-tqrfne-decreases-a%C3%AE-40-and-a%C3%AE-42-levels-by-modulating-app-processing-up-regulating-ide-and-lrp1-and-down-regulating-bace1-and-rage-in-response-to-high-fat-cholesterol-diet-induced-rats
#10
Norsharina Ismail, Maznah Ismail, Nur Hanisah Azmi, Muhammad Firdaus Abu Bakar, Zhang Yida, Maizaton Atmadini Abdullah, Hamidon Basri
Though the causes of Alzheimer's disease (AD) are yet to be understood, much evidence has suggested that excessive amyloid-β (Aβ) accumulation due to abnormal amyloid-β precursor protein (APP) processing and Aβ metabolism are crucial processes towards AD pathogenesis. Hence, approaches aiming at APP processing and Aβ metabolism are currently being actively pursued for the management of AD. Studies suggest that high cholesterol and a high fat diet have harmful effects on cognitive function and may instigate the commencement of AD pathogenesis...
September 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28889028/development-and-in-vitro-in-vivo-performance-of-self-nanoemulsifying-drug-delivery-systems-loaded-with-candesartan-cilexetil
#11
Khaled AboulFotouh, Ayat A Allam, Mahmoud El-Badry, Ahmed M El-Sayed
Candesartan cilexetil is widely used in the management of hypertension and heart failure. The drug delivery encounters obstacles of poor aqueous solubility, efflux by intestinal P-glycoprotein and vulnerability to enzymatic degradation in small intestine. Self-nanoemulsifying drug delivery systems (SNEDDS) loaded with candesartan cilexetil were successfully developed to overcome such obstacles. Preliminary screening was carried out to select proper surfactant, co-surfactant and oil combination for successful SNEDDS formulation...
September 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28889001/decontamination-of-fresh-cut-cucumber-slices-by-a-combination-of-a-modified-chitosan-coating-containing-carvacrol-nanoemulsions-and-pulsed-light
#12
Özge Taştan, Gianpiero Pataro, Francesco Donsì, Giovanna Ferrari, Taner Baysal
In this study, the impact of the combination of pulsed light (PL) treatments with antimicrobial coatings, consisting of modified chitosan suspensions incorporating carvacrol nanoemulsions, was investigated on the decontamination of fresh-cut cucumber slices. The upper surface of the cucumber slices, with or without the coating deposition, was inoculated with Escherichia coli ATCC 26 to reach a final concentration of 10(7)CFU/g of the vegetable. PL treatments were conducted at different fluence (4, 8, and 12J/cm(2)) on the inoculated surface of cucumber slices...
August 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28881206/polyglycerolated-nanocarriers-with-increased-ligand-multivalency-for-enhanced-invivo-therapeutic-efficacy-of-paclitaxel
#13
Trang Huyen Le Kim, Jeong Heon Yu, Hwiseok Jun, Moon Young Yang, Mi-Jin Yang, Jae-Woo Cho, Jin Woong Kim, Jee Seon Kim, Yoon Sung Nam
Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence, a new structure of hydrophilic corona allowing a higher ligand density without loss of excellent biocompatibility is highly desirable. Here we introduce tumor-targeted polyglycerolated (PGylated) nanocarriers that dramatically enhance the in vivo therapeutic efficacy of incorporated paclitaxel simply by increasing the surface density of hydrophobic tumor-targeting ligands...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28875455/albumin-conjugated-lipid-based-multilayered-nanoemulsion-improves-drug-specificity-and-anti-inflammatory-potential-at-the-spinal-cord-injury-gsite-after-intravenous-administration
#14
Xiao-Gang Chen, Fu Hua, Shou-Guo Wang, Hong-Hui Tang
Albumin-conjugated multilayered nanoemulsion (albumin-MNE) of methyl prednisolone (MP) was developed to ensure the specificity of the drug at the spinal cord injury (SCI) site. MNE was prepared by emulsification followed by ionic deposition of oppositely charged polymer followed by albumin conjugation using N-hydroxysuccinimide. Prepared nanoemulsion was characterized for particle size, polydispersity index (PDI), zeta potential (Zp), pH, viscosity, and entrapment efficiency. It was further evaluated for shape and morphological analysis, in vitro release, cell viability, and in vivo efficacy against post SCI-like conditions in terms of behavioral assessment, histopathological evaluation, and immunoflorescence assay of the histological sections showing Bax-driven apoptosis...
September 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28875405/appraisal-of-transdermal-water-in-oil-nanoemulgel-of-selegiline-hcl-for-the-effective-management-of-parkinson-s-disease-pharmacodynamic-pharmacokinetic-and-biochemical-investigations
#15
Sonal Setya, Tushar Madaan, Mohammad Tariq, B K Razdan, Sushama Talegaonkar
In the present study, the potential of transdermal nanoemulsion gel of selegiline hydrochloride for the treatment of Parkinson's disease was investigated. Water-in-oil nanoemulsions were developed by comparing low- and high-energy methods and were subjected to thermodynamic stability tests, in vitro permeation, and characterization studies. In vitro studies indicated that components of nanoemulsion acted as permeation enhancers with highest flux of 3.531 ± 1.94 μg/cm(2)/h from nanoemulsion SB6 containing 0...
September 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28873701/encapsulation-of-omega-3-fatty-acids-in-nanoemulsions-and-microgels-impact-of-delivery-system-type-and-protein-addition-on-gastrointestinal-fate
#16
Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng, David Julian McClements
Carefully designed delivery systems are required to encapsulate and protect omega-3 fatty acids in commercial food and beverage products, but then release them at the required site-of-action within the human gastrointestinal tract (GIT). Previously, we showed that the oxidative stability of flaxseed oil (a plant-based source of omega-3 fatty acids) encapsulated in nanoemulsion droplets or calcium alginate microgels (hydrogel beads) was improved using caseinate as a natural antioxidant. In this study, the impact of caseinate on the digestion of flaxseed oil encapsulated in these delivery systems was investigated using a simulated GIT...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873673/colloidal-properties-of-sodium-caseinate-stabilized-nanoemulsions-prepared-by-a-combination-of-a-high-energy-homogenization-and-evaporative-ripening-methods
#17
J M Montes de Oca-Ávalos, R J Candal, M L Herrera
Nanoemulsions stabilized by sodium caseinate (NaCas) were prepared using a combination of a high-energy homogenization and evaporative ripening methods. The effects of protein concentration and sucrose addition on physical properties were analyzed by dynamic light scattering (DLS), Turbiscan analysis, confocal laser scanning microscopy (CLSM) and small angle X-ray scattering (SAXS). Droplets sizes were smaller (~100nm in diameter) than the ones obtained by other methods (200 to 2000nm in diameter). The stability behavior was also different...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28867749/nanoemulsion-a-suitable-nanodelivery-system-of-clove-oil-for-anesthetizing-nile-tilapia
#18
Kantaporn Kheawfu, Surachai Pikulkaew, Wasana Chaisri, Siriporn Okonogi
Clove oil ethanolic solution (CL-EtOH) have always been used for fish anesthesia. However, ethanol causes major side effect of fish hypersensivity. In this study, clove oil loaded nanoemulsion (CLN) was developed in order to enhance water miscibility of clove oil without using ethanol in the preparations. The obtained CLN was characterized in terms of droplet size, size distribution expressed as polydispersity index (PDI), and zeta potential. The anesthetic effect of CLN in comparison with CL-EtOH on Oreochromis niloticus (Nile tilapia) was investigated...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28866224/highlights-in-nanocarriers-for-the-treatment-against-cervical-cancer
#19
REVIEW
Kaila P Medina-Alarcón, Aline R Voltan, Bruno Fonseca-Santos, Isabela Jacob Moro, Felipe de Oliveira Souza, Marlus Chorilli, Christiane Pienna Soares, André Gonzaga Dos Santos, Maria J S Mendes-Giannini, Ana M Fusco-Almeida
Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs)...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28860748/formulation-development-and-optimization-of-a-novel-octyldodecanol-based-nanoemulsion-for-transdermal-delivery-of-ceramide-iiib
#20
Runping Su, Li Yang, Yue Wang, Shanshan Yu, Yu Guo, Jiayu Deng, Qianqian Zhao, Xiangqun Jin
This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design...
2017: International Journal of Nanomedicine
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