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https://www.readbyqxmd.com/read/28532082/ultrasonic-nanotherapy-of-breast-cancer-using-novel-ultrasound-responsive-alginate-shelled-perfluorohexane-nanodroplets-in-vitro-and-in-vivo-evaluation
#1
Fatemeh Baghbani, Mahdieh Chegeni, Fathollah Moztarzadeh, Jamshid Aghazadeh Mohandesi, Manijhe Mokhtari-Dizaji
Development of a new class of multifunctional ultrasound-responsive smart nanocarriers that combine therapeutic properties with diagnostic imaging has gained great attention in recent years. Here, we describe the results of ultrasonic nanotherapy of breast cancer using novel alginate-stabilized perfluorohexane nanodroplets. Doxorubicin (Dox)-loaded multifunctional nanodroplets (Dox-NDs) were synthesized via nanoemulsion process and evaluated in vitro and in vivo with focus on cytotoxicity, hemolytic activity, biodistribution, biosafety, and antitumor activity...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532009/exploring-recent-developments-to-improve-antioxidant-anti-inflammatory-and-antimicrobial-efficacy-of-curcumin-a-review-of-new-trends-and-future-perspectives
#2
REVIEW
Zahid Hussain, Hnin Ei Thu, Muhammad Wahab Amjad, Fahad Hussain, Tarek A Ahmed, Shahzeb Khan
Curcumin derivatives have been well-documented due to their natural antioxidant, antimicrobial and anti-inflammatory activities. Curcuminoids have also gained widespread recognition due to their wide range of other activities which include anti-infective, anti-mutagenic, anticancer, anti-coagulant, antiarthrititc, and wound healing potential. Despite of having a wide range of activities, the inherent physicochemical characteristics (poor water solubility, low bioavailability, chemical instability, photodegradation, rapid metabolism and short half-life) of curcumin derivatives limit their pharmaceutical significance...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529070/parameters-influencing-the-course-of-passive-drug-loading-into-lipid-nanoemulsions
#3
Katrin Göke, Heike Bunjes
Passive drug loading can be used to effectively identify suitable colloidal lipid carrier systems for poorly water-soluble drugs. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles. Until now, the passive loading mechanism is unknown, which complicates reliable routine use. In this work, the influence of drug characteristics on the course of passive loading was investigated systematically varying drug surface area and drug solubility...
May 18, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28521752/synthesis-characterization-and-biological-verification-of-anti-her2-indocyanine-green-doxorubicin-loaded-polyethyleneimine-coated-perfluorocarbon-double-nanoemulsions-for-targeted-photochemotherapy-of-breast-cancer-cells
#4
Yu-Hsiang Lee, Yun-Ting Ma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer...
May 18, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28516478/determination-of-oral-bioavailability-of-curcuminoid-dispersions-and-nanoemulsions-prepared-from-curcuma-longa-linnaeus
#5
P S Lu, B S Inbaraj, B H Chen
BACKGROUND: Curcuminoid from Curcuma longa Linnaeus has been demonstrated to be effective in anti-cancer and anti-inflammation. The objectives of this study were to prepare curcuminoid dispersion and nanoemulsion from C. longa and determine their oral bioavailability in rats. RESULTS: After curcuminoid extraction using 99.5% ethanol, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and curcumin were separated within 10 min by HPLC with an Eclipse XDB-C18 column and a gradient mobile phase of 0...
May 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28516400/sytematic-investigation-of-the-role-of-surfactant-composition-and-choice-of-oil-design-of-a-nanoemulsion-based-adjuvant-inducing-concomitant-humoral-and-cd4-t-cell-responses
#6
Signe Tandrup Schmidt, Malene Aaby Neustrup, Stine Harloff-Helleberg, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Dennis Christensen, Camilla Foged
PURPOSE: Induction of cell-mediated immune (CMI) responses is crucial for vaccine-mediated protection against difficult vaccine targets, e.g., Chlamydia trachomatis (Ct). Adjuvants are included in subunit vaccines to potentiate immune responses, but many marketed adjuvants stimulate predominantly humoral immune responses. Therefore, there is an unmet medical need for new adjuvants, which potentiate humoral and CMI responses. The purpose was to design an oil-in-water nanoemulsion adjuvant containing a synthetic CMI-inducing mycobacterial monomycoloyl glycerol (MMG) analogue to concomitantly induce humoral and CMI responses...
May 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28508377/emulsion-versus-nanoemulsion-how-much-is-the-formulative-shift-critical-for-a-cosmetic-product
#7
Umberto M Musazzi, Silvia Franzè, Paola Minghetti, Antonella Casiraghi
The use of nanoemulsions in cosmetic products has been enlarged in the last decades because of several formulative advantages (e.g., the improved self-life stability, better texture properties). In addition, nanoemulsions seemed to improve the penetration of active ingredients through the human skin, comparing to conventional emulsion. In this contest, the risk of a higher systemic exposure of consumer to active ingredients, due to the ability of nanoemulsion to enhance permeation, results a critical attribute that should be evaluated for assuring the consumer safety...
May 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28507786/application-of-hyperosmotic-nanoemulsions-in-wound-healing-partial-thickness-injury-model-in-swine
#8
Sean Connell, Jianming Li, Abigail Durkes, Lynetta Freeman
Objective: In this work, we introduce a novel hyperosmotic nanoemulsion (HNE) topical agent for use in wound healing. These topical emulsion complexes combine a lipophilic thymol nanoemulsion with a hyperosmotic saccharide matrix. This combination has been previously shown to possess synergistic antimicrobial activity against a host of common and drug-resistant pathogens in vitro. Approach: In this study, we present additional data to assess the safety and efficacy of these emulsions in a partial thickness injury model in swine...
May 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28504287/%C3%AE-oryzanol-nanoemulsions-produced-by-a-low-energy-emulsification-method-an-evaluation-of-process-parameters-and-physicochemical-stability
#9
Jinfeng Zhong, Xiong Liu, Yonghua Wang, Xiaoli Qin, Zeling Li
γ-Oryzanol is a natural antioxidant and nutraceutical compound, which makes it a good candidate for nutraceuticals, food supplements and pharmaceutical preparations. However, the incorporation of γ-oryzanol into aqueous formulations is rather difficult and its bioavailability can be severely decreased because of its water-insoluble property. In this study, γ-oryzanol-enriched nanoemulsion based fish oil and medium-chain triglyceride as carrier oils were proposed. The main objective was to optimize process parameters to form stable nanoemulsions and evaluate their physicochemical stability...
May 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28503949/silymarin-nanoemulsion-against-human-hepatocellular-carcinoma-development-and-optimization
#10
Usama Ahmad, Juber Akhtar, Satya Prakash Singh, Farhan Jalees Ahmad, Sahabjada Siddiqui
OBJECTIVE: Nanoemulsion of silymarin was developed and optimized. MATERIALS AND METHODS: Nanoemulsion was made by aqueous titration method. Sefsol 218 (5.8% v/v), Kolliphor RH40 and polyethylene glycol 400 (Smix; 2:1; 28.99% v/v) were used as oil phase, surfactant and co-surfactant while distilled water (65.22% v/v) acted as an aqueous phase. Nanoemulsion was characterized on the basis of particle size, viscosity, electrical conductivity and refractive index. Further, in vitro release, in vivo pharmacokinetic study, stability study and cancer cell line studies were also performed...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28502064/optimization-of-water-oil-surfactant-system-for-preparation-of-medium-chain-length-poly-3-hydroxyalkanoates-mcl-pha-incorporated-nanoparticles-via-nanoemulsion-templating-technique
#11
K A Ishak, M Suffian M Annuar, N Ahmad
Polymeric nanoparticles gain a widespread interest in food and pharmaceutical industries as delivery systems that encapsulate, protect, and release lipophilic compounds such as omega-3 fatty acids, fat-soluble vitamins, carotenoids, carvedilol, cyclosporine, and ketoprofen. In this study, medium-chain-length poly-3-hydroxyalkanoate (mcl-PHA)-incorporated nanoparticle was developed via facile organic solvent-free nanoemulsion templating technique. The water content (W/surfactant-to-oil (S/O)), S/O, and Cremophor EL-to-Span 80 (Cremo/Sp80) ratios were first optimized using response surface methodology (RSM) to obtain nanoemulsion template prior to incorporation of mcl-PHA...
May 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28500938/importance-of-crystallinity-of-anchoring-block-of-semi-solid-amphiphilic-triblock-copolymers-in-stabilization-of-silicone-nanoemulsions
#12
Trang Huyen Le Kim, Hwiseok Jun, Yoon Sung Nam
Polymer emulsifiers solidified at the interface between oil and water can provide exceptional dispersion stability to emulsions due to the formation of unique semi-solid interphase. Our recent works showed that the structural stability of paraffin-in-water emulsions highly depends on the oil wettability of hydrophobic block of methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-b-PCL). Here we investigate the effects of the crystallinity of hydrophobic block of triblock copolymer-based emulsifiers, PCLL-b-PEG-b-PCLL, on the colloidal properties of silicone oil-in-water nanoemulsions...
April 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28497330/development-of-nanoemulsion-from-vitex-negundo-l-essential-oil-and-their-efficacy-of-antioxidant-antimicrobial-and-larvicidal-activities-aedes-aegypti-l
#13
Sundararajan Balasubramani, Thamaraiselvi Rajendhiran, Anil Kumar Moola, Ranjitha Kumari Bollipo Diana
It is believed that nanoemulsions were emerged as a promising candidate to improve the qualities of natural essential oil towards antimicrobial and insecticidal applications. In the present study, we have focused on the encapsulation of Vitex negundo L. leaf essential oil using Polysorbate80 for its different biological activities including antioxidant, bactericidal and larvicidal activity against dengue fever vector Aedes aegypti L. Initially, the nanoemulsion was prepared by low energy method and droplet size of the formulated nanoemulsion was characterized by using Dynamic Light Scattering analysis...
May 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28496323/a-novel-nanoemulsion-based-method-to-produce-ultrasmall-water-dispersible-nanoparticles-from-chitosan-surface-modified-with-cell-penetrating-peptide-for-oral-delivery-of-proteins-and-peptides
#14
Ghullam Reza Barbari, Farid Abedin Dorkoosh, Mohsen Amini, Mohammad Sharifzadeh, Fateme Atyabi, Saeed Balalaie, Niyousha Rafiee Tehrani, Morteza Rafiee Tehrani
A simple and reproducible water-in-oil (W/O) nanoemulsion technique for making ultrasmall (<15 nm), monodispersed and water-dispersible nanoparticles (NPs) from chitosan (CS) is reported. The nano-sized (50 nm) water pools of the W/O nanoemulsion serve as "nano-containers and nano-reactors". The entrapped polymer chains of CS inside these "nano-reactors" are covalently cross-linked with the chains of polyethylene glycol (PEG), leading to rigidification and formation of NPs. These NPs possess excessive swelling properties in aqueous medium and preserve integrity in all pH ranges due to chemical cross-linking with PEG...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28495582/evaluation-of-lipid-stabilised-tripropionin-nanodroplets-as-a-delivery-route-for-combretastatin-a4
#15
Victoria Mico, Antonia Charalambous, Sally A Peyman, Radwa H Abou-Saleh, Alexander F Markham, P Louise Coletta, Stephen D Evans
Lipid-based nanoemulsions are a cheap and elegant route for improving the delivery of hydrophobic drugs. Easy and quick to prepare, nanoemulsions have promise for the delivery of different therapeutic agents. Although multiple studies have investigated the effects of the oil and preparation conditions on the size of the nanoemulsion nanodroplets for food applications, analogous studies for nanoemulsions for therapeutic applications are limited. Here we present a study on the production of lipid-stabilised oil nanodroplets (LONDs) towards medical applications...
May 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28490064/thymol-nanoemulsions-formed-via-spontaneous-emulsification-physical-and-antimicrobial-properties
#16
Jianming Li, Jun Won Chang, Megan Saenger, Amanda Deering
In this work, we prepared various sub-micron thymol emulsions with high hydrophilic-lipophilic balance (HLB) surfactants via spontaneous emulsification. Emulsion properties, such as size, polydispersity and charge, were assessed for each surfactant type and mass fraction. Emulsion stability was characterized by monitoring droplet size following exposure to physical (centrifugation) and thermal stressors (freeze, thaw cycling). Emulsions were subsequently screened against several challenge pathogens to evaluate antimicrobial efficacy...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28480833/nanoemulsion-for-the-effective-treatment-and-management-of-anti-tubercular-drug-therapy
#17
Sarwar Beg, Sumant Saini, Sarim Imam, Mahfoozur Rahman, Suryakanta Swain, M S Hasnain
BACKGROUND: Tuberculosis is considered as one of the deadliest diseases of human existence. Since ancient age the treatment of tuberculosis has been highly challenging primarily owing to the pathogenic nature of the Mycobacterium and its diverse spots of localization in human body including lungs, liver, spleen, eye, meninges and lymph nodes. METHODS: The conventional drug therapy employed for the treatment of tuberculosis is not highly satisfactorily owing to low oral bioavailability of the drugs...
May 3, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28479362/preparation-of-nanoemulsions-by-premix-membrane-emulsification-which-parameters-have-a-significant-influence-on-the-resulting-particle-size
#18
Sandra Gehrmann, Heike Bunjes
Oil-in-water emulsions with particle sizes smaller than 200 nm are interesting carrier systems for poorly water soluble drugs. Such emulsions can be produced by premix membrane emulsification. In this study, it was systematically investigated which process and formulation parameters have a strong influence on the resulting quality of a triglyceride emulsion. The influence of the pre-emulsion quality and the emulsifier concentration was examined. Also a design of experiments (DoE) approach was carried out: variables included were emulsifier (poloxamer 188, Tween 80, sucrose laurate), flow rate, cycle number and membrane material (polyester, nylon, cellulose acetate and aluminium oxide; pore sizes: 200 nm) and responses were d50-value and span for particle size and distribution width...
May 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28473656/efficient-intracellular-delivery-makes-cancer-cells-sensitive-to-nanoemulsive-chemodrugs
#19
Shan Liu, Dilong Chen, Yuming Yuan, Xue Zhang, Yao Li, Shenglei Yan, Jingqing Zhang
Evodiamine has been documented to possess activities in numerous cancer cells. Our preliminary study showed that A549 cells were insensitive to evodiamine. In this paper, A549 cells are sensitive to nanoemulsive evodiamine (EVONE) through an efficient intracellular and systematic delivery. EVONE entered tumor cells by energy-dependent and mainly through clathrin-mediated endocytosis. EVONE exerted a higher cytotoxicity in a dose- and time-dependent manner. The enhanced induction of cell cycle arrest was ascribed to the down-regulation of cyclin B and cyclin dependent kinase 1, while the enhanced induction of apoptosis was due to the activation of caspase -3, -8 and -9 and the decreased B-cell lymphoma 2/ assaciated X protein ratio...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472915/nanotechnology-a-promising-tool-towards-wound-healing
#20
Thaís Alberti, Daniela S Coelho, Ana Voytena, Heloísa Pitz, Manuel de Prá, Letícia Mazzarino, Shirley Kuhnen, Rosa Maria Ribeiro-do-Valle, Marcelo Maraschin, Beatriz Veleirinho
Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers have gained special attention in skin regeneration based on their structural similarity to the extracellular matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act as delivery systems for drugs, proteins, growth factors, and other molecules. Moreover, the morphology, biodegradability, and other functionalities of nanofibrous materials can be controlled towards specific conditions of wound healing...
May 3, 2017: Current Pharmaceutical Design
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