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https://www.readbyqxmd.com/read/28811530/evidence-for-ice-ocean-albedo-feedback-in-the-arctic-ocean-shifting-to-a-seasonal-ice-zone
#1
Haruhiko Kashiwase, Kay I Ohshima, Sohey Nihashi, Hajo Eicken
Ice-albedo feedback due to the albedo contrast between water and ice is a major factor in seasonal sea ice retreat, and has received increasing attention with the Arctic Ocean shifting to a seasonal ice cover. However, quantitative evaluation of such feedbacks is still insufficient. Here we provide quantitative evidence that heat input through the open water fraction is the primary driver of seasonal and interannual variations in Arctic sea ice retreat. Analyses of satellite data (1979-2014) and a simplified ice-upper ocean coupled model reveal that divergent ice motion in the early melt season triggers large-scale feedback which subsequently amplifies summer sea ice anomalies...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808470/non-surgical-retreatment-of-maxillary-lateral-incisor-with-unusual-anatomy-a-case-report-and-mini-review
#2
Ashraf Shubbar, Behnam Bolhari, Nooshin Fakhari, Parvin Alemi, Ali Nosrat
Knowledge about internal anatomy plays a crucial role in the success of the root canal treatment. Many studies on internal anatomy have repeatedly reported that maxillary lateral incisors have only one canal. The primary aim of this article was to describe successful non-surgical retreatment of a permanent maxillary lateral incisor with two root canals and open apices. The treatment was carried out using dental operating microscope and the canals were obturated with mineral trioxide aggregate (MTA) as an apical plug...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808459/evaluation-of-apically-extruded-debris-during-root-canal-retreatment-using-protaper-next-and-reciproc-in-severely-curved-canals
#3
Giselle Nevares, Kaline Romeiro, Diana Albuquerque, Felipe Xavier, Howard Fogel, Laila Freire, Rodrigo Cunha
INTRODUCTION: To compare the apical extrusion of debris produced during root obturating material removal from severely curved root canals using either Reciproc (REC) or ProTaper Next (PTN) systems. METHODS AND MATERIALS: Twenty-six mesial canals of lower molars were instrumented, filled and allocated into two groups (n=13). Micro-computed tomographic images were performed to determine the root canal configuration (Vertucci's type IV) and initial volume of obturation...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28804934/complicated-untreated-apical-periodontitis-causing-paraesthesia-a-case-report
#4
Domenico Ricucci, Simona Loghin, José F Siqueira
The purpose of this article was to report a case of untreated apical periodontitis resulting in severe late complications. A patient with an asymptomatic crowned root canal-treated mandibular molar revealing a radiographic substandard endodontic treatment and a slight periapical radiolucency was made aware of the treatment options and opted for no treatment. The lesion slightly increased in size after 6 years, but the tooth remained asymptomatic and endodontic retreatment was again refused. After 4 more years, the patient presented with an abscess and severe pain, complicated by paraesthesia of the left chin and lip...
August 14, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28804693/the-ability-of-reciproc-instruments-to-reach-full-working-length-without-glide-path-preparation-a-clinical-retrospective-study
#5
Andreas Bartols, Bernt-Peter Robra, Winfried Walther
BACKGROUND: Reciproc instruments are the only contemporary root canal instruments where glide path preparation is no longer strictly demanded by the manufacturer. As the complete preparation of root canals is associated with success in endodontic treatment we wanted to assess the ability and find predictors for Reciproc instruments to reach full working length (RFWL) in root canals of maxillary molars in primary root canal treatment (1°RCTx) and retreatment (2°RCTx) cases. METHODS: This retrospective study evaluated 255 endodontic treatment cases of maxillary molars...
2017: PeerJ
https://www.readbyqxmd.com/read/28802891/time-to-second-line-treatment-and-subsequent-relative-survival-in-older-patients-with-relapsed-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#6
Eric M Ammann, Tait D Shanafelt, Melissa C Larson, Kara B Wright, Bradley D McDowell, Brian K Link, Elizabeth A Chrischilles
BACKGROUND: Novel targeted therapies offer excellent short-term outcomes in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL). However, there is disagreement over how widely these therapies should be used in place of standard chemo-immunotherapy (CIT). We investigated whether stratification on the length of the interval between first-line (T1) and second-line (T2) treatments could identify a subgroup of older patients with relapsed CLL/SLL with an expectation of normal overall survival, and for whom CIT could be an acceptable treatment choice...
July 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28801967/retreatment-and-prolonged-therapy-with-subcutaneous-bortezomib-in-patients-with-relapsed-multiple-myeloma-a-randomized-controlled-phase-iii-study
#7
Evangelos Terpos, Marco Gobbi, Anna Potamianou, Marjolein Lahaye, Catherine Couturier, Michele Cavo
OBJECTIVES: This randomized, international, multicenter, open-label phase III study investigated the effects of experimental retreatment with subcutaneous bortezomib plus dexamethasone (VD) followed by prolonged bortezomib therapy vs. standard VD retreatment in patients with relapsed/refractory multiple myeloma. METHODS: Patients were randomized (2:1) to receive either experimental (n = 53) or standard (n = 27) retreatment, stratified by the number of prior therapy lines...
August 12, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28801510/therapeutic-options-for-bleeding-oesophageal-varices-cyanoacrylate-and-balloon-occluded-retrograde-obliteration-brto
#8
Helena L Frischtak, Jessica P Davis, Neeral L Shah
A 56-year-old male with cirrhosis presented with acute bleeding from cardiofundal gastroesophageal varices (GOV) and was treated with endoscopic cyanoacrylate glue. Glue therapy achieved stabilisation of the patient in the emergent setting. Three months later, the patient suffered rebleeding. At that time, he underwent retreatment with balloon-occluded retrograde obliteration (BRTO), with no recurrence at a follow-up of 14 months.Available treatments for bleeding GOV include methods to (a) directly obstruct the varices (endoscopic variceal ligation , sclerotherapy and cyanoacrylate glue, BRTO) or to (b) decrease portal pressure (surgical portacaval shunts; transportal intrahepatic portosystemic shunt)...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28798980/two-year-outcome-of-an-observe-and-plan-regimen-for-neovascular-age-related-macular-degeneration-treated-with-aflibercept
#9
Parmis Parvin, Marta Zola, Ali Dirani, Aude Ambresin, Irmela Mantel
PURPOSE: The purpose of our study was to investigate the two-year outcome of Aflibercept treatment for neovascular age-related macular degeneration (nAMD), using the Observe-and-Plan regimen, an individually planned treatment regimen, based on the predictability of an individual's need for retreatment, aiming to reduce the clinical burden. METHODS: Our prospective study used the Observe-and-Plan regimen with Aflibercept to treat nAMD: Three loading doses, followed by monthly observation visits until the disease-recurrence interval was determined, which then was shortened by 2 weeks in a treatment plan for the next three injections without intermediate monitoring visits...
August 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28798213/providing-experiential-business-and-management-training-for-biomedical-research-trainees
#10
Kimberly A Petrie, Robert H Carnahan, Abigail M Brown, Kathleen L Gould
Many biomedical PhD trainees lack exposure to business principles, which limits their competitiveness and effectiveness in academic and industry careers. To fill this training gap, we developed Business and Management Principles for Scientists, a semester-long program that combined didactic exposure to business fundamentals with practical team-based projects aimed at solving real business problems encountered by institutional shared--resource core facilities. The program also included a retreat featuring presentations by and networking with local life science entrepreneurs and final team presentations to expert judges...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28796346/fracture-of-nickel-titanium-rotary-instrument-during-root-canal-treatment-and-re-treatment-a-5-year-retrospective-study
#11
K Alfouzan, A Jamleh
AIM: To evaluate retrospectively the incidence of K3 nickel titanium rotary instrument fracture in referred cases during root canal treatment and re-treatment. METHODOLOGY: Clinical and radiographic reports of 12867 endodontic cases treated at the King Abdulaziz medical city between January 2010 and November 2015 were reviewed to obtain information on intra-canal fractured instruments with respect to the treatment performed, tooth type, and the size and at what level the instrument fractured (coronal, middle or apical)...
August 10, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28795488/angiographic-classification-of-patterns-of-restenosis-following-femoropopliteal-artery-intervention-a-proposed-scoring-system
#12
Lawrence A Garcia, Krishna J Rocha-Singh, Prakash Krishnan, Thomas Zeller, Gunnar Tepe, Mark Fleming, Juan F Granada, Mark A Turco, Christopher Tieché, Michael R Jaff
OBJECTIVES: To propose a classification system for characterizing angiographic femoropopliteal artery restenosis patterns associated with common endovascular modalities. BACKGROUND: Peripheral artery disease is a worldwide issue affecting millions of people. Despite a myriad of endovascular technologies available to treat peripheral artery disease of the femoropopliteal arteries, restenosis remains a common failure mode. Characterizing common patterns of restenosis is important to discern the potential impact of baseline patient, lesion, and procedural characteristics, as well as treatment modalities on either the primary success or the failure patterns associated with restenosis...
August 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28793376/genotype-mtbdrplus-assay-for-screening-and-characterization-of-isoniazid-and-rifampicin-resistance-associated-mutations-in-multidrug-resistant-mycobacterium-tuberculosis-from-india
#13
Sunil Sethi, Rakesh Yadav, Shreya Singh, Rajiv Khaneja, Ashutosh Aggarwal, Priyanka Agarwal, Digambar Behera
Multidrug resistant tuberculosis (MDR-TB) is rising and World health organization has recommended the line probe assay (LPA) for screening. In this study we assess LPA at a tertiary care center from North India in 1758 samples from suspected MDR-TB cases. All smear positive and/or M.tuberculosis culture confirmed cases (n=1170) were subjected to GenoType-MTBDR assay. Amongst these the majority were retreatment cases, smear positive at diagnosis (n=637). MDR prevalence of 7.8% was observed with the highest cases reported amongst MDR contacts (33...
August 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28792847/repeal-replace-repair-retreat-republicans-health-care-quagmire
#14
Jonathan Oberlander
For 7 years, Republicans vowed to repeal and replace the Affordable Care Act (ACA). With Donald Trump in the White House and Republican majorities in Congress, the GOP was poised to make good on that pledge. Yet less than 7 months into the Trump administration, the GOP’s crusade to dismantle..
August 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28790325/horizontal-mantle-flow-controls-subduction-dynamics
#15
E Ficini, L Dal Zilio, C Doglioni, T V Gerya
It is generally accepted that subduction is driven by downgoing-plate negative buoyancy. Yet plate age -the main control on buoyancy- exhibits little correlation with most of the present-day subduction velocities and slab dips. "West"-directed subduction zones are on average steeper (~65°) than "East"-directed (~27°). Also, a "westerly"-directed net rotation of the lithosphere relative to the mantle has been detected in the hotspot reference frame. Thus, the existence of an "easterly"-directed horizontal mantle wind could explain this subduction asymmetry, favouring steepening or lifting of slab dip angles...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783540/survival-of-melanoma-patients-treated-with-targeted-therapy-and-immunotherapy-after-systematic-upfront-control-of-brain-metastases-by-radiosurgery
#16
C Gaudy-Marqueste, A S Dussouil, R Carron, L Troin, N Malissen, A Loundou, S Monestier, S Mallet, M A Richard, J M Régis, J J Grob
BACKGROUND: Targeted therapy (TT) and immunotherapies (ITs) have dramatically improved survival in metastatic melanoma (MM). However, their efficacy on brain metastasis (BM) remains limited and poorly documented. PATIENTS AND METHODS: Retrospective cohort of consecutive MM patients (pts) with BMs, all systematically upfront treated by Gamma-Knife (GK) at first BM and retreated in case of new BMs, from 2010 to 2015 at the time when ipilimumab BRAF ± MEK inhibitors and anti-PD1 were introduced in practice...
August 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28782333/performance-of-self-reported-hiv-status-in-determining-true-hiv-status-among-older-adults-in-rural-south-africa-a-validation-study
#17
Julia K Rohr, F Xavier Gómez-Olivé, Molly Rosenberg, Jennifer Manne-Goehler, Pascal Geldsetzer, Ryan G Wagner, Brian Houle, Joshua A Salomon, Kathleen Kahn, Stephen Tollman, Lisa Berkman, Till Bärnighausen
INTRODUCTION: In South Africa, older adults make up a growing proportion of people living with HIV. HIV programmes are likely to reach older South Africans in home-based interventions where testing is not always feasible. We evaluate the accuracy of self-reported HIV status, which may provide useful information for targeting interventions or offer an alternative to biomarker testing. METHODS: Data were taken from the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI) baseline survey, which was conducted in rural Mpumalanga province, South Africa...
July 18, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28776870/marine-terminating-glaciers-sustain-high-productivity-in-greenland-fjords
#18
Lorenz Meire, John Mortensen, Patrick Meire, Thomas Juul-Pedersen, Mikael K Sejr, Søren Rysgaard, Rasmus Nygaard, Philippe Huybrechts, Filip J R Meysman
Accelerated mass loss from the Greenland ice sheet leads to glacier retreat and an increasing input of glacial meltwater to the fjords and coastal waters around Greenland. These high latitude ecosystems are highly productive and sustain important fisheries, yet it remains uncertain how they will respond to future changes in the Arctic cryosphere. Here we show that marine-terminating glaciers play a crucial role in sustaining high productivity of the fjord ecosystems. Hydrographic and biogeochemical data from two fjord systems adjacent to the Greenland ice sheet, suggest that marine ecosystem productivity is very differently regulated in fjords influenced by either land-terminating or marine-terminating glaciers...
August 4, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28776654/the-latency-complex-the-dead-hand-of-anti-development
#19
Barry D Proner
It is common knowledge that the same phenomena can be viewed in a variety of ways. This paper considers the implications of a constellation observed in some adult patients who have increasingly reminded the author of some of the children of latency age with whom he has also worked. In the literature these patients may also have been thought about in terms of 'defences of the self' (Fordham), patients who are 'difficult to reach' (Joseph), 'psychic retreats' (Steiner), and those who make 'attacks on linking' (Bion)...
September 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28771971/do-we-need-a-new-ct-scan-for-retreatment-of-intracranial-srs-patients
#20
David Wiant, Matthew Manning, Kyle Koch, Jacqueline Maurer, Lane Hayes, Han Liu, Qingyang Shang, Benjamin Sintay
PURPOSE: To determine if the treatment planning computed tomography scan (CT) from an initial intracranial stereotactic radiosurgery (SRS) treatment can be used for repeat courses of SRS. METHODS AND MATERIALS: Twenty-five patients with 40 brain metastases that received multiple courses of SRS were retrospectively studied. Magnetic resonance scans from repeat SRS (rMR) courses were registered to CT scans from the initial SRS (iCT) and repeat SRS (rCT). The CT scans were then registered to find the displacement of the rMR between iCT and rCT registrations...
August 3, 2017: Journal of Applied Clinical Medical Physics
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