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https://www.readbyqxmd.com/read/28108425/increased-age-associated-with-reduced-likelihood-of-recurrence-after-coiling-of-ruptured-aneurysms
#1
Lorenzo Rinaldo, Giuseppe Lanzino
OBJECTIVE: The effect of patient age on the likelihood of recurrence of ruptured aneurysms after endovascular coil embolization is not well understood. Our aim was to compare the incidence of aneurysmal recurrence after coiling between young and old patients. METHODS: We performed a retrospective cohort study on patients presenting to our institution with a ruptured intracranial aneurysm treated with endovascular coiling. Aneurysm recurrence was defined as a Modified Raymond Roy Classification (MRRC) grade of 3A or 3B on follow-up angiography performed on first follow-up angiography...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28107778/parabolic-variation-in-sexual-selection-intensity-across-the-range-of-a%C3%A2-cold-water-pipefish-implications-for-susceptibility-to-climate-change
#2
Nuno Monteiro, Mário Cunha, Lídia Ferreira, Natividade Vieira, Agostinho Antunes, David Lyons, Adam G Jones
While an understanding of evolutionary processes in shifting environments is vital in the context of rapid ecological change, one of the most potent selective forces, sexual selection, remains curiously unexplored. Variation in sexual selection across a species range, especially across a gradient of temperature regimes, has the potential to provide a window into the possible impacts of climate change on the evolution of mating patterns. Here, we investigated some of the links between temperature and indicators of sexual selection, using a cold-water pipefish as model...
January 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28107325/quality-of-life-and-resilience-exploring-a-fly-fishing-intervention-for-breast-cancer-survivors%C3%A2
#3
Barbara J Henry
BACKGROUND: The Casting for Recovery® therapeutic intervention provides a positive, nontraditional weekend experience for breast cancer survivors. Participants receive fly fishing instruction and participate in structured and unstructured therapeutic activities.
. OBJECTIVES: The aim of this study was to evaluate whether breast cancer survivors had improved resilience and quality-of-life scores after program participation.
. METHODS: Participants completed the Quality of Life Breast Cancer questionnaire and Connor-
Davidson Resilience Scale two weeks before and three and six months after the retreats...
February 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28106651/evaluating-the-impact-of-intraoperative-surgical-team-handoffs-on-patient-outcomes
#4
Lauren E Giugale, Sarah Sears, Erin S Lavelle, Charelle M Carter-Brooks, Michael Bonidie, Jonathan P Shepherd
OBJECTIVE: The aim of the study was to assess the impact of intraoperative personnel handoffs on clinical outcomes in patients undergoing minimally invasive sacrocolpopexy (SCP). METHODS: We retrospectively reviewed SCPs performed at an academic center between 2009 and 2014. We analyzed the number of staff handoffs, defined as any instance a scrub technician (tech) or circulating nurse handed off responsibility for a break or shift change. Outcomes included operative (OR) time and composite variables for major complications (conversion to an open procedure, bladder injury, bowel injury, blood transfusion, infection, ileus, bowel obstruction, readmission, or mesh complication) and prolapse recurrence (prolapse at or beyond the hymen or retreatment)...
January 18, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28105497/comparison-of-traditional-and-emerging-surgical-therapies-for-lower-urinary-tract-symptoms-in-men-a-review
#5
Christopher Smith, Paul Craig, Shayandokht Taleb, Shamar Young, Jafar Golzarian
Lower urinary tract symptoms (LUTS) are one of the most common health issues in men and pose a significant economic challenge in healthcare. Transurethral resection of the prostate (TURP) remains the gold standard surgical treatment for medically refractive LUTS secondary to benign prostatic hyperplasia. The institution of medical therapy and the development of several minimally invasive surgical therapies (MISTs) began in the 1980's and 1990's. Together, these therapies brought about a change in the natural course of the disease, stimulating investigation into the economic consequences of various management approaches...
January 19, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28105082/genetic-diagnosis-and-treatment-of-a-chinese-ketosis-prone-mody-3-family-with-depression
#6
Jun Tang, Chen-Yi Tang, Fang Wang, Yue Guo, Hao-Neng Tang, Ci-La Zhou, Shu-Wen Tan, Shi-Ping Liu, Zhi-Guang Zhou, Hou-De Zhou
BACKGROUND: To analyze the gene mutation and mental disorder of a Chinese ketosis-prone diabetes (KPD) family, and to make a precise diagnosis and give a treatment for them. METHODS: We studied a Chinese family with a clinical diagnosis of maturity-onset diabetes of the young (MODY). The clinical data and the blood samples were collected. The promotor and coding regions inclusive intron exon boundaries of the HNF1A, HNF4A were detected by polymerase chain reaction (PCR) and direct sequencing...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28100444/successful-retreatment-of-a-patient-with-chronic-hepatitis-c-genotype-2k-1b-virus-with-ombitasvir-paritaprevir-ritonavir-plus-dasabuvir
#7
Daniel Todt, Bernhard Schlevogt, Katja Deterding, Adam Grundhoff, Michael P Manns, Heiner Wedemeyer, Nicole Fischer, Markus Cornberg, Eike Steinmann
No abstract text is available yet for this article.
January 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28094039/cisplatin-can-be-safely-administered-to-ovarian-cancer-patients-with-hypersensitivity-to-carboplatin
#8
A Bergamini, C Pisano, M Di Napoli, L Arenare, C Della Pepa, R Tambaro, G Facchini, P Gargiulo, S Rossetti, G Mangili, S Pignata, S C Cecere
OBJECTIVE: Hypersensitivity reactions (HSR) are frequently reported in patients rechallenged with carboplatin for recurrent ovarian cancer (ROC) and represent a critical issue, since discontinuation of the platinum-based therapy could affect prognosis. Several strategies to allow platinum rechallenge have been described, with controversial outcomes. The aim of this study is to illustrate a 10-year experience with cisplatin in patients with a previous HSR to carboplatin or at risk for allergy...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28093082/less-extrusion-debris-during-the-retreatment-of-curved-canals-using-twisted-files-with-higher-rotational-speeds-an-ex-vivo-study
#9
Mengdong Liu, Shijiang Xiong, Fei Tan, Yi Liu
BACKGROUND: Debris extrusion from the apical foramen can be problematic in severely curved canals. This study aimed to assess the use of Twisted Files (TF) at different rotational speeds during retreatment, compared with manual technique using Triple-Flex Files (TFF). METHODS: Forty-eight mesiobuccal root canals were randomized to four groups (n = 12 per group). In groups A, B, and C, gutta-percha was removed using TF at 500, 1000, and 1500 rpm, respectively, while it was removed using TFF in group D...
January 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28089978/rituximab-retreatment-in-rheumatoid-arthritis-in-a-real-life-cohort-data-from-the-cererra-collaboration
#10
Katerina Chatzidionysiou, Elisabeth Lie, Galina Lukina, Merete L Hetland, Ellen-Margrethe Hauge, Karel Pavelka, Cem Gabay, Almut Scherer, Dan Nordström, Helena Canhao, Maria José Santos, Matija Tomsic, Ziga Rotar, M Victoria Hernández, Juan Gomez-Reino, Ioan Ancuta, Tore K Kvien, Ronald van Vollenhoven
OBJECTIVE: Several aspects of rituximab (RTX) retreatment in rheumatoid arthritis (RA) need to be further elucidated. The aim of this study was to describe the effect of repeated courses of RTX on disease activity and to compare 2 retreatment strategies, fixed-interval versus on-flare retreatment, in a large international, observational, collaborative study. METHODS: In the first analysis, patients with RA who received at least 4 cycles with RTX were included. In the second analysis, patients who received at least 1 RTX retreatment and for whom information about the strategy for retreatment was available were identified...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089197/long-term-follow-up-analysis-of-microsurgical-clip-ligation-and-endovascular-coil-embolization-for-dorsal-wall-blister-aneurysms-of-the-internal-carotid-artery
#11
Mason A Brown, Cristian F Guandique, Jonathan Parish, Aubrey C McMillan, Stephen Lehnert, Nassir Mansour, Michael Tu, Bradley N Bohnstedt, Troy D Payner, Thomas J Leipzig, Andrew J DeNardo, John A Scott, Aaron A Cohen-Gadol
: Blister aneurysms at non-branching sites of the dorsal internal carotid artery (dICA) are fragile, rare, and often difficult to treat. The purpose of this study is to address the demographics, treatment modalities, and long-term outcome of patients treated for dICA blister aneurysms. A retrospective review of medical records identified all consecutive patients who presented with a blister aneurysm from 2002 to 2011 at our institution. Eighteen patients (M=7, F=11; mean age: 48.4±15...
January 11, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28086753/better-care-provided-to-patients-with-tuberculosis-at-county-designated-tb-hospitals-ctd-compared-to-non-ctds-in-rural-china
#12
Li Yuan, Hui Zhang, Changming Zhou, Weili Jiang, Qi Zhao, Xu Biao
BACKGROUND: The primary unit of tuberculosis (TB) medical care in China is the county TB dispensary or county designated hospital (CTD), where patients can receive free diagnosis and treatment. However, a substantial number of patients seek their anti-TB treatment from general health facilities (Non-CTDs). This study aimed to investigate the first anti-TB treatment experience and choice of health facilities of retreated TB patients and their determinants. METHODS: A cross-sectional study was conducted in Jiangsu, Shandong and Sichuan provinces...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28081273/assessing-the-impact-of-retreat-mechanisms-in-a-simple-antarctic-ice-sheet-model-using-bayesian-calibration
#13
Kelsey L Ruckert, Gary Shaffer, David Pollard, Yawen Guan, Tony E Wong, Chris E Forest, Klaus Keller
The response of the Antarctic ice sheet (AIS) to changing climate forcings is an important driver of sea-level changes. Anthropogenic climate change may drive a sizeable AIS tipping point response with subsequent increases in coastal flooding risks. Many studies analyzing flood risks use simple models to project the future responses of AIS and its sea-level contributions. These analyses have provided important new insights, but they are often silent on the effects of potentially important processes such as Marine Ice Sheet Instability (MISI) or Marine Ice Cliff Instability (MICI)...
2017: PloS One
https://www.readbyqxmd.com/read/28079269/ledipasvir-plus-sofosbuvir-as-salvage-therapy-for-hcv-genotype-1-failures-to-prior-ns5a-inhibitors-regimens
#14
Norio Akuta, Hitomi Sezaki, Fumitaka Suzuki, Shunichiro Fujiyama, Yusuke Kawamura, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
There is little information on retreatment efficacy and predictors of the combination of ledipasvir and sofosbuvir (ledipasvir/sofosbuvir) for patients who fail to respond to NS5A inhibitors. NS5A resistance variants are known to persist for long periods after such treatment. Here, we evaluated 54 patients with chronic HCV genotype 1b infection, free of decompensated cirrhosis and hepatocellular carcinoma, for sustained virological response after 12 weeks (SVR12) of once-daily treatment with 90 mg ledipasvir and 400 mg sofosbuvir...
January 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28068907/hospitalized-care-for-mdr-tb-in-port-harcourt-nigeria-a-qualitative-study
#15
Kingsley Lezor Bieh, Ralf Weigel, Helen Smith
BACKGROUND: In Nigeria multidrug-resistant tuberculosis (MDR-TB) is prevalent in 2.9% of new TB cases and 14% of retreatment cases, and the country is one of 27 with high disease burden globally. Patients are admitted and confined to one of ten MDR-TB treatment facilities throughout the initial 8 months of treatment. The perspectives of MDR-TB patients shared on social media and in academic research and those of providers are limited to experiences of home-based care. In this study we explored the views of hospitalised MDR-TB patients and providers in one treatment facility in Nigeria, and describe how their experiences are linked to accessibility of care and support services, in line with international goals...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28068597/hpv-based-strategy-in-follow-up-of-patients-treated-for-high-grade-cervical-intra-epithelial-neoplasia-5-year-results-in-a-public-health-surveillance-setting
#16
P Garutti, C Borghi, C Bedoni, G Bonaccorsi, P Greco, M Tognon, F Martini
OBJECTIVE: Human papillomavirus (HPV) DNA testing is used increasingly for measuring the outcome of treatment for high-grade cervical intra-epithelial neoplasia (CIN2+). However, there is no international consensus regarding the number of tests and follow-up visits necessary in the post-treatment surveillance. A negative HPV DNA test result may permit relaxing the intensive post-treatment surveillance, but this possibility has not been standardized by all institutions to date. STUDY DESIGN: In 2008, the surveillance programme covering the Emilia-Romagna region in northern Italy adopted the HPV DNA test as a routine tool in the follow-up of women treated for CIN2+...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28068147/do-wellness-tourists-get-well-an-observational-study-of-multiple-dimensions-of-health-and-well-being-after-a-week-long-retreat
#17
Marc M Cohen, Fiona Elliott, Liza Oates, Adrian Schembri, Nitin Mantri
BACKGROUND: Wellness retreats use many complementary and alternative therapies within a holistic residential setting, yet few studies have evaluated the effect of retreat experiences on multiple dimensions of health and well-being, and no published studies have reported health outcomes in wellness tourists. OBJECTIVES: To assess the effect of a week-long wellness-retreat experience in wellness tourists. DESIGN: A longitudinal observational study with outcomes assessed upon arrival and departure and 6 weeks after the retreat...
January 9, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28064542/antibiotic-treatment-patterns-costs-and-resource-utilization-among-patients-with-community-acquired-pneumonia-a-us-cohort-study
#18
Christopher J Llop, Edward Tuttle, Glenn S Tillotson, Kerry LaPlante, Thomas M File
OBJECTIVES: The current treatment options for patients with community-acquired pneumonia (CAP) often present a trade-off between the potential for treatment failure and safety concerns. We set out to investigate real-world outcomes associated with the use of currently available antimicrobial treatment options for CAP in both the outpatient and inpatient (non-intensive care unit [ICU]) settings. METHODS: This claims-based retrospective study included adult patients diagnosed with CAP and treated with antibiotic therapies, including any oral fluoroquinolone, macrolide, or beta-lactam monotherapy in the outpatient setting, and intravenous (IV) levofloxacin or IV azithromycin/ceftriaxone in the inpatient setting...
January 18, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28063304/splenic-irradiation-for-splenomegaly-a-systematic-review
#19
REVIEW
Nicholas G Zaorsky, Graeme R Williams, Stefan K Barta, Nestor F Esnaola, Patricia L Kropf, Shelly B Hayes, Joshua E Meyer
Splenic irradiation (SI) is a palliative treatment option for symptomatic splenomegaly (i.e. for pain, early satiety, pancytopenia from sequestration) secondary to hematologic malignancies and disorders. The purpose of the current article is to review the literature on SI for hematologic malignancies and disorders, including: (1) patient selection and optimal technique; (2) efficacy of SI; and (3) toxicities of SI. PICOS/PRISMA methods are used to select 27 articles including 766 courses of SI for 486 patients from 1960 to 2016...
December 22, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28061839/risk-factors-for-mortality-in-tb-patients-a-10-year-electronic-record-review-in-a-south-african-province
#20
J Christo Heunis, N Gladys Kigozi, Perpetual Chikobvu, Sonja Botha, Hcj Dingie van Rensburg
BACKGROUND: Since 1990, reduction of tuberculosis (TB) mortality has been lower in South Africa than in other high-burden countries in Africa. This research investigated the influence of routinely captured demographic and clinical or programme variables on death in TB patients in the Free State Province. METHODS: A retrospective review of case information captured in the Electronic TB register (ETR.net) over the years 2003 to 2012 was conducted. Extracted data were subjected to descriptive and logistic regression analyses...
January 6, 2017: BMC Public Health
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