Eugénie Mutez, Lydie Larvor, Frédéric Leprêtre, Vincent Mouroux, Dorota Hamalek, Jean-Pierre Kerckaert, Jordi Pérez-Tur, Nawal Waucquier, Christel Vanbesien-Mailliot, Aurélie Duflot, David Devos, Luc Defebvre, Alexandre Kreisler, Bernard Frigard, Alain Destée, Marie-Christine Chartier-Harlin
To gain insight into systemic molecular events associated with an age-related neurodegenerative disorder, we compared gene expression patterns in peripheral blood mononuclear cells (PBMCs) sampled from elderly, healthy controls and from Parkinson's disease (PD) patients carrying the most frequently found mutation of the LRRK2 gene (G2019S). A transcriptomic approach enabled us to detect differentially expressed genes and revealed perturbations of pathways known to be involved in PD-related neurodegeneration: the ubiquitin-proteasome system, the mitochondrial oxidation system, inflammation, axonal guidance, calcium signalling and apoptosis...
October 2011: Neurobiology of Aging