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Fibromyalgia

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https://www.readbyqxmd.com/read/29457627/combination-pharmacotherapy-for-the-treatment-of-fibromyalgia-in-adults
#1
REVIEW
Joelle Thorpe, Bonnie Shum, R Andrew Moore, Philip J Wiffen, Ian Gilron
BACKGROUND: Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side effects. OBJECTIVES: To assess the efficacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, and Embase to September 2017...
February 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29456445/concurrent-validation-of-a-pressure-pain-threshold-scale-for-individuals-with-myofascial-pain-syndrome-and-fibromyalgia
#2
Scott W Cheatham, Morey J Kolber, G Monique Mokha, William J Hanney
Background: Manual pressure palpation is an examination technique used in the classification of myofascial pain syndrome (MPS) and fibromyalgia (FM). Currently, there are no validated systems for classifying results. A valid and reliable pressure pain threshold scale (PPTS) may provide a means for clinicians to grade, document, and report findings. The purpose of this investigation was to validate a PPTS in individuals diagnosed with MPS and FM. Intra-rater reliability, concurrent validity, minimum cut-off value, and patient responses were evaluated...
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29455899/perception-of-induced-dyspnea-in-fibromyalgia-and-chronic-fatigue-syndrome
#3
Maaike Van Den Houte, Katleen Bogaerts, Ilse Van Diest, Jozef De Bie, Philippe Persoons, Lukas Van Oudenhove, Omer Van den Bergh
OBJECTIVE: Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity. METHODS: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of CO2 in the blood, and self-reported dyspnea), and a recovery phase (150s of room air)...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29455165/community-deliverable-exercise-and-anxiety-in-adults-with-arthritis-and-other-rheumatic-diseases-a-systematic-review-with-meta-analysis-of-randomised-controlled-trials
#4
George A Kelley, Kristi S Kelley, Leigh F Callahan
BACKGROUND/PURPOSE: Given conflicting findings, the purpose of this study was to use the meta-analytic approach to examine the effects of exercise (aerobic, strength training or both) on anxiety in adults with arthritis and other rheumatic diseases (AORD). METHODS: Randomised controlled exercise intervention trials ≥4weeks in adults ≥18 years of age with osteoarthritis, rheumatoid arthritis or fibromyalgia were included. Studies were located by searching eight electronic databases, cross-referencing and expert review...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29454976/defective-endogenous-pain-modulation-in-fibromyalgia-a-meta-analysis-of-temporal-summation-and-conditioned-pain-modulation-paradigms
#5
REVIEW
Anthony Terrence O'Brien, Alicia Deitos, Yolanda Triñanes Pego, Felipe Fregni, Maria Teresa Carrillo-de-la-Peña
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients to healthy controls. We computed Hedge's g, risk of bias, sensitivity analysis and meta-regression tests with 10000 Monte-Carlo permutations. Twenty-three studies (625 female/23 male FM patients and 591 female/81 male healthy controls) were included. The meta-analyses showed an effect size of 0...
February 15, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29451066/psychometric-properties-of-mdhaq-rapid3-in-patients-with-systemic-lupus-erythematosus
#6
N Annapureddy, D Giangreco, H Devilliers, J A Block, M Jolly
Background The Multidimensional Health Assessment Questionnaire (MDHAQ) is a patient-reported outcome (PRO) tool that includes the Routine Assessment of Patient Index Data 3 (RAPID3), an index that can be calculated at the point of care. The objective of this study was to perform psychometric analyses of MDHAQ/RAPID3 to study its measurement properties in systemic lupus erythematosus (SLE). Methods The MDHAQ was completed by 161 SLE patients in routine care, along with LupusPRO (a disease-specific PRO). The SLE disease-specific activity index (SELENA-SLEDAI) and damage (SDI) were assessed...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29450798/catastrophizing-acceptance-and-coping-as-mediators-between-pain-and-emotional-distress-and-disability-in-fibromyalgia
#7
María J Lami, M Pilar Martínez, Elena Miró, Ana I Sánchez, Manuel A Guzmán
Catastrophizing, acceptance, and coping have an important predictive value in chronic pain; however, it is not known which of these variables has the greatest contribution in fibromyalgia (FM). This study explored the mediating role of catastrophizing, acceptance, and coping in the relationship between pain and emotional distress/disability in a FM sample. Ninety-two FM patients and 51 healthy participants controls were evaluated on pain- and psychological-related variables. Catastrophizing, acceptance, behavioral coping, and emotional coping were significantly correlated with emotional distress and/or disability...
February 15, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29447382/randomized-controlled-trial-of-acupuncture-for-women-with-fibromyalgia-group-acupuncture-with-traditional-chinese-medicine-diagnosis-based-point-selection
#8
Scott D Mist, Kim Dupree Jones
Background: Group acupuncture is a growing and cost-effective method for delivering acupuncture in the United States and is the practice model in China. However, group acupuncture has not been tested in a research setting. Objective: To test the treatment effect of group acupuncture vs group education in persons with fibromyalgia. Design: Random allocation two-group study with repeated measures. Setting: Group clinic in an academic health center in Portland, Oregon...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29447372/small-fiber-polyneuropathy-is-prevalent-in-patients-experiencing-complex-chronic-pelvic-pain
#9
Annie Chen, Elise De, Charles Argoff
Objective: To demonstrate the prevalence of small fiber polyneuropathy (SFPN) in patients with refractory chronic pelvic pain (CPP). Design: Retrospective study of prospective database. Subjects: Participants were complex CPP patients recruited from subspecity referral clinics defined as those who were refractory to initial treatment and/or exhibited comorbid pain syndromes at initial presentation. Methods: Comprehensive treatment history for CPP was obtained, and participants referred as above; 3-mm punch biopsies were obtained of the lower extremity and sent to diagnostic reference labs to evaluate for SFPN...
February 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29447138/inflammation-in-the-pathophysiology-of-neuropathic-pain
#10
Claudia Sommer, Mathias Leinders, Nurcan Üçeyler
Peripheral nerve injuries and diseases often lead to pain persisting beyond the resolution of damage, indicating an active disease-promoting process, which may result in chronic pain. This is regarded as a maladaptive mechanism resulting from neuroinflammation that originally serves to promote regeneration and healing. Knowledge on these physiological and pathophysiological processes has accumulated over the last few decades and has started to yield potential therapeutic targets. Key players are macrophages, T-lymphocytes, cytokines, and chemokines...
March 2018: Pain
https://www.readbyqxmd.com/read/29444083/high-fat-diet-sensitizes-fibromyalgia-like-pain-behaviors-in-mice-via-tumor-necrosis-factor-alpha
#11
Dan Tian, Miao Tian, Leilei Zhang, Peng Zhao, Yunfeng Cui, Jinlong Li
Fibromyalgia (FM) and obesity are closely related. However, little is known about how obesity contributes to FM. Importantly, adequate evidence has shown that tumor necrosis factor alpha (TNF-α) plays a critical role in obesity. Thus, we hypothesized that obesity-induced TNF-α release may potentiate FM-associated pain. To test this hypothesis, we investigated the role of TNF-α in the development of FM-like pain in a mouse model of acid saline injection-induced FM. Consistent with previous reports, we showed that repeated acid saline injections induced bilateral mechanical hyperalgesia, and this effect lasted for at least 4 days after acid saline injections...
2018: PloS One
https://www.readbyqxmd.com/read/29439873/prevalence-and-factors-associated-with-fatigue-in-female-patients-with-systemic-lupus-erythematosus
#12
Irene Carrión-Barberà, Tarek Carlos Salman-Monte, Sonia Castell, Francisco Castro, Fabiola Ojeda, Jordi Carbonell
OBJECTIVE: To determine the prevalence of fatigue in our cohort as well as the factors to which it is associated, its relationship with demographic variables, vitamin D levels, treatment, systemic lupus erythematosus (SLE) symptoms and disease activity. METHODS: A cross-sectional study was carried out including 102 consecutive female patients with SLE (American College of Rheumatology 1997 criteria) who attended the Parc de Salut Mar between January 2012 and May 2014...
February 10, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29439291/neurobiological-features-of-fibromyalgia-are-also-present-among-rheumatoid-arthritis-patients
#13
Neil Basu, Chelsea M Kaplan, Eric Ichesco, Tony Larkin, Richard E Harris, Alison Murray, Gordon Waiter, Daniel J Clauw
OBJECTIVES: Many rheumatoid arthritis (RA) patients report pain despite excellent control of inflammation with immunotherapies. Variable degrees of co-existing fibromyalgia (FM) may explain this disparity. FM has been characterised by aberrant brain functional connectivity, especially between the Default Mode Network (DMN) and insula. We hypothesised that RA patients reporting the highest 2011 ACR FM survey criteria scores- a continuous measure of FM degree also known as fibromyalgianess (FMness)- would demonstrate functional connectivity abnormalities similar to FM...
February 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29435567/benefits-and-harms-of-cranial-electrical-stimulation-for-chronic-painful-conditions-depression-anxiety-and-insomnia-a-systematic-review
#14
Paul G Shekelle, Ian A Cook, Isomi M Miake-Lye, Marika Suttorp Booth, Jessica M Beroes, Selene Mak
Background: Cranial electrical stimulation (CES) is increasingly popular as a treatment, yet its clinical benefit is unclear. Purpose: To review evidence about the benefits and harms of CES for adult patients with chronic painful conditions, depression, anxiety, and insomnia. Data Sources: Several databases from inception to 10 October 2017 without language restrictions and references from experts, prior reviews, and manufacturers. Study Selection: Randomized controlled trials of CES versus usual care or sham CES that reported pain, depression, anxiety, or sleep outcomes in any language...
February 13, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29430562/specific-symptoms-may-discriminate-between-fibromyalgia-patients-with-vs-without-objective-test-evidence-of-small-fiber-polyneuropathy
#15
Mette Lodahl, Roi Treister, Anne Louise Oaklander
Introduction: Multiple studies now confirm that ∼40% of patients with fibromyalgia syndrome meet diagnostic criteria for small-fiber polyneuropathy (SFPN) and have objective pathologic or physiologic evidence of SFPN, whereas 60% do not. Given possibilities that tens or hundreds of millions globally could have SFPN, developing screening tools becomes important. Objectives: This analysis explored whether specific symptoms might help distinguish these fibromyalgia endophenotypes...
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29428829/a-sensitive-and-selective-elisa-methodology-quantifies-a-demyelination-marker-in-experimental-and-clinical-samples
#16
Albert G Remacle, Jennifer Dolkas, Mila Angert, Swathi K Hullugundi, Andrei V Chernov, R Carter W Jones, Veronica I Shubayev, Alex Y Strongin
Sciatic nerve chronic constriction injury (CCI) in rodents produces nerve demyelination via proteolysis of myelin basic protein (MBP), the major component of myelin sheath. Proteolysis releases the cryptic MBP epitope, a demyelination marker, which is hidden in the native MBP fold. It has never been established if the proteolytic release of this cryptic MBP autoantigen stimulates the post-injury increase in the respective circulating autoantibodies. To measure these autoantibodies, we developed the ELISA that employed the cryptic 84-104 MBP sequence (MBP84-104) as bait...
February 8, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29428291/a-systematic-review-of-precipitating-physical-and-psychological-traumatic-events-in-the-development-of-fibromyalgia
#17
Yarden Yavne, Daniela Amital, Abdulla Watad, Shmuel Tiosano, Howard Amital
The role of physical and psychological trauma precipitating fibromyalgia is often encountered by physicians, yet a proper systematical review of this association is lacking. Literature searches identified 51 studies which examined the association of fibromyalgia with a preceding traumatic event of physical or emotional nature. The overall quality of evidence of studies included, as assessed by the GRADE criteria, was low, however the majority of studies described a significant association between prior physically traumatic events and the onset of chronic widespread pain or fibromyalgia...
January 10, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29426783/reduced-frontal-activity-during-a-verbal-fluency-test-in-fibromyalgia-a-near-infrared-spectroscopy-study
#18
Po-Han Chou, Kuo-Tung Tang, Yi-Hsing Chen, Chia-Wei Sun, Chih-Mao Huang, Der-Yuan Chen
Fibromyalgia (FM) is a complex disorder characterized by widespread chronic pain and associated sleep problems and cognitive dysfunction. However, only few studies focusing on cognitive dysfunction in FM are available so far. In the present study, we aimed to use near infrared spectroscopy (NIRS) to evaluate the brain function in FM patients subjected to a verbal fluency test (VFT). A total of 11 primary FM patients and 13 healthy individuals (HC) underwent NIRS while performing a VFT. The Fibromyalgia Impact Questionnaire (FIQ) was used to evaluate the symptom severity of FM and Beck Depression Inventory II (BDI) was used to evaluate the severities depression symptoms in study participants...
February 6, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29423878/ginger-rhizome-enhances-the-anti-inflammatory-and-anti-nociceptive-effects-of-paracetamol-in-an-experimental-mouse-model-of-fibromyalgia
#19
Sergio Montserrat-de la Paz, Maria Dolores Garcia-Gimenez, Ana Maria Quilez, Rocio De la Puerta, Angeles Fernandez-Arche
BACKGROUND: The dried rhizome of ginger has been widely used for more than 2500 years in folk medicine for the treatment of various diseases that involve inflammation or are caused by oxidative stress. AIMS: This study was designed to compare the anti-nociceptive and anti-inflammatory effect of dried powdered ginger rhizome (GR) and paracetamol (APAP) on an experimental mouse model of fibromyalgia syndrome (FMS) induced by intermittent cold stress (ICS). METHODS: Forty-eight female C57BL/6 J mice were used for the experiments...
February 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29421939/social-support-for-female-sexual-dysfunction-in-fibromyalgia
#20
José Granero-Molina, Tamara María Matarín Jiménez, Carmen Ramos Rodríguez, José Manuel Hernández-Padilla, Adelaida María Castro-Sánchez, Cayetano Fernández-Sola
The aim of this study is to describe and understand experiences related to social support for women with fibromyalgia who suffer from sexual dysfunction. An interpretive qualitative research methodology based on Gadamer's philosophical hermeneutics was used. Data collection included a focus group and in-depth interviews with 13 women who averaged 44.8 years of age and 14.3 years since being diagnosed with fibromyalgia. Data were analyzed using Fleming's method and two themes were identified: "searching for understanding in socio-family support" and "lack of formal support regarding fibromyalgia patient's sexuality...
March 2018: Clinical Nursing Research
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