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alopecia areata

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https://www.readbyqxmd.com/read/28094416/-seasonal-leukotrichia-in-a-german-shepherd-dog-a-case-report
#1
Janine Classen, Sonya V Bettenay, Ralf S Mueller
Leukotrichia can be caused by a variety of metabolic and inflammatory diseases. Canine alopecia areata is a rare multifactorial benign non-scarring alopecia. This case report describes a seasonally recurrent leukotrichia associated with alopecia areata in a German shepherd dog. Important differential diagnoses were ruled out and histopathology finally confirmed the diagnosis of alopecia areata. Topical tacrolimus and hydrocortisone aceponate were ineffective. The cause for the seasonal character in this case remained undetermined...
January 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28088907/tofacitinib-an-oral-janus-kinase-inhibitor-perspectives-in-dermatology
#2
Kresimir Kostovic, Sandra Jerkovic Gulin, Zrinka Bukvic Mokos, Romana Ceovic
BACKGROUND: Tofacitinib (formerly known as CP-690,550, CP690550, tasocitinib), a novel selective immunosuppressant, is a small molecule classified as Janus kinase inhibitor. The aim of this review article is to present updated data summary on the tofacitinib in the field of dermatology. METHOD: We undertook a structured search of bibliographic databases for peer-reviewed scientific articles, including review articles, original research articles as well as case report articles based on inclusion/exclusion criteria...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28074525/efficacy-of-superficial-cryotherapy-on-the-eyebrows-of-patients-with-alopecia-universalis-also-treated-with-contact-immunotherapy-on-the-scalp-a-prospective-split-face-comparative-study
#3
Sung Jay Choe, Won-Soo Lee
BACKGROUND: Few treatment modalities are available for treating alopecia areata (AA) of the eyebrow. Due to the anatomical proximity of the eyebrows to the eyes, safety issues and side effects should always be taken into consideration when choosing the treatment modality. This study was designed to examine the efficacy of superficial cryotherapy on patients with AA of the eyebrow. METHODS: Superficial cryotherapy was performed every other week on the right eyebrow (SC-treated) in a total of 20 patients who had been previously treated with diphenylcyclopropenone (DPCP) immunotherapy on the scalp...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28074524/trichoscopic-clues-for-diagnosis-of-alopecia-areata-and-trichotillomania-in-asians
#4
Saranya Khunkhet, Vasanop Vachiramon, Poonkiat Suchonwanit
BACKGROUND: Trichoscopy has become a useful diagnostic tool for various hair and scalp diseases, including alopecia areata (AA) and trichotillomania (TTM), which are sometimes difficult to distinguish clinically. OBJECTIVES: To describe trichoscopic findings of AA and TTM in an Asian population and to establish diagnostic clues for these conditions. METHODS: Trichoscopy was performed with a handheld dermoscope in 52 patients diagnosed with AA and 23 patients diagnosed with TTM...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28061966/new-treatments-for-hair-loss
#5
S Vañó-Galván, F Camacho
The treatment of hair loss is an important part of clinical dermatology given the prevalence of the problem and great impact on patients' quality of life. Many new treatments have been introduced in recent years. This review summarizes the main ones in 4 groups: a) For androgenetic alopecia, we discuss new excipients for oral minoxidil, dutasteride, and finasteride as well as new forms of topical application; prostaglandin agonists and antagonists; low-level laser therapy; and regenerative medicine with Wnt signaling activators and stem cell therapy...
January 3, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28055072/diversity-in-dermatology-clinical-trials-a-systematic-review
#6
Alexandra Charrow, Fan Di Xia, Cara Joyce, Arash Mostaghimi
Importance: Though there have been significant shifts in US demographic data over the past 50 years, research cohorts lack full racial and ethnic representation. There is little data available regarding the diversity of dermatology research cohorts with respect to sex, race, and ethnicity. Objective: To characterize and assess the representation of racial and ethnic minorities and women in randomized controlled trials across a range of dermatologic conditions. Evidence Review: All randomized clinical trials (RCTs) were identified between July 2010 and July 2015 within the PubMed database using the following keywords: "psoriasis," "atopic dermatitis," "acne," "vitiligo," "seborrheic dermatitis," "alopecia areata," and "lichen planus...
January 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28044367/bilateral-half-head-comparison-of-1-anthralin-ointment-in-children-with-alopecia-areata
#7
Mustafa Özdemir, Ali Balevi
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. METHODS: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment...
January 3, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28029683/alopecia-areata-incognita-in-cronkhite-canada-syndrome
#8
S Ong, C Rodriguez-Garcia, S Grabczynska, J Carton, M Osborn, J Walters, F Kubba, C M Stefanato
Cronkhite-Canada syndrome is an acquired inflammatory polyposis syndrome in which alopecia, onychomadesis and hyperpigmentation occur concurrently with gastrointestinal symptoms. The pathophysiology of alopecia in Cronkhite-Canada Syndrome has not been definitively elucidated and we present evidence for alopecia incognita as a possible mechanism of hair loss. This article is protected by copyright. All rights reserved.
December 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/28024126/janus-kinase-jak-inhibitors-for-the-treatment-of-skin-and-hair-disorders-a-review-of-literature
#9
Aniseh Samadi, Saman Ahmad Nasrollahi, Ashkan Hashemi, Mansour Nassiri-Kashani, Alireza Firooz
Janus kinase family (JAKs) has recently attracted the attention of many researchers, and several JAK inhibitor drugs have been developed targeting different members of the JAK family. Tofacitinib and ruxolitinib are U.S. FDA approved drugs in this family approved for rheumatoid arthritis and myeloproliferative diseases, respectively. Dysregulation of JAK/STAT pathway is also involved in many skin diseases, specifically inflammatory disorders. We overview the JAK/STAT signaling pathway and its involvement in skin diseases...
December 26, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27990839/alopecia-areata-as-a-paraneoplastic-syndrome-of-gastric-cancer
#10
Judith Álvarez Otero, Francisco Fernández Fernández, Javier de la Fuente Aguado
Alopecia areata produces hair loss in circular patches by an immune mechanism. The association with hematologic malignancies and with digestive tumors has been described. We report the case of a man who presented alopecia areata and two months later he was diagnosed with gastric adenocarcinoma.
December 19, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27986136/increased-blood-levels-of-nkg2d-cd4-t%C3%A2-cells-in-patients-with-alopecia-areata
#11
Yong Hyun Jang, Jin Kyeong Choi, Yun Hwan Jang, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Young-Ae Choi, Sang-Hyun Kim, Do Won Kim
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27968929/nutrition-and-skin-kids-are-not-just-little-people
#12
Meagen McCusker, Robert Sidbury
There has been a surge of new data regarding the pathophysiology of skin diseases. We are appreciating the sophisticated interplay among the skin, the immune system, and the environment. More elegant and highly specific medicines have been designed to target certain immune mediators of the adaptive immune system. In parallel fashion, we are learning more about the elegance of the innate immune system and how nutrition as early as the prenatal period can affect the priming of other immune cells. Concerns about the long-term impact of new immune-modulating medicines-especially in the pediatric population-have patients asking their dermatologists for nutritional alternatives to medical therapies...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27943234/immune-related-alopecia-areata-and-universalis-type-in-cancer-patients-receiving-immune-checkpoint-inhibitors
#13
A Zarbo, V R Belum, V Sibaud, S Oudard, M A Postow, J J Hsieh, R J Motzer, K J Busam, M E Lacouture
CTLA-4, PD-1, and PD-L1 monoclonal antibodies, commonly known as immune checkpoint inhibitors, are used for the treatment of various malignancies. The mechanism of action involves the inhibition of negative regulators of immune activation, which results in many patients developing immune-related adverse events (irAEs) including endocrinopathies, pneumonitis, colitis, hepatitis and dermatologic events. Dermatologic irAEs include maculopapular rash, pruritus, vitiligo, blistering disorders, mucocutaneous lichenoid eruptions, rosacea, and exacerbation of psoriasis...
December 11, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27904180/evaluation-of-clinical-significance-of-dermoscopy-in-alopecia-areata
#14
Akhila Sai Guttikonda, Chintaginjala Aruna, D V S B Ramamurthy, K Sridevi, Senthil Kumar L Alagappan
BACKGROUND: Alopecia areata (AA) is a common, chronic inflammatory disease characterized by nonscarring hair loss on the scalp or any hair-bearing area of the body. Recently, dermoscopy, a noninvasive diagnostic procedure, has been employed for the diagnosis of AA. AIM: To evaluate various dermoscopic patterns in AA and correlate these patterns with the disease activity and severity. MATERIALS AND METHODS: Dermoscopy was performed on AA patients using DL1 dermoscope (magnification ×10 was used)...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27886980/alopecia-areata-in-an-adolescent-with-inflammatory-bowel-disease
#15
Senthilkumar Sankararaman, Margaret Bobonich, Atiye Nur Aktay
No abstract text is available yet for this article.
November 24, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27882671/patient-perspectives-what-is-alopecia-areata
#16
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27881935/hair-diseases-a-big-problem-on-a-small-surface
#17
REVIEW
Ligia A Brzezińska-Wcisło, Dominika Wcisło-Dziadecka
Civilizational progress initially contributes to the problem of hair loss and then to alopecia as regards both frequency and therapeutic dilemmas. The work presents trichological problems which occur more rarely, i.e. drug-induced, anagen and telogen alopecia, congenital and acquired structural hair disorders, psychic disturbances concerning the hair as well as the hair during menopause. Then, the article briefly describes contagious (infectious) diseases as well as diseases with inflammatory etiology which are accompanied by exfoliation and (frequently) pruritus...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27871352/what-is-new-in-the-management-of-alopecia-areata
#18
Aditya K Gupta, Jessie Carviel, William Abramovits
No abstract text is available yet for this article.
2016: Skinmed
https://www.readbyqxmd.com/read/27871349/alopecia-areata-part-iii-prognosis-and-treatment
#19
Juliany Estefan, Marcia Ribeiro, Eliane Abad, Simone Saintive, Marcia Ramos-E-Silva
The prognosis of alopecia areata is better in cases with single and small lesions, and the variability of the extension of the disease is one of the criteria for the choice of treatment modality. Several medications have been described in the literature for the treatment of alopecia areata, including corticosteroids, minoxidil, and diphencyprone. The authors review treatments for alopecia areata.
2016: Skinmed
https://www.readbyqxmd.com/read/27861183/dermal-titanium-dioxide-deposition-associated-with-intralesional-triamcinolone-injection
#20
Brandon E Cohen, Sameer Bashey, Christine Cole, Jerrold L Abraham, Bruce Ragsdale, Binh Ngo
Cutaneous discoloration secondary to dermal deposition of titanium dioxide (TiO2) particles is recognized but seldom reported in the literature. In this report, the authors describe the case of a 61-year-old gentleman, with a long history of alopecia areata, who presented with numerous, discrete dark blue macules on the scalp. Scanning electron microscopy with energy dispersive x-ray spectroscopy analysis ultimately identified the macules as deposits of TiO2. The patient had a history of intralesional triamcinolone injections for management of alopecia areata...
December 2016: American Journal of Dermatopathology
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