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alopecia areata

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https://www.readbyqxmd.com/read/28748378/validation-of-an-egyptian-arabic-version-of-skindex-16-and-quality-of-life-measurement-in-egyptian-patients-with-skin-disease
#1
Nagwa Essa, Sara Awad, Mariam Nashaat
PURPOSE: To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease. METHOD: Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity...
July 26, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28747284/comorbid-autoimmune-diseases-in-patients-with-pemphigus-a-nationwide-case-control-study-in-taiwan
#2
Yun-Wen Chiu, Yen-Da Chen, Tuan-Chun Hua, Chi-Hung Wu, Han-Nan Liu, Yun-Ting Chang
Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. The odds of comorbidities between these two groups were analysed by multivariate logistic regression. Compared with control subjects, patients with pemphigus were much more likely to have Sjögren's syndrome (odds ratio [OR]: 15...
July 27, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28722460/-psychological-consequences-of-hair-loss
#3
Zora Dubská
Hair plays an important role in human life. Quantitative or qualitative changes of hair are therefore perceived unfavorably. The psychological consequences of hair loss are described in both androgenic alopecia and alopecia areata. Alopecia areata should be distinguished from other diagnostic units such as trichotillomania. The issue of hair disease requires a multidisciplinary collaboration, in which the dermatologist has a key role to play.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28717940/alopecia-areata-a-comprehensive-review-of-pathogenesis-and-management
#4
REVIEW
Ralph M Trüeb, Maria Fernanda Reis Gavazzoni Dias
Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. The current understanding is that the condition represents an organ-specific autoimmune disease of the hair follicle with a genetic background. Genome-wide association studies provide evidence for the involvement of both innate and acquired immunity in the pathogenesis, and mechanistic studies in mouse models of alopecia areata have specifically implicated an IFN-γ-driven immune response, including IFNγ, IFNγ-induced chemokines and cytotoxic CD8 T cells as the main drivers of disease pathogenesis...
July 17, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28714061/establishing-and-prioritising-research-questions-for-the-prevention-diagnosis-and-treatment-of-hair-loss-excluding-alopecia-areata-the-hair-loss-priority-setting-partnership
#5
A Macbeth, J Tomlinson, A Messenger, K Moore-Millar, C Michaelides, A Shipman, J Kassim, J Brockley, W Szczecinska, P Farrant, R Robinson, J Rodgers, J Chambers, S Upadhyaya, M Harries
BACKGROUND: Hair and scalp problems are common. Unfortunately, many uncertainties exist around the most effective management and treatments strategies for these disorders. OBJECTIVES: To identify uncertainties in hair loss management, prevention, diagnosis and treatment that are important to both people with hair loss and healthcare professionals. METHODS: A hair loss priority setting partnership was established between patients, their carers and relatives, and healthcare professionals to identify the most important uncertainties in hair loss...
July 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#6
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28701183/ruxolitinib-found-to-cause-eyelash-growth-a-case-report
#7
Julia Song, Alice Song, Trisa Palmares, Michael Song, Harold Song
BACKGROUND: Hypereosinophilic syndrome is a hematologic disorder in which the eosinophils proliferate. Oral Janus kinase inhibitors are known to be effective treating hypereosinophilic syndrome. Janus kinase inhibitors have also demonstrated efficacy in alopecia. Madarosis is a condition in which the eyelashes are missing or absent and can been seen in alopecia patients. CASE PRESENTATION: We present the case of a 77-year-old Asian man who was diagnosed with hypereosinophilic syndrome, refractive to all medications except ruxolitinib...
July 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28698747/association-among-thyroid-dysfunction-asthma-allergic-rhinitis-and-eczema-in-children-with-alopecia-areata
#8
Javad Ghaffari, Ghasem Rahmatpour Rokni, Armaghan Kazeminejad, Hosein Abedi
BACKGROUND: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition. AIM: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. METHODS: This case-control study was conducted on 50 patients with alopecia areata, diagnosed by a dermatologist, and 150 healthy individuals as the control group...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28685843/oxidative-stress-management-in-the-hair-follicle-could-targeting-nrf2-counter-age-related-hair-disorders-and-beyond
#9
REVIEW
Laura Jadkauskaite, Pierre A Coulombe, Matthias Schäfer, Albena T Dinkova-Kostova, Ralf Paus, Iain S Haslam
Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition...
August 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28670255/25-hydroxyvitamin-d-status-in-patients-with-alopecia-areata
#10
Seval Erpolat, Evren Sarifakioglu, Abdullah Ayyildiz
INTRODUCTION: Alopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-phase hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases. AIM: To investigate the status of serum 25-hydroxyvitamin D (25(OH)D) in patients with AA, serum 25(OH)D concentrations were compared between AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH)D levels and AA...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28646393/the-changing-landscape-of-alopecia-areata-the-therapeutic-paradigm
#11
REVIEW
Yael Renert-Yuval, Emma Guttman-Yassky
Alopecia areata (AA), a prevalent inflammatory cause of hair loss, lacks FDA-approved therapeutics for extensive cases, which are associated with very poor rates of spontaneous hair regrowth and major psychological distress. Current treatments for severe cases include broad immune-suppressants, which are associated with significant adverse effects, precluding long-term use, with rapid hair loss following treatment termination. As a result of the extent of the disease in severe cases, topical contact sensitizers and intralesional treatments are of limited use...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28646392/the-changing-landscape-of-alopecia-areata-the-translational-landscape
#12
REVIEW
Etienne C E Wang, Angela M Christiano
Recent genetic and preclinical studies have increased our understanding of the immunopathogenesis of alopecia areata (AA). This has allowed expedited development of targeted therapies for the treatment of AA, and a paradigm shift in our approach and understanding of autoimmunity and the hair follicle. The synergy between preclinical studies, animal models, and translational studies has led to unprecedented advances in the treatment options for AA, ultimately benefiting patients who have had little recourse...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28646391/the-changing-landscape-of-alopecia-areata-an-introduction
#13
REVIEW
George Han
Alopecia areata is an extremely common autoimmune condition affecting hair. Severe forms of alopecia areata exist, with existing treatments consisting of systemic immunosuppressants with numerous side effects. Recently, breakthroughs have been made in both understanding the pathogenesis of alopecia areata and the treatment thereof, which hold the promise of being able to target severe cases of alopecia areata with more efficacy and better tolerability. This article serves as an introduction to review papers from two of the leading researchers in the field of alopecia areata...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28641742/the-good-and-bad-news-about-new-drugs-for-treating-alopecia-areata
#14
D Morgado-Carrasco, E Rodríguez-Lobato, J Riera-Monroig, J Ferrando
No abstract text is available yet for this article.
June 19, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28638587/association-between-helicobacter-pylori-infection-and-alopecia-areata-a-study-in-iranian-population
#15
Elham Behrangi, Parvin Mansouri, Shahram Agah, Nasser Ebrahimi Daryani, Marjan Mokhtare, Zahra Azizi, Mona Ramezani Ghamsari, Masoumeh Rohani Nasab, Zahra Azizian
BACKGROUND Alopecia areata is an immune mediated inflammatory hair loss, which occurs in all ethnic and age groups, and both sexes. However no significant etiology has been known for this disease. Helicobacter pylori (H. pylori) , is an organism colonized in gastric mucosa. This bacterium has been associated with certain extra-digestive dermatological conditions. The causal relationship between alopecia areata and H. pylori infection has been discussed in literature. Therefore, we conducted this study to evaluate the prevalence of H...
April 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28635319/a-case-of-topical-ruxolitinib-treatment-failure-in-alopecia-areata
#16
Maya Deeb, Renée A Beach
Alopecia areata (AA) is an autoimmune-mediated, nonscarring form of hair loss. Despite its prevalence, current management options are limited, especially when the disease has progressed to alopecia totalis (AT) or alopecia universalis (AU). Recent evidence that janus kinase (JAK) signaling contributes to AA pathogenesis prompted the investigation of JAK inhibitors such as tofacitinib and ruxolitinib as possible oral treatments. However, the potential for significant adverse effects with systemic JAK inhibition makes local administration a more attractive option...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28635045/management-of-alopecia-areata-updates-and-algorithmic-approach
#17
REVIEW
Solam Lee, Won-Soo Lee
Alopecia areata is a chronic, recurrent and non-scarring alopecia. The prognoses of patients are very diverse. The larger the area of hair loss, the poorer the treatment response and greater the probability of chronic disease progression. Numerous treatments have been introduced, but curative treatments have yet to be established. The long-term efficacy of the current treatments is minimal, and the therapeutic response varies widely. Recent clinical trials have attempted to apply therapeutic metrics, such as the Severity of Alopecia Tool, and many have been designed as randomized controlled studies, enabling a more precise evaluation of existing treatments...
June 21, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28632888/excellent-response-to-tofacitinib-treatment-in-a-patient-with-alopecia-universalis
#18
Funda Erduran, Esra Adışen, Ahmet Burhan Aksakal
Alopecia universalis (AU) is generally considered a variant of alopecia areata (AA), in which the treatment options seldom provide satisfactory results. However, successful treatment of several cases of AA and its variants with oral Janus kinase (JAK) inhibitors have been reported recently. Here we report a 23-year-old female patient with AU successfully treated with tofacitinib, a selective JAK-3 inhibitor. The initial tofacitinib dose was 5 mg twice daily. After 2 months of treatment, partial hair regrowth was seen on the scalp and eyebrows...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28627278/methotrexate-for-the-treatment-of-pediatric-alopecia-areata
#19
Erin T Landis, Rita O Pichardo-Geisinger
PURPOSE: Alopecia areata is a form of nonscarring hair loss that occurs in pediatric and adult patients, with presentation varying from round or ovoid patches of alopecia to alopecia totalis or universalis. While frustrating for patients, it can also be frustrating for clinicians to treat, as there is no definitive treatment. Dermatologists are very familiar with the use of methotrexate for psoriasis and other inflammatory skin diseases, and this medication is generally well tolerated in children...
June 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28619558/systematic-review-and-quality-analysis-of-studies-on-the-efficacy-of-topical-diphenylcyclopropenone-treatment-for-alopecia-areata
#20
Yong Hyun Jang, Han Jin Jung, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Won Kee Lee, Do Won Kim
No abstract text is available yet for this article.
July 2017: Journal of the American Academy of Dermatology
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