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https://www.readbyqxmd.com/read/27663941/randomized-controlled-trial-of-intravenous-immunoglobulin-for-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#1
Kyle A Williams, Susan E Swedo, Cristan A Farmer, Heidi Grantz, Paul J Grant, Precilla D'Souza, Rebecca Hommer, Liliya Katsovich, Robert A King, James F Leckman
OBJECTIVE: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are hypothesized to occur as a result of cross-reactive antibodies produced in response to group A streptococcal infections. Previous research suggests that immunomodulatory therapies, such as intravenous immunoglobulin (IVIG), may lead to rapid and sustained symptom improvement in patients with PANDAS. METHOD: A total of 35 children meeting criteria for PANDAS and moderate to severe obsessive-compulsive disorder (OCD) were enrolled in a randomized-entry, double-blind, placebo-controlled, 6-week trial of IVIG (1 g/kg/day on 2 consecutive days), followed by optional open-label treatment for nonresponders, with follow-up at 12 and 24 weeks...
October 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27166296/rapid-eye-movement-sleep-abnormalities-in-children-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans
#2
Thomas Gaughan, Ashura Buckley, Rebecca Hommer, Paul Grant, Kyle Williams, James F Leckman, Susan E Swedo
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep...
July 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/24184556/brain-human-monoclonal-autoantibody-from-sydenham-chorea-targets-dopaminergic-neurons-in-transgenic-mice-and-signals-dopamine-d2-receptor-implications-in-human-disease
#3
Carol J Cox, Meenakshi Sharma, James F Leckman, Jonathan Zuccolo, Amir Zuccolo, Abraham Kovoor, Susan E Swedo, Madeleine W Cunningham
How autoantibodies target the brain and lead to disease in disorders such as Sydenham chorea (SC) is not known. SC is characterized by autoantibodies against the brain and is the main neurologic manifestation of streptococcal-induced rheumatic fever. Previously, our novel SC-derived mAb 24.3.1 was found to recognize streptococcal and brain Ags. To investigate in vivo targets of human mAb 24.3.1, VH/VL genes were expressed in B cells of transgenic (Tg) mice as functional chimeric human VH 24.3.1-mouse C-region IgG1(a) autoantibody...
December 1, 2013: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/22534626/behavioral-pharmacological-and-immunological-abnormalities-after-streptococcal-exposure-a-novel-rat-model-of-sydenham-chorea-and-related-neuropsychiatric-disorders
#4
Lior Brimberg, Itai Benhar, Adita Mascaro-Blanco, Kathy Alvarez, Dafna Lotan, Christine Winter, Julia Klein, Allon E Moses, Finn E Somnier, James F Leckman, Susan E Swedo, Madeleine W Cunningham, Daphna Joel
Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham chorea (SC). Our aim was to develop an animal model that resembled the behavioral, pharmacological, and immunological abnormalities of SC and other streptococcal-related neuropsychiatric disorders. Male Lewis rats exposed to GAS antigen exhibited motor symptoms (impaired food manipulation and beam walking) and compulsive behavior (increased induced-grooming)...
August 2012: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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